1. Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab.
- Author
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ZINK, Alexander, GENSBAUR, Anna, ZIRBS, Michael, SEIFERT, Florian, SUAREZ, Isabel LEON, MOURANTCHANIAN, Vagkan, WEIDINGER, Stephan, MEMPEL, Martin, RING, Johannes, and OLLERT, Markus
- Subjects
IMMUNOGLOBULIN E ,ATOPIC dermatitis ,IMMUNOADSORPTION ,SERUM ,SYMPTOMS - Abstract
Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE levels decreased after immunoadsorption and decreased continuously in all patients during anti- IgE therapy. The reverse trend was observed during 6 months follow-up without treatment. In parallel with these observations, an improvement in AD was observed during the treatment period, with aggravation during follow-up. Further research is needed, based on the principle of reducing IgE levels in order to improve clinical symptoms, using a combination anti-IgE treatment approach, adjusted according to IgE levels. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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