1. Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single-center experience.
- Author
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Fujisawa Y, Nakamura Y, Kawachi Y, and Otsuka F
- Subjects
- Aged, Aged, 80 and over, Bridged-Ring Compounds, Case-Control Studies, Female, Hemangiosarcoma drug therapy, Hemangiosarcoma surgery, Humans, Interleukin-2 therapeutic use, Male, Middle Aged, Neoplasm Recurrence, Local drug therapy, Radiotherapy, Adjuvant, Retrospective Studies, Skin Neoplasms drug therapy, Skin Neoplasms surgery, Antineoplastic Agents therapeutic use, Hemangiosarcoma therapy, Skin Neoplasms therapy, Taxoids therapeutic use
- Abstract
Objective: To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma., Methods: A case-control study comparing patients who received taxanes without wide local excision (group A, n = 5) and patients who received conventional surgery-based therapy (group B, n = 8) in one university hospital in eastern Japan. Data were collected from a total of 13 patients with cutaneous angiosarcoma treated from November 1997 through July 2009., Results: Group A received taxanes: four patients received docetaxel, and one patient received paclitaxel. Radiation was used concomitantly in two patients. Marginal local excision was performed in two patients. Group B received wide local excision followed by radiation (six patients), docetaxel (three patients), and interleukin-2 (two patients). No patients in group A had local recurrence, whereas five out of the eight patients in group B did (p < 0.05, chi-square test). Median overall survival was 31 months in group A and 10 months in group B. Estimated overall survival using the Kaplan-Meier method was significantly longer in group A (p < 0.05, log-rank test)., Conclusion: In our series, taxane-based chemotherapy was superior to conventional surgery-based therapy. Our results indicated that taxane regimens without mutilating surgery offered both local control and prevention of metastasis, which led to prolonged survival.
- Published
- 2014
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