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5 results on '"Trofimova ES"'

1. Effect of IKK-2 inhibitor on local Th1 and Th2 type inflammation.

Author

Ligacheva AA, Ivanova AN, Belsky YP, Belska NV, Trofimova ES, Danilets MG, and Dygai AM

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Edema drug therapy, Female, Hypersensitivity, Delayed immunology, Hypersensitivity, Immediate immunology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, NF-kappa B metabolism, Th1 Cells drug effects, Th2 Cells drug effects, Diclofenac pharmacology, Hypersensitivity, Delayed drug therapy, Hypersensitivity, Immediate drug therapy, I-kappa B Kinase antagonists & inhibitors, Phenylurea Compounds pharmacology, Th1 Cells immunology, Th2 Cells immunology, Thiophenes pharmacology
Abstract

We studied the capacity of IKK-2 inhibitor ([5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide) and non-steroidal anti-inflammatory drug voltaren to reduce the severity of local inflammation in Th1- and Th2-type immune response. The test substances (inhibitor in concentrations from 2×10(-13)to 2×10(-16)M and 9.8×10(-4)M voltaren) were shown to reduce edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response (Th2-type immune response). The anti-inflammatory effects of IKK-2 inhibitor in Th1-type immune response were similar to those of voltaren.

Published
2013
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2. Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response.

Author

Ligacheva AA, Ivanova AN, Belsky YP, Belska NV, Trofimova ES, Danilets MG, and Dygai AM

Subjects
Analysis of Variance, Animals, Cytokines immunology, Diclofenac pharmacology, Diclofenac therapeutic use, Erythrocytes, Female, Gold Sodium Thiomalate therapeutic use, Hypersensitivity, Delayed chemically induced, Hypersensitivity, Immediate chemically induced, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Ovalbumin toxicity, Gold Sodium Thiomalate pharmacology, Hypersensitivity, Delayed drug therapy, Hypersensitivity, Immediate drug therapy, Immunity, Cellular immunology, NF-kappa B antagonists & inhibitors, Th1 Cells immunology, Th2 Cells immunology
Abstract

We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.

Published
2012
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3. [Effect of plant polysaccharides on TH1-dependent immune response: screening investigation].

Author

Danilets MG, Bel'skiĭ IuP, Gur'ev AM, Belousov MV, Bel'skaia NV, Trofimova ES, Uchasova EG, Alhmedzhanov RR, Ligacheva AA, Iusbov MS, and Agefonov VI

Subjects
Animals, Cells, Cultured, Drug Evaluation, Preclinical, Erythrocytes immunology, Lipopolysaccharides pharmacology, Macrophages, Peritoneal enzymology, Mice, Mice, Inbred BALB C, Nitric Oxide biosynthesis, Nitric Oxide Synthase biosynthesis, Nitric Oxide Synthase immunology, Plant Extracts chemistry, Sheep, Th1 Cells metabolism, Macrophages, Peritoneal immunology, Nitric Oxide immunology, Plant Extracts pharmacology, Plants chemistry, Th1 Cells immunology
Abstract

We have studied the influence of water-soluble polysaccharides isolated from Tussilago farfara L. leaves, Betula verrucosa Ehrh. leaves, Calendula officinalis L. flowers, Acorus calamus rhizomes, Inula helenium L. rhizomes, overground part of Trifolium pretense L., and overground part ofArtemisia absinthium L., on Thl immune response induced by sheep red blood cells and on NO production by murine peritoneal macrophages in vitro. All the investigated polysaccharides have stimulated a Th1 response. Polysaccharides isolated from Betula verrucosa leaves did not influence NO synthesis, while polysaccharides of Tussilago farfara leaves and Acorus calamus rhizomes stimulated NO synthase of murine macrophages on a level comparable with that of lipopolysaccharides (LPS). Polysaccharides from Inula helenium rhizomes, Calendula officinalis flowers, and overground parts of Trifolium pretense and Artemisia absinthium also stimulated NO production, but to a lower extent in comparison to LPS.

Published
2010

4. [Antiallergic effect of D-glucuronic acid].

Author

Danilets MG, Bel'skiĭ IuP, Bel'skaia NF, Trofimova ES, Uchasova EG, Ligacheva AA, and Agafonov VI

Subjects
Anaphylaxis immunology, Animals, Antibody Formation immunology, Hypersensitivity, Delayed drug therapy, Hypersensitivity, Delayed immunology, Immunoglobulin E immunology, Immunoglobulin G immunology, Mice, Mice, Inbred BALB C, Rats, Anaphylaxis drug therapy, Anti-Allergic Agents pharmacology, Antibody Formation drug effects, Glucuronic Acid pharmacology, Th1 Cells immunology, Th2 Cells immunology
Abstract

The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.

Published
2008

5. Effects of natural suppressor cells on production of Th1 and Th2 cytokines and proliferation of polarized T cells.

Author

Bel'skaya NV, Bel'skii YP, Danilets MG, Trofimova ES, Sherstoboev EY, and Agafonov VI

Subjects
Animals, Bone Marrow Cells metabolism, Cell Proliferation, Hydrogen-Ion Concentration, Immunosuppressive Agents pharmacology, Interleukin-2 metabolism, Interleukin-4 metabolism, Lymphocytes metabolism, Mice, Mice, Inbred BALB C, Cytokines metabolism, Gene Expression Regulation, T-Lymphocytes, Regulatory metabolism, Th1 Cells metabolism, Th2 Cells metabolism
Abstract

Natural suppressor cells from the bone marrow of intact animals and mice with Th1- and Th2-dependent immune response largely suppressed the production of Th1 (IFN-gamma, IL-2) and Th2 cytokines (IL-4). Antiproliferative activity of natural suppressor cells from intact and immunized animals was mediated by NO. Proliferation of Th1 cells was suppressed greater than that of Th2 cells. This selective effect of natural suppressor cells on the proliferation of target lymphocytes was due to higher stimulatory potential of Th1 cells (in comparison with Th2) towards natural suppressor cells.

Published
2006
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