Search

Your search keyword '"Voltage-dependent potassium 7 channels"' showing total 2 results
Start Over Descriptor "Voltage-dependent potassium 7 channels" Topic therapeutics. pharmacology
2 results on '"Voltage-dependent potassium 7 channels"'

1. Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Author

Hirohito Esaki, Shoma Izumi, Akari Fukao, Naoya Nishitani, Satoshi Deyama, and Katsuyuki Kaneda

Subjects
Nicotine, Medial prefrontal cortex, Voltage-dependent potassium 7 channels, Therapeutics. Pharmacology, RM1-950
Abstract

Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memory. Moreover, this effect was inhibited by infusion of retigabine, a selective voltage-dependent potassium 7 (Kv7) channel opener, into the medial prefrontal cortex (mPFC) before nicotine administration. Additionally, infusion of XE-991, a selective Kv7 channel blocker, into the mPFC before training enhanced object recognition memory. Therefore, Kv7 channels in the mPFC may be at least partly involved in nicotine-induced enhancement of object recognition memory.

Published
2021
Full Text
View/download PDF

2. Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Author

Akari Fukao, Shoma Izumi, Naoya Nishitani, Katsuyuki Kaneda, Hirohito Esaki, and Satoshi Deyama

Subjects
Male, 0301 basic medicine, Nicotine, Kv7 channels, Potassium, Prefrontal Cortex, chemistry.chemical_element, RM1-950, Phenylenediamines, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Memory, medicine, Animals, Channel blocker, Novel object recognition, Prefrontal cortex, Anthracenes, Pharmacology, Voltage-dependent potassium 7 channels, Retigabine, Cognitive neuroscience of visual object recognition, Recognition, Psychology, Medial prefrontal cortex, Stimulation, Chemical, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Potassium Channels, Voltage-Gated, Molecular Medicine, Carbamates, Therapeutics. Pharmacology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug
Abstract

Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memory. Moreover, this effect was inhibited by infusion of retigabine, a selective voltage-dependent potassium 7 (Kv7) channel opener, into the medial prefrontal cortex (mPFC) before nicotine administration. Additionally, infusion of XE-991, a selective Kv7 channel blocker, into the mPFC before training enhanced object recognition memory. Therefore, Kv7 channels in the mPFC may be at least partly involved in nicotine-induced enhancement of object recognition memory.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results