35 results on '"Husain SA"'
Search Results
2. Radical Transparency to Improve Equity in the Kidney Allocation System.
- Author
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Husain SA, Adler JT, and Mohan S
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- Humans, Kidney, Health Services Accessibility, Tissue and Organ Procurement
- Published
- 2024
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- View/download PDF
3. UNOS Decisions Impact Data Integrity of the OPTN Data Registry.
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Tsapepas DS, King K, Husain SA, Yu ME, Hippen BE, Schold JD, and Mohan S
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- Aged, Humans, United States epidemiology, Reproducibility of Results, Medicare, Registries, Organ Transplantation adverse effects, Tissue and Organ Procurement, Peripheral Vascular Diseases
- Abstract
Background: The Organ Procurement Transplant Network (OPTN)/United Network for Organ Sharing (UNOS) registry is an important national registry in the field of solid organ transplantation. Data collected are mission critical, given its role in organ allocation prioritization, program performance monitoring by both the OPTN and the Centers for Medicare & Medicaid Services, and countless observational analyses that helped to move the field forward. Despite the multifaceted importance of the OPTN/UNOS database, there are clear indications that investments in the database to ensure the quality and reliability of the data have been lacking., Methods: This analysis outlines 2 examples: (1) primary diagnosis for patients who are receiving a second transplant and (2) reporting peripheral vascular disease in kidney transplantation to illustrate the extensive challenges facing the veracity and integrity of the OPTN/UNOS database today., Results: Despite guidance that repeat kidney transplant patients should be coded as "retransplant/graft failure" rather than their native kidney disease, only 59% of new incident patients are coded in this manner. Peripheral vascular disease prevalence more than doubled in a 20-y span when the variable became associated with risk adjustment., Conclusions: This article summarizes critical gaps in the OPTN/UNOS database, and we bring forward ideas and proposals for consideration as a path toward improvement., Competing Interests: The authors declare no funding or conflicts of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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4. Discrepant Outcomes between National Kidney Transplant Data Registries in the United States.
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Yu M, King KL, Husain SA, Huml AM, Patzer RE, Schold JD, and Mohan S
- Subjects
- Humans, United States epidemiology, Cross-Sectional Studies, Registries, Living Donors, Graft Survival, Tissue Donors, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
Significance Statement: Effects of reduced access to external data by transplant registries to improve accuracy and completeness of the collected data are compounded by different data management processes at three US organizations that maintain kidney transplant-related datasets. This analysis suggests that the datasets have large differences in reported outcomes that vary across different subsets of patients. These differences, along with recent disclosure of previously missing outcomes data, raise important questions about completeness of the outcome measures. Differences in recorded deaths seem to be increasing in recent years, reflecting the adverse effects of restricted access to external data sources. Although these registries are invaluable sources for the transplant community, discrepancies and incomplete reporting risk undermining their value for future analyses, particularly when used for developing national transplant policy or regulatory measures., Background: Central to a transplant registry's quality are accuracy and completeness of the clinical information being captured, especially for important outcomes, such as graft failure or death. Effects of more limited access to external sources of death data for transplant registries are compounded by different data management processes at the United Network for Organ Sharing (UNOS), the Scientific Registry of Transplant Recipients (SRTR), and the United States Renal Data System (USRDS)., Methods: This cross-sectional registry study examined differences in reported deaths among kidney transplant candidates and recipients of kidneys from deceased and living donors in 2000 through 2019 in three transplant datasets on the basis of data current as of 2020. We assessed annual death rates and survival estimates to visualize trends in reported deaths between sources., Results: The UNOS dataset included 77,605 deaths among 315,346 recipients and 61,249 deaths among 275,000 nonpreemptively waitlisted candidates who were never transplanted. The SRTR dataset included 87,149 deaths among 315,152 recipients and 60,042 deaths among 259,584 waitlisted candidates. The USRDS dataset included 89,515 deaths among 311,955 candidates and 63,577 deaths among 238,167 waitlisted candidates. Annual death rates among the prevalent transplant population show accumulating differences across datasets-2.31%, 4.00%, and 4.03% by 2019 from UNOS, SRTR, and USRDS, respectively. Long-term survival outcomes were similar among nonpreemptively waitlisted candidates but showed more than 10% discordance between USRDS and UNOS among transplanted patients., Conclusions: Large differences in reported patient outcomes across datasets seem to be increasing, raising questions about their completeness. Understanding the differences between these datasets is essential for accurate, reliable interpretation of analyses that use these data for policy development, regulatory oversight, and research., Podcast: This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2023_10_24_JASN0000000000000194.mp3., (Copyright © 2023 by the American Society of Nephrology.)
- Published
- 2023
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5. Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation.
- Author
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Cron DC, Husain SA, King KL, Mohan S, and Adler JT
- Subjects
- Humans, Tissue Donors, Kidney, Waiting Lists, Tissue and Organ Procurement, Kidney Transplantation, Transplants
- Abstract
The newest kidney allocation policy kidney allocation system 250 (KAS250) broadened geographic distribution while increasing allocation system complexity. We studied the volume of kidney offers received by transplant centers and the efficiency of kidney placement since KAS250. We identified deceased-donor kidney offers (N = 907,848; N = 36,226 donors) to 185 US transplant centers from January 1, 2019, to December 31, 2021 (policy implemented March 15, 2021). Each unique donor offered to a center was considered a single offer. We compared the monthly volume of offers received by centers and the number of centers offered before the first acceptance using an interrupted time series approach (pre-/post-KAS250). Post-KAS250, transplant centers received more kidney offers (level change: 32.5 offers/center/mo, P < .001; slope change: 3.9 offers/center/mo, P = .003). The median monthly offer volume post-/pre-KAS250 was 195 (interquartile range 137-253) vs. 115 (76-151). There was no significant increase in deceased-donor transplant volume at the center level after KAS250, and center-specific changes in offer volume did not correlate with changes in transplant volume (r = -0.001). Post-KAS250, the number of centers to whom a kidney was offered before acceptance increased significantly (level change: 1.7 centers/donor, P < .001; slope change: 0.1 centers/donor/mo, P = .014). These findings demonstrate the logistical burden of broader organ sharing, and future allocation policy changes will need to balance equity in transplant access with the operational efficiency of the allocation system., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Adler reports personal fees from Tegus and grants from AHRQ. Dr. Mohan reports personal fees for eGenesis and Kidney International Reports, grants from the NIH and Kidney Transplant Collaborative, serving as chair of the UNOS data advisory committee and as faculty cochair for the ESRD Treatment Choices Learning Collaborative outside of the submitted work. Dr. Husain reported receiving grants personal fees from Fresenius and grants from NIH outside of the submitted work., (Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
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6. Policy Strategies to Reduce Financial Risks for Living Donors.
- Author
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Husain SA and Lentine KL
- Subjects
- Humans, Living Donors, Policy, Kidney Transplantation, Tissue and Organ Procurement
- Published
- 2023
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7. Influence of organ quality on the observed association between deceased donor kidney procurement biopsy findings and graft survival.
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Husain SA, King KL, Cron DC, Lentine KL, Adler JT, and Mohan S
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- Humans, United States, Graft Survival, Retrospective Studies, Donor Selection, Creatinine, Tissue Donors, Kidney pathology, Biopsy, Tissue and Organ Procurement, Kidney Transplantation
- Abstract
Deceased donor kidney procurement biopsies findings are the most common reason for kidney discard. Retrospective studies have found inconsistent associations with post-transplant outcomes but may have been limited by selection bias because kidneys with advanced nephrosclerosis from high-risk donors are typically discarded. We conducted a retrospective cohort study of kidneys transplanted in the United States from 2015 to 2019 with complete biopsy data available, defining "suboptimal histology" as glomerulosclerosis ≥11%, IFTA ≥mild, and/or vascular disease ≥mild. We used time-to-event analyses to determine the association between suboptimal histology and death-censored graft failure after stratification by kidney donor profile index (KDPI) (≤35%, 36%-84%, ≥85%) and final creatinine (<1 mg/dl, 1-2 mg/dl, >2 mg/dl). Among 30 469 kidneys included, 36% had suboptimal histology. In adjusted analyses, suboptimal histology was associated with death-censored graft failure among kidneys with KDPI 36-84% (HR 1.22, 95% CI 1.09-1.36), but not KDPI≤35% (HR 1.24, 0.94-1.64) or ≥ 85% (HR 0.99, 0.81-1.22). Similarly, suboptimal histology was associated with death-censored graft failure among kidneys from donors with creatinine 1-2 mg/dl (HR 1.39, 95% CI 1.20-1.60) but not <1 mg/dl (HR 1.07, 0.93-1.23) or >2 mg/dl (HR 0.95, 0.75-1.20). The association of procurement histology with graft longevity among intermediate-quality kidneys that were likely to be both biopsied and transplanted suggests biopsies provide independent organ quality assessments., (© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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- 2022
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8. Kidney nonprocurement in deceased donors with acute kidney injury.
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Yu K, Husain SA, King K, Stevens JS, Parikh CR, and Mohan S
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- Humans, Tissue Donors, Kidney, Graft Survival, Donor Selection, Kidney Transplantation, Tissue and Organ Procurement, Acute Kidney Injury etiology
- Abstract
Background: Acute kidney injury (AKI) is common in deceased organ donors and is associated with high rates of kidney discard by transplant centers. High discard rates may consequently drive nonprocurement of these kidneys by organ procurement organizations. We aimed to study the relationship between donor AKI and kidney nonprocurement., Methods: Using U.S. registry data, we identified donors with at least one organ recovered from 2008 to 2018. We compared characteristics of donors with no kidneys procured across AKI stages, and used multivariable logistic regression to evaluate the relationship between AKI severity and kidney nonprocurement., Results: Overall 14 543 kidneys from 7620 donors were not procured, among which 93% were from donors with AKI. For 6945 donors with no kidneys procured but an extrarenal organ recovered, most had stage 3 (51%), followed by stage 1 (27%) and stage 2 AKI (15%). Nonprocured stage 3 donors were the youngest and had the lowest Kidney Donor Risk Index of all nonprocured donors. Adjusted odds of kidney nonprocurement were 1.14 (95%CI 1.02-1.27) for stage 1, 1.25 (95%CI 1.12-1.41) for stage 2, and 10.37 (95%CI 9.30-11.56) for stage 3 donors, compared to non-AKI donors. Among donors with minimum creatinine <1.5 mg/dl, stage 2 and 3 AKI were still associated with significantly higher odds of nonprocurement., Conclusions: AKI severity is a strong risk factor for kidney nonprocurement. Efforts to address the organ shortage should focus on encouraging procurement and utilization of kidneys from deceased donors with severe AKI, given the large and rising prevalence of donor AKI and excellent transplant outcomes with these kidneys., (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2022
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9. More is better … until it is worse: Can organ placement processes scale to an increasingly complex system?
- Author
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Adler JT and Husain SA
- Subjects
- Humans, Waiting Lists, Tissue and Organ Procurement, Organ Transplantation
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- 2022
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10. Access to kidney transplantation among pediatric candidates with prior solid organ transplants in the United States.
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Husain SA, King KL, Owen-Simon NL, Fernandez HE, Ratner LE, and Mohan S
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- Child, Humans, Tissue Donors, United States, Waiting Lists, Kidney Transplantation, Organ Transplantation, Tissue and Organ Procurement, Transplants
- Abstract
Background: Pediatric kidney transplant candidates require timely access to transplant to optimize growth and neurodevelopmental outcomes. We studied access to transplant for pediatric candidates with prior organ transplants., Methods: We used US registry data to identify pediatric kidney transplant candidates added to the waiting list 2015-2019 and used competing risk regression to study the association between prior transplant status and probability of receiving a kidney transplant, treating wait-list removal and death as competing events., Results: Of 4962 pediatric kidney transplant candidates included, 89% had no prior transplant and 11% had received a prior organ transplant (kidney 87%, liver 5%, heart 5%). Prior transplant recipients were older at listing (median 15 vs. 12 years) and more likely to have PRA≥98% (22% vs. 0.3%) (both p < .001). There was no significant difference in the proportion of candidates from each group who were preemptively wait-listed. Unadjusted competing risk regression showed a lower risk of kidney transplant after wait-listing among candidates with prior organ transplant (HR 0.52, 95%CI 0.47-0.59, p < .001). This association remained significant after adjusting for candidate characteristics (HR 0.73, 95%CI 0.63-0.83, p < .001). Among deceased donor kidney recipients, median KDPI was similar between groups, but recipients with prior transplants were more likely to receive kidneys from donors with hypertension (4% vs. 1%, p = .01) and donors after cardiac death (11% vs. 4%, p < .001)., Conclusions: Pediatric kidney transplant candidates with prior organ transplants have reduced access to transplant after wait-listing. Allocation system changes are needed to improve timely access to transplant for this vulnerable group., (© 2022 Wiley Periodicals LLC.)
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- 2022
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11. Improving the Utilization of Deceased Donor Kidneys by Prioritizing Patient Preferences.
- Author
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Mohan S and Husain SA
- Subjects
- Humans, Patient Preference, Tissue Donors, Kidney, Graft Survival, Donor Selection, Kidney Transplantation, Tissue and Organ Procurement
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- 2022
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12. Healthcare students support opt-out organ donation for practical and moral reasons.
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Qian L, Li MT, King KL, Husain SA, Cohen DJ, and Mohan S
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- Delivery of Health Care, Humans, Morals, Students, Tissue Donors, Organ Transplantation, Tissue and Organ Procurement
- Abstract
Background and Purpose: Changes to deceased organ donation policy in the USA, including opt-out and priority systems, have been proposed to increase registration and donation rates. To study attitudes towards such policies, we surveyed healthcare students to assess support for opt-out and priority systems and reasons for support or opposition., Methods: We investigated associations with supporting opt-out, including organ donation knowledge, altruism, trust in the healthcare system, prioritising autonomy and participants' evaluation of the moral severity of incorrectly assuming consent in opt-in systems ('opt-in error') or opt-out systems ('opt-out error'), by conducting an online survey among healthcare students at a large academic institution., Results: Of 523 respondents, 86% supported opt-out, including 53% who strongly supported the policy. The most popular reason for supporting opt-out was the potential for increased donation rates, followed by convenience for those not registered but willing to donate. The most popular reason for opposing opt-out was the belief that presuming consent is morally wrong. Those strongly supporting opt-out viewed the opt-in error as more morally unacceptable, and had higher knowledge and altruism scores. Those opposing opt-out viewed the opt-out error as more unacceptable, and had higher autonomy scores. 48% of respondents supported priority within opt-in systems; 31% supported priority in opt-out., Conclusions: There is strong support for opt-out organ donation among healthcare students, influenced by both practical and moral considerations., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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13. Association of transplant center market concentration and local organ availability with deceased donor kidney utilization.
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Husain SA, King KL, Cron DC, Neidlinger NA, Ng H, Mohan S, and Adler JT
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- Humans, Kidney, Tissue Donors, Kidney Transplantation, Tissue and Organ Procurement, Transplants
- Abstract
Although there is a shortage of kidneys available for transplantation, many transplantable kidneys are not procured or are discarded after procurement. We investigated whether local market competition and/or organ availability impact kidney procurement/utilization. We calculated the Herfindahl-Hirschman Index (HHI) for deceased donor kidney transplants (2015-2019) for 58 US donation service areas (DSAs) and defined 4 groups: HHI ≤ 0.32 (high competition), HHI = 0.33-0.51 (medium), HHI = 0.53-0.99 (low), and HHI = 1 (monopoly). We calculated organ availability for each DSA as the number kidneys procured per incident waitlisted candidate, grouped as: <0.42, 0.42-0.69, >0.69. Characteristics of procured organs were similar across groups. In adjusted logistic regression, the HHI group was inconsistently associated with composite export/discard (reference: high competition; medium: OR 1.16, 95% CI 1.11-1.20; low 1.01, 0.96-1.06; monopoly 1.19, 1.13-1.26) and increasing organ availability was associated with export/discard (reference: availability <0.42; 0.42-0.69: OR 1.35, 95% CI 1.30-1.40; >0.69: OR 1.83, 95% CI 1.73-1.93). When analyzing each endpoint separately, lower competition was associated with higher export and only market monopoly was weakly associated with lower discard, whereas higher organ availability was associated with export and discard. These results indicate that local organ utilization is more strongly influenced by the relative intensity of the organ shortage than by market competition between centers., (© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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- 2022
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14. The role of bypass filters in deceased donor kidney allocation in the United States.
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King KL, Husain SA, Cohen DJ, Schold JD, and Mohan S
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- Donor Selection, Humans, Kidney, Tissue Donors, United States, Waiting Lists, Kidney Transplantation, Tissue and Organ Procurement, Transplants
- Abstract
Kidney transplant centers set organ offer filters enabling all candidates at their center to be bypassed during allocation of deceased donor kidneys from the UNOS Organ Center. These filters aim to increase allocation efficiency by preemptively screening out offers unlikely to be accepted. National data were used to compare filter settings of 175 centers in 2007 and in 2019. We examined characteristics of centers whose settings became increasingly restrictive over time, and associations between filter settings and organ offer acceptance. Overall, centers became more open to receiving offers over time, from a median 62% of filters open to receiving national offers in 2007 to 73% in 2019. Intravenous drug use filter settings changed most, from 63 to 153 willing centers. Centers with more open filter settings had higher transplant volume and offer acceptance ratios across all risk categories despite preemptively screening out fewer offers compared to centers with less open settings, but similar transplant rates. There was significant geographic heterogeneity in the distribution of centers with more open filter settings. Current center bypass filters may impact patients' access to transplantation without achieving their full potential for improving allocation efficiency., (© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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- 2022
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15. Deceased donor kidneys allocated out of sequence by organ procurement organizations.
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King KL, Husain SA, Perotte A, Adler JT, Schold JD, and Mohan S
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- Humans, Kidney, Tissue Donors, Kidney Transplantation, Tissue and Organ Procurement, Transplants
- Abstract
Deceased donor kidney allocation follows a ranked match-run of potential recipients. Organ procurement organizations (OPOs) are permitted to deviate from the mandated match-run in exceptional circumstances. Using match-run data for all deceased donor kidney transplants (Ktx) in the US between 2015 and 2019, we identified 1544 kidneys transplanted from 933 donors with an OPO-initiated allocation exception. Most OPOs (55/58) used this process at least once, but 3 OPOs performed 64% of the exceptions and just 2 transplant centers received 25% of allocation exception Ktx. At 2 of 3 outlier OPOs these transplants increased 136% and 141% between 2015 and 2019 compared to only a 35% increase in all Ktx. Allocation exception donors had less favorable characteristics (median KDPI 70, 41% with history of hypertension), but only 29% had KDPI ≥ 85% and the majority did not meet the traditional threshold for marginal kidneys. Allocation exception kidneys went to larger centers with higher offer acceptance ratios and to recipients with 2 fewer priority points-equivalent to 2 less years of waiting time. OPO-initiated exceptions for kidney allocation are growing increasingly frequent and more concentrated at a few outlier centers. Increasing pressure to improve organ utilization risks increasing out-of-sequence allocations, potentially exacerbating disparities in access to transplantation., (© 2022 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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- 2022
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16. Factors that Influence Organ Donor Registration Among Asian American Physicians in Queens, New York.
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Li MT, Hillyer GC, Kim DW, King KL, Husain SA, and Mohan S
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- Asian, Health Knowledge, Attitudes, Practice, Humans, New York, Surveys and Questionnaires, Tissue Donors, United States, Physicians, Tissue and Organ Procurement
- Abstract
Organ donation rates in the United States are lowest among Asians. Physicians are highly respected in Asian communities and may be influential in promoting donor registration, but little is known about their organ donor registration attitudes. We assessed associations between knowledge, attitudes, personal/professional experience, cultural/religious beliefs surrounding organ donation and donor registration status using multivariable logistic regression. We surveyed 121 Asian physicians in Queens, New York; 22% were registered donors. Registered donors were more likely to discuss donation wishes with their family (OR 9.47, 95% CI 2.60-34.51), know that donor human leukocyte antigen does not need to match organ recipients (OR 6.47, 95% CI 1.66-25.28), and have experience advising patients about organ donation (OR 5.35, 95% CI 1.50-19.02). Culturally tailored educational materials providing updated information to promote family discussion about organ donation could potentially increase Asian physicians' level of comfort and expertise in discussing organ donor registration with patients., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2022
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17. Impact of Extending Eligibility for Reinstatement of Waiting Time After Early Allograft Failure: A Decision Analysis.
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Husain SA, King KL, Adler JT, Mohan S, and Perotte R
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- Allografts, Decision Support Techniques, Graft Survival, Humans, Tissue Donors, United States, Waiting Lists, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
Rationale & Objective: The shortage of deceased donor kidneys identified for potential transplantation in the United States is exacerbated by a high proportion of deceased donor kidneys being discarded after procurement. We estimated the impact of a policy proposal aiming to increase organ utilization by extending eligibility for waiting time reinstatement for recipients experiencing early allograft failure after transplantation., Study Design: Decision analysis informed by clinical registry data., Setting & Population: We used Organ Procurement and Transplantation Network data to identify 76,044 deceased-donor kidneys procured in the United States from 2013 to 2017, 80% of which were transplanted and 20% discarded., Intervention: Extend waiting time reinstatement for recipients experiencing allograft failure from the current 90 days to 1 year after transplantation., Outcome: Net impact to the waitlist, defined as the estimated number of additional transplants minus estimated increase in waiting list reinstatements., Model, Perspective, & Timeframe: We estimated (1) the number of additional deceased donor kidneys that would be transplanted if there was a 5%-25% relative reduction in discards, and (2) the number of recipients who would regain waiting time under a 6-, 12-, 18-, and 24-month reinstatement policy., Results: Reinstating a waiting time for recipients experiencing allograft failure up to 1 year after transplantation yielded more additional transplants than growth in additions to the waiting list for all model assumptions except the combination of a very low relative reduction in discards (5%) and a very high failure rate of transplanted kidneys that would previously have been discarded (≥5 times the rate of currently transplanted kidneys)., Limitations: Lack of empirical evidence supporting the proposed impact of such a policy change., Conclusions: A policy change reinstating waiting time for deceased donor kidneys recipients with allograft failure up to 1 year after transplantation should explored as a decision science-based intervention to improve organ utilization., (Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
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- 2022
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18. Role of deceased donor kidney procurement biopsies in organ allocation.
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Jadav P, Mohan S, and Husain SA
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- Biopsy, Donor Selection, Humans, Kidney, Tissue Donors, United States, Kidney Transplantation adverse effects, Tissue and Organ Procurement
- Abstract
Purpose of Review: There has been an increased emphasis by the transplant community and the federal government to increase the utilization of deceased donor kidneys. Procurement biopsies during allocation are the most common reason for kidney discards. This manuscript reviews the evidence of procurement biopsies practices and utility., Recent Findings: Procurement biopsies are performed in over half of all the kidneys recovered in the United States and account for more than one third of the kidney discards. However, there is a significant heterogeneity across the organ procurement organizations regarding the indications for biopsy, biopsy techniques and their reporting. Procurement biopsy findings are not reproducible and poorly correlate to postimplantation histology, although reasons for these limitations are not clear. Procurement biopsy findings are not associated with posttransplant outcomes after accounting for readily available donor clinical characteristics., Summary: Procurement biopsies contribute to deceased donor kidney discards but do not predict posttransplant outcomes. Research to establish the best practices for procurement biopsies is needed to improve organ utilization., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2021
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19. Variations in deceased donor kidney procurement biopsy practice patterns: A survey of U.S. organ procurement organizations.
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Emmons BR, Husain SA, King KL, Adler JT, and Mohan S
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- Biopsy, Humans, Kidney, Reproducibility of Results, Tissue Donors, United States, Tissue and Organ Procurement
- Abstract
Background: Procurement biopsies have become a common practice in the evaluation and allocation of deceased donor kidneys in the United States despite questions about their value and reproducibility. We sought to determine the extent of OPO-level differences in criteria used to decide which deceased donor kidneys undergo a procurement biopsy and to assess the degree of variability in procurement biopsy technique and interpretation across OPOs., Methods: Each of the country's 58 OPOs were invited to participate in the survey. OPOs were divided into two groups based on organ availability ratio and deceased donor kidney discard rate., Results and Conclusions: Fifty-out-of-fifty-eight invited OPOs (86% response rate) responded to the survey between November 2020 and December 2020. Thirty (60%) OPOs reported that they have formal criteria for performing kidney procurement biopsy, but for 29 of these OPOs, transplant centers can request biopsy on kidneys that do not meet criteria. OPOs used a total of seven different variables and 12 different numerical thresholds to define impaired kidney function that would prompt a procurement biopsy. Additionally, wide variability was seen in biopsy technique and procedures for biopsy interpretation and reporting of findings to transplant programs. These findings identify a clear opportunity for standardization of procurement biopsies to best practices., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2021
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20. Association between procurement biopsy findings and deceased donor kidney outcomes: a paired kidney analysis.
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Husain SA, King KL, Coley S, Natarajan K, Perotte A, and Mohan S
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- Biopsy, Donor Selection, Graft Survival, Humans, Kidney, Tissue Donors, Treatment Outcome, United States, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
Unfavourable procurement biopsy findings are the most common reason for deceased donor kidney discard in the United States. We sought to assess the association between biopsy findings and post-transplant outcomes when donor characteristics are accounted for. We used registry data to identify 1566 deceased donors of 3132 transplanted kidneys (2015-2020) with discordant right/left procurement biopsy classification and performed time-to-event analyses to determine the association between optimal histology and hazard of death-censored graft failure or death. We then repeated all analyses using a local cohort of 147 donors of kidney pairs with detailed procurement histology data available (2006-2016). Among transplanted kidney pairs in the national cohort, there were no significant differences in incidence of delayed graft function or primary nonfunction. Time to death-censored graft failure was not significantly different between recipients of optimal versus suboptimal kidneys. Results were similar in analyses using the local cohort. Regarding recipient survival, analysis of the national, but not local, cohort showed optimal kidneys were associated with a lower hazard of death (adjusted HR 0.68, 95% CI 0.52-0.90, P = 0.006). In conclusion, in a large national cohort of deceased donor kidney pairs with discordant right/left procurement biopsy findings, we found no association between histology and death-censored graft survival., (© 2021 Steunstichting ESOT. Published by John Wiley & Sons Ltd.)
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- 2021
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21. Left-digit bias and deceased donor kidney utilization.
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Husain SA, King KL, and Mohan S
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- Adult, Bias, Donor Selection, Graft Survival, Humans, Kidney, Risk Factors, Tissue Donors, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
Cognitive biases shown to impact medical decision-making include left-digit bias, the tendency to focus on a continuous variable's leftmost digit. We hypothesized that left-digit bias impacts deceased donor kidney utilization through heuristic processing of donor age and creatinine. We used US registry data to identify 87 019 kidneys recovered (2015-2019) and compared the proportion around thresholds for donor age (69 vs. 70 years) and creatinine (1.9 vs. 2.0 mg/dl), then compared the risk of kidney discard. Kidneys from donors aged 70 vs. 69 years were more frequently discarded (77% vs. 65%, p < .001), with higher risk of discard even after adjusting for KDRI (adjusted RR 1.11, 95% CI 1.02-1.21, p = .018). Similarly, kidneys from donors with final creatinine 2.0 vs. 1.9 mg/dl were more frequently discarded (37% vs. 29%, p < .001), with higher risk of discard after adjusting for KDRI (adjusted RR 1.19, 95% CI 1.07-1.33, p = .001). However, no significant left-digit effect was found when examining other donor age (39/40, 49/50, 59/60 years) or creatinine (0.9/1.0, 2.9/3.0 mg/dl) thresholds. The findings suggest a possible left-digit effect affecting kidney utilization at specific thresholds. Additional investigations of the impact of this and other heuristics on organ utilization are needed to identify potential areas for decision-making interventions aimed at reducing kidney discard., (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2021
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22. Greater complexity and monitoring of the new Kidney Allocation System: Implications and unintended consequences of concentric circle kidney allocation on network complexity.
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Adler JT, Husain SA, King KL, and Mohan S
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- Humans, Kidney, Tissue Donors, United States, Waiting Lists, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
The deceased donor kidney allocation system in the United States has undergone several rounds of iterative changes, but these changes were not explicitly designed to address the geographic variation in access to transplantation. The new allocation system, expected to start in December 2020, changes the definition of "local allocation" from the Donation Service Area to 250 nautical mile circles originating from the donor hospital. While other solid organs have adopted a similar approach, the larger number of both kidney transplant centers and transplant candidates is likely to have different consequences. Here, we discuss the incredible increase in complexity in allocation, discuss some of the likely intended and unintended consequences, and propose metrics to monitor the new system., (© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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- 2021
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23. Procurement Biopsy Data Quality Limits Comparability of United States and French Deceased Donor Kidney Biopsies.
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Husain SA and Mohan S
- Subjects
- Biopsy, Humans, Kidney, Tissue Donors, United States, Data Accuracy, Tissue and Organ Procurement
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- 2021
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24. Kidney nonprocurement in solid organ donors in the United States.
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Yu K, King K, Husain SA, Dube GK, Stevens JS, Ratner LE, Cooper M, Parikh CR, and Mohan S
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- Donor Selection, Humans, Kidney, Risk Factors, Tissue Donors, United States, Kidney Transplantation, Tissue and Organ Procurement
- Abstract
There are limited data on the nonprocurement of kidneys from solid organ donors. Analysis of Standard Transplant Analysis and Research files was undertaken on all deceased donors in the United States with at least 1 solid organ recovered. From 2000 to 2018, 21 731 deceased donor kidneys (averaging 1144 kidneys per year) were not procured. No kidneys were procured from 8% of liver donors, 3% of heart donors, and 3% of lung donors. Compared to donors with all kidneys procured, those with none procured were older and more likely obese, black, hypertensive, diabetic, hepatitis C positive, smokers, Public Health Service - Increased Risk designated, deceased after cardiac death, or deceased after cerebrovascular accident. Although these donors had lower quality kidneys (median Kidney Donor Risk Index (interquartile range) 1.9 (1.0) vs 1.2 (0.7)), there was substantial overlap in quality between nonprocured and procured kidneys. Nearly one third of nonprocurements were attributed to donor history. Donors with elevated terminal creatinine likely resulting from acute kidney injury (AKI) had higher odds of kidney nonprocurement. Nonprocurement odds varied widely across Organ Procurement and Transplantation Network regions, with a positive correlation between donor kidney nonprocurements and kidney discards at the donation service area level. These findings suggest current discard rates underestimate the underutilization of deceased donor kidneys and more research is needed to optimize safe procurement and utilization of kidneys from donors with AKI., (© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.)
- Published
- 2020
- Full Text
- View/download PDF
25. Major Variation across Local Transplant Centers in Probability of Kidney Transplant for Wait-Listed Patients.
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King KL, Husain SA, Schold JD, Patzer RE, Reese PP, Jin Z, Ratner LE, Cohen DJ, Pastan SO, and Mohan S
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- Adult, Aged, Cohort Studies, Female, Humans, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic epidemiology, Male, Middle Aged, Probability, Time Factors, United States, Kidney Failure, Chronic surgery, Kidney Transplantation statistics & numerical data, Tissue and Organ Procurement organization & administration, Waiting Lists
- Abstract
Background: Geographic disparities in access to deceased donor kidney transplantation persist in the United States under the Kidney Allocation System (KAS) introduced in 2014, and the effect of transplant center practices on the probability of transplantation for wait-listed patients remains unclear., Methods: To compare probability of transplantation across centers nationally and within donation service areas (DSAs), we conducted a registry study that included all United States incident adult kidney transplant candidates wait listed in 2011 and 2015 (pre-KAS and post-KAS cohorts comprising 32,745 and 34,728 individuals, respectively). For each center, we calculated the probability of deceased donor kidney transplantation within 3 years of wait listing using competing risk regression, with living donor transplantation, death, and waiting list removal as competing events. We examined associations between center-level and DSA-level characteristics and the adjusted probability of transplant., Results: Candidates received deceased donor kidney transplants within 3 years of wait listing more frequently post-KAS (22%) than pre-KAS (19%). Nationally, the probability of transplant varied 16-fold between centers, ranging from 4.0% to 64.2% in the post-KAS era. Within DSAs, we observed a median 2.3-fold variation between centers, with up to ten-fold and 57.4 percentage point differences. Probability of transplantation was correlated in the post-KAS cohort with center willingness to accept hard-to-place kidneys ( r =0.55, P <0.001) and local organ supply ( r =0.44, P <0.001)., Conclusions: Large differences in the adjusted probability of deceased donor kidney transplantation persist under KAS, even between centers working with the same local organ supply. Probability of transplantation is significantly associated with organ offer acceptance patterns at transplant centers, underscoring the need for greater understanding of how centers make decisions about organs offered to wait-listed patients and how they relate to disparities in access to transplantation., (Copyright © 2020 by the American Society of Nephrology.)
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- 2020
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26. Impact of warm ischemia time on outcomes for kidneys donated after cardiac death Post-KAS.
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Brennan C, Sandoval PR, Husain SA, King KL, Dube GK, Tsapepas D, Mohan S, and Ratner LE
- Subjects
- Death, Delayed Graft Function etiology, Graft Survival, Humans, Kidney, Risk Factors, Tissue Donors, Treatment Outcome, Tissue and Organ Procurement, Warm Ischemia adverse effects
- Abstract
Prolonged warm (WIT) and cold (CIT) ischemia times are often important considerations in the discard of DCD kidneys, but their impact on post-transplant outcomes in the post-KAS era is unclear. We examined the association of ischemia time on delayed graft function (DGF) and death-censored graft failure for DCD kidneys. The 2018 SRTR SAF was utilized to identify post-KAS DCD kidney transplants occurring from 2015 to 2018. Relative risk and Cox regression were used to calculate risk of delayed graft function and hazard of death-censored graft failure, respectively. We identified 4,680 kidneys from DCD donors transplanted from 2015 to 2018 with recorded WIT and CIT times. Median WIT was 21.0 minutes (IQR 14.0-28.0), and CIT was 18.5 hours (IQR 13.9-23.5). The overall incidence of DGF was 42.7%. In a univariable relative risk regression model, extended CIT (24-30 hours:RR 1.37, 95% CI 1.15-1.77; >30 hours:RR 1.47, 95% CI 1.22-1.77) and WIT (20-40 minutes:RR 1.10, 95% CI 1.03-1.17) were associated with increased risk of DGF. When included in a multivariable model, neither prolonged CIT nor WIT were significantly associated with death-censored graft failure. Prolonged WIT and CIT are associated with increased DGF but not death-censored graft failure in recipients of DCD kidney transplants in the post-KAS era. Extended ischemia alone should not be used as a basis for discard or non-utilization of these organs., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2020
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27. Evaluation of kidney allocation critical data validity in the OPTN registry using dialysis dates.
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Tsapepas D, King KL, Husain SA, and Mohan S
- Subjects
- Humans, Prognosis, Health Care Rationing standards, Kidney Transplantation methods, Registries statistics & numerical data, Renal Dialysis statistics & numerical data, Resource Allocation standards, Tissue and Organ Procurement statistics & numerical data
- Published
- 2020
- Full Text
- View/download PDF
28. Trends in Disparities in Preemptive Kidney Transplantation in the United States.
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King KL, Husain SA, Jin Z, Brennan C, and Mohan S
- Subjects
- Adult, Black or African American statistics & numerical data, Aged, Cadaver, Female, Hispanic or Latino statistics & numerical data, Humans, Male, Middle Aged, Time Factors, Tissue Donors statistics & numerical data, United States, White People statistics & numerical data, Healthcare Disparities statistics & numerical data, Healthcare Disparities trends, Kidney Failure, Chronic surgery, Kidney Transplantation, Tissue and Organ Procurement methods, Tissue and Organ Procurement statistics & numerical data
- Abstract
Background and Objectives: Long wait times for deceased donor kidneys and low rates of preemptive wait-listing have limited preemptive transplantation in the United States. We aimed to assess trends in preemptive deceased donor transplantation with the introduction of the new Kidney Allocation System (KAS) in 2014 and identify whether key disparities in preemptive transplantation have changed., Design, Setting, Participants, & Measurements: We identified adult deceased donor kidney transplant recipients in the United States from 2000 to 2018 using the Scientific Registry of Transplant Recipients. Preemptive transplantation was defined as no dialysis before transplant. Associations between recipient, donor, transplant, and policy era characteristics and preemptive transplantation were calculated using logistic regression. To test for modification by KAS policy era, an interaction term between policy era and each characteristic of interest was introduced in bivariate and adjusted models., Results: The proportion of preemptive transplants increased after implementation of KAS from 9.0% to 9.8%, with 1.10 (95% confidence interval [95% CI], 1.06 to 1.14) times higher odds of preemptive transplantation post-KAS compared with pre-KAS. Preemptive recipients were more likely to be white, older, female, more educated, hold private insurance, and have ESKD cause other than diabetes or hypertension. Policy era significantly modified the association between preemptive transplantation and race, age, insurance status, and Human Leukocyte Antigen zero-mismatch (interaction P <0.05). Medicare patients had a significantly lower odds of preemptive transplantation relative to private insurance holders (pre-KAS adjusted OR, [aOR] 0.26; [95% CI, 0.25 to 0.27], to 0.20 [95% CI, 0.18 to 0.22] post-KAS). Black and Hispanic patients experienced a similar phenomenon (aOR 0.48 [95% CI, 0.45 to 0.51] to 0.41 [95% CI, 0.37 to 0.45] and 0.43 [95% CI, 0.40 to 0.47] to 0.40 [95% CI, 0.36 to 0.46] respectively) compared with white patients., Conclusions: Although the proportion of deceased donor kidney transplants performed preemptively increased slightly after KAS, disparities in preemptive kidney transplantation persisted after the 2014 KAS policy changes and were exacerbated for racial minorities and Medicare patients., (Copyright © 2019 by the American Society of Nephrology.)
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- 2019
- Full Text
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29. Cultural barriers to organ donation among Chinese and Korean individuals in the United States: a systematic review.
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Li MT, Hillyer GC, Husain SA, and Mohan S
- Subjects
- China ethnology, Humans, Korea ethnology, Asian psychology, Tissue and Organ Procurement
- Abstract
Asian Americans have the lowest organ donation registration rates in the United States, and the reason for this is incompletely understood. Aiming to understand the reasons for low organ donation registration rate among Asian Americans, more specifically Chinese and Korean Americans, we conducted a systematic search of databases, websites, and gray literature. Altogether, 34 papers were retained after the assessment of relevance and quality. Commonly reported barriers to organ donation registration among Chinese and Koreans in the literature included lack of knowledge about organ donation, distrust of health-care and allocation system, cultural avoidance of discussion of death-related topics, and desire for intact body mainly stemming from the Confucian concept of filial piety. Strong family values coupled with a cultural reluctance to discuss death-related topics among family members appear to underscore the reluctance to organ donation among Chinese and Koreans. Notably, improved knowledge negatively impacted organ donation intent and religion seemed to play a more important role when making decision about organ donation among Koreans, and the distrust of the allocation system is more prominent among Chinese. This information should be used to inform the development of culturally competent organ donation educational materials., (© 2019 Steunstichting ESOT.)
- Published
- 2019
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30. Association Between Declined Offers of Deceased Donor Kidney Allograft and Outcomes in Kidney Transplant Candidates.
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Husain SA, King KL, Pastan S, Patzer RE, Cohen DJ, Radhakrishnan J, and Mohan S
- Subjects
- Adult, Allografts statistics & numerical data, Allografts transplantation, Case-Control Studies, Female, Health Services Accessibility ethics, Humans, Kidney Failure, Chronic epidemiology, Kidney Transplantation adverse effects, Kidney Transplantation methods, Male, Middle Aged, Outcome Assessment, Health Care, Patient-Centered Care ethics, Tissue Donors classification, Tissue Donors supply & distribution, Tissue and Organ Procurement methods, Transplant Recipients statistics & numerical data, United States epidemiology, Waiting Lists mortality, Allografts supply & distribution, Kidney Failure, Chronic surgery, Kidney Transplantation statistics & numerical data, Tissue Donors statistics & numerical data, Tissue and Organ Procurement statistics & numerical data
- Abstract
Importance: In the United States, substantial disparities in access to kidney transplant exist for wait-listed candidates with end-stage renal disease. The implications of transplant centers' willingness to accept kidney offers for access to transplant and mortality outcomes are unknown., Objective: To determine the outcomes for wait-listed kidney transplant candidates after the transplant center's refusal of a deceased donor kidney offer., Design, Setting, and Participants: This cohort study obtained data from the United Network for Organ Sharing Potential Transplant Recipient data set on all deceased donor kidney offers in the United States made between January 1, 2008, and December 31, 2015. The final study cohort included adult patients who were wait-listed for kidney transplant and received at least 1 allograft offer during the study period (N = 280 041). Data analysis was conducted from June 1, 2018, to March 30, 2019., Exposure: Candidate state of residence., Main Outcomes and Measures: Waiting list outcome event groups included received deceased donor allograft, received living donor allograft, died while on the waiting list, removed from the waiting list without a transplant, or still on the waiting list at the end of follow-up., Results: Among the 280 041 kidney transplant candidates included in the study, the mean (SD) age at wait-listing was 51.1 (13.1) years, and male patients were predominant (171 517 [61.2%]). In this cohort, 81 750 candidates (29.2%) received a deceased donor kidney allograft, 30 870 (11.0%) received a living donor allograft, 25 967 (9.3%) died while on the waiting list, and 59 359 (21.2%) were removed from the waiting list. Overall, 10 candidates with at least 1 previous allograft offer died each day during the study period. Time to first offer was similar for candidates who received deceased donor kidney allograft compared with those who died while waiting (median [interquartile range {IQR}] time, 79 [16-426] days vs 78 [17-401] days, respectively). Deceased donor allograft recipients had a median of 17 offers (IQR, 6-44) over 422 days (IQR, 106-909 days), whereas candidates who died while waiting received a median of 16 offers (IQR, 6-41) over 651 days (IQR, 304-1117 days). Most kidneys (84%) were declined on behalf of at least 1 candidate before being accepted for transplant. As reported by centers, organ or donor quality concerns accounted for 8 416 474 (92.6%) of all declined offers, whereas offers were infrequently refused because of patient-related factors (232 193 [2.6%]), logistical limitations (49 492 [0.5%]), or other concerns. The odds of death after an offer and the median number of offers received prior to death varied considerably by state., Conclusions and Relevance: This study found that transplant candidates appeared to receive a large number of viable deceased donor kidney offers that were refused on their behalf by transplant centers, potentially exacerbating the detrimental consequences of the organ shortage; increased transparency in organ allocation process and decisions may improve patient-centered care and access to kidney transplant.
- Published
- 2019
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31. Deceased Donor Kidneys Are Harder to Place on the Weekend.
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King KL, Husain SA, Cohen DJ, and Mohan S
- Subjects
- Cadaver, Databases, Factual, Humans, Time Factors, Tissue Donors statistics & numerical data, United States, Kidney Transplantation statistics & numerical data, Tissue and Organ Procurement statistics & numerical data
- Published
- 2019
- Full Text
- View/download PDF
32. Outcomes of kidney transplant from deceased donors with acute kidney injury and prolonged cold ischemia time - a retrospective cohort study.
- Author
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Dube GK, Brennan C, Husain SA, Crew RJ, Chiles MC, Cohen DJ, and Mohan S
- Subjects
- Adult, Aged, Cold Ischemia, Creatinine analysis, Delayed Graft Function, Female, Glomerular Filtration Rate, Graft Rejection, Graft Survival, Humans, Kidney Transplantation adverse effects, Male, Middle Aged, Registries, Retrospective Studies, Treatment Outcome, Young Adult, Acute Kidney Injury physiopathology, Kidney Transplantation methods, Organ Preservation methods, Tissue Donors, Tissue and Organ Procurement methods
- Abstract
While deceased donor renal transplants (DDRT) from donors with either acute kidney injury (AKI) or long cold ischemia time (CIT) are associated with increased risk of delayed graft function (DGF), recipients of these kidneys have good patient and allograft survival. There are limited data on whether kidneys with both AKI and long CIT have outcomes similar to kidneys with only one of these insults. Using data from the Scientific Registry of Transplant Recipients, we analyzed transplant outcomes in patients (2005-2015) receiving kidneys with AKI (terminal creatinine ≥2.0 mg/dl) and CIT 24-30 h (n = 1289), 30-36 h (n = 734), and >36 h (n = 614), using kidneys with AKI and CIT <24 h (n = 5434) as a reference. DGF was more common with increasing CIT up to 36 h, then decreased slightly (41.2% vs. 46.8% vs. 52.5% vs. 50.2%, P < 0.001). Death-censored graft survival (DCGS) at 3 years was better with CIT <24 h compared with other groups (92.5% vs. 90.8% vs. 92% vs. 89.2%, P = 0.018). On multivariable analysis, donor creatinine was predictive of DCGS, whereas only CIT >36 h was predictive of DCGS (aHR 1.27, P = 0.03). Recipients transplanted with kidneys with both AKI and long CIT have excellent intermediate-term outcomes., (© 2019 Steunstichting ESOT.)
- Published
- 2019
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33. Procurement Biopsies in the Evaluation of Deceased Donor Kidneys.
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Carpenter D, Husain SA, Brennan C, Batal I, Hall IE, Santoriello D, Rosen R, Crew RJ, Campenot E, Dube GK, Radhakrishnan J, Stokes MB, Sandoval PR, D'Agati V, Cohen DJ, Ratner LE, Markowitz G, and Mohan S
- Subjects
- Adult, Cadaver, Correlation of Data, Female, Humans, Kidney Transplantation, Male, Middle Aged, Prognosis, Retrospective Studies, Tissue Donors, Donor Selection methods, Kidney pathology, Tissue and Organ Procurement methods
- Abstract
Background and Objectives: Biopsies taken at deceased donor kidney procurement continue to be cited as a leading reason for discard; however, the reproducibility and prognostic capability of these biopsies are controversial., Design, Setting, Participants, & Measurements: We compiled a retrospective, single-institution, continuous cohort of deceased donor kidney transplants performed from 2006 to 2009. Procurement biopsy information-percentage of glomerulosclerosis, interstitial fibrosis/tubular atrophy, and vascular disease-was obtained from the national transplant database. Using univariable, multivariable, and time-to-event analyses for death-censored graft survival, we compared procurement frozen section biopsy reports with reperfusion paraffin-embedded biopsies read by trained kidney pathologists ( n =270). We also examined agreement for sequential procurement biopsies performed on the same kidney ( n =116 kidneys)., Results: For kidneys on which more than one procurement biopsy was performed ( n =116), category agreement was found in only 64% of cases ( κ =0.14). For all kidneys ( n =270), correlation between procurement and reperfusion biopsies was poor: overall, biopsies were classified into the same category (optimal versus suboptimal) in only 64% of cases ( κ =0.25). This discrepancy was most pronounced when categorizing percentage of glomerulosclerosis, which had 63% agreement ( κ =0.15). Interstitial fibrosis/tubular atrophy and vascular disease had agreement rates of 82% ( κ =0.13) and 80% ( κ =0.15), respectively. Ninety-eight (36%) recipients died, and 56 (21%) allografts failed by the end of follow-up. Reperfusion biopsies were more prognostic than procurement biopsies (hazard ratio for graft failure, 2.02; 95% confidence interval, 1.09 to 3.74 versus hazard ratio for graft failure, 1.30; 95% confidence interval, 0.61 to 2.76), with procurement biopsies not significantly associated with graft failure., Conclusions: We found that procurement biopsies are poorly reproducible, do not correlate well with paraffin-embedded reperfusion biopsies, and are not significantly associated with transplant outcomes., (Copyright © 2018 by the American Society of Nephrology.)
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- 2018
- Full Text
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34. Outcomes for potential kidney transplant recipients offered public health service increased risk kidneys: A single-center experience.
- Author
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Fernandez HE, Chiles MC, Pereira M, Husain SA, Miko B, Baral P, Dale LA, Patel S, Runge B, Tsapepas D, Sandoval PR, Ratner LE, Cohen DJ, and Mohan S
- Subjects
- Adolescent, Adult, Female, Follow-Up Studies, Health Knowledge, Attitudes, Practice, Humans, Kidney Failure, Chronic surgery, Male, Middle Aged, Patient Safety, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Survival Rate, Transplant Recipients statistics & numerical data, United States, United States Public Health Service, Young Adult, Donor Selection standards, Kidney Failure, Chronic mortality, Kidney Transplantation mortality, Kidney Transplantation standards, Tissue Donors supply & distribution, Tissue and Organ Procurement standards, Waiting Lists mortality
- Abstract
Background: Discard rate of Public Health Service Increased Risk (PHS-IR) organs is high despite the absence of worse kidney transplant outcomes., Methods: We conducted a retrospective, single-center study of PHS-IR kidney offers made to kidney transplant-only potential recipients from 6/2004 to 5/2015. Overall mortality and transplant outcomes between potential recipients were stratified by response to PHS-IR kidney offers. Cox regression and Kaplan-Meier analyses of mortality and allograft failure were performed., Results: A total of 2423 potential recipients were offered a PHS-IR kidney, with 1502 transplanted, with or without a PHS-IR kidney. Predictors of accepting a PHS-IR kidney included higher Estimated Post Transplant Survival (EPTS) score, prior kidney transplant, and lower educational achievement on multivariable analysis (P = 0.025, P = 0.004, P = 0.023). A positive response to a PHS-IR kidney was associated with lower risk of mortality (3.63% vs 11.6%; aHR 0.467, P = 0.0008). PHS-IR kidney recipients had decreased risk of allograft loss compared to non-PHS-IR recipients (P = 0.007), though mortality outcomes were not significantly different based on PHS-IR status (P = 0.38). No transmission of HIV, HBV, or HCV occurred from PHS-IR kidney donors in this cohort., Conclusions: Efforts must be made to increase awareness of the beneficial outcomes of PHS-IR organs to maximize appropriate donor allocation., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2018
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- View/download PDF
35. Kidney transplant offers to deceased candidates.
- Author
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Husain SA, Winterhalter FS, and Mohan S
- Subjects
- Humans, Death, Kidney Transplantation, Resource Allocation standards, Tissue Donors supply & distribution, Tissue and Organ Procurement standards, Waiting Lists mortality
- Published
- 2018
- Full Text
- View/download PDF
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