1. Transformable upconversion metal–organic frameworks for near-infrared light-programmed chemotherapy
- Author
-
Fang Wang, Zhen Li, Jianping Lei, Hanlin Hou, Rengan Luo, and Xiaobo Zhang
- Subjects
Materials science ,Cell Survival ,Infrared Rays ,Energy transfer ,Antineoplastic Agents ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,Mice ,chemistry.chemical_compound ,Drug Delivery Systems ,Cell Line, Tumor ,Fluorescence Resonance Energy Transfer ,Materials Chemistry ,Animals ,Prodrugs ,Tumor growth ,Particle Size ,Metal-Organic Frameworks ,Cell Proliferation ,Near infrared light ,Molecular Structure ,fungi ,Metals and Alloys ,General Chemistry ,Prodrug ,021001 nanoscience & nanotechnology ,Photon upconversion ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Azobenzene ,chemistry ,Ceramics and Composites ,Female ,Metal-organic framework ,Delivery system ,Drug Screening Assays, Antitumor ,0210 nano-technology - Abstract
A transformable upconversion MOF comprising a UCNP core and an azobenzene-based MOF shell is designed for NIR light-modulated chemotherapy. The dual Förster resonance energy transfers (FRETs) involved in this delivery system trigger the transformation of the MOF for drug release and prodrug activation, thus significantly inhibiting the tumor growth and metastasis.
- Published
- 2021