1. Group 2 innate lymphoid cells in patients with nonasthmatic eosinophilic bronchitis.
- Author
-
Zhan, Chen, Liu, Jiaxing, Li, Bizhou, Xu, Rong, Liang, Wanqin, Zhang, Shengfang, Fang, Liman, Zhong, Shuxin, Shaniya Helen de Silva, S. Dushinka, Sivapalan, Dhinesan, Luo, Wei, Wang, Hongyu, Li, Jing, Lai, Kefang, Zhong, Nanshan, Sehmi, Roma, O'Byrne, Paul M, and Chen, Ruchong
- Subjects
INNATE lymphoid cells ,COUGH ,PULMONARY eosinophilia ,BRONCHITIS ,TH2 cells - Abstract
In line with a previous study, we found elevated levels of sputum CD4 SP + sp CRth2 SP + sp T cells compared with HC (Figure 1A; Table S2), suggesting a role for Th2 cells in driving airway eosinophilia in NAEB. Steroid treatment is reported to increase ILC2s cell death, reduce capacity for cell proliferation, and cell trans-differentiation. Brightling CE et al2 reported that NAEB patients had increased proportion of interleukin (IL)-4 SP + sp CD4 SP + sp T cells in bronchoalveolar lavage fluid, suggesting the role of Th2 cells in NAEB. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF