1. Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.
- Author
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Lal KG, Kim D, Costanzo MC, Creegan M, Leeansyah E, Dias J, Paquin-Proulx D, Eller LA, Schuetz A, Phuang-Ngern Y, Krebs SJ, Slike BM, Kibuuka H, Maganga L, Nitayaphan S, Kosgei J, Sacdalan C, Ananworanich J, Bolton DL, Michael NL, Shacklett BL, Robb ML, Eller MA, and Sandberg JK
- Subjects
- Biomarkers blood, Biomarkers metabolism, C-Reactive Protein metabolism, Cohort Studies, HIV-1 physiology, Humans, Immunity, Innate genetics, Interferon Regulatory Factors genetics, Interferon Regulatory Factors metabolism, Lipopolysaccharide Receptors metabolism, Lymphocyte Activation, Mucosal-Associated Invariant T Cells metabolism, Mucosal-Associated Invariant T Cells microbiology, Receptors, Antigen, T-Cell genetics, Receptors, Antigen, T-Cell metabolism, Transcriptome, HIV Infections immunology, Mucosal-Associated Invariant T Cells immunology, Viremia immunology
- Abstract
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.
- Published
- 2020
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