1. Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.
- Author
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Solidoro P, Bellocchia M, Aredano I, Mattei A, Pivetta E, Patrucco F, Boita M, de Blasio F, Brussino L, Rolla G, and Bucca C
- Subjects
- Administration, Inhalation, Adolescent, Adult, Aged, Aged, 80 and over, Asthma complications, Asthma diagnosis, Asthma physiopathology, Biomarkers blood, Cross-Sectional Studies, Disease Progression, Female, Humans, Longitudinal Studies, Lung physiopathology, Male, Middle Aged, Retrospective Studies, Time Factors, Treatment Outcome, Vitamin D blood, Vitamin D Deficiency blood, Vitamin D Deficiency complications, Vitamin D Deficiency diagnosis, Young Adult, Adrenal Cortex Hormones administration & dosage, Asthma drug therapy, Cholecalciferol administration & dosage, Dietary Supplements, Lung drug effects, Vitamin D analogs & derivatives, Vitamin D Deficiency drug therapy
- Abstract
Background: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL., Methods: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation., Results: 25-OHD was low in 111 patients and was negatively related to exacerbations ( p < 0.001), inhaled CS dose ( p = 0.008) and asthma severity ( p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6 ± 1.2 to 1.6 ± 1.1, p < 0.001), circulating eosinophils (from 395 ± 330 to 272 ± 212 10⁶/L, p < 0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction., Conclusions: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation., Competing Interests: The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
- Published
- 2017
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