1. Genetic thrombophilia variants and risk for preeclampsia among American Indians.
- Author
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Best, Lyle G., Dorsam, Sheri T., Nadeau, Melanie, Burd, Larry, and Anderson, Cindy M.
- Subjects
PREECLAMPSIA ,BLOOD platelet disorders ,GENETIC polymorphisms ,ETHNOLOGY ,PUBLIC health ,BLOOD diseases ,BLOOD coagulation factors ,NATIVE Americans ,LONGITUDINAL method ,CASE-control method ,GENOTYPES ,DISEASE complications - Abstract
Objective: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.Methods: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.Results: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.Conclusion: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia. [ABSTRACT FROM AUTHOR]- Published
- 2009
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