1. Clinical significance of the polymerase chain reaction (PCR) assay in chronic HBV carriers.
- Author
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Gerken G, Paterlini P, Kremsdorf D, Petit MA, Manns M, Meyer zum Büschenfelde KH, and Brechot C
- Subjects
- Asia, Southeastern ethnology, Carcinoma, Hepatocellular etiology, Carrier State, DNA, Viral genetics, Defective Viruses genetics, Defective Viruses isolation & purification, Hepatitis B complications, Hepatitis B genetics, Hepatitis B immunology, Hepatitis B Surface Antigens genetics, Hepatitis, Chronic genetics, Hepatitis, Chronic immunology, Humans, Liver Neoplasms etiology, Male, Protein Precursors genetics, Reproducibility of Results, Viral Envelope Proteins genetics, DNA, Viral blood, Hepatitis B diagnosis, Hepatitis, Chronic diagnosis, Polymerase Chain Reaction
- Abstract
PCR was evaluated as a clinical tool for use in accurate identification of the specific etiologic agent in chronic HBV carriers. The method was found to be valuable in diagnosis and for monitoring therapy, as well as for elucidation of genotypic variants of HBV in chronic HBV cases. By this means an HBV defective variant with alterations in the preS1/preS2 sequence was detected and is consequently described here.
- Published
- 1992
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