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13 results on '"Synucleins"'

1. New Findings from Baylor University College of Medicine Describe Advances in Nerve Tissue Proteins (Olfactory Deficit and Gastrointestinal Dysfunction Precede Motor Abnormalities In Alpha- Synuclein G51d Knock- In Mice).

Subjects
NERVE tissue proteins, ENTERIC nervous system, SYNUCLEINS, PARKINSON'S disease
Abstract

A recent study conducted by Baylor University College of Medicine focused on nerve tissue proteins and their role in Parkinson's disease. The research involved creating mice with a specific mutation in the alpha-Synuclein gene, which led to early symptoms such as olfactory deficits and gastrointestinal dysfunction before motor abnormalities appeared. This study sheds light on the progression of Parkinson's disease and may aid in developing future therapies. The research was supported by various organizations and has been peer-reviewed, providing valuable insights into the pathogenesis of PD. [Extracted from the article]

Published
2025

2. New Nerve Tissue Proteins Study Findings Have Been Reported by Investigators at University of Hartford (Astrocytes Initiate Autophagic Flux and Maintain Cell Viability After Internalizing Non-active Native Extracellular A-synuclein).

Subjects
NERVE tissue proteins, TRANSCRIPTION factors, CELL junctions, CELL anatomy, WESTERN immunoblotting
Abstract

A study conducted at the University of Hartford focused on the role of astrocytes in regulating the synaptic environment and degrading extracellular alpha-synuclein (alpha S) to maintain cell viability. The research found that astrocytes can successfully internalize and degrade monomeric non-active alpha S, inducing autophagic flux without causing cell death. This study suggests that astrocytes play a crucial role in managing protein degradation demands in healthy physiological conditions, potentially preventing detrimental alpha S accumulation. [Extracted from the article]

Published
2024

3. Researchers from Van Andel Institute Detail Findings in Nerve Tissue Proteins (Neuropathology In an A-synuclein Preformed Fibril Mouse Model Occurs Independent of the Parkinson's ' S Disease-linked Lysosomal Atp13a2 Protein).

Subjects
NERVE tissue proteins, ALPHA-synuclein, PARKINSON'S disease, SYNUCLEINS, DOPAMINERGIC neurons, RECESSIVE genes
Abstract

Researchers from Van Andel Institute conducted a study on the role of ATP13A2 protein in Parkinson's disease pathology. The study found that ATP13A2 loss did not exacerbate alpha-synuclein pathology, neuronal loss, or motor deficits in mice models. This suggests that selective lysosomal abnormalities resulting from ATP13A2 loss may not play a significant role in alpha-synuclein clearance or propagation in vivo. The research was supported by the West Michigan Neurodegenerative Diseases Program at VAI. [Extracted from the article]

Published
2024

4. Researchers from Johns Hopkins University Detail Findings in Parkinson's Disease (Gba1 E326k Renders Motor and Non-motor Symptoms With Pathological A-synuclein, Tau and Glial Activation).

Subjects
NERVE tissue proteins, CENTRAL nervous system diseases, NEUROLOGICAL disorders, PARKINSONIAN disorders, PARKINSON'S disease
Abstract

Researchers from Johns Hopkins University have conducted a study on Parkinson's Disease, focusing on the role of the GBA1 gene mutation in neuroinflammation and the spread of pathogenic alpha-synuclein in the brain. The study utilized a mutant mouse model to investigate how the Gba1 E326K mutation exacerbates disease pathology by promoting neuroinflammation and alpha-synuclein transmission. The findings suggest potential new therapeutic strategies for Parkinson's disease and related synucleinopathies. The research was funded by various organizations including the NIH National Institute of Neurological Disorders & Stroke and the United States Department of Defense. [Extracted from the article]

Published
2024

5. Studies from University of Pennsylvania Yield New Data on Personalized Medicine (Navigating Through the Complexities of Synucleinopathies: Insights Into Pathogenesis, Heterogeneity, and Future Perspectives).

Subjects
NERVE tissue proteins, SYNUCLEINS, INDIVIDUALIZED medicine, DRUG therapy
Abstract

A recent study from the University of Pennsylvania explores the complexities of synucleinopathies, a group of neurodegenerative disorders characterized by the aggregation of alpha-synuclein. The research highlights the heterogeneity of these disorders and discusses the potential for personalized medicine strategies targeting the unique underlying causes of each synucleinopathy. The findings suggest that understanding the mechanisms of synucleinopathies could lead to more effective interventions in the treatment of neurodegenerative disorders. The study was supported by the NIH National Institute on Aging and the Michael J Fox Foundation, and has been peer-reviewed for accuracy. [Extracted from the article]

Published
2024

6. New Nerve Tissue Proteins Study Results from University of Pennsylvania Described (Multivalency Drives Interactions of Alpha-synuclein Fibrils With Tau).

Subjects
NERVE tissue proteins, TAU proteins, SYNUCLEINS, ALZHEIMER'S disease
Abstract

A recent study conducted at the University of Pennsylvania explored the interaction between two proteins, tau and alpha-synuclein, which are associated with neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. The researchers found that these proteins weakly interact with each other in their monomer forms, but the interaction becomes more pronounced when alpha-synuclein is in its aggregated form. The study suggests that the co-occurrence of tau and alpha-synuclein in disease is more likely to occur through monomer-fiber binding interactions rather than monomer-monomer or co-aggregation. This research provides valuable insights into the underlying mechanisms of neurodegenerative diseases. [Extracted from the article]

Published
2024

7. Findings from University Health Network in the Area of Parkinson's Disease Described (Research Priorities On the Role of A-synuclein In Parkinson's Disease Pathogenesis).

Subjects
PARKINSON'S disease, CENTRAL nervous system diseases, HEALTH care networks, NERVE tissue proteins, NEUROLOGICAL disorders
Abstract

Researchers from the University Health Network in Toronto, Canada have highlighted the need for a better understanding of the role of alpha-synuclein (alpha Syn) in Parkinson's disease. Despite extensive research efforts, the exact role of alpha Syn in the pathogenesis and progression of the disease remains unclear. The International Parkinson and Movement Disorder Society has formed a panel of experts to discuss research priorities and identify potential breakthrough strategies. This research has been peer-reviewed and provides valuable insights into the ongoing efforts to develop disease-modifying therapies for Parkinson's disease. [Extracted from the article]

Published
2024

8. Findings on Parkinsonian Disorders Reported by Investigators at Advanced Brain Monitoring Inc. (Autonomic Dysregulation During Sleep In Parkinsonian Spectrum Disorders - a Proof of Concept).

Subjects
PARKINSONIAN disorders, PARKINSON'S disease, SLEEP disorders, DYSAUTONOMIA, AUTONOMIC nervous system
Abstract

A recent study conducted by Advanced Brain Monitoring Inc. in Carlsbad, California, examined autonomic dysfunction during sleep in patients with Parkinsonian spectrum disorders. The researchers analyzed pulse-rate changes during sleep to measure autonomic nervous system (ANS) dysfunction in patients with alpha-synucleinopathies, such as Lewy Body dementias, Parkinson's disease, and isolated REM Sleep Behavior Disorder. The study found that autonomic activation index (AAI) was decreased in patients with Lewy Body dementias and Parkinson's disease compared to non-Parkinsonian groups. The researchers plan to further incorporate AAI into a multivariate classifier of neurodegenerative disorders based on sleep characteristics acquired in the patient's home. [Extracted from the article]

Published
2023

9. Findings from University Hospital Yields New Findings on Parkinson's Disease (A Light-inducible Protein Clustering System for In Vivo Analysis of Alpha-synuclein Aggregation In Parkinson Disease).

Subjects
PARKINSON'S disease, NERVE tissue proteins, ALPHA-synuclein, CENTRAL nervous system diseases, UNIVERSITY hospitals
Abstract

Keywords: Quebec City; Canada; North and Central America; Basal Ganglia Diseases and Conditions; Brain Diseases and Conditions; Central Nervous System Diseases and Conditions; Health and Medicine; Movement Disorders; Nerve Tissue Proteins; Nervous System Diseases and Conditions; Neurodegenerative Diseases and Conditions; Parkinson's Disease; Parkinsonian Disorders; Proteins; Synucleins; alpha-Synuclein EN Quebec City Canada North and Central America Basal Ganglia Diseases and Conditions Brain Diseases and Conditions Central Nervous System Diseases and Conditions Health and Medicine Movement Disorders Nerve Tissue Proteins Nervous System Diseases and Conditions Neurodegenerative Diseases and Conditions Parkinson's Disease Parkinsonian Disorders Proteins Synucleins alpha-Synuclein 206 206 1 03/23/23 20230324 NES 230324 2023 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on Neurodegenerative Diseases and Conditions - Parkinson's Disease is the subject of a report. Keywords for this news article include: Quebec City, Canada, North and Central America, Basal Ganglia Diseases and Conditions, Brain Diseases and Conditions, Central Nervous System Diseases and Conditions, Health and Medicine, Movement Disorders, Nerve Tissue Proteins, Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Parkinson's Disease, Parkinsonian Disorders, Proteins, Synucleins, alpha-Synuclein, University Hospital. Quebec City, Canada, North and Central America, Basal Ganglia Diseases and Conditions, Brain Diseases and Conditions, Central Nervous System Diseases and Conditions, Health and Medicine, Movement Disorders, Nerve Tissue Proteins, Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Parkinson's Disease, Parkinsonian Disorders, Proteins, Synucleins, alpha-Synuclein. [Extracted from the article]

Published
2023

10. Study Data from University of Kansas Provide New Insights into Nerve Tissue Proteins (Alpha-synuclein and Mechanisms of Epigenetic Regulation).

Subjects
NERVE tissue proteins, ALPHA-synuclein, EPIGENETICS, LEWY body dementia
Abstract

Keywords: Kansas City; State:Kansas; United States; North and Central America; Genetics; Nerve Tissue Proteins; Proteins; Synucleins; alpha-Synuclein EN Kansas City State:Kansas United States North and Central America Genetics Nerve Tissue Proteins Proteins Synucleins alpha-Synuclein 2023 MAR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in Proteins - Nerve Tissue Proteins. Kansas City, State:Kansas, United States, North and Central America, Genetics, Nerve Tissue Proteins, Proteins, Synucleins, alpha-Synuclein Keywords for this news article include: Kansas City, Kansas, United States, North and Central America, Genetics, Nerve Tissue Proteins, Proteins, Synucleins, alpha-Synuclein, University of Kansas. [Extracted from the article]

Published
2023

11. New Nerve Tissue Proteins Study Findings Have Been Reported from National Heart Lung and Blood Institute (NHLBI) (Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular Alpha-synuclein Fibrils).

Subjects
NERVE tissue proteins, SPECTRAL imaging, ALPHA-synuclein, LUNGS, MOLECULAR biology, AMYLOID
Abstract

Bethesda, State:Maryland, United States, North and Central America, Amyloid, Nerve Tissue Proteins, Peptides and Proteins, Proteins, Synucleins, alpha-Synuclein Keywords: Bethesda; State:Maryland; United States; North and Central America; Amyloid; Nerve Tissue Proteins; Peptides and Proteins; Proteins; Synucleins; alpha-Synuclein EN Bethesda State:Maryland United States North and Central America Amyloid Nerve Tissue Proteins Peptides and Proteins Proteins Synucleins alpha-Synuclein 2023 MAR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Investigators discuss new findings in Proteins - Nerve Tissue Proteins. [Extracted from the article]

Published
2023

12. Research from Genentech Inc. Provides New Study Findings on Parkinson's Disease (Anti-a-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease).

Subjects
PARKINSON'S disease, NERVE tissue proteins, ANIMAL models in research, CENTRAL nervous system diseases, BASAL ganglia diseases
Abstract

Keywords: Genentech Inc.; South San Francisco; California; United States; North and Central America; Antibodies; Business; Immunology; Blood Proteins; Immunoglobulins; alpha-Synuclein; Movement Disorders; Health and Medicine; Parkinson's Disease; Nerve Tissue Proteins; Parkinsonian Disorders; Biotechnology Companies; Brain Diseases and Conditions; Basal Ganglia Diseases and Conditions; Central Nervous System Diseases and Conditions; Nervous System Diseases and Conditions; Neurodegenerative Diseases and Conditions; Proteins; Synucleins EN Genentech Inc. South San Francisco California United States North and Central America Antibodies Business Immunology Blood Proteins Immunoglobulins alpha-Synuclein Movement Disorders Health and Medicine Parkinson's Disease Nerve Tissue Proteins Parkinsonian Disorders Biotechnology Companies Brain Diseases and Conditions Basal Ganglia Diseases and Conditions Central Nervous System Diseases and Conditions Nervous System Diseases and Conditions Neurodegenerative Diseases and Conditions Proteins Synucleins Research findings on Parkinson's disease are discussed in a new report. Genentech Inc., South San Francisco, California, United States, North and Central America, Antibodies, Business, Immunology, Blood Proteins, Immunoglobulins, alpha-Synuclein, Movement Disorders, Health and Medicine, Parkinson's Disease, Nerve Tissue Proteins, Parkinsonian Disorders, Biotechnology Companies, Brain Diseases and Conditions, Basal Ganglia Diseases and Conditions, Central Nervous System Diseases and Conditions, Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Proteins, Synucleins. [Extracted from the article]

Published
2023

13. Findings from Howard University Update Understanding of Alzheimer Disease (The Mediating Role of Inflammation In the Relationship Between Alpha-synuclein and Cognitive Functioning).

Subjects
ALZHEIMER'S disease, COGNITIVE ability, ALPHA-synuclein, NERVE tissue proteins, INFLAMMATION
Abstract

According tonews originating from Washington, District of Columbia, byNewsRx correspondents, research stated, "Accumulatingevidence suggests that alpha-synuclein plays a role in thepathophysiology of Alzheimer's disease (AD). Neurodegenerative Diseases and Conditions - AlzheimerDisease Research findings on Neurodegenerative Diseases and Conditions-Alzheimer Disease are discussed in a new report. [Extracted from the article]

Published
2023

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