4 results on '"Ao, Rui"'
Search Results
2. Targeted discovery of clerodane diterpenoids from Tinospora sinensis as immunomodulatory agents.
- Author
-
Ao R, Li MY, Yang FF, Bao J, Zhang JS, and Zhang H
- Subjects
- Molecular Structure, Animals, Plant Stems chemistry, China, Mice, Cell Differentiation drug effects, Cell Proliferation drug effects, Immunomodulating Agents pharmacology, Immunomodulating Agents isolation & purification, Immunomodulating Agents chemistry, Diterpenes, Clerodane pharmacology, Diterpenes, Clerodane isolation & purification, Diterpenes, Clerodane chemistry, Tinospora chemistry, B-Lymphocytes drug effects, Phytochemicals pharmacology, Phytochemicals isolation & purification
- Abstract
Under the guidance of MS/MS-based molecular networking, five new clerodane diterpenoid glucosides, tinosinesides R-V (1-5), along with 15 known diterpenoids (6-20), were isolated from the stems of Tinospora sinensis. Compound 1 represents the first example of diterpenoid bearing a thio sugar and compound 5 is the first 18,19-dinor-clerodane with cis-fused A/B ring. The structures of the new compounds were elucidated by spectroscopic means, and their absolute configurations were established on the basis of time-dependent density functional theory (TD-DFT) based electronic circular dichroism (ECD) calculation and chemical methods. Selected compounds were evaluated for their immunomodulatory effect and several compounds could enhance the proliferation of B lymphocytes. Preliminary mechanistic studies disclosed that 3 could promote B cell generation and inhibit B cell differentiation., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
3. [Case classification in measles surveillance system under the Two-level Logistic Model].
- Author
-
Li H, Ao R, Peng L, Li D, and Zhang J
- Subjects
- Adolescent, Child, Child, Preschool, China epidemiology, Humans, Infant, Infant, Newborn, Logistic Models, Measles epidemiology, Measles prevention & control, Rubella classification, Rubella diagnosis, Scarlet Fever chemically induced, Scarlet Fever classification, Measles diagnosis, Population Surveillance methods
- Abstract
Objective: To study the prevalence rates of Rash and Febrile Illnesses (RFIs) including measles, rubella, scarlet fever, exanthema subitum and the differences among measles and other RFIs to tentatively formulate the logistic regression model through clinical manifestation., Methods: All the suspected cases of measles, rubella, scarlet fever, exanthema subitum reported by the county/prefecture lever hospitals at four counties were collected during March 2011 to February 2012. When setting laboratory confirmed measles as dependent variable and existed symptoms as independent variable, a logistic regression model was formulated and optimal operational point (OOP)chosen, according to the ROC curve., Results: A total number of 551 cases were collected but the consistency of measles diagnosis between clinical and laboratory was not satisfied, with Kappa value = 0.349, same to the diagnosis of rubella. As for the result from the two-lever logistic regression model, symptoms that related to the confirmation of measles would include cough (OR = 5.75), conjunctivitis (OR = 3.00), Koplik spot (OR = 7.52), lymphadenectasis(OR = 0.07), rash after fever (OR = 0.07). The area under ROC curve was 0.97 and the optimal operational point was 0.249., Conclusion: A logistic regression model was formulated using the clinical symptoms which was resulted in better performance on prediction. As the sample size of this survey was small, the expansion on the scale of investigation and laboratory testings were needed before the types and components of measles-related RFIs be clarified.
- Published
- 2014
4. [A seroepidemiologic analysis of hepatitis B in Sichuan province].
- Author
-
Du F, Liu QL, Fu QP, Sun L, Ao R, Guan XJ, Liu Y, Wang J, He H, Tong WB, Qin ZY, Fan WJ, Li J, He JL, and Fang G
- Subjects
- Adolescent, Adult, Child, Child, Preschool, China epidemiology, Hepatitis B Antibodies blood, Hepatitis B Surface Antigens blood, Hepatitis B Vaccines administration & dosage, Humans, Infant, Middle Aged, Prevalence, Sampling Studies, Seroepidemiologic Studies, Young Adult, Hepatitis B epidemiology
- Abstract
Objective: To understand the changes of hepatitis B infection rates, before and after the hepatitis B vaccine was included into EPI, and to evaluate the effect of immunization which would lead to the development of a more appropriate hepatitis B control strategy., Methods: Seroepidemiologic method, with multi-section random sampling method were chosen. 14 sites from 8 counties were involved. 2-4 ml of the vein blood was drawn from all the individuals engaged in the study including 3806 samples. HBsAg, anti-HBs, anti-HBc of the samples were tested with ELISA., Results: Standardized positive rates of HBsAg and HBsAb were found as 7.05% and 29.77% respectively with the overall infection rate of HBV as 40.30%. The hepatitis B vaccine coverage of the children under 15 years was 70.73% and the positive rates for both HBsAg and anti-HBs were 2.62% and 56.68%, respectively. The coverage of hepatitis B vaccine among children under 3 years was 83.44% and the positive rates of both HBsAg and anti-HBs were 1.47% and 67.69% respectively, hepatitis B vaccine coverage of children under 3 years was 85.77%, with positive rates of HBsAg and anti-HBs as 1.78% and 75.44% respectively., Conclusion: Results from our study revealed that since the introduction of hepatitis B vaccination, the prevalence rates of HBsAg and HBV infection had an obvious decline, especially in children aged under 15 years of old, suggesting that some changes had occurred in the epidemic characteristics of hepatitis B in Sichuan.
- Published
- 2009
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.