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A massive eruption of Okmok volcano in Alaska has been recently discovered and precisely dated to have occurred in 43 BCE. Some Chinese climate records of 43–33 BCE in historical documents have been found that provide descriptions of observed environmental abnormities that appear to be consistent with the anticipated changes due to volcanic climate forcing. We provide full translation with discussions of the Chinese climate records that may be related to the Okmok eruption in this paper. We have converted ancient Chinese calendar dates to modern Gregorian dates and provided the latitudes and longitudes of the geographical locations mentioned in the records. We believe the detailed information contained in these records will be useful for further research on the climate impact of volcanic eruptions. [ABSTRACT FROM AUTHOR]

Objective: To identify levels of moderate-intensity physical activity (MPA) and vigorous-intensity physical activity (VPA) in a representative sample of college students in six East Asian economies and examine their relationship with weight, alcohol consumption and cigarette smoking. Design: Cross-sectional survey. Setting: College students recruited from 21 different colleges in six East Asian economies. Method: Self-reported physical activity, weight, height, alcohol consumption, and smoking were assessed using already-validated instruments. Multiple logistic regression models of MPA and VPA were separately performed for each economy, controlling for age, gender, living area before college, military experience, paid employment, and religion. All the analyses were performed using SAS 9.2 with clustering effects accounted for. Results: Being a heavy drinker increased the odds of engaging in VPA in five economies (adjusted odds ratio [AOR] = 1.56 to 2.65). Cigarette smoking was not associated with MPA in any economy and was only associated with VPA in China (AOR = 1.54) and Taiwan (AOR = 1.48), indicating that smokers are more likely to engage in VPA than non-smokers. Conclusions: The relationship between college students' VPA and alcohol consumption and between MPA and cigarette smoking is similar across the East Asian economies, whereas the relationship between VPA and smoking varies substantially.

The COVID-19 pandemic has become increasingly worse worldwide since it was discovered in China in late December 2019. Easy contact transmission between people and a low to moderate mortality rate may cause failure in medical health services if there is no proper personal protective equipment for personnel. During the pandemic, patients with acute ischemic stroke with large-vessel occlusion who required immediate treatment through mechanical thrombectomy (MT) were still being sent to the emergency room. Knowing how to maintain effective treatment standards has become our concern. We used a retrospective, single-center study to select COVID-19 (-) patients with acute ischemic stroke undergoing mechanical thrombectomy during the years 2020–2021. Patients with acute ischemic stroke with large-vessel occlusion received mechanical thrombectomy were compared with patients admitted from December 2020 to May 2021 (the pre-COVID-19 group) and those from June 2021 to November 2021 (the during COVID-19 group). Furthermore, the time disparity of mechanical thrombectomy was compared between these two groups. Of patients confirmed with acute ischemic stroke (AIS) with large-vessel occlusion (LVO) during the study period, 62 were included. Compared with the pre-COVID-19 group (34 patients; median age, 70.5 years), the during COVID-19 group (28 patients; median age, 71.5 years) showed no major median time difference in door-to-computed-tomography-angiography (CTA) time (19.0 min vs. 20.0 min, p = 0.398) and no major median time difference in door-to-groin-puncture time (118.0 min vs. 109.0 min, p = 0.281). In our study, with a prepared protocol for the pandemic having been established in the healthcare system, we could see no difference between the pre-pandemic and during-pandemic time periods when using mechanical thrombectomy to treat COVID-19 (-) patients of AIS with LVO. By means of a quick-PCR test during triage, there was no time delay to perform MT or any lowering of safety protocol for workers in the healthcare system. [ABSTRACT FROM AUTHOR]

• The titer of a PR8-derived clade 2·3·4·4a H5N8 virus in chicken embryo was very low. • H103Y mutation in HA increased virus titer in chicken embryo and thermo-stability. • H103Y mutation increased mammalian pathogenicity of the virus as reported. • Replacement of PR8 and a prototypic PB2 genes removed the pathogenicity. • The safe and productive virus protected chickens from fatal H5N6 virus challenge. The clade 2·3·4·4 H5Nx is a highly pathogenic avian influenza (HPAI) virus, which first appeared in China and has spread worldwide since then, including Korea. It is divided into subclades a - d, but the PR8-derived recombinant clade 2·3·4·4 a viruses replicate inefficiently in embryonated chicken eggs (ECEs). High virus titer in ECEs and no mammalian pathogenicity are the most important prerequisites of efficacious and safer vaccine strains against HPAI. In this study, we have synthesized hemagglutinin (HA) and neuraminidase (NA) genes based on the consensus amino acid sequences of the clade 2·3·4·4a and b H5N8 HPAIVs, using the GISAID database. We generated PR8-derived H5N8 recombinant viruses with single point mutations in HA and NA, which are related to efficient replication in ECEs. The H103Y mutation in HA increased mammalian pathogenicity as well as virus titer in ECEs, by 10-fold. We also successfully eradicated mammalian pathogenicity in H103Y-bearing H5N8 recombinant virus by exchanging PB2 genes of PR8 and 01310 (Korean H9N2 vaccine strain). The final optimized H5N8 vaccine strain completely protected against a heterologous clade 2·3·4·4c H5N6 HPAIV in chickens, and induced hemagglutination inhibition (HI) antibody in ducks. However, the antibody titer of ducks showed age-dependent results. Thus, H103Y and 01310PB2 gene have been successfully applied to generate a highly productive, safe, and efficacious clade 2·3·4·4 H5N8 vaccine strain in ECEs. [ABSTRACT FROM AUTHOR]

Purpose - The purpose of this study is to use current literature in conjunction with the insights from a detailed analysis of current practice to clarify and extend the knowledge of networks of clusters. Design/methodology/approach This research is an exploratory study of duster formation and global competitiveness. By applying cluster and network theory, this study examines critical elements of high-technology networks and clusters. A case study of two clusters in Taiwan and two in China reveals both intra- and inter-cluster network relationships. Findings - This research concludes that networks of clusters do exist and they carry potential advantages for both firms' and clusters' competitive advantage and innovation. Close network relationships and interdependences of industrial clusters have contributed significantly to the competitiveness of high-technology clusters in the Asia-Pacific region. Research limitations/implications Further research is needed to determine what conditions best promote inter-cluster networks and when such networks are likely to generate the most value. Practical implications First, the relationship among firms in an industrial cluster may be viewed as not only extended supply chains but also as more complex network forms. Firms in a cluster may work together to co-evolve for the purpose of enhancing competitiveness. This process is worthy of further attention from managers looking to more rapidly develop the competitiveness of their firms. Second, the industrial clusters offer a relatively favorable environment that allows the participating firms to more easily pool the resources, investments, and synergies necessary for them to become competitive in the global arena. Third, to the extent that specialization may increase comparative advantage, an industrial cluster can concentrate firms and industries in a region dedicated to a particular product or competence. Finally, once a cluster successfully pools the resources and develops the core products and competences, the phenomena of networks of clusters is likely to emerge for participating parties to share complementarities across both national and geographical boundaries. Originality/value- Most studies on high-technology clusters are focused on intra-cluster interaction. This study broadens the scope of analysis to explore the inter-cluster network structure that enhances global competitiveness of both firms and clusters in an effective and efficient manner. This study offers initial empirical evidences and a number of important insights to assist managers and policy makers in enhancing global competitive advantage. [ABSTRACT FROM AUTHOR]

The Korean economy has been significantly affected by the emergence of China. It is now the largest market for Korean exports and a major supplier of its low-cost imports but has at the same time become a serious challenger to Korea in the world markets for manufacturing exports. This paper investigates changes in China's export structure and its effect on Korea, and bilateral trade between the two. It also examines the motives for Korean investment in China and its effect on bilateral trade and cross-border production networks. [ABSTRACT FROM AUTHOR]

Analyzes a survey which was conducted to determine the problems and profitability of joint ventures and direct foreign investment (DFI) in China. Change in China's economic policy in 1978; Increase of direct foreign investment in China in 1979; Forms of DFI in China.

Investigates the future prospects of trade between South Korea and China, with focus on the Bohai region of China. Trade patterns of China, Bohai, and Korea; Similarity of trade patterns between these countries; Implementation of economic reforms by China in the 1970s; Information on China's development strategy.

In this study, we investigate the impact of the seaport on host city's economic development. Based on data from 41 major port cities in China over the period 2003-2010, our econometric analysis shows that port cargo throughput has a positive effect on the economic growth of the host city. In addition, the competing ports in the neighborhood have an even larger positive association with the local port city. Through examining some of the most dynamic ports in the world, this study provides a renewed understanding of the economic importance of seaports. [ABSTRACT FROM AUTHOR]

Background: The widespread use of electronic health records in the clinical and biomedical fields makes the removal of protected health information (PHI) essential to maintain privacy. However, a significant portion of information is recorded in unstructured textual forms, posing a challenge for deidentification. In multilingual countries, medical records could be written in a mixture of more than one language, referred to as code mixing. Most current clinical natural language processing techniques are designed for monolingual text, and there is a need to address the deidentification of code-mixed text., Objective: The aim of this study was to investigate the effectiveness and underlying mechanism of fine-tuned pretrained language models (PLMs) in identifying PHI in the code-mixed context. Additionally, we aimed to evaluate the potential of prompting large language models (LLMs) for recognizing PHI in a zero-shot manner., Methods: We compiled the first clinical code-mixed deidentification data set consisting of text written in Chinese and English. We explored the effectiveness of fine-tuned PLMs for recognizing PHI in code-mixed content, with a focus on whether PLMs exploit naming regularity and mention coverage to achieve superior performance, by probing the developed models' outputs to examine their decision-making process. Furthermore, we investigated the potential of prompt-based in-context learning of LLMs for recognizing PHI in code-mixed text., Results: The developed methods were evaluated on a code-mixed deidentification corpus of 1700 discharge summaries. We observed that different PHI types had preferences in their occurrences within the different types of language-mixed sentences, and PLMs could effectively recognize PHI by exploiting the learned name regularity. However, the models may exhibit suboptimal results when regularity is weak or mentions contain unknown words that the representations cannot generate well. We also found that the availability of code-mixed training instances is essential for the model's performance. Furthermore, the LLM-based deidentification method was a feasible and appealing approach that can be controlled and enhanced through natural language prompts., Conclusions: The study contributes to understanding the underlying mechanism of PLMs in addressing the deidentification process in the code-mixed context and highlights the significance of incorporating code-mixed training instances into the model training phase. To support the advancement of research, we created a manipulated subset of the resynthesized data set available for research purposes. Based on the compiled data set, we found that the LLM-based deidentification method is a feasible approach, but carefully crafted prompts are essential to avoid unwanted output. However, the use of such methods in the hospital setting requires careful consideration of data security and privacy concerns. Further research could explore the augmentation of PLMs and LLMs with external knowledge to improve their strength in recognizing rare PHI., (©You-Qian Lee, Ching-Tai Chen, Chien-Chang Chen, Chung-Hong Lee, Peitsz Chen, Chi-Shin Wu, Hong-Jie Dai. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 25.01.2024.)

Since the 24-hr PM 2.5 (particle aerodynamic diameter less than 2.5 μm) concentration standard was regulated in Taiwan in 2012, the PM 2.5 concentration has been decreasing year by year, but the ozone (O 3 ) concentration remains almost the same. In particular, the daily maximum 8-hr average O 3 (MDA8 O 3 ) concentration frequently exceeds the standard. The goal of this study is to find a solution for reducing PM 2.5 and O 3 simultaneously by numerical modeling. After the Volatile Organic Compounds (VOC S )-limited and nitrogen oxides (NO X )-limited areas were defined in Taiwan, then, in total, 50 scenarios are simulated in this study. In terms of the average in Taiwan, the effect of VOC S emission reduction is better than that of NO X on the decrease in PM 2.5 concentration, when the same reduction proportion (20%, 40%) is implemented. While the effect of further NO X emission reduction (60%) will exceed that of VOC S . The decrease in PM 2.5 is proportional to the reduction in precursor emissions such as NO X , VOC S , sulfur dioxides (SO 2 ), and ammonia (NH 3 ). The lower reduction of NO X emission for whole Taiwan caused O 3 increases on average but higher reduction can ease the increase, which suggests the implement of NO X emission reductions must be cautious. When comparing administrative jurisdictions in terms of grids, districts/towns, and cities/counties, it was found that controlling NO X and VOC S at a finer spatial resolution of control units did not benefit the decrease in PM 2.5 but did benefit the decrease in O 3 . The enhanced O 3 control strategies obviously cause a higher decrease of O 3 throughout Taiwan due to NO X and VOC S emission changes when they are implemented in the right places. Finally, three sets of short-term and long-term goals of controlling PM 2.5 and O 3 simultaneously are drawn from the comprehensive rankings for all simulated scenarios, depending on whether PM 2.5 or O 3 control is more urgent. In principle, the short-term scenarios could be ordinary or enhanced version of O 3 decrease with lower NO X /VOC S emissions, while the long-term scenario is enhanced version of O 3 decrease plus high emission reductions for all precursors., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Objectives: The association of interleukin-1B (IL-1B)-511 polymorphism with gastric cancer is still controversial, and the association of IL-1B-511 polymorphism with subtypes of gastric cancer is still largely unknown. We investigated whether the association between IL-1B-511 polymorphism and gastric cancer risk varies by clinically important tumor characteristics and the prognostic value of this polymorphism in a large population-based case-control study among Chinese., Methods: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 1,010 gastric cancer patients and 1,500 healthy controls were enrolled in this study. Polymorphism in IL-1B-511 was analyzed by PCR-restriction fragment length polymorphism on 501 gastric cancers and 500 healthy controls., Results: Compared with the CC genotype, carriers of IL-1B-511 TT genotype had an increased gastric cancer risk (odds ratio (OR)=1.97, 95% confidence interval (CI)=1.29-3.01, P=0.0016). TT genotype was significantly associated with intestinal type of gastric cancer (OR=3.16, 95% CI=1.74-5.71, P=0.0001) but not with diffuse or mixed-type gastric cancer. The test for OR heterogeneity between the intestinal-type and non-intestinal-type gastric cancers was statistically significant (P=0.02). In subgroup analyses, TT genotype was found to be associated with poorly differentiated gastric cancer (OR=3.31, 95% CI=1.43-3.60, P<0.0001), but not with moderately or well-differentiated gastric cancer. IL-1B-511 genotypes were not associated with the prognosis of gastric cancer patients., Conclusions: IL-1B polymorphism influences certain subtypes of gastric cancer according to the clinical and pathological features. Understanding the etiologic heterogeneity of gastric cancer may result in improvements in controlling this disorder.

Aerosol is frequently transported by a southward high-pressure system from the Asian Continent to Taiwan and had been recorded a 100% increase in mass level compared to non-event days from 2002 to 2005. During this time period, PM2.5 sulfate was found to increase as high as 155% on event days as compared to non-event days. In this study, Asian emission estimations, Taiwan Emission Database System (TEDS), and meteorological simulation results from the fifth-generation Mesoscale Model (MM5) were used as inputs for the Community Multiscale Air Quality (CMAQ) model to simulate a long-range transport of PM2.5 event in a southward high-pressure system from the Asian Continent to Taiwan. The simulation on aerosol mass level and the associated aerosol components were found within a reasonable accuracy. During the transport process, the percentage of semi-volatile PM2.5 organic carbon in PM2.5 plume only slightly decreased from 22-24% in Shanghai to 21% near Taiwan. However, the percentage of PM2.5 nitrate in PM2.5 decreased from 16-25% to 1%. In contrast, the percentage of PM2.5 sulfate in PM2.5 increased from 16-19% to 35%. It is interesting to note that the percentage of PM2.5 ammonium and PM2.5 elemental carbon in PM2.5 remained nearly constant. Simulation results revealed that transported pollutants dominate the air quality in Taipei when the southward high-pressure system moved to Taiwan. Such condition demonstrates the dynamic chemical transformation of pollutants during the transport process from continental origin over the sea area and to the downwind land.