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This study introduces a novel large three-dimensional physical model experimental system (PMES) for studying the geomechanical problems related to deep underground engineering. The apparatus is mainly composed of a counterforce frame, a hydraulic loading subsystem, a sample installation and transportation subsystem, an excavation subsystem, an integrated monitoring subsystem, and auxiliary facilities. During the design and development of the PMES apparatus, key technological issues were addressed. A high-stiffness frame structure with opening and closing function was developed. Uniform, gradient, and designed non-uniform stresses can be applied with high accuracy. An independent long-term load-holding unit and a surface dynamic disturbance unit were designed. The basic and innovative functions of the apparatus were verified through calibration experiments. A large physical model experiment was conducted to simulate the excavation of a deep-buried drainage tunnel in China's Jinping-II hydropower station. The experiment obtained the failure processes of the surrounding rock masses induced by high in-situ stress, specific engineering geological structures and excavation disturbance. The internal fracturing and strain evolution within the sample were successfully captured by the integrated monitoring subsystem. The results also validated the reliability of this novel apparatus. The development of this novel apparatus provides a new tool for the study of geomechanical problems in deep underground engineering. Highlights: A novel large three-dimensional physical model experimental system for studying the geomechanical problems related to deep underground engineering was established. The basic and innovative functions of the apparatus were verified through calibration experiments. A large physical model experiment was conducted to simulate the excavation of a deep tunnel in China's Jinping-II hydropower station. [ABSTRACT FROM AUTHOR]

In this work, effective thermal conductivity (λEff) of fractured rock masses was numerically investigated. A two-dimensional Discrete Fracture Network (DFN) model of the fractured rock masses was established based on the statistic results of natural fracture development in a potential area for high level radioactive waste disposal in China. Steady state heat transfer processes in the fractured granite rock masses were numerically simulated using finite element method (FEM). The calculated λEff values of the fractured granite rock masses in dry and saturated conditions are 1.99 W/(m K) and 2.31 W/(m K), respectively. Compared with the thermal conductivity of intact granite [λIntact, 2.5 W/(m K)], the drop rates are 20.4% and 7.6%, respectively. Sensitivity analysis was conducted on the main model parameters including fracture density (FDensity), trace length (FLength), thermal contact resistance (FTCR), and λIntact. The results indicate the relation between λEff and three fracture parameters (FDensity, Flength and FTCR) can be fitted using power law or negative exponent functions with good consistency. When fracture network parameters remain unchanged, λEff is in linear positive correlation to λIntact. The slop of the fitted line is determined by the fracture network parameters. Due to the fact that distribution of generated fractures in different directions are quite uniform, λEff did not show significant difference in different directions. On the basis of the above-mentioned results, an estimation model was proposed for the determination of λEff of fractured rock masses using P21 (total length of fracture traces per unit area), FTCR, and λIntact. The proposed estimation model shows good consistency to the calculated results of FEM model. [ABSTRACT FROM AUTHOR]

The natural fracture system exerts a significant influence on the physical and mechanical properties of rock masses. The heat transfer in fractured rock masses is much more complicated than that of intact rock due to the thermal contact resistance induced by natural fractures with varying size, aperture, roughness, and orientation. This work describes a method for determining the representative element volume (REV) of heat transfer and the 3D thermal conductivity tensor of fractured rock masses. The method is based on the element-wise averaging of temperature and heat flux, which can be obtained from a finite element solution to a steady state heat transfer problem with specific boundary conditions. A case study was conducted based on the geological data of a potential area for high level radioactive waste disposal in China. The results indicate that the size of heat transfer REV of the rock masses in the study area is approximately 18 m × 18 m × 18 m. 3D thermal conductivity tensor, the magnitudes and directions of the three principal thermal conductivities, and anisotropy of the fractured rock masses were obtained. Influences of main fracture parameters including density, disc diameter, and thermal contact resistance on the heat transfer characteristics were investigated. The research results in this work can provide a better understanding of the discontinuous heat transfer processes in fractured rock masses and their homogenization methods. [ABSTRACT FROM AUTHOR]

Objective: To analyze the effect of Chinese medicine (CM) on mortality and quality of life (QOL) of acquired immunodefificiency syndrome (AIDS) patients treated with combined antiretroviral therapy (cART).Methods: A random sample of AIDS patients enrolled in the National Chinese Medicine Treatment Trial Program (NCMTP) that met the inclusion criteria was included in this study. NCMTP patients were included as the CM+cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study.Results: The retrospective cohort study included 528 AIDS patients, 322 in the CM+cART group and 206 in the cART group. After 8 years, the mortality in the CM+cART group was 3.3/100 person-years, which was lower than the cART group of 5.3/100 person-years (P<0.05). The hazard ratio (HR) for mortality in the cART group was 1.6 times that of the CM+cART group by Cox proportional hazard model analysis. After controlling for gender, age, marital status, education, and CD4+ T-cell count, the HR was 1.9 times higher in the cART group compared with the CM+cART group (P<0.05). The cross-sectional study investigated 275 AIDS patients. The mean scores of all QOL domains except spirituality/personal beliefs were higher in the CM+cART group than in the cART group (P<0.05).Conclusions: For AIDS patients, CM could help to prolong life, decrease mortality, and improve QOL. However, there were limitations in the study, so prospective studies should be carried out to confifirm our primary results. [ABSTRACT FROM AUTHOR]

• Brittle fracture of deep hard rock was simulated by physical model tests. • The evolution process of brittle fracture in deep tunnels was captured and analysed. • The onset conditions and mechanism of spalling failure in deep tunnels were revealed. • The spalling characteristics were verified by three research methods. Brittle fracture in deep hard rock tunnels in the Jinping laboratory, China, can often endanger the stability of engineering structures. This study describes physical model testing and real-time observations on the evolution process of v-shaped brittle fracture, failure characteristics, onset conditions, and influencing factors in hard rock tunnels. Real-time observations are presented integrated a high-speed camera, acoustic emission system, a digital image correlation, and distributed fiber optic strain sensing technologies. The results show that the process of spalling failure can be divided into two main stages, namely, the instantaneous cracking process in the sidewall surface, and the spalling process of the thin rock chips developing progressively from the excavation boundary to the far field, finally forming stable v-shaped notches. The deviatoric stress of spalling failure in the physical model test satisfies the constant deviatoric stress criterion. The critical strain at spalling failure is consistent with that calculated by the Hoek–Brown strength criterion. Spalling is a form of brittle failure caused by deferential tensile strain. The working face effect is observed in the physical model excavation process. The highest strain caused by overloading occurs near the free surface of the sidewall. The relationship between stress and geometric similarity constants in deep rock engineering is derived. The failure characteristics revealed in the physical model tests are verified by numerical simulations based on cellular automaton theory, which agree well with the experimental results. The research findings can provide theoretical support for the prevention and control of spalling disasters in deep engineering practice. [ABSTRACT FROM AUTHOR]