The main threat to human health from heavy metals is associated with exposure to lead, cadmium, mercury and arsenic. These metals have been extensively studied and their effects on human health have been regularly reviewed by international bodies such as the WHO. Heavy metals have been used by humans for thousands of years. Although several adverse effects of heavy metals on health have been known for a long time, exposure to them continues and is increasing in some parts of the world, particular in under developed countries, though it has declined in developed countries over the last hundred years. Side by side steadily increasing application of radiations in clinical practice, industrial and agricultural activities, residual radio-activity resulting from nuclear test explosions, has a measurable impact contributing to significant radiation hazards in humans. Our increasing dependence on radiation for energy requirement, therapeutic usages and the perceived threat of radiological terrorism has led to the hunt for a safe and effective radiological protective agent worldwide. Toxicity and unwanted side effects of chemical radio protectors at the effective dose level have limited their clinical efficacy, so the focus is on natural plant products and their active constituents which have limited or no toxicity. Adding to this advantage is their easy availability and large scale consumption in one form or the other across the globe. Chemical radioprotection is an important strategy to protect living beings against deleterious effects of radiation. Earlier the synthetic chemical substances, which could minimize the pathological changes in the living system after exposure to ionizing radiation, were looked into. Herbs have always been the principle form of medicine in India. Medicinal plants are the local heritage with global importance. World is enclosed with a rich wealth of medicinal plants. Several Indian medicinal plants (like Tinospora cordifolia, Emblica officinalis, Aloe vera, Ocimum sanctum, Rosemarinus officinalis, Trigonella foenum-graecum, Alstonia scholaris, Panax ginseng and Moringa oleifera etc.) or plant-derived compounds reportedly effective in countering the harmful effects of radiation in different experimental models of radiation injuries were evaluated for their possible role in radiation protection. These herbal plants have been proved to be potent enough to check the radiation and heavy metals induced histopathological, biochemical, histochemical and haematological changes in animal models. [ABSTRACT FROM AUTHOR]