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Anthropogenic activities in the wetland and surrounding land are threatening the waterbirds. Population dynamics and waterbirds' arrival and departure dates are also influenced by wetland characteristics, food availability, and weather conditions. However, this information is rarely available for Taudaha Lake, a small stopover site in the Kathmandu Valley, Nepal, for many north-south migratory waterbirds. We observed the waterbird species, counted their number, and recorded their exact arrival date (October 2019) and departure date from January 2019 to April 2020. In addition, we recorded the air temperature and humidity of the lake during the monitoring time to identify the potential effects of these weathers on the arrival departure of migratory waterbirds. We developed a linear model to understand the factors influencing the arrival and departure of migratory waterbirds. Altogether we recorded ten migratory waterbird species, including one globally threatened species that used Taudaha as a stopover site during their migration. Arrival and departure times vary among the species. With increasing temperature, the migratory bird population decreases at the lake. Despite smaller area, Taudaha Lake at Kathmandu Valley acts as an important stopover site to facilitate the northsouth migration of waterbirds. Therefore, we recommend local government to avoid concrete constructions on the lake. [ABSTRACT FROM AUTHOR]

Introduction: Snake bite poisoning in children is an emergency condition with significant mortality. It is more prevalent in Terai and Inner Terai regions of Nepal especially during monsoon season. There is no study on snake bite poisoning in this part of the country after the introduction of national snake bite management guideline in 2003. This retrospective study was conducted to evaluate the clinicoepidemiological profile, amount of anti-snake venom used and outcome of snake bites. Materials and Methods: Two hundred and forty six cases of snake bite poisoning admitted in emergency department of the hospital up to the age of 14 years, over a period of 6 years from 2004/2005 to 2009/2010 were evaluated retrospectively. Results: The study showed male predominance (57.3%) in snake bites with higher incidence of children above ten years of age (58%). The most of the poisonings (71.9%) was seen during June, July and August months which correspond to the monsoon season in Nepal. Majority of the victims had been bitten by unidentified snakes (52 %), mostly on the fingers & hands (64.6 %). Ptosis was observed in all cases of snake bite poisoning. Slightly less than 1/3rd of the children had respiratory distress needing respiratory support. Average ASV used was 18.2 vials. Case fatality rate (CFR) was quite high (28.2%) with more fatality on those with respiratory distress. Conclusion: As mortality due to snakebite poisoning and consumption of antisnake venom is not reduced by the use of the national protocol 2003, further study to evaluate alternate protocol is recommended. [ABSTRACT FROM AUTHOR]

Fall Armyworm (FAW), Spodoptera frugiperda, is an invasive pest of maize including other cultivated crops such as rice, wheat, and many other vegetables. This invasive species was initially noticed in North-America and later reported in many countries of Africa in early 2016. In South Asia, this has been reported for the first time in India followed by Srilanka in 2018 and Bangladesh, China, Taiwan and Nepal in 2019. It is polyphagous in nature and damage has been reported in more than 80 plant species. The loss has to lead up to 50-80% in maize in severe situation. FAW is a distant flyer and can fly more than 100 km in a night and spread well in crop fields. As this pest is already invasive in many states of India and the likelihood of entry and spreading in Nepal is higher because of the open border between the countries and flexible government quarantine policy. The great socio-economic loss has been forecasted once this pest has received invasive status in Nepal. Recently, this crop has been confirmed by Nepal Agricultural Research Council (NARC) in Gaidakot area of Nawalpur district, Nepal and has been noticed in almost all parts of Nepal such as Sidhuli, Chitwan, Nawalparasi, Tanahun and Rupendehi districts. However, this information has not been endorsed by Nepal Plant Protection Office (NPPO), an official invasive species endorsing organization in Nepal. This species is spreading rapidly in maize growing areas and significant losses have been reported in maize crop by the farmers. The regular scouting, surveillance, and monitoring can be suggested to evaluate the pest status in the crop field. Habitat manipulation with the deployment of deterring crops 'push' such as desmodium (Desmodium uncinatum) and pest-attracting crop 'pull' such as Napier (Pennisetum purpureum) and Sudan grass (Sorghum vulgare sudanense) is suggested in a 'push-pull strategy', the most popular and successful method of FAW management in the maize field. Field sanitation, and conserving pest's natural enemies are other integrated approaches. However, in a commercial maize field, a group of 'soft' and selective chemicals have been suggested for immediate control of this pest. This review compiled the recent informations available on FAW and is useful for farmers, researchers and policy makers to draw a roadmap for the future FAW management in Nepal. [ABSTRACT FROM AUTHOR]

Himalayan lakes represent critical water resources, culturally important waterbodies, and potential hazards. Some of these lakes experience dramatic water-level changes, responding to seasonal monsoon rains and post-monsoonal draining. To address the paucity of direct observations of hydrology in retreating mountain glacial systems, we describe a field program in a series of high altitude lakes in Sagarmatha National Park, adjacent to Ngozumba, the largest glacier in Nepal. In situ observations find extreme (>12 m) seasonal water-level changes in a 60-m deep lateral-moraine-dammed lake (lacking surface outflow), during a 16-month period, equivalent to a 5 × 10 6 m 3 volume change annually. The water column thermal structure was also monitored over the same period. A hydraulic model is constructed, validated against observed water levels, and used to estimate hydraulic conductivities of the moraine soils damming the lake and improves our understanding of this complex hydrological system. Our findings indicate that lake level compared to the damming glacier surface height is the key criterion for large lake fluctuations, while lakes lying below the glacier surface, regulated by surface outflow, possess only minor seasonal water-level fluctuations. Thus, lakes adjacent to glaciers may exhibit very different filling/draining dynamics based on presence/absence of surface outflows and elevation relative to retreating glaciers, and consequently may have very different fates in the next few decades as the climate warms. [ABSTRACT FROM AUTHOR]

Aims: Nepal cannot afford renal replacement therapy (RRT) for ESRD due to lack of resources. Early diagnosis of CKD and its risk factors may reduce the need of RRT. Materials and Methods: In this first community-based screening program in Nepal, 3218 people iÝ 20 years were assessed by door-to-door survey in Dharan. Health status, lifestyle habit, physical examination and blood pressure were evaluated. Spot urine was examined for proteins and glucose by dipstick. Fasting blood glucose and serum creatinine were measured in a subset of 1000 people and the prevalence of CKD was evaluated. A cardiovascular risk factor score was also determined. Results: Overweight, obesity, hypertension, diabetes and proteinuria were found in 20%, 5.0%, 38.6%, 7.5%, and 5.1% respectively. 47% hypertensives were newly detected during the screening. In the subset of 1000 subjects, CKD was detected in 10.6%. Multivariate logistic regression analysis showed that age (P <0.0001) and presence of diabetes (P = 0.027) were statistically significant predictors for CKD. Two or more cardiovascular risk factors were present in 47.3%. 848 patients entered the management phase of the program with lifestyle modification and pharmacologic intervention. 15% drop out during follow-up. Five patients died (2 on RRT). Glycemic (fasting glucose < 120 mg/dL) and blood pressure control (< 140/90 mmHg) was achieved in 60% and 72%, respectively. Regression or stabilization of proteinuria was reported in 52% of patients. Conclusion: Burden of CKD and cardiovascular risk factors are high at community level in Dharan. Reasonable control of blood sugar, hypertension and proteinuria was achieved in this program. These findings indicate the need of activating a large prevention and intervention program to tackle CKD and CVD in Nepal. [ABSTRACT FROM AUTHOR]

Aims: Access to hemodialysis (HD) is limited in Nepal due to geographical terrain and hemodialysis centers being mostly limited to capital city of the country. Therefore, CAPD is likely to be a better option of dialysis in Nepal. In 1998, continuous ambulatory peritoneal dialysis (CAPD) was initiated in Nepal without success. High rate of peritonitis was cited for failure. Hot tropical climate of Nepal along with poor sense of hygiene among patients is thought to be responsible for the high rate of peritonitis. A new CPD program was started in 2002 in our institute. As only center for dialysis in eastern Nepal, the institute serves to around 25% of the population of Nepal. We reviewed the incidence of peritonitis and factors predisposing to peritonitis. Materials and Methods: A total of 30 patients who were initiated on chronic peritoneal dialysis since 2002 to 2005 were included in the study. Two CAPD nursed follow-up this patients and were responsible for the data recording along with resident doctor in dialysis unit. Peritonitis was diagnosed if patient reported cloudy effluent and/or pain abdomen and had dialysate white cell count > 100/mL of which 50% or more were polymorphonuclear leukocytes. All patients were on prophylactic mupirocine ointment. Patients complicated with peritonitis (N = 8) and patients without peritonitis (N=22) were compared. Results: Most patients were male (N=26). Mean duration of dialysis was 12 month per patients (Total patients month= 362). Nine episodes of peritonitis in eight patients were recorded during this period. Six episode of peritonitis were culture positive (staphylocoocus aureous-2, Psedornonous aurigonosae-1, other gram negative organism-2, fungal-1). Culture sterile peritonitis was recorded in 3 episodes (patients). Two patients in each group were shifted to hemodialysis therapy. End stage related due to diabetes mellitus and low serum albumin were predisposing factors for development of peritonitis. Conclusion: Peritonitis is not a limiting factor for growth of CAPD in Nepal. Low serum albumin and diabetes patients are prone for CAPD related peritonitis. [ABSTRACT FROM AUTHOR]

Worldwide Puccinia striiformis f. sp. tritici (Pst) epidemics have been reported to be driven by few genetic lineages, while a high diversity is evident at the Pst Himalayan centre of diversity. This study investigated the relationship between pathotype diversity and genetic structure in Nepal, the eastern Himalayan region, which has been largely unexplored. Despite the high genetic diversity and recombinant structure detected through microsatellite genotyping, characterization of virulence phenotypes for 62 isolates identified only eight pathotypes, with two pathotypes predominant over all the populations. This is in contrast to the Pakistani and Chinese recombinant populations, where high pathotype diversity is associated with genetic diversity. The most prevalent Nepali pathotype was not a unique clonal lineage, but was represented by seven multilocus genotypes from four distinct genetic subgroups, suggesting strong directional selection on virulence genes, resulting in convergent pathotypes in distinct genetic groups. This convergent selection is discussed in comparison with clonal French and recombinant Pakistani populations. Additionally, the Nepali Pst population carried virulence to 17 out of 24 tested yellow rust resistance genes (Yr), with the absence of virulence to Victo and Early Premium and resistance genes Yr5, Yr10, Yr15, Yr24 and Yr26. Virulence to Yr2, Yr7, Yr27 and YrSu were fixed in all isolates, in line with the deployment of these resistance genes in Nepal. The results reflect the influence of resistance gene deployment on selection of virulence and pathotypes in a recombinant pathogen population, which must be considered in the context of durable resistance gene deployment. [ABSTRACT FROM AUTHOR]

Introduction: Physiotherapy as a profession has come a long way over the years. As the treatment of injuries and illness has developed over the decades, the practice has evolved and grown from general forms of physical therapies to specialized physiotherapy services in healthcare settings. Despite the recognition and advances gained worldwide in physiotherapy, yet there is lack of research study in Nepal to evaluate the awareness of physiotherapy among clinical doctors of Nepal. Objective of this study is to investigate the awareness of physiotherapy among clinical doctors working in various hospitals of Nepal. Methods: A cross sectional survey was conducted among the clinical doctors working in various hospitals of Nepal. A questionnaire was randomly distributed among 200 doctors. It comprised of 13 questions related to physiotherapy awareness. Data were collected and statistically analyzed. Results: Among 115 respondents, 98.3% were aware of physiotherapy and 87.8 % of the doctors reported to have physiotherapy services in their hospital. Referral to physiotherapy was found to be 94.8 %. With respect to referrals to physiotherapy in preoperative cases, it was found that 63% of the clinical doctors agreed to refer their patients to physiotherapists. The study also found that 93% of the clinical doctors agreed to refer their patients to physiotherapy post-operatively. Referrals to ICU were agreed by 88% of the doctors involved in this study. Among the clinical doctors surveyed physiotherapy in orthopedic conditions has the maximum awareness (94.8%). The study found that a very small percent of the clinical doctors knew about physiotherapy education in Nepal (39.1%) and Nepal Physiotherapy Association (NEPTA) (33%). Conclusions: The study concluded that the clinical doctors had a good awareness about physiotherapy profession. But awareness needs to be accelerated in terms of referrals and specialized services provided by the physiotherapists for potential benefits of the patients. Physiotherapists as a part of the health care team plays an essential role in reducing the hospital stay, quick recovery and in rehabilitation for a better quality life. [ABSTRACT FROM AUTHOR]

The diversity of agro-environmental conditions among wheat-based farming systems in the mountainous regions of Nepal may favor the development and production of multiple narrowly adapted varieties over a few broadly adapted varieties. Sixteen genotypes were tested using Participatory Varietal Selection (PVS) trials at farmers' fields in three districts in the Kathmandu Valley. Grain yield was the trait most preferred by farmers, followed by tillering, resistance to diseases, drought, and lodging. Farmer selection of optimal genotypes varied over time and location depending on agronomic and climatic pressures, indicating a preference by farmers for growing multiple, narrowly adapted varieties. Production potential of PVS genotypes averaged up to 142% greater than the most widely grown variety, RR21. With farmer participation in the selection process in different agro-ecological micro-niches of Nepal, both yield potential and yield stability of wheat should increase significantly, thereby providing farmers with the economic means to sustain the current small-scale agriculture suited to the mountainous terrain. [ABSTRACT FROM AUTHOR]

Among four ethnic groups in a lowland area of Nepal, the prevalences of abnormal haemoglobin, thalassaemia, glucose-6-phosphate-dehydrogenase (G6PD) deficiency, hereditary South–east Asian ovalocytosis (SAO) and Duffy blood-group antigen Fy/Fy were determined and related to each group's habitat. The group that has lived for many decades in a malaria-endemic lowland area, the Danuwar, was found to have a high prevalence of α+-thalassaemia (79.4%) and low prevalences of haemoglobin E and G6PD deficiency. Much lower prevalences of α+-thalassaemia were observed in the Newar (20.5%), Parbate (16.5%) and Tamang (8.8%), who, until the 1950s, all spent their hot-season nights in malaria-free areas at higher altitudes. No subjects with any other identified abnormal haemoglobin, β-thalassaemia, SAO or Fy/Fy were detected. [ABSTRACT FROM AUTHOR]