1. Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
- Author
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Engsbro AL, Riis Jespersen HS, Goldschmidt MI, Mollerup S, Worning P, Pedersen MS, Westh H, and Schneider UV
- Subjects
- Abdominal Pain etiology, Adult, Agglutination Tests, Anti-Bacterial Agents pharmacology, Bacteremia drug therapy, Carbapenem-Resistant Enterobacteriaceae, Ceftriaxone therapeutic use, Denmark, Drug Resistance, Escherichia coli genetics, Escherichia coli isolation & purification, Female, Fever etiology, Humans, Microbial Sensitivity Tests, Pakistan, Plasmids analysis, Polymerase Chain Reaction, Pregnancy, Salmonella typhi drug effects, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Travel, Typhoid Fever microbiology, Whole Genome Sequencing, Anti-Bacterial Agents therapeutic use, Azithromycin therapeutic use, Ceftriaxone pharmacology, Meropenem therapeutic use, Salmonella typhi genetics, Salmonella typhi isolation & purification, Typhoid Fever diagnosis, Typhoid Fever drug therapy
- Abstract
We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases.
- Published
- 2019
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