77 results on '"Ayten Kadanali"'
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2. Factors Affecting Inadequate Empirical Antimicrobial Therapy and the Clinical Course of Upper Urinary Tract Infections in Elderly Patients: A Multicenter Study
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Pınar KORKMAZ, Behice KURTARAN, Şule ÖZDEMİR ARMAĞAN, Hale TURAN ÖZDEN, Fatma KAÇAR, Selma ATEŞ, Gül DURMUŞ, Fulya BAYINDIR BİLMAN, Yeşim UYGUN KIZMAZ, Aziz Ahmad HAMİDİ, Burcu ÖZDEMİR, Aslıhan BURCU YIKILGAN, Pınar FIRAT, Asuman İNAN, Gülay OKAY, Mehmet Emirhan IŞIK, Ayşe BUT, Kenan UĞURLU, Rezan HARMAN, Büşra ERGÜT SEZER, Elif DOYUK KARTAL, Ferit KUŞÇU, Alper ŞENER, Duru MISTANOĞLU ÖZATAĞ, Elif TÜKENMEZ TİGEN, Özgür DAĞLI, Funda KOÇAK, Hülya KUŞOĞLU, Buket ERTÜRK ŞENGEL, Aslıhan DEMİREL, Hasan NAZ, Canan AĞALAR, Derya ÖZTÜRK ENGİN, İlyas DÖKMETAŞ, Nur CANCAN GÜRSUL, Fatma YILMAZ KARADAĞ, Mehmet Umut ÇAYIRÖZ, Yeşim KÜREKÇİ, Ayten KADANALI, Zeynep Şule ÇAKAR, Ümit SAVAŞÇI, İlknur ERDEM, and Sabahat ÇAĞAN AKTAŞ
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urinary tract infection ,empirical ,antibiotherapy ,mortality ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: In this study, we aimed to determine the risk factors associated with inadequate empirical antibiotherapy (IEAT) and hospital-related mortality in elderly patients being treated for upper urinary tract infections (UTI). Materials and Methods: This study included individuals aged 65 years and over who were hospitalized after being diagnosed of communityacquired UTI or community-onset healthcare-associated UTI and followed-up in clinics and/or intensive care units (ICU) of 33 hospitals between March and September 2017. Results: A total of 525 patients (48% males; mean age: 76.46±7.93 years) were included in the study. Overall, 68.2% of the patients were hospitalized through the emergency department and 73.9% of patients were followed-up for pyelonephritis. Gram-negative, Gram-positive, and Gram-negative and positive mix growths were determined in 88%, 9.3%, and 2.7% of urine cultures, respectively. Fifty-six (10.7%) of the patients died. In multivariate analysis, the presence of chronic obstructive pulmonary disease [Odds ratio (OR): 2.278], age 85 years and over (OR: 2.816), admission to the ICU (OR: 14.831), and IEAT (OR: 2.364) were independent factors that significantly affected mortality. The presence of a urinary catheter, being followed-up in the ICU, benign prostate hypertrophy, use of antibiotics other than piperacillin-tazobactam and carbapenem were determined as independent factors that significantly affected IEAT (p
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- 2020
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3. Influence of multidrug resistant organisms on the outcome of diabetic foot infection
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Nese Saltoglu, Onder Ergonul, Necla Tulek, Mucahit Yemisen, Ayten Kadanali, Gul Karagoz, Ayse Batirel, Oznur Ak, Cagla Sonmezer, Haluk Eraksoy, Atahan Cagatay, Serkan Surme, Salih A. Nemli, Tuna Demirdal, Omer Coskun, Derya Ozturk, Nurgul Ceran, Filiz Pehlivanoglu, Gonul Sengoz, Turan Aslan, Yasemin Akkoyunlu, Oral Oncul, Hakan Ay, Lutfiye Mulazımoglu, Buket Erturk, Fatma Yilmaz, Gulsen Yoruk, Nuray Uzun, Funda Simsek, Taner Yildirmak, Kadriye Kart Yaşar, Meral Sonmezoglu, Yasar Küçükardali, Nazan Tuna, Oguz Karabay, Nail Ozgunes, and Fatma Sargın
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Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19–90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were re-hospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, CI: 1.82–38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, CI: 1.24–47.96, p = 0.028), and chronic heart failure (OR: 3, CI: 1.01–9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p
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- 2018
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4. Is Diphtheria Booster Vaccination Still Necessary in Turkey?
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Sule Eren CAKAR, Nurgul CERAN, Gül KARAGÖZ, Yasemin TULGAR, Zeynel Abidin DEMİR, and Ayten KADANALI
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Corynebacterium diphtheriae ,epidemiology ,community health ,vaccinology ,public health ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction: Diphtheria is a serious disease that can be prevented by vaccination. The aim of the study was to determine immunity against diphtheria and the necessity of booster doses in the adult population.Materials and Methods: Serum antibody levels and immunity against diphtheria were determined in 568 healthy participants and results were assessed using chi-square test. Diphtheria antibody level was measured by micro-ELISA technique using NovaTec Corynebacterium diphtheriae toxin IgG ELISA kits (Dietzenbach, Germany). Antitoxin level
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- 2018
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5. A Case of Brucellosis due to Brucella melitensis Isolated from Epidural Abscess
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Gül KARAGÖZ, Arzu İRVEM, Şenol ÇOMOĞLU, Sait NADERİ, Şule Eren ÇAKAR, Nilsun ALTUNAL, Ayşe Serra ÖZEL, Sinan ÖZTÜRK, and Ayten KADANALI
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Bacterial infections ,Brucellosis ,treatment ,epidural abcess ,decompression surgery ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Published
- 2017
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6. Evaluation of Tetanus Seropositivity in Healthcare Professionals by Age and Occupational Groups
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Gulsum Cam, Ayse Serra Ozel, and Ayten Kadanali
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Microbiology (medical) ,Infectious Diseases - Abstract
Objective: Our country has limited data on protective antibody levels following primary tetanus immunization. In this study, we planned to evaluate the tetanus antibody seroprevalence of healthcare workers in our hospital according to age and occupational groups. Methods: Tetanus antibody levels were determined by the enzyme-linked immunosorbent assay (ELISA) method. Antibody results were obtained through the hospital operating system, and the tetanus antibody level ≥0.5 IU/mL was considered seropositive. Results: 77.5% of 2082 healthcare workers were seropositive. According to age groups, the highest seropositivity was between 20-29; the lowest seropositivity was found in individuals over 50 years of age and over (66.3%). We determined that tetanus antibody protection decreased with age (p=0.03). There was no difference between tetanus seropositivity according to occupational groups. Conclusion: Antibody levels of tetanus decrease with age, and protection decreases significantly, especially over 50 years of age. It is important to apply a booster dose every ten years following the primary vaccine schedule in tetanus immunization.
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- 2022
7. Acute Disseminated Encephalomyelitis (ADEM) Following Completion of Pneumococcal Meningitis Treatment: A Case Report and Review of the Literature
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Ayşe Serra Ozel, Lutfiye Nilsun Altunal, Zakir Sakci, Ece Asli Yilmaz, Mesut Yilmaz, and Ayten Kadanali
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Microbiology (medical) ,Infectious Diseases ,General Immunology and Microbiology - Published
- 2023
8. The Etiology and Clinical Follow-up of Patients with Acute Viral Hepatitis in an Adult Population: A Prospective Multicenter Study
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Ayse Albayrak, Ozgur Dagli, Ali Ilgın Olut, Serpil Erol, Arzu Altunçekiç Yildirim, Gül Durmuş, Irem Altas, Selma Tosun, Necla Tulek, Ayten Kadanali, Ayse Serra Ozel, and Nurgul Ceran
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Pediatrics ,medicine.medical_specialty ,Multicenter study ,business.industry ,Adult population ,Etiology ,Medicine ,business ,Viral hepatitis ,medicine.disease - Published
- 2021
9. Bir Eğitim Araştırma Hastanesinde Santral Sinir Sistemi Enfeksiyonlarının Yedi Yıllık Değerlendirilmesi
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Mehtap Aydin, Ayten Kadanali, Ayşe Serra Özel, and Lütfiye Nilsun Altunal
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Economics and Econometrics ,business.industry ,Materials Chemistry ,Media Technology ,Medicine ,Forestry ,business - Abstract
Amaç: Santral sinir sistemi enfeksiyonları, acil tanı ve tedavi gerektiren morbidite ve mortalitesi yüksek enfeksiyonlardır. Hastanemizde takip edilen toplum kaynaklı santral sinir sistemi (SSS) enfeksiyonları irdelenerek hasta yönetiminde yardımcı olmak amaçlanmıştır.Yöntem: Ümraniye Eğitim ve Araştırma Hastanesi’nde 2013 ve 2020 yılları arasında SSS enfeksiyonu tanısı konan 56 hasta retrospektif olarak değerlendirildi. Bulgular: Yedi yıl içinde SSS enfeksiyonu tanısı konan 56 hastanın klinik sınıflaması incelendi. En sık akut pürülan menenjit (%51.8), ikinci sırada aseptik menenjit-ensefalit (%35.7) ardından tüberküloz menenjiti (%12.5) olduğu görüldü. Akut pürülan menenjit hastalarının %82.9’unda BOS kültürü sterildi. Bos kültüründe üreme olan hastalarda S. pneumonia (%10.3) ve E. coli (%6.8) saptandı. Aseptik menenjit ve ensefalitte %10 oranında HSV1 PCR pozitifliği mevcuttu. Başvuru esnasında klinik ayırım yapılamadığı için ampirik olarak antiviral ve antibiyotik tedavisi beraber başlanan hasta oranı %21.4 idi.Sonuç: Çalışmamızda başvuru esnasında ensefalit ve menenjit ayrımı yapılamayan hastaların oranı dikkati çekicidir. Ayrıca hastaların çoğunluğunda etkenin izole edilemediği görülmüştür. Genel olarak kullanılan ampirik tedavilerin etken izolasyonunu etkileyebileceği kanaatine varılmıştır. Hastaların yönetiminde SSS enfeksiyonlarına neden olan etkenlerin dağılımının bilinmesi ampirik tedavi seçiminde yol gösterici olmaktadır.
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- 2021
10. Effectiveness of Surgical Prophylaxis Where the Antibiotic Resistance is High
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Esra Nur Karadogan, Ayten Kadanali, and Mehtap Aydin
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Surgical prophylaxis ,medicine.medical_specialty ,Antibiotic resistance ,business.industry ,Medicine ,business ,Intensive care medicine - Published
- 2020
11. A snapshot of geriatric infections in Turkey: ratio of geriatric inpatients in hospitals and evaluation of their infectious diseases: A multicenter point prevalence study
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Ramazan Gözüküçük, Ilyas Dokmetas, Yeşim Taşova, Umit Savasci, Hale Turan Özden, Selma Ateş, Esra Kaya Kılıç, Serhat Birengel, Ali Acar, M Emirhan Işık, Şaban Esen, Fatma Yılmaz Karadağ, Kader Arslan, Rezan Harman, Ahmet Hamidi, Emine Sehmen, Asli Haykir Solay, Ayşe Sağmak Tartar, Sedat Kaygusuz, Funda Kocak, Esmeray Mutlu Yilmaz, Filiz Koc, Ozgur Dagli, Hande Aslaner, Şule Özdemir Armağan, Isil Deniz Aliravci, Serpil Erol, Duru Mıstanoğlu Özatağ, Behice Kurtaran, Canan Agalar, Ilknur Esen Yildiz, Mustafa Dogan, Merve Sefa Sayar, Yeşim Kürekçi, Rıdvan Kara Ali, Ilknur Erdem, Zehra Demirbaş, Yasemin Balkan, Fatime Korkmaz, Funda Bilman, Yesim Uygun Kizmaz, Nur Cancan Gürsul, Hüseyin Şahintürk, Emine Fırat Göktaş, Nefise Oztoprak, Pinar Korkmaz, Hande Aydemir, Aynur Atilla, A İrfan Baran, Nevin Ince, Hülya Kuşoğlu, Sabahat Çağan Aktaş, Ilknur Yavuz, Nilsun Altunal, Abdulkadir Daldal, Ferit Kuşcu, Aslıhan Demirel, Serhat Uysal, Mehmet Ulug, Buket Erturk Sengel, Güliz Evik, Dilara Inan, Gülay Okay, Aslihan Ulu, Nurettin Erben, Selçuk Nazik, A Altunçekiç Yıldırım, Sema Turan, M Reşat Ceylan, Haluk Erdoğan, Hatice Ürgüdücü, Hasan Naz, Kevser Ozdemir, Nirgül Kılıçaslan, Elif Tukenmez Tigen, Süheyla Kömür, Gül Durmuş, Uğur Kostakoğlu, Ayten Kadanali, B Ergüt Sezer, Habibe Tülin Elmaslar Mert, Emel Aslan, Ergenekon Karagoz, Alper Şener, Burcu Ozdemir, Emel Azak, Mevliye Yetik, Kenan Ugurlu, Sema Sarı, A Seza Inal, and OKAY, GÜLAY
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Male ,0301 basic medicine ,Turkey ,healthcare associated infection ,very elderly ,Antibiotics ,Psychological intervention ,Prevalence ,Turkey (republic) ,0302 clinical medicine ,Health care ,antibiotic therapy ,antibiotic agent ,030212 general & internal medicine ,Aged, 80 and over ,Geriatrics ,education.field_of_study ,inappropriate prescribing ,General Medicine ,Hospitals ,Hospitalization ,aged ,hospital patient ,Infectious Diseases ,female ,multicenter study (topic) ,Female ,Infection ,Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Urinary system ,030106 microbiology ,Population ,prevalence ,Infections ,Communicable Diseases ,Article ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,length of stay ,male ,medicine ,Humans ,pneumonia ,lcsh:RC109-216 ,human ,education ,Aged ,Preventive healthcare ,Inpatients ,business.industry ,Antibiotic ,Length of Stay ,major clinical study ,infection ,Emergency medicine ,geriatric disorder ,business - Abstract
Introduction The human population is aging at an astonishing rate. The aim of this study is to capture a situation snapshot revealing the proportion of individuals aged 65 years and over among inpatients in healthcare institutions in Turkey and the prevalence and type of infections in this patient group in order to draw a road map. Materials and Methods Hospitalized patients over 65 years at any of the 62 hospitals in 29 cities across Turkey on February 9, 2017 were included in the study. Web-based SurveyMonkey was used for data recording and evaluation system. Results Of 17,351 patients 5871 (33.8%) were ≥65 years old. The mean age was 75.1 ± 7.2 years; 3075 (52.4%) patients were male. Infection was reason for admission for 1556 (26.5%) patients. Pneumonia was the most common infection. The median length of hospital stay was 5 days (IQR: 2–11 days). The Antibiotic therapy was initiated for 2917 (49.7%) patients at the time of admission, and 23% of the antibiotics prescribed were inappropriate. Healthcare-associated infections developed in 1059 (18%) patients. Urinary catheters were placed in 2388 (40.7%) patients with 7.5% invalid indication. Conclusion This study used real data to reveal the proportion of elderly patients in hospital admissions. The interventions done, infections developed during hospitalization, length of hospital stay, and excessive drug load emphasize the significant impact on health costs and illustrate the importance of preventive medicine in this group of patients.
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- 2020
12. Invisible Threat for Health Care Workers: Injuries Associated With Blood and Body Fluids
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Merve Caglar Ozer, Ayten Kadanali, and Lütfiye Nilsun Altunal
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Microbiology (medical) ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Family medicine ,Health care ,Medicine ,business - Published
- 2020
13. Anthrax: Unforgettable Disease in the Modern Era
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Ayten Kadanali and Ayse Serra Ozel
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Microbiology (medical) ,Infectious Diseases ,business.industry ,Medicine ,Disease ,Ancient history ,business - Published
- 2020
14. Foot self-care in diabetes mellitus: Evaluation of patient awareness
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Serpil Erol, Yasemin Akkoyunlu, Fatma Yılmaz Karadağ, Meliha Meriç Koç, Seniha Senbayrak, Yasar Kucukardali, Ayten Kadanali, Oznur Ak, Duru Mıstanoğlu Özatağ, Arzu Altunçekiç Yildirim, Senol Comoglu, Nese Saltoglu, Gule Aydin, Gulsen Yoruk, AKKOYUNLU, YASEMİN, Yılmaz Karadağ, F., Saltoğlu, N., Ak, Ö., Çınar Aydın, G., Şenbayrak, S., Erol, S., Altunçekiç Yıldırım, A., and Yeditepe Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Disease duration ,030209 endocrinology & metabolism ,Evaluation of patient awareness-, PRIMARY CARE DIABETES, cilt.13, ss.515-520, 2019 [Karadag F. Y. , Saltoglu N., Ak O., Aydin G. C. , Senbayrak S., Erol S., Ozatag D. M. , Kadanali A., Kucukardali Y., Comoglu S., et al., -Foot self-care in diabetes mellitus] ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,Foot disease ,Aged ,Retrospective Studies ,Aged, 80 and over ,Foot self-care ,Nutrition and Dietetics ,business.industry ,Diabetes ,Diabetic foot care ,Awareness ,Middle Aged ,medicine.disease ,Diabetic Foot ,Self Care ,Cross-Sectional Studies ,Amputation ,Physical therapy ,Self care ,Female ,Family Practice ,business ,Patient awareness ,Foot (unit) ,Foot care - Abstract
Aims: To assess diabetic patients’ knowledge and practices regarding foot care. Methods: This study was conducted as a cross-sectional study in 1030 patients between November 2017 and February 2018.The descriptive survey instrument was developed by the investigators. Survey content and format were based on prior surveys and guidelines. The survey sought socio-demographic characteristics of the patients and the level of knowledge about diabetic foot care practice. Results: 29.5% of patients had bad foot care, 49.6% of patients had moderate foot care and 20.8% of patients had good foot care. There were no significant differences between patient groups in regard to age, gender, foot infection history and having undergone amputation surgery. We found that patients who good at foot care had higher education status (p < 0.001), were more likely live in a city (p < 0.001), had higher income (p < 0.001), had been trained about foot care (p < 0.001) and were more likely to have type I DM (p = 0.015). Disease duration was longer in those who had good foot care compared to the other groups (p = 0.010). Conclusions: The mean knowledge and practice scores of our patients were moderate, indicating that much is to be done for the education of patients on this matter. We also found that knowledge about the importance of this practice, education status and disease duration had significant influence on the practice of foot-care in patients with DM. © 2019 Primary Care Diabetes Europe
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- 2019
15. SANTRAL SİNİR SİSTEMİ İNFEKSİYONU TANILI 98 OLGUNUN KLİNİK ÖZELLİKLERİ
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Lütfiye Nilsun ALTUNAL, Servet ÖZTÜRK, Mehtap AYDIN, Ayşe Serra ÖZEL, and Ayten KADANALI
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Acute bacterial meningitis,aseptic meningitis,brain abscess,encephalitis,fungal meningitis,tuberculous meningitis ,Mikrobiyoloji ,General Engineering ,Akut bakteriyel menenjit,aseptik menenjit,beyin absesi,ensefalit,fungal menenjit,tüberküloz menenjiti ,Microbiology - Abstract
Central nervous system (CNS) infections are inflammation of the brain meninges and parenchyma that can develop with many different microorganisms. Early diagnosis and effective treatment are important in the survival of patients. In our study, it was aimed to examine the clinical features of the patients followed up with the diagnosis of CNS infection.The data of 98 patients diagnosed with community acquired CNS infection in Ümraniye Training and Research Hospital and Fatih Sultan Mehmet Training and Research Hospital between February 2013 and December 2020 were evaluated retrospectively.Of the 98 patients diagnosed with CNS infection, 62 % (61) were male, mean age was 53.5±7.4 years. According to the classification, 43 (44 %) of the patients were acute bacterial meningitis, 38 (39 %) aseptic meningitis encephalitis, eight (8 %) tuberculous meningitis, five (5 %) brain abscess, and four (4 %) fungal meningitis. A predisposing factor was observed in 80 % of patients with brain abscess, 50 % of patients with fungal meningitis, and 31% of patients diagnosed with acute bacterial meningitis. Streptococcus pneumoniae (14 %), Escherichia coli (7 %) and Listeria monocytogenes (7 %) were most commonly grown in the cerebrospinal fluid culture of the acute bacterial meningitis patient group. In the aseptic meningitis encephalitis group, the most frequently isolated agent was VZV (18 %), followed by HSV type 1 (5 %) and HSV type 2 (5 %). Cryptococcus neoformans was isolated in all patients followed up with the diagnosis of fungal meningitis. Complications developed 50 % of the patients followed up with tuberculous meningitis.In our study, S.pneumoniae was most common in patients with acute bacterial meningitis and VZV was most common in patients with aseptic meningitis-encephalitis. Our findings will guide the management of patients with CNS infection., Santral sinir sistemi (SSS) infeksiyonları farklı birçok mikroorganizma ile gelişebilen, beyin meninks ve parankiminin enflamasyonu ile karakterize hastalıklardır. Hastaların sağ kalımında erken tanı ve etkin tedavi uygulanması önem arz etmektedir. Çalışmamızda SSS infeksiyonu tanısıyla takip edilen hastaların klinik özelliklerinin irdelenmesi amaçlanmıştır.Ümraniye Eğitim ve Araştırma Hastanesi’nde ve Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi’nde Şubat 2013 ve Aralık 2020 yılları arasında toplum kökenli SSS infeksiyonu tanısı konan 98 hastanın verileri retrospektif olarak değerlendirilmiştir.SSS infeksiyonu tanısı konan 98 hastanın % 62’sinin (61) erkek, yaş ortalamasının 53,5±7,4 olduğu görülmüştür. Yapılan sınıflamaya göre hastaların 43’ü (% 44) akut bakteriyel menenjit, 38’i (% 39) aseptik menenjit ensefalit, sekizi (% 8) tüberküloz menenjiti, beşi (% 5) beyin absesi, dördü (% 4) fungal menenjit tanısı almıştır. Beyin absesi tanılı hastaların % 80’inde, fungal menenjit tanılı hastaların % 50’sinde, akut bakteriyel menenjit tanısı konan hastaların % 31’inde predispozan bir faktör olduğu görülmüştür. Akut bakteriyel menenjit hasta grubunun beyin omurilik sıvısı kültüründe en sık Streptococcus pneumoniae (% 14), Escherichia coli (% 7) ve Listeria monocytogenes (% 7) üremiştir. Aseptik menenjit ensefalit grubunda ise en sık belirlenen etken VZV (% 18) ardından HSV tip 1 (% 5) ve HSV tip 2 (% 5) olmuştur. Fungal menenjit tanısı ile takip edilen hastaların hepsinde Cryptococcus neoformans izole edilmiştir. Tüberküloz menenjiti ile takip edilen hastaların % 50’sinde komplikasyon gelişmiştir.Çalışmamızda, akut bakteriyel menenjit hastalarında en sık S.pneumoniae, aseptik menenjit-ensefalit hastalarında da en sık VZV izole edilmiştir. Bulgularımız SSS infeksiyonu tanılı hastaların yönetiminde yol gösterici olacaktır.
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- 2021
16. Brucellosis in pregnancy: results of multicenter ID-IRI study
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Seval Bilgic-Atli, Hakan Erdem, Ayşe Erbay, Nicholas J. Beeching, Ergin Ayaslioglu, Recep Tekin, Mile Bosilkovski, S. Sahin, Mehmet Ulug, Tuna Demirdal, Serap Ural, Alper Şener, Tansu Yamazhan, Asuman Inan, Emsal Aydin, Selma Tosun, Asli Haykir-Solay, Serda Gulsun, Selçuk Kaya, Nazif Elaldi, Pınar Ergen, Abdullah Umut Pekok, Elif Sahin-Horasan, Murat Muhcu, Mustafa Kasim Karahocagil, Mahmut Sunnetcioglu, Ayten Kadanali, Yakup Cag, Ali Avci, Şafak Kaya, Kırıkkale Üniversitesi, and [Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, Hakan] Gulhane Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, Serda -- Kaya, Safak -- Bilgic-Atli, Seval] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa K.] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Pekok, Abdullah U.] Pendik Med Pk Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ulug, Mehmet] Private Umut Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Bosilkovski, Mile] Skopje Med Fac, Dept Infect Dis & Febrile Condit, Skopje, Macedonia -- [Haykir-Solay, Asli] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Demirdal, Tuna -- Ural, Serap] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Aydin, Emsal] Kafkas Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kars, Turkey -- [Yamazhan, Tansu] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Muhcu, Murat] GATA Haydarpasa Training Hosp, Dept Obstet & Gynecol, Istanbul, Turkey -- [Ayaslioglu, Ergin] Kirikkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kirikkale, Turkey -- [Erbay, Ayse] Bozok Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Yozgat, Turkey -- [Ergen, Pinar] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Sahin, Suzan] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Avci, Ali] Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Urol, Izmir, Turkey -- [Cag, Yakup] Turkish Hlth Sci Univ, Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Beeching, Nicholas J.] Univ Liverpool Liverpool Sch Trop Med, Clin Sci, Liverpool, Merseyside, England
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Adult ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Adolescent ,Fever ,Turkey ,030106 microbiology ,Bacteremia ,Oligohydramnios ,Abortion ,Brucellosis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Abortus ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,Retrospective Studies ,Intrauterine fetal demise ,Obstetrics ,business.industry ,Infant, Newborn ,General Medicine ,Middle Aged ,medicine.disease ,Brucella ,Abortion, Spontaneous ,Low birth weight ,Cross-Sectional Studies ,Infectious Diseases ,Risk factors ,Splenomegaly ,Cohort ,Vomiting ,Female ,medicine.symptom ,business - Abstract
WOS: 000471726700008, PubMed ID: 30989418, Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
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- 2019
17. The factors affecting inadequate empirical antimicrobial therapy and clinical course in upper urinary tract infections of the elderly patients
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Derya Ozturk Engin, Pinar Korkmaz, Rezan Harman, Behice Kurtaran, Asuman Inan, Kenan Uğurlu, Mehmet Umut Çayiröz, Umit Savasci, Aslıhan Demirel, Hale Turan Özden, Aslıhan Burcu Yikilgan, Yeşim Kürekçi, Yesim Uygun Kizmaz, Ayten Kadanali, Zeynep Sule Cakar, Alper Şener, Pınar Firat, Fulya Bayindir Bilman, Burcu Ozdemir, Şule Özdemir Armağan, Buket Erturk Sengel, Nur Cancan Gürsul, Gülay Okay, Mehmet Emirhan Işık, Sabahat Çağan Aktaş, Duru Mistanoğlu Özatağ, Canan Ağalar, Fatma Kaçar, Hülya Kuşoğlu, Ayşe But, Ilknur Erdem, Hasan Naz, Özgür Dağli, Gül Durmuş, Fatma Yilmaz Karadağ, Büşra Ergüt Sezer, Ferit Kuşcu, Selma Ateş, Elif Tukenmez Tigen, Ilyas Dokmetas, Elif Doyuk Kartal, Aziz Ahmad Hamidi, and Funda Kocak
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Microbiology (medical) ,medicine.medical_specialty ,Infectious Diseases ,General Immunology and Microbiology ,Multicenter study ,business.industry ,Internal medicine ,medicine ,Clinical course ,Antimicrobial ,business ,Upper urinary tract - Published
- 2020
18. Effect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies
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Ercan Yenilmez, Rıza Aytaç Çetinkaya, Ismail Necati Hakyemez, Cigdem Ataman-Hatipoglu, Faruk Karakeçili, Onur Toka, Nazlim Aktug-Demir, Necla Tulek, Gulsen Yoruk, Gunay Tuncer-Ertem, Sengul Ucer, Rezan Harman, Fatma Sirmatel, Pinar Korkmaz, Ayten Kadanali, Güliz Evik, Esma Yüksel, Ayfer Imre, Figen Sarigul, Meliha Meric-Koc, Güle Çınar, Onur Ural, Ali Kaya, Kaya Suer, Muge Ozguler, Sua Sumer, Zehra Bestepe-Dursun, Duru Mistanoglu-Ozatag, Neşe Demirtürk, Senol Comoglu, İlhami Çelik, Ayse Batirel, Özgür Günal, Nese Saltoglu, Emel Yilmaz, Hacer Deniz Ozkaya, Hacettepe Universitesi, Tip Fakultesi, Biyoistatistik Anabilim Dali, Ankara, Turkiye, HAKYEMEZ, İSMAİL NECATİ, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
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Microbiology (medical) ,Oncology ,medicine.medical_specialty ,Tenofovir ,business.industry ,KORKMAZ P., Demirturk N., Batirel A., Tulek N., Ozguler M., Harman R., Cinar G., TOKA O., Yoruk G., Ataman-Hatipoglu C., et al., -Effect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies-, KLIMIK JOURNAL, cilt.32, ss.265-274, 2019 ,Entecavir ,tenofovir ,Virological response ,Infectious Diseases ,Fatty liver ,Internal medicine ,Medicine ,business ,entecavir ,medicine.drug - Abstract
Toka, Onur/0000-0002-4025-4537; Yoruk, Gulsen/0000-0002-0357-5884; Cinar, Gule/0000-0002-7635-8848; Hakyemez, Ismail Necati/0000-0001-6133-9604; Tulek, Necla/0000-0002-3952-4982 WOS:000511173500009 Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48'h week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results.
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- 2019
19. Seasonal influenza vaccination coverage: a multicenter cross-sectional study among healthcare workers
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Tansu Yamazhan, Melike Öğütmen, Sinan Ozturk, Serpil Erol, Zehra Karacaer, Meltem Taşbakan, Özlem Mete, Ergenekon Karagoz, Ilknur Esen Yildiz, Fatma Unlu, Handan Alay, Deniz Akyol, Nefise Oztoprak, Hülya Özkan Özdemir, Ayhanım Tümtürk, Merve Sefa Sayar, Rıza Aytaç Çetinkaya, Mustafa Doğan, Ayten Kadanali, Arzu Altunçekiç Yildirim, Suna Seçil Öztürk Deniz, Kenan Ugurlu, Selda Sayin, Zehra Çağla Karakoç, Ozlem Senaydin, Büşra Ergüt Sezer, Nurgul Ceran, Fernaz Yildiz, Gül Durmuş, Duygu Mert, Selma Tosun, Pınar Ergen, Emre Güven, Abdulkadir Daldal, Ayse Batirel, Mustafa Uğuz, Ozgur Dagli, Osman Ekinci, Yasemin Balkan, Şirin Menekşe, İbrahim Mungan, Yesim Uygun Kizmaz, Duru Mistanoglu Ozatay, Uğur Kostakoğlu, Nuran Sari, Cumhur Artuk, Fazilet Duygu, Ercan Yenilmez, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Zehra Çağla Karakoç / 0000-0002-1618-740X, Karakoç, Zehra Çağla, Zehra Çağla Karakoç / AAR-5295-2020, and Zehra Çağla Karakoç / 54889818300
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Seasonal Influenza Vaccination ,Cross-sectional study ,education ,Tertiary care ,Seasonal influenza ,Health Care Sciences and Services ,Environmental health ,Health care ,Medicine ,Tutumlar ,Sağlık Çalışanları ,Sağlık Bilimleri ve Hizmetleri ,Vaccination rate ,seasonal influenza vaccination,healthcare workers,attitudes ,business.industry ,Healthcare Workers ,virus diseases ,General Medicine ,Mevsimsel Inluenza Aşısı ,Vaccination ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Vaccination coverage ,Attitudes ,business ,mevsimsel inluenza aşısı,sağlık çalışanları,tutumlar - Abstract
Aim: The aim of this study is to evaluate the attitudes of healthcare workers against seasonal influenza vaccine and the reasons for vaccine avoidance. Materials and Methods: This national survey was conducted from April 1st to June 30th in 2017. The study was carried out among health care workers working in primary, secondary and tertiary care settings. A total of 12 questions were sent to 5046 health care professionals from 55 different cities who agreed to participate in the survey.Results: 7% of the participants stated that they get vaccinated regularly every year. 65.8% of the participants stated that they don’t get vaccinated at all. The most important reason for those who did not receive influenza vaccination was their disbelief in the necessity of the vaccination (51.9%). The most common reason for the seasonal influenza vaccination was the prevention of influenza infection (56.7%).Conclusion: The results of the study showed that HCWs influenza vaccination rates are very low. Doctors have been found to have slightly better rates than other HCWs. The high level of education and the increase in professional experience had a positive effect on the vaccination rate. It is important to know the HCWs attitudes and behaviors towards the vaccination to increase the rates., Amaç: İnfluenza tüm dünyada önemli ölçüde morbidite, mortalite ve maliyet yükünden sorumludur. Sağlık çalışanları (HCP) mesleksel bulaş açısından risk altındadırlar. Bu çalışmada sağlık çalışanlarının mevsimsel influenza aşısına karşı tutumlarının ve aşıdan kaçınma nedenlerinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Bu çok merkezli ulusal anket çalışması 1 Nisan-30 Haziran 2017 tarihleri arasında gerçekleştirildi. Ankete katılmayı kabul eden 55 şehirden toplam 5046 HCP uzaktan katılım yoluyla cevaplamaları için toplam 12 sorudan oluşan bir anket gönderildi.Bulgular: Çalışmaya katılanların %7’si her yıl düzenli olarak aşı yaptırdığını belirtti. Hiç yaptırmıyorum diyenlerin oranı %65,8 idi. İnfluenza aşışını yaptırmayanların en önemli nedeni grip aşısının gerekliliğine inanmama idi (%51,9). Mevsimsel grip aşısı yaptıranların en önemli gerekçesi grip infeksiyonundan korunma (%56,7) idi.Sonuç: Sonuçlarımız, tüm HCP influenza aşılama oranlarının çok düşük olduğunu göstermiştir. Doktorların diğer HCP’lerden biraz daha iyi oranlara sahip olduğunu görülmüştür. Eğitim düzeyinin yüksek olması ve mesleki tecrübenin artması aşılama oranını olumlu yönde etkilemiştir. Sağlık çalışanlarının aşılanma oranlarının artırılabilmesi için öncelikle aşı konusundaki tutum ve davranışlarının bilinmesi gerekir.
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- 2019
20. A Case of DRESS Syndrome Presented With Elevated Procalcitonin Levels
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Sinan Ozturk, Lütfiye Nilsun Altunal, Senol Comoglu, Ayten Kadanali, Zeynep Sule Cakar, Fidan Dogan, Pinar Onguru, Gül Karagöz, and Ayse Serra Ozel
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Microbiology (medical) ,medicine.medical_specialty ,Infectious Diseases ,business.industry ,Internal medicine ,medicine ,business ,Gastroenterology ,Procalcitonin - Published
- 2019
21. Daptomycin in the Treatment of Diabetic Foot Infections without Osteomyelitis; A Multicenter Study
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Hüsnü Pullukçu, Gül Karagöz, Meltem Taşbakan, Saygın Nayman Alpat, Oğuz Reşat Sipahi, Anıl Murat Öztürk, Zülal Özkurt, Behice Kurtaran, Bilgin Arda, Tansu Yamazhan, Gökhan Karaahmetoğlu, Serhat Uysal, Özlem Güzel Tunçcan, Süheyla Kömür, Nur Yapar, Ayten Kadanali, Alper Şener, Neşe Demirtürk, and Nefise Öztoprak Çuvalci
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Staphylococcus aureus ,medicine.medical_specialty ,Diabetic foot infections ,business.industry ,Osteomyelitis ,lcsh:QR1-502 ,medicine.disease ,lcsh:Microbiology ,lcsh:Infectious and parasitic diseases ,Surgery ,Diabetic foot ,Daptomycin ,Multicenter study ,medicine ,lcsh:RC109-216 ,business ,medicine.drug - Abstract
Introduction: Although diabetic foot infections are polymicrobial, gram-positive microorganisms comprise the majority. Daptomycin is a novel agent in treating infections due to multidrug-resistant gram-positive pathogens. In this multicenter study, the outcomes of the daptomycin treatment were evaluated retrospectively in the treatment of diabetic foot infectious without osteomyelitis. Materials and Methods: Patients with diabetic foot infection without osteomyelitis and who received daptomycin treatment were included into the study. Sociodemographic characteristics of the patients, risk factors for methicillin resistant Staphylococcus aureus (MRSA), antimicrobial treatment, and the data of microbiological and clinical outcomes of the cases were registered in a standard form by eleven centers. Clinical success was defined as a combination of end-of-treatment laboratory parameters, clinical and microbiological responses. Results: A total of 46 patients (30 males, 16 females) were clinically evaluated for the outcome of daptomycin therapy. Mean age was 61.09 ± 11.82 years (31-81) and mean diabetes duration was 13 ± 8.2 years. The number of mild, moderate and severe infections identified according to the infection scoring system of the Infectious Diseases Society of America (IDSA) were 12 (26.1%), 25 (54.3%), and 9 (19.6%) respectively. Duration of daptomycin therapy was 17.5 ± 9.3 days and overall daptomycin success rate was 82.6% (n= 38). Two patients developed side effects. Conclusion: The clinical success rate of this study which assessed the efficacy of daptomycin in diabetic foot infections was 82.6%. Daptomycin can be safely used even in severe cases having had no success with previous antibiotic therapy.
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- 2017
22. A Case of Increased Creatin Kinase Level Caused by Daptomycin
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Fidan Doğan, Ayten Kadanali, Ayşe Serra Özel, Şenol Çomoğlu, Lütfiye Nilsun Altunal, Zeynep Sule Cakar, Gül Karagöz, Sinan Ozturk, and Mehmet Fatih Bektaşoğlu
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business.industry ,Kinase ,Medicine ,Pharmacology ,Daptomycin ,business ,medicine.drug - Published
- 2019
23. Awareness of hepatitis B virus reactivation among physicians administering immunosuppressive treatment and related clinical practices
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Sinan Ozturk, Onur Toka, Sabahat Ceken, Kiymet Gundogdu, Suda Tekin, Rıza Aytaç Çetinkaya, Nese Saltoglu, Gülden Ersöz, Ismail Necati Hakyemez, Sukran Kose, Selmin Dirgen Çaylak, Ziya Kuruüzüm, Nesrin Türker, Huseyin Kaya Suer, Zerrin Asci, Mehmet Reşat Ceylan, Alper Şener, Sua Sumer, Onur Ural, Ercan Yenilmez, Neşe Demirtürk, Aysel Kocagul Celikbas, Dilara Inan, Oya Özlem Eren Kutsoylu, Selcan Arslan Ozel, Asli Haykir Solay, Celal Ayaz, Özgür Günal, Eyup Arslan, İrem Akdemir Kalkan, Bilgehan Aygen, Ayse Batirel, Sıla Akhan, Mehtap Aydin, Bahar Ormen, Zuhal Yesilbag, Ergenekon Karagoz, Murat Sayan, Necla Tulek, Hacer Deniz Ozkaya, Gule Aydin, Ali Acar, Pinar Korkmaz, Fatma Yılmaz Karadağ, Vuslat Ecem Gunes Altiparmak, Ayten Kadanali, Nazlim Aktug Demir, Meliha Çağla Sönmezer, Gulsen Yoruk, Fatma Sirmatel, Koruk, Süda Tekin, Korkmaz, Pınar, Demirtürk, Neşe, Aydın, Güle, Çeken, Sabahat, Aygen, Bilgehan, Toka, Onur, Gündoğdu, Kıymet, Kocagül-Çelikbaş, Aysel, İnan, Dilara, Kuruüzüm, Ziya, Eren-Kutsoylu, Oya Özlem, Batırel, Ayşe, Sırmatel, Fatma, Ersöz, Gülden, Hakyemez, İsmail Necati, Aşçı, Zerrin, Yeşilbağ Zuhal, Sönmezer, Meliha Çağla, Tülek, Necla, Örmen, Bahar, Yılmaz-Karadağ, Fatma, Yörük, Gülşen, Türker, Nesrin, Özkaya, Hacer Deniz, Akdemir-Kalkan, İrem, Süer, Hüseyin Kaya, Saltoğlu, Neşe, Şener, Alper, Yenilmez, Ercan, Çetinkaya, Rıza Aytaç, Arslan-Özel, Selcan, Ayaz, Celal, Karagöz, Ergenekon, Aydın, Mehtap, Acar, Ali, Arslan, Eyüp, Ceylan, Mehmet Reşat, Aktuğ-Demir, Nazlım, Dirgen-Çaylak, Selmin, Günal, Özgür, Haykır-Solay, Aslı, Öztürk, Sinan, Ural, Onur, Sümer, Süa, Kadanalı, Ayten, Güneş-Altıparmak, Vuslat Ecem, Akhan, Sıla, Sayan, Murat, Köse, Şükran, Koç University Hospital, Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Demir, Nazlım Aktuğ, Sümer, Şua, MÜ, HAKYEMEZ, İSMAİL NECATİ, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
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Microbiology (medical) ,Hepatitis B virus ,Immunosuppressive treatment ,reactivation ,immunosuppression ,business.industry ,virus diseases ,Medicine, general and internal ,Microbiology ,İmmünosüpresyon ,Reaktivasyon ,medicine.disease_cause ,Reactivation ,Hepatitis B ,digestive system diseases ,Infectious Diseases ,Immunology ,Medicine ,KORKMAZ P., Demirturk N., Aydin G., Ceken S., AYGEN B., TOKA O., GÜNDOĞDU K., Kocagul-Celikbas A., İNAN D., KURUÜZÜM Z., et al., -Awareness of Hepatitis B Virus Reactivation Among Physicians Administering Immunosuppressive Treatment and Related Clinical Practices-, KLIMIK JOURNAL, cilt.32, ss.146-153, 2019 ,business ,Immunosuppression - Abstract
Objective: this study aimed to evaluate the awareness and knowledge levels of all physicians administering immunosuppressive treatment concerning hepatitis B virus (HBV) reactivation, and draw attention to the importance of the subject through evaluation. Methods: the study was carried out by infectious diseases and clinical microbiology specialists in 37 health centers, and it was performed in Turkey between January and March 2017. All specialists providing a written consent and working in the departments of Medical Oncology, Hematology, Dermatology and Venereology, Physical Medicine and Rehabilitation, and Rheumatology of each study center were included in the study. Results: a total of 430 physicians participated in the study. Their mean age was 39.87 +/- 7.42 years, and 47.9% of them were males. During their career, 39.3% of these physicians had encountered patients developing HBV reactivation while receiving immunosuppressive treatment. The rate of encountering patients who died due to HBV reactivation was 6.5%. 97% of physicians who participated, considered the risk of HBV reactivation to be important. 70.2% of physicians stated that guidelines related to HBV reactivation and antiviral treatment for these patients were discussed in the congresses they participated, regarding their specialties. The rate of performing hepatitis screening among physicians whose patients developed HBV reactivation was statistically significantly higher than those physicians who had no patients with HBV reactivation (p, NA
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- 2019
24. Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study
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Ayşe Seza Inal, Kaan Meric, Filiz Pehlivanoglu, Meltem Avci, Oğuz Reşat Sipahi, Asuman Inan, Derya Ozturk-Engin, Hanefi Cem Gul, Selçuk Kaya, Esmeray Mutlu-Yilmaz, Selma Tosun, Ayten Kadanali, Sibel Bolukcu, Tumer Guven, Elif Sahin-Horasan, Emel Yilmaz, Abdullah Umut Pekok, Fatma Sirmatel, Canan Agalar, Celal Ayaz, Mustafa Kasim Karahocagil, Ayse Batirel, Hasan Karsen, Secil Deniz, Hakan Erdem, Asli Haykir-Solay, Nefise Oztoprak, Asim Ulcay, Gonul Sengoz, Mahmut Sunnetcioglu, Ayhan Akbulut, Nazif Elaldi, Selma Ates-Guler, Mehmet Ulug, Recep Tekin, Affan Denk, Yasemin Cag, Mustafa Namiduru, Emine Parlak, Sukran Kose, Rodrigo Hasbun, Mustafa Kemal Çelen, Tuna Demirdal, Seniha Senbayrak, Huseyin Turgut, Kadriye Kart Yaşar, Ali İrfan Baran, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Yılmaz, Emel, Çukurova Üniversitesi, [Erdem, Hakan] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Senbayrak, Seniha -- Deniz, Secil -- Ozturk-Engin, Derya -- Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Meric, Kaan] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Batirel, Ayse] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Karahocagil, Mustafa Kasim -- Baran, Ali Irfan -- Sunnetcioglu, Mahmut] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Hasbun, Rodrigo] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Infect Dis, Houston, TX 77030 USA -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Karsen, Hasan] Harran Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, Turkey -- [Kaya, Seluk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Inal, Ayse Seza] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Pekok, Abdullah Umut] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Celen, Mustafa Kemal -- Tekin, Recep -- Ayaz, Celal] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Ulug, Mehmet] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Demirdal, Tuna] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Namiduru, Mustafa] Gaziantep Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Guven, Tumer] Ankara Atatrk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Parlak, Emine] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Bolukcu, Sibel -- Sipahi, Oguz Resat] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Avci, Meltem -- Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Emel] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Ates-Guler, Selma] Sutcu Imam Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kahramanmaras, Turkey -- [Mutlu-Yilmaz, Esmeray] Samsun Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Akbulut, Ayhan -- Denk, Affan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Oztoprak, Nefise] Antalya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey -- [Cag, Yasemin] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Turgut, Huseyin] Pamukkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Denizli, Turkey -- [Gul, Hanefi Cem -- Ulcay, Asim] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Haykir-Solay, Asli] Igdir State Hosp, Dept Infect Dis & Clin Microbiol, Igdir, Turkey -- [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, ayaz, celal -- 0000-0002-9060-1090, and Kart Yasar, Kadriye -- 0000-0003-2963-4894
- Subjects
Nervous-system brucellosis ,Male ,Pathology ,Turkey ,Glucose blood level ,0302 clinical medicine ,middle aged ,nuclear magnetic resonance imaging ,granuloma ,brain edema ,protein cerebrospinal fluid level ,neuroimaging ,adult ,General Medicine ,Case Report ,Agglutination Tests ,Zoonosis ,Nuclear magnetic resonance imaging ,aged ,Protein cerebrospinal fluid level ,Diagnostic imaging ,brain infection ,Human ,Microbiology (medical) ,medicine.medical_specialty ,diagnostic imaging ,030106 microbiology ,Major clinical study ,Microbiology ,Article ,03 medical and health sciences ,x-ray computed tomography ,Humans ,human ,lymphocyte count ,Polyradiculopathy ,radiculopathy ,Aged ,X-ray computed tomography ,microbiology ,medicine.disease ,major clinical study ,Brucella ,glucose blood level ,Glucose ,Arachnoiditis ,cerebrospinal fluid level ,Brain edema ,Lymphocyte count ,polyneuropathy ,030217 neurology & neurosurgery ,0301 basic medicine ,Physiology ,Turkey (republic) ,computer assisted tomography ,Cerebrospinal fluid ,Diagnosis ,Prevalence ,glucose ,Radiculopathy ,brain disease ,CSF albumin ,cranial nerve ,Cranial nerve ,Brain Diseases ,Granuloma ,Cerebrospinal fluid level ,medicine.diagnostic_test ,White matter ,spinal root ,Brain infection ,Middle Aged ,Magnetic Resonance Imaging ,brain abscess ,Brain abscess ,female ,Infectious Diseases ,brucellosis ,young adult ,Female ,Neurobrucellosis ,hydrocephalus ,white matter ,Polyneuropathy ,Hydrocephalus ,Adult ,Adolescent ,Brain Diseases/diagnostic imaging/*pathology ,Brucella/physiology ,Brucellosis/diagnostic imaging/*epidemiology/microbiology/pathology ,Neuroimaging ,Tomography, X-Ray Computed ,Turkey/epidemiology ,Young Adult ,Brucellosis ,Cerebral edema ,Computer assisted tomography ,medicine ,controlled study ,Meningitis ,Brain disease ,Inflammation ,business.industry ,Protein ,Magnetic resonance imaging ,Computerized tomography ,arachnoiditis ,physiology ,DiagnosisInflammation ,pathology ,Involvement ,protein ,Spinal root ,business ,Controlled study - Abstract
WOS: 000388827200008, PubMed ID: 27138335, Objective Neuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes. Methods Istanbul-3 study evaluated 263 adult patients with CNS brucellosis from 26 referral centers and reviewed their 242 magnetic resonance imaging (MRI) and 226 computerized tomography (CT) scans of the brain. Results A normal CT or MRI scan was seen in 143 of 263 patients (54.3 %). Abnormal imaging findings were grouped into the following four categories: (a) inflammatory findings: leptomeningeal involvements (44), basal meningeal enhancements (30), cranial nerve involvements (14), spinal nerve roots enhancement (8), brain abscesses (7), granulomas (6), and arachnoiditis (4). (b) White-matter involvement: white-matter involvement (32) with or without demyelinating lesions (7). (c) Vascular involvement: vascular involvement (42) mostly with chronic cerebral ischemic changes (37). (d) Hydrocephalus/cerebral edema: hydrocephalus (20) and brain edema (40). On multivariate logistic regression analysis duration of symptoms since the onset (OR 1.007; 95 % CI 1-28, p = 0.01), polyneuropathy and radiculopathy (OR 5.4; 95 % CI 1.002-1.013, p = 0.044), cerebrospinal fluid (CSF)/serum glucose rate (OR 0.001; 95 % CI 000-0.067, p = 0.001), and CSF protein (OR 2.5; 95 % CI 2.32.7, p = 0.0001) were associated with diffuse inflammation. Conclusions In this study, 45 % of neurobrucellosis patients had abnormal neuroimaging findings. The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses.
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- 2016
25. Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report
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Caner Arslan, Turan Aslan, Oral Oncul, Onder Kilicoglu, Irfan Sencan, Selcuk Baktiroglu, Ilhan Satman, Selda Celik, Lutfiye Mulazimoglu, Zeynep Osar-Siva, Ayten Kadanali, Abdullah Kemal Tuygun, Ali Oznur, Muzaffer Altindas, Ahmet Cinar Yasti, Özge Turhan, Bulent Ertugrul, Temel Yilmaz, Aynur Engin, Haluk Eraksoy, Serdar Güler, Onder Ergonul, Ozlem Tanriover, Nese Saltoglu, Şamil Aktaş, Hasan Tüzün, and Nermin Olgun
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Microbiology (medical) ,medicine.medical_specialty ,business.industry ,Turkish ,030209 endocrinology & metabolism ,medicine.disease ,Diabetic foot ,language.human_language ,Surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Diagnosis treatment ,Internal medicine ,language ,Medicine ,business ,Turkish Consensus Report-, KLIMIK JOURNAL, cilt.28, ss.2-34, 2015 [SALTOĞLU N., Kilicoglu O., Baktiroglu S., Osar-Siva Z., AKTAŞ Ş., Altindas M., Arslan C., Aslan T., Celik S., Engin A., et al., -Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections] - Abstract
Study Group for Diabetic Foot Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases has called for collaboration of the relevant specialist societies and the Ministry of Health to issue a national consensus report on the diagnosis, treatment and prevention of diabetic foot (DF) wounds and diabetic foot infections (DFIs) in Turkey. In the periodical meetings of the assigned representatives from all the parties, various questions as to pathogenesis, microbiology, assessment and grading, treatment, prevention and control of diabetic foot were identified. Upon reviewing related literature and international guidelines, these questions were provided with consensus answers. Several of the answers provided in the report are listed below: [1] Although there are many reasons for the development of DF wounds, the main reason is the combined effect of diabetes-related vascular disease and neuropathy. [2] Aerobic Gram- positive cocci are mostly responsible for superficial DFIs in patients with cellulitis and no history of antibiotic use. [3] Pseudomonas aeruginosa is one of the commonly encountered agents when between the toes of the patient are moist. [4] When the other potential reasons are eliminated, DFIs should be considered in presence of at least two of the classical signs of inflammation including redness, warmth, swelling, tenderness, and pain, or purulent discharge in the foot lesion. [5] Infections are classified into mild, moderate, or severe groups according to some criteria such as the depth and width of the wounds, and the presence of systemic findings of infection. [6] PEDIS system should be preferred as a classification system for its high predictive value in diabetes-related foot complications. [7] Culture samples from the DF wound should only be obtained when infection is clinically considered and, where possible, before starting antibiotic treatment. [8] Inflammatory biomarkers such as leukocyte count, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin may be useful in distinguishing between colonization with infection. [9] Magnetic resonance imaging is a sensitive and specific method in patients unresponsive to treatment when osteomyelitis and deep soft tissue abscesses are considered. [10] The gold standard in the diagnosis of osteomyelitis is histopathological examination. [11] To provide wound healing and to save the limb, removal of dead and infected tissue with urgent and aggressive debridement, appropriate antibiotic therapy, metabolic control, and off-loading of pressure, the diagnosis and proper treatment of peripheral arterial disease, and restoration of the foot function are necessary. [12] A lot of different factors playing a role in etiopathogenesis complicate the approach to be developed in this type of lesions, and therefore it requires a team concept. [13] In the empirical treatment, the objective should be treating only the potential agents. Adequate tissue levels, low side effects and patient compliance must be observed; effective drugs should be used in specified doses and duration. [14] Debridement is an essential and integral part of wound treatment and is an important tool allowing the formation of healthy granulation tissue. [15] When the infected tissue cannot be completely cleared with the debridement and in cases when the patient could not cope with the remaining infection load, performing a limb amputation on a safe level of infection would be lifesaving.
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- 2016
26. The Evaluation of Rabies-Suspicious Cases Admitted to Second Step Health Institution
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Yunus Yilmaz, Hatice Köse Özlece, Ayten Kadanali, Emsal Aydin, Hurrem Bodur, Sergülen Aydın, and Esragül Akinci
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03 medical and health sciences ,0302 clinical medicine ,business.industry ,Institution (computer science) ,medicine ,030208 emergency & critical care medicine ,Rabies ,030212 general & internal medicine ,Medical emergency ,medicine.disease ,business - Published
- 2016
27. A Case of Brucellosis due to Brucella melitensis Isolated from Epidural Abscess
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Sinan Ozturk, Sule Eren Cakar, Ayten Kadanali, Şenol Çomoğlu, Sait Naderi, Arzu Irvem, Ayşe Serra Özel, Gül Karagöz, and Nilsun Altunal
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Microbiology (medical) ,General Immunology and Microbiology ,Epidural abscess ,biology ,treatment ,business.industry ,lcsh:R ,lcsh:Medicine ,Brucellosis ,medicine.disease ,biology.organism_classification ,Microbiology ,lcsh:Infectious and parasitic diseases ,Infectious Diseases ,Bacterial infections ,decompression surgery ,medicine ,lcsh:RC109-216 ,business ,Brucella melitensis ,epidural abcess - Published
- 2017
28. An overview of Ebola virus disease
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Gül Karagöz and Ayten Kadanali
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medicine.medical_specialty ,Modern medicine ,diagnosis ,viruses ,030231 tropical medicine ,Ebola virus disease ,Disease ,Review ,medicine.disease_cause ,Virus ,Incubation period ,03 medical and health sciences ,Ebola Hemorrhagic Fever ,0302 clinical medicine ,Epidemiology ,medicine ,030212 general & internal medicine ,Intensive care medicine ,Ebola virus ,treatment ,business.industry ,Standard treatment ,Virology ,epidemiology ,business ,General Economics, Econometrics and Finance - Abstract
Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, is a severe, often fatal illness in humans. Ebola virus (EBOV) is transmitted through contact with blood or body fluids of a person who contracted or died from EVD, contaminated objects like needles and infected animals or bush meat. EVD has an incubation period of 2 to 21 days, and the infection has an acute onset without any carrier status. Currently, there is no standard treatment for EVD, so it is important to avoid infection or further spreading of the virus. Although historically the mortality of this infection exceeded 80%, modern medicine and public health measures have been able to lower this figure and reduce the impact of EBOV on individuals and communities. Its treatment involves early, aggressive supportive care with rehydration. Clinicians should consider the possibility of EVD in persons with travel or exposure history with the incubation period presenting constitutional symptoms in order to promptly identify diseased patients, and prevent further spreading of the disease.
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- 2015
29. Tuberculous and brucellosis meningitis differential diagnosis
- Author
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Sibel Bolukcu, Asli Haykir-Solay, Fatma Sirmatel, Melanie Catroux, Secil Deniz, Recep Tekin, Huseyin Turgut, Nefise Oztoprak, Hakan Erdem, Saygin Nayman-Alpat, Levent Gorenek, Selçuk Kaya, Serap Gencer, Meltem Avci, Mahmut Sunnetcioglu, Mustafa Namiduru, Mehmet Ulug, Kadriye Kart Yaşar, Gokhan Karaahmetoglu, Yves Hansmann, Tumer Guven, Rok Čivljak, Tuna Demirdal, Celal Ayaz, Mustafa Kemal Çelen, Isik Somuncu Johansen, Ayse Batirel, Ayten Kadanali, Oğuz Reşat Sipahi, Gonul Sengoz, Emel Yilmaz, Rodrigo Hasbun, Selma Ates-Guler, Ali İrfan Baran, Yasemin Cag, Hasan Karsen, Affan Denk, Emine Parlak, Ayşe Seza Inal, Filiz Pehlivanoglu, Hanefi Cem Gul, Ayhan Akbulut, Elif Sahin-Horasan, Soline Simeon, Seniha Senbayrak, Esmeray Mutlu-Yilmaz, Sukran Kose, Selma Tosun, Abdullah Umut Pekok, Mustafa Kasim Karahocagil, and Çukurova Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Tuberculosis ,Scoring system ,Turkey ,retrospective study ,urologic and male genital diseases ,Article ,Brucellosis ,Tuberculous meningitis ,Meningitis, Bacterial ,Diagnosis, Differential ,Young Adult ,Internal medicine ,differential diagnosis ,middle aged ,Diagnosis ,medicine ,Humans ,agglutination test ,controlled study ,Meningitis ,human ,Retrospective Studies ,business.industry ,Public Health, Environmental and Occupational Health ,meningoencephalitis ,scoring system ,Meningoencephalitis ,medicine.disease ,major clinical study ,Surgery ,female ,Infectious Diseases ,priority journal ,tuberculous meningitis ,Tuberculosis, Meningeal ,Etiology ,Differential diagnosis ,business ,cerebrospinal fluid culture - Abstract
PubMedID: 25801665 SummaryBackground The Thwaites and Lancet scoring systems have been used in the rapid diagnosis of tuberculous meningitis (TBM). However, brucellar meningoencephalitis (BME) has similar characteristics with TBM. The ultimate aim of this study is to infer data to see if BME should be included in the differential diagnosis of TBM when these two systems suggest the presence of TBM. Method BME and TBM patients from 35 tertiary hospitals were included in this study. Overall 294 adult patients with BME and 190 patients with TBM were enrolled. All patients involved in the study had microbiological confirmation for either TBM or BME. Finally, the Thwaites and Lancet scoring systems were assessed in both groups. Results The Thwaites scoring system more frequently predicted BME cases (n = 292, 99.3%) compared to the TBM group (n = 182, 95.8%) (P = 0.017). According to the Lancet scoring system, the mean scores for BME and TBM were 9.43 ± 1.71 and 11.45 ± 3.01, respectively (P < 0.001). In addition, TBM cases were classified into "probable" category more significantly compared to BME cases, and BME cases were categorized into the "possible" category more frequently. Conclusions When the Thwaites or Lancet scoring systems indicate TBM, brucellar etiology should also be taken into consideration particularly in endemic countries. © 2015 Elsevier Ltd. All rights reserved.
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- 2015
30. Influence of multidrug resistant organisms on the outcome of diabetic foot infection
- Author
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Nazan Tuna, Mucahit Yemisen, Filiz Pehlivanoglu, Oguz Karabay, Buket Erturk, Necla Tulek, Omer Coskun, Fatma Yilmaz, Nuray Uzun, Yasar Kucukardali, Nurgul Ceran, Kadriye Kart Yaşar, Oznur Ak, Turan Aslan, Taner Yildirmak, Nail Ozgunes, Lutfiye Mulazimoglu, Atahan Cagatay, Tuna Demirdal, Ayse Batirel, Fatma Sargin, Haluk Eraksoy, Ayten Kadanali, Gulsen Yoruk, Salih Atakan Nemli, Derya Öztürk, Oral Oncul, Gül Karagöz, Onder Ergonul, Nese Saltoglu, Yasemin Akkoyunlu, Meral Sonmezoglu, Hakan Ay, Cagla Sonmezer, Funda Şimşek, Gonul Sengoz, Serkan Surme, Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Saltoğlu, Neşe, Tülek, Necla, Yemisen, Mücahit, Kadanalı, Ayten, Karagöz, Gül, Batırel, Ayşe, Ak, Öznür, Sönmezer, Cağla, Eraksoy, Haluk, Cağatay, Atahan, Sürme, Serkan, Nemli, Salih A., Demirdal, Tuna, Coşkun, Ömer, Öztürk, Derya, Ceran, Nurgül, Pehlivanoğlu, Filiz, Şengoz, Gönül, Aslan, Turan, Akkoyunlu, Yasemin, Öncül, Oral, Ay, Hakan, Mülazımoğlu, Lütfiye, Ertürk, Buket, Yılmaz, Fatma, Yörük, Gülşen, Uzun, Nuray, Şimşek, Funda, Yıldırmak, Taner, Yaşar, Kadriye Kart, Sönmezoğlu, Meral, Küçükkardalı, Yaşar, Tuna, Nazan, Karabay, Oğuz, Özgüneş, Nail, Sargın, Fatma, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Saltoglu, Nese, Ergonul, Onder, Tulek, Necla, Yemisen, Mucahit, Kadanali, Ayten, Karagoz, Gul, Batirel, Ayse, Ak, Oznur, Sonmezer, Cagla, Cagatay, Atahan, Surme, Serkan, Coskun, Omer, Ozturk, Derya, Ceran, Nurgul, Pehlivanoglu, Filiz, Sengoz, Gonul, Akkoyunlul, Yasemin, Oncul, Oral, Mulazimoglu, Lutfiye, Erturk, Buket, Yilmaz, Fatma, Yoruk, Gulsen, Simsek, Funda, Yildirmak, Taner, Yasar, Kadriye Kart, Sonmezoglu, Meral, kucukardali, Yasar, Karabay, Oguz, Ozgunes, Nail, Sargin, Fatma, and AKKOYUNLU, YASEMİN
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Male ,Klebsiella ,genetic structures ,IMPACT ,Klebsiella pneumoniae ,MRSA ,medicine.disease_cause ,SOFT-TISSUE INFECTIONS ,0302 clinical medicine ,Diabetic foot infection ,030212 general & internal medicine ,Aged, 80 and over ,biology ,Fatality ,Osteomyelitis ,General Medicine ,Middle Aged ,Diabetic Foot ,Drug Resistance, Multiple ,Anti-Bacterial Agents ,ULCERS ,TRIALS ,Infectious Diseases ,Staphylococcus aureus ,Pseudomonas aeruginosa ,Infectious diseases ,Female ,Microbiology (medical) ,Adult ,medicine.medical_specialty ,SOCIETY ,030209 endocrinology & metabolism ,ANTIBIOTIC-THERAPY ,Patient Readmission ,Amputation, Surgical ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Internal medicine ,medicine ,Escherichia coli ,Humans ,lcsh:RC109-216 ,STAPHYLOCOCCUS-AUREUS ,Aged ,business.industry ,medicine.disease ,biology.organism_classification ,Diabetic foot ,Multiple drug resistance ,Patient Outcome Assessment ,TURKEY ,RISK-FACTORS ,business ,Staphylococcus ,Saltoglu N., Ergonul O., TULEK N., Yemisen M., KADANALI A., KARAGOZ G., BATIREL A., AK O., SONMEZER C., Eraksoy H., et al., -Influence of multidrug resistant organisms on the outcome of diabetic foot infection-, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.70, ss.10-14, 2018 - Abstract
Objectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19-90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were rehospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, Cl: 1.82-38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, Cl: 1.24-47.96, p = 0.028), and chronic heart failure (OR: 3, Cl: 1.01-9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p < 0.001). Conclusion: Among rehospitalized patients, methicillin resistant Staphylococcus infections was detected as the most common agent, and Klebsiella spp. infections were found to be significantly associated with fatality. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
- Published
- 2017
31. The Frequency of Extended-spectrum Beta-lactamase and The Rate of Antibiotic Resistance in Escherichia coli Strains
- Author
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Behiye Dede, Senol Comoglu, Ayten Kadanali, Gül Karagöz, Mehmet Fatih Bektaşoğlu, and Fatma Muhterem Yücel
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Imipenem ,medicine.medical_treatment ,lcsh:Medicine ,Tigecycline ,Biology ,medicine.disease_cause ,Meropenem ,Microbiology ,chemistry.chemical_compound ,Antibiotic resistance ,medicine ,polycyclic compounds ,Escherichia coli ,lcsh:R ,Public Health, Environmental and Occupational Health ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,chemistry ,ESBL ,Amikacin ,Antibiotic Resistance ,Beta-lactamase ,bacteria ,Ertapenem ,medicine.drug - Abstract
Background The resistance related with production of extended-spectrum beta-lactamase (ESBL) is an important problem that we face when we are treating infections caused by enterobacteriaceae. We aimed to evaluate the frequency of ESBL production in E. coli strains and the rate of antibiotic resistance isolated from in our microbiology laboratory. Method E. coli strains isolated from various clinical specimens between January 2010 – December 2011 were assessed retrospectively. Resistances to ESBL-producing and non-producing E. coli and the rate of ESBL production according to the years were investigated. The results were compared with statistical analysis. Results The rate of ESBL producing E. coli was 21.9% in 2010, and 25% in 2011. There was no resistance to imipenem, meropenem, ertapenem and tigecycline in all strains. The resistance to antibiotics other than amikacin was statistically significant in ESBL producing E. coli compared to ESBL non-producing E.coli (p
- Published
- 2013
32. Yoğun bakım ünitesinde izole edilen Acinetobacter baumannii suşlarının antibiyotik dirençlerinin araştırılması
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Fatma Muhterem Yücel, Ayten Kadanali, Gül Karagöz, Behiye Dede, Mehmet Fatih Bektaşoğlu, and Senol Comoglu
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Imipenem ,biology ,business.industry ,General Medicine ,Sulbactam ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,Tazobactam ,Meropenem ,Microbiology ,Acinetobacter baumannii ,Cefoperazone ,polycyclic compounds ,Colistin ,medicine ,bacteria ,business ,medicine.drug ,Piperacillin - Abstract
Objective: Acinetobacter baumannii is a gram negative, antimicrobial-resistant bacilli difficult to control and treat. This pathogen has became more important in the last decades due to multidrug-resistant nasocomial infections. The aim of this study was to determine the antibiotic resistance rates of A.baumannii isolated from various clinical specimens of intensive care unit (ICU) patients between November 2010 and December 2011. Material and Methods: A total of 172 A.baumannii strains were isolated. Identification and antibiotic susceptibility testing were performed by VITEC 2 (bioMerieux, France) system. Results: A. baumannii strains were isolated 44% from tracheal aspirate, 25% from wounds, 24% from blood, and 7% from urine, consecutively. Although there were no resistant strains detected to colistin and tygecycline, resistance rates of the other antibiotics were found to be 64% for amicacin, 67% for gentamicin, %73 for levosoxacin, 76% for ciprosoxacin, %79 for cefoperazone/sulbactam, 84% for piperacillin/tazobactam, and 92% for imipenem and meropenem, consecutively. Conclusion: In conclusion, no resistant strains were detected to colistin and tygecycline and they were found to be the preferred empirical treatment for A. baumannii infections.
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- 2013
33. Frequency of Rotavirus in Children with Acute Gastroenteritis
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Tuba Kayman, F. Muhterem Yücel, Ahmet Vural, Behiye Dede, Hakan Aylanç, Arzu Irvem, Nazan Kaymaz, Naci Topaloğlu, Ayten Kadanali, Fatih Battal, Köksal Binnetoğlu, Mustafa Yildirim, Elife Berk, Şule Yıldırım, Mustafa Tekin, and Esra Başer
- Subjects
Rotavirus Antigen ,Rapid diagnostic test ,Pediatrics ,medicine.medical_specialty ,Seasonal distribution ,medicine.drug_class ,business.industry ,Medical record ,Antibiotics ,General Engineering ,Acute gastroenteritis ,medicine.disease_cause ,Rotavirus ,medicine ,Outpatient clinic ,business - Abstract
It is important to follow up the epidemiologic and clinical characteristics of the viral especially rotavirus gastroenteritis to develop strategies for prevention and treatment. Therefore we investigated the rotavirus gastroenteritis in acute diarrhea patinets in our clinic. Stool samples of 263 patients admitted to outpatient clinic or emergency room of COMU Faculty of Medicine Hospital with the symptom of acute diarrhea were screened retrospectively from medical records. Stool samples had been studied with the monoclonal antibody based chromatographic immunoassay (Rota-Adeno Virus Combo Test Device, Ecotest, China). 263 medical records were screened. Rotavirus antigen was positive in 62 cases (23.6%). It was 34.5% in children under 2 years. Rota positivity according to the seasons was as follows: 27.8% in spring, 14.6% in summer, 26.3% in autumn and 21.4% in winter. As a result, acute diarrhea case management should be done for age and seasonal distribution. In these cases unnecessary antibiotic usage should be avoided by rapid diagnostic test when required.
- Published
- 2012
34. An Evaluation of Surgical Prophylaxis Procedures in Turkey: A Multi-Center Point Prevalence Study
- Author
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Alper Gunduz, Tulin Elmaslar, Recep Tekin, Derya Caglayan, Nefise Oztoprak, Seyhan Aktas, Pınar Firat, Ayten Kadanali, Aynur Aynioglu, Hava Yilmaz, Sevinc Yenice, Selçuk Kaya, Nilgun Fidan Kocyigit, Ilkay Bozkurt, Semiha Solak, Sule Eren Cakar, Firdevs Aksoy, Seniha Senbayrak, Ayşe Sağmak Tartar, Iftihar Koksal, Ahsen Oncul, Zonguldak Bülent Ecevit Üniversitesi, and OMÜ
- Subjects
0301 basic medicine ,genetic structures ,Turkey ,business.industry ,030106 microbiology ,Prevalence ,General Medicine ,Bioinformatics ,medicine.disease ,antibiotics ,03 medical and health sciences ,Surgical prophylaxis ,medicine ,Original Article ,Center (algebra and category theory) ,Medical emergency ,business - Abstract
WOS: 000373481300007, PubMed: 27026760, Objective: The purpose of this study was to evaluate compliance with guidelines in surgical prophylaxis (SP) procedures in Turkey. Materials and Methods: A point prevalence study involving 4 university, 5 education and research and 7 public hospitals was performed assessing compliance with guidelines for antibiotic use in SP. Compliance was based on the "Clinical Practice Guidelines for Antimicrobial Surgery (CPGAS) 2013" guideline. Results: Sixteen centers were included in the study, with 166 operations performed at these being evaluated. Parenteral antibiotic for SP was applied in 161 (96.9%) of these. Type of antibiotic was inappropriate in 66 (40.9%) cases and duration of use in 47 (29.1%). The main antibiotics used inappropriately in SP were ceftriaxone, glycopeptides and aminoglycosides. No significant difference was observed between secondary and tertiary hospitals in terms of inappropriate selection. Duration of prophylaxis was also incompatible with guideline recommendations in approximately half of surgical procedures performed in both secondary and tertiary hospitals, however statistical significance was observed between institutions in favor of tertiary hospitals. Conclusion: Antibiotics are to a considerable extent used in a manner incompatible with guidelines even in tertiary hospitals in Turkey. It must not be forgotten that several pre-, intra- and postoperative factors can be involved in the development of surgical site infections (SSI), and antibiotics are not the only option available for preventing these. A significant improvement can be achieved in prophylaxis with close observation, educational activities, collaboration with the surgical team and increasing compliance with guidelines. All health institutions must establish and apply their own SP consensus accompanied by the guidelines in order to achieve success in SP.
- Published
- 2016
35. Impact of antimicrobial drug restrictions on doctors? behaviors
- Author
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Serife Akalin, Mahmut Sunnetcioglu, Aygul Dogan Celik, Salih Hosoglu, Gürdal Yilmaz, Abdulkadir Küçükbayrak, Tumer Guven, Ibak Gonen, Serpil Erol, Oguz Karabay, Koçoğlu Me, Unal Erkorkmaz, Işıkgöz Taşbakan M, Omer Faruk Kokoglu, Ertugrul Guclu, Nurettin Erben, Demirli K, Tuna Demirdal, B. Dede, Fatma Aybala Altay, Ertan Aydin, Turhan, Güner Ae, Bahadir Ceylan, Ömer Evirgen, Recep Tekin, Ilhami Celik, Sebnem Senol, Fatma Sargin, Ayten Kadanali, BAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Koçoğlu, Mücahide Esra, Küçükbayrak, Abdulkadir, Ege Üniversitesi, Karabay, O, Hosoglu, S, Guclu, E, Akalin, S, Altay, FA, Aydin, E, Ceylan, B, Celik, A, Celik, I, Demirdal, T, Demirli, K, Erben, N, Erkorkmaz, U, Erol, S, Evirgen, O, Gonen, I, Guner, AE, Guven, T, Kadanali, A, Kocoglu, ME, Kokoglu, OF, Kucukbayrak, A, Sargin, F, Sunnetcioglu, M, Senol, S, Isikgoz Tasbakan, M, Tekin, R, Turhan, V, Yilmaz, G, Dede, B, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Karabay, Oğuz, Güçlü, Ertuğrul, Erkorkmaz, Ünal, and Hatay Mustafa Kemal Üniversitesi
- Subjects
0301 basic medicine ,Budget Execution İnstructions ,medicine.medical_specialty ,Antibiotic Usage ,Turkey ,medicine.drug_class ,specialist ,030106 microbiology ,Antibiotics ,Disease ,budget execution instructions ,Specialist ,03 medical and health sciences ,Antibiotic policy ,antibiotic restriction ,antibiotic usage ,budget ,Anti-Infective Agents ,General & Internal Medicine ,Physicians ,Surveys and Questionnaires ,Antibiotic Policy ,medicine ,Intensive care medicine ,Cerrahi ,business.industry ,execution instructions ,Anti-Infective Agents/*pharmacology ,General Medicine ,Antimicrobial drug ,Infectious disease (medical specialty) ,Family medicine ,Antibiotic policy,antibiotic restriction,antibiotic usage,budget execution instructions,specialist ,business ,Antibiotic Restriction - Abstract
Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics., Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician., Results: A total of 1906 specialists from 20 cities in Turkey participated in the study. Of those who participated, 1271 (67.5%) had 5 years of occupational experience in their branch expressed that they followed the antibiotic guidelines more strictly than the JSs (P < 0.05) and 755 of physicians (88%) and 720 of surgeons (84.6%) thought that the AR policy was necessary and useful (P < 0.05)., Conclusion: This study indicated that the AR policy was supported by most of the specialists. Physicians supported this restriction policy more so than surgeons did.
- Published
- 2016
36. Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey
- Author
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Ayse Inci, Fatma Yılmaz Karadağ, Pınar Ergen, Saygin Nayman Alpat, Rezan Harman, Ilhami Celik, Filiz Koc, Hakan Erdem, Mehmet Bitirgen, Ilknur Yavuz, Nefise Oztoprak, Ayse Batirel, Banu Cakir, Mustafa Namiduru, Esmeray Mutlu Yilmaz, Kevser Ozdemir, Emsal Aydin, Yasemin Durdu, Kenan Ugurlu, Nevin Ince, Aynur Atilla, Büşra Ergüt Sezer, Emel Aslan, Serpil Erol, Mustafa Hatipoglu, Hatice Udurgucu, Mustafa Sunbul, Ayşe Erbay, Ercan Yenilmez, Hacer Deniz Ozkaya, Yeşim Alpay, Esma Gulesen Eroglu, Mehmet Faruk Geyik, Emine Parlak, Hüseyin Tarakçı, Rodrigo Hasbun, Gunes Senol, Aynur Aynioglu, Ilkay Bozkurt, Necati Örmeci, Recep Tekin, Seher Ayten Coskuner, Gokhan Karaahmetoglu, Ebru Dik, Zehra Karacaer, Suna Seçil Öztürk Deniz, Gulsen Iskender, Selma Tosun, Fatime Korkmaz, Ilker Inanc Balkan, Ergenekon Karagoz, Fatma Sirmatel, Suzan Sacar, Ömer Evirgen, Mustafa Dogan, Ayten Kadanali, Senol Comoglu, Rahmet Guner, Ahmet Şahin, Affan Denk, Elif Tukenmez Tigen, Ceyda Necan, Aliye Bastug, Ahmet Sahin, Cinar Ozturk, Hamdi Sözen, Çiğdem Kader, Mustafa Altindiş, Şafak Kaya, Selçuk Kaya, Mehmet Ulug, Servet Kolgelier, Gül Durmuş, Kamuran Turker, Ahmet Karakaş, Gülden Ersöz, Pinar Korkmaz, Rukiye Pinar Bölüktaş, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı, Şahin, Ahmet Melih, Karacaer, Zehra, Cakir, Banu, Erdem, Hakan, Ugurlu, Kenan, Durmus, Gul, Ince, Nevin Koc, Ozturk, Cinar, Hasbun, Rodrigo, Batirel, Ayse, Yilmaz, Esmeray Mutlu, Bozkurt, Ilkay, Sunbul, Mustafa, Aynioglu, Aynur, Atilla, Aynur, Erbay, Ayse, Inci, Ayse, Kader, Cigdem, Tigen, Elif Tukenmez, Karaahmetoglu, Gokhan, Coskuner, Seher Ayten, Dik, Ebru, Tarakci, Huseyin, Tosun, Selma, Korkmaz, Fatime, Kolgelier, Servet, Karadag, Fatma Yilmaz, Erol, Serpil, Turker, Kamuran, Necan, Ceyda, Sahin, Ahmet Melih, Ergen, Pinar, Iskender, Gulsen, Korkmaz, Pinar, Eroglu, Esma Gulesen, Durdu, Yasemin, Ulug, Mehmet, Deniz, Suna Secil, Koc, Filiz, Alpat, Saygin Nayman, Oztoprak, Nefise, Evirgen, Omer, Sozen, Hamdi, Dogan, Mustafa, Kaya, Selcuk, Kaya, Safak, Altindis, Mustafa, Aslan, Emel, Tekin, Recep, Sezer, Busra Ergut, Ozdemir, Kevser, Ersoz, Gulden, Sahin, Ahmet, Celik, Ilhami, Aydin, Emsal, Bastug, Aliye, Harman, Rezan, Ozkaya, Hacer Deniz, Parlak, Emine, Yavuz, Ilknur, Sacar, Suzan, Comoglu, Senol, Yenilmez, Ercan, Sirmatel, Fatma, Balkan, Ilker Inanc, Alpay, Yesim, Hatipoglu, Mustafa, Denk, Affan, Senol, Gunes, Bitirgen, Mehmet, Geyik, Mehmet Faruk, Guner, Rahmet, Kadanali, Ayten, Karakas, Ahmet, Namiduru, Mustafa, Udurgucu, Hatice, Boluktas, Rukiye Pinar, Karagoz, Ergenekon, Ormeci, Necati, Karacaer, Z, Cakir, B, Erdem, H, Ugurlu, K, Durmus, G, Ince, NK, Ozturk, C, Hasbun, R, Batirel, A, Yilmaz, EM, Bozkurt, I, Sunbul, M, Aynioglu, A, Atilla, A, Erbay, A, Inci, A, Kader, C, Tigen, ET, Karaahmetoglu, G, Coskuner, SA, Dik, E, Tarakci, H, Tosun, S, Korkmaz, F, Kolgelier, S, Karadag, FY, Erol, S, Turker, K, Necan, C, Sahin, AM, Ergen, P, Iskender, G, Korkmaz, P, Eroglu, EG, Durdu, Y, Ulug, M, Deniz, SS, Koc, F, Alpat, SN, Oztoprak, N, Evirgen, O, Sozen, H, Dogan, M, Kaya, S, Altindis, M, Aslan, E, Tekin, R, Sezer, BE, Ozdemir, K, Ersoz, G, Sahin, A, Celik, I, Aydin, E, Bastug, A, Harman, R, Ozkaya, HD, Parlak, E, Yavuz, I, Sacar, S, Comoglu, S, Yenilmez, E, Sirmatel, F, Balkan, II, Alpay, Y, Hatipoglu, M, Denk, A, Senol, G, Bitirgen, M, Geyik, MF, Guner, R, Kadanali, A, Karakas, A, Namiduru, M, Udurgucu, H, Boluktas, RP, Karagoz, E, Ormeci, N, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Altındiş, Mustafa, Tıp Fakültesi, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Öztürk, Çınar, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sözen, Hamdi, Zonguldak Bülent Ecevit Üniversitesi, Halk Sağlığı, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sırmatel, Fatma, and OMÜ
- Subjects
antivirus agent ,Male ,demography ,MARITAL-STATUS ,Turkey ,Cross-sectional study ,IMPACT ,Disease ,DETERMINANTS ,Turkey (republic) ,0302 clinical medicine ,Quality of life ,antiviral therapy ,Health Status Indicators ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,The Hepatitis B Quality of Life Instrument ,food and beverages ,clinical trial ,General Medicine ,Middle Aged ,Hepatitis B ,humanities ,Chronic hepatitis B infection ,Female ,030211 gastroenterology & hepatology ,HEALTH ,prospective study ,Adult ,medicine.medical_specialty ,Chronic Hepatitis B Infection ,quality of life assessment ,psychology ,Antiviral Agents ,Article ,Interviews as Topic ,03 medical and health sciences ,Hepatitis B, Chronic ,Chronic hepatitis ,UTILITIES ,Internal medicine ,medicine ,cross-sectional study ,Humans ,chronic hepatitis B ,controlled study ,human ,Aged ,Related factors ,business.industry ,Research ,fungi ,Public Health, Environmental and Occupational Health ,Hepatitis B Quality of Life ,interview ,medicine.disease ,major clinical study ,COMORBIDITIES ,hepatitis B surface antigen ,multicenter study ,Cross-Sectional Studies ,Health Care Sciences & Services ,Short Form 36 ,Multi center study ,Physical therapy ,Quality of Life ,business ,health status indicator - Abstract
WOS: 000386954300001, PubMed: 27809934, Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.
- Published
- 2016
37. Assessment of Health-Related Quality of Life in Chronic Hepatitis B Infection Patients in Turkey: A Multicenter Study
- Author
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H. Udurgucu, Emel Aslan, S. Kölgelier, Y. Durdu, Nevin Ince, Ömer Evirgen, Çiğdem Kader, Recep Tekin, Senol Comoglu, Ercan Yenilmez, Büşra Ergüt Sezer, Ilkay Bozkurt, Esmeray Mutlu Yilmaz, Cinar Ozturk, Mehmet Faruk Geyik, A. Inci, Aynur Atilla, Serpil Erol, Ceyda Necan, Şafak Kaya, Gokhan Karaahmetoglu, Aynur Aynioglu, Emine Parlak, Seher Ayten Coskuner, Gulsen Iskender, Pınar Ergen, Kenan Ugurlu, Mustafa Hatipoglu, E.G. Eroglu, Ilknur Yavuz, Rahmet Guner, Yeşim Alpay, Altan Sahin, Hacer Deniz Ozkaya, Gunes Senol, Suna Seçil Öztürk Deniz, Ahmet Karakaş, Mehmet Ulug, Selma Tosun, Mustafa Altindiş, Ayse Batirel, Pinar Korkmaz, N.O. Cuvalci, Fatma Yılmaz Karadağ, Saygin Nayman Alpat, Rezan Harman, Affan Denk, Elif Tukenmez Tigen, Ilker Inanc Balkan, Hüseyin Tarakçı, Banu Cakir, Mustafa Namiduru, Ayşe Erbay, Hamdi Sözen, Filiz Koc, Hakan Erdem, Mustafa Sunbul, Rukiye Pinar Bölüktaş, E. Dik, Ayten Kadanali, Emsal Aydin, Aliye Bastug, Zehra Karacaer, Ahmet Sahin, Kevser Ozdemir, Suzan Sacar, Fatime Korkmaz, Mustafa Dogan, Gül Durmuş, Ilhami Celik, Fatma Sirmatel, Mehmet Bitirgen, Gülden Ersöz, K. Turker, Giresun Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, and Ondokuz Mayıs Üniversitesi
- Subjects
Health related quality of life ,medicine.medical_specialty ,Hepatology ,Multicenter study ,Chronic hepatitis ,business.industry ,Internal medicine ,medicine ,business - Abstract
EASL International Liver Congress -- APR 13-17, 2016 -- -- Barcelona, SPAIN, WOS: 000398711700582, …, EASL
- Published
- 2016
38. Hepatitis C Virus Related Liver Dysfunction During Chemotherapy for Hodgkin’s Lymphoma
- Author
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Zülal Özkurt, Ayten Kadanali, Serpil Erol, İlhami Kiki, and Mehmet Parlak
- Subjects
medicine.medical_specialty ,Chemotherapy ,business.industry ,Hepatitis C virus ,medicine.medical_treatment ,virus diseases ,Hematology ,medicine.disease_cause ,medicine.disease ,Hodgkin's lymphoma ,Gastroenterology ,digestive system diseases ,Lymphoma ,Oncology ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Liver dysfunction ,business - Abstract
Concurrent Hodgkin’s lymphoma and Hepatitis C virus (HCV) infection is a rare clinical condition. Also, HCV related liver dysfunction during lymphoma chemotherapy is uncommon and most data come from patients with non-Hodgkin’s lymphoma. We reported here a case of HCV related liver dysfunction during chemotherapy for Hodgkin’s lymphoma and long term follow-up results of the patient, and we reviewed the literature.
- Published
- 2012
39. Crimean-Congo Hemorrhagic Fever Virus Infection: Clinical and Laboratory Observations and Predictors of Fatality
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Serpil Erol, Kemalettin Özden, and Ayten Kadanali
- Subjects
business.industry ,Medicine ,General Medicine ,business ,Virology ,Crimean Congo hemorrhagic fever virus - Published
- 2012
40. Brucellosis with cervical vertebrae and pulmonary involvement: A rare case
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Gül Karagöz, Şenol Çomoğlu, Mehmet Resid Onen, Behiye Dede, Nur Betul Unal Ozdemir, and Ayten Kadanali
- Subjects
Spondylodiscitis ,medicine.medical_specialty ,lcsh:QR1-502 ,Pharmaceutical Science ,Brucella ,lcsh:Microbiology ,Ground-glass opacity ,Biopsy ,medicine ,pulmonary involvement ,Pharmacology (medical) ,Lung ,biology ,medicine.diagnostic_test ,business.industry ,Brucellosis ,cervical vertebrae ,medicine.disease ,biology.organism_classification ,Surgery ,medicine.anatomical_structure ,Complementary and alternative medicine ,brucellosis ,Bacterial infection ,medicine.symptom ,business ,Cervical vertebrae ,Brucella melitensis - Abstract
The spine is the most common site of musculoskeletal involvement of brucellosis. However, there is no case report presented in the literature of both cervical vertebrae spondylodiscitis and pulmonary involvement of brucella. We reported a 52-year-old woman complaining for one month of fever with rigors, fatigue, malaise, pain on the neck and arm, and sweating. The Wright agglutination test for brucella was positive at titers of 1/640. MRI of the cervical vertebrae was consistent with spondylodiscitis and paravertebral and epidural abscesses. Ground glass opacity was seen in the left upper lobe on CT scanning of the chest. Percutaneous image-guided biopsy was performed and Brucella melitensis was isolated. The patient was treated with streptomycin for 3 weeks, plus doxycycline and rifampicin for 3 months. We recommend tissue culture for brucella patients with lung lesions. Isolation of the microorganism from a biopsy material provides conclusive evidence. J Microbiol Infect Dis 2015;5(4): 173-175 Key words: Bacterial infection, brucellosis, cervical vertebrae, pulmonary involvement, spondylodiscitis
- Published
- 2015
41. Noninvasive models to predict liver fibrosis in patients with chronic hepatitis B: a study from Turkey
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Ergenekon Karagoz, Esma Yuksel, Gunay Tuncer Ertem, Cahide Sacligil, Kaya Suer, Füsun Zeynep Akçam, Hayrettin Akdeniz, İhsan Çelik, Selcan Arslan Ozel, Unal Cagir, Murat Sayan, Pinar Korkmaz, Derya Keten, Alper Şener, Zerrin Yulugkural, Sinan Ozturk, Aysel Kocagul Celikbas, Eyup Arslan, Nese Saltoglu, Yeşim Alpay, Zehra Beştepe Dursun, Fatma Sirmatel, Hüseyin Şener Barut, Selmin Dirgen Çaylak, Bilgehan Aygen, Neşe Demirtürk, Muhammed Bekçibaşı, Arzu Tigli, Kemal Avsar, Asim Ulcay, Elif Sargin Altunok, Faruk Karakeçili, Gulfem Akengin Ocal, Sua Sumer, Gule Aydin, Ayse Batirel, Burcu Bayrak, O. Ural, Alpaslan Tanoglu, Sıla Akhan, Ahmet Cem Yardimci, H. Tarakci, Fatma Yılmaz Karadağ, Rezan Harman, Aynur Aynioglu, Neslihan Demir, Ayten Kadanali, Salih Atakan Nemli, Fatime Korkmaz, Necla Tulek, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Dirgen Çaylak, Selmin, Selçuk Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sırmatel, Fatma, Akdeniz, Hayrettin, and Tıp Fakültesi
- Subjects
HBsAg ,medicine.medical_specialty ,Cirrhosis ,animal structures ,Liver fibrosis ,Noninvasive Models ,education ,Gastroenterology ,Transaminase ,03 medical and health sciences ,0302 clinical medicine ,Chronic hepatitis ,Fibrosis ,Internal medicine ,medicine ,In patient ,Mean platelet volume ,health care economics and organizations ,medicine.diagnostic_test ,Hepatology ,business.industry ,Red blood cell distribution width ,medicine.disease ,Infectious Diseases ,Liver ,030220 oncology & carcinogenesis ,Liver biopsy ,030211 gastroenterology & hepatology ,Chronic Hepatitis B ,Hepatic fibrosis ,business - Abstract
Alpay, Yeşim (Balikesir Author), "Background: Manynoninvasive methods, including aspartateaminotransaminase (AST)/alanineaminotransaminase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), fibrosis-4 (FIB4) index, and age-platelet index (API), have been described to determine the stage of hepatic fibrosis. However, thesemethodsare developed for patients with chronic hepatitisC(CHC) andproduce conflicting results in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Objectives: The aim of this study was to evaluate the relationship between 7 noninvasive models, including AAR, APRI, CDS, API, FIB-4, neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-to-platelet ratio (RPR) in patients with CHB. Methods: The study population included all patients with CHB, undergoing liver biopsy to determine HBsAg and HBV DNA positivity in more than 6 months. Results: A total of 2520 treatment-naive CHB patients from 40 different centers were included in the study. In total, 62.6% of the patients were male, and the mean age was 40.60 +/- 12.34 years (minimum, 18 years; maximum, 77 years). The Ishak fibrosis score was >= 3 in 29.8% of the patients, indicating significant fibrosis. The mean API, APRI, CDS, NLR, FIB4, and RPR scores in the noninvasive models were significantly different between the groups with significant and low fibrosis (P < 0.05). All the noninvave models (API, APRI, AAR, CDS, NLR, RPR, and FIB4) were found to be significant in the discrimination of cirrhosis (P < 0.05). In the multiple logistic regression analysis, CDS, albumin, alkaline phosphatase (ALP), total bilirubin, neutrophil count, NLR, mean platelet volume (MPV), and FIB4 were independent indices for cirrhosis. Conclusions: In the present study, the role of noninvasive tests in the prediction of liver fibrosis stage and cirrhosis was evaluated in a large cohort of CHB patients. Overall, noninvasive models are gradually becoming more promising. Accordingly, the need for liver biopsy can be reduced with a combination of noninvasive methods in the future."
- Published
- 2017
42. Comment on 'Changes in acute viral hepatitis epidemiology in the Turkish adult population: A multicenter study'
- Author
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Fatma Yılmaz Karadağ, Serpil Erol, Nurgul Ceran, Funda Kocak, Zehra Karacaer, Ilknur Esen Yildiz, Ayse Albayrak, Selma Tosun, Canan Demir, Ercan Yenilmez, Serhat Uysal, Fatma Kaçar, Mehmet Parlak, Gül Karagöz, S. Sahin, Uğur Kostakoğlu, Ayten Kadanali, Irem Altas, Nuretdin Kuzhan, Ozgur Dagli, Rıza Aytaç Çetinkaya, Özlem Aydin, Pınar Ergen, Ayse Batirel, Arzu Altunçekiç Yildirim, Gül Durmuş, Derya Bayırlı Turan, and Türkkan Öztürk Kaygusuz
- Subjects
Male ,Adult ,Turkish population ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Hepatitis, Viral, Human ,Turkey ,Turkish ,030231 tropical medicine ,Adult population ,medicine.disease_cause ,acute viral hepatitis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Fulminant hepatitis ,Letter to the Editor ,Aged ,Retrospective Studies ,Hepatitis B virus ,Hepatitis ,Aged, 80 and over ,business.industry ,Gastroenterology ,Length of Stay ,Middle Aged ,Hepatitis A ,Hepatitis B ,medicine.disease ,language.human_language ,Vaccination ,Multicenter study ,Acute Disease ,language ,Female ,epidemiology ,Original Article ,Viral hepatitis ,business - Abstract
Background/aims The present study aimed to determine the changes in the epidemiology of hepatitis in recent years in an adult Turkish population. Materials and methods Overall, 852 patients with acute viral hepatitis from 17 centers were included in this study. Their sociodemographic characteristics, clinical courses, treatments, and laboratory findings were retrospectively analyzed. Results The most commonly found microorganisms were the hepatitis B virus (55.2%) and hepatitis A virus (37.6%), and the types of acute viral hepatitis differed significantly according to the age group (p≤0.001). The most frequently reported symptom was fatigue (73.7%), and the most common complications were cholecystitis (0.4%) and fulminant hepatitis (0.4%). The median hospital stay was 9 days (range 1-373). In total, 40.8% patients with acute hepatitis B virus developed immunity. Conclusion In Turkey, there are significantly large adolescent and adult populations susceptible to acute viral hepatitis. Therefore, larger vaccination programs covering these age groups should be implemented.
- Published
- 2018
43. Predictors for limb loss among patient with diabetic foot infections: an observational retrospective multicentric study in Turkey
- Author
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Gonul Sengoz, Nazan Tuna, U. Tozalgan, Funda Şimşek, Oguz Karabay, Kadriye Kart Yaşar, Meral Sonmezoglu, Asli Vatan, Fahri Yilmaz, B. Erturk, M. Ozyazar, Onder Ergonul, Fatma Sargin, Serdar Özer, Yasar Kucukardali, Atahan Cagatay, Nurgul Ceran, Hakan Ay, Ayse Batirel, Yasemin Akkoyunlu, Mucahit Yemisen, Filiz Pehlivanoglu, Derya Ozturk Engin, Ayten Kadanali, Lutfiye Mulazimoglu, Haluk Eraksoy, Oral Oncul, Taner Yildirmak, Nuray Uzun, Nail Ozgunes, Oznur Ak, Gül Karagöz, Nese Saltoglu, Turan Aslan, AKKOYUNLU, YASEMİN, Saltoglu, N., Yemisen, M., Ergonul, O., Kadanali, A., Karagoz, G., Batirel, A., Ak, O., Eraksoy, H., Cagatay, A., Vatan, A., Sengoz, G., Pehlivanoglu, F., Aslan, T., Akkoyunlu, Y., Engin, D., Ceran, N., Erturk, B., Mulazimoglu, L., Oncul, O., Ay, H., Sargin, F., Ozgunes, N., Simsek, F., Yildirmak, T., Tuna, N., Karabay, O., Yasar, K., Uzun, N., Kucukardali, Y., Sonmezoglu, M., Yilmaz, F., Tozalgan, U., Ozer, S., and Ozyazar, M.
- Subjects
Male ,Microbiology (medical) ,medicine.medical_specialty ,Turkey ,medicine.medical_treatment ,Antimicrobial resistance ,Amputation, Surgical ,Risk Factors ,Diabetes mellitus ,Internal medicine ,OSTEOMYELITIS ,MANAGEMENT ,medicine ,Humans ,EPIDEMIOLOGY ,infections ,LOWER-EXTREMITY AMPUTATION ,Aged ,Retrospective Studies ,an observational retrospective multicentric study in Turkey-, CLINICAL MICROBIOLOGY AND INFECTION, cilt.21, ss.659-664, 2015 [Saltoglu N., Yemisen M., Ergonul O., KADANALI A., KARAGOZ G., BATIREL A., AK O., Eraksoy H., Cagatay A., Vatan A., et al., -Predictors for limb loss among patient with diabetic foot infections] ,medicine.diagnostic_test ,Vascular disease ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,limb loss ,Diabetic foot ,Gram-negative ,Surgery ,Infectious Diseases ,Amputation ,Erythrocyte sedimentation rate ,Cellulitis ,Etiology ,Female ,business ,diabetic foot ,Retinopathy - Abstract
We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of limb loss were investigated by multivariate analysis. In total, 455 patients with DFI were included. Median age was 61 years, 68% were male, 65% of the patients were hospitalized, 52% of the patients had used antibiotics within the last month, and 121(27%) had osteomyelitis. Of the 208 microorganisms isolated, 92 (44.2%) were Gram-positive cocci and 114 (54.8%) were Gram-negative rods (GNR). The most common GNR was Pseudomonas; the second was Escherichia coli, with extended spectrum beta-lactamase positivity of 33%. Methicillin-resistant Staphylococcus species were found in 14% (29/208). Amputations were performed in 126/455 (28%) patients, 44/126 (34%) of these were major amputations. In multivariate analysis, significant predictors for limb loss were, male gender (OR 1.75, 95% Cl 1.04-2.96, p 0.034), duration of diabetes >20 years (OR 1.9, 95% Cl 1.18-3.11, p 0.008), infected ulcer versus cellulitis (OR 1.9, 95% Cl 1.11-3.18, p 0.019), history of peripheral vascular disease (OR 2, 95% Cl 1.26-3.27, p 0.004), retinopathy (OR 2.25, 95% Cl 1.19-4.25, p 0.012), erythrocyte sedimentation rate >70 mm/hr (OR 1.6, 95% Cl 1.01-2.68, p 0.05), and infection with GNR (OR 1.8, 95% Cl 1.08-3.02, p 0.02). Multivariate analysis revealed that, besides the known risk factors such as male gender, duration of diabetes >20 years, infected ulcers, history of peripheral vascular disease and retinopathy, detection of GNR was a significant predictor of limb loss. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
- Published
- 2015
44. Frequency of Rotavirus in Children with Acute Gastroenteritis
- Author
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Arzu Irvem, F. Muhterem Yücel, Mustafa Yildirim, Ayten Kadanali, and Behiye Dede
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Rotavirus ,Medicine ,Acute gastroenteritis ,business ,medicine.disease_cause - Published
- 2015
45. 99mTc-HMPAO labelled leucocyte scintigraphy in the diagnosis of pelvic inflammatory disease
- Author
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Mustafa Yildirim, Hatice Uslu, Erhan Varoglu, Ayten Kadanali, Rezzan Bayrakdar, and Sedat Kadanali
- Subjects
Adult ,medicine.medical_specialty ,Peritonitis ,Disease ,Scintigraphy ,Sensitivity and Specificity ,Sepsis ,Technetium Tc 99m Exametazime ,Pelvic inflammatory disease ,Leukocytes ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Abdominal Abscess ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Female ,Radiology ,Radiopharmaceuticals ,business ,Pelvic Inflammatory Disease - Abstract
Background Scintigraphy using leucocytes labelled with 99m Tc hexamethylpropyleneamine oxime ( 99m Tc-HMPAO) is widely used for the localization of inflammatory foci and abscesses in cases of acute pelvic inflammatory disease, which is one of the serious health problems of women of child-bearing age. Early diagnosis and effective management of this condition can preserve fertility and prevent serious complications, such as peritonitis and sepsis. Aim To evaluate the importance of scintigraphy using 99m Tc-HMPAO labelled leucocytes in the early diagnosis of patients with pelvic inflammatory disease. Methods Fifteen women (mean age 29.2 ± 8 years, range 25-46 years) with suspicion of pyogenic pelvic inflammatory disease based on gynaecological examinations, clinical findings and blood tests were included in this study. The patients received 555 MBq 99m Tc-HMPAO labelled leucocytes, by injection, and were scanned by scintigraphy 0.5-1, 3 and 24 h later in the anterior abdominal projection. Ten of the patients were then evaluated by abdominal or transvaginal ultrasonography, four by computed tomography and two by both ultrasound and computed tomography. The final diagnosis was made by surgical intervention. Results Scintigraphy detected pelvic inflammatory disease in five of the patients. In three of them the disease was apparent on the scans taken at 0.5-1 h, and in the other two it was apparent at 3 h. There were no false negative results, and one false positive result. The scan accurately reflected the absence of pelvic inflammatory disease in nine patients showing non-pathological tracer uptake in the lower abdominal region. Conclusion We showed that scintigraphy with 99m Tc-HMPAO labelled leucocytes had a sensitivity of 100%, specificity of 90%, overall accuracy of 93%, positive predictive value of 83%, and negative predictive value of 100%. Therefore, we conclude that 99m Tc-HMPAO labelled leucocyte scans provide a rapid and highly accurate method for diagnosing pelvic inflammatory disease in women of child-bearing age. This adds an important contribution to the diagnosis of infection and helps determine further operative or conservative treatment.
- Published
- 2006
46. Maternal carriage and neonatal colonisation of group B streptococcus in eastern Turkey: prevalence, risk factors and antimicrobial resistance
- Author
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Sedat Kadanali, Ayten Kadanali, and Ulku Altoparlak
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Obstetrics ,Cefazolin ,Clindamycin ,Erythromycin ,General Medicine ,medicine.disease_cause ,Group B ,Colonisation ,Carriage ,Streptococcus agalactiae ,Ampicillin ,Medicine ,business ,reproductive and urinary physiology ,medicine.drug - Abstract
Our object is to determine the prevalence of group B streptococcus (GBS) carriage among pregnant women, the neonatal colonisation rate and the antimicrobial susceptibility to formulate a policy for treatment and prevention regarding perinatal GBS diseases in eastern Turkey. A total of 150 pregnant women were screened for GBS colonisation. Samples were collected from the vagina and the rectum of pregnant women, and the ear canal, throat and umbilicus of the neonates of colonised mothers. Antimicrobial susceptibility of the isolates was also investigated. GBS was isolated in at least one specimen from the 150 women in 48 cases; it was estimated that, overall, about 32% of the pregnant women and 17.3% of overall newborns were colonised with GBS. The overall rate of GBS vertical transmission was 54.2% in this study. Maternal colonisation rate was significantly higher in younger ages (p < 0.01) when maternal age of 20 years was taken as a cut-off point. All isolates were found to be sensitive to penicillin, ampicillin, cefazolin and vancomycin. Resistance to erythromycin and clindamycin were found to be 13.5 and 2.7%, respectively.
- Published
- 2005
47. Aortic and Mitral Valve Endocarditis Caused by Brucella melitensis: A Case Report
- Author
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Ayten Kadanali, Senol Comoglu, Sinan Ozturk, Zeynep Sule Cakar, Nuran Gunay, and Gül Karagöz
- Subjects
Microbiology (medical) ,Mitral valve endocarditis ,medicine.medical_specialty ,Infectious Diseases ,biology ,business.industry ,Internal medicine ,Cardiology ,Medicine ,business ,biology.organism_classification ,Brucella melitensis - Published
- 2016
48. Hepatitis C Virus Infection in the Patients with Type 2 Diabetes Mellitus
- Author
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Serpil EROL, İlyas ÇAPOĞLU, Halil YAZGI, Ömer YILMAZ, and Ayten KADANALI
- Subjects
Risk ,Diabetes mellitus ,Hepatitis C virus ,Prevalence ,lcsh:QR1-502 ,virus diseases ,lcsh:RC109-216 ,digestive system diseases ,lcsh:Microbiology ,lcsh:Infectious and parasitic diseases - Abstract
The association of hepatitis C virus (HCV) infection with diabetes mellitus (DM) is a well documented topic. However, it has been debated whether HCV infection is the additional risk factor for the development of DM or it is an associated disease. To determine the prevalence of HCV infection and associated risk factors in diabetic patients, we investigated anti-HCV antibody in the 207 patients with DM (mean age: 58.9 ± 9.3, range 38-85) and 254 control subjects (mean age: 54.0 ± 9.7, range 40-81) by ELISA method, and risk factors for HCV infection in diabetic patients. Statistical analysis was performed by chi-square test, t-test and logistic regression analysis. Anti-HCV was found positive in 16 (7.7%) of diabetic cases and 5 (2.0%) of the control subjects. According to this result, a higher seroprevalence of HCV infection was observed in patients with type 2 DM (p= 0.003). We did not detect any difference between anti-HCV positive and negative patients with respect to age, sex, duration of diabetes, hospital admission, mode of therapy and known risk factors for HCV infection (p> 0.05) whereas mean ALT levels was higher in anti-HCV positive patients (p= 0.05). The results of this study suggest that HCV infection in the diabetic patients seems a trigger factor rather than to be an associated disease.
- Published
- 2003
49. Detection of Orchitis and Sacroiliitis due to Brucellosis by 99mTc Polyclonal Human Immunoglobulin Scintigraphy
- Author
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Rezan Bayraktar, Erhan Varoglu, Ayten Kadanali, and Hatice Uslu
- Subjects
Adult ,Male ,endocrine system ,Pathology ,medicine.medical_specialty ,Immunoglobulins ,Orchitis ,Brucella ,Scintigraphy ,Brucellosis ,Direct agglutination test ,medicine ,Humans ,Whole Body Imaging ,Radiology, Nuclear Medicine and imaging ,Sacroiliitis ,Radionuclide Imaging ,biology ,medicine.diagnostic_test ,business.industry ,Technetium ,General Medicine ,Epididymis ,medicine.disease ,biology.organism_classification ,medicine.anatomical_structure ,Polyclonal antibodies ,biology.protein ,business - Abstract
Here, we report 1 case of Brucella orchitis detected by 99mTc human immunoglobulin scintigraphy and confirmed by testicular ultrasound. A 29-year-old farmer was admitted to our hospital with fever, fatigue, arthralgia, and painful scrotal swelling that had appeared 12 days before admission. Clinically, right sacroiliitis was recorded through the Fabere test Unilateral sacroiliitis and orchitis were detected by 99mTc human immunoglobulin scintigraphy. Hypoechoic left testicular lesions and swelling of the concurrent epididymis were seen on a testicular ultrasound examination. Wright agglutination test and blood specimen culture for Brucella species were positive.
- Published
- 2012
50. Seroprevalance of Hepatitis B, Hepatitis C, Human Immunodeficiency Virus and Syphilis Infections in Blood Donors
- Author
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Gül KARAGÖZ, Ayten KADANALI, Mehmet Fatih BEKTAŞOĞLU, Behiye DEDE, and Sevda BABACAN ALTUĞ
- Subjects
lcsh:Internal medicine ,seroprevalance ,lcsh:R ,syphilis ,virus diseases ,HIV ,lcsh:Medicine ,lcsh:RC109-216 ,blood donor ,Hepatitis B ,lcsh:RC31-1245 ,Hepatitis C ,lcsh:Infectious and parasitic diseases - Abstract
Objective:In this retrospective study we aimed to determine the prevalance of Hepatitis B, Hepatitis C, Human Immunodeficiency Virus Infections and Syphilis in blood donors between January 2009 and July 2011.Materials and Methods:HbsAg, Anti-HCV, Anti-HIV 1-2 and VDRL screening tests were examined by ELISA in 10568 blood donors aged between 18 and 64. The distrubution of results were evulated according to year, age, and gender.Results:HBsAg was positive in 144 (1.4%), anti-HCV in 17 (0.2%), anti-HIV in 3 (0.03) and VDRL in 71 (0.7%) of the patients during the study.Conclusion:In conclusions, the results were similar to that reported in recent studies in Turkiye.
- Published
- 2012
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