2,758 results on '"water intoxication"'
Search Results
2. Contributing Factors to Local Bioimpedance Spectroscopy (COBI)
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Oslo University Hospital
- Published
- 2024
3. Detecting Fluid Accumulation With a Wearable Bioimpedance Sensor (DELOS)
- Author
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Oslo University Hospital
- Published
- 2024
4. Effects of ingesting beverages containing glycerol and sodium with isomaltulose or sucrose on fluid retention in young adults: a single-blind, randomized crossover trial.
- Author
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Otsuka, Junto, Okamoto, Yumi, Enoki, Yasuaki, Maejima, Daisuke, Fujii, Naoto, Kenny, Glen P., Mündel, Toby, Cotter, James D., and Amano, Tatsuro
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DRINKING (Physiology) , *RESEARCH funding , *GLYCERIN , *EDEMA , *STATISTICAL sampling , *RANDOMIZED controlled trials , *WATER intoxication , *CROSSOVER trials , *SODIUM , *DISACCHARIDES , *WATER-electrolyte balance (Physiology) , *BLOOD plasma , *BLOOD volume , *COMPARATIVE studies , *BEVERAGES - Abstract
We evaluated changes in hyperhydration and beverage hydration index (BHI, a composite measure of fluid balance after consuming a test beverage relative to water) during resting, induced by the consumption of beverages containing glycerol and sodium supplemented with fast-absorbing sucrose or slow-absorbing isomaltulose. In a randomized crossover, single-blinded protocol (clinical trials registry: UMIN000042644), 14 young physically active adults (three women) consumed 1 L of beverage containing either 7% glycerol + 0.5% sodium (Gly + Na), Gly + Na plus 7% sucrose (Gly + Na + Suc), Gly + Na plus 7% isomaltulose (Gly + Na + Iso), or water (CON) over a 40 min period. We assessed the change in plasma volume (ΔPV), BHI (calculated from cumulative urine output following consumption of water relative to that of the beverage), and blood glucose and sodium for 180 min after initiating ingestion. Total urine volume was reduced in all beverages containing glycerol and sodium compared to CON (all P ≤ 0.002). The addition of isomaltulose increased BHI by ∼45% (3.43 ± 1.0 vs. 2.50 ± 0.7 for Gly + Na, P = 0.011) whereas sucrose did not (2.6 ± 0.6, P = 0.826). The PV expansion was earliest for Gly + Na (30 min), slower for Gly + Na + Suc (90 min), and slowest for Gly + Na + Iso (120 min) with a concomitant lag in the increase of blood glucose and sodium concentrations. Supplementation of beverages containing glycerol and sodium with isomaltulose but not sucrose enhances BHI from those of glycerol and sodium only under a resting state, likely due to the slow absorption of isomaltulose-derived monosaccharides (i.e., glucose and fructose). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
- Published
- 2023
6. Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection (HIKO-STEC)
- Author
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National Institute of Allergy and Infectious Diseases (NIAID), Children's Hospital Medical Center, Cincinnati, Washington University School of Medicine, University of Utah, Seattle Children's Hospital, University of Colorado, Denver, Emory University, University of California, Davis, Baylor College of Medicine, Indiana University School of Medicine, University of Alabama at Birmingham, Arkansas Children's Hospital Research Institute, Children's National Research Institute, Children's Hospitals and Clinics of Minnesota, Medical University of South Carolina, University of Louisville, University of Oklahoma, Oregon Health and Science University, University of California, San Diego, McMaster University, The Hospital for Sick Children, University of Alberta, University of Kentucky, Case Western Reserve University, Nationwide Children's Hospital, and Vanderbilt University Medical Center
- Published
- 2023
7. Water insecurity among seasonal agriculture workers: perspectives from Spanish professionals
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Luis Alejandro Rodríguez-Guerrero, Iratxe Pérez-Urdiales, Astrid Escrig-Piñol, María del Mar Jiménez-Lasserrotte, María del Mar Pastor-Bravo, José Tomás Mateos, and Erica Briones-Vozmediano
- Subjects
Transients and migrants ,Agricultural workers’ diseases ,Water intoxication ,COVID-19 ,Qualitative research ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Migrant seasonal agricultural workers face conditions of material vulnerability such as inadequate housing difficulties prevent access to running water supplies. The purpose of this study is to explore the perceptions of professionals involved in the care and support of seasonal migrant agricultural workers, as it relates to water access and water consumption and their impact on these workers’ health, in a context of COVID-19 pandemic. Methods: A qualitative exploratory and descriptive study was conducted in 2021 as part of a larger research project, based on 63 personal semi-structured interviews with professionals who provided support to seasonal migrant agricultural workers in three Spanish autonomous regions. COREQ checklist was used for reporting. The interviews were recorded, transcribed, and imported into ATLAS.ti-9 for an inductive thematic analysis. Results: The results have been structured into two main themes: (1) Accessing and obtaining water; and (2) Health problems related to water consumption. Seasonal migrant agricultural workers experience barriers to obtaining safe water for hygiene, cleaning, food preparation and drinking. The implementation of regulations to reduce COVID-19 transmission resulted in improved hygiene levels in the migrants’ quarters, including access to safe drinking water. Conclusion: This study suggests that water insecurity experienced by migrant seasonal agricultural workers in Spain results from their poor living conditions and causes health problems related to a lack of hygiene and the use of unsafe water. Sustainable solutions are needed beyond the pandemic in order to provide migrant workers with adequate living conditions and ensure their water needs are fulfilled.
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- 2024
- Full Text
- View/download PDF
8. DEEP WATER.
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HYDROTHERAPY ,DETOXIFICATION (Alternative medicine) ,ALKALOSIS ,OXIDATIVE stress ,WATER supply ,WATER intoxication ,BLOOD sugar ,WATER ,WATER in the body ,MINERAL waters - Abstract
The article discusses the discovery of a highly structured fourth phase of water, formally named exclusion-zone water, that appeared when regular water was placed in contact with extremely hydrophilic objects. It describes the imaging techniques used by bioengineering professor Gerald Pollack and his laboratory assistants to identify an alternating, lattice-type array of hexagonal sheets of oxygen and hydrogen atoms. It explains the implications of the discovery for human health and wellbeing.
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- 2024
9. Oxytocin: physiology, pharmacology, and clinical application for labor management.
- Author
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Hermesch, Amy C., Kernberg, Annessa S., Layoun, Vanessa R., and Caughey, Aaron B.
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CLINICAL medicine ,FETAL heart rate ,NEONATAL intensive care units ,OXYTOCIN ,PEPTIDE hormones ,FETAL distress ,CHORIOAMNIONITIS - Abstract
Oxytocin is a peptide hormone that plays a key role in regulating the female reproductive system, including during labor and lactation. It is produced primarily in the hypothalamus and secreted by the posterior pituitary gland. Oxytocin can also be administered as a medication to initiate or augment uterine contractions. To study the effectiveness and safety of oxytocin, previous studies have randomized patients to low- and high-dose oxytocin infusion protocols either alone or as part of an active management of labor strategy along with other interventions. These randomized trials demonstrated that active management of labor and high-dose oxytocin regimens can shorten the length of labor and reduce the incidence of clinical chorioamnionitis. The safety of high-dose oxytocin regimens is also supported by no associated differences in fetal heart rate abnormalities, postpartum hemorrhage, low Apgar scores, neonatal intensive care unit admissions, and umbilical artery acidemia. Most studies reported no differences in the cesarean delivery rates with active management of labor or high-dose oxytocin regimens, thereby further validating its safety. Oxytocin does not have a predictable dose response, thus the pharmacologic effects and the amplitude and frequency of uterine contractions are used as physiological parameters for oxytocin infusion titration to achieve adequate contractions at appropriate intervals. Used in error, oxytocin can cause patient harm, highlighting the importance of precise administration using infusion pumps, institutional safety checklists, and trained nursing staff to closely monitor uterine activity and fetal heart rate changes. In this review, we summarize the physiology, pharmacology, infusion regimens, and associated risks of oxytocin. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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10. Water insecurity among seasonal agriculture workers: perspectives from Spanish professionals.
- Author
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Rodríguez-Guerrero, Luis Alejandro, Pérez-Urdiales, Iratxe, Escrig-Piñol, Astrid, Jiménez-Lasserrotte, María del Mar, Pastor-Bravo, María del Mar, Mateos, José Tomás, and Briones-Vozmediano, Erica
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PREVENTION of infectious disease transmission , *OCCUPATIONAL disease prevention , *RESEARCH , *HOUSEKEEPING , *NOMADS , *SOCIAL support , *COVID-19 , *WATER intoxication , *ATTITUDES of medical personnel , *RESEARCH methodology , *GOVERNMENT regulation , *HEALTH status indicators , *INTERVIEWING , *HYGIENE , *COOKING , *SEASONS , *QUALITATIVE research , *QUALITY of life , *RESEARCH funding , *WATER security , *THEMATIC analysis , *AGRICULTURAL laborers , *COVID-19 pandemic - Abstract
Background: Migrant seasonal agricultural workers face conditions of material vulnerability such as inadequate housing difficulties prevent access to running water supplies. The purpose of this study is to explore the perceptions of professionals involved in the care and support of seasonal migrant agricultural workers, as it relates to water access and water consumption and their impact on these workers' health, in a context of COVID-19 pandemic. Methods: A qualitative exploratory and descriptive study was conducted in 2021 as part of a larger research project, based on 63 personal semi-structured interviews with professionals who provided support to seasonal migrant agricultural workers in three Spanish autonomous regions. COREQ checklist was used for reporting. The interviews were recorded, transcribed, and imported into ATLAS.ti-9 for an inductive thematic analysis. Results: The results have been structured into two main themes: (1) Accessing and obtaining water; and (2) Health problems related to water consumption. Seasonal migrant agricultural workers experience barriers to obtaining safe water for hygiene, cleaning, food preparation and drinking. The implementation of regulations to reduce COVID-19 transmission resulted in improved hygiene levels in the migrants' quarters, including access to safe drinking water. Conclusion: This study suggests that water insecurity experienced by migrant seasonal agricultural workers in Spain results from their poor living conditions and causes health problems related to a lack of hygiene and the use of unsafe water. Sustainable solutions are needed beyond the pandemic in order to provide migrant workers with adequate living conditions and ensure their water needs are fulfilled. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Hyponatremia: Nursing Care across the Spectrum from Mild to Severe.
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Bartzak, Patricia J.
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COGNITION disorders , *HOMEOSTASIS , *ENURESIS , *NURSING , *WATER intoxication , *HYPERGLYCEMIA , *HOSPITAL patients , *HYPONATREMIA , *DEHYDRATION , *ROOMS , *VASOPRESSIN , *FAILURE to thrive syndrome , *OLD age - Abstract
Medical-surgical nurses must be aware of hyponatremia in patients and the potential for progression to severe hyponatremia (central pontine myelinolysis). Nurses should track serum sodium to be aware of mental status changes as hyponatremia develops and the spectrum of hyponatremia that can progress to pontine injury. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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12. The Effect of Pre-Exercise Hyperhydration on Exercise Performance, Physiological Outcomes and Gastrointestinal Symptoms: A Systematic Review.
- Author
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Jardine, William T., Aisbett, Brad, Kelly, Monica K., Burke, Louise M., Ross, Megan L., Condo, Dominique, Périard, Julien D., and Carr, Amelia J.
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WATER intoxication , *MEDICAL information storage & retrieval systems , *WATER-electrolyte balance (Physiology) , *SYSTEMATIC reviews , *GASTROINTESTINAL diseases , *SPORTS , *COMPARATIVE studies , *DESCRIPTIVE statistics , *ATHLETIC ability , *MEDLINE , *INFORMATION storage & retrieval systems , *DISEASE complications , *SYMPTOMS - Abstract
Background: Fluid loss during prolonged exercise in hot conditions poses thermoregulatory and cardiovascular challenges for athletes that can lead to impaired performance. Pre-exercise hyperhydration using nutritional aids is a strategy that may prevent or delay the adverse effects of dehydration and attenuate the impact of heat stress on exercise performance. Objectives: The aim of this systematic review was to examine the current literature to determine the effect of pre-exercise hyperhydration on performance, key physiological responses and gastrointestinal symptoms. Methods: English language, full-text articles that compared the intervention with a baseline or placebo condition were included. An electronic search of Medline Complete, SPORTDiscus and Embase were used to identify articles with the final search conducted on 11 October 2022. Studies were assessed using the American Dietetic Association Quality Criteria Checklist. Results: Thirty-eight studies involving 403 participants (n = 361 males) were included in this review (n = 22 assessed exercise performance or capacity). Two studies reported an improvement in time-trial performance (range 5.7–11.4%), three studies reported an improvement in total work completed (kJ) (range 4–5%) and five studies reported an increase in exercise capacity (range 14.3–26.2%). During constant work rate exercise, nine studies observed a reduced mean heart rate (range 3–11 beats min−1), and eight studies reported a reduced mean core temperature (range 0.1–0.8 °C). Ten studies reported an increase in plasma volume (range 3.5–12.6%) compared with a control. Gastrointestinal symptoms were reported in 26 studies, with differences in severity potentially associated with factors within the ingestion protocol of each study (e.g. treatment, dose, ingestion rate). Conclusions: Pre-exercise hyperhydration may improve exercise capacity during constant work rate exercise due to a reduced heart rate and core temperature, stemming from an acute increase in plasma volume. The combination of different osmotic aids (e.g. glycerol and sodium) may enhance fluid retention and this area should continue to be explored. Future research should utilise valid and reliable methods of assessing gastrointestinal symptoms. Furthermore, studies should investigate the effect of hyperhydration on different exercise modalities whilst implementing a strong level of blinding. Finally, females are vastly underrepresented, and this remains a key area of interest in this area. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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13. Electrolyte Disturbances
- Author
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Swan, Tricia B., Martinez, Carmen J., Zeretzke-Bien, Cristina M., editor, and Swan, Tricia B., editor
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- 2023
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14. Effect of Oral Nutritional Supplementation Combined With Impedance Vectors
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Indiana University School of Medicine, Ball State University, and Iris del Carmen Nieves Anaya, Principal Investigator
- Published
- 2022
15. Hyponatriämie: Ätiologie, Diagnostik und Akuttherapie.
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Perschinka, Fabian, Köglberger, Paul, Klein, Sebastian J., and Joannidis, Michael
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VASOPRESSIN ,WATER-electrolyte imbalances ,HYPONATREMIA ,BLOOD testing ,DRUG abuse ,URINALYSIS ,INAPPROPRIATE ADH syndrome - Abstract
Copyright of Medizinische Klinik: Intensivmedizin & Notfallmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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16. The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration (AMPlify)
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AMP Human; Park City, UT, United States Department of Defense, and Douglas J Casa, Principal Investigator
- Published
- 2021
17. Seizure from water intoxication following bowel preparation: a case report
- Author
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Ting-Hsuan Chiang, Jui-Hsiang Tan, Chun-Chao Chang, and Kuan-Chieh Fang
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Hyponatremia ,Colonoscopy ,Desmopressin ,Bowel preparation ,Water intoxication ,Case report ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Bowel preparation prior to colonoscopic examination is generally considered a safe process. Hyponatremia is a complication that has been reported in literature during bowel preparation. Individuals who develop severe symptomatic hyponatremia are often older and have comorbidities such as hypothyroidism, chronic kidney disease, or adrenal insufficiency. However, other mechanisms and circumstances can also lead to this potentially fatal complication. Case presentation We present a unique case of a patient who developed seizure prior to colonoscopy due to acute hyponatremia without any well-known risk factors. With the subsequent diagnosis of water intoxication, the use of desmopressin was believed to have contributed to this serious complication. Conclusion In addition to the use of certain well-documented medications and the presence of comorbidities that can lead to hyponatremia, clinicians should also be aware of the use of desmopressin as an important risk factor. Thorough history taking can guide individualized bowel preparation regimens to minimize the risk of undesired complications.
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- 2022
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18. Assessment of Volume Status in Chronic Hemodialysis: Comparison of Lung Ultrasound to Clinical Practice and Bioimpedance.
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Vareesangthip, Kornchanok, Thanapattaraborisuth, Banthita, Chanchairujira, Kullanuch, Wonglaksanapimon, Suwimon, and Chanchairujira, Thawee
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HEMODIALYSIS ,PULMONARY edema ,ULTRASONIC imaging ,LUNGS ,CRACKLES (Respiration) ,WATER intoxication ,HEMODIALYSIS complications - Abstract
Objective: Lung ultrasonography (LUS) has recently been used to evaluate extravascular lung water, and shown to be able to predict all-cause mortality in hemodialysis (HD) patients. This study aim to compare LUS with other volume assessment methods, and to verify the prognostic value of LUS in Thai chronic HD patients. Materials and Methods: We conducted a prospective cohort study in 36 chronic HD patients. Volume status before the HD session was evaluated by physical examinations, bioimpedance analysis (BIA), and ultrasound lung comets (ULCs). Mortality and morbidities were recorded during a 1-year follow-up period. Results: The degree of lung fluid accumulation was assessed by summation of the number of ULCs, and was classified into 3 groups: mild-to-moderate (ULC<15-29), severe (ULC=30-59), and very severe (ULC=60) in 11.1%, 77.8%, and 11.1% of the patients, respectively. Either clinical edema or lung crackle had low sensitivity (20-32%) to detect extravascular lung water excess in patient with mild-to-moderate ULC and severe ULC. Overhydration assessed by BIA was found in 75% and 64.3% of patients with mild-to-moderate and severe ULC, respecively. In patients with very severe ULC, the admission rate due to volume overload was significantly higher, there was also a trend of increased mortality, as well as intradialytic complications. Conclusion: Clinical assessment and BIA have limited value in determining extravascular fluid excess in the lung. Lung ultrasound is a useful tool to detect subclinical pulmonary congestion. The long-term outcome by using LUSguided fluid management needs larger population studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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19. Hyperhydration-Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes in Doping Control Analysis.
- Author
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Athanasiadou, Ioanna, Voss, Sven Christian, El Saftawy, Wesal, Al-Jaber, Hind, Dbes, Najib, Al-Yazedi, Sameera, Samsam, Waseem, Mohamed-Ali, Vidya, Alsayrafi, Mohammed, Valsami, Georgia, and Georgakopoulos, Costas
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PREVENTION of doping in sports , *LUTEINIZING hormone , *WATER intoxication , *WHITE people , *SPORTS drinks - Abstract
Low urinary luteinizing hormone (LH) values have been discussed as a marker to detect steroid abuse. However, suppressed LH concentrations related to highly diluted urine samples could be a misleading indication of anabolic steroid abuse. One aim of the present study was to examine the effect of hyperhydration on the interpretation of LH findings during doping control analysis and to investigate different possibilities to correct volume-related changes in urinary LH concentrations. Seven healthy, physically active, nonsmoking White males were examined for a 72-hr period, using water and a commercial sports drink as hyperhydration agents (20 ml/kg body weight). Urine samples were collected and analyzed according to the World Anti-Doping Agency's technical documents. Baseline urinary LH concentrations, expressed as the mean ± SD for each individual, were within the acceptable physiological range (7.11 ± 5.42 IU/L). A comparison of the measured LH values for both hyperhydration phases (Phase A: 4.24 ± 5.60 IU/L and Phase B: 4.74 ± 4.72 IU/L) with the baseline ("normal") values showed significant differences (Phase A: p < .001 and Phase B: p < .001), suggesting the clear effect of urine dilution due to hyperhydration. However, an adjustment of urinary LH concentrations by specific gravity based on a reference value of 1.020 seems to adequately correct the hyperhydration-induced decrease on the LH levels. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
20. Seizure from water intoxication following bowel preparation: a case report.
- Author
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Chiang, Ting-Hsuan, Tan, Jui-Hsiang, Chang, Chun-Chao, and Fang, Kuan-Chieh
- Subjects
HYPONATREMIA ,CHRONIC kidney failure ,DESMOPRESSIN ,ADRENAL insufficiency ,SEIZURES (Medicine) - Abstract
Background: Bowel preparation prior to colonoscopic examination is generally considered a safe process. Hyponatremia is a complication that has been reported in literature during bowel preparation. Individuals who develop severe symptomatic hyponatremia are often older and have comorbidities such as hypothyroidism, chronic kidney disease, or adrenal insufficiency. However, other mechanisms and circumstances can also lead to this potentially fatal complication. Case presentation: We present a unique case of a patient who developed seizure prior to colonoscopy due to acute hyponatremia without any well-known risk factors. With the subsequent diagnosis of water intoxication, the use of desmopressin was believed to have contributed to this serious complication. Conclusion: In addition to the use of certain well-documented medications and the presence of comorbidities that can lead to hyponatremia, clinicians should also be aware of the use of desmopressin as an important risk factor. Thorough history taking can guide individualized bowel preparation regimens to minimize the risk of undesired complications. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
21. Pediatric Exposures to Toxic Substances in the Home.
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HOME environment , *POISONING , *WATER intoxication , *HAZARDOUS substances , *CONTINUING education units , *HYDROCARBONS , *FOREIGN bodies , *TOBACCO products , *ENVIRONMENTAL exposure , *THERAPEUTICS , *SYMPTOMS , *CHILDREN - Published
- 2022
22. Expérience monocentrique du système RenalGuard® pour limiter l'insuffisance rénale aiguë post-contraste après une procédure coronaire interventionnelle chez des patients à haut risque.
- Author
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Elleuch, Ahmed, Hebbo, Amjad, Steinecker, Matthieu, Bouaouina, Mehdi Saighi, Alqudwa, Ashraf, Ghannem, Mohamed, Poulos, Nabil, and Aubry, Pierre
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CHRONIC kidney failure , *DIURESIS , *INTRAVENOUS therapy , *WATER intoxication , *GLOMERULAR filtration rate - Abstract
Despite an often favorable risk/benefit ratio, patients with severe chronic kidney disease are sometimes declined for interventional coronary procedures, due to the risk of acute kidney injury post-contrast (AKI-PC). A large preventive supply of intravenous fluid may be problematic in this population. The RenalGuard® system allows hyperhydration by maintaining a stable volemia through an enhanced diuresis. This work reports the evaluation of the RenalGuard® system in 25 consecutive patients with chronic kidney disease (glomerular filtration rate < 40 mL/min/1.73 m²) requiring an interventional coronary procedure (coronary angiography and/or percutaneous coronary intervention) and at high risk of IRA-PC. An increase in serum creatinine ≥ 26.5 µmol/L at 48–72 hours (AKI-PC definition) was observed in 4 patients (16%). The mean glomerular filtration rate was 26 ± 8 mL/min/1.73 m² at 48–72 hours versus 25 ± 8 mL/min/1.73 m² at baseline. No patient presented with an increase in serum creatinine ≥ 1.5 from baseline, stage 2 or 3 AKI, or acute pulmonary edema. No renal replacement therapy was necessary. One death unrelated to AKI-PC occurred during hospital stay. This single-center observational study suggests that the RenalGuard® system, allowing diuresis-adjusted hyperhydration, is safe and useful for patients at high risk of AKI-PC after an interventional coronary procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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23. AQP4-A25Q Point Mutation in Mice Depolymerizes Orthogonal Arrays of Particles and Decreases Polarized Expression of AQP4 Protein in Astrocytic Endfeet at the Blood–Brain Barrier.
- Author
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Dan-Dan Zhu, Guang Yang, Yue-Lin Huang, Ting Zhang, Ao-Ran Sui, Na Li, Wei-Heng Su, Hai-Lun Sun, Jing-Jing Gao, Michael Ntim, Rong-Xiao Guan, Ling-Ling Jin, Jian Yu, Zhi-Yong Huang, Tong-Hui Ma, and Shao Li
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ORTHOGONAL arrays , *PROTEIN expression , *POLYACRYLAMIDE gel electrophoresis , *CEREBRAL edema , *POINT mutation (Biology) , *BRAIN injuries , *BLOOD-brain barrier - Abstract
Aquaporin-4 (AQP4) is characterized by the formation of orthogonal arrays of particles (OAPs) comprising its M1 and M23 isoforms in the plasma membrane. However, the biological importance of OAP formation is obscure. Here, we developed an OAP depolymerization male mouse model by transgenic knock-in of an AQP4-A25Q mutation. Analyses of the mutant brain tissue using blue native polyacrylamide gel electrophoresis, super-resolution imaging, and immunogold electron microscopy revealed remarkably reduced OAP structures and glial endfeet localization of the AQP4-A25Q mutant protein without effects on its overall mRNA and protein expression. AQP4A25Q/A25Q mice showed better survival and neurologic deficit scores when cerebral edema was induced by water intoxication or middle cerebral artery occlusion/reperfusion. The brain water content and swelling of pericapillary astrocytic endfeet processes in AQP4A25Q/A25Q mice were significantly reduced, functionally supporting decreased AQP4 protein expression at the blood–brain barrier. The infarct volume and neuronal damage were also reduced in AQP4A25Q/A25Q mice in the middle cerebral artery occlusion/reperfusion model. Astrocyte activation in the brain was alleviated in AQP4A25Q/A25Q mice, which may be associated with decreased cell swelling. We conclude that the OAP structure of AQP4 plays a key role in its polarized expression in astrocytic endfeet processes at the blood–brain barrier. Therefore, our study provided new insights into intervention of cerebral cellular edema caused by stroke and traumatic brain injury through regulating AQP4 OAP formation. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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24. Acute water intoxication in hysteroscopic myomectomy: a rare case report
- Author
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Chen, Yanchang, Zhao, Shuquan, Tang, Weilong, Li, Zhiyan, Xie, Jianjie, and Luo, Bin
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- 2023
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25. Handgrip Strength, Overhydration and Nutritional Status as a Predictors of Gastrointestinal Toxicity in Cervical Cancer Patients. A Prospective Study.
- Author
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Laura, Flores-Cisneros, Lucely, Cetina-Pérez, Tatiana, Galicia-Carmona, Roberto, Jimenez-Lima, Dulce, González-Islas, Arturo, Parra-Solano, Maricarmen, Gómez-Guzman, and Lilia, Castillo-Martínez
- Subjects
- *
GRIP strength , *BODY composition , *WATER intoxication , *CONFIDENCE intervals , *CANCER chemotherapy , *GASTROINTESTINAL diseases , *SARCOPENIA , *CANCER patients , *COMPARATIVE studies , *RISK assessment , *TERMS & phrases , *MALNUTRITION , *DRUG toxicity , *NUTRITIONAL status , *LONGITUDINAL method , *DISEASE risk factors ,CERVIX uteri tumors - Abstract
Background: Antineoplastic treatments produce adverse events (AE) such as gastrointestinal toxicity. These AE can reduce nutritional intake and promote weight and muscle mass loss. Objective: To determine if body composition, nutritional status, or muscle function predicts gastrointestinal toxicity during chemotherapy in cervical cancer (CC) patients. Methods: Women with CC were studied. Nutritional status was evaluated according to PG-SGA, and body composition was measured with bioimpedance. Toxicity was graded according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE). Results: A total of 207 women, 81 with toxicity and 126 without toxicity groups, were studied. Patients in the toxicity group had less handgrip strength (17.7 ± 5.0 vs. 20.3 ± 5.0 p = 0.0004); phase angle (5.2 ± 1.1 vs. 5.9 ± 1.0, p = 0.0065); higher prevalence of sarcopenia (35.9% vs. 20.6%, p = 0.016); overhydration (25.9% vs. 6.3% p < 0.001); and PG-SGA C (14.1% vs. 4.0%, p < 0.001) when compared to patients without toxicity. Handgrip strength (HR: 0.93, 95% CI 0.88–0.98, p = 0.028), overhydration (HR: 2.82, 95% CI 1.22–6.51, p = 0.015) and been severely malnourished according to PG-PGA (HR: 3.6, 95%CI 1.46–9.2, p < 0.001) were associated with the risk to present gastrointestinal toxicity. Conclusion: handgrip strength, overhydration, and severe malnutrition are independent risk factors to the presence of gastrointestinal toxicity in CC patients [ABSTRACT FROM AUTHOR]
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- 2022
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26. mysterious death of the beer drinking champ: potential role for hyperacute water loading and acute hyponatremia.
- Author
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Perez-Gomez, Maria Vanessa, Sanchez-Ospina, Didier, Tejedor, Alberto, and Ortiz, Alberto
- Abstract
Hyponatremia is acute when present for <48 h. Most cases of acute hyponatremia involve both excess free water intake and an at least partial urinary free water excretion defect. By contrast, hyperacute water intoxication may result from a large excess electrolyte-free water intake in such a short time that properly working urinary free water excretion mechanisms cannot cope. A hyperacute decrease in serum sodium may lead to death before medical intervention takes place. Well-documented cases have been published in the military medicine literature. In addition, news reports suggest the existence of cases of voluntary ingestion of excess free water by non-psychiatric individuals usually during 'dare' activities. Education of the public is required to prevent harm from these high-risk activities. Adequate training of emergency medical units may prevent lethal outcomes. Spanish media reported the case of a male who died following his triumph in a 20-min beer drinking contest. 'From a heart attack. Man dies after drinking six litres of beer in a contest' ran the news. We now review the physiology underlying hyperacute water intoxication and discuss the potential contribution of hyperacute water loading and acute hyponatremia to the demise of this patient. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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27. Study Findings from Far Eastern Memorial Hospital Provide New Insights into Water Intoxication (Predictors of Infused Distending Fluid Volume in Hysteroscopic Myomectomy).
- Published
- 2024
28. Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx) (SASinTx)
- Author
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Adam Ogna, Centre d'Investigation et Recherche sur le Sommeil (CIRS)
- Published
- 2018
29. Case Report: A Patient With Neuroleptic Malignant Syndrome, Water Intoxication and Hyponatremia Associated With Severe Cerebral Edema and Coma.
- Author
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Takenouchi, Haruka, Anno, Takatoshi, Kimura, Yukiko, Kawasaki, Fumiko, Shirai, Ryo, Kaneto, Hideaki, Kurokawa, Katsumi, and Tomoda, Koichi
- Subjects
CEREBRAL edema ,NEUROLEPTIC malignant syndrome ,HYPONATREMIA ,VASOPRESSIN ,INAPPROPRIATE ADH syndrome ,COMA - Abstract
Background: Water intoxication is typically caused by primary or psychogenic polydipsia that potentially may lead to fatal disturbance in brain functions. Neuroleptic malignant syndrome (NMS) is a serious complication induced by administration of antipsychotics and other psychotropic drugs. The combination of inappropriate secretion of antidiuretic hormone (SIDAH), NMS and rhabdomyolysis have been rarely reported. Our patient also developed severe water intoxication. Case presentation: Herein we report a comatose case of NMS complicated with water intoxication, syndrome of SIADH and rhabdomyolysis. This patient had severe cerebral edema and hyponatremia that were improved rapidly by the correction of hyponatremia within a couple of days. Conclusions: Malignant neuroleptic syndrome water intoxication, SIADH and rhabdomyolysis can occur simultaneously. Comatose conditions induced by cerebral edema and hyponatremia can be successfully treated by meticulous fluid management and the correction of hyponatremia. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
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30. Case Report: A Patient With Neuroleptic Malignant Syndrome, Water Intoxication and Hyponatremia Associated With Severe Cerebral Edema and Coma
- Author
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Haruka Takenouchi, Takatoshi Anno, Yukiko Kimura, Fumiko Kawasaki, Ryo Shirai, Hideaki Kaneto, Katsumi Kurokawa, and Koichi Tomoda
- Subjects
severe cerebral edema ,hyponatremia ,neuroleptic malignant syndrome ,water intoxication ,syndrome of inappropriate secretion of antidiuretic hormone ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundWater intoxication is typically caused by primary or psychogenic polydipsia that potentially may lead to fatal disturbance in brain functions. Neuroleptic malignant syndrome (NMS) is a serious complication induced by administration of antipsychotics and other psychotropic drugs. The combination of inappropriate secretion of antidiuretic hormone (SIDAH), NMS and rhabdomyolysis have been rarely reported. Our patient also developed severe water intoxication.Case presentationHerein we report a comatose case of NMS complicated with water intoxication, syndrome of SIADH and rhabdomyolysis. This patient had severe cerebral edema and hyponatremia that were improved rapidly by the correction of hyponatremia within a couple of days.ConclusionsMalignant neuroleptic syndrome water intoxication, SIADH and rhabdomyolysis can occur simultaneously. Comatose conditions induced by cerebral edema and hyponatremia can be successfully treated by meticulous fluid management and the correction of hyponatremia.
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- 2022
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31. Effect of Methylprednisolone on Experimental Brain Edema in Rats – Own Experience Reviewed.
- Author
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KOZLER, Petr, MAREŠOVÁ, Dana, and POKORNÝ, Jaroslav
- Subjects
METHYLPREDNISOLONE ,WATER intoxication ,BLOOD-brain barrier ,NEURONS ,INTRAPERITONEAL injections ,INTRACRANIAL pressure ,RATS ,NEUROPROTECTIVE agents ,BRAIN injuries ,CEREBRAL edema ,DISEASE complications - Abstract
Brain edema – a frequently fatal pathological state in which brain volume increases resulting in intracranial pressure elevation – can result from almost any insult to the brain, including traumatic brain injury. For many years, the objective of experimental studies was to find a method to prevent the development of brain edema at the onset. From this perspective, the use of methylprednisolone (MP) appears promising. High molecular MP (MW>50 kDa) can be incorporated into the brain – in the conditions of the experimental model – either by osmotic bloodbrain barrier disruption (BBBd) or during the induction of cellular edema by water intoxication (WI) – a condition that increases the BBB permeability. The time window for administration of the MP should be at the earliest stages of edema. The neuroprotective effect of MP on the permeability of cytoplasmatic membranes of neuronal populations was proved. MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
32. Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization.
- Author
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Hellas, Julia A. and Andrew, R. David
- Subjects
- *
DRINKING (Physiology) , *SPREADING cortical depression , *EDEMA , *CEREBRAL ischemia , *BRAIN injuries , *INAPPROPRIATE ADH syndrome , *BLOOD flow - Abstract
An acute reduction in plasma osmolality causes rapid uptake of water by astrocytes but not by neurons, whereas both cell types swell as a consequence of lost blood flow (ischemia). Either hypoosmolality or ischemia can displace the brain downwards, potentially causing death. However, these disorders are fundamentally different at the cellular level. Astrocytes osmotically swell or shrink because they express functional water channels (aquaporins), whereas neurons lack functional aquaporins and thus maintain their volume. Yet both neurons and astrocytes immediately swell when blood flow to the brain is compromised (cytotoxic edema) as following stroke onset, sudden cardiac arrest, or traumatic brain injury. In each situation, neuronal swelling is the direct result of spreading depolarization (SD) generated when the ATP-dependent sodium/potassium ATPase (the Na+/K+ pump) is compromised. The simple, and incorrect, textbook explanation for neuronal swelling is that increased Na+ influx passively draws Cl− into the cell, with water following by osmosis via some unknown conduit. We first review the strong evidence that mammalian neurons resist volume change during acute osmotic stress. We then contrast this with their dramatic swelling during ischemia. Counter-intuitively, recent research argues that ischemic swelling of neurons is non-osmotic, involving ion/water cotransporters as well as at least one known amino acid water pump. While incompletely understood, these mechanisms argue against the dogma that neuronal swelling involves water uptake driven by an osmotic gradient with aquaporins as the conduit. Promoting clinical recovery from neuronal cytotoxic edema evoked by spreading depolarizations requires a far better understanding of molecular water pumps and ion/water cotransporters that act to rebalance water shifts during brain ischemia. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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33. Posterior Reversible Encephalopathy Syndrome Due to Acute Water Intoxication in a Patient with Schizophrenia
- Author
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Takaoka Y, Akaho R, Inada K, Muraoka H, Hokama C, Inoue A, and Nishimura K
- Subjects
posterior reversible encephalopathy ,schizophrenia ,water intoxication ,Medicine (General) ,R5-920 - Abstract
Yohei Takaoka,1,2 Rie Akaho,1 Ken Inada,1 Hiroyuki Muraoka,1 Choryo Hokama,1 Atsuko Inoue,1 Katsuji Nishimura1 1Department of Psychiatry, Tokyo Women’s Medical University, Tokyo, Japan; 2Department of Psychiatry, Kuki Suzunoki Hospital, Kuki, Saitama, JapanCorrespondence: Rie AkahoDepartment of Psychiatry, Tokyo Women’s Medical University, Tokyo, JapanEmail akaho.rie@twmu.ac.jpAbstract: Posterior reversible encephalopathy syndrome (PRES) is a clinical syndrome that presents as transient cerebral edema (vasogenic edema), usually on a background of hypertensive encephalopathy, puerperal eclampsia, or immunosuppressant drug use. We describe a case of PRES that arose in the context of a psychiatric disorder. The patient was a 26-year-old woman with schizophrenia who was hospitalized upon falling into a catatonic stupor and then suffered acute anxiety leading to impulsive polydipsia and subsequent water intoxication. She lost consciousness, and brain magnetic resonance imaging revealed a high density area, primarily affecting the cortex and subcortical white matter in areas in the occipital and parietal lobes, leading to the diagnosis. We did not treat the hyponatremia by means of aggressive sodium supplementation but rather balanced the extracellular fluid by continuous infusion of isotonic electrolyte replacement fluid. The patient’s level of consciousness improved gradually, but a total 141 days passed before hospital discharge was appropriate. The prognosis for PRES is generally favorable, but irreversible neurological damage can occur. We believe, therefore, that brain magnetic resonance imaging should be performed promptly whenever PRES is suspected and that timely, appropriate treatment is of utmost importance. If PRES is observed in a psychiatric patient, it is important to investigate whether the condition might have been caused by water intoxication and to treat the condition accordingly.Keywords: posterior reversible encephalopathy, schizophrenia, water intoxication
- Published
- 2020
34. A compulsive act of excess water intake leading to hyponatraemia and rhabdomyolysis: a case report
- Author
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Sudheera Fernando, Francisca Sivagnanam, and Devarajan Rathish
- Subjects
Water intoxication ,Hyponatraemia ,Hypokalaemia ,Rhabdomyolysis ,Ureteric calculus ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Primary polydipsia is commonly seen in patients with psychiatric illnesses. Excess water intake is also seen in patient with anorexia and anticholinergic medications. We report a patient who had hyponatraemia and rhabdomyolysis after consuming excess water for ureteric calculus. Case presentation A healthy middle-aged male presented with an episode of generalized tonic-clonic seizure and reduced level of consciousness preceded by consumption of excess water. He was recently diagnosed to have a ureteric calculus and was advised to consume plenty of water. On examination, he was disoriented in place, person and time. Except for the generalized diminished reflexes, other neurological and systemic examinations were normal. He had severe hyponatraemia, mild hypokalaemia and myoglobulinuria. His serum creatinine phosphokinase and aspartate aminotransferase were markedly elevated. The diagnosis of rhabdomyolysis in the setting of acute water intoxication was made. Optimum fluid and electrolyte management achieved a dramatic recovery of consciousness, hyponatraemia and rhabdomyolysis. Discussion The patient has had excess water intake due to a compulsive act in the background fear of ureteric calculus. Such act could lead to severe hyponatraemia and rhabdomyolysis. Therefore, future similar acts could be prevented by proper medical advice. Further, emergency physicians should be vigilant for rhabdomyolysis in patients with hyponatraemia or hypokalaemia.
- Published
- 2019
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35. Infantile Status Epilepticus: A Case of Excessive Water Intake in a Five-Month-Old Girl.
- Author
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Alshaikh A, Aldoseri AA, and Jadah RHS
- Abstract
Hyponatremia in children, especially in normal infants below the age of six months, is a common cause of the first onset of afebrile convulsions, which can be rarely associated with water intoxication and can lead to a state of encephalopathy and status epilepticus if not diagnosed and managed properly early. Water intoxication is an uncommon but potentially lethal cause of hyponatremia. We report a five-month-old girl who presented to our hospital with status epilepticus, facial puffiness, cyanosis, and severe hyponatremia secondary to water intoxication. Proper investigations and labs were done, and the patient was managed successfully. The aim of reporting this case is to highlight the importance of water intoxication with secondary status epilepticus in infants below six months of age., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Alshaikh et al.)
- Published
- 2024
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36. Severe Posterior Reversible Encephalopathy Syndrome Secondary to Hyponatremia in a Patient with Water Intoxication.
- Author
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Gonzaga Ferreira JM, Alves Pedrosa D, Matos BA, Marques RF, and Alquéres RA
- Abstract
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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37. Prise en charge de la pancréatite aiguë. Revue de la littérature.
- Author
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Guyot, A., Lequeu, J.B., Dransart-Rayé, O., Chevallier, O., Nguyen, M., Charles, P.E., Mouillot, T., Manfredi, S., and Degand, T.
- Subjects
- *
PANCREATITIS , *ANTICOAGULANTS , *WATER intoxication , *DISEASE management , *PREVENTIVE medicine - Abstract
La prise en charge de la pancréatite aiguë est maintenant assez codifiée, avec des recommandations précises élaborées par des groupes d'experts. Ces recommandations traitent notamment du bilan initial minimal, des scores de gravités reconnus, de la prise en charge médicale initiale avec l'hyperhydratation, l'anticoagulation préventive, la réalimentation précoce, des délais d'imagerie et de la gestion des complications. Nous avons essayé dans ce travail, de regrouper les différentes recommandations, articles et études traitant de ce sujet, en nous fondant plus particulièrement sur les recommandations européennes, afin de guider la prise en charge de la pancréatite aiguë en pratique courante. The management of acute pancreatitis is now fairly codified, with specific recommendations developed by expert groups. These recommendations deal in particular with the minimum initial assessment, recognized severity scores, initial medical management with hyperhydration, preventive anticoagulation, early refeeding, delays in imaging and management of complications. In this work, we have tried to bring together the various recommendations, articles and studies dealing with this subject, based more particularly on European recommendations, in order to guide the management of acute pancreatitis in current practice. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
38. The Hidden Cause of Acne : How Toxic Water Is Affecting Your Health and What You Can Do About It
- Author
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Melissa Gallico and Melissa Gallico
- Subjects
- Fluorides--Toxicology--Nutritional aspects, Skin--Care and hygiene, Fluorides--Toxicology--Health aspects, Acne--Alternative treatment, Water--Toxicology, Water intoxication
- Abstract
An investigation into the root cause of the modern acne epidemic--fluoride--and how to remove it from your diet and lifestyle for clear, healthy skin • Chronicles the existing acne research to reveal fluoride was behind the rise of teenage acne in the mid-20th century and the dramatic increase in adult acne today • Details how to avoid fluoridated foods and beverages as well as other common sources of fluoride, such as pesticides, pharmaceuticals, and household products • Explains how to displace fluoride stored in your bones and other tissues through nutrition and the careful use of iodine According to a recent study, over 20 percent of men and 35 percent of women experience acne after the age of 30. At the same time, remote indigenous societies--such as the Inuit before they “moved to town” in the 1960s--experience no acne at all, even among their teenagers. Many things have been cited as causing acne, from sugar, chocolate, or pizza to dirty pillowcases, hormones, or genetics, but none of these “causes” have been able to explain the majority of acne cases, nor why chronic acne is on the rise. Using her FBI intelligence analyst skills, Melissa Gallico identifies fluoride as the root cause of the modern acne epidemic. Chronicling the existing acne research, she reveals where each study went wrong and what they missed. She shares her personal 20-year struggle with severe cystic acne not only on her face, but on her neck, chest, back, and even inside her ears. She explains how her travels around the world and her intelligence work helped her pinpoint exactly what was causing her treatment-resistant flare-ups--fluoridated water, foods, dental products, and the systemic build-up of childhood fluoride treatments. She details how to avoid fluoridated foods and beverages and explains how sources of fluoride work their way deeply into our daily lives through water as well as fluoride-based pesticides, pharmaceuticals, and common household products. The author exposes the corrupt science used to convince people of fluoride's health benefits and examines the systemic toxicity of fluoride, including its anti-thyroid and neurotoxin effects, how it remains in the body for years, and how it can cause the symptoms of illnesses, such as arthritis, fibromyalgia, and depression. She explains how to displace fluoride stored in your bones and tissues through nutrition and the careful use of iodine. Offering a guide to freeing yourself from persistent adult acne, Gallico shows that it is possible to heal your skin even when dermatologists and their prescriptions have failed.
- Published
- 2018
39. Psychogenic polydipsia in intellectual disability – A clinical challenge
- Author
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M do Rosario Monteiro, D Pires, and A Norton
- Subjects
Primary Polydipsia ,Psychogenic Polydipsia ,Intellectual Disability ,Water Intoxication ,Antipsychotics ,Clozapine ,Psychology ,BF1-990 ,Psychiatry ,RC435-571 - Abstract
Introduction: Primary polydipsia (PP), or psychogenic polydipsia, is the excessive liquid intake (> 3 litres per day) that is not explained by any other medical condition. It can occur in up to 14% of psychia- tric patients and the origin of the water-seeking behaviour among these patients remains unknown. When uncontrolled, patients drink beyond their renal capacity of excretion, developing hyponatremia, which can progress to water intoxication with nausea, vomiting, confusion, ataxia and can even be fatal. Methods: Case presentation based on the observation of the patient in the inpatient unit, analytical studies and the patient’s cli- nical records. We present a non-systematic review of the literature on the possible mechanisms that may be at the origin of the primary polydipsia and treatment approaches that have been suggested. Case presentation: We present a case of an individual with an intellectual disability medicated with risperidone for several years suffering from primary polydipsia and consequent severe water in- toxication. After stopping risperidone and switching to low dose clo- zapine, the polydiptic behaviour stopped. One month after discharge it hadn’t resurged and the patient remained analytically normal. Discussion: Antipsychotics have been suggested to be asso- ciated with primary polydipsia due to their high affinity to dopamine D2 receptors with consequent receptor hypersensitivity in the hypo- thalamic-pituitary-adrenal axis and centre of thirst. Fluid restriction is important to correct hyponatremia. A pharmacological approach is often imperative to help patients to become more permeable to behavioural strategies. Unlike other antipsychotics, clozapine does not induce D2 hypersensitivity in the centre of thirst, therefore, it can be a reasonable treatment option. Conclusion: It is important to elucidate clinicians about this condition since it is common in psychiatric patients and often goes unnoticed or inadequately approached. Further investigations on the link between primary polydipsia and mental diseases are needed, as they are greatly under-researched, in order to find new treatments and management approaches to this condition.
- Published
- 2021
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40. Electrolyte Disturbances
- Author
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Swan, Tricia B., Zeretzke-Bien, Cristina M., editor, Swan, Tricia B., editor, and Allen, Brandon R., editor
- Published
- 2018
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41. Anesthesia for TURP
- Author
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Bah, Maimouna, Green, Michael Stuart, Goudra, Basavana G., editor, Duggan, Michael, editor, Chidambaran, Vidya, editor, Venkata, Hari Prasad Krovvidi, editor, Duggan, Elizabeth, editor, Powell, Mark, editor, and Singh, Preet Mohinder, editor
- Published
- 2018
- Full Text
- View/download PDF
42. Reports Outline Water Intoxication Study Findings from Kawasaki Medical School (Impacts of Age and Gender On Brain Edema In a Mouse Water Intoxication Model).
- Abstract
A study conducted at Kawasaki Medical School in Okayama, Japan, examined the impacts of age and gender on brain edema in a mouse water intoxication model. The researchers administered distilled water to mice and measured brain water content, as well as analyzed markers of brain damage. They found that the onset of brain edema differed by age and gender, and that suppressing brain edema was possible in aquaporin 4 knockout mice. The study concluded that this water intoxication model is effective for exploring new treatments for brain edema. [Extracted from the article]
- Published
- 2024
43. Reports from Kagawa University Advance Knowledge in Water Intoxication (Effects of d-allose on anti-brain edema effects and reduction of tumor necrosis factor-alpha and interleukin-6 in the water intoxication model).
- Abstract
A study conducted at Kagawa University in Miki, Japan, explored the effects of d-allose on brain edema and inflammatory cytokines in a water intoxication model. The researchers found that d-allose, a rare sugar with antioxidant properties, significantly reduced brain edema and inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6. These findings suggest that d-allose's antioxidant effect may have anti-inflammatory effects and reduce brain edema. The study provides valuable insights into the potential therapeutic applications of d-allose in brain diseases and conditions. [Extracted from the article]
- Published
- 2024
44. Usefulness of bioelectrical impedance analysis and ECW ratio as a guidance for fluid management in critically ill patients after operation.
- Author
-
Chung, Yoon Ji and Kim, Eun Young
- Subjects
- *
BIOELECTRIC impedance , *FLUIDS , *POSTOPERATIVE care , *WATER intoxication , *CLINICAL trials - Abstract
We determined the relationship between changes in bioelectrical impedance analysis (BIA) parameters and response of critically ill patients to fluid therapy during early postoperative period. Associations between BIA values indicating volume status of postoperative patient and clinical outcomes were also evaluated. From May 2019 to April 2020, patients who were admitted to the surgical intensive care unit (SICU) of our institution at more than 48 h after surgery were enrolled. Volume status was measured with a portable BIA device every morning for five days from SICU admission. Overhydration was defined as the case where extracellular water (ECW) ratio > 0.390 measured by BIA. Participants were daily classified into an overhydration or a normohydration group. The relationship between daily hydration status and postoperative outcome was evaluated. Most of the 190 participants showed the overhydration status in the first 48 h after surgery. The overhydration status on day 3 was significant predictor of postoperative morbidities (OR 1.182) and in-hospital mortality (OR 2.040). SOFA score was significant factor of postoperative morbidities (OR 1.163) and in-hospital mortality (OR 3.151) except for the overhydration status on day 3. Cut-off values of overhydration status by ECW ratio at day 3 for predicting postoperative morbidities and in-hospital mortality were > 0.3985 and > 0.4145, respectively. BIA would be a useful and convenient tool to assess the volume status of patients requiring intensive fluid resuscitation in early postoperative period. Overhydration status by ECW ratio on postoperative day 3 needs careful monitoring and appropriate interventions to improve clinical outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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45. Assessment of Fluid Status by Bioimpedance Analysis and Central Venous Pressure Measurement and Their Association with the Outcomes of Severe Acute Kidney Injury.
- Author
-
Karpavičiūtė, Justina, Skarupskienė, Inga, Balčiuvienė, Vilma, Vaičiūnienė, Rūta, Žiginskienė, Edita, and Bumblytė, Inga Arūnė
- Subjects
VENOUS pressure ,ACUTE kidney failure ,BIOELECTRIC impedance ,CRITICALLY ill ,WATER intoxication - Abstract
Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill patients with acute kidney injury (AKI). In this study, we intended to assess fluid status using bioimpedance analysis (BIA) and central venous pressure (CVP) measurement and to evaluate the association between hyperhydration and hypervolemia with the outcomes of severe AKI. Materials and Methods: A prospective study was conducted in the Hospital of the Lithuanian University of Health Sciences Kauno Klinikos. Forty-seven patients treated at the Intensive Care Unit (ICU) with severe AKI and a need for renal replacement therapy (RRT) were examined. The hydration level was evaluated according to the ratio of extracellular water to total body water (ECW/TBW) of bioimpedance analysis and volemia was measured according to CVP. All of the patients were tested before the first hemodialysis (HD) procedure. Hyperhydration was defined as ECW/TBW > 0.39 and hypervolemia as CVP > 12 cm H2O. Results: According to bioimpedance analysis, 72.3% (n = 34) of patients were hyperhydrated. According to CVP, only 51.1% (n = 24) of the patients were hypervolemic. Interestingly, 69.6% of hypovolemic/normovolemic patients were also hyperhydrated. Of all study patients, 57.4% (n = 27) died, in 29.8% (n = 14) the kidney function improved, and in 12.8% (n = 6) the demand for RRT remained after in-patient treatment. A tendency of higher mortality in hyperhydrated patients was observed, but no association between hypervolemia and outcomes of severe AKI was established. Conclusions: Three-fourths of the patients with severe AKI were hyperhydrated based on bioimpedance analysis. However, according to CVP, only half of these patients were hypervolemic. A tendency of higher mortality in hyperhydrated patients was observed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
46. Intraoperative water intoxication and hypothermia in a patient undergoing hysteroscopic submucosal fibroid resection
- Author
-
Nagalakshmi Palanisamy, Mamie Zachariah, and Nikitha Mani
- Subjects
hypothermia ,operative hysteroscopy ,water intoxication ,Medicine - Abstract
Hysteroscopy is a useful diagnostic tool as well as a treatment option in many of the gynecological procedures. Although hysteroscopic procedures are generally safe in expert hands, the clinicians can face complications during and after the procedure. One of the intraoperative complications is water intoxication during the procedure. The pathophysiology and treatment of this complication are similar to the TURP syndrome. Hypothermia due to the absorption of cold irrigation fluid is another complication we must be aware of. Vigilant monitoring and choice of regional anesthesia can help early detection and prevention of these complications.
- Published
- 2020
- Full Text
- View/download PDF
47. Severe hyponatremia due to water intoxication in a child with sickle cell disease: A case report.
- Author
-
Rossi, Roberta, Castagno, Emanuele, Matarazzo, Patrizia, Tuli, Gerdi, Saracco, Paola, Urbino, Antonio F., and Bondone, Claudia
- Subjects
- *
HYPONATREMIA , *WATER intoxication , *SICKLE cell anemia - Abstract
Water intoxication is a potentially fatal hypo-osmolar syndrome with brain function impairment. Isolated symptomatic excessive ingestion of free water is very rare in childhood. We report a case of acute hyponatremia due to water intoxication without Antidiuretic Hormone (ADH) excess in a child with sickle cell disease. The boy was admitted to our Emergency Department because of new-onset prolonged generalized seizures. Blood test showed hyponatremia, and elevated creatine kinase value; neuroimaging was negative. His recent medical history revealed that on the day before he had drunk about 4 liters of water in 2 hours to prevent sickling, because of back pain. He was treated with mild i.v. hydration with normal saline solution and showed progressive clinical improvement and normalization of laboratory test. Rhabdomyolysis is a rare complication of hyponatremia whose underlying mechanism is still unclear. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
48. Acute Dysnatremias - a dangerous and overlooked clinical problem
- Author
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David Joergensen, Kiarash Tazmini, and Dag Jacobsen
- Subjects
Acute dysnatremia ,Hyponatremia ,Hypernatremia ,Water intoxication ,Salt intoxication ,Psychogenic polydipsia ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Dysnatremias are common electrolyte disturbances with significant morbidity and mortality. In chronic dysnatremias a slow correction rate ( 10 mmol/L/24 h). The median time of correction was 1 day in patients with hypo- and 2.5 days in patients with hypernatremia. The mortality was 7% in patients with hypo- and 29% in patients with hypernatremia. Interpretation Severe acute dysnatremias have significant mortality and require immediate treatment. A rapid correction rate may be lifesaving and is not associated with neurological complications. Chronic dysnatremias, on the other hand, are often compensated and thus less severe. In these cases a rapid correction rate may lead to severe cerebral complications.
- Published
- 2019
- Full Text
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49. Acute hyponatriemia in a patient with schizophrenia: Case report water intoxication induced acute hyponatriemia
- Author
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Naumovski Filip, Kuzmanovska Biljana, Kartalov Andrijan, Trposka Angela, Stojkovska Ana, and Toleska Marija
- Subjects
hyponatremia ,water intoxication ,hypertonic saline ,Anesthesiology ,RD78.3-87.3 - Abstract
Introduction: Hyponatremia is defined as a serum sodium level higher than 135 mmol/L, while serum sodium level lower 125 mmol/L is considered as severe hyponatremia and can lead to coma, death, rhabdomyolysis, and neurologic damage. Case report: We present the case of a 34 year old male with history of schizophrenia with multiple seizures followed by loss of consciousness after intake of 6 liters of water. Diagnostic CT scan revealed cerebral edema. Laboratory tests revealed severe hyponatremia (109 mmol/l), hypokalemia and hypocalcemia. The patient was treated with 10% hypertonic NaCl 120 ml per day, 7.4% KCl and calcium gluconate. He was sedated and mechanically ventilated. Antiedematous therapy with mannitol 20% was started. The biochemical results improved slowly with gradual correction of the sodium level: 112 mmol/l, 119 mmol/l and 127 mmol/l respectively. CT scan showed cerebral edema regression was showed on repeated brain scan. On the 6th day sodium level was 131 mmol/l, and the patient was awake, oriented and extubated. Discussion: Psychogenic polydipsia occurs in 20% of the psychiatric patients which could lead to severe hyponatremia. Second generation antipsychotics intake could also lead to severe hyponatremia. According guidelines hyponatremia treatment consists of hypertonic NaCl 3% 150 ml infusion and frequent sodium levels measurements. The sodium level correction should be gradual and should not exceed more than 10 mmol/l for the first 24 hours neither more than 8 mmol/L for every next 24 hours. Conclusion: In our patient, serum sodium level correction was successfully and safely performed with hypertonic saline (NaCl 10%) in absence of hypertonic NaCl 3%. Strict control of serum sodium levels is a must in order to avoid osmotic demielinisation and rhabdomyolysis.
- Published
- 2019
50. Water Intoxication
- Author
-
Lingampalli, Nithya
- Subjects
Water Intoxication - Published
- 2013
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