251. In-situ insertion of multi-walled carbon nanotubes in the Fe 3 O 4 /N/C composite derived from iron-based metal-organic frameworks as a catalyst for effective sensing acetaminophen and metronidazole.
- Author
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Yuan S, Bo X, and Guo L
- Subjects
- Acetaminophen blood, Acetaminophen urine, Catalysis, Electrochemical Techniques methods, Humans, Limit of Detection, Metronidazole blood, Metronidazole urine, Oxidation-Reduction, Acetaminophen analysis, Magnetite Nanoparticles chemistry, Metal-Organic Frameworks chemistry, Metronidazole analysis, Nanocomposites chemistry, Nanotubes, Carbon chemistry
- Abstract
In this paper, a novel Fe
3 O4 /N/C@MWCNTs composite derived from iron-based metal-organic frameworks (H2 N-Fe-MIL-88B) with multi-walled carbon nanotubes (MWCNTs) was prepared successfully through a simple calcination process. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy and electrochemical measurements were employed to comprehensive characterize the composites. Compare with the physical mixture, in-situ insertion of MWCNTs in the Fe3 O4 /N/C formed Fe3 O4 /N/C@MWCNTs composite has the higher conductivity, larger BET surface area and more satisfying electrocatalytic properties. Meanwhile, this composite with the reasonable combinations exhibits remarkable electrocatalytic activities for acetaminophen (AP) and metronidazole (MNZ) due to the synergistic interaction between the components. Thus, the Fe3 O4 /N/C@MWCNTs-2-600-based electrochemical sensor was established to effectively detect these two medicine molecules, respectively. In the optimized test conditions, the proposed sensor exhibits a wide linear response (0.5-5.0 μM and 5.0-1355.0 μM) for AP and the limit of detection (LOD) was achieved to be 0.14 μM (S/N = 3). Meanwhile, this sensor also shows two linear relationships with the concentration of MNZ in the range of 1.0 μM to 10.0 μM and 10.0 μM to 725.0 μM with the LOD of 0.19 μM (S/N = 3). Moreover, the satisfactory results were also acquired when the proposed sensor was used for the determination of AP and MNZ in the human serum and urine, demonstrating great promising of this electrochemical sensor for clinical applications., (Copyright © 2018 Elsevier B.V. All rights reserved.)- Published
- 2019
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