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51. The geometric albedo of the hot Jupiter HD 189733b measured with CHEOPS

Author

Krenn, A. F., Lendl, M., Patel, J. A., Carone, L., Deleuil, M., Sulis, S., Cameron, A. Collier, Deline, A., Guterman, P., Queloz, D., Fossati, L., Brandeker, A., Heng, K., Akinsanmi, B., Adibekyan, V., Bonfanti, A., Demangeon, O. D. S., Kitzmann, D., Salmon, S., Sousa, S. G., Wilson, T. G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Blecha, L., Bonfils, X., Borsato, L., Broeg, C., Cabrera, J., Charnoz, S., van Damme, C. Corral, Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Delrez, L., Demory, B. -O., Ehrenreich, D., Erikson, A., Farinato, J., Fortier, A., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hoyer, S., Isaak, K. G., Kiss, L. L., Kopp, E., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Mordasini, C., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., Van Grootel, V., Venturini, J., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Measurements of the occultation of an exoplanet at visible wavelengths allow us to determine the reflective properties of a planetary atmosphere. The observed occultation depth can be translated into a geometric albedo. This in turn aids in characterising the structure and composition of an atmosphere by providing additional information on the wavelength-dependent reflective qualities of the aerosols in the atmosphere. Aims. Our aim is to provide a precise measurement of the geometric albedo of the gas giant HD 189733b by measuring the occultation depth in the broad optical bandpass of CHEOPS (350 - 1100 nm). Methods. We analysed 13 observations of the occultation of HD 189733b performed by CHEOPS utilising the Python package PyCHEOPS. The resulting occultation depth is then used to infer the geometric albedo accounting for the contribution of thermal emission from the planet. We also aid the analysis by refining the transit parameters combining observations made by the TESS and CHEOPS space telescopes. Results. We report the detection of an $24.7 \pm 4.5$ ppm occultation in the CHEOPS observations. This occultation depth corresponds to a geometric albedo of $0.076 \pm 0.016$. Our measurement is consistent with models assuming the atmosphere of the planet to be cloud-free at the scattering level and absorption in the CHEOPS band to be dominated by the resonant Na doublet. Taking into account previous optical-light occultation observations obtained with the Hubble Space Telescope, both measurements combined are consistent with a super-stellar Na elemental abundance in the dayside atmosphere of HD 189733b. We further constrain the planetary Bond albedo to between 0.013 and 0.42 at 3$\sigma$ confidence., Comment: 17 pages, 10 figures, accepted for publication in A&A

Published
2023
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52. Discovery of TOI-1260d and the characterisation of the multi-planet system

Author

Lam, Kristine W. F., Cabrera, J., Hooton, M. J., Alibert, Y., Bonfanti, A., Beck, M., Deline, A., Florén, H. -G., Simon, A. E., Fossati, L., Persson, C. M., Fridlund, M., Salmon, S., Hoyer, S., Osborn, H. P., Wilson, T . G., Georgieva, I. Y., Nowak, Gr., Luque, R., Egger, J. A., Alonso, V. Adibekyan R., Escudé, G. Anglada, Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, T., Bekkelien, A., Benz, W., Billot, N., Bonfils, X., Brandeker, A., Broeg, C., Charnoz, S., Cameron, A. Collier, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Ehrenreich, D., Erikson, A., Fortier, A., Futyan, D., Gandolfi, D., Gillon, M., Guedel, M., Guterman, P., Laskar, J., Latham, D. W., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Heng, K., Isaak, K. G., Kiss, L., Magrin, D., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ribas, I., Ragazzoni, R., Rando, N., Rauer, H., Santos, N. C., Scandariato, G., Seager, S., Ségransan, D., Serrano, L. M., Smith, A. M. S., Sousa, S. G., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Van Grootel, V., Walton, N. A., and Winn, J. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We report the discovery of a third planet transiting the star TOI-1260, previously known to host two transiting sub-Neptune planets with orbital periods of 3.127 and 7.493 days, respectively. The nature of the third transiting planet with a 16.6-day orbit is supported by ground-based follow-up observations, including time-series photometry, high-angular resolution images, spectroscopy, and archival imagery. Precise photometric monitoring with CHEOPS allows to improve the constraints on the parameters of the system, improving our knowledge on their composition. The improved radii of TOI-1260b, TOI-1260c are $2.36 \pm 0.06 \rm R_{\oplus}$, $2.82 \pm 0.08 \rm R_{\oplus}$, respectively while the newly discovered third planet has a radius of $3.09 \pm 0.09 \rm R_{\oplus}$. The radius uncertainties are in the range of 3\%, allowing a precise interpretation of the interior structure of the three planets. Our planet interior composition model suggests that all three planets in the TOI-1260 system contains some fraction of gas. The innermost planet TOI-1260b has most likely lost all of its primordial hydrogen-dominated envelope. Planets c and d were also likely to have experienced significant loss of atmospheric through escape, but to a lesser extent compared to planet b., Comment: 18 pages, 10 figures, accepted for publication in MNRAS

Published
2022
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53. Connecting photometric and spectroscopic granulation signals with CHEOPS and ESPRESSO

Author

Sulis, S., Lendl, M., Cegla, H., Diaz, L. F. Rodriguez, Bigot, L., Van Grootel, V., Bekkelien, A., Cameron, A. Collier, Maxted, P. F. L., Simon, A. E., Lovis, C., Scandariato, G., Bruno, G., Nardiello, D., Bonfanti, A., Fridlund, M., Persson, C. M., Salmon, S., Sousa, S. G., Wilson, T. G., Krenn, A., Hoyer, S., Santerne, A., Ehrenreich, D., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Borsato, L., Brandeker, A., Broeg, C., Cabrera, J., Charnoz, S., van Damme, C. Corral, Csizmadia, Sz., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Erikson, A., Fortier, A., Fossati, L., Gandolfi, D., Gillon, M., Güdel, M., Heng, K., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Magrin, D., Munari, M., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Rieder, M., Santos, N. C., Ségransan, D., Smith, A. M. S., Steinberger, M., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Walton, N. A., and Wolter, D.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

Stellar granulation generates fluctuations in photometric and spectroscopic data whose properties depend on the stellar type, composition, and evolutionary state. In this study, we aim to detect the signatures of stellar granulation, link spectroscopic and photometric signatures of convection for main-sequence stars, and test predictions from 3D hydrodynamic models. For the first time, we observed two bright stars (Teff = 5833 K and 6205 K) with high-precision observations taken simultaneously with CHEOPS and ESPRESSO. We analyzed the properties of the stellar granulation signal in each individual data set. We compared them to Kepler observations and 3D hydrodynamic models. While isolating the granulation-induced changes by attenuating the p-mode oscillation signals, we studied the relationship between photometric and spectroscopic observables. The signature of stellar granulation is detected and precisely characterized for the hotter F star in the CHEOPS and ESPRESSO observations. For the cooler G star, we obtain a clear detection in the CHEOPS dataset only. The TESS observations are blind to this stellar signal. Based on CHEOPS observations, we show that the inferred properties of stellar granulation are in agreement with both Kepler observations and hydrodynamic models. Comparing their periodograms, we observe a strong link between spectroscopic and photometric observables. Correlations of this stellar signal in the time domain (flux vs RV) and with specific spectroscopic observables (shape of the cross-correlation functions) are however difficult to isolate due to signal-to-noise dependent variations. In the context of the upcoming PLATO mission and the extreme precision RV surveys, a thorough understanding of the properties of the stellar granulation signal is needed. The CHEOPS and ESPRESSO observations pave the way for detailed analyses of this stellar process., Comment: Accepted to A&A, 30 pages, 21 figures, 10 tables (one online)

Published
2022
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54. Examining the orbital decay targets KELT-9 b, KELT-16 b and WASP-4 b, and the transit-timing variations of HD 97658 b

Author

Harre, J. -V., Smith, A. M. S., Barros, S. C. C., Boué, G., Csizmadia, Sz., Ehrenreich, D., Florén, H. -G., Fortier, A., Maxted, P. F. L., Hooton, M. J., Akinsanmi, B., Serrano, L. M., Rosário, N. M., Demory, B. -O., Jones, K., Laskar, J., Adibekyan, V., Alibert, Y., Alonso, R., Anderson, D. R., Anglada, G., Asquier, J., Bárczy, T., Navascues, D. Barrado y, Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Biondi, F., Bonfanti, A., Bonfils, X., Brandeker, A., Broeg, C., Cabrera, J., Cessa, V., Charnoz, S., Cameron, A. Collier, Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O. D. S., Erikson, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hellier, C., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Luntzer, A., Magrin, D., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Persson, C. M., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Ricker, G. R., Salmon, S., Santos, N. C., Scandariato, G., Seager, S., Ségransan, D., Simon, A. E., Sousa, S. G., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., Van Grootel, V., Walton, N. A., Wilson, T. G., Winn, J. N., and Wohler, B.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Tidal orbital decay is suspected to occur especially for hot Jupiters, with the only observationally confirmed case of this being WASP-12 b. By examining this effect, information on the properties of the host star can be obtained using the so-called stellar modified tidal quality factor $Q_*'$, which describes the efficiency with which kinetic energy of the planet is dissipated within the star. This can help to get information about the interior of the star. In this study, we aim to improve constraints on the tidal decay of the KELT-9, KELT-16 and WASP-4 systems, to find evidence for or against the presence of this particular effect. With this, we want to constrain each star's respective $Q_*'$ value. In addition to that, we also aim to test the existence of the transit timing variations (TTVs) in the HD 97658 system, which previously favoured a quadratic trend with increasing orbital period. Making use of newly acquired photometric observations from CHEOPS and TESS, combined with archival transit and occultation data, we use Markov chain Monte Carlo (MCMC) algorithms to fit three models, a constant period model, an orbital decay model, and an apsidal precession model, to the data. We find that the KELT-9 system is best described by an apsidal precession model for now, with an orbital decay trend at over 2 $\sigma$ being a possible solution as well. A Keplerian orbit model with a constant orbital period fits the transit timings of KELT-16 b the best due to the scatter and scale of their error bars. The WASP-4 system is represented the best by an orbital decay model at a 5 $\sigma$ significance, although apsidal precession cannot be ruled out with the present data. For HD 97658 b, using recently acquired transit observations, we find no conclusive evidence for a previously suspected strong quadratic trend in the data., Comment: 19 pages, 11 figures, 9 tables, accepted for publication in A&A

Published
2022
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55. Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Author

Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca V.C. Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J. Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustín Albillos, Jesus M. Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Joachim L. Schultze, Olaf Riess, Andre Franke, Konrad Rawlik, David Ellinghaus, Alexander Hoischen, Axel Schmidt, Kerstin U. Ludwig, Valeria Rimoldi, Elvezia M. Paraboschi, Alessandra Bandera, Flora Peyvandi, Giacomo Grasselli, Francesco Blasi, Francesco Malvestiti, Serena Pelusi, Cristiana Bianco, Lorenzo Miano, Angela Lombardi, Pietro Invernizzi, Alessio Gerussi, Giuseppe Citerio, Andrea Biondi, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Giuseppe Foti, Ilaria Beretta, Mariella D'Angiò, Laura Rachele Bettini, Xavier Farré, Susana Iraola-Guzmán, Manolis Kogevinas, Gemma Castaño-Vinyals, Koldo Garcia-Etxebarria, Beatriz Nafria, Mauro D'Amato, Adriana Palom, Colin Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian Knight, Lowell Ling, David Maslove, Danny McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter J.M. Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar-Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard Clark, Audrey Coutts, Judy Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Fineran, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, Rachel Law, Sarah Law, Rebecca Lidstone-Scott, Louise Macgillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Owen Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Christopher Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, Christopher Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jeronimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Kumar Rohit, Frater Alasdair, Malik Saleem, Carter David, Jenkins Samuel, Zoe Lamond, Wall Alanna, Jaime Fernandez-Roman, David O. Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia A.C. Waite, Victoria Waugh, Ingeborg D. Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O'Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andres Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sohphie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Ceri Battle, Elaine Brinkworth, Rachel Harford, Carl Murphy, Luke Newey, Tabitha Rees, Marie Williams, Sophie Arnold, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Lina Grauslyte, Musarat Hussain, Mandeep Phull, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Laura Ortiz-Ruiz de Gordoa, Emily Peasgood, Claire Phillips, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, James Scriven, Carlos Castro Delgado, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Sarah Farnell-Ward, Abiola Harrison, Rebecca Kanu, Susannah Leaver, Elena Maccacari, Soumendu Manna, Romina Pepermans Saluzzio, Joana Queiroz, Tinashe Samakomva, Christine Sicat, Joana Texeira, Edna Fernandes Da Gloria, Ana Lisboa, John Rawlins, Jisha Mathew, Ashley Kinch, William James Hurt, Nirav Shah, Victoria Clark, Maria Thanasi, Nikki Yun, Kamal Patel, Sara Bennett, Emma Goodwin, Matthew Jackson, Alissa Kent, Clare Tibke, Wiesia Woodyatt, Ahmed Zaki, Azmerelda Abraheem, Peter Bamford, Kathryn Cawley, Charlie Dunmore, Maria Faulkner, Rumanah Girach, Helen Jeffrey, Rhianna Jones, Emily London, Imrun Nagra, Farah Nasir, Hannah Sainsbury, Clare Smedley, Tahera Patel, Matthew Smith, Srikanth Chukkambotla, Aayesha Kazi, Janice Hartley, Joseph Dykes, Muhammad Hijazi, Sarah Keith, Meherunnisa Khan, Janet Ryan-Smith, Philippa Springle, Jacqueline Thomas, Nick Truman, Samuel Saad, Dabheoc Coleman, Christopher Fine, Roseanna Matt, Bethan Gay, Jack Dalziel, Syamlan Ali, Drew Goodchild, Rhiannan Harling, Ravi Bhatterjee, Wendy Goddard, Chloe Davison, Stephen Duberly, Jeanette Hargreaves, Rachel Bolton, Miriam Davey, David Golden, Rebecca Seaman, Shiney Cherian, Sean Cutler, Anne Emma Heron, Anna Roynon-Reed, Tamas Szakmany, Gemma Williams, Owen Richards, Yusuf Cheema, Hollie Brooke, Sarah Buckley, Jose Cebrian Suarez, Ruth Charlesworth, Karen Hansson, John Norris, Alice Poole, Alastair Rose, Rajdeep Sandhu, Brendan Sloan, Elizabeth Smithson, Muthu Thirumaran, Veronica Wagstaff, Alexandra Metcalfe, Mark Brunton, Jess Caterson, Holly Coles, Matthew Frise, Sabi Gurung Rai, Nicola Jacques, Liza Keating, Emma Tilney, Shauna Bartley, Parminder Bhuie, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Bryan Yates, Jessica Reynolds, Helen Campbell, Maria Thompsom, Steve Dodds, Stacey Duffy, Sandra Greer, Karen Shuker, Ascanio Tridente, Reena Khade, Ashok Sundar, George Tsinaslanidis, Isobel Birkinshaw, Joseph Carter, Kate Howard, Joanne Ingham, Rosie Joy, Harriet Pearson, Samantha Roche, Zoe Scott, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, Maria Croft, Ian White, Victoria Frost, Maia Aquino, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Christine Almaden-Boyle, Pauline Austin, Louise Cabrelli, Stephen Cole, Matt Casey, Susan Chapman, Clare Whyte, Yolanda Baird, Aaron Butler, Indra Chadbourn, Linda Folkes, Heather Fox, Amy Gardner, Raquel Gomez, Gillian Hobden, Luke Hodgson, Kirsten King, Michael Margarson, Tim Martindale, Emma Meadows, Dana Raynard, Yvette Thirlwall, David Helm, Jordi Margalef, Kristine Criste, Rebecca Cusack, Kim Golder, Hannah Golding, Oliver Jones, Samantha Leggett, Michelle Male, Martyna Marani, Kirsty Prager, Toran Williams, Belinda Roberts, Karen Salmon, Peter Anderson, Katie Archer, Karen Austin, Caroline Davis, Alison Durie, Olivia Kelsall, Jessica Thrush, Charlie Vigurs, Laura Wild, Hannah-Louise Wood, Helen Tranter, Alison Harrison, Nicholas Cowley, Michael McAlindon, Andrew Burtenshaw, Stephen Digby, Emma Low, Aled Morgan, Naiara Cother, Tobias Rankin, Sarah Clayton, Alex McCurdy, Cecilia Ahmed, Balvinder Baines, Sarah Clamp, Julie Colley, Risna Haq, Anne Hayes, Jonathan Hulme, Samia Hussain, Sibet Joseph, Rita Kumar, Zahira Maqsood, Manjit Purewal, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Jason Cupitt, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Bethan Deacon, Ceri Lynch, Carla Pothecary, Lisa Roche, Gwenllian Sera Howe, Jayaprakash Singh, Keri Turner, Hannah Ellis, Natalie Stroud, Jodie Hunt, Joy Dearden, Emma Dobson, Andy Drummond, Michelle Mulcahy, Sheila Munt, Grainne O'Connor, Jennifer Philbin, Chloe Rishton, Redmond Tully, Sarah Winnard, Susanne Cathcart, Katharine Duffy, Alex Puxty, Kathryn Puxty, Lynne Turner, Jane Ireland, Gary Semple, Kate Long, Simon Whiteley, Elizabeth Wilby, Bethan Ogg, Amanda Cowton, Andrea Kay, Melanie Kent, Kathryn Potts, Ami Wilkinson, Suzanne Campbell, Ellen Brown, Julie Melville, Jay Naisbitt, Rosane Joseph, Maria Lazo, Olivia Walton, Alan Neal, Peter Alexander, Schvearn Allen, Joanne Bradley-Potts, Craig Brantwood, Jasmine Egan, Timothy Felton, Grace Padden, Luke Ward, Stuart Moss, Susannah Glasgow, Lynn Abel, Michael Brett, Brian Digby, Lisa Gemmell, James Hornsby, Patrick MacGoey, Pauline O'Neil, Richard Price, Natalie Rodden, Kevin Rooney, Radha Sundaram, Nicola Thomson, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Charlotte Downes, Kathleen Holding, Katie Riches, Mary Hilton, Mel Hayman, Deepak Subramanian, Priya Daniel, Oluronke Adanini, Nikhil Bhatia, Maines Msiska, Rebecca Collins, Ian Clement, Bijal Patel, A. Gulati, Carole Hays, K. Webster, Anne Hudson, Andrea Webster, Elaine Stephenson, Louise McCormack, Victoria Slater, Rachel Nixon, Helen Hanson, Maggie Fearby, Sinead Kelly, Victoria Bridgett, Philip Robinson, Julie Camsooksai, Charlotte Humphrey, Sarah Jenkins, Henrik Reschreiter, Beverley Wadams, Yasmin Death, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Gillian Bell, Katy English, Amro Katary, Louise Wilcox, Michelle Bruce, Karen Connolly, Tracy Duncan, Helen T-Michael, Gabriella Lindergard, Samuel Hey, Claire Fox, Jordan Alfonso, Laura Jayne Durrans, Jacinta Guerin, Bethan Blackledge, Jade Harris, Martin Hruska, Ayaa Eltayeb, Thomas Lamb, Tracey Hodgkiss, Lisa Cooper, Joanne Rothwell, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Liana Lankester, Nikitas Nikitas, Colin Wells, Bethan Stowe, Kayleigh Spencer, Craig Brandwood, Lara Smith, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Elena Apetri, Cathrine Basikolo, Laura Catlow, Bethan Charles, Paul Dark, Reece Doonan, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Tracey Cosier, Gemma Millen, Neil Richardson, Natasha Schumacher, Heather Weston, James Rand, Nicola Baxter, Steven Henderson, Sophie Kennedy-Hay, Christopher McParland, Laura Rooney, Malcolm Sim, Gordan McCreath, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Jeremy Bewley, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Rebekah Johnson, Katie Sweet, Denise Webster, Georgia Efford, Karen Convery, Deirdre Fottrell-Gould, Lisa Hudig, Jocelyn Keshet-Price, Georgina Randell, Katie Stammers, Maria Bokhari, Vanessa Linnett, Rachael Lucas, Wendy McCormick, Jenny Ritzema, Amanda Sanderson, Helen Wild, Anthony Rostron, Alistair Roy, Lindsey Woods, Sarah Cornell, Fiona Wakinshaw, Kimberley Rogerson, Jordan Jarmain, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Georgia Bercades, David Brealey, Ingrid Hass, Niall MacCallum, Gladys Martir, Eamon Raith, Anna Reyes, Deborah Smyth, Letizia Zitter, Sarah Benyon, Suzie Marriott, Linda Park, Samantha Keenan, Elizabeth Gordon, Helen Quinn, Kizzy Baines, Lenka Cagova, Adama Fofano, Lucie Garner, Helen Holcombe, Sue Mepham, Alice Michael Mitchell, Lucy Mwaura, Krithivasan Praman, Alain Vuylsteke, Julie Zamikula, Bally Purewal, Vanessa Rivers, Stephanie Bell, Hayley Blakemore, Borislava Borislavova, Beverley Faulkner, Emma Gendall, Elizabeth Goff, Kati Hayes, Matt Thomas, Ruth Worner, Kerry Smith, Deanna Stephens, Louise Mew, Esther Mwaura, Richard Stewart, Felicity Williams, Lynn Wren, Sara-Beth Sutherland, Emily Bevan, Jane Martin, Dawn Trodd, Geoff Watson, Caroline Wrey Brown, Amy Collins, Waqas Khaliq, Estefania Treus Gude, Olugbenga Akinkugbe, Alasdair Bamford, Emily Beech, Holly Belfield, Michael Bell, Charlene Davies, Gareth A.L. Jones, Tara McHugh, Hamza Meghari, Lauran O'Neill, Mark J. Peters, Samiran Ray, Ana Luisa Tomas, Iona Burn, Geraldine Hambrook, Katarina Manso, Ruth Penn, Pradeep Shanmugasundaram, Julie Tebbutt, Danielle Thornton, Jade Cole, Rhys Davies, Donna Duffin, Helen Hill, Ben Player, Emma Thomas, Angharad Williams, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Reni Jacob, Cathy Jones, Craig Denmade, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Patricia Doble, Joanne Hutter, Corinne Pawley, Charmaine Shovelton, Marius Vaida, Deborah Butcher, Susie O'Sullivan, Nicola Butterworth-Cowin, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Gary H. Mills, Ajay Raithatha, Matthew Wiles, Jayne Willson, Helen Newell, Alison Lye, Lorenza Nwafor, Claire Jarman, Sarah Rowland-Jones, David Foote, Joby Cole, Roger Thompson, James Watson, Lisa Hesseldon, Irene Macharia, Luke Chetam, Jacqui Smith, Amber Ford, Samantha Anderson, Kathryn Birchall, Kay Housley, Sara Walker, Leanne Milner, Helena Hanratty, Helen Trower, Patrick Phillips, Simon Oxspring, Ben Donne, Catherine Jardine, Dewi Williams, Alasdair Hay, Rebecca Flanagan, Gareth Hughes, Scott Latham, Emma McKenna, Jennifer Anderson, Robert Hull, Kat Rhead, Carina Cruz, Natalie Pattison, Rob Charnock, Denise McFarland, Denise Cosgrove, Ashar Ahmed, Anna Morris, Srinivas Jakkula, Asifa Ali, Megan Brady, Sam Dale, Annalisa Dance, Lisa Gledhill, Jill Greig, Kathryn Hanson, Kelly Holdroyd, Marie Home, Diane Kelly, Ross Kitson, Lear Matapure, Deborah Melia, Samantha Mellor, Tonicha Nortcliffe, Jez Pinnell, Matthew Robinson, Lisa Shaw, Ryan Shaw, Lesley Thomis, Alison Wilson, Tracy Wood, Lee-Ann Bayo, Ekta Merwaha, Tahira Ishaq, Sarah Hanley, Meg Hibbert, Dariusz Tetla, Chrsitopher Woodford, Latha Durga, Gareth Kennard-Holden, Debbie Branney, Jordan Frankham, Sally Pitts, Nigel White, Shondipon Laha, Mark Verlander, Alexandra Williams, Abdelhakim Altabaibeh, Ana Alvaro, Kayleigh Gilbert, Louise Ma, Loreta Mostoles, Chetan Parmar, Kathryn Simpson, Champa Jetha, Lauren Booker, Anezka Pratley, Colene Adams, Anita Agasou, Tracie Arden, Amy Bowes, Pauline Boyle, Mandy Beekes, Heather Button, Nigel Capps, Mandy Carnahan, Anne Carter, Danielle Childs, Denise Donaldson, Kelly Hard, Fran Hurford, Yasmin Hussain, Ayesha Javaid, James Jones, Sanal Jose, Michael Leigh, Terry Martin, Helen Millward, Nichola Motherwell, Rachel Rikunenko, Jo Stickley, Julie Summers, Louise Ting, Helen Tivenan, Louise Tonks, Rebecca Wilcox, Maureen Holland, Natalie Keenan, Marc Lyons, Helen Wassall, Chris Marsh, Mervin Mahenthran, Emma Carter, Thomas Kong, Helen Blackman, Ben Creagh-Brown, Sinead Donlon, Natalia Michalak-Glinska, Sheila Mtuwa, Veronika Pristopan, Armorel Salberg, Eleanor Smith, Sarah Stone, Charles Piercy, Jerik Verula, Dorota Burda, Rugia Montaser, Lesley Harden, Irving Mayangao, Cheryl Marriott, Paul Bradley, Celia Harris, Susan Anderson, Eleanor Andrews, Janine Birch, Emma Collins, Kate Hammerton, Ryan O'Leary, Michele Clark, Sarah Purvis, Russell Barber, Claire Hewitt, Annette Hilldrith, Karen Jackson-Lawrence, Sarah Shepardson, Maryanne Wills, Susan Butler, Silvia Tavares, Amy Cunningham, Julia Hindale, Sarwat Arif, Sarah Bean, Karen Burt, Michael Spivey, Carrie Demetriou, Charlotte Eckbad, Sarah Hierons, Lucy Howie, Sarah Mitchard, Lidia Ramos, Alfredo Serrano-Ruiz, Katie White, Fiona Kelly, Daniele Cristiano, Natalie Dormand, Zohreh Farzad, Mahitha Gummadi, Kamal Liyanage, Brijesh Patel, Sara Salmi, Geraldine Sloane, Vicky Thwaites, Mathew Varghese, Anelise C. Zborowski, John Allan, Tim Geary, Gordon Houston, Alistair Meikle, Peter O'Brien, Miranda Forsey, Agilan Kaliappan, Anne Nicholson, Joanne Riches, Mark Vertue, Elizabeth Allan, Kate Darlington, Ffyon Davies, Jack Easton, Sumit Kumar, Richard Lean, Daniel Menzies, Richard Pugh, Xinyi Qiu, Llinos Davies, Hannah Williams, Jeremy Scanlon, Gwyneth Davies, Callum Mackay, Joannne Lewis, Stephanie Rees, Metod Oblak, Monica Popescu, Mini Thankachen, Andrew Higham, Kerry Simpson, Jayne Craig, Rosie Baruah, Sheila Morris, Susie Ferguson, Amy Shepherd, Luke Stephen Prockter Moore, Marcela Paola Vizcaychipi, Laura Gomes de Almeida Martins, Jaime Carungcong, Inthakab Ali Mohamed Ali, Karen Beaumont, Mark Blunt, Zoe Coton, Hollie Curgenven, Mohamed Elsaadany, Kay Fernandes, Sameena Mohamed Ally, Harini Rangarajan, Varun Sarathy, Sivarupan Selvanayagam, Dave Vedage, Matthew White, Mandy Gill, Paul Paul, Valli Ratnam, Sarah Shelton, Inez Wynter, Siobhain Carmody, Valerie Joan Page, Claire Marie Beith, Karen Black, Suzanne Clements, Alan Morrison, Dominic Strachan, Margaret Taylor, Michelle Clarkson, Stuart D'Sylva, Kathryn Norman, Fiona Auld, Joanne Donnachie, Ian Edmond, Lynn Prentice, Nikole Runciman, Dario Salutous, Lesley Symon, Anne Todd, Patricia Turner, Abigail Short, Laura Sweeney, Euan Murdoch, Dhaneesha Senaratne, Michaela Hill, Thogulava Kannan, Wild Laura, Rikki Crawley, Abigail Crew, Mishell Cunningham, Allison Daniels, Laura Harrison, Susan Hope, Ken Inweregbu, Sian Jones, Nicola Lancaster, Jamie Matthews, Alice Nicholson, Gemma Wray, Helen Langton, Rachel Prout, Malcolm Watters, Catherine Novis, Anthony Barron, Ciara Collins, Sundeep Kaul, Heather Passmore, Claire Prendergast, Anna Reed, Paula Rogers, Rajvinder Shokkar, Meriel Woodruff, Hayley Middleton, Oliver Polgar, Claire Nolan, Kanta Mahay, Dawn Collier, Anil Hormis, Victoria Maynard, Cheryl Graham, Rachel Walker, Ellen Knights, Alicia Price, Alice Thomas, Chris Thorpe, Teresa Behan, Caroline Burnett, Jonathan Hatton, Elaine Heeney, Atideb Mitra, Maria Newton, Rachel Pollard, Rachael Stead, Vishal Amin, Elena Anastasescu, Vikram Anumakonda, Komala Karthik, Rizwana Kausar, Karen Reid, Jacqueline Smith, Janet Imeson-Wood, Denise Skinner, Jane Gaylard, Dee Mullan, Julie Newman, Alison Brown, Vikki Crickmore, Gabor Debreceni, Joy Wilkins, Liz Nicol, Rosie Reece-Anthony, Mark Birt, Alison Ghosh, Emma Williams, Louise Allen, Eva Beranova, Nikki Crisp, Joanne Deery, Tracy Hazelton, Alicia Knight, Carly Price, Sorrell Tilbey, Salah Turki, Sharon Turney, Joshua Cooper, Cheryl Finch, Sarah Liderth, Alison Quinn, Natalia Waddington, Tina Coventry, Susan Fowler, Michael MacMahon, Amanda McGregor, Anne Cowley, Judith Highgate, Jane Gregory, Susan O'Connell, Tim Smith, Luigi Barberis, Shameer Gopal, Nichola Harris, Victoria Lake, Stella Metherell, Elizabeth Radford, Amelia Daniel, Joanne Finn, Rajnish Saha, Nikki White, Phil Donnison, Fiona Trim, Beena Eapen, Jenny Birch, Laura Bough, Josie Goodsell, Rebecca Tutton, Patricia Williams, Sarah Williams, Barbara Winter-Goodwin, Ailstair Nichol, Kathy Brickell, Michelle Smyth, Lorna Murphy, Samantha Coetzee, Alistair Gales, Igor Otahal, Meena Raj, Craig Sell, Paula Hilltout, Jayne Evitts, Amanda Tyler, Joanne Waldron, Kate Beesley, Sarah Board, Agnieszka Kubisz-Pudelko, Alison Lewis, Jess Perry, Lucy Pippard, Di Wood, Clare Buckley, Peter Barry, Neil Flint, Patel Rekha, Dawn Hales, Lara Bunni, Claire Jennings, Monica Latif, Rebecca Marshall, Gayathri Subramanian, Peter J. McGuigan, Christopher Wasson, Stephanie Finn, Jackie Green, Erin Collins, Bernadette King, Andy Campbell, Sara Smuts, Joseph Duffield, Oliver Smith, Lewis Mallon, Watkins Claire, Liam Botfield, Joanna Butler, Catherine Dexter, Jo Fletcher, Atul Garg, Aditya Kuravi, Poonam Ranga, Emma Virgilio, Zakaula Belagodu, Bridget Fuller, Anca Gherman, Olumide Olufuwa, Remi Paramsothy, Carmel Stuart, Naomi Oakley, Charlotte Kamundi, David Tyl, Katy Collins, Pedro Silva, June Taylor, Laura King, Charlotte Coates, Maria Crowley, Phillipa Wakefield, Jane Beadle, Laura Johnson, Janet Sargeant, Madeleine Anderson, Ailbhe Brady, Rebekah Chan, Jeff Little, Shane McIvor, Helena Prady, Helen Whittle, Bijoy Mathew, Ben Attwood, Penny Parsons, Geraldine Ward, Pamela Bremmer, West Joe, Baird Tracy, Ruddy Jim, Ellie Davies, Sonia Sathe, Catherine Dennis, Alastair McGregor, Victoria Parris, Sinduya Srikaran, Anisha Sukha, Noreen Clarke, Jonathan Whiteside, Mairi Mascarenhas, Avril Donaldson, Joanna Matheson, Fiona Barrett, Marianne O'Hara, Laura Okeefe, Clare Bradley, Christine Eastgate-Jackson, Helder Filipe, Daniel Martin, Amitaa Maharajh, Sara Mingo Garcia, Glykeria Pakou, Mark De Neef, Kathy Dent, Elizabeth Horsley, Muhmmad Nauman Akhtar, Sandra Pearson, Dorota Potoczna, Sue Spencer, Melanie Clapham, Rosemary Harper, Una Poultney, Polly Rice, Rachel Mutch, Lisa Armstrong, Hayley Bates, Emma Dooks, Fiona Farquhar, Brigid Hairsine, Chantal McParland, Sophie Packham, Rehana Bi, Barney Scholefield, Lydia Ashton, Linsha George, Sophie Twiss, David Wright, Manish Chablani, Amy Kirkby, Kimberley Netherton, Kim Davies, Linda O'Brien, Zohra Omar, Emma Perkins, Tracy Lewis, Isobel Sutherland, Karen Burns, Dr Ben Chandler, Kerry Elliott, Janine Mallinson, Alison Turnbull, Prisca Gondo, Bernard Hadebe, Abdul Kayani, Bridgett Masunda, Taya Anderson, Dan Hawcutt, Laura O'Malley, Laura Rad, Naomi Rogers, Paula Saunderson, Kathryn Sian Allison, Deborah Afolabi, Jennifer Whitbread, Dawn Jones, Rachael Dore, Matthew Halkes, Pauline Mercer, Lorraine Thornton, Joy Dawson, Sweyn Garrioch, Melanie Tolson, Jonathan Aldridge, Ritoo Kapoor, David Loader, Karen Castle, Sally Humphreys, Ruth Tampsett, Katherine Mackintosh, Amanda Ayers, Wendy Harrison, Julie North, Suzanne Allibone, Roman Genetu, Vidya Kasipandian, Amit Patel, Ainhi Mac, Anthony Murphy, Parisa Mahjoob, Roonak Nazari, Lucy Worsley, Andrew Fagan, Thomas Bemand, Ethel Black, Arnold Dela Rosa, Ryan Howle, Shaman Jhanji, Ravishankar Rao Baikady, Kate Colette Tatham, Benjamin Thomas, Dina Bell, Rosalind Boyle, Katie Douglas, Lynn Glass, Emma Lee, Liz Lennon, Austin Rattray, Abigail Taylor, Rachel Anne Hughes, Helen Thomas, Alun Rees, Michaela Duskova, Janet Phipps, Suzanne Brooks, Michelle Edwards, Sheena Quaid, Ekaterina Watson, Adam Brayne, Emma Fisher, Jane Hunt, Peter Jackson, Duncan Kaye, Nicholas Love, Juliet Parkin, Victoria Tuckey, Lynne Van Koutrik, Sasha Carter, Benedict Andrew, Louise Findlay, Katie Adams, Jen Service, Alison Williams, Claire Cheyne, Anne Saunderson, Sam Moultrie, Miranda Odam, Kathryn Hall, Isheunesu Mapfunde, Charlotte Willis, Alex Lyon, Chunda Sri-Chandana, Joslan Scherewode, Lorraine Stephenson, Sarah Marsh, John Hardy, Henry Houlden, Eleanor Moncur, Ambreen Tariq, Arianna Tucci, Maria Hobrok, Ronda Loosley, Heather McGuinness, Helen Tench, Rebecca Wolf-Roberts, Val Irvine, Benjamin Shelley, Claire Gorman, Abhinav Gupta, Elizabeth Timlick, Rebecca Brady, Barry Milligan, Arianna Bellini, Jade Bryant, Anton Mayer, Amy Pickard, Nicholas Roe, Jason Sowter, Alex Howlett, Katy Fidler, Emma Tagliavini, and Kevin Donnelly

Subjects
SARS-CoV-2, host genetics, toll-like receptor 7, targeted sequencing, rare variants, variant collapsing analysis, Genetics, QH426-470
Abstract

Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (

Published
2024
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56. Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona)Research in context

Author

Valentina Mazzotta, Silvia Nozza, Simone Lanini, Davide Moschese, Alessandro Tavelli, Roberto Rossotti, Francesco Maria Fusco, Lorenzo Biasioli, Giulia Matusali, Angelo Roberto Raccagni, Davide Mileto, Chiara Maci, Giuseppe Lapadula, Antonio Di Biagio, Luca Pipitò, Enrica Tamburrini, Antonella d’Arminio Monforte, Antonella Castagna, Andrea Antinori, Spinello Antinori, Chiara Baiguera, Gianmaria Baldin, Matteo Bassetti, Paolo Bonfanti, Giorgia Brucci, Elena Bruzzesi, Caterina Candela, Antonio Cascio, Antonella d'Arminio Monforte, Andrea Delama, Gabriella D'Ettorre, Damiano Farinacci, Maria Rita Gismondo, Andrea Gori, Massimiliano Lanzafame, Miriam Lichtner, Giulia Mancarella, Alessandro Mancon, Giulia Marchetti, Emanuele Nicastri, Alessandro Pandolfo, Francesca Panzo, Stefania Piconi, Carmela Pinnetti, Alessandro Raimondi, Marco Ridolfi, Giuliano Rizzardini, Alessandra Rodanò, Margherita Sambo, Vincenzo Sangiovanni, Nadia Sangiovanni, Daniele Tesoro, and Serena Vita

Subjects
mpox, Severity, MPOXV, Evolution, Recovery, Ct-value, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: Severe and prolonged mpox courses have been described during the 2022–2023 outbreak. Identifying predictors of severe evolution is crucial for improving management and therapeutic strategies. We explored the predictors of mpox severity and tested the association between mpox severity and viral load in biological fluids. We also analysed the predictors of disease duration and kinetics of inflammatory markers and described the viral presence and duration of shedding in biological fluids. Methods: This multicentre historical cohort study included adults diagnosed with laboratory-confirmed mpox diagnosis between May 2022 and September 2023 at 15 Italian centres. Patients were followed up from the day of diagnosis until clinical recovery. Biological fluids (blood, urine, saliva, and oropharyngeal and rectal swabs) were collected from each subgroup during the course of the disease and after healing. The primary outcomes were disease severity (presence of mucosal involvement, extended rash, or need for hospitalisation) and its association with the cycle threshold value (Ct-value, surrogate of viral load) in biological fluids, using standard linear and linear mixed-effect logistic regression models. Among the secondary outcomes, predictors of disease duration were assessed using a linear regression model. Findings: A total of 541 patients were enrolled, including four (0.74%) women, with a median age of 38 years (IQR 33–44). Among the 235 people living with HIV (PLWH) (43.44%), 22 (4.07%) had a CD4 count lower than 350 cells/μL. Severe mpox was reported in 215 patients (39.74%). No patient died. Multivariable analysis showed that, severe mpox was more likely among Caucasians (OR 1.82; 95% CI 1.14–2.90, p = 0.012) and patients who had an onset of fever (1.95; 1.27–2.99, p = 0.002), lymphadenopathy (2.30; 1.52–3.48, p

Published
2024
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57. Monoclonal antibodies against SARS-CoV-2 to prevent COVID-19 worsening in a large multicenter cohort

Author

Alessandro Soria, Francesca Graziano, Giulia Ghilardi, Giuseppe Lapadula, Daniela Dalla Gasperina, Simone Vasilij Benatti, Eugenia Quiros-Roldan, Maurizio Milesi, Francesca Bai, Marco Merli, Davide Minisci, Marco Franzetti, Erika Asperges, Filippo Chiabrando, Daria Pocaterra, Alessandro Pandolfo, Fabio Zanini, Domenico Lombardi, Anna Cappelletti, Alban Rugova, Maria Lucia Borghesi, Nicola Squillace, Luigi Pusterla, Stefania Piconi, Paola Morelli, Patrizia Rovere Querini, Raffaele Bruno, Stefano Rusconi, Salvatore Casari, Alessandra Bandera, Fabio Franzetti, Giovanna Travi, Antonella D'Arminio Monforte, Giulia Marchetti, Angelo Pan, Francesco Castelli, Marco Rizzi, Francesco Dentali, Maria Mallardo, Emanuela Rossi, Maria Grazia Valsecchi, Stefania Galimberti, and Paolo Bonfanti

Subjects
Monoclonal antibodies, COVID-19, SARS-CoV-2, Hospitalization, Immunodeficiency, Omicron variant, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Objective: Monoclonal antibodies (mAbs) against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reduced Coronavirus Disease 2019 (COVID-19) hospitalizations in people at risk of clinical worsening. Real-world descriptions are limited. Methods: CONDIVIDIAMO, a two-year multicenter observational study, consecutively enrolled SARS-CoV-2 outpatients with ≥1 risk factor for COVID-19 progression receiving mAbs. Demographic data, underlying medical condition, type of mAbs combination received, duration of symptoms before mAbs administration, COVID-19 vaccination history, were collected upon enrolment and centrally recorded. Data on outcomes (hospitalizations, reasons of hospitalization, deaths) were prospectively collected. The primary endpoint was the rate of hospitalization or death in a 28-day follow-up, whichever occurred first; subjects were censored at the day of last follow-up or up to 28 days. The Kaplan-Meier method was used to estimate the incidence rate curve in time. The Cox regression model was used to assess potential risk factors for unfavorable outcome. Results were shown as hazard ratio (HR) along with the corresponding 95 % Confidence Interval (95%CI). Results: Among 1534 subjects (median [interquartile range, IQR] age 66.5 [52.4–74.9] years, 693 [45.2 %] women), 632 (41.2 %) received bamlanivimab ± etesevimab, 209 (13.6 %) casirivimab/imdevimab, 586 (38.2 %) sotrovimab, 107 (7.0 %) tixagevimab/cilgavimab. After 28-day follow-up, 87/1534 (5.6 %, 95%CI: 4.4%–6.8 %) met the primary outcome (85 hospitalizations, 2 deaths). Hospitalizations for COVID-19 (52, 3.4 %) occurred earlier than for other reasons (33, 2.1 %), after a median (IQR) of 3.5 (1–7) versus 8 (3–15) days (p = 0.006) from mAbs administration.In a multivariable Cox regression model, factors independently associated with increased hospitalization risk were age (hazard ratio [HR] 1.02, 95%CI 1.00–1.03, p = 0.021), immunodeficiency (HR 1.78, 95%CI 1.11–2.85, p = 0.017), pre-Omicron calendar period (HR 1.66, 95%CI 1.02–2.69, p = 0.041). Conclusions: MAbs real-world data over a 2-year changing pandemic landscape showed the feasibility of the intervention, although the hospitalization rate was not negligible. Immunosuppressed subjects remain more at risk of clinical worsening.

Published
2024
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58. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Author

Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, and Zucchini Stefano

Subjects
adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closed-loop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using “smart pumps” or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose

Published
2024
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59. Characterization of the HD 108236 system with CHEOPS and TESS. Confirmation of a fifth transiting planet

Author

Hoyer, S., Bonfanti, A., Leleu, A., Acuña, L., Serrano, L. M., Deleuil, M., Bekkelien, A., Broeg, C., Floren, H. -G., Queloz, D., Wilson, T. G., Sousa, S. G., Hooton, M. J., Adibekyan, V., Alibert, Y., Alonso, R., Anglada, G., Asquier, J., Bárczy, T., Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Biondi, F., Bonfils, X., Brandeker, A., Cabrera, J., Charnoz, S., Cameron, A. Collier, Csizmadia, Sz., Davies, M. B., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Ehrenreich, D., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hara, N., Heng, K., Isaak, K. G., Jenkins, J. M., Kiss, L. L., Laskar, J., Latham, D. W., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Luntzer, A., Magrin, D., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Persson, C. M., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Ricker, G. R., Salmon, S., Santos, N. C., Scandariato, G., Seager, S., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Twicken, J. D., Udry, S., Van Grootel, V., Vanderspek, R. K., Walton, N. A., Westerdorff, K., and Winn, J. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The HD108236 system was first announced with the detection of four small planets based on TESS data. Shortly after, the transit of an additional planet with a period of 29.54d was serendipitously detected by CHEOPS. In this way, HD108236 (V=9.2) became one of the brightest stars known to host five small transiting planets (R$_p$<3R$_{\oplus}$). We characterize the planetary system by using all the data available from CHEOPS and TESS space missions. We use the flexible pointing capabilities of CHEOPS to follow up the transits of all the planets in the system, including the fifth transiting body. After updating the host star parameters by using the results from Gaia eDR3, we analyzed 16 and 43 transits observed by CHEOPS and TESS, respectively, to derive the planets physical and orbital parameters. We carried out a timing analysis of the transits of each of the planets of HD108236 to search for the presence of transit timing variations. We derived improved values for the radius and mass of the host star (R$_{\star}$=0.876$\pm$0.007 R$_{\odot}$ and M$_{\star}$=0.867$_{-0.046}^{+0.047}$ M$_{\odot}$). We confirm the presence of the fifth transiting planet f in a 29.54d orbit. Thus, the system consists of five planets of R$_b$=1.587$\pm$0.028, R$_c$=2.122$\pm$0.025, R$_d$=2.629$\pm$0.031, R$_e$=3.008$\pm$0.032, and R$_f$=1.89$\pm$0.04 [R$_{\oplus}$]. We refine the transit ephemeris for each planet and find no significant transit timing variations for planets c, d, and e. For planets b and f, instead, we measure significant deviations on their transit times (up to 22 and 28 min, respectively) with a non-negligible dispersion of 9.6 and 12.6 min in their time residuals. We confirm the presence of planet f and find no significant evidence for a potential transiting planet in a 10.9d orbital period, as previously suggested. Full abstract in the PDF file., Comment: 18 Figures and 25 pages. Accepted for publication in A&A

Published
2022
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60. A CHEOPS-enhanced view of the HD3167 system

Author

Bourrier, V., Deline, A., Krenn, A., Egger, J. A., Petit, A. C., Malavolta, L., Cretignier, M., Billot, N., Broeg, C., Florén, H. -G., Queloz, D., Alibert, Y., Bonfanti, A., Bonomo, A. S., Delisle, J. -B., Demangeon, O. D. S., Demory, B. -O., Dumusque, X., Ehrenreich, D., Haywood, R. D., Howell, S. B, Lendl, M., Mortier, A., Nigro, G., Salmon, S., Sousa, S. G., Wilson, T. G., Adibekyan, V., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Benz, W., Biondi, F., Bonfils, X., Brandeker, A., Cabrera, J., Charnoz, S., Csizmadia, Sz., Cameron, A. Collier, Damasso, M., Davies, M. B., Deleuil, M., Delrez, L., Di Fabrizio, L., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lorenzi, V., Lovis, C., Magrin, D., Massa, A., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Van Grootel, V., Verrecchia, F., Walton, N., Beck, T., Buder, M., Ratti, F., Ulmer, B., and Viotto, V.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Much remains to be understood about the nature of exoplanets smaller than Neptune, most of which have been discovered in compact multi-planet systems. With its inner ultra-short period planet b aligned with the star and two larger outer planets d-c on polar orbits, the multi-planet system HD 3167 features a peculiar architecture and offers the possibility to investigate both dynamical and atmospheric evolution processes. To this purpose we combined multiple datasets of transit photometry and radial velocimetry (RV) to revise the properties of the system and inform models of its planets. This effort was spearheaded by CHEOPS observations of HD 3167b, which appear inconsistent with a purely rocky composition despite its extreme irradiation. Overall the precision on the planetary orbital periods are improved by an order of magnitude, and the uncertainties on the densities of the transiting planets b and c are decreased by a factor of 3. Internal structure and atmospheric simulations draw a contrasting picture between HD 3167d, likely a rocky super-Earth that lost its atmosphere through photo-evaporation, and HD 3167c, a mini-Neptune that kept a substantial primordial gaseous envelope. We detect a fourth, more massive planet on a larger orbit, likely coplanar with HD 3167d-c. Dynamical simulations indeed show that the outer planetary system d-c-e was tilted, as a whole, early in the system history, when HD 3167b was still dominated by the star influence and maintained its aligned orbit. RV data and direct imaging rule out that the companion that could be responsible for the present-day architecture is still bound to the HD\,3167 system. Similar global studies of multi-planet systems will tell how many share the peculiar properties of the HD3167 system, which remains a target of choice for follow-up observations and simulations., Comment: 22 pages, 23 pages, accepted for publication in A&A (18 August 2022). Updated author list in new version

Published
2022
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61. The phase curve and the geometric albedo of WASP-43b measured with CHEOPS, TESS and HST WFC3/UVIS

Author

Scandariato, G., Singh, V., Kitzmann, D., Lendl, M., Brandeker, A., Bruno, G., Bekkelien, A., Benz, W., Gutermann, P., Maxted, P. F. L., Bonfanti, A., Charnoz, S., Fridlund, M., Heng, K., Hoyer, S., Pagano, I., Persson, C. M., Salmon, S., Van Grootel, V., Wilson, T. G., Asquier, J., Bergomi, M., Gambicorti, L., Hasiba, J., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Billot, N., Bonfils, X., Broeg, C., Cabrera, J., Cameron, A. Collier, Csizmadia, Sz., Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Demangeon, O., Demory, B. -O., Erikson, A., Fortier, A., Fossati, L., Gandolfi, D., Gillon, M., Güdel, M., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pallé, E., Parviainen, H., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Ségransan, D., Serrano, L. M., Simon, A. E., Smith, A. M. S., Sousa, S. G., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., and Walton, N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Observations of the phase curves and secondary eclipses of extrasolar planets provide a window on the composition and thermal structure of the planetary atmospheres. For example, the photometric observations of secondary eclipses lead to the measurement of the planetary geometric albedo $A_g$, which is an indicator of the presence of clouds in the atmosphere. In this work we aim to measure the $A_g$ in the optical domain of WASP-43b, a moderately irradiated giant planet with an equilibrium temperature of $\sim$1400~K. To this purpose, we analyze the secondary eclipse light curves collected by CHEOPS, together with TESS observations of the system and the publicly available photometry obtained with HST WFC3/UVIS. We also analyze the archival infrared observations of the eclipses and retrieve the thermal emission spectrum of the planet. By extrapolating the thermal spectrum to the optical bands, we correct the optical eclipses for thermal emission and derive the optical $A_g$. The fit of the optical data leads to a marginal detection of the phase curve signal, characterized by an amplitude of $160\pm60$~ppm and 80$^{+60}_{-50}$~ppm in the CHEOPS and TESS passband respectively, with an eastward phase shift of $\sim50^\circ$ (1.5$\sigma$ detection). The analysis of the infrared data suggests a non-inverted thermal profile and solar-like metallicity. The combination of optical and infrared analysis allows us to derive an upper limit for the optical albedo of $A_g<0.087$ with a confidence of 99.9\%. Our analysis of the atmosphere of WASP-43b places this planet in the sample of irradiated hot Jupiters, with monotonic temperature-pressure profile and no indication of condensation of reflective clouds on the planetary dayside.

Published
2022
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62. CHEOPS finds KELT-1b darker than expected in visible light: Discrepancy between the CHEOPS and TESS eclipse depths

Author

Parviainen, H., Wilson, T. G., Lendl, M., Kitzmann, D., Pallé, E., Serrano, L. M., Valdes, E. Meier, Benz, W., Deline, A., Ehrenreich, D., Guterman, P., Heng, K., Demangeon, O. D. S., Bonfanti, A., Salmon, S., Singh, V., Santos, N. C., Sousa, S. G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Billot, N., Bonfils, X., Brandeker, A., Broeg, C., Cabrera, J., Charnoz, S., Cameron, A. Collier, Van Damme, C. Corral, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demory, B. -O., Erikson, A., Farinato, J., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hoyer, S., Isaak, K. G., Kiss, L. L., Kopp, E., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Mecina, M., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Queloz, D., Ragazzoi, R., Rando, N., Rauer, H., Ribas, I., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., VanGrootel, V., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Recent TESS-based studies have suggested that the dayside of KELT-1b, a strongly-irradiated brown dwarf, is significantly brighter in visible light than what would be expected based on Spitzer observations in infrared. We observe eight eclipses of KELT-1b with CHEOPS (CHaracterising ExOPlanet Satellite) to measure its dayside brightness temperature in the bluest passband observed so far, and model the CHEOPS photometry jointly with the existing optical and NIR photometry from TESS, LBT, CFHT, and Spitzer. Our modelling leads to a self-consistent dayside spectrum for KELT-1b covering the CHEOPS, TESS, H , Ks, and Spitzer IRAC 3.6 and 4.5 ${\mu}$m bands, where our TESS, H , Ks, and Spitzer band estimates largely agree with the previous studies, but we discover a strong discrepancy between the CHEOPS and TESS bands. The CHEOPS observations yield a higher photometric precision than the TESS observations, but do not show a significant eclipse signal, while a deep eclipse is detected in the TESS band. The derived TESS geometric albedo of $0.36^{+0.12}_{-0.13}$ is difficult to reconcile with a CHEOPS geometric albedo that is consistent with zero because the two passbands have considerable overlap. Variability in cloud cover caused by the transport of transient nightside clouds to the dayside could provide an explanation for reconciling the TESS and CHEOPS geometric albedos, but this hypothesis needs to be tested by future observations., Comment: Accepted to A&A

Published
2022
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63. TOI-836: A super-Earth and mini-Neptune transiting a nearby K-dwarf

Author

Hawthorn, Faith, Bayliss, Daniel, Wilson, Thomas G., Bonfanti, Andrea, Adibekyan, Vardan, Alibert, Yann, Sousa, Sérgio G., Collins, Karen A., Bryant, Edward M., Osborn, Ares, Armstrong, David J., Abe, Lyu, Acton, Jack S., Addison, Brett C., Agabi, Karim, Alonso, Roi, Alves, Douglas R., Anglada-Escudé, Guillem, Bárczy, Tamas, Barclay, Thomas, Barrado, David, Barros, Susana C. C., Baumjohann, Wolfgang, Bendjoya, Philippe, Benz, Willy, Bieryla, Allyson, Bonfils, Xavier, Bouchy, François, Brandeker, Alexis, Broeg, Christopher, Brown, David J. A., Burleigh, Matthew R., Buttu, Marco, Cabrera, Juan, Caldwell, Douglas A., Casewell, Sarah L., Charbonneau, David, Charnoz, Sébastian, Cloutier, Ryan, Cameron, Andrew Collier, Collins, Kevin I., Conti, Dennis M., Crouzet, Nicolas, Czismadia, Szilárd, Davies, Melvyn B., Deleuil, Magali, Delgado-Mena, Elisa, Delrez, Laetitia, Demangeon, Olivier D. S., Demory, Brice-Olivier, Dransfield, Georgina, Dumusque, Xavier, Egger, Jo Ann, Ehrenreich, David, Eigmüller, Philipp, Erickson, Anders, Essack, Zahra, Fortier, Andrea, Fossati, Luca, Fridlund, Malcolm, Günther, Maximilian N., Güdel, Manuel, Gandolfi, Davide, Gillard, Harvey, Gillon, Michaël, Gnilka, Crystal, Goad, Michael R., Goeke, Robert F., Guillot, Tristan, Hadjigeorghiou, Andreas, Hellier, Coel, Henderson, Beth A., Heng, Kevin, Hooton, Matthew J., Horne, Keith, Howell, Steve B., Hoyer, Sergio, Irwin, Jonathan M., Jenkins, James S., Jenkins, Jon M., Jensen, Eric L. N., Kane, Stephen R., Kendall, Alicia, Kielkopf, John F., Kiss, Laszlo L., Lacedelli, Gaia, Laskar, Jacques, Latham, David W., Etangs, Alain Lecavalier des, Leleu, Adrien, Lendl, Monika, Lillo-Box, Jorge, Lovis, Christophe, Mékarnia, Djamel, Massey, Bob, Masters, Tamzin, Maxted, Pierre F. L., Nascimbeni, Valerio, Nielsen, Louise D., O'Brien, Sean M., Olofsson, Göran, Osborn, Hugh P., Pagano, Isabella, Pallé, Enric, Persson, Carina M., Piotto, Giampaolo, Plavchan, Peter, Pollacco, Don, Queloz, Didier, Ragazzoni, Roberto, Rauer, Heike, Ribas, Ignasi, Ricker, George, Ségransan, Damien, Salmon, Sébastien, Santerne, Alexandre, Santos, Nuno C., Scandariato, Gaetano, Schmider, François-Xavier, Schwarz, Richard P., Seager, Sara, Shporer, Avi, Simon, Attila E., Smith, Alexis M. S., Srdoc, Gregor, Steller, Manfred, Suarez, Olga, Szabó, Gyula M., Teske, Johanna, Thomas, Nicolas, Tilbrook, Rosanna H., Triaud, Amaury H. M. J., Udry, Stéphane, Van Grootel, Valérie, Walton, Nicholas, Wang, Sharon X., Wheatley, Peter J., Winn, Joshua N., Wittenmyer, Robert A., and Zhang, Hui

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present the discovery of two exoplanets transiting TOI-836 (TIC 440887364) using data from TESS Sector 11 and Sector 38. TOI-836 is a bright ($T = 8.5$ mag), high proper motion ($\sim\,200$ mas yr$^{-1}$), low metallicity ([Fe/H]$\approx\,-0.28$) K-dwarf with a mass of $0.68\pm0.05$ M$_{\odot}$ and a radius of $0.67\pm0.01$ R$_{\odot}$. We obtain photometric follow-up observations with a variety of facilities, and we use these data-sets to determine that the inner planet, TOI-836 b, is a $1.70\pm0.07$ R$_{\oplus}$ super-Earth in a 3.82 day orbit, placing it directly within the so-called 'radius valley'. The outer planet, TOI-836 c, is a $2.59\pm0.09$ R$_{\oplus}$ mini-Neptune in an 8.60 day orbit. Radial velocity measurements reveal that TOI-836 b has a mass of $4.5\pm0.9$ M$_{\oplus}$ , while TOI-836 c has a mass of $9.6\pm2.6$ M$_{\oplus}$. Photometric observations show Transit Timing Variations (TTVs) on the order of 20 minutes for TOI-836 c, although there are no detectable TTVs for TOI-836 b. The TTVs of planet TOI-836 c may be caused by an undetected exterior planet.

Published
2022
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64. The stable climate of KELT-9b

Author

Jones, K. D., Morris, B. M., Demory, B. -O., Heng, K., Hooton, M. J., Billot, N., Ehrenreich, D., Hoyer, S., Simon, A. E., Lendl, M., Demangeon, O. D. S., Sousa, S. G., Bonfanti, A., Wilson, T. G., Salmon, S., Csizmadia, Sz., Parviainen, H., Bruno, G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Bonfils, X., Brandeker, A., Broeg, C., Cabrera, J., Charnoz, S., Cameron, A. Collier, Davies, M. B., Deleuil, M., Deline, A., Delrez, L., Erikson, A., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Isaak, K. G., Kiss, L. L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Reimers, C., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Van Grootel, V., Walter, I., Walton, N. A., and Jungo, W. Wang

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Even among the most irradiated gas giants, so-called ultra-hot Jupiters, KELT-9b stands out as the hottest planet thus far discovered with a dayside temperature of over 4500K. At these extreme irradiation levels, we expect an increase in heat redistribution efficiency and a low Bond albedo owed to an extended atmosphere with molecular hydrogen dissociation occurring on the planetary dayside. We present new photometric observations of the KELT-9 system throughout 4 full orbits and 9 separate occultations obtained by the 30cm space telescope CHEOPS. The CHEOPS bandpass, located at optical wavelengths, captures the peak of the thermal emission spectrum of KELT-9b. In this work we simultaneously analyse CHEOPS phase curves along with public phase curves from TESS and Spitzer to infer joint constraints on the phase curve variation, gravity-darkened transits, and occultation depth in three bandpasses, as well as derive 2D temperature maps of the atmosphere at three different depths. We find a day-night heat redistribution efficiency of $\sim$0.3 which confirms expectations of enhanced energy transfer to the planetary nightside due to dissociation and recombination of molecular hydrogen. We also calculate a Bond albedo consistent with zero. We find no evidence of variability of the brightness temperature of the planet, excluding variability greater than 1% (1$\sigma$)., Comment: 21 pages, 9 figures, accepted for publication in A&A

Published
2022
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65. Two-year cardio-pulmonary follow-up after severe COVID-19: a prospective study

Author

Faverio, Paola, Paciocco, Giuseppe, Tassistro, Elena, Rebora, Paola, Rossi, Emanuela, Monzani, Anna, Tundo, Marta, Milano, Chiara, Messa, Martina, Marocchi, Raffaele, Pesci, Alberto, Foti, Giuseppe, Squillace, Nicola, Cogliandro, Viola, Lettino, Maddalena, Strepparava, Maria Grazia, Bellelli, Giuseppe, Ferrarese, Carlo, Valsecchi, Maria Grazia, Bonfanti, Paolo, and Luppi, Fabrizio

Published
2024
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66. A comparative study using insulin pump therapy and continuous glucose monitoring in newly diagnosed very young children with type 1 diabetes: it is possible to bend the curve of HbA1c

Author

Castorani, Valeria, Favalli, Valeria, Rigamonti, Andrea, Frontino, Giulio, Di Tonno, Raffaella, Morotti, Elisa, Sandullo, Federica, Scialabba, Francesco, Arrigoni, Francesca, Dionisi, Benedetta, Foglino, Riccardo, Morosini, Camilla, Olivieri, Gabriele, Barera, Graziano, Meschi, Franco, and Bonfanti, Riccardo

Published
2023
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67. A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067

Author

Luque, R., Osborn, H. P., Leleu, A., Pallé, E., Bonfanti, A., Barragán, O., Wilson, T. G., Broeg, C., Cameron, A. Collier, Lendl, M., Maxted, P. F. L., Alibert, Y., Gandolfi, D., Delisle, J.-B., Hooton, M. J., Egger, J. A., Nowak, G., Lafarga, M., Rapetti, D., Twicken, J. D., Morales, J. C., Carleo, I., Orell-Miquel, J., Adibekyan, V., Alonso, R., Alqasim, A., Amado, P. J., Anderson, D. R., Anglada-Escudé, G., Bandy, T., Bárczy, T., Barrado Navascues, D., Barros, S. C. C., Baumjohann, W., Bayliss, D., Bean, J. L., Beck, M., Beck, T., Benz, W., Billot, N., Bonfils, X., Borsato, L., Boyle, A. W., Brandeker, A., Bryant, E. M., Cabrera, J., Carrazco-Gaxiola, S., Charbonneau, D., Charnoz, S., Ciardi, D. R., Cochran, W. D., Collins, K. A., Crossfield, I. J. M., Csizmadia, Sz., Cubillos, P. E., Dai, F., Davies, M. B., Deeg, H. J., Deleuil, M., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B.-O., Ehrenreich, D., Erikson, A., Esparza-Borges, E., Falk, B., Fortier, A., Fossati, L., Fridlund, M., Fukui, A., Garcia-Mejia, J., Gill, S., Gillon, M., Goffo, E., Gómez Maqueo Chew, Y., Güdel, M., Guenther, E. W., Günther, M. N., Hatzes, A. P., Helling, Ch., Hesse, K. M., Howell, S. B., Hoyer, S., Ikuta, K., Isaak, K. G., Jenkins, J. M., Kagetani, T., Kiss, L. L., Kodama, T., Korth, J., Lam, K. W. F., Laskar, J., Latham, D. W., Lecavelier des Etangs, A., Leon, J. P. D., Livingston, J. H., Magrin, D., Matson, R. A., Matthews, E. C., Mordasini, C., Mori, M., Moyano, M., Munari, M., Murgas, F., Narita, N., Nascimbeni, V., Olofsson, G., Osborne, H. L. M., Ottensamer, R., Pagano, I., Parviainen, H., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Quinn, S. N., Quirrenbach, A., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Redfield, S., Ribas, I., Ricker, G. R., Rudat, A., Sabin, L., Salmon, S., Santos, N. C., Scandariato, G., Schanche, N., Schlieder, J. E., Seager, S., Ségransan, D., Shporer, A., Simon, A. E., Smith, A. M. S., Sousa, S. G., Stalport, M., Szabó, Gy. M., Thomas, N., Tuson, A., Udry, S., Vanderburg, A. M., Van Eylen, V., Van Grootel, V., Venturini, J., Walter, I., Walton, N. A., Watanabe, N., Winn, J. N., and Zingales, T.

Published
2023
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70. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Andrea Lombardi, Simone Villa, Marta Colaneri, Giovanni Scaglione, Francesca Bai, Benedetta Varisco, Valeria Bono, Antonio Vena, Chiara Dentone, Chiara Russo, Mauro Tettamanti, Giulia Renisi, Giulia Viero, Cecilia Azzarà, Marco Mantero, Flora Peyvandi, Matteo Bassetti, Giulia Marchetti, Antonio Muscatello, Alessandro Nobili, Andrea Gori, Alessandra Bandera, Silvano Bosari, Luigia Scudeller, Giuliana Fusetti, Laura Rusconi, Silvia Dell’Orto, Daniele Prati, Luca Valenti, Silvia Giovannelli, Maria Manunta, Giuseppe Lamorte, Francesca Ferarri, Andrea Gori., Davide Mangioni, Laura Alagna, Giorgio Bozzi, Andrea Lombardi., Riccardo Ungaro, Giuseppe Ancona, Marco Mussa, Bianca Veronica Mariani, Matteo Bolis, Nathalie Iannotti, Serena Ludovisi, Agnese Comelli, Simona Biscarini, Valeria Castelli, Emanuele Palomba, Marco Fava, Carlo Alberto Peri, Paola Saltini, Teresa Itri, Valentina Ferroni, Valeria Pastore, Roberta Massafra, Arianna Liparoti, Toussaint Muheberimana, Alessandro Giommi, Rosaria Bianco, Grazia Eliana Chitani, Chiara Bobbio, Irene De Matteis, Angelo Bianchi Bonomi, Roberta Gualtierotti, Barbara Ferrari, Raffaella Rossio, Nadia Boasi, Erica Pagliaro, Costanza Massimo, Michele De Caro, Andrea Giachi, Nicola Montano, Barbara Vigone, Chiara Bellocchi, Angelica Carandina, Elisa Fiorelli, Valerie Melli, Eleonora Tobaldini, Francesco Blasi, Stefano Aliberti, Maura Spotti, Leonardo Terranova, Sofia Misuraca, Alice D’Adda, Silvia Della Fiore, Marta Di Pasquale, Marco Mantero., Martina Contarini, Margherita Ori, Letizia Morlacchi, Valeria Rossetti, Andrea Gramegna, Maria Pappalettera, Mirta Cavallini, Agata Buscemi, Marco Vicenzi, Irena Rota, Giorgio Costantino, Monica Solbiati, Ludovico Furlan, Marta Mancarella, Giulia Colombo, Giorgio Colombo, Alice Fanin, Mariele Passarella, Valter Monzani, Ciro Canetta, Angelo Rovellini, Laura Barbetta, Filippo Billi, Christian Folli, Silvia Accordino, Diletta Maira, Cinzia Maria Hu, Irene Motta, Natalia Scaramellini, Anna Ludovica Fracanzani, Rosa Lombardi, Annalisa Cespiati, Matteo Cesari, Tiziano Lucchi, Marco Proietti, Laura Calcaterra, Clara Mandelli, Carlotta Coppola, Arturo Cerizza, Antonio Maria Pesenti, Giacomo Grasselli, Alessandro Galazzi, Alessandro Nobili., Igor Monti, Alessia Antonella Galbussera, Ernesto Crisafulli, Domenico Girelli, Alessio Maroccia, Daniele Gabbiani, Fabiana Busti, Alice Vianello, Marta Biondan, Filippo Sartori, Paola Faverio, Alberto Pesci, Stefano Zucchetti, Paolo Bonfanti, Marianna Rossi, Ilaria Beretta, Anna Spolti, Sergio Harari, Davide Elia, Roberto Cassandro, Antonella Caminati, Francesco Cipollone, Maria Teresa Guagnano, Damiano D’Ardes, Ilaria Rossi, Francesca Vezzani, Antonio Spanevello, Francesca Cherubino, Dina Visca, Marco Contoli, Alberto Papi, Luca Morandi, Nicholas Battistini, Guido Luigi Moreo, Pasqualina Iannuzzi, Daniele Fumagalla, and Sara Leone

Subjects
Vaccination, Breakthrough infection, SARS-COV-2, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson’s Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised with COVID-19 in Northern Italy. Our results suggest that COVID-19 vaccination has a protective role in individuals with higher risk profiles, especially regarding the need for ICU admission. These findings contribute to our understanding of SARS-CoV-2 infection outcomes among vaccinated individuals and emphasise the importance of vaccination in preventing severe disease, particularly in those countries with lower first-booster uptake rates.

Published
2024
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71. ENHANCING TERRESTRIAL POINT CLOUDS USING UPSAMPLING STRATEGY: FIRST OBSERVATION AND TEST ON FARO FLASH TECHNOLOGY

Author

G. Sammartano, G. Patrucco, M. Avena, C. Bonfanti, and A. Spanò

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Nowadays 3D digitization through the combination or hybridization of different sensors, with the final aim of accelerating the phases of data acquisition and storage, develops user friendly and robotics systems, making efficient the operator role. New technologies as Hybrid Reality Capture™ (HRC), with Flash Technology (FARO Tech.) certainly fits into this market trend, and it is characterized by rapid acquisition, involving 3D scanning data with panoramic images contribution. The system is still under patent, and nothing is yet released on the technology. This research presents the analysis and discussion of results based on the raw and processed data related to the new FARO system. The assumption – based on the information declared by the manufacturer (FARO, 2023) – is that the new colored Flash scans are faster and denser than scans of the same resolution obtained using traditional static scanning method, due to the crucial contribution of the PanoCam data and resolution on which the upsampling strategy is based. An evaluation based on detailed analysis of the upsampling results is reported, delivering that the surface point density exponentially decreases with the distance and with the ray incidence inclination. A comparison with a mobile mapping technology is finally presented and discussed.

Published
2024
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72. The HD 93963 A transiting system: A 1.04d super-Earth and a 3.65 d sub-Neptune discovered by TESS and CHEOPS

Author

Serrano, L. M., Gandolfi, D., Hoyer, S., Brandeker, A., Hooton, M. J., Sousa, S., Murgas, F., Ciardi, D. R., Howell, S. B., Benz, W., Billot, N., Florén, H. -G., Bekkelien, A., Bonfanti, A., Krenn, A., Mustill, A. J., Wilson, T. G., Osborn, H., Parviainen, H., Heidari, N., Pallé, E., Fridlund, M., Adibekyan, V., Fossati, L., Deleuil, M., Knudstrup, E., Collins, K. A., Lam, K. W. F., Grziwa, S., Salmon, S., Albrecht, S. H., Alibert, Y., Alonso, R., Anglada-Escudé, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Bieryla, A., Bonfils, X., Boyd, P. T., Broeg, C., Cabrera, J., Charnoz, S., Chazelas, B., Christiansen, J. L., Cameron, A. Collier, Cortés-Zuleta, P., Csizmadia, Sz., Davies, M. B., Deline, A., Delrez, L., Demangeon, O. D. S., Demory, B. -O., Dunlavey, A., Ehrenreich, D., Erikson, A., Fortier, A., Fukui, A., Garai, Z., Gillon, M., Güdel, M., Hébrard, G., Heng, K., Huang, C. X., Isaak, K. G., Jenkins, J. M., Kiss, L. L., Laskar, J., Latham, D. W., Etangs, A. Lecavelier des, Lendl, M., Levine, A. M., Lovis, C., Lund, M. B., Magrin, D., Maxted, P. F. L., Narita, N., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pessanha, A. C. S. V., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Ricker, G., Rowden, P., Santos, N. C., Scandariato, G., Seager, S., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Twicken, J. D., Udry, S., Ulmer, B., Van Grootel, V., Vanderspek, R., Viotto, V., and Walton, N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present the discovery of two small planets transiting HD 93963A (TOI-1797), a G0\,V star (M$_*$=1.109\,$\pm$\,0.043\,M$_\odot$, R$_*$=1.043\,$\pm$\,0.009\,R$_\odot$) in a visual binary system. We combined TESS and CHEOPS space-borne photometry with data from MuSCAT 2, `Alopeke, PHARO, TRES, FIES, and SOPHIE. We validated and spectroscopically confirmed the outer transiting planet HD 93963 Ac, a sub-Neptune with an orbital period of P$_c \approx$ 3.65 d, reported as a TESS object of interest (TOI) shortly after the release of Sector 22 data. HD 93963 Ac has a mass of M$_c = 19.2 \pm 4.1$ M$_{\oplus}$ and a radius of R$_c = 3.228 \pm 0.059$ R$_{\oplus}$, implying a mean density of $\rho_c=3.1\pm0.7$ gcm$^{-3}$. The inner object, HD 93963 Ab, is a validated 1.04 d ultra-short period (USP) transiting super-Earth that we discovered in the TESS light curve and that was not listed as a TOI, owing to the low significance of its signal (TESS signal-to-noise ratio $\approx$ 6.7, TESS $+$ CHEOPS combined transit depth D$_b=141.5 \pm 8.5$ ppm). We intensively monitored the star with CHEOPS by performing nine transit observations to confirm the presence of the inner planet and validate the system. HD 93963 Ab is the first small (R$_b = 1.35 \pm 0.042$ R$_{\oplus}$) USP planet discovered and validated by TESS and CHEOPS. Unlike planet c, HD 93963 Ab is not significantly detected in our radial velocities (M$_b = 7.8 \pm 3.2$ M$_{\oplus}$). We also discovered a linear trend in our Doppler measurements, suggesting the possible presence of a long-period outer planet. With a V-band magnitude of 9.2, HD 93963 A is among the brightest stars known to host a USP planet, making it one of the most favourable targets for precise mass measurement via Doppler spectroscopy and an important laboratory to test formation, evolution, and migration models of planetary systems hosting ultra-short period planets., Comment: Accepted in Astronomy & Astrophysics

Published
2022
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73. Accounting for stellar activity signals in radial-velocity data by using Change Point Detection techniques

Author

Simola, U., Bonfanti, A., Dumusque, X., Cisewski-Kehe, J., Kaski, S., and Corander, J.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Statistics - Applications
Abstract

Active regions on the photosphere of a star have been the major obstacle for detecting Earth-like exoplanets using the radial velocity (RV) method. A commonly employed solution for addressing stellar activity is to assume a linear relationship between the RV observations and the activity indicators along the entire time series, and then remove the estimated contribution of activity from the variation in RV data (overall correction method). However, since active regions evolve on the photosphere over time, correlations between the RV observations and the activity indicators will correspondingly be anisotropic. We present an approach that recognizes the RV locations where the correlations between the RV and the activity indicators significantly change in order to better account for variations in RV caused by stellar activity. The proposed approach uses a general family of statistical breakpoint methods, often referred to as change point detection (CPD) algorithms; several implementations of which are available in R and python. A thorough comparison is made between the breakpoint-based approach and the overall correction method. To ensure wide representativity, we use measurements from real stars that have different levels of stellar activity and whose spectra have different signal-to-noise ratios. When the corrections for stellar activity are applied separately to each temporal segment identified by the breakpoint method, the corresponding residuals in the RV time series are typically much smaller than those obtained by the overall correction method. Consequently, the generalized Lomb-Scargle periodogram contains a smaller number of peaks caused by active regions. The CPD algorithm is particularly effective when focusing on active stars with long time series, such as alpha Cen B., Comment: 31 pages, 18 Figures

Published
2022
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74. Toxic and signaling effects of the anaesthetic lidocaine on rice cultured cells

Author

Lucia Sylvain Bonfanti, Delphine Arbelet-Bonnin, Frédéric Filaine, Christophe Lalanne, Aurélien Renault, Patrice Meimoun, Patrick Laurenti, Etienne Grésillon, and François Bouteau

Subjects
anaesthesia, calcium, lidocaine, osmotic stress, programmed cell death, rice, Plant ecology, QK900-989, Biology (General), QH301-705.5
Abstract

Most studies on anesthesia focus on the nervous system of mammals due to their interest in medicine. The fact that any life form can be anaesthetised is often overlooked although anesthesia targets ion channel activities that exist in all living beings. This study examines the impact of lidocaine on rice (Oryza sativa). It reveals that the cellular responses observed in rice are analogous to those documented in animals, encompassing direct effects, the inhibition of cellular responses, and the long-distance transmission of electrical signals. We show that in rice cells, lidocaine has a cytotoxic effect at a concentration of 1%, since it induces programmed reactive oxygen species (ROS) and caspase-like-dependent cell death, as already demonstrated in animal cells. Additionally, lidocaine causes changes in membrane ion conductance and induces a sharp reduction in electrical long-distance signaling following seedlings leaves burning. Finally, lidocaine was shown to inhibit osmotic stress-induced cell death and the regulation of Ca2+ homeostasis. Thus, lidocaine treatment in rice and tobacco (Nicotiana benthamiana) seedlings induces not only cellular but also systemic effects similar to those induced in mammals.

Published
2024
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76. Looking for the Signs

Author

Bonfanti, Annarita and Dan, Roberto

Subjects
Bronze bowls. Cuneiform inscriptions. Karmir-blur. Minua. Urartu, Languages and literature of Eastern Asia, Africa, Oceania, PL1-8844
Abstract

Among the most representative objects not only of metallurgy, but of the Urartian kingship itself, there is a rather conspicuous group of bronze bowls bearing short inscriptions in cuneiform. These texts allow to attribute the ownership of these objects to a series of Urartian rulers. Since 2022, a new project has been underway to study comprehensively these objects, most of which are stored in the History Museum of Armenia. The present article deals with two bowls referable to king Minua, son of Išpuini, one of which, unpublished, bears an unfinished inscription. A reconstruction of this inscription is given based on microscopic analysis of the epigraph preparation marks.

Published
2024
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77. A systematic review on the role of therapist characteristics in the treatment of eating disorders

Author

Gaia Albano, Arianna Teti, Arianna Scrò, Rubinia Celeste Bonfanti, Lucia Fortunato, and Gianluca Lo Coco

Subjects
Eating disorders, therapist characteristics, empathy, expertise, systematic review, Psychology, BF1-990
Abstract

Treating patients with eating disorders can be challenging for therapists, as it requires the establishment of a strong therapeutic relationship. According to the literature, therapist characteristics may influence intervention outcomes. The aim of this systematic review was to identify and synthesize existing literature on therapist interpersonal characteristics that could affect psychotherapy relationship or outcomes in the context of eating disorder treatment from both patients’ and therapists’ perspectives. We conducted a systematic search using electronic databases and included both qualitative and quantitative studies from 1980 until July 2023. Out of the 1230 studies screened, 38 papers met the inclusion criteria and were included in the systematic review. The results indicate that patients reported therapist’s warmth, empathic understanding, a supportive attitude, expertise in eating disorders, and self-disclosure as positive characteristics. Conversely, a lack of empathy, a judgmental attitude, and insufficient expertise were reported as therapist negative characteristics, which could have a detrimental impact on treatment outcome. Few studies have reported therapist’s perceptions of their own personal characteristics which could have an impact on treatment. Therapists reported that empathy and supportiveness, optimism, and previous eating disorder experience were positive characteristics. Conversely, clinician anxiety, a judgmental attitude, and a lack of objectivity were reported as negative characteristics that therapists felt could hinder treatment. This systematic review offers initial evidence on the personal characteristics of therapists that may affect the treatment process and outcomes when working with patients with eating disorders.

Published
2024
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78. Case report: A case of Rabson–Mendenhall syndrome: long-term follow-up and therapeutic management with empagliflozin

Author

R. Foglino, F. Barbetti, E. Morotti, V. Castorani, A. Rigamonti, G. Frontino, G. Barera, and R. Bonfanti

Subjects
Rabson–Mendenhall syndrome, severe insulin resistance, sodium–glucose cotransporter 2 inhibitors, glycemic control, insulin receptor mutations, metabolic syndrome, Genetics, QH426-470
Abstract

Background: Rabson–Mendenhall syndrome (RMS), a rare disorder characterized by severe insulin resistance due to biallelic loss-of-function variants of the insulin receptor gene (INSR), presents therapeutic challenges (OMIM: 262190). This case study explores the efficacy of adjunctive therapy with sodium–glucose cotransporter 2 inhibitors (SGLT2is) in the management of RMS in an 11-year-old male patient with compound heterozygous pathogenic variants of INSR.Methods: Despite initial efforts to regulate glycemia with insulin therapy followed by metformin treatment, achieving stable glycemic control presented a critical challenge, characterized by persistent hyperinsulinism and variable fluctuations in glucose levels. Upon the addition of empagliflozin to metformin, notable improvements in glycated hemoglobin (HbA1c) and time in range (TIR) were observed over a 10-month period.Results: After 10 months of treatment, empagliflozin therapy led to a clinically meaningful reduction in HbA1c levels, decreasing from 8.5% to 7.1%, along with an improvement in TIR from 47% to 74%. Furthermore, regular monitoring effectively averted normoglycemic ketoacidosis, a rare complication associated with SGLT2 inhibitor therapy.Conclusion: This case highlights the potential of SGLT2i as adjunctive therapy in RMS management, particularly in stabilizing glycemic variability. However, further research is warranted to elucidate the long-term efficacy and safety of this therapeutic approach in RMS and similar insulin resistance syndromes.

Published
2024
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79. Carbonate precipitation and phosphate trapping by microbialite isolates from an alkaline insular lake (Bagno dell'Acqua, Pantelleria Island, Italy)

Author

Cristina Mazzoni, Agnese Piacentini, Letizia Di Bella, Luca Aldega, Cristina Perinelli, Aida Maria Conte, Michela Ingrassia, Tania Ruspandini, Andrea Bonfanti, Benedetta Caraba, Francesco Giuseppe Falese, Francesco Latino Chiocci, and Stefano Fazi

Subjects
biomineralization, alkaline lake, microbialites, pantelleria, phosphate trapping, hazenite, Microbiology, QR1-502
Abstract

The Bagno dell'Acqua lake is characterized by CO2 emissions, alkaline waters (pH = 9) and Eh values which indicate strongly oxidizing conditions. A typical feature of the lake is the presence of actively growing microbialites rich in calcium carbonates and silica precipitates. Mineralogy, petrography and morphology analyses of the microbialites were coupled with the analysis of the microbial community, combining molecular and cultivation approaches. The DNA sequencing revealed distinct patterns of microbial diversity, showing pronounced differences between emerged and submerged microbialite, with the upper layer of emerged samples exhibiting the most distinctive composition, both in terms of prokaryotes and eukaryotes. In particular, the most representative phyla in the microbial community were Proteobacteria, Actinobacteriota, and Bacteroidota, while Cyanobacteria were present only with an average of 5%, with the highest concentration in the submerged intermediate layer (12%). The role of microorganisms in carbonate mineral formation was clearly demonstrated as most of the isolates were able to precipitate calcium carbonate and five of them were characterized at molecular level. Interestingly, when microbial isolates were cultivated only in filtered water, the precipitation of hazenite was observed (up to 85%), opening new prospective in P (phosphate) recovery from P depleted environments.

Published
2024
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80. 609 Pregnancy outcomes in systemic lupus erythematosus (SLE): data from a multiethnic, multinational Latin American cohort

Author

Graciela S Alarcón, Eduardo Kerzberg, Rosana Quintana, Guillermo Pons-Estel, Guillermo Berbotto, Veronica Saurit, Eloisa Bonfa, Loreto Massardo, Ana Malvar, Francinne Machado Ribeiro, Carlos Abud-Mendoza, Bernardo Pons-Estel, Manuel F Ugarte-Gil, Fernando Cavalcanti, Federico Zazzetti, Miguel A Saavedra, Urbano Sbarigia, Oscar Neira, Marina Scolnik, Alvaro Danza, Mercedes García, Ignacio Garcia-De La Torre, Romina Nieto, Cecilia Pisoni, Sabrina Porta, Anne Stevens, Eduardo Borba, Paula Alba, Vicente Juarez, Graciela Gomez, Carlos Enrique Toro Gutierrez, Luis Humberto Silveira Torre, Odirlei Monticielo, Nílzio Da Silva, Jorge Antonio Esquivel Valerio, Rosa Maria Serrano Morales, Lucia Hernández, Verónica Inés Bellomio, Gustavo Aroca Martínez, Andrés Cadena Bonfanti, Gerardo Quintana Lopez, Mario Javier Moreno Alvarez, Isabel Acosta-Colman, Astrid Paats, Claudia Mora, Diana Fernández Ávila, Carmen Funes Soaje, Edgard Reis Neto, Iris Guerra Herrera, Carlos Cañas, Margarita Portela, Hilda Fragoso Loyo, Armando Calvo Quiroz, Roberto Muñoz Louis, Ricardo Robaina, and Ashley Orillion

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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81. Dynamics of viral DNA shedding and culture viral DNA positivity in different clinical samples collected during the 2022 mpox outbreak in Lombardy, Italy

Author

Antonio Piralla, Davide Mileto, Alberto Rizzo, Guglielmo Ferrari, Federica Giardina, Stefano Gaiarsa, Greta Petazzoni, Micol Bianchi, Federica Salari, Fiorenza Bracchitta, Josè Camilla Sammartino, Alessandro Ferrari, Gloria Gagliardi, Alessandro Mancon, Claudio Fenizia, Mara Biasin, Francesca Rovida, Stefania Paolucci, Elena Percivalle, Alessandra Lombardi, Valeria Micheli, Silvia Nozza, Antonella Castagna, Davide Moschese, Spinello Antinori, Andrea Gori, Paolo Bonfanti, Roberto Rossotti, Antonella D'Arminio Monforte, Federica Attanasi, Marcello Tirani, Danilo Cereda, Fausto Baldanti, Maria Rita Gismondo, Miriam Cutrera, Marianna Cuomo, Federica De Poli, Giulia Campanini, Antonino Maria Guglielmo Pitrolo, Elizabeth Iskandar, Irene Cassaniti, Raffaele Bruno, Giuliano Rizzardini, Massimo Puoti, Francesco Castelli, Laura Corsico, Andrea Giacomelli, Giacomo Pozza, Giacomo Casalini, Angelo Raccagni, Bendetta Trentacapilli, Costanza Bertoni, Elena Bruzzesi, Caterina Candela, Daniele Tesoro, Giovanni Mule, Alessandra Bandera, Antonio Muscatello Bianca Mariani, Manuel Maffeo, Riccardo Vecchio, and Sara Piccinelli

Subjects
Mpox virus, Molecular epidemiology, Next generation sequencing, Re-Emerging virus, Multiple samples, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Background: Mpox virus (MPXV) has recently spread outside of sub-Saharan Africa. This large multicentre study was conducted in Lombardy, the most densely populated Italian region accounting for more than 40% of Italian cases. The present study aims to: i) evaluate the presence and the shedding duration of MPXV DNA in different body compartments correlating the MPXV viability with the time to onset of symptoms; ii) provide evidence of MPXV persistence in different body compartment as a source of infection and iii) characterize the MPXV evolution by whole genome sequencing (WGS) during the outbreak occurred in Italy. Material and methods: The study included 353 patients with a laboratory-confirmed diagnosis of MPXV infection screened in several clinical specimens in the period May 24th - September 1st, 2022. Viral isolation was attempted from different biological matrices and complete genome sequencing was performed for 61 MPXV strains. Results: MPXV DNA detection was more frequent in the skin (94.4%) with the longest median time of viral clearance (16 days). The actively-replicating virus in cell culture was obtained for 123/377 (32.6%) samples with a significant higher viral quantity on isolation positive samples (20 vs 31, p

Published
2024
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82. Uncovering the true periods of the young sub-Neptunes orbiting TOI-2076

Author

Osborn, Hugh P., Bonfanti, Andrea, Gandolfi, Davide, Hedges, Christina, Leleu, Adrien, Fortier, Andrea, Futyan, David, Gutermann, Pascal, Maxted, Pierre F. L., Borsato, Luca, Collins, Karen A., da Silva, J. Gomes, Chew, Yilen Gómez Maqueo, Hooton, Matthew J., Lendl, Monika, Parviainen, Hannu, Salmon, Sébastien, Schanche, Nicole, Serrano, Luisa M., Sousa, Sergio G., Tuson, Amy, Ulmer-Moll, Solène, Van Grootel, Valerie, Wells, R. D., Wilson, Thomas G., Alibert, Yann, Alonso, Roi, Anglada, Guillem, Asquier, Joel, Navascues, David Barrado y, Baumjohann, Wolfgang, Beck, Thomas, Benz, Willy, Biondi, Federico, Bonfils, Xavier, Bouchy, Francois, Brandeker, Alexis, Broeg, Christopher, Bárczy, Tamas, Barros, S. C. C., Cabrera, Juan, Charnoz, Sébastien, Cameron, Andrew Collier, Csizmadia, Szilard, Davies, Melvyn B., Deleuil, Magali, Delrez, Laetitia, Demory, Brice-Olivier, Ehrenreich, David, Erikson, Anders, Fossati, Luca, Fridlund, Malcolm, Gillon, Michaël, Gómez-Muñoz, M. A., Güdel, Manuel, Heng, Kevin, Hoyer, Sergio, Isaak, Kate G., Kiss, Laszlo, Laskar, Jacques, Etangs, Alain Lecavelier des, Lovis, Christophe, Magrin, Demetrio, Malavolta, Luca, McCormac, James, Nascimbeni, Valerio, Olofsson, Göran, Ottensamer, Roland, Pagano, Isabella, Pallé, Enric, Peter, Gisbert, Piazza, Daniele, Piotto, Giampaolo, Pollacco, Don, Queloz, Didier, Ragazzoni, Roberto, Rando, Nicola, Rauer, Heike, Reimers, Christian, Ribas, Ignasi, Demangeon, Olivier D. S., Smith, Alexis M. S., Sabin, L., Santos, Nuno, Scandariato, Gaetano, Schroffenegger, U., Schwarz, Rick P., Shporer, Avi, Simon, Attila E., Steller, Manfred, Szabó, Gyula M., Ségransan, Damien, Thomas, Nicolas, Udry, Stéphane, Walter, Ingo, and Walton, Nicholas

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context: TOI-2076 is a transiting three-planet system of sub-Neptunes orbiting a bright (G = 8.9 mag), young ($340\pm80$ Myr) K-type star. Although a validated planetary system, the orbits of the two outer planets were unconstrained as only two non-consecutive transits were seen in TESS photometry. This left 11 and 7 possible period aliases for each. Aims: To reveal the true orbits of these two long-period planets, precise photometry targeted on the highest-probability period aliases is required. Long-term monitoring of transits in multi-planet systems can also help constrain planetary masses through TTV measurements. Methods: We used the MonoTools package to determine which aliases to follow, and then performed space-based and ground-based photometric follow-up of TOI-2076 c and d with CHEOPS, SAINT-EX, and LCO telescopes. Results: CHEOPS observations revealed a clear detection for TOI-2076 c at $P=21.01538^{+0.00084}_{-0.00074}$ d, and allowed us to rule out three of the most likely period aliases for TOI-2076 d. Ground-based photometry further enabled us to rule out remaining aliases and confirm the $P=35.12537\pm0.00067$ d alias. These observations also improved the radius precision of all three sub-Neptunes to $2.518\pm0.036$, $3.497\pm0.043$, and $3.232\pm0.063$ $R_\oplus$. Our observations also revealed a clear anti-correlated TTV signal between planets b and c likely caused by their proximity to the 2:1 resonance, while planets c and d appear close to a 5:3 period commensurability, although model degeneracy meant we were unable to retrieve robust TTV masses. Their inflated radii, likely due to extended H-He atmospheres, combined with low insolation makes all three planets excellent candidates for future comparative transmission spectroscopy with JWST., Comment: 18 pages, 7 figure, 8 tables. Accepted for publication in Astronomy & Astrophysics. Photometry available on CDS/Vizier. Python package presented for modelling duotransiting planet candidates available at https://github.com/hposborn/MonoTools. Modelling & figure-creation code available at https://github.com/hposborn/TOI2076

Published
2022
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83. Transit timing variations of AU Microscopii b and c

Author

Szabó, Gy. M., Garai, Z., Brandeker, A., Gandolfi, D., Wilson, T. G., Deline, A., Olofsson, G., Fortier, A., Queloz, D., Borsato, L., Kiefer, F., Etangs, A. Lecavelier des, Lendl, M., Serrano, L. M., Sulis, S., Moll, S. Ulmer, Van Grootel, V., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Bonfanti, A., Bonfils, X., Broeg, C., Cabrera, J., Charnoz, S., Cameron, A. Collier, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O., Demory, B. -O., Ehrenreich, D., Erikson, A., Fossati, L., Fridlund, M., Gillon, M., Güdel, M., Heng, K., Hoyer, S., Isaak, K. G., Kiss, L. L., Laskar, J., Lovis, C., Magrin, D., Maxted, P. F. L., Mecina, M., Nascimbeni, V., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Sarajlic, M., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Sousa, S., Steller, M., Thomas, N., Udry, S., Verrecchia, F., Walton, N., and Wolter, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Here we report large-amplitude transit timing variations (TTVs) for AU\,Microcopii b and c as detected in combined TESS (2018, 2020) and CHEOPS (2020, 2021) transit observations. AU Mic is a young planetary system with a debris disk and two transiting warm Neptunes. A TTV on the order of several minutes was previously reported for AU Mic b, which was suggested to be an outcome of mutual perturbations between the planets in the system. In 2021, we observed AU Mic b (five transits) and c (three transits) with the CHEOPS space telescope to follow-up the TTV of AU Mic b and possibly detect a TTV for AU Mic c. When analyzing TESS and CHEOPS 2020--2021 measurements together, we find that a prominent TTV emerges with a full span of ~23 minutes between the two TTV extrema. Assuming that the period change results from a periodic process - such as mutual perturbations - we demonstrate that the times of transits in the summer of 2022 are expected to be 30--85 minutes later than predicted by the available linear ephemeris., Comment: 10 pages, 6 figures, accepted as an A&A Letter

Published
2022
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85. Predicting the failure of two-dimensional silica glasses

Author

Font-Clos, Francesc, Zanchi, Marco, Hiemer, Stefan, Bonfanti, Silvia, Guerra, Roberto, Zaiser, Michael, and Zapperi, Stefano

Subjects
Condensed Matter - Materials Science, Condensed Matter - Disordered Systems and Neural Networks, Physics - Data Analysis, Statistics and Probability
Abstract

Being able to predict the failure of materials based on structural information is a fundamental issue with enormous practical and industrial relevance for the monitoring of devices and components. Thanks to recent advances in deep learning, accurate failure predictions are becoming possible even for strongly disordered solids, but the sheer number of parameters used in the process renders a physical interpretation of the results impossible. Here we address this issue and use machine learning methods to predict the failure of simulated two dimensional silica glasses from their initial undeformed structure. We then exploit Gradient-weighted Class Activation Mapping (Grad-CAM) to build attention maps associated with the predictions, and we demonstrate that these maps are amenable to physical interpretation in terms of topological defects and local potential energies. We show that our predictions can be transferred to samples with different shape or size than those used in training, as well as to experimental images. Our strategy illustrates how artificial neural networks trained with numerical simulation results can provide interpretable predictions of the behavior of experimentally measured structures., Comment: 41 pages 13 figures

Published
2022
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86. Investigating the architecture and internal structure of the TOI-561 system planets with CHEOPS, HARPS-N and TESS

Author

Lacedelli, G., Wilson, T. G., Malavolta, L., Hooton, M. J., Cameron, A. Collier, Alibert, Y., Mortier, A., Bonfanti, A., Haywood, R. D., Hoyer, S., Piotto, G., Bekkelien, A., Vanderburg, A. M., Benz, W., Dumusque, X., Deline, A., López-Morales, M., Borsato, L., Rice, K., Fossati, L., Latham, D. W., Brandeker, A., Poretti, E., Sousa, S. G., Sozzetti, A., Salmon, S., Burke, C. J., Van Grootel, V., Fausnaugh, M. M., Adibekyan, V., Huang, C. X., Osborn, H. P., Mustill, A. J., Pallé, E., Bourrier, V., Nascimbeni, V., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Billot, N., Bonfils, X., Broeg, C., Buchhave, L. A., Cabrera, J., Charnoz, S., Cosentino, R., Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demangeon, O., Demory, B. -O., Ehrenreich, D., Erikson, A., Esparza-Borges, E., Florén, H. -G., Fortier, A., Fridlund, M., Futyan, D., Gandolfi, D., Ghedina, A., Gillon, M., Güdel, M., Gutermann, P., Harutyunyan, A., Heng, K., Isaak, K. G., Jenkins, J. M., Kiss, L., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Magrin, D., Marafatto, L., Fiorenzano, A. F. Martinez, Maxted, P. F. L., Mayor, M., Micela, G., Molinari, E., Murgas, F., Narita, N., Olofsson, G., Ottensamer, R., Pagano, I., Pasetti, A., Pedani, M., Pepe, F. A., Peter, G., Phillips, D. F., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Ratti, F., Rauer, H., Ribas, I., Santos, N. C., Sasselov, D., Scandariato, G., Seager, S., Ségransan, D., Serrano, L. M., Simon, A. E., Smith, A. M. S., Steinberger, M., Steller, M., Szabó, Gy., Thomas, N., Twicken, J. D., Udry, S., Walton, N., and Winn, J. N.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present a precise characterization of the TOI-561 planetary system obtained by combining previously published data with TESS and CHEOPS photometry, and a new set of $62$ HARPS-N radial velocities (RVs). Our joint analysis confirms the presence of four transiting planets, namely TOI-561 b ($P = 0.45$ d, $R = 1.42$ R$_\oplus$, $M = 2.0$ M$_\oplus$), c ($P = 10.78$ d, $R = 2.91$ R$_\oplus$, $M = 5.4$ M$_\oplus$), d ($P = 25.7$ d, $R = 2.82$ R$_\oplus$, $M = 13.2$ M$_\oplus$) and e ($P = 77$ d, $R = 2.55$ R$_\oplus$, $M = 12.6$ M$_\oplus$). Moreover, we identify an additional, long-period signal ($>450$ d) in the RVs, which could be due to either an external planetary companion or to stellar magnetic activity. The precise masses and radii obtained for the four planets allowed us to conduct interior structure and atmospheric escape modelling. TOI-561 b is confirmed to be the lowest density ($\rho_{\rm b} = 3.8 \pm 0.5$ g cm$^{-3}$) ultra-short period (USP) planet known to date, and the low metallicity of the host star makes it consistent with the general bulk density-stellar metallicity trend. According to our interior structure modelling, planet b has basically no gas envelope, and it could host a certain amount of water. In contrast, TOI-561 c, d, and e likely retained an H/He envelope, in addition to a possibly large water layer. The inferred planetary compositions suggest different atmospheric evolutionary paths, with planets b and c having experienced significant gas loss, and planets d and e showing an atmospheric content consistent with the original one. The uniqueness of the USP planet, the presence of the long-period planet TOI-561 e, and the complex architecture make this system an appealing target for follow-up studies., Comment: 22 pages, 19 figures. Accepted for publication in MNRAS

Published
2022
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87. The atmosphere and architecture of WASP-189 b probed by its CHEOPS phase curve

Author

Deline, A., Hooton, M. J., Lendl, M., Morris, B., Salmon, S., Olofsson, G., Broeg, C., Ehrenreich, D., Beck, M., Brandeker, A., Hoyer, S., Sulis, S., Van Grootel, V., Bourrier, V., Demangeon, O., Demory, B. -O., Heng, K., Parviainen, H., Serrano, L. M., Singh, V., Bonfanti, A., Fossati, L., Kitzmann, D., Sousa, S. G., Wilson, T. G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, T., Bekkelien, A., Benz, W., Billot, N., Bonfils, X., Cabrera, J., Charnoz, S., Cameron, A. Collier, van Damme, C. Corral, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., de Roche, T., Erikson, A., Fortier, A., Fridlund, M., Futyan, D., Gandolfi, D., Gillon, M., Güdel, M., Gutermann, P., Hasiba, J., Isaak, K. G., Kiss, L., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Munari, M., Nascimbeni, V., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Walter, I., and Walton, N.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Gas giants orbiting close to hot and massive early-type stars can reach dayside temperatures that are comparable to those of the coldest stars. These "ultra-hot Jupiters" have atmospheres made of ions and atomic species from molecular dissociation and feature strong day-to-night temperature gradients. Photometric observations at different orbital phases provide insights on the planet atmospheric properties. We analyse the photometric observations of WASP-189 acquired with the instrument CHEOPS to derive constraints on the system architecture and the planetary atmosphere. We implement a light curve model suited for asymmetric transit shape caused by the gravity-darkened photosphere of the fast-rotating host star. We also model the reflective and thermal components of the planetary flux, the effect of stellar oblateness and light-travel time on transit-eclipse timings, the stellar activity and CHEOPS systematics. From the asymmetric transit, we measure the size of the ultra-hot Jupiter WASP-189 b, $R_p=1.600^{+0.017}_{-0.016}\,R_J$, with a precision of 1%, and the true orbital obliquity of the planetary system $\Psi_p=89.6\pm1.2\deg$ (polar orbit). We detect no significant hotspot offset from the phase curve and obtain an eclipse depth $\delta_\text{ecl}=96.5^{+4.5}_{-5.0}\,\text{ppm}$, from which we derive an upper limit on the geometric albedo: $A_g<0.48$. We also find that the eclipse depth can only be explained by thermal emission alone in the case of extremely inefficient energy redistribution. Finally, we attribute the photometric variability to the stellar rotation, either through superficial inhomogeneities or resonance couplings between the convective core and the radiative envelope., Comment: 25 pages, 16 figures, 5 tables (including the appendix); published in A&A

Published
2022
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88. A pair of Sub-Neptunes transiting the bright K-dwarf TOI-1064 characterised with CHEOPS

Author

Wilson, Thomas G., Goffo, Elisa, Alibert, Yann, Gandolfi, Davide, Bonfanti, Andrea, Persson, Carina M., Cameron, Andrew Collier, Fridlund, Malcolm, Fossati, Luca, Korth, Judith, Benz, Willy, Deline, Adrien, Florén, Hans-Gustav, Guterman, Pascal, Adibekyan, Vardan, Hooton, Matthew J., Hoyer, Sergio, Leleu, Adrien, Mustill, Alexander James, Salmon, Sébastien, Sousa, Sérgio G., Suarez, Olga, Abe, Lyu, Agabi, Abdelkrim, Alonso, Roi, Anglada, Guillem, Asquier, Joel, Bárczy, Tamas, Navascues, David Barrado y, Barros, Susana C. C., Baumjohann, Wolfgang, Beck, Mathias, Beck, Thomas, Billot, Nicolas, Bonfils, Xavier, Brandeker, Alexis, Broeg, Christopher, Bryant, Edward M., Burleigh, Matthew R., Buttu, Marco, Cabrera, Juan, Charnoz, Sébastien, Ciardi, David R., Cloutier, Ryan, Cochran, William D., Collins, Karen A., Colón, Knicole D., Crouzet, Nicolas, Csizmadia, Szilard, Davies, Melvyn B., Deleuil, Magali, Delrez, Laetitia, Demangeon, Olivier, Demory, Brice-Olivier, Dragomir, Diana, Dransfield, Georgina, Ehrenreich, David, Erikson, Anders, Fortier, Andrea, Gan, Tianjun, Gill, Samuel, Gillon, Michaël, Gnilka, Crystal L., Grieves, Nolan, Grziwa, Sascha, Güdel, Manuel, Guillot, Tristan, Haldemann, Jonas, Heng, Kevin, Horne, Keith, Howell, Steve B., Isaak, Kate G., Jenkins, Jon M., Jensen, Eric L. N., Kiss, Laszlo, Lacedelli, Gaia, Lam, Kristine, Laskar, Jacques, Latham, David W., Etangs, Alain Lecavelier des, Lendl, Monika, Lester, Kathryn V., Levine, Alan M., Livingston, John, Lovis, Christophe, Luque, Rafael, Magrin, Demetrio, Marie-Sainte, Wenceslas, Maxted, Pierre F. L., Mayo, Andrew W., McLean, Brian, Mecina, Marko, Mékarnia, Djamel, Nascimbeni, Valerio, Nielsen, Louise D., Olofsson, Göran, Osborn, Hugh P., Osborne, Hannah L. M., Ottensamer, Roland, Pagano, Isabella, Pallé, Enric, Peter, Gisbert, Piotto, Giampaolo, Pollacco, Don, Queloz, Didier, Ragazzoni, Roberto, Rando, Nicola, Rauer, Heike, Redfield, Seth, Ribas, Ignasi, Ricker, George R., Rieder, Martin, Santos, Nuno C., Scandariato, Gaetano, Schmider, François-Xavier, Schwarz, Richard P., Scott, Nicholas J., Seager, Sara, Ségransan, Damien, Serrano, Luisa Maria, Simon, Attila E., Smith, Alexis M. S., Steller, Manfred, Stockdale, Chris, Szabó, Gyula, Thomas, Nicolas, Ting, Eric B., Triaud, Amaury H. M. J., Udry, Stéphane, Van Eylen, Vincent, Van Grootel, Valérie, Vanderspek, Roland K., Viotto, Valentina, Walton, Nicholas, and Winn, Joshua N.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We report the discovery and characterisation of a pair of sub-Neptunes transiting the bright K-dwarf TOI-1064 (TIC 79748331), initially detected in TESS photometry. To characterise the system, we performed and retrieved CHEOPS, TESS, and ground-based photometry, HARPS high-resolution spectroscopy, and Gemini speckle imaging. We characterise the host star and determine $T_{\rm eff, \star}=4734\pm67$ K, $R_{\star}=0.726\pm0.007$ $R_{\odot}$, and $M_{\star}=0.748\pm0.032$ $M_{\odot}$. We present a novel detrending method based on PSF shape-change modelling and demonstrate its suitability to correct flux variations in CHEOPS data. We confirm the planetary nature of both bodies and find that TOI-1064 b has an orbital period of $P_{\rm b}=6.44387\pm0.00003$ d, a radius of $R_{\rm b}=2.59\pm0.04$ $R_{\oplus}$, and a mass of $M_{\rm b}=13.5_{-1.8}^{+1.7}$ $M_{\oplus}$, whilst TOI-1064 c has an orbital period of $P_{\rm c}=12.22657^{+0.00005}_{-0.00004}$ d, a radius of $R_{\rm c}=2.65\pm0.04$ $R_{\oplus}$, and a 3$\sigma$ upper mass limit of 8.5 ${\rm M_{\oplus}}$. From the high-precision photometry we obtain radius uncertainties of $\sim$1.6%, allowing us to conduct internal structure and atmospheric escape modelling. TOI-1064 b is one of the densest, well-characterised sub-Neptunes, with a tenuous atmosphere that can be explained by the loss of a primordial envelope following migration through the protoplanetary disc. It is likely that TOI-1064 c has an extended atmosphere due to the tentative low density, however further RVs are needed to confirm this scenario and the similar radii, different masses nature of this system. The high-precision data and modelling of TOI-1064 b are important for planets in this region of mass-radius space, and it allows us to identify a trend in bulk density-stellar metallicity for massive sub-Neptunes that may hint at the formation of this population of planets., Comment: 30 pages, 24 figures, 6 tables including the Appendix; accepted for publication in MNRAS

Published
2022
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90. Efficacy and Safety of Reparixin in Patients with Severe COVID-19 Pneumonia: A Phase 3, Randomized, Double-Blind Placebo-Controlled Study

Author

Piemonti, Lorenzo, Landoni, Giovanni, Voza, Antonio, Puoti, Massimo, Gentile, Ivan, Coppola, Nicola, Nava, Stefano, Mattei, Alessia, Marinangeli, Franco, Marchetti, Giulia, Bonfanti, Paolo, Mastroianni, Claudio Maria, Bassetti, Matteo, Crisafulli, Ernesto, Grossi, Paolo Antonio, Zangrillo, Alberto, Desai, Antonio, Merli, Marco, Foggia, Maria, Carpano, Marco, Schiavoni, Lorenzo, D’Arminio Monforte, Antonella, Bisi, Luca, Russo, Gianluca, Busti, Fabiana, Rovelli, Cristina, Perrotta, Elisabetta, Goisis, Giovanni, Gavioli, Elizabeth M., Toya, Sophie, De Pizzol, Maria, Mantelli, Flavio, Allegretti, Marcello, and Minnella, Enrico Maria

Published
2023
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95. An Italian case series' description of thiamine responsive megaloblastic anemia syndrome: importance of early diagnosis and treatment

Author

Francesca Di Candia, Valentina Di Iorio, Nadia Tinto, Riccardo Bonfanti, Claudio Iovino, Francesco Maria Rosanio, Ludovica Fedi, Fernanda Iafusco, Francesca Arrigoni, Rita Malesci, Francesca Simonelli, Andrea Rigamonti, Adriana Franzese, and Enza Mozzillo

Subjects
Nonautoimmune diabetes, Optic atrophy, Sensorineural deafness, Thiamine-responsive megaloblastic anemia syndrome, Case series, Pediatrics, RJ1-570
Abstract

Abstract Background Individuals with thiamine-responsive megaloblastic anemia (TRMA) mainly manifest macrocytic anemia, sensorineural deafness, ocular complications, and nonautoimmune diabetes. Macrocytic anemia and diabetes may be responsive to high-dosage thiamine treatment, in contrast to sensorineural deafness. Little is known about the efficacy of thiamine treatment on ocular manifestations. Cases presentation Our objective is to report data from four Italian TRMA patients: in Cases 1, 2 and 3, the diagnosis of TRMA was made at 9, 14 and 27 months. In 3 out of 4 subjects, thiamine therapy allowed both normalization of hyperglycemia, with consequent insulin suspension, and macrocytic anemia. In all Cases, thiamine therapy did not resolve the clinical manifestation of deafness. In Cases 2 and 3, follow-up showed no blindness, unlike Case 4, in which treatment was started for megaloblastic anemia at age 7 but was increased to high doses only at age 25, when the genetic diagnosis of TRMA was performed. Conclusions Early institution of high-dose thiamine supplementation seems to prevent the development of retinal changes and optic atrophy in TRMA patients. The spectrum of clinical manifestations is broad, and it is important to describe known Cases to gain a better understanding of this rare disease.

Published
2023
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96. Analysis of Early Science observations with the CHaracterising ExOPlanets Satellite (CHEOPS) using pycheops

Author

Maxted, P. F. L., Ehrenreich, D., Wilson, T. G., Alibert, Y., Cameron, A. Collier, Hoyer, S., Sousa, S. G., Olofsson, G., Bekkelien, A., Deline, A., Delrez, L., Bonfanti, A., Borsato, L., Alonso, R., Escudé, G. Anglada, Barrado, D., Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Biondi, F., Bonfils, X., Brandeker, A., Broeg, C., Bárczy, T., Cabrera, J., Charnoz, S., Van Damme, C. Corral, Csizmadia, Sz., Davies, M. B., Deleuil, M., Demangeon, O. D. S., Demory, B. -O., Erikson, A., Florén, H. G., Fortier, A., Fossati, L., Fridlund, M., Futyan, D., Gandolfi, D., Gillon, M., Guedel, M., Guterman, P., Heng, K., Isaak, K. G., Kiss, L., Laskar, J., Etangs, A. Lecavelier des, Lendl, M., Lovis, C., Magrin, D., Nascimbeni, V., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Pozuelos, F. J., Queloz, D., Ragazzoni, R., Rando, N., Rauer, H., Reimers, C., Ribas, I., Salmon, S., Santos, N. C., Scandariato, G., Simon, A. E., Smith, A. M. S., Steller, M., Swayne, M. I., Szabó, Gy. M., Ségransan, D., Thomas, N., Udry, S., Van Grootel, V., and Walton, N. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

CHEOPS(CHaracterising ExOPlanet Satellite) is an ESA S-class mission that observes bright stars at high cadence from low-Earth orbit. The main aim of the mission is to characterize exoplanets that transit nearby stars using ultrahigh precision photometry. Here we report the analysis of transits observed by CHEOPS during its Early Science observing programme for four well-known exoplanets: GJ436b, HD106315b, HD97658b and GJ1132b. The analysis is done using pycheops, an open-source software package we have developed to easily and efficiently analyse CHEOPS light curve data using state-of-the-art techniques that are fully described herein. We show that the precision of the transit parameters measured using CHEOPS is comparable to that from larger space telescopes such as Spitzer Space Telescope and Kepler. We use the updated planet parameters from our analysis to derive new constraints on the internal structure of these four exoplanets., Comment: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review

Published
2021
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97. Developing a Prototype of a Mechanical Ventilator Controller from Requirements to Code with ASMETA

Author

Bombarda, Andrea, Bonfanti, Silvia, Gargantini, Angelo, and Riccobene, Elvinia

Subjects
Computer Science - Formal Languages and Automata Theory, Computer Science - Software Engineering
Abstract

Rigorous development processes aim to be effective in developing critical systems, especially if failures can have catastrophic consequences for humans and the environment. Such processes generally rely on formal methods, which can guarantee, thanks to their mathematical foundation, model preciseness, and properties assurance. However, they are rarely adopted in practice. In this paper, we report our experience in using the Abstract State Machine formal method and the ASMETA framework in developing a prototype of the control software of the MVM (Mechanical Ventilator Milano), a mechanical lung ventilator that has been designed, successfully certified, and deployed during the COVID-19 pandemic. Due to time constraints and lack of skills, no formal method was applied for the MVM project. However, we here want to assess the feasibility of developing (part of) the ventilator by using a formal method-based approach. Our development process starts from a high-level formal specification of the system to describe the MVM main operation modes. Then, through a sequence of refined models, all the other requirements are captured, up to a level in which a C++ implementation of a prototype of the MVM controller is automatically generated from the model, and tested. Along the process, at each refinement level, different model validation and verification activities are performed, and each refined model is proved to be a correct refinement of the previous level. By means of the MVM case study, we evaluate the effectiveness and usability of our formal approach., Comment: In Proceedings AppFM 2021, arXiv:2111.07538

Published
2021
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98. The Impact of Diet on Body Composition in a Cohort of Pediatric and Adult Patients with Maple Syrup Urine Disease

Author

Roberta Pretese, Cristina Bonfanti, Martha Caterina Faraguna, Marialetizia Fantasia, Viola Crescitelli, Silvia Barzaghi, Mara Botti, Giulia Mezzanotti, and Serena Gasperini

Subjects
maple syrup urine disease, branched-chain amino acids, body composition, hypoproteic diet, osteopenia, bone mineral density, Nutrition. Foods and food supply, TX341-641
Abstract

The treatment for Maple Syrup Urine Disease (MSUD) consists of a hypoproteic diet with integration therapy to limit leucine intake, ensuring adequate energy, macronutrients, and micronutrients to prevent catabolism and promote anabolism. We conducted a retrospective cross-sectional study at the Metabolic Rare Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. Patients with MSUD who were over 3 years old, not treated with liver transplantation, and who provided written consent, were included. The study aimed to describe the dietary treatment of patients with MSUD, evaluate growth data, and analyze the effect of a low-protein and semi-synthetic diet on body composition. Data on height, weight, BMI, waist circumference, food intake, physical activity, and DEXA scans were collected. Thirteen subjects (11 classic MSUD, 2 intermediate MSUD) were included, of which 5 < 18 years old. Results indicated that patients with MSUD follow a balanced diet and have body compositions like healthy subjects in terms of fat and lean mass. A high incidence of osteopenia was observed from a young age, with a positive correlation between protein intake and lean mass and a negative correlation between BCAA-free mixture consumption and bone mineral density z-score. The study highlights the positive effects and potential consequences of the semi-synthetic diet on the body composition of patients with MSUD. A similar study involving all Italian metabolic centers treating MSUD is recommended.

Published
2024
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