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304 results on '"Cipolletta, Edoardo"'

51. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

De Angelis, Rossella, primary, Ferri, Clodoveo, additional, Giuggioli, Dilia, additional, Bajocchi, Gianluigi, additional, Dagna, Lorenzo, additional, Bellando-Randone, Silvia, additional, Zanframundo, Giovanni, additional, Foti, Rosario, additional, Cacciapaglia, Fabio, additional, Cuomo, Giovanna, additional, Ariani, Alarico, additional, Rosato, Edoardo, additional, Lepri, Gemma, additional, Girelli, Francesco, additional, Riccieri, Valeria, additional, Zanatta, Elisabetta, additional, Bosello, Silvia Laura, additional, Cavazzana, Ilaria, additional, Ingegnoli, Francesca, additional, De Santis, Maria, additional, Murdaca, Giuseppe, additional, Abignano, Giuseppina, additional, Romeo, Nicoletta, additional, Della Rossa, Alessandra, additional, Caminiti, Maurizio, additional, Iuliano, Anna Maria, additional, Ciano, Giovanni, additional, Beretta, Lorenzo, additional, Bagnato, Gianluca, additional, Lubrano, Ennio, additional, De Andres, Ilenia, additional, Giollo, Alessandro, additional, Saracco, Marta, additional, Agnes, Cecilia, additional, Cipolletta, Edoardo, additional, Lumetti, Federica, additional, Spinella, Amelia, additional, Magnani, Luca, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Codullo, Veronica, additional, Visalli, Elisa, additional, Di Vico, Claudio, additional, Gigante, Antonietta, additional, Pellagrino, Greta, additional, Pigatto, Erika, additional, Lazzaroni, Maria-Grazia, additional, Franceschini, Franco, additional, Generali, Elena, additional, Mennillo, Gianna, additional, Barsotti, Simone, additional, Mariano, Giuseppa Pagano, additional, Furini, Federica, additional, Vultaggio, Licia, additional, Parisi, Simone, additional, Peroni, Clara Lisa, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Landolfi, Gianpiero, additional, Scirè, Carlo Alberto, additional, Bianchi, Gerolamo, additional, Fusaro, Enrico, additional, Sebastiani, Gian Domenico, additional, Govoni, Marcello, additional, D'Angelo, Salvatore, additional, Cozzi, Franco, additional, Guiducci, Serena, additional, Doria, Andrea, additional, Salvarani, Carlo, additional, Iannone, Florenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2023
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54. Reliability assessment of ultrasound muscle echogenicity in patients with rheumatic diseases: Results of a multicenter international web-based study

Author

Di Matteo, Andrea, primary, Moscioni, Erica, additional, Lommano, Maria Giovanna, additional, Cipolletta, Edoardo, additional, Smerilli, Gianluca, additional, Farah, Sonia, additional, Airoldi, Carla, additional, Aydin, Sibel Zehra, additional, Becciolini, Andrea, additional, Bonfiglioli, Karina, additional, Carotti, Marina, additional, Carrara, Greta, additional, Cazenave, Tomas, additional, Corradini, Davide, additional, Cosatti, Micaela Ana, additional, de Agustin, Juan Josè, additional, Destro Castaniti, Giulia Maria, additional, Di Carlo, Marco, additional, Di Donato, Eleonora, additional, Di Geso, Luca, additional, Elliott, Ashley, additional, Fodor, Daniela, additional, Francioso, Francesca, additional, Gabba, Alessandra, additional, Hernández-Díaz, Cristina, additional, Horvath, Rudolf, additional, Hurnakova, Jana, additional, Jesus, Diogo, additional, Marin, Josefina, additional, Martire, Maria Victoria, additional, Mashadi Mirza, Riccardo, additional, Massarotti, Marco, additional, Musca, Alice Andreea, additional, Nair, Jagdish, additional, Okano, Tadashi, additional, Papalopoulos, Ioannis, additional, Rosa, Javier, additional, Rosemffet, Marcos, additional, Rovisco, João, additional, Rozza, Davide, additional, Salaffi, Fausto, additional, Scioscia, Crescenzio, additional, Scirè, Carlo Alberto, additional, Tamas, Maria-Magdalena, additional, Tanimura, Shun, additional, Ventura-Rios, Lucio, additional, Villota-Eraso, Catalina, additional, Villota, Orlando, additional, Voulgari, Paraskevi V., additional, Vreju, Florentin Ananu, additional, Vukatana, Gentiana, additional, Hereter, Johana Zacariaz, additional, Zanetti, Anna, additional, Grassi, Walter, additional, and Filippucci, Emilio, additional

Published
2023
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57. Imaging of the peripheral nervous system in nociplastic pain: An ultrasound study in patients with fibromyalgia.

Author

Di Carlo, Marco, Bianchi, Benedetta, Cipolletta, Edoardo, Farah, Sonia, Filippucci, Emilio, and Salaffi, Fausto

Subjects
PERIPHERAL nervous system, FIBROMYALGIA, VAGUS nerve, CERVICAL plexus, ONE-way analysis of variance
Abstract

Background and Purpose: Although fibromyalgia (FM) is considered a central sensitization syndrome, studies investigating peripheral nerves in this condition are not available. The primary objective of this study is to investigate the sonographic changes (ie, increased cross‐sectional area [CSA]), of peripheral nerves in patients with FM compared to healthy controls. The secondary objective is to identify potential clinical correlations associated with increased CSA in patients with FM. Methods: In this cross‐sectional observational study, consecutive female patients with FM underwent sonographic assessment using a standardized scanning protocol. The CSA of seven nerves was measured bilaterally at 11 anatomic sites by an experienced sonographer. Differences in CSA of nerves were compared with those of healthy subjects by one‐way analysis of variance. Patients underwent clinimetric evaluation aimed at investigating disease severity, neuropathic pain features, depression, anxiety, fatigue, and autonomic symptoms to explore the possible correlation between CSA and clinical features. Results: Forty‐seven patients and 20 healthy controls were enrolled. Differences in terms of increased CSA between patients and healthy controls were identified at multiple levels, mainly at the level of the sural nerve, vagus nerve, and sixth cervical nerve root (for all, p <.001). Sonographic findings, however, did not correlate with the clinical features explored. Conclusions: Patients with FM show higher CSA of nerves than healthy subjects. The increased CSA is most evident at the sural nerve, vagus nerve, and sixth cervical nerve root. Ultrasound, a relatively easy‐to‐use technique, could identify morphological changes, in peripheral nervous structures in patients with FM. [ABSTRACT FROM AUTHOR]

Published
2023
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59. In patients with acute mono/oligoarthritis, a targeted ultrasound scanning protocol shows great accuracy for the diagnosis of gout and CPPD

Author

Cipolletta, Edoardo, primary, Filippucci, Emilio, additional, Abhishek, Abhishek, additional, Di Battista, Jacopo, additional, Smerilli, Gianluca, additional, Di Carlo, Marco, additional, Silveri, Ferdinando, additional, De Angelis, Rossella, additional, Salaffi, Fausto, additional, Grassi, Walter, additional, and Di Matteo, Andrea, additional

Published
2022
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63. Peripheral Microangiopathy Changes in Pulmonary Arterial Hypertension Related to Systemic Sclerosis: Data From a Multicenter Observational Study

Author

Giuggioli, Dilia, primary, Riccieri, Valeria, additional, Cipolletta, Edoardo, additional, Del Papa, Nicoletta, additional, Ingegnoli, Francesca, additional, Spinella, Amelia, additional, Pellegrino, Greta, additional, Risa, Anna Maria, additional, de Pinto, Marco, additional, Papa, Silvia, additional, Armentaro, Giuseppe, additional, and De Angelis, Rossella, additional

Published
2022
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64. Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review

Author

De Angelis, Rossella, Di Battista, Jacopo, Smerilli, Gianluca, Cipolletta, Edoardo, Di Carlo, Marco, and Salaffi, Fausto

Subjects
anti-RNA polymerase III antibodies, systemic sclerosis, cancer, Case Report, skin and connective tissue diseases, silicone breast implant
Abstract

Some case reports and small case series of patients with silicone breast implant (SBI) have reported the development of systemic sclerosis (SSc) many years later, despite conflicting evidence of this association in the literature. Recently, patients with SSc and anti-RNA polymerase III antibodies positivity have been associated with previous silicone implants and/or breast cancer, showing clinical features that differ from the classic SSc, such as rapid and diffuse cutaneous involvement and scleroderma renal crisis (SRC). The specific autoimmune reaction is not yet fully understood, although knowledge in this regard is increasing. We describe a case that can support these previous observations, strengthening this association which must be taken into account. Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.

Published
2020

67. In patients with acute mono/oligoarthritis, a targeted ultrasound scanning protocol shows great accuracy for the diagnosis of gout and CPPD.

Author

Cipolletta, Edoardo, Filippucci, Emilio, Abhishek, Abhishek, Battista, Jacopo Di, Smerilli, Gianluca, Carlo, Marco Di, Silveri, Ferdinando, Angelis, Rossella De, Salaffi, Fausto, Grassi, Walter, and Matteo, Andrea Di

Subjects
*GOUT diagnosis, *ULTRASONIC imaging, *CONFIDENCE intervals, *MANN Whitney U Test, *CHONDROCALCINOSIS, *MEDICAL protocols, *QUALITATIVE research, *DESCRIPTIVE statistics, *CHI-squared test, *ARTHRITIS, *DATA analysis software, *ACUTE diseases, *LONGITUDINAL method
Abstract

Objectives To determine an US scanning protocol with the best accuracy for the diagnosis of gout and CPPD in patients with acute mono/oligo-arthritis of unknown origin. Methods Patients with acute mono/oligo-arthritis in whom a joint aspiration at the most clinically involved joint (target joint) was requested were consecutively enrolled. US was performed in each patient before the arthrocentesis. The accuracy of different US findings and scanning protocols for the diagnosis of gout and CPPD was calculated. Results A total of 161 subjects were included (32 gout patients, 30 CPPD patients and 99 disease-controls). US findings had a high specificity for gout (0.92–0.96) and CPPD (0.90–0.97), while the sensitivity ranged from 0.73 to 0.85 in gout (double contour sign and tophi, respectively) and from 0.60 to 0.90 in CPPD (hyaline and fibrocartilage deposits, respectively). The US assessment of two joints bilaterally (gout: knees, MTP1 joints; CPPD: knees, wrists) plus the target joint had an excellent diagnostic sensitivity (gout: 0.91, CPPD: 0.93) and specificity (gout: 0.91, CPPD: 0.89). This targeted US scanning protocol yielded to higher diagnostic accuracy compared with the US evaluation of the target joint [gout area under the curve (AUC) 0.91 vs 0.84, P  = 0.03; CPPD AUC 0.93 vs 0.84, P  = 0.04] unless the target joint was the knee or the MTP1 joint in gout and the knee or the wrist in CPPD. Conclusions A targeted US scanning protocol of two joints bilaterally plus the target joint showed an excellent accuracy (>90%) for the diagnosis of crystal arthritis in patients with acute mono/oligoarthritis.   A video abstract is available for this article and can be viewed at https://doi.org/10.1093/rheumatology/keac479. [ABSTRACT FROM AUTHOR]

Published
2023
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69. Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance

Author

Di Matteo, Andrea, primary, Smerilli, Gianluca, additional, Cipolletta, Edoardo, additional, Wakefield, Richard J, additional, De Angelis, Rossella, additional, Risa, Anna Maria, additional, Salaffi, Fausto, additional, Farah, Sonia, additional, Villota-Eraso, Catalina, additional, Maccarrone, Vincenzo, additional, Filippucci, Emilio, additional, and Grassi, Walter, additional

Published
2022
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70. Comparison of ultrasound attenuation by calcium pyrophosphate, hydroxyapatite and monosodium urate crystals: a proof-of-concept study

Author

Filippou, Georgios, primary, Pacini, Giovanni, additional, Sirotti, Silvia, additional, Zadory, Matthias, additional, Carboni, Davide, additional, Damiani, Arianna, additional, Fiorentini, Elisa, additional, Cipolletta, Edoardo, additional, Filippucci, Emilio, additional, Froehlich, Johannes M, additional, Sarzi Puttini, Piercarlo, additional, and Becce, Fabio, additional

Published
2022
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71. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study

Author

Di Matteo, Andrea, primary, Cipolletta, Edoardo, additional, Destro Castaniti, Giulia Maria, additional, Smerilli, Gianluca, additional, Airoldi, Carla, additional, Aydin, Sibel Zehra, additional, Becciolini, Andrea, additional, Bonfiglioli, Karina, additional, Bruns, Alessandra, additional, Carrara, Greta, additional, Cazenave, Tomas, additional, Ciapetti, Alessandro, additional, Cosatti, Micaela Ana, additional, de Agustín, Juan José, additional, Di Carlo, Marco, additional, Di Donato, Eleonora, additional, Di Geso, Luca, additional, Duran, Emine, additional, Elliott, Ashley, additional, Estrach, Cristina, additional, Farisogulları, Bayram, additional, Fiorenza, Alessia, additional, Fodor, Daniela, additional, Gabba, Alessandra, additional, Hernández-Díaz, Cristina, additional, Huang, Feng, additional, Hurnakova, Jana, additional, Li, Ling, additional, Jesus, Diogo, additional, Karadag, Omer, additional, Martire, Maria Victoria, additional, Massarotti, Marco, additional, Michelena, Xabier, additional, Musca, Alice Andreea, additional, Nair, Jagdish, additional, Okano, Tadashi, additional, Papalopoulos, Ioannis, additional, Rosemffet, Marcos, additional, Rovisco, João, additional, Rozza, Davide, additional, Salaffi, Fausto, additional, Satulu, Iulia, additional, Scioscia, Crescenzio, additional, Scirè, Carlo Alberto, additional, Sun, Fei, additional, Tamas, Maria-Magdalena, additional, Tanimura, Shun, additional, Ventura-Rios, Lucio, additional, Voulgari, Paraksevi V, additional, Vreju, Florentin Ananu, additional, Vukatana, Gentiana, additional, Wong, Ernest, additional, Yang, Jinshui, additional, Zacariaz Hereter, Johana, additional, Zanetti, Anna, additional, Grassi, Walter, additional, and Filippucci, Emilio, additional

Published
2022
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73. Doppler Signal and Bone Erosions at the Enthesis Are Independently Associated With Ultrasound Joint Erosive Damage in Psoriatic Arthritis

Author

Smerilli, Gianluca, primary, Cipolletta, Edoardo, additional, Destro Castaniti, Giulia Maria, additional, Di Matteo, Andrea, additional, Di Carlo, Marco, additional, Moscioni, Erica, additional, Francioso, Francesca, additional, Mirza, Riccardo Mashadi, additional, Grassi, Walter, additional, and Filippucci, Emilio, additional

Published
2022
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75. Ultrasonography in the prediction of gout flares: a 12-month prospective observational study.

Author

Cipolletta, Edoardo, Abhishek, Abhishek, Battista, Jacopo Di, Grassi, Walter, and Filippucci, Emilio

Subjects
*PREDICTIVE tests, *SCIENTIFIC observation, *CONFIDENCE intervals, *INFLAMMATION, *MULTIVARIATE analysis, *DOPPLER ultrasonography, *DESCRIPTIVE statistics, *URIC acid, *ODDS ratio, *GOUT, *LONGITUDINAL method
Abstract

Objectives To evaluate whether US findings indicating MSU deposits and US-detected inflammation (i.e. power Doppler signal) predict gout flares over 12 months. Methods Gout patients on urate-lowering therapy for at least the preceding 6 months were enrolled consecutively in this 12-month prospective, observational, single-centre study. A nested case–control analysis was performed. Cases were participants with at least one flare in the follow-up period, while controls did not self-report any gout flare. The US assessment included elbows, wrists, second MCP joints, knees, ankles, and first MTP joints. The US findings indicating MSU deposits [i.e. aggregates, double contour (DC) sign and tophi] were identified as present/absent according to the Outcome Measure in Rheumatology definitions. Power Doppler signal was scored semiquantitatively. Summated scores were calculated for each US finding. Results Eighty-one gout participants were enrolled, and 71 completed the study. Thirty (42.3%) of 71 participants experienced at least one flare over 12 months, with a median of 2.0 flares. Cases had a greater US burden of MSU deposits (6.7 ± 4.7 vs 2.9 ± 2.6, P  = 0.01) and power Doppler signal (3.73 ± 3.53 vs 0.82 ± 1.44, P  < 0.01) than controls, at baseline. The baseline US scores indicating MSU deposits and US-detected inflammation were significantly associated with the occurrence (total MSU score, adjusted odds ratio:1.75, 95% CI: 1.26, 2.43; power Doppler score, adjusted odds ratio: 1.63, 95% CI: 1.12, 2.40) and the number (total MSU score, adjusted incidence risk ratio: 1.17, 95% CI: 1.08, 1.26; power Doppler score, adjusted incidence risk ratio: 1.29, 95% CI: 1.19, 1.40) of flares over 12 months in multivariate analyses. Conclusions Baseline US findings indicating MSU deposits and US-detected inflammation are independent predictors of gout flares over 12 months. [ABSTRACT FROM AUTHOR]

Published
2023
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78. Ultrasound subclinical synovitis in anti-CCP-positive at-risk individuals with musculoskeletal symptoms: an important and predictable stage in the rheumatoid arthritis continuum

Author

Di Matteo, Andrea, primary, Duquenne, Laurence, additional, Cipolletta, Edoardo, additional, Nam, Jacqueline L, additional, Garcia-Montoya, Leticia, additional, Wakefield, Richard J, additional, Mahler, Michael, additional, Mankia, Kulveer, additional, and Emery, Paul, additional

Published
2021
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80. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study.

Author

Matteo, Andrea Di, Cipolletta, Edoardo, Castaniti, Giulia Maria Destro, Smerilli, Gianluca, Airoldi, Carla, Aydin, Sibel Zehra, Becciolini, Andrea, Bonfiglioli, Karina, Bruns, Alessandra, Carrara, Greta, Cazenave, Tomas, Ciapetti, Alessandro, Cosatti, Micaela Ana, Agustín, Juan José de, Carlo, Marco Di, Donato, Eleonora Di, Geso, Luca Di, Duran, Emine, Elliott, Ashley, and Estrach, Cristina

Subjects
*RELIABILITY (Personality trait), *RESEARCH, *STATISTICS, *BONES, *CONFIDENCE intervals, *JUVENILE idiopathic arthritis, *ANKYLOSIS, *SPONDYLOARTHROPATHIES, *INTER-observer reliability, *DOPPLER ultrasonography, *DESCRIPTIVE statistics, RESEARCH evaluation
Abstract

Objectives To investigate the reliability of the OMERACT US Task Force definition of US enthesitis in SpA. Methods In this web exercise, based on the evaluation of 101 images and 39 clips of the main entheses of the lower limbs, the elementary components included in the OMERACT definition of US enthesitis in SpA (hypoechoic areas, entheseal thickening, power Doppler signal at the enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres in 15 countries. Inter- and intra-observer reliability of the US components of enthesitis was calculated using Light's kappa, Cohen's kappa, Prevalence And Bias Adjusted Kappa (PABAK) and their 95% CIs. Results Bone erosions and power Doppler signal at the enthesis showed the highest overall inter-reliability [Light's kappa: 0.77 (0.76–0.78), 0.72 (0.71–0.73), respectively; PABAK: 0.86 (0.86–0.87), 0.73 (0.73–0.74), respectively], followed by enthesophytes/calcifications [Light's kappa: 0.65 (0.64–0.65), PABAK: 0.67 (0.67–0.68)]. This was moderate for entheseal thickening [Light's kappa: 0.41 (0.41–0.42), PABAK: 0.41 (0.40–0.42)], and fair for hypoechoic areas [Light's kappa: 0.37 (0.36–0.38); PABAK: 0.37 (0.37–0.38)]. A similar trend was observed in the intra-reliability exercise, although this was characterized by an overall higher degree of reliability for all US elementary components compared with the inter-observer evaluation. Conclusions The results of this multicentre, international, web-based study show a good reliability of the OMERACT US definition of bone erosions, power Doppler signal at the enthesis and enthesophytes/calcifications. The low reliability of entheseal thickening and hypoechoic areas raises questions about the opportunity to revise the definition of these two major components for the US diagnosis of enthesitis. [ABSTRACT FROM AUTHOR]

Published
2022
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81. Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance.

Author

Matteo, Andrea Di, Smerilli, Gianluca, Cipolletta, Edoardo, Wakefield, Richard J, Angelis, Rossella De, Risa, Anna Maria, Salaffi, Fausto, Farah, Sonia, Villota-Eraso, Catalina, Maccarrone, Vincenzo, Filippucci, Emilio, and Grassi, Walter

Subjects
SKELETAL muscle physiology, GRIP strength, SKELETAL muscle, SARCOPENIA, BODY movement, MUSCLE strength, QUADRICEPS muscle, SYSTEMIC lupus erythematosus, EARLY diagnosis
Abstract

Objectives The objectives of this study were (1) to explore US findings for muscle mass, muscle quality and muscle stiffness in SLE patients and healthy subjects; (2) to investigate the relationship between the US muscle findings and physical performance in SLE patients and healthy subjects. Methods Quadriceps muscle thickness was used for assessment of muscle mass, muscle echogenicity (using a visual semi-quantitative scale and grayscale analysis with histograms) for assessment of muscle quality, and point shear-wave elastography (SWE) for assessment of muscle stiffness in 30 SLE patients (without previous/current myositis or neuromuscular disorders) and 15 age-, sex- and BMI-matched healthy subjects. Hand grip strength tests and short physical performance battery (SPPB) tests were carried out in the same populations. Results No difference was observed between SLE patients and healthy subjects for quadriceps muscle thickness (35.2 mm ± s.d. 6.8 vs 34.8 mm ±  s.d. 6.0, respectively, P  = 0.79). Conversely, muscle echogenicity was significantly increased in SLE patients (visual semi-quantitative scale: 1.7 ±  s.d. 1.0 vs 0.3 ±  s.d. 0.5, respectively, P  < 0.01; grayscale analysis with histograms: 87.4 mean pixels ±  s.d. 18.8 vs 70.1 mean pixels ±  s.d. 14.0, respectively, P  < 0.01). Similarly, SWE was significantly lower in SLE patients compared with healthy subjects {1.5 m/s [interquartile range (IQR) 0.3] vs 1.6 m/s (IQR 0.2), respectively, P  = 0.01}. Muscle echogenicity was inversely correlated with grip strength (visual semi-quantitative scale, Rho : –0.47, P  = 0.01; grayscale analysis with histograms, Rho : –0.41, p  < 0.01) and SPPB (visual semi-quantitative scale, Rho : –0.50, P  < 0.01; grayscale analysis with histograms Rho : –0,46, P  < 0.01). Conclusions US assessment of muscle echogenicity and stiffness is useful for the early detection of muscle involvement in SLE patients. [ABSTRACT FROM AUTHOR]

Published
2022
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83. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee:an OMERACT ultrasound study

Author

Filippou, Georgios, Scanu, Anna, Adinolfi, Antonella, Toscano, Carmela, Gambera, Dario, Largo, Raquel, Naredo, Esperanza, Calvo, Emilio, Herrero-Beaumont, Gabriel, Zufferey, Pascal, Bonjour, Christel Madelaine, Maccarter, Daryl K., Makman, Stanley, Weber, Zachary, Figus, Fabiana, Möller, Ingrid, Gutierrez, Marwin, Pineda, Carlos, Clavijo Cornejo, Denise, Garcia, Hector, Ilizaliturri, Victor, Mendoza Torres, Jaime, Pichardo, Raul, Rodriguez Delgado, Luis Carlos, Filippucci, Emilio, Cipolletta, Edoardo, Serban, Teodora, Cirstoiu, Catalin, Vreju, Florentin Ananu, Grecu, Dan, Mouterde, Gaël, Govoni, Marcello, Punzi, Leonardo, Damjanov, Nemanja S., Keen, Helen Isobel, Bruyn, George A.W., Terslev, Lene, D'agostino, Maria Antonietta, Scirè, Carlo Alberto, Iagnocco, Annamaria, Filippou, Georgios, Scanu, Anna, Adinolfi, Antonella, Toscano, Carmela, Gambera, Dario, Largo, Raquel, Naredo, Esperanza, Calvo, Emilio, Herrero-Beaumont, Gabriel, Zufferey, Pascal, Bonjour, Christel Madelaine, Maccarter, Daryl K., Makman, Stanley, Weber, Zachary, Figus, Fabiana, Möller, Ingrid, Gutierrez, Marwin, Pineda, Carlos, Clavijo Cornejo, Denise, Garcia, Hector, Ilizaliturri, Victor, Mendoza Torres, Jaime, Pichardo, Raul, Rodriguez Delgado, Luis Carlos, Filippucci, Emilio, Cipolletta, Edoardo, Serban, Teodora, Cirstoiu, Catalin, Vreju, Florentin Ananu, Grecu, Dan, Mouterde, Gaël, Govoni, Marcello, Punzi, Leonardo, Damjanov, Nemanja S., Keen, Helen Isobel, Bruyn, George A.W., Terslev, Lene, D'agostino, Maria Antonietta, Scirè, Carlo Alberto, and Iagnocco, Annamaria

Abstract

Objective To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard. Methods Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings. Results 11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75% -sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation. Conclusion Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.

Published
2021

85. Correspondence on ‘SARS-CoV-2 vaccine hesitancy among patients with rheumatic and musculoskeletal diseases: a message for rheumatologists’

Author

Smerilli, Gianluca, primary, Cipolletta, Edoardo, additional, Moscioni, Erica, additional, Francioso, Francesca, additional, Risa, Anna Maria, additional, Maccarrone, Vincenzo, additional, Zompa, Davide, additional, Di Matteo, Andrea, additional, Di Carlo, Marco, additional, De Angelis, Rossella, additional, Salaffi, Fausto, additional, Filippucci, Emilio, additional, and Grassi, Walter, additional

Published
2021
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87. Ultrasound subclinical synovitis in anti-CCP-positive at-risk individuals with musculoskeletal symptoms: an important and predictable stage in the rheumatoid arthritis continuum.

Author

Matteo, Andrea Di, Duquenne, Laurence, Cipolletta, Edoardo, Nam, Jacqueline L, Garcia-Montoya, Leticia, Wakefield, Richard J, Mahler, Michael, Mankia, Kulveer, and Emery, Paul

Subjects
MUSCULOSKELETAL system diseases, AUTOANTIBODIES, DISEASE progression, SYNOVITIS, CONFIDENCE intervals, MULTIVARIATE analysis, CONTINUUM of care, RHEUMATOID arthritis, SYMPTOMS, DESCRIPTIVE statistics, PREDICTION models, ODDS ratio
Abstract

Objectives To investigate whether anti-CCP2-positive at-risk individuals with musculoskeletal (MSK) symptoms but without clinical synovitis (CCP2+ at-risk) develop US subclinical synovitis before inflammatory arthritis and if US subclinical synovitis can be predicted. Methods First, US scans of CCP2+ at-risk individuals who developed inflammatory arthritis ('progressors') were reviewed for subclinical synovitis prior to inflammatory arthritis development. Patients in whom the pre-progression US scan was negative but the scan was conducted >6 months before progression were excluded. Subsequently, regression analyses were performed to identify predictors of US synovitis in CCP2+ at-risk individuals without baseline US abnormalities who had one or more longitudinal US scan and a complete dataset. Results US subclinical synovitis was detected in one or more scan in 75 of 97 progressors (77.3%) {median time to inflammatory arthritis development from first evidence of US synovitis 26.5 weeks [interquartile range (IQR) 7–60]}, in whom one or more scan was available, excluding those with a negative scan >6 months from inflammatory arthritis development (n  = 38). In 220 CCP2+ at-risk individuals with normal baseline US scans, who had one or more longitudinal US scan and a complete dataset, US synovitis was detected in 69/220 (31.4%) [median time to first developing US synovitis 56.4 weeks (IQR 33.0–112.0)]. In the multivariable analysis, only anti-CCP3 antibodies were predictive for the development of US synovitis [odds ratio 4.75 (95% CI 1.97, 11.46); P  < 0.01]. Conclusions In anti-CCP2+ at-risk individuals, a stage of subclinical synovitis usually precedes the development of inflammatory arthritis. Anti-CCP2+/CCP3+ individuals without clinical or US subclinical synovitis may represent the optimal window of opportunity for intervention to prevent joint disease. [ABSTRACT FROM AUTHOR]

Published
2022
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95. Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

Author

Filippou, Georgios, primary, Scanu, Anna, additional, Adinolfi, Antonella, additional, Toscano, Carmela, additional, Gambera, Dario, additional, Largo, Raquel, additional, Naredo, Esperanza, additional, Calvo, Emilio, additional, Herrero-Beaumont, Gabriel, additional, Zufferey, Pascal, additional, Bonjour, Christel Madelaine, additional, MacCarter, Daryl K, additional, Makman, Stanley, additional, Weber, Zachary, additional, Figus, Fabiana, additional, Möller, Ingrid, additional, Gutierrez, Marwin, additional, Pineda, Carlos, additional, Clavijo Cornejo, Denise, additional, Garcia, Hector, additional, Ilizaliturri, Victor, additional, Mendoza Torres, Jaime, additional, Pichardo, Raul, additional, Rodriguez Delgado, Luis Carlos, additional, Filippucci, Emilio, additional, Cipolletta, Edoardo, additional, Serban, Teodora, additional, Cirstoiu, Catalin, additional, Vreju, Florentin Ananu, additional, Grecu, Dan, additional, Mouterde, Gaël, additional, Govoni, Marcello, additional, Punzi, Leonardo, additional, Damjanov, Nemanja S, additional, Keen, Helen Isobel, additional, Bruyn, George AW, additional, Terslev, Lene, additional, D'Agostino, Maria-Antonietta, additional, Scirè, Carlo Alberto, additional, and Iagnocco, Annamaria, additional

Published
2020
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99. Association of Silicone Breast Implants, Breast Cancer and Anti-RNA Polymerase III Autoantibodies in Systemic Sclerosis: Case-Based Review

Author

De Angelis,Rossella, Di Battista,Jacopo, Smerilli,Gianluca, Cipolletta,Edoardo, Di Carlo,Marco, Salaffi,Fausto, De Angelis,Rossella, Di Battista,Jacopo, Smerilli,Gianluca, Cipolletta,Edoardo, Di Carlo,Marco, and Salaffi,Fausto

Abstract

Rossella De Angelis, Jacopo Di Battista, Gianluca Smerilli, Edoardo Cipolletta, Marco Di Carlo, Fausto Salaffi Rheumatology Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Jesi, Ancona, ItalyCorrespondence: Rossella De AngelisRheumatology Clinic, “Carlo Urbani” Hospital, Jesi, Ancona 60035, ItalyEmail r.deangelis@staff.univpm.itAbstract: Some case reports and small case series of patients with silicone breast implant (SBI) have reported the development of systemic sclerosis (SSc) many years later, despite conflicting evidence of this association in the literature. Recently, patients with SSc and anti-RNA polymerase III antibodies positivity have been associated with previous silicone implants and/or breast cancer, showing clinical features that differ from the classic SSc, such as rapid and diffuse cutaneous involvement and scleroderma renal crisis (SRC). The specific autoimmune reaction is not yet fully understood, although knowledge in this regard is increasing. We describe a case that can support these previous observations, strengthening this association which must be taken into account. Clinicians should be aware of this new clinical entity, given the widespread use of silicone implants.Keywords: systemic sclerosis, silicone breast implant, anti-RNA polymerase III antibodies, cancer

Published
2020

100. Sonographic assessment of cartilage damage at the metacarpal head in rheumatoid arthritis: qualitative versus quantitative methods.

Author

Cipolletta, Edoardo, Mandl, Peter, Matteo, Andrea Di, Mirza, Riccardo Mashadi, Passarini, Giancarlo, Grassi, Walter, and Filippucci, Emilio

Subjects
*CARTILAGE, *METACARPOPHALANGEAL joint, *METACARPUS, *QUANTITATIVE research, *HEALTH outcome assessment, *QUALITATIVE research, *RHEUMATOID arthritis, *DESCRIPTIVE statistics, *DATA analysis software, *STATISTICAL correlation
Abstract

Objective To test the validity of the OMERACT semi-quantitative score by comparing with a quantitative method in the US assessment of hyaline cartilage at the metacarpal head (MH) in patients with RA and healthy controls (HCs). Methods The hyaline cartilage from the second to fifth MHs of both hands was scanned. Hyaline cartilage was scored semi-quantitatively and quantitatively by measuring cartilage thickness and comparing with reference values. In RA patients, radiographic joint space narrowing (JSN) was scored on the same joints using the Simple Erosion Narrowing Score (SENS). Results A total of 408 MHs in 51 RA patients and 320 MHs in 40 HSs were evaluated. The OMERACT semi-quantitative score was quicker to perform than the quantitative method [6.0 min (s. d. 0.5) vs 8.0 (1.5); P  < 0.01]. A significant correlation between the US scores (R  = 0.68) and between the US scores and the JSN-SENS (R  = 0.61 and R  = 0.63 for the semi-quantitative and quantitative method, respectively) was found. The frequency of cartilage abnormalities was similar between the two US methods in RA patients (58.8% and 51.0% of RA patients for the semi-quantitative and quantitative method, respectively; P  = 0.46), while the former revealed more abnormalities in HCs (27.5% and 7.5% of HCs; P  = 0.02). Conclusion The higher feasibility of the OMERACT semi-quantitative score suggests its use as a first-choice method in the evaluation of cartilage damage. However, despite its limits, the quantitative assessment of HCs, providing patient-tailored information with age- and sex-corrected cut-off values, may represent a valid supplement for optimizing the evaluation of cartilage damage in selected cases. [ABSTRACT FROM AUTHOR]

Published
2022
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