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Humanized Biomimetic Nanovesicles In article number 2101437, Assaf Zinger, Francesca Taraballi, Robert Krencik, and co‐workers optimize and validate the scalable production of neuron‐targeting biomimetic nanovesicles (NV) with distinct lipid backbones suited to potential therapeutic cargo by integrating membrane proteins from human pluripotent stem cell‐derived neurons. NVs with neuronderived membrane proteins exhibit enhanced neuronal association and uptake compared to bare NVs. These customizable NVs enable next‐generation functionalized theranostics for neurodegeneration. [Image: see text]

Lithium‐Ion Batteries In article number 2101646, Jianhui Wang, Atsuo Yamada and co‐workers report salt‐concentrated electrolytes can overcome various challenges for lithium‐ion full cells that operate in a wide temperature range from ‐20 to 100 °C. This achievement contributes to building a novel power battery pack that requires no thermal management system and deliveries greatly enhanced systematic energy densities in both gravimetry and volumetry. [Image: see text]

Regulating Cardiomyocyte Differentiation In article number 2100849, Wuming Wang, Gang Lu, Wai‐Yee Chan, and co‐workers demonstrate the role of Pten in regulating cardiomyocyte differentiation by modulating non‐CG DNA methylation via Dnmt3. The cover shows the gene transcription process which resembles the train running on the railway and implies that the regulation mechanism of many biological processes remains unknown like the outer space. The study reveals that cardiac genes are regulated by non‐CG DNA methylation during cardiomyocyte differentiation. [Image: see text]

Boron Nitride Nanostripes In article number 2101455, Khadiza Ali, J. Enrique Ortega, Frederik Schiller, and co‐workers explore a novel approach to nanopatterning a material with practical technological impact, namely growing hexagonal boron nitride (hBN) mono‐layers on vicinal surfaces. hBN forms a continuous atomically‐thin carpet on a curved rhodium (Rh) crystal, revealing a transformation from 2D to 1D electronic band structure at the Rh(337) orientation through electron scattering at N‐step‐Rh interface bonding points. [Image: see text]

Nanomembrane Electronics In article number 2101037 by Woon‐Hong Yeo, Hyojung J. Choo, and co‐workers, a wireless, non‐invasive nanomembrane system is reported that integrates wearable printed electronics for real‐time, continuous monitoring of volumetric muscle loss (VML) on craniofacial muscles. The craniofacial VML model, using biopsy punch‐induced masseter muscle injury, shows impaired muscle regeneration. [Image: see text]

Bioinspired Biomaterials A silk cocoon is nestled within a mussel shell. Taking inspiration from the adhesive property of mussels and the assembly properties of silk materials new, water‐based, eco‐friendly glues with exceptional underwater adhesion performance can be formulated. More details can be found in article number 2004786 by Gianluca M. Farinola, Fiorenzo G. Omenetto, and co‐workers. [Image: see text]

In article number 2004319, Wantao Chen, Xu Wang and co‐workers report the restoration of H3k27me3 modification epigenetically silences circadian gene Cry1 expression and sensitizes leptin signaling to reduce obesity‐related properties. It implicates Kdm6a as an attractive drug target for obesity and metabolic disorders. [Image: see text]

In article number 2004872, Huanjun Chen, Shaozhi Deng, and co‐workers realize a nanoscale tailoring of mid‐infrared electromagnetic field localizations in van der Waals α‐MoO(3) microstructures of different shapes and sizes. This is enabled by the synergy of in‐plane hyperbolic phonon polaritons and spatial confinement effects. Furthermore, the authors show that orientation of the in‐plane isofrequency curve relative to the microstructure edge is a critical parameter governing the localized electromagnetic field distributions. [Image: see text]

In article number 2100532, Sri Ramulu Torati, CheolGi Kim, and co‐workers develop the magnetophoretic decoupler for the disaggregation and inter‐particle distance control of magnetic bead cluster for higher efficiency of bio‐carrier role. This magnetophoretic decoupler can split the multiple bead pairs in different directions using single driving force, and linearly control the inter‐particle distance between them through the angle of the external field. [Image: see text]

In article number 2004627, Xiao Lin, Yuxuan Mao, Lei Yang and co‐workers report an innovative multi‐functional ionic skin (MiS) with broad‐spectrum anti‐microbial activity and multi‐modal sensing capability for smart and expedited wound care. MiS demonstrates a revolutionary wound management solution that promotes wound healing, realizes real‐time wound diagnosis, and restores multi‐tactile sensing capability of skin, leading to a paradigm shift from conventional dressing to a smart and comprehensive wound management. [Image: see text]

In article number 2003535, Rongrong Zhu and co‐workers report the role of MgFe‐LDH nanoparticles as a promising LIF replacement in maintaining mESCs self‐renewal and pluripotency. Combined transcriptomic and proteomic analysis reveals that MgFe‐LDH could activate LIFR regulating signaling pathways, while the extra Fe(2+) provided by MgFe‐LDH also enhances TET1/2 abundance related to DNA demethylation. This biocompatible MgFe‐LDH nanoparticle favors economical and efficient replacement for LIF in large‐scale expansion of ESCs. [Image: see text]

In article number 2004689, Jinyun Liu, Huigang Zhang, and co‐workers present a self‐healing flexible quasi‐solid Zn‐ion battery composing of flexible all‐in‐one cathode and anode, and a self‐healing hydrogel electrolyte. After cutting/healing, and bending at different angles, the battery keeps stable electric properties, indicating a potential for application in self‐healing and wearable electronics. [Image: see text]

The COVID‐19 pandemic has pointed out the urgent need to employ advanced and smart materials to realize innovative medical protective equipment. To this end, the next‐generation face masks are conceived to be personalized, smart, and reusable. This great achievement can be accomplished thanks to light‐responsive and fibrous nanomaterials' unique chemical and physical properties. This synergistic approach allows the realization of a new generation of face masks effective against pathogens upon light activation. For further information see the Concept article by F. Pierini et al. on page 6112.

The strain‐multiplexing capability of flexible‐template reconfigurable diffractive metalenses (FDMLs) holds assurance for advancing technologies for artificial intelligence sensors and actuators. These miniature metalens sensors could provide access to tunable bandwidth and focusing to accurately map external strain or forces. The large‐scale surface relief metalenses, fabricated by Rajib Ahmed and Haider Butt in article number 2003394, consist of metal‐coated hemispherical cavities in a hexagonal closepacked arrangement to enhance tunable focal length, numerical aperture, and fill factor, FF ~100%. [Image: see text]

In article number 2001955, André R. Studart, Andres F. Arrieta, and co‐workers demonstrate a family of mechanical metamaterials exploiting sheets patterned with locally bistable domes. The metamaterial's strong hierarchical response enables tunable mechanical properties and programmed geometry adaptation. The strain energy stored by local dome inversion simplifies soft robotics grippers' actuation and enables memory and computation of spatially‐distributed mechanical signals in thin skins. [Image: see text]

In article number 2001148, Moonsang Lee, Jeong Young Park, and co‐workers demonstrate that fast‐disappearing hot holes are directly visualized using photoconductive atomic force microscopy. Experimental and numerical analysis show that hot spots at the edge of plasmonic nanostructures of Au nanoprisms on p‐type GaN exhibit enhanced hot hole flux driven by surface plasmons. [Image: see text]

Little is known about how glycogen metabolism is manipulated during exercise. In article number 2001502, John Zhong Li, Tiemin Liu, Xingxing Kong, and coworkers identify that interferon regulatory factor 4 (IRF4) in skeletal muscle regulates glycogen metabolism and subsequent exercise capacity. This work reveals a regulatory pathway including IRF4/protein targeting to glycogen (PTG)/glycogen synthesis on controlling exercise capacity. [Image: see text]

In article number 2000843, Mariana Medina‐Sánchez and co‐workers demonstrate a spiralshaped micropropeller that can capture, transport, and release a zygote, actuated solely by an external rotating magnetic fi eld, as a noninvasive alternative concept to laparoscopy, that is, zygote intrafallopian transfer by micromotors. This procedure is envisioned to improve the embryo implantation rates, which nowadays is one of the main causes of miscarriage in assisted fertilization. [Image: see text]

In article number 2000098, Bo Liu, Chuanpeng Liu, Yongjun Dang, Cheng Luo, and co‐workers describe the fi rst covalent and allosteric inhibitors targeting RhoA, which had been deemed as an “undruggable” protein target. This study reveals a novel allosteric regulatory site within the Rho family, which could be exploited for anti‐metastasis drug development, and also provides a novel strategy for inhibitor discovery toward “undruggable” proteins. [Image: see text]

Present challenges in electrochromic devices include the limited transmissive and reflective inter‐switchability, while achieving high optical contrast, fast switching speed, and cycling stability, simultaneously. In article number 1903198, Pooi See Lee and co‐workers develop a quasi‐solid‐state tristate reversible electrochemical mirror device, which offers highly reversible switching between transparent, greyish‐blue, and mirror (reflective) optical states. The alloying approach facilitates the electrodeposition and dissolution of Cu mirror film, allowing enhanced device stability. [Image: see text]

In article number 1903642, Jan C. M. van Hest, Fei Peng, Yingfeng Tu, and co‐workers design an intelligent biomimetic nanocarrier, based on the crosslinking reaction of hyaluronic acid with the ancillary anticarcinogen cisplatin in the presence of doxorubicin‐decorated gold nanorods followed by cloaking of the cancer cell membrane. Upon NIR laser irradiation, in situ photothermal therapy is conducted which further induces hyperthermiatriggered on‐demand drug release from the nanogel reservoir to achieve a synergistic photothermal/chemo‐therapy. Cover image designed by Junbin Gao. [Image: see text]

Electrochemical Computing System In article number 2104076, Megumi Akai‐Kasaya and co‐workers develop a simple computing system based on the ionic current of electrochemical solutions at micro‐scale electrodes. In this system, even deionized water can show great computational power in solving higher‐order nonlinear problems. The addition of polyoxometalate molecules diversifies the Faradic currents, which makes it better at predicting periodic signals. [Image: see text]

Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co‐workers, osteocyte neuropeptide Y (NPY)‐dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ‐Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone‐fat imbalance induced by aging and estrogen deficiency. [Image: see text]

Cancer Cells In article number 2101029 by Yihai Cao and co‐workers, it is shown that interleukin‐33 (IL‐33)‐activated macrophages protect melanoma cells from tumor‐infiltrating lymphocytemediated killing. This cover shows a new mechanism of immune T cell‐mediated cancer killing. In the tumor environment, macrophages produce proteases to affect the T cell and cancer cell interaction. The monkey king represents immune T cell, and the bull demon represents cancer cell. [Image: see text]

Epigenome‐Wide Association Study In article number 2100727 by Yongshuai Jiang, and co‐workers, the research process of Epigenome‐wide association study (EWAS), its application in biology and clinical translation are discussed. It concludes by analyzing the current limitations and forecasting the future of EWAS. A decade has passed since EWAS was applied to analyze complex diseases. The cover is full of blessings for the 10th anniversary of EWAS and expresses the dedication of researchers. [Image: see text]

Neuron‐Inspired Steiner Tree Networks In article number 2100141 by Min Gu and co‐workers, neuron‐inspired Steiner tree networks are proposed and studied as a new method to create low‐density metamaterials, where novel mechanical properties and photonic topological quasiparticles can be discovered. The Steiner tree networks not only demonstrate a twist‐induced mechanical property enhancement, but also host an exotic photonic Fermion resulting from accidental degeneracy. [Image: see text]

Spatial Micro‐Water Manipulation An octopus with homogeneously soft structure can easily hide in rocks, where an athlete can throw javelin in precisely controlled manner thanks to the articular structure. Nature designed these distinctive structures by adjusting the amount of water inside. For taking both of their kinematics, the spatial micro‐water molecule manipulation maneuvers the amount of water in the hydrogel enabling the alteration between two structures. More details can be found in article number 2102536 by Seung Hwan Ko and co‐workers. [Image: see text]