51. Abnormal cortical brain integration of somatosensory afferents in ALS
- Author
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Sina Sangari, Guillaume Marrelec, Véronique Marchand-Pauvert, Alain Giron, Pierre-François Pradat, Laboratoire d'Imagerie Biomédicale (LIB), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL-UPMC, Gestionnaire, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Adult ,Male ,0301 basic medicine ,Sensory system ,Wrist ,Somatosensory system ,03 medical and health sciences ,0302 clinical medicine ,Evoked Potentials, Somatosensory ,Physiology (medical) ,medicine ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Amyotrophic lateral sclerosis ,Ulnar Nerve ,Depression (differential diagnoses) ,Aged ,Afferent Pathways ,business.industry ,Amyotrophic Lateral Sclerosis ,Somatosensory Cortex ,Middle Aged ,medicine.disease ,Electric Stimulation ,Sensory Systems ,Median Nerve ,Peripheral ,body regions ,030104 developmental biology ,medicine.anatomical_structure ,Neurology ,Somatosensory evoked potential ,Scalp ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Objectives Infraclinical sensory alterations have been reported at early stages of amyotrophic lateral sclerosis (ALS). While previous studies mainly focused on early somatosensory evoked potentials (SEPs), late SEPs, which reflect on cortical pathways involved in cognitive-motor functions, are relatively underinvestigated. Early and late SEPs were compared to assess their alterations in ALS. Methods Median and ulnar nerves were electrically stimulated at the wrist, at 9 times the perceptual threshold, in 21 ALS patients without clinical evidence of sensory deficits, and 21 age- and gender-matched controls. SEPs were recorded at the Erb point using surface electrodes and using a needle inserted in the scalp, in front of the primary somatosensory area (with reference electrode on the ear lobe). Results Compared to controls, ALS patients showed comparable peripheral (N9) and early cortical component (N20, P25, N30) reductions, while the late cortical components (N60, P100) were more depressed than the early ones. Conclusions The peripheral sensory alteration likely contributed to late SEP depression to a lesser extent than that of early SEPs. Significance Late SEPs may provide new insights on abnormal cortical excitability affecting brain areas involved in cognitive-motor functions.
- Published
- 2018
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