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62. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Author

Butler, Christopher C, primary, Hobbs, F D Richard, additional, Gbinigie, Oghenekome A, additional, Rahman, Najib M, additional, Hayward, Gail, additional, Richards, Duncan B, additional, Dorward, Jienchi, additional, Lowe, David M, additional, Standing, Joseph F, additional, Breuer, Judith, additional, Khoo, Saye, additional, Petrou, Stavros, additional, Hood, Kerenza, additional, Nguyen-Van-Tam, Jonathan S, additional, Patel, Mahendra G, additional, Saville, Benjamin R, additional, Marion, Joe, additional, Ogburn, Emma, additional, Allen, Julie, additional, Rutter, Heather, additional, Francis, Nick, additional, Thomas, Nicholas P B, additional, Evans, Philip, additional, Dobson, Melissa, additional, Madden, Tracie-Ann, additional, Holmes, Jane, additional, Harris, Victoria, additional, Png, May Ee, additional, Lown, Mark, additional, van Hecke, Oliver, additional, Detry, Michelle A, additional, Saunders, Christina T, additional, Fitzgerald, Mark, additional, Berry, Nicholas S, additional, Mwandigha, Lazaro, additional, Galal, Ushma, additional, Mort, Sam, additional, Jani, Bhautesh D, additional, Hart, Nigel D, additional, Ahmed, Haroon, additional, Butler, Daniel, additional, McKenna, Micheal, additional, Chalk, Jem, additional, Lavallee, Layla, additional, Hadley, Elizabeth, additional, Cureton, Lucy, additional, Benysek, Magdalena, additional, Andersson, Monique, additional, Coates, Maria, additional, Barrett, Sarah, additional, Bateman, Clare, additional, Davies, Jennifer C, additional, Raymundo-Wood, Ivy, additional, Ustianowski, Andrew, additional, Carson-Stevens, Andrew, additional, Yu, Ly-Mee, additional, Little, Paul, additional, Agyeman, Akosua A, additional, Ahmed, Tanveer, additional, Allcock, Damien, additional, Beltran-Martinez, Adrian, additional, Benedict, Oluseye E, additional, Bird, Nigel, additional, Brennan, Laura, additional, Brown, Julianne, additional, Burns, Gerard, additional, Butler, Mike, additional, Cheng, Zelda, additional, Danson, Ruth, additional, de Kare-Silver, Nigel, additional, Dhasmana, Devesh, additional, Dickson, Jon, additional, Engamba, Serge, additional, Fisher, Stacey, additional, Fox, Robin, additional, Frost, Eve, additional, Gaunt, Richard, additional, Ghosh, Sarit, additional, Gilkar, Ishtiaq, additional, Goodman, Anna, additional, Granier, Steve, additional, Howell, Aleksandra, additional, Hussain, Iqbal, additional, Hutchinson, Simon, additional, Imlach, Marie, additional, Irving, Greg, additional, Jacobsen, Nicholas, additional, Kennard, James, additional, Khan, Umar, additional, Knox, Kyle, additional, Krasucki, Christopher, additional, Law, Tom, additional, Lee, Rem, additional, Lester, Nicola, additional, Lewis, David, additional, Lunn, James, additional, Mackintosh, Claire I., additional, Mathukia, Mehul, additional, Moore, Patrick, additional, Morton, Seb, additional, Murphy, Daniel, additional, Nally, Rhiannon, additional, Ndukauba, Chinonso, additional, Ogundapo, Olufunto, additional, Okeke, Henry, additional, Patel, Amit, additional, Patel, Kavil, additional, Penfold, Ruth, additional, Poonian, Satveer, additional, Popoola, Olajide, additional, Pora, Alexander, additional, Prasad, Vibhore, additional, Prasad, Rishabh, additional, Razzaq, Omair, additional, Richardson, Scot, additional, Royal, Simon, additional, Safa, Afsana, additional, Sehdev, Satash, additional, Sevenoaks, Tamsin, additional, Shah, Divya, additional, Sheikh, Aadil, additional, Short, Vanessa, additional, Sidhu, Baljinder S, additional, Singh, Ivor, additional, Soni, Yusuf, additional, Thalasselis, Chris, additional, Wilson, Pete, additional, Wingfield, David, additional, Wong, Michael, additional, Woodall, Maximillian N J, additional, Wooding, Nick, additional, Woods, Sharon, additional, Yong, Joanna, additional, Yongblah, Francis, additional, and Zafar, Azhar, additional

Published
2023
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63. sj-docx-6-bmi-10.1177_11772719221144459 – Supplemental material for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection?

Author

Edwards, George, Seeley, Anna, Carter, Adam, Patrick Smith, Maia, Cross, Elizabeth LA, Hughes, Kathryn, Van den Bruel, Ann, Llewelyn, Martin J, Verbakel, Jan Y, and Hayward, Gail

Subjects
Biochemistry
Abstract

Supplemental material, sj-docx-6-bmi-10.1177_11772719221144459 for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection? by George Edwards, Anna Seeley, Adam Carter, Maia Patrick Smith, Elizabeth LA Cross, Kathryn Hughes, Ann Van den Bruel, Martin J Llewelyn, Jan Y Verbakel and Gail Hayward in Biomarker Insights

Published
2023
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64. sj-docx-4-bmi-10.1177_11772719221144459 – Supplemental material for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection?

Author

Edwards, George, Seeley, Anna, Carter, Adam, Patrick Smith, Maia, Cross, Elizabeth LA, Hughes, Kathryn, Van den Bruel, Ann, Llewelyn, Martin J, Verbakel, Jan Y, and Hayward, Gail

Subjects
Biochemistry
Abstract

Supplemental material, sj-docx-4-bmi-10.1177_11772719221144459 for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection? by George Edwards, Anna Seeley, Adam Carter, Maia Patrick Smith, Elizabeth LA Cross, Kathryn Hughes, Ann Van den Bruel, Martin J Llewelyn, Jan Y Verbakel and Gail Hayward in Biomarker Insights

Published
2023
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65. sj-docx-1-bmi-10.1177_11772719221144459 – Supplemental material for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection?

Author

Edwards, George, Seeley, Anna, Carter, Adam, Patrick Smith, Maia, Cross, Elizabeth LA, Hughes, Kathryn, Van den Bruel, Ann, Llewelyn, Martin J, Verbakel, Jan Y, and Hayward, Gail

Subjects
Biochemistry
Abstract

Supplemental material, sj-docx-1-bmi-10.1177_11772719221144459 for What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection? by George Edwards, Anna Seeley, Adam Carter, Maia Patrick Smith, Elizabeth LA Cross, Kathryn Hughes, Ann Van den Bruel, Martin J Llewelyn, Jan Y Verbakel and Gail Hayward in Biomarker Insights

Published
2023
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67. Evaluation of the diagnostic accuracy of two point-of-care tests for COVID-19 when used in symptomatic patients in community settings in the UK primary care COVID diagnostic accuracy platform trial (RAPTOR-C19).

Author

Nicholson, Brian D., Turner, Philip J., Fanshawe, Thomas R., Williams, Alice J., Amirthalingam, Gayatri, Tonner, Sharon, Zambon, Maria, Body, Richard, Davies, Kerrie, Perera, Rafael, de Lusignan, Simon, Hayward, Gail N., and Hobbs, F.D. Richard

Subjects
COVID-19 treatment, POINT-of-care testing, COVID-19 testing, MEDICAL personnel, ANTIGEN analysis
Abstract

Background and objective: Point-of-care lateral flow device antigen testing has been used extensively to identify individuals with active SARS-CoV-2 infection in the community. This study aimed to evaluate the diagnostic accuracy of two point-of-care tests (POCTs) for SARS-CoV-2 in routine community care. Methods: Adults and children with symptoms consistent with suspected current COVID-19 infection were prospectively recruited from 19 UK general practices and two COVID-19 testing centres between October 2020 and October 2021. Participants were tested by trained healthcare workers using at least one of two index POCTs (Roche-branded SD Biosensor Standard™ Q SARS-CoV-2 Rapid Antigen Test and/or BD Veritor™ System for Rapid Detection of SARS-CoV-2). The reference standard was laboratory triplex reverse transcription quantitative PCR (RT-PCR) using a combined nasal/oropharyngeal swab. Diagnostic accuracy parameters were estimated, with 95% confidence intervals (CIs), overall, in relation to RT-PCR cycle threshold and in pre-specified subgroups. Results: Of 663 participants included in the primary analysis, 39.2% (260/663, 95% CI 35.5% to 43.0%) had a positive RT-PCR result. The SD Biosensor POCT had sensitivity 84.0% (178/212, 78.3% to 88.6%) and specificity 98.5% (328/333, 96.5% to 99.5%), and the BD Veritor POCT had sensitivity 76.5% (127/166, 69.3% to 82.7%) and specificity 98.8% (249/252, 96.6% to 99.8%) compared with RT-PCR. Sensitivity of both devices dropped substantially at cycle thresholds ≥30 and in participants more than 7 days after onset of symptoms. Conclusions: Both POCTs assessed exceed the Medicines and Healthcare products Regulatory Agency target product profile's minimum acceptable specificity of 95%. Confidence intervals for both tests include the minimum acceptable sensitivity of 80%. In symptomatic patients, negative results on these two POCTs do not preclude the possibility of infection. Tests should not be expected to reliably detect disease more than a week after symptom onset, when viral load may be reduced. Registration: ISRCTN142269. [ABSTRACT FROM AUTHOR]

Published
2023
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69. Self-sampling to identify pathogens and inflammatory markers in patients with acute sore throat: Feasibility study

Author

Lown, Mark, primary, Miles, Elizabeth A., additional, Fisk, Helena L., additional, Smith, Kirsten A., additional, Muller, Ingrid, additional, Maund, Emma, additional, Rogers, Kirsty, additional, Becque, Taeko, additional, Hayward, Gail, additional, Moore, Michael, additional, Little, Paul, additional, Glogowska, Margaret, additional, Hay, Alastair D., additional, Stuart, Beth, additional, Mantzourani, Efi, additional, Butler, Chris, additional, Bostock, Jennifer, additional, Davies, Firoza, additional, Dickerson, Ian, additional, Thompson, Natalie, additional, and Francis, Nick, additional

Published
2022
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72. A Diagnostic Accuracy Study to Evaluate Standard Rapid Diagnostic Test (RDT) Alone to Safely Rule Out Imported Malaria in Children Presenting to UK Emergency Departments.

Author

Bird, Chris, Hayward, Gail N, Turner, Philip J, Merrick, Vanessa, Lyttle, Mark D, Mullen, Niall, Fanshawe, Thomas R, and (PERUKI), for the Paediatric Emergency Research in the UK and Ireland

Subjects
*MALARIA diagnosis, *RESEARCH, *HOSPITAL emergency services, *PREDICTIVE tests, *HEMOGLOBINS, *CONFIDENCE intervals, *MICROSCOPY, *MULTIPLE regression analysis, *RAPID diagnostic tests, *RETROSPECTIVE studies, *BLOOD collection, *DESCRIPTIVE statistics, *DISEASE prevalence, *PLATELET count, *RESEARCH funding, *SENSITIVITY & specificity (Statistics), *POLYMERASE chain reaction, *DATA analysis software, *DIAGNOSTIC errors, *ANTIGENS, *CHILDREN
Abstract

Background Microscopy is the gold standard for malaria diagnosis but is dependent on trained personnel. Rapid diagnostic tests (RDTs) form the mainstay of diagnosis in endemic areas without access to high-quality microscopy. We aimed to evaluate whether RDT alone could rule out imported malaria in children presenting to UK emergency departments (EDs). Methods UK-based, multi-center, retrospective, diagnostic accuracy study. Included : any child <16 years presenting to ED with history of fever and travel to a malaria-endemic country, between 01/01/2016 and 31/12/2017. Diagnosis: microscopy for malarial parasites (clinical reference standard) and RDT (index test). UK Health Research Authority approval: 20/HRA/1341. Results There were 47 cases of malaria out of 1,414 eligible cases (prevalence 3.3%) in a cohort of children whose median age was 4 years (IQR 2–9), of whom 43% were female. Cases of Plasmodium falciparum totaled 36 (77%, prevalence 2.5%). The sensitivity of RDT alone to detect malaria infection due to any Plasmodium species was 93.6% (95% CI 82.5–98.7%), specificity 99.4% (95% CI 98.9–99.7%), positive predictive value 84.6% (95% CI 71.9–93.1%) and negative predictive value 99.8% (95% CI 99.4–100.0%). Sensitivity of RDT to detect P. falciparum infection was 100% (90.3–100%), specificity 98.8% (98.1–99.3%), positive predictive value 69.2% (54.9–81.2%, n = 46/52) and negative predictive value 100% (99.7–100%, n = 1,362/1,362). Conclusions RDTs were 100% sensitive in detecting P. falciparum malaria. However, lower sensitivity for other malaria species and the rise of pfhrp2 and pfhrp3 (pfhrp2/3) gene deletions in the P. falciparum parasite mandate the continued use of microscopy for diagnosing malaria. [ABSTRACT FROM AUTHOR]

Published
2023
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74. A prospective diagnostic evaluation of accuracy of self-taken and healthcare worker-taken swabs for rapid COVID-19 testing

Author

Savage, Helen, Finch, Lorna, Body, Richard, Watkins, Rachel, Hayward, Gail, Cook, Eloïse, CubasAtienzar, Ana, Cuevas, Luis, MacPherson, Peter, and Adams, Emily

Subjects
qy_4, wc_506, wa_20_5
Abstract

Background\ud \ud Rapid diagnostic tests (RDTs) developed for point of care detection of SARS-CoV-2 antigen are recommended by WHO to use trained health care workers to collect samples. We hypothesised that self-taken samples are non-inferior for use with RDTs to diagnose COVID-19. We designed a prospective diagnostic evaluation comparing self-taken and healthcare worker (HCW)-taken throat/nasal swabs to perform RDTs for SARS-CoV-2, and how these compare to RT-PCR.\ud \ud Methods\ud \ud Eligible participants 18 years or older with symptoms of COVID-19. 250 participants recruited at the NHS Test and Trace drive-through community PCR testing site (Liverpool, UK); one withdrew before analysis. Self-administered throat/nasal swab for the Covios® RDT, a trained HCW taken throat/nasal sample for PCR and HCW comparison throat/nasal swab for RDT were collected. RDT results were compared to RT-PCR, as the reference standard, to calculate sensitivity and specificity.\ud \ud Findings\ud \ud Seventy-five participants (75/249, 30.1%) were positive by RT-PCR. RDTs with self-taken swabs had a sensitivity of 90.5% (67/74, 95% CI: 83.9–97.2), compared to 78.4% (58/74, 95% CI: 69.0–87.8) for HCW-taken swabs (absolute difference 12.2%, 95% CI: 4.7–19.6, p = 0.003). Specificity for self-taken swabs was 99.4% (173/174, 95% CI: 98.3–100.0), versus 98.9% (172/174, 95% CI: 97.3–100.0) for HCW-taken swabs (absolute difference 0.6%, 95% CI: 0.5–1.7, p = 0.317). The PPV of self-taken RDTs (98.5%, 67/68, 95% CI: 95.7–100.0) and HCW-taken RDTs (96.7%, 58/60, 95% CI 92.1–100.0) were not significantly different (p = 0.262). However, the NPV of self-taken swab RDTs was significantly higher (96.1%, 173/180, 95% CI: 93.2–98.9) than HCW-taken RDTs (91.5%, 172/188, 95% CI 87.5–95.5, p = 0.003).\ud \ud Interpretation\ud \ud In conclusion, self-taken swabs for COVID-19 testing offer an accurate alternative to healthcare worker taken swabs for use with RDTs. Our results demonstrate that, with no training, self-taken throat/nasal samples can be used by lay individuals as part of rapid testing programmes for symptomatic adults. This is especially important where the lack of trained healthcare workers restricts access to testing.

Published
2022

76. Internet Tool to Support Self-Assessment and Self-Swabbing of Sore Throat: Development and Feasibility Study (Preprint)

Author

Lown, Mark, primary, Smith, Kirsten A, additional, Muller, Ingrid, additional, Woods, Catherine, additional, Maund, Emma, additional, Rogers, Kirsty, additional, Becque, Taeko, additional, Hayward, Gail, additional, Moore, Michael, additional, Little, Paul, additional, Glogowska, Margaret, additional, Hay, Alastair, additional, Stuart, Beth, additional, Mantzourani, Efi, additional, Wilcox, Christopher R, additional, Thompson, Natalie, additional, and Francis, Nick A, additional

Published
2022
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77. Diagnostic performance of GENEDIA W and ActiveXpress+ COVID-19 antigens tests among symptomatic individuals in Peru and The United Kingdom

Author

Palomino-Padilla, Sandra, Finch, Lorna, de Vos, Margaretha, Savage, Helen Rose, Villa-Castillo, Luz, Hayward, Gail, Cook, Eloïse, Escadafal, Camille, Body, Richard, Adams, Emily R., Ugarte-Gil, Cesar, and Cubas Atienzar, Ana Isabel

Subjects
COVID-19 Testing, Multidisciplinary, Peru, Humans, Prospective Studies, COVID-19, SARS-CoV-2, United Kingdom
Abstract

Objectives In order to generate independent performance data regarding accuracy of COVID-19 antigen-based rapid diagnostic tests (Ag-RDTs), prospective diagnostic evaluation studies across multiple sites are required to evaluate their performance in different clinical settings. This report describes the clinical evaluation the GENEDIA W COVID-19 Ag Device (Green Cross Medical Science Corp., Chungbuk, Korea) and the ActiveXpress+ COVID-19 Complete Testing Kit (Edinburgh Genetics Ltd, UK), in two testing sites Peru and the United Kingdom. Methods Nasopharyngeal swabs collected from 456 symptomatic patients at primary points of care in Lima, Peru and 610 symptomatic participants at a COVID-19 Drive-Through testing site in Liverpool, England were analyzed by Ag-RDT and compared to RT-PCR. Analytical evaluation of both Ag-RDTs was assessed using serial dilutions of direct culture supernatant of a clinical SARS-CoV-2 isolate from the B.1.1.7 lineage. Results For GENEDIA brand, the values of overall sensitivity and specificity were 60.4% [95% CI 52.4–67.9%], and 99.2% [95% CI 97.6–99.7%] respectively; and for Active Xpress+ the overall values of sensitivity and specificity were 66.2% [95% CI 54.0–76.5%], and 99.6% [95% CI 97.9–99.9%] respectively. The analytical limit of detection was determined at 5.0 x 102 pfu/ml what equals to approximately 1.0 x 104 gcn/ml for both Ag-RDTs. The UK cohort had lower median Ct values compared to that of Peru during both evaluations. When split by Ct, both Ag-RDTs had optimum sensitivities at Ct Conclusions Whilst the overall clinical sensitivity of the Genedia did not meet WHO minimum performance requirements for rapid immunoassays in either cohort, the ActiveXpress+ did so for the small UK cohort. This study illustrates comparative performance of Ag-RDTs across two global settings and considers the different approaches in evaluation methods.

Published
2023

82. Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial

Author

Dorward, Jienchi, primary, Yu, Ly-Mee, additional, Hayward, Gail, additional, Saville, Benjamin R, additional, Gbinigie, Oghenekome, additional, Van Hecke, Oliver, additional, Ogburn, Emma, additional, Evans, Philip H, additional, Thomas, Nicholas PB, additional, Patel, Mahendra G, additional, Richards, Duncan, additional, Berry, Nicholas, additional, Detry, Michelle A, additional, Saunders, Christina, additional, Fitzgerald, Mark, additional, Harris, Victoria, additional, Shanyinde, Milensu, additional, de Lusignan, Simon, additional, Andersson, Monique I, additional, Butler, Christopher C, additional, and Hobbs, FD Richard, additional

Published
2022
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85. Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial

Author

Butler, Christopher, primary, Hobbs, F.D. Richard, additional, Gbinigie, Oghenekome, additional, Rahman, Najib M., additional, Hayward, Gail, additional, Richards, Duncan, additional, Dorward, Jienchi, additional, Lowe, David, additional, Standing, Joseph F., additional, Breuer, Judith, additional, Khoo, Saye, additional, Petrou, Stavros, additional, Hood, Kerenza, additional, Nguyen-Van-Tam, Jonathan S., additional, Patel, Mahendra, additional, Saville, Benjamin R., additional, Marion, Joe, additional, Ogburn, Emma, additional, Allen, Julie, additional, Rutter, Heather, additional, Francis, Nick, additional, Thomas, Nicholas, additional, Evans, Philip, additional, Dobson, Melissa, additional, Madden, Tracie-Ann, additional, Holmes, Jane, additional, Harris, Victoria, additional, Png, May Ee, additional, Lown, Mark, additional, van Hecke, Oliver, additional, Detry, Michelle, additional, Saunders, Christina, additional, Fitzgerald, Mark, additional, Berry, Nicholas, additional, Mwandigha, Lazaro, additional, Galal, Ushma, additional, Jani, Bhautesh, additional, Hart, Nigel, additional, Butler, Daniel, additional, Chalk, Jeremy, additional, Lavallee, Layla, additional, Hadley, Elizabeth, additional, Cureton, Lucy, additional, Benysek, Magdalena, additional, Andersson, Monique, additional, Coates, Maria, additional, Barrett, Sarah, additional, Bateman, Clare, additional, Davies, Jennifer, additional, Raymundo-Wood, Ivy, additional, Ustianowski, Andrew, additional, Carson-Stevens, Andrew, additional, Yu, Ly-Mee, additional, and Little, Paul, additional

Published
2022
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88. Point of care testing using rapid automated antigen testing for SARS-COV-2 in care homes – an exploratory safety, usability and diagnostic agreement evaluation

Author

Micocci, Massimo, primary, Buckle, Peter, additional, Hayward, Gail, additional, Allen, A Joy, additional, Davies, Kerrie, additional, Kierkegaard, Patrick, additional, Spilsbury, Karen, additional, Thompson, Carl, additional, Astle, Anita, additional, Heath, Ros, additional, Sharpe, Claire, additional, Akrill, Cyd, additional, Lasserson, Dan, additional, Perera, Rafael, additional, Body, Richard, additional, and Gordon, Adam L, additional

Published
2021
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90. Urine collection devices to reduce contamination in urine samples for diagnosis of uncomplicated UTI: a single-blind randomised controlled trial in primary care

Author

Hayward, Gail, primary, Mort, Sam, additional, Yu, Ly-Mee, additional, Voysey, Merryn, additional, Glogowska, Margaret, additional, Croxson, Caroline, additional, Yang, Yaling, additional, Allen, Julie, additional, Cook, Johanna, additional, Tearne, Sarah, additional, Blakey, Nicola, additional, Tonner, Sharon, additional, Sharma, Vanshika, additional, Patil, Meena, additional, Kelly, Sadie, additional, and Butler, Christopher C, additional

Published
2021
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92. Additional file 1 of Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study

Author

Nicholson, Brian D., Hayward, Gail, Turner, Philip J., Lee, Joseph J., Deeks, Alexandra, Logan, Mary, Moore, Abigail, Seeley, Anna, Fanshawe, Thomas, Oke, Jason, Constantinos Koshiaris, Sheppard, James P., Uy Hoang, Vaishnavi Parimalanathan, Edwards, George, Harshana Liyange, Sherlock, Julian, Byford, Rachel, Zambon, Maria, Ellis, Joanna, Bernal, Jamie Lopez, Amirthalingam, Gayatri, Linley, Ezra, Borrow, Ray, Howsam, Gary, Baines, Sophie, Ferreira, Filipa, Lusignan, Simon De, Perera, Rafael, and F. D. Richard Hobbs

Abstract

Additional file 1:. Supplementary Figure S1. Parental Consent Form. Supplementary Figure S2. Participant information sheet for minors (under 6 years). Supplementary Box S1. Baseline data

Published
2021
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93. Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk

Author

Hayward, Gail, primary, Butler, Christopher C, additional, Yu, Ly-Mee, additional, Saville, Benjamin R, additional, Berry, Nicholas, additional, Dorward, Jienchi, additional, Gbinigie, Oghenekome, additional, van Hecke, Oliver, additional, Ogburn, Emma, additional, Swayze, Hannah, additional, Bongard, Emily, additional, Allen, Julie, additional, Tonner, Sharon, additional, Rutter, Heather, additional, Tonkin-Crine, Sarah, additional, Borek, Aleksandra, additional, Judge, David, additional, Grabey, Jenna, additional, de Lusignan, Simon, additional, Thomas, Nicholas P B, additional, Evans, Philip H, additional, Andersson, Monique I, additional, Llewelyn, Martin, additional, Patel, Mahendra, additional, Hopkins, Susan, additional, and Hobbs, F D Richard, additional

Published
2021
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97. Is point-of-care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a point-of-care polymerase chain reaction test for SARS-CoV-2

Author

Micocci, Massimo, primary, Gordon, Adam L, additional, Seo, Mikyung Kelly, additional, Allen, A Joy, additional, Davies, Kerrie, additional, Lasserson, Dan, additional, Thompson, Carl, additional, Spilsbury, Karen, additional, Akrill, Cyd, additional, Heath, Ros, additional, Astle, Anita, additional, Sharpe, Claire, additional, Perera, Rafael, additional, Hayward, Gail, additional, and Buckle, Peter, additional

Published
2021
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100. Examining the effect of evaluation sample size on the sensitivity and specificity of COVID-19 diagnostic tests in practice: a simulation study.

Author

Sammut-Powell, Camilla, Reynard, Charles, Allen, Joy, McDermott, John, Braybrook, Julian, Parisi, Rosa, Lasserson, Daniel, Body, Richard, on behalf of the CONDOR steering committee, Hayward, Gail, Buckle, Peter, Dark, Paul, Davis, Kerrie, Cook, Eloise, Gordon, Adam, Halstead, Anna, Lasserson, Dan, Lewington, Andrew, Nicholson, Brian, and Perera-Salazar, Rafael

Published
2022
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