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52. Galaxy rotation curves disfavor traditional and self-interacting dark matter halos, preferring a disk component or Einasto function

Author

Loizeau, Nicolas and Farrar, Glennys R.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We use the galaxy rotation curves in the SPARC database to compare 9 different dark matter and modified gravity models on an equal footing, paying special attention to the stellar mass-to-light ratios. We compare three non-interacting dark matter models, a self interacting DM (SIDM) model, two hadronically interacting DM (HIDM) models, and three modified Newtonian dynamics type models: MOND, Radial Acceleration Relation (RAR) and a maximal-disk model. The models with DM-gas interactions generate a disky component in the dark matter, which significantly improves the fits to the rotation curves compared to all other models except an Einasto halo; the MOND-type models give significantly worse fits., Comment: We fixed a typo in eq A3, added fig 6 and updated fig 1 and fig 8 with two galaxy subsets of high and low inclinations

Published
2021
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53. Data-driven aggregation in circular deconvolution

Author

Johannes, Jan and Loizeau, Xavier

Subjects
Mathematics - Statistics Theory
Abstract

In a circular deconvolution model we consider the fully data driven density estimation of a circular random variable where the density of the additive independent measurement error is unknown. We have at hand two independent iid samples, one of the contaminated version of the variable of interest, and the other of the additive noise. We show optimality,in an oracle and minimax sense, of a fully data-driven weighted sum of orthogonal series density estimators. Two shapes of random weights are considered, one motivated by a Bayesian approach and the other by a well known model selection method. We derive non-asymptotic upper bounds for the quadratic risk and the maximal quadratic risk over Sobolev-like ellipsoids of the fully data-driven estimator. We compute rates which can be obtained in different configurations for the smoothness of the density of interest and the error density. The rates (strictly) match the optimal oracle or minimax rates for a large variety of cases, and feature otherwise at most a deterioration by a logarithmic factor. We illustrate the performance of the fully data-driven weighted sum of orthogonal series estimators by a simulation study., Comment: 19 pages, 4 figures, 27 appendix pages

Published
2021

54. Mawrth Vallis, Mars: a fascinating place for future in situ exploration

Author

Poulet, François, Gross, Christoph, Horgan, Briony, Loizeau, Damien, Bishop, Janice L., Carter, John, and Orgel, Csilla

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

After the successful landing of the Mars Science Laboratory rover, both NASA and ESA initiated a selection process for potential landing sites for the Mars2020 and ExoMars missions, respectively. Two ellipses located in the Mawrth Vallis region were proposed and evaluated during a series of meetings (3 for Mars2020 mission and 5 for ExoMars). We describe here the regional context of the two proposed ellipses as well as the framework of the objectives of these two missions. Key science targets of the ellipses and their astrobiological interests are reported. This work confirms the proposed ellipses contain multiple past Martian wet environments of subaerial, subsurface and/or subaqueous character, in which to probe the past climate of Mars, build a broad picture of possible past habitable environments, evaluate their exobiological potentials and search for biosignatures in well-preserved rocks. A mission scenario covering several key investigations during the nominal mission of each rover is also presented, as well as descriptions of how the site fulfills the science requirements and expectations of in situ martian exploration. These serve as a basis for potential future exploration of the Mawrth Vallis region with new missions and describe opportunities for human exploration of Mars in terms of resources and science discoveries.

Published
2021
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56. Constraints on Solar System early evolution by MicrOmega analysis of Ryugu carbonates

Author

Loizeau, D., Pilorget, C., Riu, L., Brunetto, R., Bibring, J.-P., Nakato, A., Aléon-Toppani, A., Hatakeda, K., Yogata, K., Carter, J., Le Pivert-Jolivet, T., Yada, T., Okada, T., Usui, T., Langevin, Y., Lantz, C., Baklouti, D., Miyazaki, A., Nishimura, M., Nagashima, K., Kumagai, K., Hitomi, Y., Abe, M., Saiki, T., Tanaka, S., Nakazawa, S., Tsuda, Y., and Watanabe, S.

Published
2023
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57. Low-energy calibration of XENON1T with an internal $$^{{\textbf {37}}}$$ 37 Ar source

Author

E. Aprile, K. Abe, F. Agostini, S. Ahmed Maouloud, M. Alfonsi, L. Althueser, B. Andrieu, E. Angelino, J. R. Angevaare, V. C. Antochi, D. Antón Martin, F. Arneodo, L. Baudis, A. L. Baxter, L. Bellagamba, R. Biondi, A. Bismark, A. Brown, S. Bruenner, G. Bruno, R. Budnik, T. K. Bui, C. Cai, C. Capelli, J. M. R. Cardoso, D. Cichon, A. P. Colijn, J. Conrad, J. J. Cuenca-García, J. P. Cussonneau, V. D’Andrea, M. P. Decowski, P. Di Gangi, S. Di Pede, S. Diglio, K. Eitel, A. Elykov, S. Farrell, A. D. Ferella, C. Ferrari, H. Fischer, W. Fulgione, P. Gaemers, R. Gaior, A. Gallo Rosso, M. Galloway, F. Gao, R. Glade-Beucke, L. Grandi, J. Grigat, M. Guida, R. Hammann, A. Higuera, C. Hils, L. Hoetzsch, J. Howlett, M. Iacovacci, Y. Itow, J. Jakob, F. Joerg, A. Joy, N. Kato, M. Kara, P. Kavrigin, S. Kazama, M. Kobayashi, G. Koltman, A. Kopec, F. Kuger, H. Landsman, R. F. Lang, L. Levinson, I. Li, S. Li, S. Liang, S. Lindemann, M. Lindner, K. Liu, J. Loizeau, F. Lombardi, J. Long, J. A. M. Lopes, Y. Ma, C. Macolino, J. Mahlstedt, A. Mancuso, L. Manenti, F. Marignetti, T. Marrodán Undagoitia, K. Martens, J. Masbou, D. Masson, E. Masson, S. Mastroianni, M. Messina, K. Miuchi, K. Mizukoshi, A. Molinario, S. Moriyama, K. Morå, Y. Mosbacher, M. Murra, J. Müller, K. Ni, U. Oberlack, B. Paetsch, J. Palacio, R. Peres, C. Peters, J. Pienaar, M. Pierre, V. Pizzella, G. Plante, J. Qi, J. Qin, D. Ramírez García, S. Reichard, A. Rocchetti, N. Rupp, L. Sanchez, P. Sanchez-Lucas, J. M. F. dos Santos, I. Sarnoff, G. Sartorelli, J. Schreiner, D. Schulte, P. Schulte, H. Schulze Eißing, M. Schumann, L. Scotto Lavina, M. Selvi, F. Semeria, P. Shagin, S. Shi, E. Shockley, M. Silva, H. Simgen, A. Takeda, P.-L. Tan, A. Terliuk, D. Thers, F. Toschi, G. Trinchero, C. Tunnell, F. Tönnies, K. Valerius, G. Volta, C. Weinheimer, M. Weiss, D. Wenz, C. Wittweg, T. Wolf, D. Xu, Z. Xu, M. Yamashita, L. Yang, J. Ye, L. Yuan, G. Zavattini, S. Zerbo, M. Zhong, T. Zhu, C. Geppert, J. Riemer, and XENON Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A low-energy electronic recoil calibration of XENON1T, a dual-phase xenon time projection chamber, with an internal $${}^{37}$$ 37 Ar source was performed. This calibration source features a 35-day half-life and provides two mono-energetic lines at 2.82 keV and 0.27 keV. The photon yield and electron yield at 2.82 keV are measured to be ( $$32.3\,\pm \,0.3$$ 32.3 ± 0.3 ) photons/keV and ( $$40.6\,\pm \,0.5$$ 40.6 ± 0.5 ) electrons/keV, respectively, in agreement with other measurements and with NEST predictions. The electron yield at 0.27 keV is also measured and it is ( $$68.0^{+6.3}_{-3.7}$$ 68 . 0 - 3.7 + 6.3 ) electrons/keV. The $${}^{37}$$ 37 Ar calibration confirms that the detector is well-understood in the energy region close to the detection threshold, with the 2.82 keV line reconstructed at ( $$2.83\,\pm \,0.02$$ 2.83 ± 0.02 ) keV, which further validates the model used to interpret the low-energy electronic recoil excess previously reported by XENON1T. The ability to efficiently remove argon with cryogenic distillation after the calibration proves that $${}^{37}$$ 37 Ar can be considered as a regular calibration source for multi-tonne xenon detectors.

Published
2023
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59. Detector control system for the CBM-TOF

Author

Dong, S., Huang, G. M., Frühauf, J., Loizeau, P. -A., Deppner, I., Herrmann, N., and Wang, D.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A high-performance time-of-flight (TOF) MRPC wall is being built for the CBM experiment at FAIR for charged hadron identification. The detector control system for the TOF system will be based on EPICS. All components like power supplies for low and high voltages, power distribution boxes, gas control and front-end electronics (FEE) are controlled and monitored. In a test, called mini-CBM, all these functionalities are implemented and tested. For monitoring the detector environment and the status of the front-end electronics, a slow control application is implemented based on IPbus, which is an FPGA-based slow control bus used for the TOF data acquisition system. In addition to the functions of control and monitoring, exception handling and data archiving services are implemented as well. This system has been fully verified in beam tests in 2019 at GSI., Comment: This article is based on my RPC2020 meeting report, see https://agenda.infn.it/event/19942/contributions/108458/

Published
2020
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60. Variations of the surface characteristics of Ryugu returned samples

Author

Aiko Nakato, Toru Yada, Masahiro Nishimura, Kasumi Yogata, Akiko Miyazaki, Kana Nagashima, Kentaro Hatakeda, Kazuya Kumagai, Yuya Hitomi, Hiromichi Soejima, Jean-Pierre Bibring, Cedric Pilorget, Vincent Hamm, Rosario Brunetto, Lucie Riu, Lionel Lourit, Damien Loizeau, Tania Le Pivert-Jolivet, Guillaume Lequertier, Aurelie Moussi-Soffys, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Satoru Nakazawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Sei-ichiro Watanabe, and Yuichi Tsuda

Subjects
Hayabusa2, Ryugu, Curation, Returned samples, Classification, Geography. Anthropology. Recreation, Geodesy, QB275-343, Geology, QE1-996.5
Abstract

Abstract Hayabusa2 spacecraft successfully collected rock samples from the surface of C-type near-Earth asteroid 162173 Ryugu through two touchdowns and brought them back to Earth in 2020. At the Extraterrestrial Sample Curation Center in JAXA, we performed initial description of all samples to obtain fundamental information and prepare the database for sample allocation. We propose morphological classifications for the returned samples based on the initial description of 205 grains described in the first 6 months. The returned samples can be distinguished by four morphological characteristics: dark, glossy, bright, and white. According to coordinated study to provide an initial description and detailed investigation by scanning electron microscopy and X-ray diffraction analysis in this study, these features reflect the differences in the degree of space weathering and mineral assemblages. The degree of space weathering of the four studied grain types is heterogeneous: weak for A0042 (dark group) and C0041 (white group); moderate for C0094 (glossy); and severe for A0017 (bright). The white phase, which is the mineral characteristic of the white group grains, is identified as large carbonate minerals. This is the first effort to classify Ryugu returned samples into distinct categories. Based on these results, researchers can estimate sample characteristics only from the information on the JAXA curation public database. It will be an important reference for sample selection for further investigation. Graphical Abstract

Published
2023
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63. Socioeconomic conditions and children's mental health and quality of life during the COVID-19 pandemic: An intersectional analysis

Author

Amrein, Deborah, Arm-Vernez, Isabelle, Azman, Andrew S., Bal, Antoine, Balavoine, Michael, Barbe, Rémy P., Baysson, Hélène, Berthelot, Julie, Bleich, Patrick, Boehm, Livia, Bouchet, Aminata R., Bryand, Gaëlle, Bucolli, Viola, Collombet, Prune, Cudet, Alain, Davidovic, Vladimir, de Mestral, Carlos, D’Ippolito, Paola, Dubos, Richard, Dumont, Roxane, Eckerle, Isabella, El Merjani, Nacira, Favier, Marion, Francioli, Natalie, Graindorge, Clément, Guessous, Idris, Hagose, Munire, Harnal, Séverine, Hurst, Samia, Kaiser, Laurent, Kherad, Omar, Lamour, Julien, Lescuyer, Pierre, L’Huillier, Arnaud G., Loizeau, Andrea, Lorthe, Elsa, Martinez, Chantal, Mermet, Stéphanie, Nehme, Mayssam, Noël, Natacha, Pennacchio, Francesco, Perez-Saez, Javier, Perrin, Anne, Pittet, Didier, Posfay-Barbe, Klara M., Portier, Jane, Poulain, Géraldine, Pugin, Caroline, Pullen, Nick, Richard, Viviane, Rinaldi, Frederic, Rochat, Deborah, Sahyoun, Cyril, Sakvarelidze, Irine, Samir, Khadija, Santa Ramirez, Hugo Alejandro, Rizzo, Jessica, Schrempft, Stephanie, Semaani, Claire, Stringhini, Silvia, Testini, Stéphanie, Tisserand, Yvain, Rivas, Deborah Urrutia, Verolet, Charlotte, Villers, Jennifer, Violot, Guillemette, Vuilleumier, Nicolas, Yerly, Sabine, Zaballa, María-Eugenia, Zavlanou, Christina, and Zaballa, Maria-Eugenia

Published
2023
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64. Bien respirer à la maison : l’écocitoyenneté familiale au prisme de la maladie respiratoire chronique de l’enfant

Author

Virginie Loizeau

Subjects
child, family, home, chronic illness, respiratory health, sanitary standards, Ethnology. Social and cultural anthropology, GN301-674, The family. Marriage. Woman, HQ1-2044
Abstract

Research framework: For a family, eco-citizenship means among other things adjusting their domestic practices to their desire to act in favor of the environment and the preservation of its resources. In the event of a child’s chronic respiratory illness, parents receive medical recommendations designed to protect his or her health. These recommendations relate to the layout and upkeep of the home, and concern some of these practices.Objectives: This article aims to show how the family redefines its practices by articulating its values related to health and the environment.Methodology: This research is based on a qualitative study carried out between 2018 and 2020, involving interviews and observations in the homes of 46 families living in Brittany, France, who have a child with cystic fibrosis or asthma. The purpose of the survey was to ethnographically describe domestic hygiene practices, which may stem from values attached to both health and the environment.Results: This article analyzes the dynamics of change in the family’s ecological domestic practices through the prism of the child’s chronic respiratory illness and its implications. It points out the factors influencing the family’s eco-citizen trajectory in this particular context.Conclusion: The inflection given to this trajectory depends first and foremost on the family’s ways of being and doing, and the cultural and social context that shapes them. It then relies on the specific characteristics of the disease, the context in which it is treated and the way in which the medical authority integrates environmental issues into its health guidelines.Contribution: This article looks at children’s chronic respiratory illness as one of the key factors in the construction of a family’s eco-citizenship and its practical implementation. It questions the medical establishment as to how it takes into account environmental values in a perspective of family’s quality of life.

Published
2023

65. Socioeconomic conditions and children's mental health and quality of life during the COVID-19 pandemic: An intersectional analysis

Author

Elsa Lorthe, Viviane Richard, Roxane Dumont, Andrea Loizeau, Javier Perez-Saez, Hélène Baysson, Maria-Eugenia Zaballa, Julien Lamour, Nick Pullen, Stephanie Schrempft, Rémy P. Barbe, Klara M. Posfay-Barbe, Idris Guessous, Silvia Stringhini, Deborah Amrein, Isabelle Arm-Vernez, Andrew S. Azman, Antoine Bal, Michael Balavoine, Julie Berthelot, Patrick Bleich, Livia Boehm, Aminata R. Bouchet, Gaëlle Bryand, Viola Bucolli, Prune Collombet, Alain Cudet, Vladimir Davidovic, Carlos de Mestral, Paola D’Ippolito, Richard Dubos, Isabella Eckerle, Nacira El Merjani, Marion Favier, Natalie Francioli, Clément Graindorge, Munire Hagose, Séverine Harnal, Samia Hurst, Laurent Kaiser, Omar Kherad, Pierre Lescuyer, Arnaud G. L’Huillier, Chantal Martinez, Stéphanie Mermet, Mayssam Nehme, Natacha Noël, Francesco Pennacchio, Anne Perrin, Didier Pittet, Jane Portier, Géraldine Poulain, Caroline Pugin, Frederic Rinaldi, Deborah Rochat, Cyril Sahyoun, Irine Sakvarelidze, Khadija Samir, Hugo Alejandro Santa Ramirez, Jessica Rizzo, Claire Semaani, Stéphanie Testini, Yvain Tisserand, Deborah Urrutia Rivas, Charlotte Verolet, Jennifer Villers, Guillemette Violot, Nicolas Vuilleumier, Sabine Yerly, María-Eugenia Zaballa, and Christina Zavlanou

Subjects
Youth, Adolescents, Socioeconomic disparities, Health equity, MAIHDA, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

Background: Children and adolescents are highly vulnerable to the impact of sustained stressors during developmentally sensitive times. We investigated how demographic characteristics intersect with socioeconomic dimensions to shape the social patterning of quality of life and mental health in children and adolescents, two years into the COVID-19 pandemic. Methods: We used data from the prospective SEROCoV-KIDS cohort study of children and adolescents living in Geneva (Switzerland, 2022). We conducted an intersectional Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy by nesting participants within 48 social strata defined by intersecting sex, age, immigrant background, parental education and financial hardship in Bayesian multilevel logistic models for poor health-related quality of life (HRQoL, measured with PedsQL) and mental health difficulties (measured with the Strengths and Difficulties Questionnaire). Results: Among participants aged 2–17 years, 240/2096 (11.5%, 95%CI 10.1–12.9) had poor HRQoL and 105/2135 (4.9%, 95%CI 4.0–5.9) had mental health difficulties. The predicted proportion of poor HRQoL ranged from 3.4% for 6–11 years old Swiss girls with highly educated parents and no financial hardship to 34.6% for 12–17 years old non-Swiss girls with highly educated parents and financial hardship. Intersectional strata involving adolescents and financial hardship showed substantially worse HRQoL than their counterparts. Between-stratum variations in the predicted frequency of mental health difficulties were limited (range 4.4%–6.5%). Conclusions: We found considerable differences in adverse outcomes across social strata. Our results suggest that, post-pandemic, interventions to address social inequities in HRQoL should focus on specific intersectional strata involving adolescents and families experiencing financial hardship, while those aiming to improve mental health should target all children and adolescents.

Published
2023
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66. Channel capacity enhancement with indefinite causal order

Author

Loizeau, Nicolas and Grinbaum, Alexei

Subjects
Quantum Physics
Abstract

Classical communication capacity of a channel can be enhanced either through a device called a 'quantum switch' or by putting the channel in a quantum superposition. The gains in the two cases, although different, have their origin in the use of a quantum resource, but is it the same resource? Here this question is explored through simulating large sets of random channels. We find that quantum superposition always provides an advantage, while the quantum switch does not: it can either increase or decrease communication capacity. The origin of this discrepancy can be attributed to a subtle combination of superposition and non-commutativity.

Published
2019
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67. Low-energy calibration of XENON1T with an internal 37Ar source

Author

Aprile, E., Abe, K., Agostini, F., Ahmed Maouloud, S., Alfonsi, M., Althueser, L., Andrieu, B., Angelino, E., Angevaare, J. R., Antochi, V. C., Antón Martin, D., Arneodo, F., Baudis, L., Baxter, A. L., Bellagamba, L., Biondi, R., Bismark, A., Brown, A., Bruenner, S., Bruno, G., Budnik, R., Bui, T. K., Cai, C., Capelli, C., Cardoso, J. M. R., Cichon, D., Colijn, A. P., Conrad, J., Cuenca-García, J. J., Cussonneau, J. P., D’Andrea, V., Decowski, M. P., Di Gangi, P., Di Pede, S., Diglio, S., Eitel, K., Elykov, A., Farrell, S., Ferella, A. D., Ferrari, C., Fischer, H., Fulgione, W., Gaemers, P., Gaior, R., Gallo Rosso, A., Galloway, M., Gao, F., Glade-Beucke, R., Grandi, L., Grigat, J., Guida, M., Hammann, R., Higuera, A., Hils, C., Hoetzsch, L., Howlett, J., Iacovacci, M., Itow, Y., Jakob, J., Joerg, F., Joy, A., Kato, N., Kara, M., Kavrigin, P., Kazama, S., Kobayashi, M., Koltman, G., Kopec, A., Kuger, F., Landsman, H., Lang, R. F., Levinson, L., Li, I., Li, S., Liang, S., Lindemann, S., Lindner, M., Liu, K., Loizeau, J., Lombardi, F., Long, J., Lopes, J. A. M., Ma, Y., Macolino, C., Mahlstedt, J., Mancuso, A., Manenti, L., Marignetti, F., Marrodán Undagoitia, T., Martens, K., Masbou, J., Masson, D., Masson, E., Mastroianni, S., Messina, M., Miuchi, K., Mizukoshi, K., Molinario, A., Moriyama, S., Morå, K., Mosbacher, Y., Murra, M., Müller, J., Ni, K., Oberlack, U., Paetsch, B., Palacio, J., Peres, R., Peters, C., Pienaar, J., Pierre, M., Pizzella, V., Plante, G., Qi, J., Qin, J., Ramírez García, D., Reichard, S., Rocchetti, A., Rupp, N., Sanchez, L., Sanchez-Lucas, P., Santos, J. M. F. dos, Sarnoff, I., Sartorelli, G., Schreiner, J., Schulte, D., Schulte, P., Schulze Eißing, H., Schumann, M., Lavina, L. Scotto, Selvi, M., Semeria, F., Shagin, P., Shi, S., Shockley, E., Silva, M., Simgen, H., Takeda, A., Tan, P.-L., Terliuk, A., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Tönnies, F., Valerius, K., Volta, G., Weinheimer, C., Weiss, M., Wenz, D., Wittweg, C., Wolf, T., Xu, D., Xu, Z., Yamashita, M., Yang, L., Ye, J., Yuan, L., Zavattini, G., Zerbo, S., Zhong, M., Zhu, T., Geppert, C., and Riemer, J.

Published
2023
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68. Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome

Author

Bittner, Vera A, Szarek, Michael, Aylward, Philip E, Bhatt, Deepak L, Diaz, Rafael, Edelberg, Jay M, Fras, Zlatko, Goodman, Shaun G, Halvorsen, Sigrun, Hanotin, Corinne, Harrington, Robert A, Jukema, J Wouter, Loizeau, Virginie, Moriarty, Patrick M, Moryusef, Angèle, Pordy, Robert, Roe, Matthew T, Sinnaeve, Peter, Tsimikas, Sotirios, Vogel, Robert, White, Harvey D, Zahger, Doron, Zeiher, Andreas M, Steg, Ph Gabriel, Schwartz, Gregory G, and Committees and Investigators, ODYSSEY OUTCOMES

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Atherosclerosis, Clinical Trials and Supportive Activities, Cardiovascular, Heart Disease - Coronary Heart Disease, Clinical Research, 6.1 Pharmaceuticals, Good Health and Well Being, Acute Coronary Syndrome, Adult, Aged, Antibodies, Monoclonal, Humanized, Cardiovascular Diseases, Cholesterol, LDL, Female, Humans, Lipoprotein(a), Male, Middle Aged, Risk Factors, Treatment Outcome, acute coronary syndromes, alirocumab, low-density lipoprotein cholesterol, major adverse cardiovascular events, proprotein convertase subtilisin/kexin type 9 inhibition, ODYSSEY OUTCOMES Committees and Investigators, major adverse cardiovascular events, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundLipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C).ObjectivesA pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE).MethodsOne to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina.ResultsBaseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081).ConclusionsBaseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).

Published
2020

69. Impact of the COVID-19 pandemic on children and adolescents: determinants and association with quality of life and mental health—a cross-sectional study

Author

Viviane Richard, Roxane Dumont, Elsa Lorthe, Andrea Loizeau, Hélène Baysson, María-Eugenia Zaballa, Francesco Pennacchio, Rémy P. Barbe, Klara M. Posfay-Barbe, Idris Guessous, Silvia Stringhini, and SEROCoV-KIDS Study Group

Subjects
Family factors, Quality of life, Mental health, COVID-19 pandemic, Children, Adolescents, Pediatrics, RJ1-570, Psychiatry, RC435-571
Abstract

Abstract Background The medium-term impact of the COVID-19 pandemic on the wellbeing of children and adolescents remains unclear. More than 2 years into the pandemic, we aimed to quantify the frequency and determinants of having been severely impacted by the COVID-19 pandemic and estimate its impact on health-related quality of life (HRQoL) and mental health. Methods Data was drawn from a population-based cohort of children and adolescents, recruited between December 2021 and June 2022, in Geneva, Switzerland. The Coronavirus impact scale was used to assess the multidimensional impact of the pandemic on children through parent’s report. A score higher than one standard deviation above the mean was deemed a severe impact. Parents additionally reported about their offspring HRQoL and mental health with validated scales. Determinants of having been severely impacted were assessed with logistic models, as were the associations between having experienced a severe impact and poor HRQoL or mental health. Results Out of 2101 participants aged 2–17, 12.7% had experienced a severe pandemic impact. Having a lasting health condition, a pandemic-related worsening of lifestyle habits or an unfavorable family environment were associated with having been severely impacted by the pandemic, while a previous anti-SARS-CoV-2 infection was not. Participants who had experienced a severe pandemic impact were more likely to present poor HRQoL (aOR = 3.1; 95% CI 2.3–4.4) and poor mental health (aOR = 3.9; 95% CI 2.5–6.2). Conclusion The COVID-19 pandemic may have persistent consequences on the wellbeing of children and adolescents, especially among those with health and family vulnerabilities.

Published
2023
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71. A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents

Author

Roxane Dumont, Viviane Richard, Elsa Lorthe, Andrea Loizeau, Francesco Pennacchio, María-Eugenia Zaballa, Hélène Baysson, Mayssam Nehme, Anne Perrin, Arnaud G. L’Huillier, Laurent Kaiser, Rémy P. Barbe, Klara M. Posfay-Barbe, Silvia Stringhini, SEROCoV-KIDS study group, and Idris Guessous

Subjects
Science
Abstract

The post-acute impacts of COVID-19 in children and adolescents are not well understood. In this population-based study in Geneva, the authors find evidence of COVID-19-related symptom persistence beyond 12 weeks in adolescents, and identify chronic conditions and lower socioeconomic status as risk factors.

Published
2022
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72. Effects of sensory deprivation on glomerular interneurons in the mouse olfactory bulb: differences in mortality and phenotypic adjustment of dopaminergic neurons

Author

Alexandra Angelova, Marie-Catherine Tiveron, Mathieu D. Loizeau, Harold Cremer, and Jean-Claude Platel

Subjects
adult neurogenesis, in vivo imaging, sensory deprivation, olfaction, neuronal cell death, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Neurogenesis persists in the mammalian subventricular zone after birth, producing various populations of olfactory bulb (OB) interneurons, including GABAergic and mixed dopaminergic/GABAergic (DA) neurons for the glomerular layer. While olfactory sensory activity is a major factor controlling the integration of new neurons, its impact on specific subtypes is not well understood. In this study we used genetic labeling of defined neuron subsets, in combination with reversible unilateral sensory deprivation and longitudinal in vivo imaging, to examine the behavior of postnatally born glomerular neurons. We find that a small fraction of GABAergic and of DA neurons die after 4 weeks of sensory deprivation while surviving DA-neurons exhibit a substantial decrease in tyrosine hydroxylase (TH) expression levels. Importantly, after reopening of the naris, cell death is arrested and TH levels go back to normal levels, indicating a specific adaptation to the level of sensory activity. We conclude that sensory deprivation induces adjustments in the population of glomerular neurons, involving both, cell death and adaptation of neurotransmitter use in specific neuron types. Our study highlights the dynamic nature of glomerular neurons in response to sensory deprivation and provide valuable insights into the plasticity and adaptability of the olfactory system.

Published
2023
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73. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.

Author

Ray, Kausik K, Colhoun, Helen M, Szarek, Michael, Baccara-Dinet, Marie, Bhatt, Deepak L, Bittner, Vera A, Budaj, Andrzej J, Diaz, Rafael, Goodman, Shaun G, Hanotin, Corinne, Harrington, Robert A, Jukema, J Wouter, Loizeau, Virginie, Lopes, Renato D, Moryusef, Angèle, Murin, Jan, Pordy, Robert, Ristic, Arsen D, Roe, Matthew T, Tuñón, José, White, Harvey D, Zeiher, Andreas M, Schwartz, Gregory G, and Steg, Philippe Gabriel

Abstract

After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4-1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes.ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1-12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65-1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)-defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose-and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials.gov, number NCT01663402.At study baseline, 5444 patients (28·8%) had diabetes, 8246 (43·6%) had prediabetes, and 5234 (27·7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2·20-2·28 mmol/L), after 4 months' treatment with alirocumab (0·80 mmol/L), or after 4 months' treatment with placebo (2·25-2·28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2·8 years was greater in patients with diabetes (16·4%) than in those with prediabetes (9·2%) or normoglycaemia (8·5%); hazard ratio (HR) for diabetes versus normoglycaemia 2·09 (95% CI 1·78-2·46, p

Published
2019

78. Impacts of Long-Term Exposure to Ocean Acidification and Warming on Three-Spined Stickleback (Gasterosteus aculeatus) Growth and Reproduction

Author

Jimmy Devergne, Véronique Loizeau, Christophe Lebigre, Anne Bado-Nilles, Sophie Collet, Olivier Mouchel, Ugo Iaria, Marie-Madeleine Le Gall, Lauriane Madec, Cyril Turiès, and Arianna Servili

Subjects
Gasterosteus aculeatus, climate change, life cycle, sexual maturation, long-term acclimation, lipids, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract

The warming and acidification of surface waters as predicted by the IPCC leads aquatic species to face major multifaceted changes in their environment. Although teleosts have efficient regulatory systems to cope with these changes, such changes clearly have the potential to impact their physiological functions. Hence, it is crucial to estimate the ability of teleost fishes to cope with multi-stresses to predict how they will deal with future environments. In this context, we investigated the joint effect of warming and acidification on three-spined stickleback (Gasterosteus aculeatus) from the juvenile stage to adulthood, focusing on parameters linked to growth, sexual maturation, and reproduction. Juvenile sticklebacks were split in 2 climate scenarios: a “Current” scenario corresponding to the current seasonal physico-chemical parameters of the water of the “Rade de Brest” in France, and a “RCP8.5” scenario with a warming of 3 °C and an acidification of 0.4 pH units. After 7 months, fish in the RCP8.5 scenario reached the same size and mass as those in the Current scenario, but they needed greater amounts of food to reach satiety. Furthermore, the mortality rate over the experiment was higher in the RCP8.5 scenario. Muscle lipid content, an indicator of energy reserves, was lower in females in the RCP8.5 scenario, suggesting an increased need for energy to maintain homeostasis and other physiological functions or a divergence in energy allocation strategy. Moreover, females exhibited lower sexual maturation and egg quality under the RCP8.5 scenario, which could have contributed to the lower fertilisation rate observed. Males were more resilient to the RCP8.5 scenario, exhibiting only a trend for lower kidney somatic index scores. Altogether, these results suggest a delay and/or an inhibition of gametogenesis and maturation in fish in warmed and acidified waters. The analysis of blood sex steroid concentrations, brain gene expression profiles, and physiological indexes did not allow us to discriminate between a delay and an inhibition of maturation in the RCP8.5 scenario. Overall, these findings clearly indicate that there is a long-term global impact of combined acidification and warming on the mortality and reproductive performance of three-spined stickleback.

Published
2023
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79. Preliminary analysis of the Hayabusa2 samples returned from C-type asteroid Ryugu

Author

Yada, Toru, Abe, Masanao, Okada, Tatsuaki, Nakato, Aiko, Yogata, Kasumi, Miyazaki, Akiko, Hatakeda, Kentaro, Kumagai, Kazuya, Nishimura, Masahiro, Hitomi, Yuya, Soejima, Hiromichi, Yoshitake, Miwa, Iwamae, Ayako, Furuya, Shizuho, Uesugi, Masayuki, Karouji, Yuzuru, Usui, Tomohiro, Hayashi, Tasuku, Yamamoto, Daiki, Fukai, Ryota, Sugita, Seiji, Cho, Yuichiro, Yumoto, Koki, Yabe, Yuna, Bibring, Jean-Pierre, Pilorget, Cedric, Hamm, Vincent, Brunetto, Rosario, Riu, Lucie, Lourit, Lionel, Loizeau, Damien, Lequertier, Guillaume, Moussi-Soffys, Aurelie, Tachibana, Shogo, Sawada, Hirotaka, Okazaki, Ryuji, Takano, Yoshinori, Sakamoto, Kanako, Miura, Yayoi N., Yano, Hajime, Ireland, Trevor R., Yamada, Tetsuya, Fujimoto, Masaki, Kitazato, Kohei, Namiki, Noriyuki, Arakawa, Masahiko, Hirata, Naru, Yurimoto, Hisayoshi, Nakamura, Tomoki, Noguchi, Takaaki, Yabuta, Hikaru, Naraoka, Hiroshi, Ito, Motoo, Nakamura, Eizo, Uesugi, Kentaro, Kobayashi, Katsura, Michikami, Tatsuhiro, Kikuchi, Hiroshi, Hirata, Naoyuki, Ishihara, Yoshiaki, Matsumoto, Koji, Noda, Hirotomo, Noguchi, Rina, Shimaki, Yuri, Shirai, Kei, Ogawa, Kazunori, Wada, Koji, Senshu, Hiroki, Yamamoto, Yukio, Morota, Tomokatsu, Honda, Rie, Honda, Chikatoshi, Yokota, Yasuhiro, Matsuoka, Moe, Sakatani, Naoya, Tatsumi, Eri, Miura, Akira, Yamada, Manabu, Fujii, Atsushi, Hirose, Chikako, Hosoda, Satoshi, Ikeda, Hitoshi, Iwata, Takahiro, Kikuchi, Shota, Mimasu, Yuya, Mori, Osamu, Ogawa, Naoko, Ono, Go, Shimada, Takanobu, Soldini, Stefania, Takahashi, Tadateru, Takei, Yuto, Takeuchi, Hiroshi, Tsukizaki, Ryudo, Yoshikawa, Kent, Terui, Fuyuto, Nakazawa, Satoru, Tanaka, Satoshi, Saiki, Takanao, Yoshikawa, Makoto, Watanabe, Sei-ichiro, and Tsuda, Yuichi

Published
2022
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80. First compositional analysis of Ryugu samples by the MicrOmega hyperspectral microscope

Author

Pilorget, C., Okada, T., Hamm, V., Brunetto, R., Yada, T., Loizeau, D., Riu, L., Usui, T., Moussi-Soffys, A., Hatakeda, K., Nakato, A., Yogata, K., Abe, M., Aléon-Toppani, A., Carter, J., Chaigneau, M., Crane, B., Gondet, B., Kumagai, K., Langevin, Y., Lantz, C., Le Pivert-Jolivet, T., Lequertier, G., Lourit, L., Miyazaki, A., Nishimura, M., Poulet, F., Arakawa, M., Hirata, N., Kitazato, K., Nakazawa, S., Namiki, N., Saiki, T., Sugita, S., Tachibana, S., Tanaka, S., Yoshikawa, M., Tsuda, Y., Watanabe, S., and Bibring, J.-P.

Published
2022
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81. The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes

Author

Chirine Rafia, Clément Loizeau, Ophélie Renoult, Christelle Harly, Claire Pecqueur, Noémie Joalland, and Emmanuel Scotet

Subjects
human, Vγ9Vδ2 T lymphocytes, cancer, regulation, TGF-β, Immunologic diseases. Allergy, RC581-607
Abstract

Despite significant advances, the eradication of cancer remains a clinical challenge which justifies the urgent exploration of additional therapeutic strategies such as immunotherapies. Human peripheral Vγ9Vδ2 T cells represent an attractive candidate subset for designing safe, feasible and effective adoptive T cell transfer-based therapies. However, following their infiltration within tumors, γδ T cells are exposed to various regulating constituents and signals from the tumor microenvironment (TME), which severely alter their antitumor functions. Here, we show that TGF-β, whose elevated production in some solid tumors is linked to a poor prognosis, interferes with the antigenic activation of human Vγ9Vδ2 T cells in vitro. This regulatory cytokine strongly impairs their cytolytic activity, which is accompanied by the induction of particular phenotypic, transcriptomic and metabolic changes. Collectively, these observations provide information for better understanding and targeting the impact of TME components to regulate the antitumor activity of human T cell effectors.

Published
2023
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82. World Flora Online : Placing taxonomists at the heart of a definitive and comprehensive global resource on the world's plants

Author

Borsch, Thomas, Berendsohn, Walter, Dalcin, Eduardo, Delmas, Maïté, Demissew, Sebsebe, Elliott, Alan, Fritsch, Peter, Fuchs, Anne, Geltman, Dmitry, Güner, Adil, Haevermans, Thomas, Knapp, Sandra, le Roux, M. Marianne, Loizeau, Pierre-André, Miller, Chuck, Miller, James, Miller, Joseph T., Palese, Raoul, Paton, Alan, Parnell, John, Pendry, Colin, Qin, Hai-Ning, Sosa, Victoria, Sosef, Marc, von Raab-Straube, Eckhard, Ranwashe, Fhatani, Raz, Lauren, Salimov, Rashad, Smets, Erik, Thiers, Barbara, Thomas, Wayt, Tulig, Melissa, Ulate, William, Ung, Visotheary, Watson, Mark, Jackson, Peter Wyse, and Zamora, Nelson

Published
2020

83. The tactile receptive fields of freely moving Caenorhabditis elegans nematodes

Author

Mazzochette, EA, Nekimken, AL, Loizeau, F, Whitworth, J, Huynh, B, Goodman, MB, and Pruitt, BL

Subjects
Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Animals, Animals, Genetically Modified, Behavior, Animal, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Computer Systems, Mechanoreceptors, Mechanotransduction, Cellular, Physical Stimulation, Sensory Receptor Cells, Spectrin, Touch, Medicinal and Biomolecular Chemistry, Pharmacology and Pharmaceutical Sciences, General Science & Technology, Biochemistry and cell biology
Abstract

Sensory neurons embedded in skin are responsible for the sense of touch. In humans and other mammals, touch sensation depends on thousands of diverse somatosensory neurons. By contrast, Caenorhabditis elegans nematodes have six gentle touch receptor neurons linked to simple behaviors. The classical touch assay uses an eyebrow hair to stimulate freely moving C. elegans, evoking evasive behavioral responses. This assay has led to the discovery of genes required for touch sensation, but does not provide control over stimulus strength or position. Here, we present an integrated system for performing automated, quantitative touch assays that circumvents these limitations and incorporates automated measurements of behavioral responses. The Highly Automated Worm Kicker (HAWK) unites a microfabricated silicon force sensor holding a glass bead forming the contact surface and video analysis with real-time force and position control. Using this system, we stimulated animals along the anterior-posterior axis and compared responses in wild-type and spc-1(dn) transgenic animals, which have a touch defect due to expression of a dominant-negative α-spectrin protein fragment. As expected from prior studies, delivering large stimuli anterior and posterior to the mid-point of the body evoked a reversal and a speed-up, respectively. The probability of evoking a response of either kind depended on stimulus strength and location; once initiated, the magnitude and quality of both reversal and speed-up behavioral responses were uncorrelated with stimulus location, strength, or the absence or presence of the spc-1(dn) transgene. Wild-type animals failed to respond when the stimulus was applied near the mid-point. These results show that stimulus strength and location govern the activation of a characteristic motor program and that the C. elegans body surface consists of two receptive fields separated by a gap.

Published
2018

84. Defining an enabling environment for those with chronic disease: an integrative review

Author

Valérie Loizeau, Jean-Manuel Morvillers, Dominique Pougheon Bertrand, Kelley Kilpatrick, and Monique Rothan-Tondeur

Subjects
Chronic illness, Integrative review, Nurse-patient relationship, Nurse roles, Patient participation, Quality of Life., Nursing, RT1-120
Abstract

Abstract Background Health policies are currently being implemented to cope with the 37% of those affected by chronic disease and 63% of deaths worldwide. Among the proposals, there is accelerating support for greater autonomy for patients, which incorporates several concepts, including empowerment. To achieve this, develop an environment to increase an individual’s capacity for action seems to be a fundamental step. The aim of this study is to characterize an enabling environment for patients in the context of chronic disease management. Methods An integrative review design was applied. Medline, CINAHL, and Web of Science databases were searched to identify relevant literature published between 2009 and 2019. Overall, the review process was guided by the PRISMA 2020 checklist. The Mixed Methods Appraisal Tool for quality evaluation was used. Results A total of 40 articles were analyzed, divided into 18 quantitative studies, 11 qualitative studies, two mixed studies, seven expert opinions, one theory and one conference report. The following characteristics defining an enabling environment were taken from the literature relating to those with a chronic condition: Needs assessment-adaptation of responses, supporting “take care”, involvement in support, knowledge improvement, engagement with professionals, use of information and communication technologies, and organization of care. Beyond that, the interactions highlighted between these seven categories characterize an enabling environment. Conclusion This review specifies the essential elements of an enabling environment for patients with chronic conditions. It encompasses the partnership between the healthcare professional, such as the advanced practice nurse, and the individual for whom interventions and care strategies must be devised.

Published
2021
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85. The geography of Oxia Planum

Author

Peter Fawdon, Peter Grindrod, Csilla Orgel, Elliot Sefton-Nash, Solmaz Adeli, Matt Balme, Gabriele Cremonese, Joel Davis, Alessandro Frigeri, Ernst Hauber, Laetitia Le Deit, Damien Loizeau, Andrea Nass, Adam Parks-Bowen, Cathy Quantin-Nataf, Nick Thomas, Jorge L. Vago, and Matthieu Volat

Subjects
exomars, oxia planum, mars, cassis, ctx dem, geography, Maps, G3180-9980
Abstract

We present the geography of Oxia Planum, the landing site for the ExoMars 2022 mission. This map provides the planetary science community with a framework to understand this, until recently, unexplored area. The map comprises (1) a mosaic of the panchromatic Context Camera (CTX) Digital Elevation Models (DEM) and Ortho Rectified Images (ORI) controlled to the High Resolution Stereo Camera (HRSC) multiorbit Digital Elevation Models (DEM) and (2) a mosaic of Colour and Stereo Surface Imaging System (CaSSIS) synthetic colour data products, registered to the CTX ORI mosaic. We define a grid of exploration quadrangles (quads) and an informal group of geographic regions to describe Oxia Planum. These regions bridge the scale gap between features observed on large areas (∼100s km2) and the local geography (10s km2) relevant to the Rosalind Franklin rover’s operations in Oxia Planum.

Published
2021
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89. Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Author

CBM Collaboration, Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Yu., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K. -H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Yu., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, Xu, Cálin, M., Cao, Ping, Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, Hongfang, Chen, LuYao, Cheng, Jianping, Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, Supriya, Das, Susovan, de Cuveland, J., Debnath, B., Dementiev, D., Deng, Wendi, Deng, Zhi, Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, Sheng, Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, Huanhuan, Fan, Xingming, Farooq, M., Fateev, O., Feng, Shengqin, Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., Chávez, C. García, Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Ramírez, A. Gómez, Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Yu., Han, Dong, Hartmann, H., He, Shue, Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, Dongdong, Huang, Guangming, Huang, Xinjie, Hutter, D., Ierusalimov, A., Ilgenfritz, E. -M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, Valery, Ivanov, Victor, Ivanov, Vladimir, Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, Di, Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K. -H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, Ch., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, Ajit, Kumar, Ashwini, Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., García, A. Laso, Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, Cheng, Li, Qiyan, Li, Xin, Li, Yuanjing, Lindenstruth, V., Linnik, B., Liu, Feng, Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P. -A., Lone, S. A., Martínez, J. A. Lucio, Luo, Xiaofeng, Lymanets, A., Lyu, Pengfei, Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Garcia, A. M. Marin, Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Castillo, C. E. Muńoz, Murin, Yu., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, Kunsu, Onishchuk, Yu., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. K., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Rabtsun, S., Radulescu, L., Raha, S., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reinefeld, A., Reshetin, A., Ristea, C., Ristea, O., Rodriguez, A. Rodriguez, Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, Amitava, Roy, Ankhi, Rożynek, J., Ryabov, Yu., Sadovsky, A., Sahoo, R., Sahu, P. K., Sahu, S. K., Saini, J., Samanta, S., Sambyal, S. S., Samsonov, V., Rosado, J. Sánchez, Sander, O., Sarangi, S., Satława, T., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schintke, F., Schmidt, C. J., Schmidt, H. R., Schmidt, K., Scholten, J., Schweda, K., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabanov, A., Shabunov, A., Shao, Ming, Sheremetiev, A. D., Shi, Shusu, Shumeiko, N., Shumikhin, V., Sibiryak, I., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R. N., Singh, A. K., Singh, B. K., Singh, C. P., Singhal, V., Singla, M., Sitzmann, P., Siwek-Wilczyńska, K., Škoda, L., Skwira-Chalot, I., Som, I., Song, Guofeng, Song, Jihye, Sosin, Z., Soyk, D., Staszel, P., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Yongjie, Svirida, D., Svoboda, O., Szabó, A., Szczygieł, R., Talukdar, R., Tang, Zebo, Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M. -G., Teklishyn, M., Tischler, T., Tlustý, P., Tölyhi, T., Toia, A., Topil'skaya, N., Träger, M., Tripathy, S., Tsakov, I., Tsyupa, Yu., Turowiecki, A., Tuturas, N. G., Uhlig, F., Usenko, E., Valin, I., Varga, D., Vassiliev, I., Vasylyev, O., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y. P., Volkov, S., Volochniuk, A., Vorobiev, A., Voronin, Aleksey, Voronin, Alexander, Vovchenko, V., Vznuzdaev, M., Wang, Dong, Wang, Xi-Wei, Wang, Yaping, Wang, Yi, Weber, M., Wendisch, C., Wessels, J. P., Wiebusch, M., Wiechula, J., Wielanek, D., Wieloch, A., Wilms, A., Winckler, N., Winter, M., Wiśniewski, K., Wolf, Gy., Won, Sanguk, Wu, Ke-Jun, Wüstenfeld, J., Xiang, Changzhou, Xu, Nu, Yang, Junfeng, Yang, Rongxing, Yin, Zhongbao, Yoo, In-Kwon, Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Yu., Zamiatin, N. I., Zanevsky, Yu., Zhalov, M., Zhang, Yifei, Zhang, Yu, Zhao, Lei, Zheng, Jiajun, Zheng, Sheng, Zhou, Daicui, Zhou, Jing, Zhu, Xianglei, Zinchenko, A., Zipper, W., Żoładź, M., Zrelov, P., Zryuev, V., Zumbruch, P., and Zyzak, M.

Subjects
Nuclear Experiment
Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter., Comment: 15 pages, 11 figures. Published in European Physical Journal A

Published
2016
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90. Performance studies of MRPC prototypes for CBM

Author

Deppner, I., Herrmann, N., Frühauf, J., Kiš, M., Lyu, P., Loizeau, P. -A., Shi, L., Simon, C., Wang, Y., and Xie, B.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

Multi-gap Resistive Plate Chambers (MRPCs) with multi-strip readout are considered to be the optimal detector candidate for the Time-of-Flight (ToF) wall in the Compressed Baryonic Matter (CBM) experiment. In the R&D phase MRPCs with different granularities, low-resistive materials and high voltage stack configurations were developed and tested. Here, we focus on two prototypes called HD-P2 and THU-strip, both with strips of 27 cm$^2$ length and low-resistive glass electrodes. The HD-P2 prototype has a single-stack configuration with 8 gaps while the THU-strip prototype is constructed in a double-stack configuration with 2 $\times$ 4 gaps. The performance results of these counters in terms of efficiency and time resolution carried out in a test beam time with heavy-ion beam at GSI in 2014 are presented in this proceeding., Comment: 7 pages, 6 figures, to be submitted to JINST

Published
2016
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91. Time and position resolution of high granularity, high counting rate MRPC for the inner zone of the CBM-TOF wall

Author

Petriş, M., Bartoş, D., Caragheorgheopol, G., Deppner, I., Frühauf, J., Herrmann, N., Kiš, M., Loizeau, P-A., Petrovici, M., Rǎdulescu, L., Simion, V., and Simon, C.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Multi-gap RPC prototypes with readout on a multi-strip electrode were developed for the small polar angle region of the CBM-TOF subdetector, the most demanding zone in terms of granularity and counting rate. The prototypes are based on low resistivity ($\sim$10$^{10}$ $\Omega$cm) glass electrodes for performing in high counting rate environment. The strip width/pitch size was chosen such to fulfill the impedance matching with the front-end electronics and the granularity requirements of the innermost zone of the CBM-TOF wall. The in-beam tests using secondary particles produced in heavy ion collisions on a Pb target at SIS18 - GSI Darmstadt and SPS - CERN were focused on the performance of the prototype in conditions similar to the ones expected at SIS100/FAIR. An efficiency larger than 98\% and a system time resolution in the order of 70~-~80~ps were obtained in high counting rate and high multiplicity environment., Comment: 8 pages, 13 figures

Published
2016
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92. Development and test of a real-size MRPC for CBM-TOF

Author

Wang, Yi, Lyu, Pengfei, Huang, Xinjie, Han, Dong, Xie, Bo, Li, Yuanjing, Herrmann, Norbert, Deppner, Ingo, Simon, Christian, Loizeau, Pierre-Alain, Weidenkaff, Philipp, Jochen, Frühau, and Kis, M. Laden

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

In the CBM (Compressed Baryonic Matter) experiment constructed at the Facility for Anti-proton and Ion Research (Fair) at GSI, Darmstadt, Germany, MRPC(Multi-gap Resistive Plate Chamber) is adopted to construct the large TOF (Time-of-Flight) system to achieve an unprecedented precision of hadron identification, benefiting from its good time resolution, relatively high efficiency and low building price. We have developed a kind of double-ended readout strip MRPC. It uses low resistive glass to keep good performance of time resolution under high-rate condition. The differential double stack structure of 2x4 gas gaps help to reduce the required high voltage to half. There are 24 strips on one counter, and each is 270mm long, 7mm wide and the interval is 3mm. Ground is placed onto the MRPC electrode and feed through is carefully designed to match the 100 Ohm impedance of PADI electronics. The prototype of this strip MRPC has been tested with cosmic ray, a 98% efficiency and 60ps time resolution is gotten. In order to further examine the performance of the detector working under higher particle flux rate, the prototype has been tested in the 2014 October GSI beam time and 2015 February CERN beam time. In both beam times a relatively high rate of 1 kHz/cm2 was obtained. The calibration is done with CBM ROOT. A couple of corrections has been considered in the calibration and analysis process (including time-walk correction, gain correction, strip alignment correction and velocity correction) to access actual counter performances such as efficiency and time resolution. An efficiency of 97% and time resolution of 48ps are obtained. All these results show that the real-size prototype is fully capable of the requirement of the CBM-TOF, and new designs such as self-sealing are modified into the strip counter prototype to obtain even better performance.

Published
2016
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93. Persistent symptoms after SARS-CoV-2 infection in children: a cross-sectional population-based serological study

Author

François Chappuis, Silvia Stringhini, Delphine Courvoisier, Idris Guessous, Antoine Flahault, Laurent Kaiser, Andrew S Azman, Didier Pittet, Isabella Eckerle, Carlos de Mestral, Omar Kherad, Benjamin Meyer, Ania Wisniak, Nicolas Vuilleumier, Alexandre Moulin, Elsa Lorthe, Hélène Baysson, Sabine Yerly, Jennifer Villers, Mayssam Nehme, Roxane Dumont, Jean-François Balavoine, Isabelle Arm-Vernez, Delphine Bachmann, Patrick Bleich, Prune Collombet, Nacira El Merjani, Natalie Francioli, Marion Frangville, Séverine Harnal, Pierre Lescuyer, Andrea Jutta Loizeau, Fanny-Blanche Lombard, Chantal Martinez, Ludovic Metral-Boffod, Natacha Noël, Francesco Pennacchio, Javier Perez-Saez, Jane Portier, Géraldine Poulain, Caroline Pugin, Nick Pullen, Zo Francia Randrianandrasana, Aude Richard, Viviane Richard, Guillemette Violot, María-Eugenia Zaballa, Oumar Ba, Fatim Ba, Michael Balavoine, Lison Beigbeder, Julie Berthelot, Alain Cudet, Samia Hurst, Julien Lamour, François L’Huissier, Lucie Ménard, Lakshmi Menon, Frederic Rinaldi, Jessica Rizzo, Khadija Samir, Claire Semaani, Stéphanie Testini, Anne Perrin, Arnaud G L'Huillier, Klara Maria Posfay-Barbe, Antoine Bal, Rémy Barbe, Gaëlle Bryand, Paola Vargas, Richard Dubos D'ippolito, and Deborah Urrutia Rivas

Subjects
Medicine
Abstract

Objectives To estimate the prevalence of children and adolescents reporting persistent symptoms after SARS-CoV-2 infection.Design A random sample of children and adolescents participated with their family members to a serological survey including a blood drawing for detecting antibodies targeting the SARS-CoV-2 nucleocapsid (N) protein and a questionnaire on COVID-19-related symptoms experienced since the beginning of the pandemic.Setting The study took place in the canton of Geneva, Switzerland, between June and July 2021.Participant 660 children aged between 2 and 17 years old.Primary and secondary outcome The primary outcome was the persistence of symptoms beyond 4 weeks comparing seropositive and seronegative participants. The type of declared symptoms were also studied as well as associated risk factors.Results Among seropositive children, the sex-adjusted and age-adjusted prevalence of symptoms lasting longer than 2 weeks was 18.3%, compared with 11.1% among seronegatives (adjusted prevalence difference (ΔaPrev)=7.2%, 95% CI: 1.5% to 13.0%). Among adolescents aged 12–17 years, we estimated the prevalence of experiencing symptoms lasting over 4 weeks to be 4.4% (ΔaPrev,95% CI: −3.8% to 13.6%), whereas no seropositive child aged 2–11 reported symptoms of this duration. The most frequently declared symptoms were fatigue, headache and loss of smell.Conclusions We estimated the prevalence of experiencing persistent symptoms lasting over 4 weeks to be around 4% among adolescents, which represents a large absolute number, and should raise awareness and concern. We did not observe meaningful differences of persistent symptoms between seropositive and seronegative younger children, suggesting that they may be less affected than their older counterparts.

Published
2022
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94. Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol

Author

Schwartz, Gregory G., Gabriel Steg, P.h., Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Goodman, Shaun G., Harrington, Robert A., Jukema, J. Wouter, Szarek, Michael, White, Harvey D., Zeiher, Andreas M., Tricoci, Pierluigi, Roe, Matthew T., Mahaffey, Kenneth W., Edelberg, Jay M., Hanotin, Corinne, Lecorps, Guillaume, Moryusef, Angèle, Pordy, Robert, Sasiela, William J., Tamby, Jean-François, Aylward, Philip E., Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Lopes, Renato D., Gotcheva, Nina N., Prieto, Juan-Carlos, Yong, Huo, López-Jaramillo, Patricio, Pećin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S., Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Montenegro Valdovinos, Pablo Carlos, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Erglis, Andrejs, Laucevicius, Aleksandras, Kedev, Sasko, Yusoff, Khalid, Ramos López, Gabriel Arturo, Alings, Marco, Halvorsen, Sigrun, Correa Flores, Roger M., Sy, Rody G., Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Karpov, Yuri, Ristic, Arsen D., Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J., Tuñón, José, Asita de Silva, H., Hagström, Emil, Landmesser, Ulf, Müller, Christian, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K., Moriarty, Patrick M., Vogel, Robert, Chaitman, Bernard, Kelsey, Sheryl F., Olsson, Anders G., Rouleau, Jean-Lucien, Simoons, Maarten L., Alexander, Karen, Meloni, Chiara, Rosenson, Robert, Sijbrands, Eric J.G., Alexander, John H., Armaganijan, Luciana, Bagai, Akshay, Bahit, Maria Cecilia, Brennan, J. Matthew, Clifton, Shaun, DeVore, Adam D., Deloatch, Shalonda, Dickey, Sheila, Dombrowski, Keith, Ducrocq, Grégory, Eapen, Zubin, Endsley, Patricia, Eppinger, Arleen, Harrison, Robert W., Hess, Connie Ng, Hlatky, Mark A., Jordan, Joseph Dedrick, Knowles, Joshua W., Kolls, Bradley J., Kong, David F., Leonardi, Sergio, Lillis, Linda, Maron, David J., Marcus, Jill, Mathews, Robin, Mehta, Rajendra H., Mentz, Robert J., Moreira, Humberto Graner, Patel, Chetan B., Pereira, Sabrina Bernardez, Perkins, Lynn, Povsic, Thomas J., Puymirat, Etienne, Jones, William Schuyler, Shah, Bimal R., Sherwood, Matthew W., Stringfellow, Kenya, Sujjavanich, Darin, Toma, Mustafa, Trotter, Charlene, van Diepen, Sean F.P., Wilson, Matthew D., Tze-Kay Yan, Andrew, Schiavi, Lilia B., Garrido, Marcelo, Alvarisqueta, Andrés F., Sassone, Sonia A., Bordonava, Anselmo P., Alves De Lima, Alberto E., Schmidberg, Jorge M., Duronto, Ernesto A., Caruso, Orlando C., Novaretto, Leonardo P., Hominal, Miguel Angel, Montaña, Oscar R., Caccavo, Alberto, Gomez Vilamajo, Oscar A., Lorenzatti, Alberto J., Cartasegna, Luis R., Paterlini, Gustavo A., Mackinnon, Ignacio J., Caime, Guillermo D., Amuchastegui, Marcos, Salomone, Oscar, Codutti, Oscar R., Jure, Horacio O., Bono, Julio O.E., Hrabar, Adrian D., Vallejos, Julio A., Ahuad Guerrero, Rodolfo A., Novoa, Federico, Patocchi, Cristian A., Zaidman, Cesar J., Giuliano, Maria E., Dran, Ricardo D., Vico, Marisa L., Carnero, Gabriela S., Guzman, Pablo N., Medrano Allende, Juan C., Garcia Brasca, Daniela F., Bustamante Labarta, Miguel H., Nani, Sebastian, Blumberg, Eduardo D.S., Colombo, Hugo R., Liberman, Alberto, Fuentealba, Victorino, Luciardi, Hector L., Waisman, Gabriel D., Berli, Mario A., Garcia Duran, Ruben O., Cestari, Horacio G., Luquez, Hugo A., Giordano, Jorge A., Saavedra, Silvia S., Zapata, Gerardo, Costamagna, Osvaldo, Llois, Susana, Waites, Jonathon H., Collins, Nicholas, Soward, Allan, Hii, Chris L.S., Shaw, James, Arstall, Margaret A., Horowitz, John, Ninio, Daniel, Rogers, James F., Colquhoun, David, Oqueli Flores, Romulo E., Roberts-Thomson, Philip, Raffel, Owen, Lehman, Sam J., Aroney, Constantine, Coverdale, Steven G.M., Garrahy, Paul J., Starmer, Gregory, Sader, Mark, Carroll, Patrick A., Dick, Ronald, Zweiker, Robert, Hoppe, Uta, Huber, Kurt, Berger, Rudolf, Delle-Karth, Georg, Frey, Bernhard, Faes, Dirk, Hermans, Kurt, Pirenne, Bruno, Leone, Attilio, Hoffer, Etienne, Vrolix, Mathias C.M., De Wolf, Luc, Wollaert, Bart, Castadot, Marc, Dujardin, Karl, Beauloye, Christophe, Vervoort, Geert, Striekwold, Harry, Convens, Carl, Roosen, John, Barbato, Emanuele, Claeys, Marc, Cools, Frank, Terzic, Ibrahim, Barakovic, Fahir, Midzic, Zlatko, Pojskic, Belma, Fazlibegovic, Emir, Durak-Nalbantic, Azra, Kulić, Mehmed, Vulic, Dusko, Muslibegovic, Adis, Goronja, Boris, Reis, Gilmar, Sousa, Luciano, Nicolau, Jose C., Giorgeto, Flavio E., Silva, Ricardo P., Maia, Lilia Nigro, Rech, Rafael, Rossi, Paulo R.F., Cerqueira, Maria José A.G., Duda, Norberto, Kalil, Renato, Kormann, Adrian, Abrantes, José Antonio M., Filho, Pedro Pimentel, Soggia, Ana Priscila, de Santos, Mayler O.N., Neuenschwander, Fernando, Bodanese, Luiz C., Michalaros, Yorghos L., Eliaschewitz, Freddy G., Vidotti, Maria H., Leaes, Paulo E., Botelho, Roberto V., Kaiser, Sergio, Fernandes Manenti, Euler Roberto F., Precoma, Dalton B., Moura Jorge, Jose C., Silva, Pedro, Silveira, Jose A., Saporito, Wladmir, Marin Neto, Jose A., Feitosa, Gilson S., Ritt, Luiz Eduardo F., de Souza, Juliana A., Costa, Fernando, Souza, Weimar K.S.B., Reis, Helder J.L., Machado, Leandro, Aidar Ayoub, José Carlos, Todorov, Georgi V., Nikolov, Fedya P., Velcheva, Elena S., Tzekova, Maria L., Benov, Haralambi O., Petranov, Stanislav L., Tumbev, Haralin S., Shehova-Yankova, Nina S., Markov, Dimitar T., Raev, Dimitar H., Mollov, Mihail N., Kichukov, Kostadin N., Ilieva-Pandeva, Katya A., Ivanova, Raya, Gospodinov, Maryana, Mincheva, Valentina M., Lazov, Petar V., Dimov, Bojidar I., Senaratne, Manohara, Stone, James, Kornder, Jan, Pearce, Stephen, Dion, Danielle, Savard, Daniel, Pesant, Yves, Pandey, Amritanshu, Robinson, Simon, Gosselin, Gilbert, Vizel, Saul, Hoag, Gordon, Bourgeois, Ronald, Morisset, Anne, Sabbah, Eric, Sussex, Bruce, Kouz, Simon, MacDonald, Paul, Diaz, Ariel, Michaud, Nicolas, Fell, David, Leung, Raymond, Vuurmans, Tycho, Lai, Christopher, Nigro, Frank, Davies, Richard, Nogareda, Gustavo, Vijayaraghavan, Ram, Ducas, John, Lepage, Serge, Mehta, Shamir, Cha, James, Dupuis, Robert, Fong, Peter, Lutchmedial, Sohrab, Rodes-Cabau, Josep, Fadlallah, Hussein, Cleveland, David, Huynh, Thao, Bata, Iqbal, Hameed, Adnan, Pincetti, Cristian, Potthoff, Sergio, Prieto, Juan C., Acevedo, Monica, Aguirre, Arnoldo, Vejar, Margarita, Yañez, Mario, Araneda, Guillermo, Fernandez, Mauricio, Perez, Luis, Varleta, Paola, Florenzano, Fernando, Huidobro, Laura, Raffo, Carlos A., Olivares, Claudia, Nahuelpan, Leonardo, Montecinos, Humberto, Chen, Jiyan, Dong, Yugang, Huang, Weijian, Wang, Jianzhong, Huang, Shi'An, Yao, Zhuhua, Li, Xiang, Cui, Lan, Lin, Wenhua, Sun, Yuemin, Wang, Jingfeng, Li, Jianping, Zhang, Xuelian, Zhu, Hong, Chen, Dandan, Huang, Lan, Dong, Shaohong, Su, Guohai, Xu, Biao, Su, Xi, Cheng, Xiaoshu, Lin, Jinxiu, Zong, Wenxia, Li, Huanming, Feng, Yi, Xu, Dingli, Yang, Xinchun, Ke, Yuannan, Lin, Xuefeng, Zhang, Zheng, Zheng, Zeqi, Luo, Zhurong, Chen, Yundai, Ding, Chunhua, Zhong, Yi, Zheng, Yang, Li, Xiaodong, Peng, Daoquan, Zhao, Shuiping, Li, Ying, Liu, Xuebo, Wei, Meng, Liu, Shaowen, Yu, Yihua, Qu, Baiming, Jiang, Weihong, Zhou, Yujie, Zhao, Xingsheng, Yuan, Zuyi, Guo, Ying, Xu, Xiping, Shi, Xubo, Ge, Junbo, Fu, Guosheng, Bai, Feng, Fang, Weiyi, Shou, Xiling, Yang, Xiangjun, Wang, Jian'An, Xiang, Meixiang, Sun, Yingxian, Lu, Qinghua, Zhang, Ruiyan, Zhu, Jianhua, Xu, Yizhou, Fan, Zhongcai, Li, Tianchang, Wu, Chun, Jaramillo, Nicolas, Vallejo, Gregorio Sanchez, Luna Botia, Diana C., Lopez, Rodrigo Botero, Molina De Salazar, Dora I., Cadena Bonfanti, Alberto J., Aroca, Carlos Cotes, Higuera, Juan Diego, Blanquicett, Marco, Barrera Silva, Sandra I., Garcia Lozada, Henry J., Coronel Arroyo, Julian A., Accini Mendoza, Jose L., Fernandez Ruiz, Ricardo L., Quintero Ossa, Alvaro M., Manzur Jatin, Fernando G., Herazo, Aristides Sotomayor, Parada, Jeffrey Castellanos, Arambula, Rafael Suarez, Urina Triana, Miguel A., Fernandez Trujillo, Angela M., Strozzi, Maja, Car, Siniša, Jerić, Melita, Miličić, Davor, Benčić, Martina Lovrić, Pintarić, Hrvoje, Prvulović, Đeiti, Šikić, Jozica, Peršić, Viktor, Mileta, Dean, Štambuk, Kresimir, Babić, Zdravko, Tomulic, Vjekoslav, Lukenda, Josip, Mejic-Krstulovic, Stanka, Starcevic, Boris, Spinar, Jindrich, Horak, David, Velicka, Zdenek, Stasek, Josef, Alan, David, Machova, Vilma, Linhart, Ales, Novotny, Vojtech, Kaucak, Vladimir, Rokyta, Richard, Naplava, Robert, Coufal, Zdenek, Adamkova, Vera, Podpera, Ivo, Zizka, Jiri, Motovska, Zuzana, Marusincova, Ivana, Svab, Premysl, Heinc, Petr, Kuchar, Jiri, Povolny, Petr, Matuska, Jiri, Poulsen, Steen H., Raungaard, Bent, Clemmensen, Peter, Bang, Lia E., May, Ole, Bøttcher, Morten, Hove, Jens D., Frost, Lars, Gislason, Gunnar, Larsen, John, Johansen, Peter Betton, Hald, Flemming, Johansen, Peter, Jeppesen, Jørgen, Nielsen, Tonny, Kristensen, Kjeld S., Walichiewicz, Piotr Maria, Lomholdt, Jens D., Klausen, Ib C., Nielsen, Peter Kaiser, Davidsen, Flemming, Videbaek, Lars, Soots, Mai, Vahula, Veiko, Hedman, Anu, Soopõld, Üllar, Märtsin, Kaja, Jurgenson, Tiina, Kristjan, Arved, Huikuri, Heikki, Pierre Coste, Juhani Airaksinen, Ferrari, Emile, Morel, Olivier, Montalescot, Gilles, Machecourt, Jacques, Barone-Rochette, Gilles, Mansourati, Jacques, Cottin, Yves, Leclercq, Florence, Belhassane, Abdelkader, Delarche, Nicolas, Boccara, Franck, Paganelli, Franck, Clerc, Jérôme, Schiele, Francois, Aboyans, Victor, Probst, Vincent, Berland, Jacques, Lefèvre, Thierry, Citron, Bernard, Khintibidze, Irakli, Shaburishvili, Tamaz, Pagava, Zurab, Ghlonti, Ramaz, Lominadze, Zaza, Khabeishvili, George, Hemetsberger, Rayyan, Edward, Kemala, Rauch-Kröhnert, Ursula, Stratmann, Matthias, Appel, Karl-Friedrich, Schmidt, Ekkehard, Omran, Heyder, Stellbrink, Christoph, Dorsel, Thomas, Lianopoulos, Emmanouil, Vöhringer, Hans Friedrich, Marx, Roger, Zirlik, Andreas, Schellenberg, Detlev, Heitzer, Thomas, Laufs, Ulrich, Werner, Christian, Gielen, Stephan, Nuding, Sebastian, Winkelmann, Bernhard, Behrens, Steffen, Sydow, Karsten, Karakas, Mahir, Simonis, Gregor, Muenzel, Thomas, Werner, Nikos, Leggewie, Stefan, Böcker, Dirk, Braun-Dullaeus, Rüdiger, Toursarkissian, Nicole, Jeserich, Michael, Weißbrodt, Matthias, Schaeufele, Tim, Weil, Joachim, Völler, Heinz, Waltenberger, Johannes, Natour, Mohammed, Schmitt, Susanne, Müller-Wieland, Dirk, Steiner, Stephan, Heidenreich, Lothar, Offers, Elmar, Gremmler, Uwe, Killat, Holger, Rieker, Werner, Patsilinakos, Sotiris, Kartalis, Athanasios, Manolis, Athanassios, Sionis, Dimitrios, Chachalis, Geargios, Skoumas, Ioannis, Athyros, Vasilios, Vardas, Panagiotis, Parthenakis, Frangkiskos, Lekakis, John, Hatzitolios, Apostolos, Fausto Ovando, Sergio R., Arango Benecke, Juan L., Rodriguez De Leon, Edgar R., Yan, Bryan P.Y., Siu, David C.W., Turi, Tibor, Merkely, Bela, Ungi, Imre, Lupkovics, Geza, Nagy, Lajos, Katona, András, Édes, István, Müller, Gábor, Horvath, Iván, Kapin, Tibor, Szigeti, Zsolt, Faluközy, József, Kumbla, Mukund, Sandhu, Manjinder, Annam, Sharath, Proddutur, Naveen Reddy, Regella, Reddy, Premchand, Rajendra K., Mahajan, Ajaykumar, Pawar, Sudhir, Abhyanakar, Atul D., Kerkar, Prafulla, Govinda, Ravishankar A., Oomman, Abraham, Sinha, Dhurjati, Patil, Sachin N., Kahali, Dhiman, Sawhney, Jitendra, Joshi, Abhijeet B., Chaudhary, Sanjeev, Harkut, Pankaj, Guha, Santanu, Porwal, Sanjay, Jujjuru, Srimannarayana, Pothineni, Ramesh B., Monteiro, Minguel R., Khan, Aziz, Iyengar, Shamanna S., Grewal, Jasprakash Singh, Chopda, Manoj, Fulwani, Mahesh C., Patange, Aparna, Sachin, Patil, Chopra, Vijay K., Goyal, Naresh K., Shinde, Rituparna, Manakshe, Gajendra V., Patki, Nitin, Sethi, Sumeet, Munusamy, Vengatesh, Sunil Thanvi, Sunil Karnaand, Adhyapak, Srilakshmi, Patil, Chandrakant, Pandurangi, Ulhas, Mathur, Rishabh, Gupta, Jugal, Kalashetti, Suhas, Bhagwat, Ajit, Raghuraman, Bagirath, Yerra, Shiv Kumar, Bhansali, Prasant, Borse, Rohidas, Rahul, Patil, Das, Srihari, Kumar, Vinay, Abdullakutty, Jabir, Saathe, Shireesh, Palimkar, Priya, Abdullkutty, Jabir, Sathe, Shireesh, Atar, Shaul, Shechter, Michael, Mosseri, Morris, Arbel, Yaron, Ehud, Chorin, Ofer, Havakuk, Lotan, Chaim, Rosenschein, Uri, Katz, Amos, Henkin, Yaakov, Francis, Adi, Klutstein, Marc, Nikolsky, Eugenia, Zukermann, Robert, Turgeman, Yoav, Halabi, Majdi, Marmor, Alon, Kornowski, Ran, Jonas, Michael, Amir, Offer, Hasin, Yonathan, Rozenman, Yoseph, Fuchs, Shmuel, Zvi, Vered, Hussein, Osamah, Gavish, Dov, Vered, Zvi, Caraco, Yoseph, Elias, Mazen, Tov, Naveh, Wolfovitz, Efrat, Lishner, Michael, Elias, Nizar, Piovaccari, Giancarlo, De Pellegrin, Annamaria, Garbelotto, Raffaella, Guardigli, Gabriele, Marco, Valgimigli, Licciardello, Giovanni, Auguadro, Carla, Scalise, Filippo, Cuccia, Claudio, Salvioni, Alessandro, Musumeci, Giuseppe, Senni, Michelle, Calabrò, Paolo, Novo, Salvatore, Faggiano, Pompilio, Metra, Marco, De Cesare, Nicoletta B., Berti, Sergio, Cavallini, Claudio, Puccioni, Enrico, Galvani, Marcello, Tespili, Maurizio, Piatti, Piermarco, Palvarini, Michela, De Luca, Giuseppe, Violini, Roberto, De Leo, Alessandro, Olivari, Zoran, Filardi, Pasquale Perrone, Ferratini, Maurizio, Racca, Vittorio, Dai, Kazuoki, Shimatani, Yuji, Kamiya, Haruo, Ando, Kenji, Takeda, Yoshihiro, Morino, Yoshihiro, Hata, Yoshiki, Kimura, Kazuo, Kishi, Koichi, Michishita, Ichiro, Uehara, Hiroki, Higashikata, Toshinori, Hirayama, Atsushi, Hirooka, Keiji, Doi, Yasuji, Sakagami, Satoru, Taguchi, Shuichi, Koike, Akihiro, Fujinaga, Hiroyuki, Koba, Shinji, Kozuma, Ken, Kawasaki, Tomohiro, Ono, Yujiro, Shimizu, Masatoshi, Katsuda, Yousuke, Wada, Atsuyuki, Shinke, Toshiro, Ako, Junya, Fujii, Kenshi, Takahashi, Toshiyuki, Sakamoto, Tomohiro, Nakao, Koichi, Furukawa, Yutaka, Sugino, Hiroshi, Tamura, Ritsu, Mano, Toshiaki, Uematsu, Masaaki, Utsu, Noriaki, Ito, Kashima, Haraguchi, Takuya, Sato, Katsuhiko, Ueda, Yasunori, Nishibe, Akira, Fujimoto, Kazuteru, Masutani, Motomaru, Yoon, Jung Han, Kim, Hack-Lyoung, Park, Hun Sik, Chae, In-Ho, Kim, Moo Hyun, Jeong, Myung Ho, Rha, Seungwoon, Kim, Chongjin, Kim, Hae Young, Hong, Taekjong, Tahk, Seung-Jea, Kim, Youngkwon, Busmane, Arija, Pontaga, Natalija, Strelnieks, Aldis, Mintale, Iveta, Sime, Iveta, Petrulioniene, Zaneta, Kavaliauskiene, Roma, Jurgaitiene, Ruta, Sakalyte, Gintare, Slapikas, Rimvydas, Norkiene, Sigute, Misonis, Nerijus, Kibarskis, Aleksandras, Kubilius, Raimondas, Bojovski, Stojko, Lozance, Nensi, Kjovkaroski, Aleksandar, Doncovska, Snezana, Ong, Tiong Kiam, Kasim, Sazzli, Maskon, Oteh, Kandasamy, Balachandran, Liew, Houng B., Izani Wan Mohamed, Wan Mohd, Castillo, Armando García, Calvillo, Jorge Carrillo, Campos, Pedro Fajardo, Núñez Fragoso, Juan Carlos, Bayram Llamas, Edmundo Alfredo, Alcocer Gamba, Marco Antonio, Madrigal, Jaime Carranza, González Salas, Luis Gerardo, Rosas, Enrique López, González Díaz, Belinda, Salcido Vázquez, Eduardo, Nacoud Ackar, Alfredo, Antonio Llamas Esperón, Guillermo, Rodolfo Martínez Sánchez, Carlos, Guerrero De Leon, María, Suarez Otero, Rodrigo, Fanghänel Salmón, Guillermo, Pérez Ríos, Jesús Antonio, Garza Ruíz, José Angel, Breedveld, Robert W., Feenema-Aardema, Margriet, Borger-Van Der Burg, Alida, Hoogslag, Pieter A.M., Suryapranata, Harry, Oomen, Antonius, Van Haelst, Paulus, Feenema-Aradema, Margriet, Wiersma, Jacobijne J., Basart, Dirk, Van Der Wal, Ruud M.A., Zwart, Peter, Monraats, Pascalle, Van Kesteren, Henricus, Karalis, Ioannis, Jukema, Johan, Verdel, Gerardus J.E., Brueren, Bart R.G., Troquay, Roland PTh, Viergever, Eric P., Al-Windy, Nadea Y.Y., Bartels, Gerard L., Cornel, Jan H., Hermans, Walter R.M., Herrman, Johannes P.R., Bos, Robert J., Groutars, Reginald G.E.J., Van Der Zwaan, Coenraad C., Kaplan, Refik, Lionarons, Raymond, Ronner, Eelko, Groenemeijer, Bjorn E., Bronzwaer, Patrick N.A., Liem, Anho A.H., Rensing, Bernard J.W.M., Bokern, Marcel J.J.A., Nijmeijer, Remco, Hersbach, Ferry M.R.J., Willems, Frank F., Gosselink, Antonius T.M., Rasoul, Saman, Elliott, John, Wilkins, Gerard, Fisher, Raewyn, Scott, Douglas, Hart, Hamish, Stewart, Ralph, Harding, Scott, Ternouth, Ian, Fisher, Nicholas, Wilson, Samuel, Aitken, Denise, Anscombe, Russell, Davidson, Laura, Tomala, Tadeusz, Nygård, Ottar, Sparby, Jon Arne, Andersen, Kjell, Gullestad, Lars, Jortveit, Jarle, Munk, Peter S., Singsaas, Erlend gyllensten, Hurtig, Ulf, Calderon Ticona, Jorge R., Durand Velasquez, Julio R., Negron Miguel, Sandra A., Sanabria Perez, Enrique S., Carrion Chambilla, Jesus M., Chavez Ayala, Carlos A., Castillo Leon, Reynaldo P., Vargas Gonzales, Rolando J., Hernandez Zuniga, Jose D., Camacho Cosavalente, Luis A., Bravo Mannucci, Jorge E., Landeo, Javier Heredia, Llerena Navarro, Nassip C., Roldan Concha, Yudy M., Rodriguez Chavez, Víctor E., Anchante Hernandez, Henry A., Zea Nunez, Carlos A., Ramos, Walter Mogrovejo, Ferrolino, Arthur, Sy, Rosa Allyn G., Tirador, Louie, Matiga, Generoso, Coching, Raul Martin, Bernan, Alisa, Rogelio, Gregorio, Morales, Dante D., Tan, Edgar, Sulit, Dennis Jose, Wlodarczak, Adrian, Jaworska, Krystyna, Skonieczny, Grzegorz, Pawlowicz, Lidia, Wojewoda, Pawel, Busz-Papiez, Benita, Bednarski, Janusz, Goch, Aleksander, Staneta, Pawel, Dulak, Elzbieta, Saminski, Krzysztof, Krasowski, Wlodzimierz, Sudnik, Wanda, Zurakowski, Aleksander, Skorski, Marcin, Lysek, Roman, Miklaszewicz, Beata, Kubica, Jacek, Lipko, Jan Andrzej, Kostarska-Srokosz, Edyta, Piepiorka, Marek, Drzewiecka, Anna, Sciborski, Ryszard, Stasiewski, Arkadiusz, Blicharski, Tomasz, Bystryk, Leszek, Szpajer, Michal, Korol, Marek, Czerski, 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Chumakova, Galina, Libov, Igor, Voevoda, Mikhail I., Tretyakova, Tatyana V., Baranov, Evgeny, Shustov, Sergey, Yakushin, Sergey, Gordeev, Ivan, Khasanov, Niiaz, Reshetko, Olga, Sotnikova, Tatiana, Molchanova, Olga, Nikolaev, Konstantin, Gapon, Liudmila, Baranova, Elena, Shogenov, Zaur, Kosmachova, Elena, Karpov, Yuriy, Povzun, Anton, Egorova, Liudmila, Tyrenko, Vadim V., Ivanov, Igor G., Ilya, Masterov, Kanorsky, Sergey, Simic, Dragan, Ivanovic, Nikola, Davidovic, Goran, Tasic, Nebojsa, Asanin, Milika R., Stojic, Stevo, Apostolovic, Svetlana R., Ilic, Stevan, Tosic, Biljana Putnikovic, Stankovic, Aleksandar, Arandjelovic, Aleksandra, Radovanovic, Slavica, Todic, Branislava, Balinovac, Jovan, Dincic, Dragan V., Seferovic, Petar, Karadzic, Ana, Dodic, Slobodan, Dimkovic, Sinisa, Jakimov, Tamara, Poh, Kian-Keong, Ong, Hean Yee, I-Shing, Justin Tang, Micko, Karol, Nociar, Jan, Pella, Daniel, Fulop, Peter, Hranai, Marian, Palka, Juraj, Mazur, Juraj, Majercák, Ivan, Dzupina, Andrej, Fazekas, František, Gonsorcik, Jozef, Bugan, Viliam, Selecky, Juraj, Kamensky, Gabriel, Strbova, Jaroslava, Smik, Rudolf, Dukat, Andrej, Olexa, Peter, Žuran, Ivan, Poklukar, Janez, Šuligoj, Nataša Černič, Cevc, Matija, Cyster, Henry P., Ranjith, Naresh, Corbett, Clive, Bayat, Junaid, Makotoko, Ellen Makoali, du Toit Theron, Hendrik, Kapp, Ilse E., de V Basson, Matthys M., Lottering, Hanlie, Van Aswegen, Dina, Van Zyl, Louis J., Sebastian, Peter J., Pillay, Thayabran, Saaiman, Jan A., Commerford, Patrick J., Cassimjee, Soraya, Riaz, Garda, Ebrahim, Iftikhar O., Sarvan, Mahomed, Mynhardt, Joseph H., Reuter, Helmuth, Moodley, Rajendran, Vida, Manuel, Cequier Fillat, Angel R., Peris, Vicente Bodí, Jimenez, Francisco Fuentes, Marín, Francisco, Cruz Fernández, Jose M., Hidalgo Urbano, Rafael Jesus, Gil-Extremera, Blas, Toledo, Pablo, Diz, Fernando Worner, Garcia-Dorado, David, Iñiguez, Andres, Fernández, José Tuñón, Gonzalez-Juanatey, Jose R., Portales, Javier Fernandez, Murillo, Fernando Civeira, Pericas, Laia Matas, Zamorano, Jose Luis, De Mora Martin, Manuel, Cortada, Jordi Bruguera, Alonso Martin, Joaquin J., Serrano Antolin, Jose Maria, De Berrazueta Fernández, José R., Vázquez de Prada, José Antonio, Díaz Fernández, Jose Francisco, García Lledó, José Alberto, Sales, Juan Cosín, Rodriguez, Javier Botas, Tragant, Gabriel Gusi, Benedicto, Amparo, Gonzalez-Juanatey, Carlos, Potau, Mercedes Camprubí, Perez, Ignacio Plaza, De La Tassa, César Morís, Loma-Osorio Rincon, Pablo, Recena, Javier Balaguer, Escudier, Juan M., Payeras, Antonio Coca, Orcajo, Norberto Alonso, Valdivielso, Pedro, Constantine, Godwin, Haniffa, Ruvaiz, Tissera, Nirmali, Amarasekera, Stanley, Ponnamperuma, Chandrike, Fernando, Nimali, Fernando, Kaputella, Jayawardena, Jayanthimala, Wijeyasingam, Santharaj, Ranasinghe, Gotabhaya, Ekanayaka, Ruvan, Mendis, Sepalika, Senaratne, Vajira, Mayurathan, Gnanamoorthy, Rajapaksha, Ajantha, Sirisena, Thilak, Herath, Jagath I., Amarasena, Naomali, Berglund, Stefan, Rasmanis, Gundars, Vedin, Ola, Witt, Nils, Mourtzinis, Georgios, Nicol, Peter, Hansen, Ole, Romeo, Stefano, Jensen, Steen Agergaard, Torstensson, Ingemar, Ahremark, Ulf, Sundelin, Torbjörn, Moccetti, Tiziano, Mach, Francois, Binde, Ronald, Gämperli, Oliver, Tsai, Wei-Chuan, Ueng, Kwo-Chang, Lai, Wen-Ter, Liu, Ming-En, Hwang, Juey-Jen, Yin, Wei-Hsian, Hsieh, I-Chang, Hsieh, Ming-Jer, Lin, Wei Hsiang, Kuo, Jen-Yuan, Huang, Tsuei-Yuan, Fang, Chih-Yuan, Kaewsuwanna, Pinij, Soonfuang, Wasant, Jintapakorn, Woravut, Sukonthasarn, Apichard, Wongpraparut, Nattawut, Sastravaha, Krisada, Sansanayudh, Nakarin, Kehasukcharoen, Wirash, Piyayotai, Dilok, Chotnoparatpat, Paiboon, Camsari, Ahmet, Kultursay, Hakan, Mutlu, Bulent, Ersanli, Murat, Demirtas, Mustafa, Kirma, Cevat, Ural, Ertan, Koldas, Lale, Karpenko, Oleksandr, Prokhorov, Alexander, Vakaluyk, Ihor, Myshanych, Halyna, Reshotko, Dmytro, Batushkin, Valeriy, Rudenko, Leonid, Kovalskyi, Ihor, Kushnir, Mykola, Tseluyko, Vira, Mostovoy, Yuriy, Stanislavchuk, Mykola, Kyiak, Yulian, Karpenko, Yuriy, Malynovsky, Yaroslav, Klantsa, Andriy, Kutniy, Oles, Amosova, Ekaterina, Tashchuk, Viktor, Leshchuk, Oleh, Rishko, Mykola, Kopytsya, Mykola, Yagensky, Andriy, Vatutin, Mykola, Bagriy, Andriy, Barna, Olga M., Ushakov, Olexiy, Dzyak, Georgiy, Goloborodko, Borys, Rudenko, Anatolii, Zheleznyy, Volodymyr, Trevelyan, Jasper, Zaman, Azfar, Lee, Kaeng, Moriarty, Andrew, Aggarwal, Rajesh K., Clifford, Piers, Wong, Yuk-Ki, Iqbal, Syed M.R., Subkovas, Eduardas, Braganza, Denise, Sarkar, David, Storey, Robert, Griffiths, Huw, Mcclure, Sam, Muthusamy, Rangasamy, Smith, Simon, Kurian, John, Levy, Terry, Barr, Craig, Kadr, Honer, Gerber, Robert, Simaitis, Audrius, Soran, Handrean, Mathur, Anthony, Brodison, Adrian, Ayaz, Mohammad, Cheema, Muhammad, Oliver, Richard, Thackray, Simon, Mudawi, Telal, Rahman, Gohar, Sultan, Ayyaz, Reynolds, Timothy, Sharman, David, david Sprigings, Butler, Rob, Wilkinson, Peter, Lip, Gregory Y.H., Halcox, Julian, Gallagher, Sean, Ossei-Gerning, Nicholas, Vardi, Gil, Baldari, Duccio, Brabham, David, Treasure, Charles, II, Dahl, Charles, Palmer, Bruce, Wiseman, Alan, Khan, Abul, Puri, Sanjeev, Mohart, Ann Elizabeth, Ince, Carlos, Flores, Enrique, Wright, Scott, Cheng, Shi-Chi, Rosenberg, Michael, Rogers, William, Jr., Kosinski, Edward, Forgosh, Les, Waltman, Jonathan, Khan, Misal, Shoukfeh, Mohammad, Dagher, Georges, Cambier, Patrick, Lieber, Ira, Kumar, Priya, East, Cara, Krichmar, Perry, Hasan, Mian, White, Lindsey, Knickelbine, Thomas, Haldis, Thomas, Gillespie, Eve, Amidon, Thomas, Suh, David, Arif, Imran, Abdallah, Mouhamad, Akhter, Faiq, Carlson, Eric, D'Urso, Michael, El-Ahdab, Fadi, Nelson, William, Moriarty, Katie, Harris, Barry, Cohen, Steven, Carter, Luther, Doty, Daniel, Sabatino, Kenneth, Haddad, Tariq, Malik, Amir, Rao, Sunder, Mulkay, Angel, Jovin, Ion, Klancke, Kim, Malhotra, Vinay, Devarapalli, Sai K., Koren, Michael, Chandna, Harish, Dodds, George, III, Goraya, Tauqir, Bengston, James, Janik, Matthew, Moran, Joseph, Sumner, Andrew, Kobayashi, John, Davis, William, Yazdani, Shahram, Pasquini, John, Thakkar, Maitreya, Vedere, Amarnath, Leimbach, Wayne, Rider, James, fenton, Sarah, Singh, Narendra, Shah, Anil V., Janosik, Denise, Pepine, Carl, Berman, Brett, Gelormini, Joseph, Daniels, Christopher, Richard, Kerensky, Keating, Friederike, Kondo, Nicholas I., Shetty, Sanjay, Levite, Howard, Waider, Winfried, Takata, Theodore, Abu-Fadel, Mazen, Shah, Vipul, Aggarwal, Rahul, Izzo, Mark, Kumar, Anil, Hattler, Brack, Do, Rose, Link, Chad, Bortnick, Anna, Kinzfogl, George, III, Ghitis, Arnold, Larry, John, Teufel, Edward, Kuhlman, Peter, Mclaurin, Brent, Zhang, Wenwu, Thew, Stephen, Abbas, Jalal, White, Matthew, Islam, Othman, Subherwal, Sumeet, Ranadive, Nandkishore, Vakili, Babak, Gring, Christian, Henderson, David, Schuchard, Timothy, Farhat, Naim, Kline, Geoffrey, Mahal, Sharan, Whitaker, Jack, Speirs, Shawn, Andersen, Rolf, Daboul, Nizar, Horwitz, Phillip, Zahr, Firas, Ponce, George, Jafar, Zubair, Mcgarvey, Joseph, Jr., Panchal, Vipul, Voyce, Stephen, Blok, Thomas, Sheldon, William, Azizad, Masoud M., Schmalfuss, Carsten, Picone, Mark, Pederson, Robert, Herzog, William, Jr., Friedman, Keith, Lindsey, Jason, Nowins, Rosemary, Timothy, Eichenlaub, Leonard, Parilak, Lepor, Norman, El Shahawy, Mahfouz, Weintraub, Howard, Irimpen, Anand, Alonso, Alvaro, May, Wade, Christopher, Daniels, Galski, Thomas, Chu, Alan, Mody, Freny, Ramin, Ebrahimi, Hodes, Zachary, Rossi, Joseph, Rose, Gregory, Fairlamb, James, Lambert, Charles, Jr., Raisinghani, Ajit, Abbate, Antonio, Vetrovec, George, King, Marilyn, Carey, Charles, Gerber, Jaime, Younis, Liwa, Park, Hyeun, Vidovich, Mladen, Knutson, Thomas, Friedman, Dennis, Chaleff, Fred, Loussararian, Arthur, Rozeman, Phillip, Kimmelstiel, Carey, Kuvin, Jeffrey, Silver, Kevin, Foster, Malcolm, Tonnessen, Glen, Espinoza, Andrey, Amlani, Mohamadali, Wali, Andreas, Malozzi, Christopher, Jong, Geert T., Massey, Clara, Wattanakit, Keattiyoat, O'Donnell, Philip J., Singal, Dinesh, Jaffrani, Naseem, Banuru, Sridhar, Fisher, Daniel, Xenakis, Mark, Perlmutter, Neal, Bhagwat, Ravi, Strader, James, Jr., Blonder, Ronald, Akyea-Djamson, Ayim, Labroo, Ajay, Lee, Kwan, Marais, H. John, Claxton, Edmund, Jr., Weiss, Robert, Kathryn, Rohr, Berk, Martin, Rossi, Peter, Joshi, Parag, Khera, Amit, Khaira, Ajit S., Kumkumian, Greg, Lupovitch, Steven, Purow, Joshua, Welka, Stephen, Hoffman, David, Fischer, Stuart, Soroka, Eugene, Eagerton, Donald, Pancholy, Samir, Ray, Michael, Erenrich, Norman, Farrar, Michael, Pollock, Stewart, French, William J., Diamantis, Steve, Guy, Douglas, Gimple, Lawrence, Neustel, Mark, Schwartz, Steven, Pereira, Edward, Albert, Seals, Spriggs, Douglas, Strain, Janet, Mittal, Suneet, Vo, Anthony, Chane, Majed, Hall, Jason, Vijay, Nampalli, Lotun, Kapildeo, Lester, F. Martin, Nahhas, Ahed, Pope, Theodore, Nager, Paul, Vohra, Rakesh, Sharma, Mukesh, Bashir, Riyaz, Ahmed, Hinan, Berlowitz, Michael, Fishberg, Robert, Barrucco, Robert, Yang, Eric, Radin, Michael, Sporn, Daniel, Stapleton, Dwight, Eisenberg, Steven, Landzberg, Joel, Mcgough, Martin, Turk, Samir, Schwartz, Michael, Sundram, P. Sandy, Jain, Diwakar, Zainea, Mark, Bayron, Carlos, Karlsberg, Ronald, Dohad, Suhail, Lui, Henry, Keen, William, Westerhausen, Donald, Jr., Khurana, Sandeep, Agarwal, Himanshu, Birchem, Jessica, Penny, William, Jr., Chang, Mark, Murphy, Sherrill, Henry, John, Schifferdecker ;John M Gilbert, Branislav, Chalavarya, Gopal, Eaton, Charles, Schmedtje, John F., Jr., Christenson, Stuart, Dotani, Imran, Denham, Douglas, Macdonell, Alexander, Gibson, Paul, Rahman, Aref, Al Joundi, Tammam, Assi, Nizar, Conrad, Gary, Kotha, Purushotham, Love, Michael, Giesler, Gregory, Rubenstein, Howard, Gamil, Dawood, Akright, Laura, Krawczyk, Justine, Cobler, Joanne, Wells, Terry, Welker, James, Foster, Robert, Gilmore, Richard, Anderson, Jay, Jacoby, Douglas, Harris, Bill, Gardner, Geraldine, Dandillaya, Ramprasad, Vora, Kishor, Kostis, John, Hunter, John, Laxson, David, Ball, Eric, Egydio, Flavia, Kawakami, Anelise, Oliveira, Janaina, Wozniak, Julianna, Matthews, Alexander, Ratky, Caroline, Valiris, Janine, Berdan, Lisa, Hepditch, Anita, Quintero, Kirby, Rorick, Tyrus, Westbrook, Melissa, Pascual, Andrea, Rovito, Carla, Bezault, Madeleine, Drouet, Elodie, Simon, Tabassome, Alsweiler, Caroline, Luyten, Anne, Butters, Julie, Griffith, Liddy, Shaw, Michelle, Grunberg, Lena, Islam, Shahidul, Brégeault, Marie-France, Bougon, Nathalie, Faustino, Douglas, Fontecave, Sylvie, Murphy, Judith, Verrier, Melanie, Veronique Agnetti, Andersen, Dorthe, Badreddine, Emmy, Bekkouche, Mhamed, Bouancheau, Cecile, Brigui, Imane, Brocklehurst, Maddy, Cianciarulo, Joseph, Devaul, Dawn, Domokos, Szilvia, Gache, Cecile, Gobillot, Caroline, Guillou, Severine, Healy, Jan, Heath, Megan, Jaiwal, Gayatri, Javierre, Carine, Labeirie, Julien, Monier, Myriam, Morales, Ulises, Mrabti, Asmaa, Mthombeni, Bicky, Okan, Betim, Smith, Lucile, Sheller, Jennifer, Sopena, Sebastien, Pellan, Valerie, Benbernou, Fadela, Bengrait, Nafissa, Lamoureux, Maud, Kralova, Katarina, Scemama, Michel, Bejuit, Raphael, Coulange, Anthony, Berthou, Christelle, Repincay, Jérôme, Lorenzato, Christelle, Etienne, Alexis, Gouet, Valerie, Loizeau, Virginie, Normand, Mickael, Ourliac, Anne, Rondel, Christelle, Adamo, Antony, Beltran, Pascale, Barraud, Pauline, Dubois-Gache, Helene, Halle, Benjamin, Metwally, Lamia, Mourgues, Maxime, Sotty, Marc, Vincendet, Marion, Cotruta, Raluca, Chengyue, Zhu, Fournie-Lloret, Dominique, Morrello, Christine, Perthuis, Aurelie, Picault, Patrick, Zobouyan, Isabelle, Colhoun, Helen M., Dempsey, Michael A., McClanahan, Mark A., Manvelian, Garen, Sinnaeve, Peter R., and Gabriel Steg, Ph

Published
2021
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95. Rise time reduction of thermal actuators operated in air and water through optimized pre-shaped open-loop driving

Author

Larsen, T, Doll, JC, Loizeau, F, Hosseini, N, Peng, AW, Fantner, GE, Ricci, AJ, and Pruitt, BL

Subjects
Control Engineering, Mechatronics and Robotics, Engineering, thermal actuators, system dynamics, cantilever, rise time reduction, Technology, Nanoscience & Nanotechnology
Abstract

Electrothermal actuators have many advantages compared to other actuators used in Micro-Electro-Mechanical Systems (MEMS). They are simple to design, easy to fabricate and provide large displacements at low voltages. Low voltages enable less stringent passivation requirements for operation in liquid. Despite these advantages, thermal actuation is typically limited to a few kHz bandwidth when using step inputs due to its intrinsic thermal time constant. However, the use of pre-shaped input signals offers a route for reducing the rise time of these actuators by orders of magnitude. We started with an electrothermally actuated cantilever having an initial 10-90% rise time of 85 μs in air and 234 μs in water for a standard open-loop step input. We experimentally characterized the linearity and frequency response of the cantilever when operated in air and water, allowing us to obtain transfer functions for the two cases. We used these transfer functions, along with functions describing desired reduced rise-time system responses, to numerically simulate the required input signals. Using these pre-shaped input signals, we improved the open-loop 10-90% rise time from 85 μs to 3 μs in air and from 234 μs to 5 μs in water, an improvement by a factor of 28 and 47, respectively. Using this simple control strategy for MEMS electrothermal actuators makes them an attractive alternative to other high speed micromechanical actuators such as piezoelectric stacks or electrostatic comb structures which are more complex to design, fabricate, or operate.

Published
2017

96. Microfabricated electrochemical gas sensor

Author

Gross, Pierre‐Alexandre, Larsen, Tom, Loizeau, Frédéric, Jaramillo, Thomas, Spitzer, Denis, and Pruitt, Beth

Subjects
carbon compounds, microfabrication, electrochemical sensors, gas sensors, electrochemical electrodes, oxidation, reduction, ion exchange, membranes, spin coating, adhesion, dissociation, voltammetry, microfabricated electrochemical gas sensor, direct gas phase detection, organic molecule, electrode, redox reaction, ion exchange membrane, proton exchange membrane, spin-coated Nafion layer, underlying SU-8 layer, water reservoir, electrochemical property, pollutant, cyclic voltammetry, CO, Engineering, Technology, Nanoscience & Nanotechnology
Published
2016

97. The high-resolution map of Oxia Planum, Mars; the landing site of the ExoMars Rosalind Franklin rover mission

Author

European Space Agency, Centre National D'Etudes Spatiales (France), U.S. Geological Survey, Centre National de la Recherche Scientifique (France), University of Bern, European Commission, UK Space Agency, Istituto Nazionale di Astrofisica, Ministerio de Economía y Competitividad (España), University of Arizona, National Aeronautics and Space Administration (US), Ministry of Education and Science of the Russian Federation, Agencia Estatal de Investigación (España), Science and Technology Facilities Council (UK), Agenzia Spaziale Italiana, Martin-Torres, Javier [0000-0001-6479-2236], Zorzano, Maria-Paz [0000-0002-4492-9650], Fawdon, Peter, Orgel, Csilla, Adeli, Solmaz, Balme, Matt, Calef, Fred J., Davis, Joel M., Frigeri, Alessandro, Grindrod, Peter, Hauber, Ernst, Deit, Laetitia Le, Loizeau, Damien, Nass, Andrea, Quantin-Nataf, Cathy, Sefton-Nash, Elliot, Thomas, Nick, Torres, Ines, Vago, Jorge L., Volat, Matthieu, De Witte, Sander, Altieri, Francesca, Apuzzo, Andrea, Aramendia, Julene, Arana, Gorka, Singh Bahia, Rickbir, Banham, Steven G., Barnes, Robert, Barrett, Alexander M., Benedix, Wolf-Stefan, Bhardwaj, Anshuman, Boazman, Sarah Jane, Bontognali, Tomaso R. R., Bridges, John, Bultel, Benjamin, Ciarletti, Valérie, De Sanctis, Maria Cristina, Dickeson, Zach, Favaro, Elena A., Ferrari, Marco, Foucher, Frédéric, Goetz, Walter, Haldemann, Albert F. C., Harrington, Elise, Kapatza, Angeliki, Koschny, Detlef, Krzesinska, Agata M., Le Gall, Alice, Lewis, Stephen R., Lim, Tanya, Madariaga, Juan Manuel, Man, Benjamin James, Mandon, Lucia, Mangold, Nicolas, Martin-Torres, Javier, McNeil, Joseph D., Molina-Jurado, Antonio, Moral, Andoni G., Motaghian, Sara, Nikiforov, Sergei, Oudart, Nicolas, Pacifici, Andrea, Parkes Bowen, Adam, Plettemeier, Dirk, Poulakis, Pantelis, Putri, Alfiah Rizky Diana, Ruesch, Ottaviano, Sam, Lydia, Schröder, Christian, Statz, Christoph, Thomas, Rebecca, Tirsch, Daniela, Toth, Zsuzsanna, Turner, Stuart, Voelker, Martin, Werner, Stephanie C., Westall, Frances, Whiteside, Barry J., Williams, Adam, Williams, Rebecca M. E., Wright, Jack, Zorzano, Maria-Paz, European Space Agency, Centre National D'Etudes Spatiales (France), U.S. Geological Survey, Centre National de la Recherche Scientifique (France), University of Bern, European Commission, UK Space Agency, Istituto Nazionale di Astrofisica, Ministerio de Economía y Competitividad (España), University of Arizona, National Aeronautics and Space Administration (US), Ministry of Education and Science of the Russian Federation, Agencia Estatal de Investigación (España), Science and Technology Facilities Council (UK), Agenzia Spaziale Italiana, Martin-Torres, Javier [0000-0001-6479-2236], Zorzano, Maria-Paz [0000-0002-4492-9650], Fawdon, Peter, Orgel, Csilla, Adeli, Solmaz, Balme, Matt, Calef, Fred J., Davis, Joel M., Frigeri, Alessandro, Grindrod, Peter, Hauber, Ernst, Deit, Laetitia Le, Loizeau, Damien, Nass, Andrea, Quantin-Nataf, Cathy, Sefton-Nash, Elliot, Thomas, Nick, Torres, Ines, Vago, Jorge L., Volat, Matthieu, De Witte, Sander, Altieri, Francesca, Apuzzo, Andrea, Aramendia, Julene, Arana, Gorka, Singh Bahia, Rickbir, Banham, Steven G., Barnes, Robert, Barrett, Alexander M., Benedix, Wolf-Stefan, Bhardwaj, Anshuman, Boazman, Sarah Jane, Bontognali, Tomaso R. R., Bridges, John, Bultel, Benjamin, Ciarletti, Valérie, De Sanctis, Maria Cristina, Dickeson, Zach, Favaro, Elena A., Ferrari, Marco, Foucher, Frédéric, Goetz, Walter, Haldemann, Albert F. C., Harrington, Elise, Kapatza, Angeliki, Koschny, Detlef, Krzesinska, Agata M., Le Gall, Alice, Lewis, Stephen R., Lim, Tanya, Madariaga, Juan Manuel, Man, Benjamin James, Mandon, Lucia, Mangold, Nicolas, Martin-Torres, Javier, McNeil, Joseph D., Molina-Jurado, Antonio, Moral, Andoni G., Motaghian, Sara, Nikiforov, Sergei, Oudart, Nicolas, Pacifici, Andrea, Parkes Bowen, Adam, Plettemeier, Dirk, Poulakis, Pantelis, Putri, Alfiah Rizky Diana, Ruesch, Ottaviano, Sam, Lydia, Schröder, Christian, Statz, Christoph, Thomas, Rebecca, Tirsch, Daniela, Toth, Zsuzsanna, Turner, Stuart, Voelker, Martin, Werner, Stephanie C., Westall, Frances, Whiteside, Barry J., Williams, Adam, Williams, Rebecca M. E., Wright, Jack, and Zorzano, Maria-Paz

Abstract

This 1:30,000 scale geological map describes Oxia Planum, Mars, the landing site for the ExoMars Rosalind Franklin rover mission. The map represents our current understanding of bedrock units and their relationships prior to Rosalind Franklin’s exploration of this location. The map details 15 bedrock units organised into 6 groups and 7 textural and surficial units. The bedrock units were identified using visible and near-infrared remote sensing datasets. The objectives of this map are (i) to identify where the most astrobiologically relevant rocks are likely to be found, (ii) to show where hypotheses about their geological context (within Oxia Planum and in the wider geological history of Mars) can be tested, (iii) to inform both the long-term (hundreds of metres to ∼1 km) and the short-term (tens of metres) activity planning for rover exploration, and (iv) to allow the samples analysed by the rover to be interpreted within their regional geological context.

Published
2024

98. Provider adherence to training components from the Trial to Reduce Antimicrobial use In Nursing home residents with Alzheimer's disease and other Dementias (TRAIN-AD) intervention

Author

Meghan Hendricksen, Andrea J. Loizeau, Daniel A. Habtemariam, Ruth A. Anderson, Laura C. Hanson, Erika M.C. D'Agata, and Susan L. Mitchell

Subjects
Dementia, Palliative care, Nursing homes, Infections, Antimicrobials, Trial adherence, Medicine (General), R5-920
Abstract

Background: The Trial to Reduce Antimicrobial use In Nursing home residents with Alzheimer's disease and other Dementias (TRAIN-AD) was a cluster randomized clinical trial evaluating a multicomponent program to improve infection management among residents with advanced dementia. This report examines facility and provider characteristics associated with greater adherence to training components of the TRAIN-AD intervention. Methods: Logistic regression was used to identify facility and provider characteristics associated with: 1. Training seminar attendance, 2. Online course completion, and 3. Overall adherence, defined as participation in neither seminar nor course, either seminar or course, or both seminar and course. Results: Among 380 participating providers (nurses, N = 298; prescribing providers, N = 82) almost all (93%) participated in at least one training activity. Being a nurse was associated with higher likelihood of any seminar attendance (adjusted odds ratio (AOR) 5.37; 95% confidence interval (CI), 2.80–10.90). Providers who were in facilities when implementation begun (AOR, 3.01; 95% CI, 1.34–6.78) and in facilities with better quality ratings (AOR, 2.70; 95% CI, 1.59–4.57) were more likely to complete the online course. Prevalent participation (AOR, 2.01; 95% CI, 1.02–3.96) and higher facility quality (AOR, 2.44; 95% CI, 1.27–4.66) were also significantly associated with greater adherence to either seminar or online course. Conclusion: TRAIN-AD demonstrates feasibility in achieving high participation among nursing home providers in intervention training activities. Findings also suggest opportunities to maximize adherence, such as enhancing training efforts in lower quality facilities and targeting of providers who join the facility after implementation start-up.

Published
2022
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100. Associations Between Healthy Behaviors and Persistently Favorable Self-Rated Health in a Longitudinal Population-Based Study in Switzerland.

Author

Nehme, Mayssam, Schrempft, Stephanie, Baysson, Helene, Pullen, Nick, Rouzinov, Serguei, Stringhini, Silvia, Bal, Antoine, Bouhet, Aminata Rosalie, D'ippolito, Paola, Dumont, Roxane, Merjani, Nacira El, Francioli, Natalie, Harnal, Severine, Joost, Stephane, Kathari, Gabriel, Lamour, Julien, Loizeau, Andrea Jutta, Lorthe, Elsa, Martinez, Chantal, and Mecoullam, Shannon

Subjects
HEALTH behavior, COVID-19 pandemic, SLEEP quality, HEALTH status indicators, SCREEN time, LONGITUDINAL method
Abstract

Background: Self-rated health is a subjective yet valuable indicator of overall health status, influenced by various factors including physical, psychological, and socio-economic elements. Self-rated health could be telling and used by primary care physicians to evaluate overall present and predictive health. Design: This study investigates the longitudinal evolution of self-rated health in Switzerland during the COVID-19 pandemic, focusing on the association of persistently favorable self-rated health with various predictors. Participants: This study based on the Specchio cohort, a population-based digital study in Geneva Switzerland, involved participants completing questionnaires from 2021 to 2023. Main Measures: Self-rated health was assessed alongside factors like physical and mental health, socio-economic status, and lifestyle behaviors. Key Results: The study included 7006 participants in 2021, and 3888 participants who answered all three follow-ups (2021, 2022, and 2023). At baseline, 34.9% of individuals reported very good, 54.6% reported good, 9.6% reported average, and 1.0% reported poor to very poor self-rated health. Overall, 29.1% had a worsening in their self-rated health between 2021 and 2023. A subset of participants (12.1%) maintained very good self-rated health throughout, demonstrating persistently favorable self-rated health during the COVID-19 pandemic. Positive health behaviors were associated with persistently favorable self-rated health (exercise aOR 1.13 [1.03–1.24]; healthy diet aOR 2.14 [1.70–2.68]; less screen time aOR 1.28 [1.03–1.58]; and better sleep quality aOR 2.48 [2.02–3.04]). Mental health and social support also played significant roles. Conclusion: The study underscores the significance of healthy lifestyle choices and social support in maintaining favorable self-rated health, particularly during challenging times like the COVID-19 pandemic. Primary care physicians should focus on promoting these factors, integrating these actions in their routine consultations, and advising patients to undertake in socially engaging activities to improve overall health perceptions and outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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