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51. Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98) E411A in complex with blood group A (BgA II) tetrasaccharide

Author

Owen, C.D., primary, Wu, H., additional, Crost, E.H., additional, van Bakel, W., additional, Gascuena, A.M., additional, Latousakis, D., additional, Hicks, T., additional, Walpole, S., additional, Urbanowicz, P.A., additional, Ndeh, D., additional, Monaco, S., additional, Salom, L.S., additional, Griffiths, R., additional, Colvile, A., additional, Spencer, D.I.R., additional, Walsh, M.A., additional, Angulo, J., additional, and Juge, N., additional

Published
2022
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52. Peri-Operative Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Cardiac and Thoracic Surgery

Author

Bianchini S., Nicoletti L., Monaco S., Rigotti E., Corbelli A., Colombari A., Auriti C., Caminiti C., Conti G., De Luca M., Dona D., Galli L., Garazzino S., Inserra A., La Grutta S., Lancella L., Lima M., Lo Vecchio A., Pelizzo G., Petrosillo N., Piacentini G., Pietrasanta C., Principi N., Puntoni M., Simonini A., Tesoro S., Venturini E., Staiano A., Caramelli F., Gargiulo G.D., and Esposito S.

Subjects
surgical antibiotic prophylaxis, ECMO, thoracic surgery, cardiac surgery, pediatric infectious diseases, antibiotics
Abstract

Surgical site infections (SSIs) represent a potential complication of surgical procedures, with a significant impact on mortality, morbidity, and healthcare costs. Patients undergoing cardiac surgery and thoracic surgery are often considered patients at high risk of developing SSIs. This consensus document aims to provide information on the management of peri-operative antibiotic prophylaxis for the pediatric and neonatal population undergoing cardiac and non-cardiac thoracic surgery. The following scenarios were considered: (1) cardiac surgery for the correction of congenital heart disease and/or valve surgery; (2) cardiac catheterization without the placement of prosthetic material; (3) cardiac catheterization with the placement of prosthetic material; (4) implantable cardiac defibrillator or epicardial pacemaker placement; (5) patients undergoing ExtraCorporal Membrane Oxygenation; (6) cardiac tumors and heart transplantation; (7) non-cardiac thoracic surgery with tho-racotomy; (8) non-cardiac thoracic surgery using video-assisted thoracoscopy; (9) elective chest drain placement in the pediatric patient; (10) elective chest drain placement in the newborn; (11) thoracic drain placement in the trauma setting. This consensus provides clear and shared indications, repre-senting the most complete and up-to-date collection of practice recommendations in pediatric cardiac and thoracic surgery, in order to guide physicians in the management of the patient, standardizing approaches and avoiding the abuse and misuse of antibiotics.

Published
2022
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53. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author

Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.

Subjects
Stent, Acute stroke, Settore MED/37 - Neuroradiologia, Acute stroke Internal carotid artery diseases Stent Thrombectomy, Neurology (clinical), General Medicine, Settore MED/26, Internal carotid artery diseases, Thrombectomy
Abstract

The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.

Published
2022

54. Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation

Author

Polymeris, A. A., Macha, K., Paciaroni, M., Wilson, D., Koga, M., Cappellari, M., Schaedelin, S., Zietz, A., Peters, N., Seiffge, D. J., Haupenthal, D., Gassmann, L., De Marchis, G. M., Wang, R., Gensicke, H., Stoll, S., Thilemann, S., Avramiotis, N. S., Bonetti, B., Tsivgoulis, G., Ambler, G., Alberti, A., Yoshimura, S., Brown, M. M., Shiozawa, M., Lip, G. Y. H., Venti, M., Acciarresi, M., Tanaka, K., Mosconi, M. G., Takagi, M., Jager, R. H., Muir, K., Inoue, M., Schwab, S., Bonati, L. H., Lyrer, P. A., Toyoda, K., Caso, V., Werring, D. J., Kallmunzer, B., Engelter, S. T., Traenka, C., Hert, L., Wagner, B., Schaub, F., Meya, L., Fladt, J., Dittrich, T., Fisch, U., Volbers, B., Siedler, G., Bovi, P., Tomelleri, G., Micheletti, N., Zivelonghi, C., Emiliani, A., Parry-Jones, A., Patterson, C., Price, C., Elmarimi, A., Parry, A., Nallasivam, A., Nor, A. M., Esis, B., Bruce, D., Bhaskaran, B., Roffe, C., Cullen, C., Holmes, C., Cohen, D., Hargroves, D., Mangion, D., Chadha, D., Vahidassr, D., Manawadu, D., Giallombardo, E., Warburton, E., Flossman, E., Gunathilagan, G., Proschel, H., Emsley, H., Anwar, I., Burger, I., Okwera, J., Putterill, J., O'Connell, J., Bamford, J., Corrigan, J., Scott, J., Birns, J., Kee, K., Saastamoinen, K., Pasco, K., Dani, K., Sekaran, L., Choy, L., Iveson, L., Mamun, M., Sajid, M., Cooper, M., Burn, M., Smith, M., Power, M., Davis, M., Smyth, N., Veltkamp, R., Sharma, P., Guyler, P., O'Mahony, P., Wilkinson, P., Datta, P., Aghoram, P., Marsh, R., Luder, R., Meenakishundaram, S., Subramonian, S., Leach, S., Ispoglou, S., Andole, S., England, T., Manoj, A., Harrington, F., Rehman, H., Sword, J., Staals, J., Mahawish, K., Harkness, K., Shaw, L., Mccormich, M., Sprigg, N., Mansoor, S., Krishnamurthy, V., Giustozzi, M., Agnelli, G., Becattini, C., D'Amore, C., Cimini, L. A., Bandini, F., Liantinioti, C., Chondrogianni, M., Yaghi, S., Furie, K. L., Tadi, P., Zedde, M., Abdul-Rahim, A. H., Lees, K. R., Carletti, M., Rigatelli, A., Putaala, J., Tomppo, L., Tatlisumak, T., Marcheselli, S., Pezzini, A., Poli, L., Padovani, A., Vannucchi, V., Masotti, L., Sohn, S. -I., Lorenzini, G., Tassi, R., Guideri, F., Acampa, M., Martini, G., Ntaios, G., Athanasakis, G., Makaritsis, K., Karagkiozi, E., Vadikolias, K., Mumoli, N., Galati, F., Sacco, S., Tiseo, C., Corea, F., Ageno, W., Bellesini, M., Colombo, G., Silvestrelli, G., Ciccone, A., Lanari, A., Scoditti, U., Denti, L., Mancuso, M., Maccarrone, M., Ulivi, L., Orlandi, G., Giannini, N., Tassinari, T., De Lodovici, M. L., Rueckert, C., Baldi, A., Toni, D., Letteri, F., Pieroni, A., Giuntini, M., Lotti, E. M., Flomin, Y., Kargiotis, O., Karapanayiotides, T., Monaco, S., Baronello, M. M., Csiba, L., Szabo, L., Chiti, A., Giorli, E., Del Sette, M., Imberti, D., Zabzuni, D., Doronin, B., Volodina, V., Michel, P., Vanacker, P., Barlinn, K., Pallesen, L. -P., Barlinn, J., Deleu, D., Melikyan, G., Ibrahim, F., Akhtar, N., Gourbali, V., Todo, K., Kimura, K., Shibazaki, K., Yagita, Y., Furui, E., Itabashi, R., Terasaki, T., Shiokawa, Y., Hirano, T., Suzuki, R., Kamiyama, K., Nakagawara, J., Takizawa, S., Homma, K., Okuda, S., Okada, Y., Maeda, K., Kameda, T., Kario, K., Nagakane, Y., Hasegawa, Y., Akiyama, H., Shibuya, S., Mochizuki, H., Ito, Y., Nakashima, T., Matsuoka, H., Takamatsu, K., Nishiyama, K., Endo, K., Miyagi, T., Osaki, M., Kobayashi, J., Okata, T., Tanaka, E., Sakamoto, Y., Tokunaga, K., Takizawa, H., Takasugi, J., Matsubara, S., Higashida, K., Matsuki, T., Kinoshita, N., Ide, T., Yoshimoto, T., Ando, D., Fujita, K., Kumamoto, M., Kamimura, T., Kikuno, M., Mizoguchi, T., and Sato, T.

Subjects
Male, medicine.medical_specialty, Vitamin K, medicine.drug_class, 610 Medicine & health, Aged, 80 and over, Atrial Fibrillation, Factor Xa Inhibitors, Female, Humans, Stroke, Continuous variable, Internal medicine, 80 and over, medicine, Aged, Proportional hazards model, business.industry, Anticoagulant, Confounding, Atrial fibrillation, Patient data, medicine.disease, Oldest old, Neurology, Neurology (clinical), 610 Medizin und Gesundheit, business
Abstract

Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (≥85y = 0.65, 95%-CI [0.52, 0.81]) and < 85 years (HR = 0.79, 95%-CI [0.66, 0.95]) in simple (p interaction = 0.129), adjusted (p interaction = 0.094) or weighted (p interaction = 0.512) models. Analyses on recurrent stroke, ICH and death separately were consistent with the primary analysis, as were sensitivity analyses using age dichotomized at 90 years and as a continuous variable. DOAC had a similar net clinical benefit in patients aged ≥85 (+1.73 to +2.66) and < 85 years (+1.90 to +3.36 events/100 patient-years for ICH-weights 1.5 to 3.1). Interpretation: The favorable profile of DOAC over VKA in patients with AF and recent stroke was maintained in the oldest old. ANN NEUROL 2021.

Published
2022
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55. Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation

Author

Polymeris, A.A. Macha, K. Paciaroni, M. Wilson, D. Koga, M. Cappellari, M. Schaedelin, S. Zietz, A. Peters, N. Seiffge, D.J. Haupenthal, D. Gassmann, L. De Marchis, G.M. Wang, R. Gensicke, H. Stoll, S. Thilemann, S. Avramiotis, N.S. Bonetti, B. Tsivgoulis, G. Ambler, G. Alberti, A. Yoshimura, S. Brown, M.M. Shiozawa, M. Lip, G.Y.H. Venti, M. Acciarresi, M. Tanaka, K. Mosconi, M.G. Takagi, M. Jäger, R.H. Muir, K. Inoue, M. Schwab, S. Bonati, L.H. Lyrer, P.A. Toyoda, K. Caso, V. Werring, D.J. Kallmünzer, B. Engelter, S.T. Engelter, S.T. Lyrer, P.A. Bonati, L.H. Seiffge, D.J. Traenka, C. Polymeris, A.A. Zietz, A. Peters, N. De Marchis, G.M. Thilemann, S. Avramiotis, N.S. Gensicke, H. Hert, L. Wagner, B. Schaub, F. Meya, L. Fladt, J. Dittrich, T. Fisch, U. Macha, K. Haupenthal, D. Gassmann, L. Wang, R. Stoll, S. Schwab, S. Volbers, B. Siedler, G. Kallmünzer, B. Cappellari, M. Bonetti, B. Bovi, P. Tomelleri, G. Micheletti, N. Zivelonghi, C. Emiliani, A. Parry-Jones, A. Patterson, C. Price, C. Elmarimi, A. Parry, A. Nallasivam, A. Nor, A.M. Esis, B. Bruce, D. Bhaskaran, B. Roffe, C. Cullen, C. Holmes, C. Cohen, D. Hargroves, D. Mangion, D. Chadha, D. Vahidassr, D. Manawadu, D. Giallombardo, E. Warburton, E. Flossman, E. Gunathilagan, G. Proschel, H. Emsley, H. Anwar, I. Burger, I. Okwera, J. Putterill, J. O’Connell, J. Bamford, J. Corrigan, J. Scott, J. Birns, J. Kee, K. Saastamoinen, K. Pasco, K. Dani, K. Sekaran, L. Choy, L. Iveson, L. Mamun, M. Sajid, M. Cooper, M. Burn, M. Smith, M. Power, M. Davis, M. Smyth, N. Veltkamp, R. Sharma, P. Guyler, P. O’Mahony, P. Wilkinson, P. Datta, P. Aghoram, P. Marsh, R. Luder, R. Meenakishundaram, S. Subramonian, S. Leach, S. Ispoglou, S. Andole, S. England, T. Manoj, A. Harrington, F. Rehman, H. Sword, J. Staals, J. Mahawish, K. Harkness, K. Shaw, L. McCormich, M. Sprigg, N. Mansoor, S. Krishnamurthy, V. Giustozzi, M. Acciarresi, M. Agnelli, G. Becattini, C. Alberti, A. D’Amore, C. Cimini, L.A. Bandini, F. Tsivgoulis, G. Liantinioti, C. Chondrogianni, M. Yaghi, S. Furie, K.L. Tadi, P. Zedde, M. Abdul-Rahim, A.H. Lees, K.R. Bovi, P. Carletti, M. Rigatelli, A. Cappellari, M. Putaala, J. Tomppo, L. Tatlisumak, T. Marcheselli, S. Pezzini, A. Poli, L. Padovani, A. Vannucchi, V. Masotti, L. Sohn, S.-I. Lorenzini, G. Tassi, R. Guideri, F. Acampa, M. Martini, G. Ntaios, G. Athanasakis, G. Makaritsis, K. Karagkiozi, E. Vadikolias, K. Mumoli, N. Galati, F. Sacco, S. Tiseo, C. Corea, F. Ageno, W. Bellesini, M. Colombo, G. Silvestrelli, G. Ciccone, A. Lanari, A. Scoditti, U. Denti, L. Mancuso, M. Maccarrone, M. Ulivi, L. Orlandi, G. Giannini, N. Tassinari, T. De Lodovici, M.L. Rueckert, C. Baldi, A. Toni, D. Letteri, F. Pieroni, A. Giuntini, M. Lotti, E.M. Flomin, Y. Kargiotis, O. Karapanayiotides, T. Monaco, S. Baronello, M.M. Csiba, L. Szabó, L. Chiti, A. Giorli, E. Del Sette, M. Imberti, D. Zabzuni, D. Doronin, B. Volodina, V. Michel, P. Vanacker, P. Barlinn, K. Pallesen, L.-P. Barlinn, J. Deleu, D. Melikyan, G. Ibrahim, F. Akhtar, N. Gourbali, V. Todo, K. Kimura, K. Shibazaki, K. Yagita, Y. Furui, E. Itabashi, R. Terasaki, T. Shiokawa, Y. Hirano, T. Suzuki, R. Kamiyama, K. Nakagawara, J. Takizawa, S. Homma, K. Okuda, S. Okada, Y. Maeda, K. Kameda, T. Kario, K. Nagakane, Y. Hasegawa, Y. Akiyama, H. Shibuya, S. Mochizuki, H. Ito, Y. Nakashima, T. Matsuoka, H. Takamatsu, K. Nishiyama, K. Tanaka, K. Endo, K. Miyagi, T. Osaki, M. Kobayashi, J. Okata, T. Tanaka, E. Sakamoto, Y. Tokunaga, K. Takizawa, H. Takasugi, J. Matsubara, S. Higashida, K. Matsuki, T. Kinoshita, N. Shiozawa, M. Ide, T. Yoshimoto, T. Ando, D. Fujita, K. Kumamoto, M. Kamimura, T. Kikuno, M. Mizoguchi, T. Sato, T. NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF Verona Registry Collaborators

Abstract

Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (

Published
2022

56. Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease (Translational Neurodegeneration, (2022), 11, 1, (37), 10.1186/s40035-022-00311-3)

Author

Bongianni, M., Catalan, M., Perra, D., Fontana, E., Janes, F., Bertolotti, C., Sacchetto, L., Capaldi, S., Tagliapietra, M., Polverino, P., Tommasini, V., Bellavita, G., Kachoie, E. A., Baruca, R., Bernardini, A., Valente, M., Fiorini, M., Bronzato, E., Tamburin, S., Bertolasi, L., Brozzetti, L., Cecchini, M. P., Gigli, G., Monaco, S., Manganotti, P., and Zanusso, G.

Published
2022

57. Economia e Ingegneria. Dinamiche comparate

Author

Acocella, N., Alippi, A., Allocca, N., Annesini, M. C., Calabrese, M., Carboni, B., Caricchi, F., Carillo, S., Frezza, F., Gallo, R., Lacarbonara, W., Monaco, S., Napolitano, F., Ridolfi, E., and Verdone, N.

Subjects
economia, ingegneria, modelli
Published
2022

59. An Italian multicenter retrospective-prospective observational study on neurological manifestations of COVID-19 (NEUROCOVID)

Author

Ferrarese, C, Silani, V, Priori, A, Galimberti, S, Agostoni, E, Monaco, S, Padovani, A, Tedeschi, G, Ferrarese C., Silani V., Priori A., Galimberti S., Agostoni E., Monaco S., Padovani A., Tedeschi G., Ferrarese, C, Silani, V, Priori, A, Galimberti, S, Agostoni, E, Monaco, S, Padovani, A, Tedeschi, G, Ferrarese C., Silani V., Priori A., Galimberti S., Agostoni E., Monaco S., Padovani A., and Tedeschi G.

Abstract

Neurological manifestations of COVID-19 have been described in both single case reports and retrospective scanty case series. They may be linked to the potential neurotropism of the SARS-COV-2 virus, as previously demonstrated for other coronaviruses. We report here the description of a multicenter retrospective-prospective observational study promoted by the Italian Society of Neurology (SIN), involving the Italian Neurological Departments, who will consecutively recruit patients with neurological symptoms and/or signs, occurred at the onset or as a complication of COVID-19. Hospitalized patients will be recruited either in neurological wards or in COVID wards; in the latter cases, they will be referred from other specialists to participant neurologists. Outpatients with clinical signs of COVID and neurological manifestations will be also referred to participating neurologists from primary care physicians. A comprehensive data collection, in the form of electronic case report form (eCRF), will register all possible neurological manifestations involving central nervous systems, peripheral nerves, and muscles, together with clinical, laboratory (including cerebrospinal fluid, if available), imaging, neurological, neurophysiological, and neuropsychological data. A follow-up at hospital discharge (in hospitalized patients), and for all patients after 3 and 6 months, is also planned. We believe that this study may help to intercept the full spectrum of neurological manifestations of COVID-19 and, given the large diffusion at national level, can provide a large cohort of patients available for future more focused investigations. Similar observational studies might also be proposed at international level to better define the neurological involvement of COVID-19.

Published
2020

60. Emotional facial expressions affect visual rule learning in 7- to 8-month-old infants

Author

Quadrelli, E, Brenna, V, Monaco, S, Turati, C, Bulf, H, Quadrelli E., Brenna V., Monaco S., Turati C., Bulf H., Quadrelli, E, Brenna, V, Monaco, S, Turati, C, Bulf, H, Quadrelli E., Brenna V., Monaco S., Turati C., and Bulf H.

Abstract

Rule learning (RL) is an implicit learning mechanism that allows infants to detect and generalize rule-like repetition-based patterns (such as ABB and ABA) from a sequence of elements. Increasing evidence shows that RL operates both in the auditory and the visual domain and is modulated by the perceptual expertise with the to-be-learned stimuli. Yet, whether infants’ ability to detect a high-order rule from a sequence of stimuli is affected by affective information remains a largely unexplored issue. Using a visual habituation paradigm, we investigated whether the presence of emotional expressions with a positive and a negative value (i.e., happiness and anger) modulates 7- to 8-month-old infants’ ability to learn a rule-like pattern from a sequence of faces of different identities. Results demonstrate that emotional facial expressions (either positive and negative) modulate infants’ visual RL mechanism, even though positive and negative facial expressions affect infants’ RL in a different manner: while anger disrupts infants’ ability to learn the rule-like pattern from a face sequence, in the presence of a happy face infants show a familiarity preference, thus maintaining their learning ability. These findings show that emotional expressions exert an influence on infants’ RL abilities, contributing to the investigation on how emotion and cognition interact in face processing during infancy.

Published
2020

62. Canonical Representations of Nonlinear Discrete-time Systems

Author

Monaco, S., Normand-Cyrot, D., Byrnes, Christopher I., editor, Amari, S.-I., editor, Anderson, B. D. O., editor, Åström, Karl Johan, editor, Aubin, Jean-Pierre, editor, Banks, H. T., editor, Baras, John S., editor, Bensoussan, A., editor, Burns, John, editor, Chen, Han-Fu, editor, Davis, M. H. A., editor, Fleming, Wendell, editor, Fliess, Michel, editor, Glover, Keith, editor, Hinrichsen, Diederich, editor, Isidori, Alberto, editor, Jakubczyk, B., editor, Kimura, Hidenori, editor, Krener, Arthur J., editor, Kunita, H., editor, Kurzhansky, Alexandre, editor, Kushner, Harold J., editor, Lindquist, Anders, editor, Manitius, Andrzej, editor, Martin, Clyde F., editor, Mitter, Sanjoy, editor, Picci, Giorgio, editor, Pshenichnyj, Boris, editor, Sussmann, H. J., editor, Tarn, Tzyh-Jong, editor, Tikhomirov, V. M., editor, Varaiya, Pravin P., editor, Willems, Jan C., editor, Wonham, W. M., editor, and Isidori, Albert, editor

Published
1992
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63. Ruminococcus gnavus ATC29149 endo-beta-1,4-galactosidase (RgGH98)

Author

Owen, C.D., primary, Wu, H., additional, Crost, E.H., additional, van Bakel, W., additional, Gascuena, A.M., additional, Latousakis, D., additional, Hicks, T., additional, Walpole, S., additional, Urbanowicz, P.A., additional, Ndeh, D., additional, Monaco, S., additional, Salom, L.S., additional, Griffiths, R., additional, Colvile, A., additional, Spencer, D.I.R., additional, Walsh, M.A., additional, Angulo, J., additional, and Juge, N., additional

Published
2022
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65. Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry

Author

Pappaccogli, M, Prejbisz, A, Ciurică, S, Bruno, Rm, Aniszczuk-Hybiak, A, Bracalente, I, De Backer, T, Debiève, F, Delmotte, P, Di Monaco, S, Jarraya, F, Gordin, D, Kosiński, P, Kroon, Aa, Maas, Ahem, Marcon, D, Minuz, P, Montagud-Marrahi, E, Pasquet, A, Poch, E, Rabbia, F, Stergiou, Gs, Tikkanen, I, Toubiana, L, Vinck, W, Warchoł-Celińska, E, Van der Niepen, P, de Leeuw, P, Januszewicz, A, Persu, A, European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) and the Working Group 'Hypertension and the Kidney' of the ESH: Alexandre Persu, Marco, Pappaccogli, Christophe, Beauloye, Patrick, Chenu, Jean-Philippe, Lengelé, Frank, Hammer, Pierre, Goffette, Parla, Astarci, André, Peeters, Robert, Verhelst, Miikka, Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie, Gevaert, Philippe, Delmotte, Wouter, Vinck, Daniel, T Gordin, Ilkka, Tikkanen, Maarit, Venermo, George, S Stergiou, Rosa Maria Bruno, Stefano, Taddei, Caterina, Romanini, Ilaria, Petrucci, Franco, Rabbia, Silvia Di Monaco, Pietro, Minuz, Mansueto, Giancarlo, DE MARCHI, Sergio, Denise, Marcon, Bram, Kroon, Peter de Leeuw, Andrzej, Januszewicz, Ewa, Warchol-Celinska, Aleksander, Prejbisz, Adam, Witkowski, Helena, Witowicz, Anna, Aniszczuk-Hybiak, Krzysztof, Pieluszczak, Magdalena, Januszewicz, Piotr, Dobrowolski, Esteban, Poch, Enrique, Montagud-Marrahi, Alicia, Molina, Elena, Guillen, Marta, Burrel, Hanen, Chaker, Faiçal, Jarraya, Anita, Mäkelä, Katarzyna, Józwik-Plebanek, Elżbieta, Florczak, Jacek, Kądziela, Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Interne Geneeskunde, MUMC+: MA Alg Interne Geneeskunde (9), and RS: Carim - V02 Hypertension and target organ damage

Subjects
Gestational hypertension, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], fibromuscular dysplasia, Comorbidity, Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Aneurysm rupture, pregnancy-induced, Renal Artery, 0302 clinical medicine, Registries, CARDIOLOGY, OUTCOMES, 030219 obstetrics & reproductive medicine, Obstetrics, WOMEN, Middle Aged, EUROPEAN-SOCIETY, follow-up studies, 3. Good health, PREVALENCE, hypertension, pregnancy-induced, preeclampsia, pregnancy, Lower prevalence, cardiovascular system, Premature Birth, Female, Adult, medicine.medical_specialty, hypertension, Revascularization, DIAGNOSIS, CLASSIFICATION, Preeclampsia, Young Adult, 03 medical and health sciences, ANEURYSM, Internal Medicine, medicine, CORONARY-ARTERY DISSECTION, MANAGEMENT, Humans, In patient, cardiovascular diseases, Pregnancy, business.industry, medicine.disease, Pregnancy Complications, RISK-FACTORS, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business
Abstract

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P P =0.003) but underwent more often renal revascularization (63% versus 40%, P

Published
2020

70. The European/international fibromuscular dysplasia registry and initiative (FEIRI) - Clinical phenotypes and their predictors based on a cohort of 1000 patients

Author

Pappaccogli, M, Di Monaco, S, Warchoł-Celińska, E, Lorthioir, A, Amar, L, Aparicio, Ls, Beauloye, C, Bruno, Rm, Chenu, P, de Leeuw, P, De Backer, T, Delmotte, P, Dika, Z, Gordin, D, Heuten, H, Iwashima, Y, Krzesinski, Jm, Kroon, Aa, Mazzolai, L, Poch, E, Sarafidis, P, Seinturier, C, Spiering, W, Toubiana, L, Van der Niepen, P, van Twist, D, Visonà, A, Wautrecht, Jc, Witowicz, H, Xu, J, Prejbisz, A, Januszewicz, A, Azizi, M, Persu, A, European/International FMD Registry and Initiative (FEIRI), and the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) Collaborators: Lucas, S Aparicio, Alexandre, Persu, Marco, Pappaccogli, Christophe, Beauloye, Patrick, Chenu, Frank, Hammer, Pierre, Goffette, Parla, Astarci, André, Peeters, Robert, Verhelst, Miikka, Vikkula, Patricia Van der Niepen, Frank Van Tussenbroek, Tine De Backer, Sofie, Gevaert, Dimitri, Hemelsoet, Luc, Defreyne, Hilde, Heuten, Laetitia, Yperzeele, Thijs Van der Zijden, Jean-Philippe, Lengelé, Jean-Marie, Krzesinski, Muriel, Sprynger, Philippe, Delmotte, Peter, Verhamme, Thomas, Vanassche, Pasquale, Scoppettuolo, Jean-Claude, Wautrecht, Wouter, Vinck, Vassilev, Dobrin, Yaneva, Teodora, Jiguang, Wang, Jianzhong, Xu, Bojan, Jelaković, Zivka, Dika, Daniel, Gordin, Ilkka, Tikkanen, Maarit, Venermo, N Mäkelä, R, Pierre-François, Plouin, Xavier, Jeunemaitre, Laurent, Toubiana, Michel, Azizi, Laurence, Amar, Antoine, Chédid, Elie, Mousseaux, Aurélien, Lorthioir, Olivier, Ormezzano, Christopher, Seinturier, Frédéric, Thony, Felix, Mahfoud, Saarraaken, Kulenthiran, Pantelis, Sarafidis, Alexia, Piperidou, Michael, Doumas, George, S Stergiou, Demetrios, Vlahakos, Caitriona, Canning, Yehonatan, Sharabi, Alberto, Morganti, Rosa Maria Bruno, Stefano, Taddei, Caterina, Romanini, Ilaria, Petrucci, Franco, Rabbia, Silvia Di Monaco, Gian Paolo Rossi, Silvia, Lerco, Minuz, Pietro, Mansueto, Giancarlo, DE MARCHI, Sergio, Marcon, Denise, Patrizia, Salice, Adriana, Visonà, Paola, Bigolin, Viviana, Zingaretti, Rosario, Cianci, Marialuisa, Zedde, Maria Chiara Matteucci, Yoshio, Iwashima, Osami, Kawarada, Yoshito, Kadoya, Daan, J van Twist, Bram, Kroon, Peter de Leeuw, Wilko, Spiering, Bert-Jan van den Born, Aud, Høieggen, Martin Skage Sommer, Andrzej, Januszewicz, Ewa, Warchoł-Celińska, Aleksander, Prejbisz, Adam, Witkowski, Helena, Witowicz, Jacek, Kądziela, Aleksandra, Soplińska, Krzysztof, Pieluszczak, Katarzyna, Jóżwik-Plebanek, Magdalena, Januszewicz, Elżbieta, Florczak, Piotr, Dobrowolski, Eva, Szabóová, Marek, Hudák, Matej, Moščovič, Juan Diego Mediavilla, Fernando Jaen Aguila, Anna, Oliveras, Julian, Segura, Jose, C Prado, Nicolas Roberto Robles, Esteban, Poch, Enrique, Montagud-Marrahi, Alicia, Molina, Elena, Guillen, Marta, Burrel, Patricia Fernàndez De la Llama, Antonio, J Barros-Membrilla, Anders, Gottsäter, Gregor, Wuerzner, Lucia, Mazzolai, Giacomo, Buso, Faiçal, Jarraya, Hanen, Chaker, David, Adlam, Constantina, Chrysochou, Neeraj, Dhaun, Robert, W Hunter, Iain, Macintyre, David, Webb, Public and occupational health, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, APH - Personalized Medicine, APH - Global Health, ACS - Heart failure & arrhythmias, Interne Geneeskunde, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: Carim - V02 Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/DDUV/GEHU - Génétique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de neurologie, and UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique

Subjects
Male, renovascular hypertension, Computed Tomography Angiography, Physiology, [SDV]Life Sciences [q-bio], Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Magnetic resonance angiography, 0302 clinical medicine, Risk Factors, Prevalence, Registries, Renovascular hypertension, Stroke, Computed tomography angiography, medicine.diagnostic_test, fibromuscular dysplasia, dissection, aneurysm, stroke, Incidence, Dissection, Age Factors, Middle Aged, Prognosis, 3. Good health, Europe, Phenotype, Cohort, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, circulatory and respiratory physiology, Adult, medicine.medical_specialty, Asia, Tunisia, Aneurysm, Argentina, Risk Assessment, 03 medical and health sciences, Sex Factors, stomatognathic system, Predictive Value of Tests, Physiology (medical), Internal medicine, medicine, Humans, cardiovascular diseases, Aged, business.industry, medicine.disease, Aortic Dissection, Stenosis, Angiography, business, Magnetic Resonance Angiography, 030217 neurology & neurosurgery
Abstract

AIMS: Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. METHODS AND RESULTS: All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on CTA, MRA and/or catheter-based angiography were eligible.Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46±16 years (12% ≥65yo), 86% were hypertensive, 72% had multifocal and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65yo had more often multifocal FMD, lower eGFR and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke and multivessel FMD. CONCLUSIONS: The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management and follow-up of FMD. TRANSLATIONAL PERSPECTIVE: Fibromuscular dysplasia (FMD) is nowadays considered as a systemic arterial disease, warranting brain-to-pelvis vascular imaging in all patients. However, most current evidence is derived from a limited number of expert centres. Furthermore, one size may not fit all. Based on analysis of the first thousand patients enrolled in the European/International FMD registry (46 centres; 22 countries) we characterized distinct patient profiles according to FMD subtype, age and gender and identified predictors of widespread disease, aneurysms and dissections, paving the way for individualized management and follow-up. Further studies will allow refining patient characterization according to ethnicity, genetic profile and imaging biomarkers.

Published
2021
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72. Clinical and neurophysiological serial assessments of brentuximab vedotin-associated peripheral neuropathy

Author

Mariotto, S, Tecchio, C, Sorio, M, Bertolasi, L, Turatti, M, Tozzi, M, Benedetti, F, Cavaletti, G, Monaco, S, Ferrari, S, Mariotto S., Tecchio C., Sorio M., Bertolasi L., Turatti M., Tozzi M. C., Benedetti F., Cavaletti G., Monaco S., Ferrari S., Mariotto, S, Tecchio, C, Sorio, M, Bertolasi, L, Turatti, M, Tozzi, M, Benedetti, F, Cavaletti, G, Monaco, S, Ferrari, S, Mariotto S., Tecchio C., Sorio M., Bertolasi L., Turatti M., Tozzi M. C., Benedetti F., Cavaletti G., Monaco S., and Ferrari S.

Published
2019

73. Risk Factors for Intracerebral Hemorrhage in Patients with Atrial Fibrillation on Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

Author

Paciaroni, M. Agnelli, G. Giustozzi, M. Caso, V. Toso, E. Angelini, F. Canavero, I. Micieli, G. Antonenko, K. Rocco, A. Diomedi, M. Katsanos, A.H. Shoamanesh, A. Giannopoulos, S. Ageno, W. Pegoraro, S. Putaala, J. Strbian, D. Sallinen, H. Mac Grory, B.C. Furie, K.L. Stretz, C. Reznik, M.E. Alberti, A. Venti, M. Mosconi, M.G. Vedovati, M.C. Franco, L. Zepponi, G. Romoli, M. Zini, A. Brancaleoni, L. Riva, L. Silvestrelli, G. Ciccone, A. Zedde, M.L. Giorli, E. Kosmidou, M. Ntais, E. Palaiodimou, L. Halvatsiotis, P. Tassinari, T. Saia, V. Ornello, R. Sacco, S. Bandini, F. Mancuso, M. Orlandi, G. Ferrari, E. Pezzini, A. Poli, L. Cappellari, M. Forlivesi, S. Rigatelli, A. Yaghi, S. Scher, E. Frontera, J.A. Masotti, L. Grifoni, E. Caliandro, P. Zauli, A. Reale, G. Marcheselli, S. Gasparro, A. Terruso, V. Arnao, V. Aridon, P. Abdul-Rahim, A.H. Dawson, J. Saggese, C.E. Palmerini, F. Doronin, B. Volodina, V. Toni, D. Risitano, A. Schirinzi, E. Del Sette, M. Lochner, P. Monaco, S. Mannino, M. Tassi, R. Guideri, F. Acampa, M. Martini, G. Lotti, E.M. Padroni, M. Pantoni, L. Rosa, S. Bertora, P. Ntaios, G. Sagris, D. Baldi, A. D'Amore, C. Mumoli, N. Porta, C. Denti, L. Chiti, A. Corea, F. Acciarresi, M. Flomin, Y. Popovic, N. Tsivgoulis, G.

Subjects
cardiovascular diseases
Abstract

Background and Purpose: Clinical trials on stroke prevention in patients with atrial fibrillation have consistently shown clinical benefit from either warfarin or non-vitamin K antagonist oral anticoagulants (NOACs). NOAC-treated patients have consistently reported to be at lower risk for intracerebral hemorrhage (ICH) than warfarin-treated patients. The aims of this prospective, multicenter, multinational, unmatched, case-control study were (1) to investigate for risk factors that could predict ICH occurring in patients with atrial fibrillation during NOAC treatment and (2) to evaluate the role of CHA2DS2-VASc and HAS-BLED scores in the same setting. Methods: Cases were consecutive patients with atrial fibrillation who had ICH during NOAC treatment. Controls were consecutive patients with atrial fibrillation who did not have ICH during NOAC treatment. As within the CHA2DS2-VASc and HAS-BLED scores there are some risk factors in common, several multivariable logistic regression models were performed to identify independent prespecified predictors for ICH events. Results: Four hundred nineteen cases (mean age, 78.8±8.1 years) and 1526 controls (mean age, 76.0±10.3 years) were included in the study. From the different models performed, independent predictors of ICH were increasing age, concomitant use of antiplatelet agents, active malignancy, high risk of fall, hyperlipidemia, low clearance of creatinine, peripheral artery disease, and white matter changes. Low doses of NOACs (given according to label or not) and congestive heart failure were inversely associated with the risk of ICH. HAS-BLED and CHA2DS2-VASc scores performed poorly in predicting ICH with areas under the curves of 0.496 (95% CI, 0.468-0.525) and 0.530 (95% CI, 0.500-0.560), respectively. Conclusions: Several risk factors were associated to ICH in patients treated with NOACs for stroke prevention but not HAS-BLED and CHA2DS2-VASc scores. © 2021 Lippincott Williams and Wilkins. All rights reserved.

Published
2021

75. The European/international fibromuscular dysplasia registry and initiative (FEIRI) - Clinical phenotypes and their predictors based on a cohort of 1000 patients

Author

Pappaccogli, M. Di Monaco, S. Warchoł-Celińska, E. Lorthioir, A. Amar, L. Aparicio, L.S. Beauloye, C. Bruno, R.M. Chenu, P. De Leeuw, P. De Backer, T. Delmotte, P. Dika, Z. Gordin, D. Heuten, H. Iwashima, Y. Krzesinski, J.-M. Kroon, A.A. Mazzolai, L. Poch, E. Sarafidis, P. Seinturier, C. Spiering, W. Toubiana, L. Van Der Niepen, P. Van Twist, D. Visonà, A. Wautrecht, J.-C. Witowicz, H. Xu, J. Prejbisz, A. Januszewicz, A. Azizi, M. Persu, A. Hammer, F. Goffette, P. Astarci, P. Peeters, A. Verhelst, R. Vikkula, M. Van Tussenbroek, F. Gevaert, S. Hemelsoet, D. Defreyne, L. Yperzeele, L. Van Der Zijden, T. Lengelé, J.-P. Sprynger, M. Verhamme, P. Vanassche, T. Scoppettuolo, P. Vinck, W. Dobrin, V. Teodora, Y. Wang, J. Jelaković, B. Tikkanen, I. Venermo, M. Mäkelä, A. Plouin, P.-F. Jeunemaitre, X. Chédid, A. Mousseaux, E. Touzé, E. Ormezzano, O. Seinturier, C. Thony, F. Mahfoud, F. Kulenthiran, S. Piperidou, A. Doumas, M. Stergiou, G.S. Vlahakos, D. Canning, C. Sharabi, Y. Morganti, A. Taddei, S. Romanini, C. Petrucci, I. Rabbia, F. Rossi, G.P. Lerco, S. Minuz, P. Mansueto, G. De Marchi, S. Marcon, D. Salice, P. Bigolin, P. Zingaretti, V. Cianci, R. Zedde, M. Matteucci, M.C. Kawarada, O. Kadoya, Y. Van Twist, D.J. Kroon, B. Van Den Born, B.-J. Høieggen, A. Sommer, M.S. Witkowski, A. Kądziela, J. Soplińska, A. Pieluszczak, K. Józwik-Plebanek, K. Januszewicz, M. Florczak, E. Dobrowolski, P. Szabóová, E. Hudák, M. Moščovič, M. Mediavilla, J.D. Aguila, F.J. Oliveras, A. Segura, J. Prado, J.C. Robles, N.R. Montagud-Marrahi, E. Molina, A. Guillen, E. Burrel, M. De La Llama, P.F. Miguel-Amigo, L.S. Barros-Membrilla, A.J. Gottsäter, A. Wuerzner, G. Buso, G. Jarraya, F. Chaker, H. Adlam, D. Chrysochou, C. Dhaun, N. Hunter, R.W. MacIntyre, I. Webb, D. European/International FMD Registry Initiative (FEIRI) Working Group 'Hypertension the Kidney' of the European Society of Hypertension (ESH) and Pappaccogli, M. Di Monaco, S. Warchoł-Celińska, E. Lorthioir, A. Amar, L. Aparicio, L.S. Beauloye, C. Bruno, R.M. Chenu, P. De Leeuw, P. De Backer, T. Delmotte, P. Dika, Z. Gordin, D. Heuten, H. Iwashima, Y. Krzesinski, J.-M. Kroon, A.A. Mazzolai, L. Poch, E. Sarafidis, P. Seinturier, C. Spiering, W. Toubiana, L. Van Der Niepen, P. Van Twist, D. Visonà, A. Wautrecht, J.-C. Witowicz, H. Xu, J. Prejbisz, A. Januszewicz, A. Azizi, M. Persu, A. Hammer, F. Goffette, P. Astarci, P. Peeters, A. Verhelst, R. Vikkula, M. Van Tussenbroek, F. Gevaert, S. Hemelsoet, D. Defreyne, L. Yperzeele, L. Van Der Zijden, T. Lengelé, J.-P. Sprynger, M. Verhamme, P. Vanassche, T. Scoppettuolo, P. Vinck, W. Dobrin, V. Teodora, Y. Wang, J. Jelaković, B. Tikkanen, I. Venermo, M. Mäkelä, A. Plouin, P.-F. Jeunemaitre, X. Chédid, A. Mousseaux, E. Touzé, E. Ormezzano, O. Seinturier, C. Thony, F. Mahfoud, F. Kulenthiran, S. Piperidou, A. Doumas, M. Stergiou, G.S. Vlahakos, D. Canning, C. Sharabi, Y. Morganti, A. Taddei, S. Romanini, C. Petrucci, I. Rabbia, F. Rossi, G.P. Lerco, S. Minuz, P. Mansueto, G. De Marchi, S. Marcon, D. Salice, P. Bigolin, P. Zingaretti, V. Cianci, R. Zedde, M. Matteucci, M.C. Kawarada, O. Kadoya, Y. Van Twist, D.J. Kroon, B. Van Den Born, B.-J. Høieggen, A. Sommer, M.S. Witkowski, A. Kądziela, J. Soplińska, A. Pieluszczak, K. Józwik-Plebanek, K. Januszewicz, M. Florczak, E. Dobrowolski, P. Szabóová, E. Hudák, M. Moščovič, M. Mediavilla, J.D. Aguila, F.J. Oliveras, A. Segura, J. Prado, J.C. Robles, N.R. Montagud-Marrahi, E. Molina, A. Guillen, E. Burrel, M. De La Llama, P.F. Miguel-Amigo, L.S. Barros-Membrilla, A.J. Gottsäter, A. Wuerzner, G. Buso, G. Jarraya, F. Chaker, H. Adlam, D. Chrysochou, C. Dhaun, N. Hunter, R.W. MacIntyre, I. Webb, D. European/International FMD Registry Initiative (FEIRI) Working Group 'Hypertension the Kidney' of the European Society of Hypertension (ESH)

Abstract

Aims: Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. Methods and results: All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12% ≥65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients ≥65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD. Conclusions: The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD. © 2020 Published on behalf of the European Society of Cardiology. All rights reserved.

Published
2021

76. The European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)-clinical phenotypes and their predictors based on a cohort of 1000 patients

Author

Pappaccogli, M., Pappaccogli, M., Di Monaco, S., Warchol-Celinska, E., Lorthioir, A., Amar, L., Aparicio, L.S., Beauloye, C., Bruno, R.M., Chenu, P., de Leeuw, P., De Backer, T., Delmotte, P., Dika, Z., Gordin, D., Heuten, H., Iwashima, Y., Krzesinski, J.M., Kroon, A.A., Mazzolai, L., Poch, E., Sarafidis, P., Seinturier, C., Spiering, W., Toubiana, L., Van der Niepen, P., van Twist, D., Visona, A., Wautrecht, J.C., Witowicz, H., Xu, J.Z., Prejbisz, A., Januszewicz, A., Azizi, M., Persu, A., European/International FMD Registry and Initiative (FEIRI), Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH), Pappaccogli, M., Pappaccogli, M., Di Monaco, S., Warchol-Celinska, E., Lorthioir, A., Amar, L., Aparicio, L.S., Beauloye, C., Bruno, R.M., Chenu, P., de Leeuw, P., De Backer, T., Delmotte, P., Dika, Z., Gordin, D., Heuten, H., Iwashima, Y., Krzesinski, J.M., Kroon, A.A., Mazzolai, L., Poch, E., Sarafidis, P., Seinturier, C., Spiering, W., Toubiana, L., Van der Niepen, P., van Twist, D., Visona, A., Wautrecht, J.C., Witowicz, H., Xu, J.Z., Prejbisz, A., Januszewicz, A., Azizi, M., Persu, A., European/International FMD Registry and Initiative (FEIRI), and Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH)

Abstract

Aims Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections.Methods and results All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 +/- 16 years (12% >= 65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients >= 65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD.Conclusions The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD.

Published
2021

77. Improving the Sexual Health of Young People (under 25) in High-Risk Populations: A Systematic Review of Behavioural and Psychosocial Interventions

Author

Brown, E, Lo Monaco, S, O'Donoghue, B, Nolan, H, Hughes, E, Graham, M, Simmons, M, Gray, R, Brown, E, Lo Monaco, S, O'Donoghue, B, Nolan, H, Hughes, E, Graham, M, Simmons, M, and Gray, R

Abstract

Background: Ensuring young people experience good sexual health is a key public health concern, yet some vulnerable groups of young people remain at higher risk of poor sexual health. These individuals require additional support to achieve good sexual health but the best way to provide this remains needs to be better understood. Methods: We searched for randomised controlled trials of behavioural and psychosocial interventions aimed at promoting sexual health in high-risk young populations. Outcomes of interest were indicators of sexual health (e.g., condom use, attitudes to contraception, knowledge of risk). Participants were under 25 years old and in one of the following high-risk groups: alcohol and other drug use; ethnic minority; homeless; justice-involved; LGBTQI+; mental ill-health; or out-of-home care. Results: Twenty-eight papers from 26 trials met our inclusion criteria, with all but one conducted in North America. Condom use was the most frequently reported outcome measure along with knowledge and attitudes towards sexual health but considerable differences in measures used made comparisons across studies difficult. Change in knowledge and attitudes did not consistently result in long-term change in behaviours. Conclusions: There remains a dearth of research undertaken outside of North America across all high-risk groups of young people. Future interventions should address sexual health more broadly than just the absence of negative biological outcomes, with LGBTQI+, homeless and mental ill-health populations targeted for such work. An international consensus on outcome measures would support the research field going forward, making future meta-analyses possible.

Published
2021

87. Discrete-time approximated linearization of SISO systems under output feedback

Author

Barbot, J.P., Monaco, S., and Normand-Cyrot, D.

Subjects
Discrete-time systems -- Design and construction, Dynamic programming -- Usage, Feedback control systems -- Design and construction, Nonlinear programming -- Usage, Quadratic programming -- Usage
Abstract

This paper deals with higher order approximation for discrete-time systems. It is shown that approximated feedback linearization at the second order can always be achieved under feedback compensation based on an approximated observer. An example is given in order to illustrate the control design and the efficiency of the proposed method. Index Terms - Dynamic state feedback, nonlinear discrete-time systems, nonlinear observer, quadratic approximation.

Published
1999

92. Safety of Anticoagulation in Patients Treated with Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation

Author

Giustozzi, M. Acciarresi, M. Agnelli, G. Caso, V. Bandini, F. Tsivgoulis, G. Yaghi, S. Furie, K.L. Tadi, P. Becattini, C. Zedde, M. Abdul-Rahim, A.H. Lees, K.R. Alberti, A. Venti, M. D'Amore, C. Giulia Mosconi, M. Anna Cimini, L. Bovi, P. Carletti, M. Rigatelli, A. Cappellari, M. Putaala, J. Tomppo, L. Tatlisumak, T. Marcheselli, S. Pezzini, A. Poli, L. Padovani, A. Vannucchi, V. Sohn, S.-I. Lorenzini, G. Tassi, R. Guideri, F. Acampa, M. Martini, G. Ntaios, G. Athanasakis, G. Makaritsis, K. Karagkiozi, E. Vadikolias, K. Liantinioti, C. Theodorou, A. Halvatsiotis, P. Mumoli, N. Galati, F. Sacco, S. Tiseo, C. Corea, F. Ageno, W. Bellesini, M. Silvestrelli, G. Ciccone, A. Lanari, A. Scoditti, U. Denti, L. Mancuso, M. Ferrari, E. Ulivi, L. Orlandi, G. Giannini, N. Tassinari, T. Luisa De Lodovici, M. Rueckert, C. Baldi, A. Toni, D. Letteri, F. Giuntini, M. Maria Lotti, E. Flomin, Y. Pieroni, A. Kargiotis, O. Karapanayiotides, T. Monaco, S. Maimone Baronello, M. Csiba, L. Szabó, L. Chiti, A. Giorli, E. Del Sette, M. Imberti, D. Zabzuni, D. Doronin, B. Volodina, V. Michel, P. Vanacker, P. Barlinn, K. Barlinn, J. Deleu, D. Gourbali, V. Paciaroni, M. Masotti, L.

Abstract

Background and Purpose: The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical thrombectomy. We aimed at assessing the incidence of early recurrence and major bleeding in patients with acute ischemic stroke and atrial fibrillation treated with thrombolytic therapy and/or thrombectomy, who then received oral anticoagulants for secondary prevention. Methods: We combined the dataset of the RAF and the RAF-NOACs (Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non-Vitamin K Oral Anticoagulants) studies, which were prospective observational studies carried out from January 2012 to March 2014 and April 2014 to June 2016, respectively. We included consecutive patients with acute ischemic stroke and atrial fibrillation treated with either Vitamin K antagonists or nonVitamin K oral anticoagulants. Primary outcome was the composite of stroke, transient ischemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding within 90 days from the inclusion. Treated-patients were propensity matched to untreated-patients in a 1:1 ratio after stratification by baseline clinical features. Results: A total of 2159 patients were included, 564 (26%) patients received acute reperfusion therapies. After the index event, 505 (90%) patients treated with acute reperfusion therapies and 1287 of 1595 (81%) patients untreated started oral anticoagulation. Timing of starting oral anticoagulant was similar in reperfusion-treated and untreated patients (median 7.5 versus 7.0 days, respectively). At 90 days, the primary study outcome occurred in 37 (7%) patients treated with reperfusion and in 146 (9%) untreated patients (odds ratio, 0.74 [95% CI, 0.50-1.07]). After propensity score matching, risk of primary outcome was comparable between the 2 groups (odds ratio, 1.06 [95% CI, 0.53-2.02]). Conclusions: Acute reperfusion treatment did not influence the risk of early recurrence and major bleeding in patients with atrial fibrillation-related acute ischemic stroke, who started on oral anticoagulant. © 2020 The Authors.

Published
2020

93. Pregnancy-related complications in patients with fibromuscular dysplasia: A report from the european/international fibromuscular dysplasia registry

Author

Pappaccogli, M. Prejbisz, A. Ciuricǎ, S. Bruno, R.M. Aniszczuk-Hybiak, A. Bracalente, I. De Backer, T. Debiève, F. Delmotte, P. Di Monaco, S. Jarraya, F. Gordin, D. Kosiński, P. Kroon, A.A. Maas, A.H.E.M. Marcon, D. Minuz, P. Montagud-Marrahi, E. Pasquet, A. Poch, E. Rabbia, F. Stergiou, G.S. Tikkanen, I. Toubiana, L. Vinck, W. Warchoł-Celińska, E. Van Der Niepen, P. De Leeuw, P. Januszewicz, A. Persu, A.

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P

Published
2020

94. Timing of initiation of oral anticoagulants in patients with acute ischemic stroke and atrial fibrillation comparing posterior and anterior circulation strokes

Author

Paciaroni, M. Agnelli, G. Giustozzi, M. Tsivgoulis, G. Yaghi, S. Grory, B.M. Furie, K.L. Tadi, P. Zedde, M. Abdul-Rahim, A.H. Dawson, J. Lees, K.R. Alberti, A. Venti, M. Acciarresi, M. D’Amore, C. Mosconi, M.G. Bogini, V. Cappellari, M. Rigatelli, A. Bonetti, B. Putaala, J. Tomppo, L. Tatlisumak, T. Bandini, F. Marcheselli, S. Pezzini, A. Poli, L. Padovani, A. Masotti, L. Grifoni, E. Vannucchi, V. Sohn, S.-I. Lorenzini, G. Tassi, R. Guideri, F. Acampa, M. Martini, G. Ntaios, G. Athanasakis, G. Makaritsis, K. Karagkiozi, E. Vadikolias, K. Liantinioti, C. Palaiodimou, L. Mumoli, N. Porta, C. Galati, F. Sacco, S. Tiseo, C. Corea, F. Ageno, W. Bellesini, M. Silvestrelli, G. Ciccone, A. Scoditti, U. Denti, L. Mancuso, M. Caselli, M.C. Maccarrone, M. Ulivi, L. Orlandi, G. Giannini, N. Tassinari, T. Lodovici, M.L.D. Rueckert, C. Baldi, A. Toni, D. Gentile, L. Letteri, F. Giuntini, M. Lotti, E.M. Flomin, Y. Pieroni, A. Kargiotis, O. Karapanayiotides, T. Monaco, S. Mannino, M. Baronello, M.M. Csiba, L. Szabó, L. Chiti, A. Giorli, E. Sette, M.D. Schirinzi, E. Imberti, D. Zabzuni, D. Doronin, B. Volodina, V. Michel, P. Eskandari, A. Vanacker, P. Barlinn, K. Barlinn, J. Deleu, D. Gourbali, V. Caso, V.

Abstract

Introduction: The aim of this study in patients with acute posterior ischaemic stroke (PS) and atrial fibrillation (AF) was to evaluate (1) the risks of recurrent ischaemic event and severe bleeding and (2) these risks in relation with oral anticoagulant therapy (OAT) and its timing. Materials and Methods: Patients with PS were prospectively included; the outcome events of these patients were compared with those of patients with anterior stroke (AS) which were taken from previous registries. The primary outcome was the composite of stroke recurrence, transient ischaemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding occurring within 90 days from acute stroke. Results: A total of 2470 patients were available for the analysis: 473 (19.1%) with PS and 1997 (80.9%) with AS. Over 90 days, 213 (8.6%) primary outcome events were recorded: 175 (8.7%) in patients with AS and 38 (8.0%) in those with PS. In patients who initiated OAT within 2 days, the primary outcome occurred in 5 out of 95 patients (5.3%) with PS compared to 21 out of 373 patients (4.3%) with AS (OR 1.07; 95% CI 0.39–2.94). In patients who initiated OAT between days 3 and 7, the primary outcome occurred in 3 out of 103 patients (2.9%) with PS compared to 26 out of 490 patients (5.3%) with AS (OR 0.54; 95% CI 0.16–1.80). Discussion: our findings suggest that, when deciding the time to initiate oral anticoagulation, the location of stroke, either anterior or posterior, does not predict the risk of outcome events. Conclusions: Patients with PS or AS and AF appear to have similar risks of ischaemic or haemorrhagic events at 90 days with no difference concerning the timing of initiation of OAT. © European Stroke Organisation 2020.

Published
2020

95. DISTINCTIVE FEATURES OF PATIENTS DIAGNOSED WITH FIBROMUSCULAR DYSPLASIA (FMD) AT AN OLDER AGE: A REPORT FROM THE EUROPEAN/INTERNATIONAL FMD REGISTRY

Author

Pappaccogli, M., Di Monaco, S., Amar, L., Aparicio, L. S., Azizi, M., Bruno, R. M., De Leeuw, P. W., Delmotte, P., Iwashima, Y., Januszewicz, A., Kroon, A. A., Poch, E., Prejbisz, A., Seinturier, C., Tikkanen, I., Toubiana, L., Van Der Niepen, P., Scoppettuolo, P., Persu, Al., Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, and Nephrology

Published
2019
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96. THE EUROPEAN/INTERNATIONAL FIBROMUSCULAR DYSPLASIA REGISTRY: MAIN FINDINGS IN THE FIRST THOUSAND PATIENTS

Author

Pappaccogli, M., Di Monaco, S., Aparicio, L. S., Azizi, M., Bruno, R. M., De Leeuw, P. W., Delmotte, P., Gordin, D., Iwashima, Y., Januszewicz, A., Kroon, A. A., Lorthioir, A., Poch, E., Prejbisz, A., Seinturier, C., Toubiana, L., Van Der Niepen, P., Wang, J., Wautrecht, J. Claude, Persu, A., Clinical sciences, Clinical Pharmacology and Clinical Pharmacy, Nephrology, and Faculty of Economic and Social Sciences and Solvay Business School

Published
2019

97. Paroxysmal non-epileptic events in the pediatric emergency department

Author

Buonsenso, Danilo, Plosnic, M., Bersani, G., Monaco, S., Ferrara, Pietro, and Chiaretti, Antonio

Subjects
Male, Bipolar Disorder, Adolescent, Children, Emergency room, Pseudoseizures, Pharmacology (medical), Diagnosis, Differential, Psychotherapy, Treatment Outcome, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Seizures, Humans, Female, Emergency Service, Hospital
Abstract

Paroxysmal non-epileptic events (PNEs), or pseudoseizures (PS) resemble epileptic seizures. They are considered part of a personality disorder and have a higher incidence among adolescents. Patients describe episodes (lasting up to 20 minutes) of loss of consciousness, twitching or jerking and unusual emotional states. Unlike epileptic seizures, they are not associated with electroencephalographic abnormalities. Distinguishing epileptic seizures from PNEs is not easy. 20% of patients with seizures have a final PNEs diagnosis but recognizing them on the first examination is difficult. Due to the severe initial clinical presentation, these patients are often admitted in the Pediatric Intensive Care Unit (PICU) and may be over-treated. We report two cases admitted to our PICU for apparent status epilepticus, in which the final diagnosis was PNEs.

Published
2019

100. On the discrete-time normal form

Author

Califano, C., Monaco, S., and Normand-Cyrot, D.

Subjects
Control theory -- Research, Discrete-time systems -- Models, Feedback control systems -- Models
Abstract

Necessary and sufficient conditions under which the discrete-time normal form exists are set both in geometric and in algebraic frameworks, leading to equivalent conditions. The results are therefore extended to generic nonlinear nonaffine continuous-time systems. Index Terms - Differential algebra, differential geometry, nonlinear discrete-time, normal form.

Published
1998

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