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138 results on '"Ubiquitins antagonists & inhibitors"'

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51. Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition.

52. Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication.

53. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells.

54. Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.

55. Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis.

56. A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.

57. The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.

58. Overactivated neddylation pathway as a therapeutic target in lung cancer.

59. Recombinant adenovirus encoding FAT10 small interfering RNA inhibits HCC growth in vitro and in vivo.

60. ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.

61. Development of inhibitors in the ubiquitination cascade.

62. Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication.

63. Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1.

64. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

65. Lack of SMALL ACIDIC PROTEIN 1 (SMAP1) causes increased sensitivity to an inhibitor of RUB/NEDD8-activating enzyme in Arabidopsis seedlings.

66. Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.

67. Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.

68. Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.

69. Ubiquitin-like protein modifiers and their potential for antiviral and anti-HCV therapy.

70. Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.

71. Negative regulation of NEDD8 conjugation pathway by novel molecules and agents for anticancer therapy.

72. Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells.

73. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.

74. MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.

75. Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis.

76. NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway.

77. Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program.

78. The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.

79. Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma.

80. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15.

81. Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents.

82. Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.

83. Ubiquitylation functions in the calcium carbonate biomineralization in the extracellular matrix.

84. The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.

85. Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.

86. Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.

87. Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.

88. The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.

89. Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.

90. Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.

91. A natural product-like inhibitor of NEDD8-activating enzyme.

92. Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer.

93. NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells.

94. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

95. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma.

96. Biochemical and cellular effects of inhibiting Nedd8 conjugation.

97. The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.

98. Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy.

99. Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein.

100. Targeting the proteasome pathway.

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