6,874 results on '"Verani A"'
Search Results
52. Acute febrile illness in Kenya: Clinical characteristics and pathogens detected among patients hospitalized with fever, 2017-2019.
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Jennifer R Verani, Eric Ng' Eno, Elizabeth A Hunsperger, Peninah Munyua, Eric Osoro, Doris Marwanga, Godfrey Bigogo, Derrick Amon, Melvin Ochieng, Paul Etau, Victor Bandika, Victor Zimbulu, John Kiogora, John Wagacha Burton, Emmanuel Okunga, Aaron M Samuels, Kariuki Njenga, Joel M Montgomery, and Marc-Alain Widdowson
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Medicine ,Science - Abstract
Acute febrile illness (AFI) is a common reason for healthcare seeking and hospitalization in Sub-Saharan Africa and is often presumed to be malaria. However, a broad range of pathogens cause fever, and more comprehensive data on AFI etiology can improve clinical management, prevent unnecessary prescriptions, and guide public health interventions. We conducted surveillance for AFI (temperature ≥38.0°C
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- 2024
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53. Modification of the temporary maximum residue levels for mepiquat in cultivated fungi and oyster mushrooms
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EFSA (European Food Safety Authority), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,cultivated fungi ,Mepiquat chloride ,MRL ,oyster mushrooms ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted a request to the competent national authority in Finland to modify the temporary maximum residue level (MRL) to a permanent MRL for the active substance mepiquat in cultivated fungi (with a specific MRL for oyster mushrooms). The data submitted in support of the request (monitoring data from food business operators) are not sufficient to derive permanent MRL proposals. The assessment of these data, complemented by an analysis of the most recent monitoring data available from EU monitoring programmes, supports the conclusion that the existing t‐MRL for cultivated fungi is still sufficient to account for the residue uptake in cultivated mushrooms other than oyster mushrooms. It was also noted that lower t‐MRLs could be derived based on the assessment of the most recent monitoring data. A risk management decision is still needed on whether to maintain the existing t‐MRL value. Regarding oyster mushrooms, EFSA derived different options for risk managers to eventually update the values of the temporary MRLs based on the most recent monitoring data from food business operators. Adequate analytical methods for enforcement are available to control the residues of mepiquat (expressed as mepiquat chloride) in the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the cross‐contamination of untreated cultivated fungi (including oyster mushrooms) from cereal straw lawfully treated with mepiquat according to the current agricultural practices is unlikely to present a risk to consumer health.
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- 2024
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54. Evaluation of confirmatory data following the Article 12 MRL review and modification of the existing maximum residue levels for aluminium phosphide and magnesium phosphide
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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aluminium phosphide ,confirmatory data ,magnesium phosphide ,MRL review ,pesticide ,risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Detia Freyberg GmbH submitted to the competent national authority in Germany two requests to evaluate the confirmatory data that were identified for tree nuts, oilseeds, cereals and commodities of animal origin in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available and two requests in accordance with Article 6 of Regulation (EC) No 396/2005 to increase the existing MRL for the active substance aluminium phosphide in peanuts, barley, oat, rye, rice and wheat, roots of herbal infusions, cocoa beans and seed spices and for the active substance magnesium phosphide in oilseeds (except peanuts) and pistachios. The four applications were combined by EFSA under the current assessment. To address the data gaps, validation data for the method of analysis for enforcement of phosphide in high‐oil content commodities and new residue trials were submitted. The data gaps on additional residue trials supporting authorisations on oilseeds and cereal grains, on clarifications regarding the discrepancies observed in the residue trial results for pistachios, and on data confirming the negligible occurrence of phosphane and its oxidation products in livestock products were considered addressed. The data gap on independent laboratory validation (ILV) and a confirmatory method for monitoring of phosphide in high‐oil content commodities was considered not fully addressed. The information provided justified a lowering of the current tentative MRLs for the whole group of cereals (except rice and ‘others’), an increase of the current tentative MRLs for pistachios, the whole group of oilseeds, rice and ‘other’ cereals, herbal infusions from roots, cocoa beans and seed spices, and a revision of the risk assessment performed for phosphane and its phosphide salts. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of AlP and Mg3P2 according to the reported agricultural practices is unlikely to present a risk to consumer health. Further risk management considerations are required.
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- 2024
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55. Modification of the existing maximum residue level for clopyralid in honey
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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clopyralid ,consumer risk assessment ,honey ,MRL ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Corteva Agriscience International Sàrl submitted a request to the competent national authority in Finland to modify the existing maximum residue levels (MRLs) for the active substance clopyralid in honey. The data submitted in support of the request were found to be sufficient to derive MRL proposals for honey. Adequate analytical methods for enforcement are available to control the residues of clopyralid (including potential conjugates) in honey at the validated limit of quantification (LOQ) of 0.001 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of clopyralid residues in honey, resulting from the authorised use of clopyralid on oilseed rape notified in the present MRL assessment, is unlikely to present a risk to consumer health.
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- 2024
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56. Modification of the existing maximum residue levels for flonicamid in various crops
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Andrea Mioč, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,Flonicamid ,MRL ,pesticide ,potatoes ,various crops ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant ISK Biosciences Europe N.V. submitted two requests to the competent national authority in Finland and Belgium, respectively, to modify the existing maximum residue levels (MRLs) for the active substance flonicamid in potatoes and in various crops. The data submitted in support of the requests were found to be sufficient to derive MRL proposals for potatoes, lettuces and salad plants, spinaches and similar leaves, beans (without pods), cardoons, celeries, Florence fennels and rhubarbs. Adequate analytical methods for enforcement are available to control the residues according to the residue definition as of the sum of flonicamid, TFNA and TFNG, expressed as flonicamid in the plant matrices under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg for each compound. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the uses of flonicamid according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2024
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57. Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study
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Lauring, Adam S, Tenforde, Mark W, Chappell, James D, Gaglani, Manjusha, Ginde, Adit A, McNeal, Tresa, Ghamande, Shekhar, Douin, David J, Talbot, H Keipp, Casey, Jonathan D, Mohr, Nicholas M, Zepeski, Anne, Shapiro, Nathan I, Gibbs, Kevin W, Files, D Clark, Hager, David N, Shehu, Arber, Prekker, Matthew E, Erickson, Heidi L, Exline, Matthew C, Gong, Michelle N, Mohamed, Amira, Johnson, Nicholas J, Srinivasan, Vasisht, Steingrub, Jay S, Peltan, Ithan D, Brown, Samuel M, Martin, Emily T, Monto, Arnold S, Khan, Akram, Hough, Catherine L, Busse, Laurence W, Ten Lohuis, Caitlin C, Duggal, Abhijit, Wilson, Jennifer G, Gordon, Alexandra June, Qadir, Nida, Chang, Steven Y, Mallow, Christopher, Rivas, Carolina, Babcock, Hilary M, Kwon, Jennie H, Halasa, Natasha, Grijalva, Carlos G, Rice, Todd W, Stubblefield, William B, Baughman, Adrienne, Womack, Kelsey N, Rhoads, Jillian P, Lindsell, Christopher J, Hart, Kimberly W, Zhu, Yuwei, Adams, Katherine, Schrag, Stephanie J, Olson, Samantha M, Kobayashi, Miwako, Verani, Jennifer R, Patel, Manish M, and Self, Wesley H
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Genetics ,Immunization ,Clinical Research ,Prevention ,Vaccine Related ,Comparative Effectiveness Research ,Good Health and Well Being ,COVID-19 ,COVID-19 Vaccines ,Case-Control Studies ,Hospitalization ,Humans ,Immunization Schedule ,Prospective Studies ,SARS-CoV-2 ,Severity of Illness Index ,United States ,Influenza and Other Viruses in the Acutely Ill (IVY) Network ,Clinical Sciences ,Public Health and Health Services ,General & Internal Medicine - Abstract
ObjectivesTo characterize the clinical severity of covid-19 associated with the alpha, delta, and omicron SARS-CoV-2 variants among adults admitted to hospital and to compare the effectiveness of mRNA vaccines to prevent hospital admissions related to each variant.DesignCase-control study.Setting21 hospitals across the United States.Participants11 690 adults (≥18 years) admitted to hospital: 5728 with covid-19 (cases) and 5962 without covid-19 (controls). Patients were classified into SARS-CoV-2 variant groups based on viral whole genome sequencing, and, if sequencing did not reveal a lineage, by the predominant circulating variant at the time of hospital admission: alpha (11 March to 3 July 2021), delta (4 July to 25 December 2021), and omicron (26 December 2021 to 14 January 2022).Main outcome measuresVaccine effectiveness calculated using a test negative design for mRNA vaccines to prevent covid-19 related hospital admissions by each variant (alpha, delta, omicron). Among patients admitted to hospital with covid-19, disease severity on the World Health Organization's clinical progression scale was compared among variants using proportional odds regression.ResultsEffectiveness of the mRNA vaccines to prevent covid-19 associated hospital admissions was 85% (95% confidence interval 82% to 88%) for two vaccine doses against the alpha variant, 85% (83% to 87%) for two doses against the delta variant, 94% (92% to 95%) for three doses against the delta variant, 65% (51% to 75%) for two doses against the omicron variant; and 86% (77% to 91%) for three doses against the omicron variant. In-hospital mortality was 7.6% (81/1060) for alpha, 12.2% (461/3788) for delta, and 7.1% (40/565) for omicron. Among unvaccinated patients with covid-19 admitted to hospital, severity on the WHO clinical progression scale was higher for the delta versus alpha variant (adjusted proportional odds ratio 1.28, 95% confidence interval 1.11 to 1.46), and lower for the omicron versus delta variant (0.61, 0.49 to 0.77). Compared with unvaccinated patients, severity was lower for vaccinated patients for each variant, including alpha (adjusted proportional odds ratio 0.33, 0.23 to 0.49), delta (0.44, 0.37 to 0.51), and omicron (0.61, 0.44 to 0.85).ConclusionsmRNA vaccines were found to be highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants, but three vaccine doses were required to achieve protection against omicron similar to the protection that two doses provided against the delta and alpha variants. Among adults admitted to hospital with covid-19, the omicron variant was associated with less severe disease than the delta variant but still resulted in substantial morbidity and mortality. Vaccinated patients admitted to hospital with covid-19 had significantly lower disease severity than unvaccinated patients for all the variants.
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- 2022
58. A review on arbitrarily regular conforming virtual element methods for elliptic partial differential equations
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Antonietti, Paola Francesca, Manzini, Gianmarco, Scacchi, Simone, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
The Virtual Element Method is well suited to the formulation of arbitrarily regular Galerkin approximations of elliptic partial differential equations of order $2p_1$, for any integer $p_1\geq 1$. In fact, the virtual element paradigm provides a very effective design framework for conforming, finite dimensional subspaces of $H^{p_2}(\Omega)$, $\Omega$ being the computational domain and $p_2\geq p_1$ another suitable integer number. In this study, we first present an abstract setting for such highly regular approximations and discuss the mathematical details of how we can build conforming approximation spaces with a global high-order continuity on $\Omega$. Then, we illustrate specific examples in the case of second- and fourth-order partial differential equations, that correspond to the cases $p_1=1$ and $2$, respectively. Finally, we investigate numerically the effect on the approximation properties of the conforming highly-regular method that results from different choices of the degree of continuity of the underlying virtual element spaces and how different stabilization strategies may impact on convergence., Comment: 19 pages, 7 tables, 4 figures
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- 2021
59. Low-Cost Configurable Electronic Load for Lithium Ion Batteries Testing.
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Niccolò Nicodemo, Roberto Di Rienzo, Alessandro Verani, Federico Baronti, Roberto Roncella, and Roberto Saletti
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- 2023
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60. Comparison of Lithium-Ion Battery SoC Estimation Accuracy of LSTM Neural Network Trained with Experimental and Synthetic Datasets.
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Luca Amyn Hattouti, Roberto Di Rienzo, Niccolò Nicodemo, Alessandro Verani, Federico Baronti, Roberto Roncella, and Roberto Saletti
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- 2023
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61. Novel Battery Parallelization Approach Using DC/DC Partial Power Converter in Micro-Grids.
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Gianluca Simonte, Roberto Di Rienzo, Niccolò Nicodemo, Alessandro Verani, Federico Baronti, Roberto Roncella, and Roberto Saletti
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- 2023
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62. On Arbitrarily Regular Conforming Virtual Element Methods for Elliptic Partial Differential Equations
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Antonietti, P. F., Manzini, G., Scacchi, S., Verani, M., Barth, Timothy J., Series Editor, Griebel, Michael, Series Editor, Keyes, David E., Series Editor, Nieminen, Risto M., Series Editor, Roose, Dirk, Series Editor, Schlick, Tamar, Series Editor, Melenk, Jens M., editor, Perugia, Ilaria, editor, Schöberl, Joachim, editor, and Schwab, Christoph, editor
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- 2023
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63. In Vitro Potential Virucidal Effect Evaluation of Xibornol on Human Adenovirus Type 5, Human Rhinovirus Type 13, Human Coronavirus 229E, Human Parainfluenza Virus Type 1, and Human Respiratory Syncytial Virus
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Verani, Marco, Federigi, Ileana, Lauretani, Giulia, Muzio, Sara, Carducci, Annalaura, and Donelli, Gianfranco, editor
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- 2023
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64. Low-Cost Lithium-Ion Battery Characterization Setup Based on Auxiliary Batteries
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Nicodemo, Niccolò, Di Rienzo, Roberto, Verani, Alessandro, Baronti, Federico, Roncella, Roberto, Saletti, Roberto, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Berta, Riccardo, editor, and De Gloria, Alessandro, editor
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- 2023
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65. Optimized numerical solutions of SIRDVW multiage model controlling SARS-CoV-2 vaccine roll out: An application to the Italian scenario
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Giovanni Ziarelli, Luca Dede’, Nicola Parolini, Marco Verani, and Alfio Quarteroni
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Optimal control ,Numerical analysis ,Vaccination campaign ,Age-stratified model ,SARS-CoV-2 ,COVID19 ,Infectious and parasitic diseases ,RC109-216 - Abstract
In the context of SARS-CoV-2 pandemic, mathematical modelling has played a fundamental role for making forecasts, simulating scenarios and evaluating the impact of preventive political, social and pharmaceutical measures. Optimal control theory represents a useful mathematical tool to plan the vaccination campaign aimed at eradicating the pandemic as fast as possible. The aim of this work is to explore the optimal prioritisation order for planning vaccination campaigns able to achieve specific goals, as the reduction of the amount of infected, deceased and hospitalized in a given time frame, among age classes. For this purpose, we introduce an age stratified SIR-like epidemic compartmental model settled in an abstract framework for modelling two-doses vaccination campaigns and conceived with the description of COVID19 disease. Compared to other recent works, our model incorporates all stages of the COVID-19 disease, including death or recovery, without accounting for additional specific compartments that would increase computational complexity and that are not relevant for our purposes. Moreover, we introduce an optimal control framework where the model is the state problem while the vaccine doses administered are the control variables. An extensive campaign of numerical tests, featured in the Italian scenario and calibrated on available data from Dipartimento di Protezione Civile Italiana, proves that the presented framework can be a valuable tool to support the planning of vaccination campaigns. Indeed, in each considered scenario, our optimization framework guarantees noticeable improvements in terms of reducing deceased, infected or hospitalized individuals with respect to the baseline vaccination policy.
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- 2023
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66. Post-mortem investigation of deaths due to pneumonia in children aged 1–59 months in sub-Saharan Africa and South Asia from 2016 to 2022: an observational study
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Adam, Yasmin, Agaya, Janet, Ahmed, A.S.M. Nawshad Uddin, Ahmed, Dilruba, Alemu, Addisu, Ali, Solomon, Ameh, Soter, Aol, George, Argeseanu, Solveig, Ariuman, Farida, Balogun, Oluseyi, Bari, Sanwarul, Basket, Margaret, Begum, Ferdousi, Bhandari, Manu, Blevins, John, Bunn, James, Bursuc, Courtney, Cain, Carrie Jo, Chawana, Richard, Chawla, Kiranpreet, Chukwuegbo, Cornell, Diarra, Kounandji, Diarra, Tiéman, Diaz, Maureen, Duduyemi, Babatunde, Fairchild, Karen D., Flora, Meerjady Sabrina, Fritz, Ashleigh, Garel, Mischka, Gaume, Brigitte, Gizaw, Mahlet Abayneh, Govender, Nelesh P., Greene, Carol L., Gure, Tadesse, Halu, Binyam, Hoque, Mahbubul, Hwinya, Cleopas, Ibrahim, Alexander M., Igunza, Kitiezo Aggrey, Islam, Ferdousi, Ita, Okokon, Jambai, Amara, Johnson, J. Kristie, Juma, Jane, Kaluma, Erick, Kamal, Mohammed, Kaykay, Osman, Kenneh, Sartie, Khagayi, Sammy, Koka, Rima, Kone, Diakaridia, Koplan, Jeffrey P., Kourouma, Nana, Kowuor, Dickens, LaHatte, Kristin, Lala, Sanjay G., Lee, Kyu Han, Liu, Lucy, Lombaard, Hennie, Maixenchs, Maria, Manhique, Zara, Mannah, Margaret, Martines, Roosecelis, Mash, Ronald, Mehta, Ashka, Menéndez, Clara, Misore, Thomas, Mocumbi, Sibone, Moseray, Andrew, Moses, Francis, Muga, Christopher, Munguambe, Khátia, Myburgh, Nellie, Nair, Shailesh, Ndagurwa, Pedzisai, Nhacolo, Ariel, Nhampossa, Tacilta, Nwajiobi, Princewill, Ochola, Christine, Oliech, Richard, Oluoch, Bernard, Onwuchekwa, Uma U., Onyango, Peter Nyamthimba, Orlien, Stian MS, Otieno, Peter, Oundo, Joseph, Owuor, Harun, Parveen, Shahana, Petersen, Karen, Pratt, Samuel, Rahman, Mahbubur, Rahman, Mohammad Mosiur, Rahman, Mustafizur, Raymer, Sarah, Ritter, Jana, Salzberg, Navit T., Samura, Solomon, Sannoh, Sulaiman, Sanogo, Doh, Seppeh, Martin, Sesay, Tom, Sesay, Joseph Kamanda, Shirin, Tahmina, Sissoko, Seydou, Smart, Francis, Sorour, Gillian, Squire, James, Swaray-Deen, Alim, Swart, Peter J., Tarawally, Fatmata Bintu, Tasnim, Saria, Temesgen, Fikremelekot, Tennant, Sharon M., Traore, Cheick Bougadari, Traore, Awa, Velaphi, Sithembiso, Vyas, Kurt, Wadhwa, Ashutosh, Wadula, Jeannette, Waller, Jessica, Wanga, Valentine, Warang, Shamta, Were, Joyce Akinyi, Wilson, Tais, Winchell, Jonas, Wise, Amy, Witherbee, Jakob, Yeshi, Melisachew Mulatu, Zaman, K., Mahtab, Sana, Blau, Dianna M, Madewell, Zachary J, Ogbuanu, Ikechukwu, Ojulong, Julius, Lako, Sandra, Legesse, Hailemariam, Bangura, Joseph S, Bassat, Quique, Mandomando, Inacio, Xerinda, Elisio, Fernandes, Fabiola, Varo, Rosauro, Sow, Samba O, Kotloff, Karen L, Tapia, Milagritos D, Keita, Adama Mamby, Sidibe, Diakaridia, Onyango, Dickens, Akelo, Victor, Gethi, Dickson, Verani, Jennifer R, Revathi, Gunturu, Scott, J Anthony G, Assefa, Nega, Madrid, Lola, Bizuayehu, Hiwot, Tirfe, Tseyon Tesfaye, El Arifeen, Shams, Gurley, Emily S, Islam, Kazi Munisul, Alam, Muntasir, Zahid Hossain, Mohammad, Dangor, Ziyaad, Baillie, Vicky L, Hale, Martin, Mutevedzi, Portia, Breiman, Robert F, Whitney, Cynthia G, and Madhi, Shabir A
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- 2024
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67. Effect of biorejuvenator types on microstructure, mechanistic performance, and resilient modulus prediction model of asphalt concrete containing recycled materials in Indonesia
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Sihombing, Atmy Verani Rouly, Subagio, Bambang Sugeng, Hariyadi, Eri Susanto, Mulyadi, Agah Muhammad, Utami, Retno, and Sihombing, Reza Phalevi
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- 2024
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68. Child deaths caused by Klebsiella pneumoniae in sub-Saharan Africa and south Asia: a secondary analysis of Child Health and Mortality Prevention Surveillance (CHAMPS) data
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Verani, Jennifer R, Blau, Dianna M, Gurley, Emily S, Akelo, Victor, Assefa, Nega, Baillie, Vicky, Bassat, Quique, Berhane, Mussie, Bunn, James, Cossa, Anelsio C A, El Arifeen, Shams, Gunturu, Revathi, Hale, Martin, Igunza, Aggrey, Keita, Adama M, Kenneh, Sartie, Kotloff, Karen L, Kowuor, Dickens, Mabunda, Rita, Madewell, Zachary J, Madhi, Shabir, Madrid, Lola, Mahtab, Sana, Miguel, Judice, Murila, Florence V, Ogbuanu, Ikechukwu U, Ojulong, Julius, Onyango, Dickens, Oundo, Joe O, Scott, J Anthony G, Sow, Samba, Tapia, Milagritos, Traore, Cheick B, Velaphi, Sithembiso, Whitney, Cynthia G, Mandomando, Inacio, and Breiman, Robert F
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- 2024
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69. Spatial patterns of beta diversity in marine benthic assemblages from coastal areas of southern Brazil and their implications for conservation
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Costa Barrilli, Germano Henrique, Gomes do Vale, Julia, Chahad-Ehlers, Samira, Verani, José Roberto, and Branco, Joaquim Olinto
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- 2024
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70. Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil
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Reis, Joice Neves, Azevedo, Jailton, de Oliveira, Aisla Mércia Lazaro, Menezes, Ana Paula de Oliveira, Pedrosa, Mayara, dos Santos, Milena Soares, Ribeiro, Laise Carvalho, Freitas, Humberto Fonseca de, Gouveia, Edilane Lins, Teles, Marcelo Bastos, Carvalho, Maria da Glória, Reis, Mitermayer Galvão, Nascimento-Carvalho, Cristiana, and Verani, Jennifer R.
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- 2024
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71. Long-term impact of 10-valent pneumococcal conjugate vaccine in Kenya: Nasopharyngeal carriage among children in a rural and an urban site six years after introduction
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Verani, Jennifer R., Omondi, Daniel, Odoyo, Arthur, Odiembo, Herine, Ouma, Alice, Ngambi, Juliet, Aol, George, Audi, Allan, Kiplangat, Samwel, Agumba, Noel, Munywoki, Patrick K., Onyango, Clayton, Hunsperger, Elizabeth, Farrar, Jennifer L., Kim, Lindsay, Kobayashi, Miwako, Breiman, Robert F., Pimenta, Fabiana C., da Gloria Carvalho, Maria, Lessa, Fernanda C., Whitney, Cynthia G., and Bigogo, Godfrey
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- 2024
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72. Putting theory into practice: A novel methodological framework for assessing cities' compliance with the 15-min city concept
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Sdoukopoulos, Alexandros, Papadopoulos, Efthymis, Verani, Eleni, and Politis, Ioannis
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- 2024
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73. In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring
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Giordano, Elisa, Liori, Barbara, Cecchini, Irene, Verani, Roberta, and Leone, Lidia
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- 2024
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74. The conforming virtual element method for polyharmonic and elastodynamics problems: a review
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Antonietti, Paola Francesca, Manzini, Gianmarco, Mazzieri, Ilario, Scacchi, Simone, and Verani, Marco
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Mathematics - Numerical Analysis ,65L10, 65L20, 65L60 - Abstract
In this paper, we review recent results on the conforming virtual element approximation of polyharmonic and elastodynamics problems. The structure and the content of this review is motivated by three paradigmatic examples of applications: classical and anisotropic Cahn-Hilliard equation and phase field models for brittle fracture, that are briefly discussed in the first part of the paper. We present and discuss the mathematical details of the conforming virtual element approximation of linear polyharmonic problems, the classical Cahn-Hilliard equation and linear elastodynamics problems., Comment: 30 pages, 7 figures. arXiv admin note: text overlap with arXiv:1912.07122
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- 2021
75. A diffuse interface box method for elliptic problems
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Negrini, G., Parolini, N., and Verani, M.
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Mathematics - Numerical Analysis ,65N08, 65N85 - Abstract
We introduce a diffuse interface box method (DIBM) for the numerical approximation on complex geometries of elliptic problems with Dirichlet boundary conditions. We derive a priori $H^1$ and $L^2$ error estimates highlighting the r\^{o}le of the mesh discretization parameter and of the diffuse interface width. Finally, we present a numerical result assessing the theoretical findings., Comment: 10 pages, 5 figures, submitted on Applied Mathematics Letters
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- 2021
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76. SUIHTER: A new mathematical model for COVID-19. Application to the analysis of the second epidemic outbreak in Italy
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Parolini, Nicola, Dede', Luca, Antonietti, Paola F., Ardenghi, Giovanni, Manzoni, Andrea, Miglio, Edie, Pugliese, Andrea, Verani, Marco, and Quarteroni, Alfio
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Quantitative Biology - Populations and Evolution ,Mathematics - Numerical Analysis - Abstract
The COVID-19 epidemic is the last of a long list of pandemics that have affected humankind in the last century. In this paper, we propose a novel mathematical epidemiological model named SUIHTER from the names of the seven compartments that it comprises: susceptible uninfected individuals (S), undetected (both asymptomatic and symptomatic) infected (U), isolated (I), hospitalized (H), threatened (T), extinct (E), and recovered (R). A suitable parameter calibration that is based on the combined use of least squares method and Markov Chain Monte Carlo (MCMC) method is proposed with the aim of reproducing the past history of the epidemic in Italy, surfaced in late February and still ongoing to date, and of validating SUIHTER in terms of its predicting capabilities. A distinctive feature of the new model is that it allows a one-to-one calibration strategy between the model compartments and the data that are daily made available from the Italian Civil Protection. The new model is then applied to the analysis of the Italian epidemic with emphasis on the second outbreak emerged in Fall 2020. In particular, we show that the epidemiological model SUIHTER can be suitably used in a predictive manner to perform scenario analysis at national level., Comment: 25 pages
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- 2021
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77. Wastewater Treatment Plants Performance for Reuse: Evaluation of Bacterial and Viral Risks
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Ileana Federigi, Roberto Salvadori, Giulia Lauretani, Anna Leone, Simone Lippi, Francesca Marvulli, Alessandra Pagani, Marco Verani, and Annalaura Carducci
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reclaimed water ,wastewater reuse ,sewage ,reclamation facility ,Regulation 741/2020 ,index pathogen ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Reusing reclaimed water is of paramount importance to achieve the 2030 Agenda for Sustainable Development Goals 6 and 13. In Europe, a recent Regulation set minimum requirements for water reuse in agriculture. However, some challenges remain considering microbial risks and their prevention. In this study, two urban wastewater treatment plants (WWTPs) were investigated from the perspective of reuse. A five-year investigation was performed on routine monitoring parameters collected under different weather conditions (wet/dry) and treatments (chlorination/non-chlorination) in inlet and outlet samples. Moreover, a three-month investigation focused on microbial parameters, including indicators, index pathogens (Human Adenovirus—HAdV, Salmonella spp.), and other viral pathogens (norovirus, enterovirus, and SARS-CoV-2). The long-term study revealed the compliance of both WWTPs for chemical parameters (organic substances and solids) in more than 90% of samples, whereas for Escherichia coli, the compliance ranged from 96.1% with chlorination under dry weather to 16.7% without chlorination in wet days. E. coli was positively associated with chemical oxygen demand (COD), which could be a promising and online measurable proxy of E. coli. The study on microbial performance demonstrated sound reliability in detecting E. coli as a suitable surrogate for Salmonella in chlorinated effluents, but neither bacterial nor viral indicators are able to represent HAdV. Although chlorination was able to remove most of the pathogens considered, the compliance with microbial indicators seems insufficient to represent viral water safety.
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- 2024
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78. Stability analysis of polytopic Discontinuous Galerkin approximations of the Stokes problem with applications to fluid-structure interaction problems
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Antonietti, Paola F., Mascotto, Lorenzo, Verani, Marco, and Zonca, Stefano
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Mathematics - Numerical Analysis - Abstract
We present a stability analysis of the Discontinuous Galerkin method on polygonal and polyhedral meshes (PolyDG) for the Stokes problem. In particular, we analyze the discrete inf-sup condition for different choices of the polynomial approximation order of the velocity and pressure approximation spaces. To this aim, we employ a generalized inf-sup condition with a pressure stabilization term. We also prove a priori hp-version error estimates in suitable norms. We numerically check the behaviour of the inf-sup constant and the order of convergence with respect to the mesh configuration, the mesh-size, and the polynomial degree. Finally, as a relevant application of our analysis, we consider the PolyDG approximation for a fluid-structure interaction problem and we numerically explore the stability properties of the method.
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- 2020
79. Effectiveness of COVID-19 Vaccines in Preventing Hospitalization Among Adults Aged ≥65 Years - COVID-NET, 13 States, February-April 2021.
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Moline, Heidi L, Whitaker, Michael, Deng, Li, Rhodes, Julia C, Milucky, Jennifer, Pham, Huong, Patel, Kadam, Anglin, Onika, Reingold, Arthur, Chai, Shua J, Alden, Nisha B, Kawasaki, Breanna, Meek, James, Yousey-Hindes, Kimberly, Anderson, Evan J, Farley, Monica M, Ryan, Patricia A, Kim, Sue, Nunez, Val Tellez, Como-Sabetti, Kathryn, Lynfield, Ruth, Sosin, Daniel M, McMullen, Chelsea, Muse, Alison, Barney, Grant, Bennett, Nancy M, Bushey, Sophrena, Shiltz, Jessica, Sutton, Melissa, Abdullah, Nasreen, Talbot, H Keipp, Schaffner, William, Chatelain, Ryan, Ortega, Jake, Murthy, Bhavini Patel, Zell, Elizabeth, Schrag, Stephanie J, Taylor, Christopher, Shang, Nong, Verani, Jennifer R, and Havers, Fiona P
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Humans ,Vaccines ,Synthetic ,Hospitalization ,Aged ,United States ,COVID-19 ,COVID-19 Vaccines ,Aging ,Prevention ,Vaccine Related ,Immunization ,3.4 Vaccines ,Infection ,General & Internal Medicine - Abstract
Clinical trials of COVID-19 vaccines currently authorized for emergency use in the United States (Pfizer-BioNTech, Moderna, and Janssen [Johnson & Johnson]) indicate that these vaccines have high efficacy against symptomatic disease, including moderate to severe illness (1-3). In addition to clinical trials, real-world assessments of COVID-19 vaccine effectiveness are critical in guiding vaccine policy and building vaccine confidence, particularly among populations at higher risk for more severe illness from COVID-19, including older adults. To determine the real-world effectiveness of the three currently authorized COVID-19 vaccines among persons aged ≥65 years during February 1-April 30, 2021, data on 7,280 patients from the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) were analyzed with vaccination coverage data from state immunization information systems (IISs) for the COVID-NET catchment area (approximately 4.8 million persons). Among adults aged 65-74 years, effectiveness of full vaccination in preventing COVID-19-associated hospitalization was 96% (95% confidence interval [CI] = 94%-98%) for Pfizer-BioNTech, 96% (95% CI = 95%-98%) for Moderna, and 84% (95% CI = 64%-93%) for Janssen vaccine products. Effectiveness of full vaccination in preventing COVID-19-associated hospitalization among adults aged ≥75 years was 91% (95% CI = 87%-94%) for Pfizer-BioNTech, 96% (95% CI = 93%-98%) for Moderna, and 85% (95% CI = 72%-92%) for Janssen vaccine products. COVID-19 vaccines currently authorized in the United States are highly effective in preventing COVID-19-associated hospitalizations in older adults. In light of real-world data demonstrating high effectiveness of COVID-19 vaccines among older adults, efforts to increase vaccination coverage in this age group are critical to reducing the risk for COVID-19-related hospitalization.
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- 2021
80. Theoretical Framework for Retrospective Studies of the Effectiveness of SARS-CoV-2 Vaccines.
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Lewnard, Joseph A, Patel, Manish M, Jewell, Nicholas P, Verani, Jennifer R, Kobayashi, Miwako, Tenforde, Mark W, Dean, Natalie E, Cowling, Benjamin J, and Lopman, Benjamin A
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Humans ,Vaccines ,Retrospective Studies ,COVID-19 ,SARS-CoV-2 ,COVID-19 Vaccines ,Clinical Research ,Immunization ,Biodefense ,Prevention ,Emerging Infectious Diseases ,Infectious Diseases ,Vaccine Related ,3.4 Vaccines ,Prevention of disease and conditions ,and promotion of well-being ,Infection ,Good Health and Well Being ,Causal inference ,Test-negative design ,Vaccine effectiveness ,Statistics ,Public Health and Health Services ,Epidemiology - Abstract
Observational studies of the effectiveness of vaccines to prevent COVID-19 are needed to inform real-world use. Such studies are now underway amid the ongoing rollout of SARS-CoV-2 vaccines globally. Although traditional case-control and test-negative design studies feature prominently among strategies used to assess vaccine effectiveness, such studies may encounter important threats to validity. Here, we review the theoretical basis for estimation of vaccine direct effects under traditional case-control and test-negative design frameworks, addressing specific natural history parameters of SARS-CoV-2 infection and COVID-19 relevant to these designs. Bias may be introduced by misclassification of cases and controls, particularly when clinical case criteria include common, nonspecific indicators of COVID-19. When using diagnostic assays with high analytical sensitivity for SARS-CoV-2 detection, individuals testing positive may be counted as cases even if their symptoms are due to other causes. The traditional case-control design may be particularly prone to confounding due to associations of vaccination with healthcare-seeking behavior or risk of infection. The test-negative design reduces but may not eliminate this confounding, for instance, if individuals who receive vaccination seek care or testing for less-severe illness. These circumstances indicate the two study designs cannot be applied naively to datasets gathered through public health surveillance or administrative sources. We suggest practical strategies to reduce bias in vaccine effectiveness estimates at the study design and analysis stages.
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- 2021
81. The Informational Centrality of Banks
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Foley-Fisher, Nathan, primary, Gorton, Gary, additional, and Verani, Stéphane, additional
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- 2023
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82. Polytopic Discontinuous Galerkin methods for the numerical modelling of flow in porous media with networks of intersecting fractures
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Antonietti, Paola Francesca, Facciolà, Chiara, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
We present a numerical approximation of Darcy's flow through a porous medium that incorporates networks of fractures with non empty intersection. Our scheme employs PolyDG methods, i.e. discontinuous Galerkin methods on general polygonal and polyhedral (polytopic, for short) grids, featuring elements with edges/faces that may be in arbitrary number (potentially unlimited) and whose measure may be arbitrarily small. Our approach is then very well suited to tame the geometrical complexity featured by most of applications in the computational geoscience field. From the modelling point of view, we adopt a reduction strategy that treats fractures as manifolds of codimension one and we employ the primal version of Darcy's law to describe the flow in both the bulk and the fracture network. In addition, some physically consistent conditions couple the two problems, allowing for jump of pressure at their interface, and they as well prescribe the behaviour of the fluid along the intersections, imposing pressure continuity and flux conservation. Both the bulk and fracture discretizations are obtained employing the Symmetric Interior Penalty DG method extended to the polytopic setting. The key instrument to obtain a polyDG approximation of the problem in the fracture network is the generalization of the concepts of jump and average at the intersection, so that the contribution from all the fractures is taken into account. We prove the well-posedness of the discrete formulation and perform an error analysis obtaining a priori hp-error estimates. All our theoretical results are validated performing preliminary numerical tests with known analytical solution.
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- 2020
83. Anisotropic a posteriori error estimate for the Virtual Element Method
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Antonietti, Paola Francesca, Berrone, Stefano, Borio, Andrea, D'Auria, Alessandro, Verani, Marco, and Weisser, Steffen
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Mathematics - Numerical Analysis - Abstract
We derive an anisotropic a posteriori error estimate for the adaptive conforming Virtual Element approximation of a paradigmatic two-dimensional elliptic problem. In particular, we introduce a quasi-interpolant operator and exploit its approximation results to prove the reliability of the error indicator. We design and implement the corresponding adaptive polygonal anisotropic algorithm. Several numerical tests assess the superiority of the proposed algorithm in comparison with standard polygonal isotropic mesh refinement schemes.
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- 2020
84. Review of the existing maximum residue levels for zoxamide according to Article 12 of Regulation (EC) No 396/2005 and setting of an import tolerance for onions, garlic and shallots
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,fungicide ,MRL review ,Regulation (EC) No 396/2005 ,zoxamide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance zoxamide. To assess the occurrence of zoxamide residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Regulation (EC) No 1107/2009, the MRLs established by the Codex Alimentarius Commission and the European authorisations reported by Member States and the UK (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived, and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still require further consideration by risk managers. Furthermore, in accordance with Article 6 of Regulation (EC) No 396/2005, the Applicant Gowan Crop Protection Ltd, submitted a request to the competent national authority in Latvia to set an import tolerance for zoxamide in onions (extrapolated to garlic and shallots) based on the use authorised in USA. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all crops under assessment. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of zoxamide according to the agricultural practices on onions, garlic and shallots is unlikely to present a risk to consumer health.
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- 2023
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85. Modification of the existing maximum residue level for mandipropamid in radish leaves
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,mandipropamid ,MRL ,pesticide ,radish leaves ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue level (MRL) for the active substance mandipropamid in radish leaves (classified under the subgroup of kales), based on an intended indoor use on radishes. The residue data in radish leaves submitted in support of the request were found to be sufficient to derive an MRL proposal for this commodity. Adequate analytical methods for enforcement are available to control the residues of mandipropamid on the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that long‐term intake of residues resulting from the use of mandipropamid according to the reported agricultural practice is unlikely to present a risk to consumer health. The reliable end points, appropriate for use in regulatory risk assessment are presented.
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- 2023
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86. Targeted review of maximum residue levels (MRLs) for chlorfenapyr
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Katia Chukwubike, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Javier Martinez, Ileana Miron, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
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chlorfenapyr ,consumer risk assessment ,MRL setting ,non‐approved active substance ,residue definitions ,toxicological evaluation ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to review the existing maximum residue levels (MRLs) for the non‐approved active substance chlorfenapyr in view of the possible lowering of the MRL set for tea. This current EU MRL is based on an import tolerance established in 2007. EFSA reviewed the toxicological data assessed by other scientific bodies, proposing toxicological reference values to be used for an indicative risk assessment, noting that the values are affected by additional, non‐standard uncertainties. According to the indicative chronic and acute dietary risk assessment the existing MRL for tea does not pose an unacceptable risk for consumers. Further risk management discussions are required to decide which of the risk management options proposed by EFSA should be implemented in the EU MRL legislation.
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- 2023
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87. Modification of the existing maximum residue levels and setting import tolerances for flupyradifurone and difluoroacetic acid (DFA) in various crops
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,difluoroacetic acid (DFA) ,flupyradifurone ,import tolerance ,MRL ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer AG, Crop Science Division submitted a request to the competent national authority in the Netherlands to modify the existing maximum residue levels (MRL) and to set import tolerances for flupyradifurone and its metabolite difluoroacetic acid (DFA) in various plant commodities. The data submitted in support of the request were found to be sufficient to derive MRL proposals for flupyradifurone and DFA in avocados, mangoes, papayas, asparagus, sesame seeds, sunflower seeds, sugar beet roots and chicory roots. Adequate analytical methods for enforcement are available to control the residues of flupyradifurone and DFA in plant matrices under consideration at the validated limits of quantification (LOQs) of 0.01 and 0.007 mg/kg, respectively. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of flupyradifurone and DFA residues resulting from the use of flupyradifurone according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2023
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88. Modification of the existing maximum residue levels for sulfoxaflor in various commodities
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,MRL ,pesticide ,sulfoxaflor ,various crops ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the Federal Public Service (FPS) Health, Food chain Safety and Environment submitted a request on behalf of Belgium (evaluating Member State, EMS) to modify the existing maximum residue levels (MRL) in okra/lady's fingers and various leaf vegetables, herbs and edible flowers. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all crops under assessment. Adequate analytical methods for enforcement are available to control the residues of sulfoxaflor in plant matrices under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of sulfoxaflor according to the reported agricultural practices is unlikely to present a risk to consumer health.
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- 2023
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89. Targeted review of maximum residue levels (MRLs) for profenofos
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Katia Chukwubike, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Javier Martinez, Ileana Miron, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,MRL setting ,non‐approved active substance ,profenofos ,residue definitions ,toxicological evaluation ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to review the existing maximum residue levels (MRLs) for the non‐approved active substance profenofos in view of the possible lowering of the MRL. EFSA investigated the origin of the current EU MRLs. Existing EU MRLs are based on Codex Maximum Residue Limits still in place or reflect temporary MRLs set from monitoring data. EFSA performed an indicative chronic and acute dietary risk assessment for the list of MRLs to allow risk managers to take the appropriate decisions. For some commodities, further risk management discussions are required to decide which of the risk management options proposed by EFSA should be implemented in the EU MRL legislation.
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- 2023
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90. Setting of an import tolerance for lambda‐cyhalothrin in avocados
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EFSA European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Marta Szot, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
avocados ,consumer risk assessment ,lambda‐cyhalothrin ,MRL ,pesticide ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Greece to set an import tolerance for the active substance lambda‐cyhalothrin in avocados. The data submitted in support of the request were found to be sufficient to derive maximum residue level (MRL) proposals for avocados. Since the general data gap related to toxicity of degradation products formed under sterilisation conditions and identified in the framework of the MRL review has not yet been addressed, a risk management decision is required as to whether it is appropriate to take over the proposed MRLs in the MRL legislation. Adequate analytical methods for enforcement are available to control the residues of lambda‐cyhalothrin in the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of lambda‐cyhalothrin according to the reported agricultural practice is unlikely to present a risk to consumer health. However, the consumer exposure calculation shall be considered provisional, pending the toxicological assessment of the compounds formed under sterilisation conditions.
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- 2023
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91. Setting of an import tolerance for fenazaquin in hops
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
Fenazaquin ,hops ,TBPE ,pesticide ,MRL ,consumer risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Gowan Crop Protection Limited submitted a request to the competent national authority in Greece to set an import tolerance for the active substance fenazaquin in hops imported from the United States of America. The data submitted in support of the request were found to be sufficient to derive an maximum residue limit (MRL) proposal for hops. An adequate analytical method for enforcement is available to control the residues of fenazaquin in the plant matrix under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues of fenazaquin and its toxicologically relevant plant metabolite TBPE resulting from the use of fenazaquin on imported hops from United States according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2023
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92. Prevalence and Missed Cases of Respiratory Distress Syndrome Disease Amongst Neonatal Deaths Enrolled in the Kenya Child Health and Mortality Prevention Surveillance Network (CHAMPS) Program Between 2017 and 2021
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Harun O. Owuor BSc, Victor Akelo MD, Florence Murila PhD, Dickens Onyango PhD, Magdalene Kuria MD, Emily Rogena PhD, Gunturu Revathi PhD, Paul Mitei MD, Solomon Sava MD, Joyce Were MSc, Aggrey Igunza BSc, Sammy Khagayi PhD, Emily Zielinski-Gutierrez Dr PH, Sarah Hawi MPH, Dickson Gethi BSc, Jennifer R. Verani MD, Clayton Onyango PhD, Dianna M. Blau PhD, and Beth A. Tippett Barr PhD
- Subjects
Pediatrics ,RJ1-570 - Abstract
Objectives. To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021. Methods. We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy. Results. Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases. Most cases received suboptimal levels of supplemental oxygen, and critical interventions like surfactant replacement therapy and mechanical ventilation were not adequately utilized when available. Conclusion. The study highlights the urgent need for improved diagnosis and management of RDS, emphasizing the importance of increasing clinical suspicion and enhancing training in its clinical management to reduce mortality rates.
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- 2023
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93. Mortality patterns over a 10-year period in Kibera, an urban informal settlement in Nairobi, Kenya, 2009–2018
- Author
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Clifford Oduor, Irene Omwenga, Alice Ouma, Robert Mutinda, Samwel Kiplangat, Ondari D. Mogeni, Leonard Cosmas, Allan Audi, George S. Odongo, David Obor, Robert Breiman, Joel Montgomery, George Agogo, Patrick Munywoki, Godfrey Bigogo, and Jennifer R. Verani
- Subjects
mortality rate ,cause of death ,urban informal settlements ,kibera ,kenya ,Public aspects of medicine ,RA1-1270 - Abstract
Background Reliable mortality data are important for evaluating the impact of health interventions. However, data on mortality patterns among populations living in urban informal settlements are limited. Objectives To examine the mortality patterns and trends in an urban informal settlement in Kibera, Nairobi, Kenya, Methods Using data from a population-based surveillance platform we estimated overall and cause-specific mortality rates for all age groups using person-year-observation (pyo) denominators and using Poisson regression tested for trends in mortality rates over time. We compared associated mortality rates across groups using incidence rate ratios (IRR). Assignment of probable cause(s) of death was done using the InterVA-4 model. Results We registered 1134 deaths from 2009 to 2018, yielding a crude mortality rate of 4.4 (95% Confidence Interval [CI]4.2–4.7) per 1,000 pyo. Males had higher overall mortality rates than females (incidence rate ratio [IRR], 1.44; 95% CI, 1.28–1.62). The highest mortality rate was observed among children aged
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- 2023
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94. Targeted review of maximum residue levels (MRLs) for dicofol
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Marco Binaglia, Luis Carrasco Cabrera, Irene Castellan, Anna Federica Castoldi, Arianna Chiusolo, Katia Chukwubike, Federica Crivellente, Monica Del Aguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Frederique Istace, Samira Jarrah, Anna Lanzoni, Renata Leuschner, Iris Mangas, Javier Martinez, Ileana Miron, Stefanie Nave, Martina Panzarea, Juan Manuel Parra Morte, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Andrea Terron, Anne Theobald, Manuela Tiramani, and Alessia Verani
- Subjects
consumer risk assessment ,dicofol ,MRL setting ,non‐approved active substance ,residue definitions ,toxicological evaluation ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to review the existing maximum residue levels (MRLs) for the non‐approved active substance dicofol in view of the possible lowering of the MRL. EFSA investigated the origin of the current EU MRLs. All existing EU MRLs reflect previously authorised uses in the EU or are based on obsolete Codex Maximum Residue Limits. Furthermore, in view of the limitations of the toxicological dataset and related uncertainties, the existing toxicological reference values derived at the EU level cannot be confirmed for dicofol. EFSA therefore proposed lowering all existing EU MRLs for dicofol to the limit of quantification.
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- 2023
- Full Text
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95. Modification of the existing maximum residue level for propamocarb in honey
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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consumer risk assessment ,honey ,MRL ,pesticide ,propamocarb ,propamocarb hydrochloride ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer AG Crop Science Division submitted a request to the competent national authority in Greece to modify the existing maximum residue level (MRL) for the active substance propamocarb in honey. The data submitted in support of the request were found to be sufficient to derive MRL proposals for honey. Adequate analytical methods for enforcement are available to control the residues of propamocarb on the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of propamocarb according to the reported agricultural practice is unlikely to present a risk to consumer health.
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- 2023
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96. The epidemiology of fecal carriage of nontyphoidal Salmonella among healthy children and adults in three sites in Kenya.
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Esther M Muthumbi, Alfred Mwanzu, Cecilia Mbae, Godfrey Bigogo, Angela Karani, Salim Mwarumba, Jennifer R Verani, Samuel Kariuki, and J Anthony G Scott
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundDespite the importance of non-Typhoidal Salmonella (NTS) disease in Africa, epidemiologic data on carriage and transmission are few. These data are important to understand the transmission of NTS in Africa and to design control strategies.MethodTo estimate the prevalence of stool carriage of NTS in Kenya, we conducted a cross-sectional study in Kilifi, Nairobi, and Siaya, sites with a low, moderate and high incidence of invasive NTS disease, respectively. At each site, we randomly selected 100 participants in each age-group of 0-11 months, 12-59 months, 5-14 years, 15-54 years and ≥55 years. We collected stool, venous blood (for hemoglobin and malaria rapid tests), anthropometric measurements, and administered a questionnaire on Water Access Sanitation and Hygiene (WASH) practices. Stool samples were cultured on selective agar for Salmonella; suspect isolates underwent serotyping and antimicrobial susceptibility testing.ResultOverall, 53 (3.5%) isolates of NTS were cultured from 1497 samples. Age-adjusted prevalence was 13.1% (95%CI 8.8-17.4) in Kilifi, 0.4% (95%CI 0-1.3) in Nairobi, and 0.9% (95%CI 0-2.0) in Siaya. Prevalence was highest among those aged 15-54 years (6.2%). Of 53 isolates; 5 were S. Enteritidis, 1 was S. Typhimurium. No S. Typhi was isolated. None of the risk factors were associated with carriage of NTS. All isolates were susceptible to all antibiotics tested, including ampicillin, chloramphenicol, ciprofloxacin and co-trimoxazole.ConclusionPrevalence of fecal carriage was high in Kilifi, an area of low incidence of invasive NTS disease and was low in areas of higher incidence in Nairobi and Siaya. The age-prevalence, risk factors, geographical and serotype distribution of NTS in carriage differs from invasive disease.
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- 2023
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97. Evaluation of confirmatory data following the Article 12 MRL review for S‐metolachlor
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European Food Safety Authority (EFSA), Giulia Bellisai, Giovanni Bernasconi, Luis Carrasco Cabrera, Irene Castellan, Monica delAguila, Lucien Ferreira, German Giner Santonja, Luna Greco, Samira Jarrah, Renata Leuschner, Javier Martinez Perez, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Silvia Ruocco, Miguel Santos, Alessia Pia Scarlato, Anne Theobald, Manuela Tiramani, and Alessia Verani
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S‐metolachlor ,confirmatory data ,pesticide ,MRL review ,risk assessment ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The applicant Syngenta Crop Protection AG submitted a request to the competent national authority in Germany to evaluate the confirmatory data that were identified for S‐metolachlor in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. To address the data gaps, a new freezer storage stability study for S‐metolachlor in commodities with high acid content was submitted. However, the data gap on storage stability was considered only partially addressed for strawberries because, in the absence of information on the storage time interval of the samples of the residue trials performed on strawberries, no conclusion on the validity of these trials could be drawn. The data gap on the lack of trials to support the good agricultural practice (GAP) on pineapples was not addressed. Consequently, the existing tentative MRLs for strawberries and pineapple cannot be confirmed and EFSA recommends lowering these MRLs to the enforcement limit of quantification (LOQ). Since a new lower LOQ for enforcement in high acid content commodities of 0.01 mg/kg has been validated, it is proposed to change the existing MRL value from 0.05* to 0.01* mg/kg for these two commodities.
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- 2023
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98. Correcting for measurement error in assessing gestational age in a low-resource setting: a regression calibration approach
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George O. Agogo, Jennifer R. Verani, Nancy A. Otieno, Bryan O. Nyawanda, Marc-Alain Widdowson, and Sandra S. Chaves
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attenuation ,fundal height ,gestational age ,last menstrual period ,measurement error ,preterm ,Medicine (General) ,R5-920 - Abstract
IntroductionMeasurement error in gestational age (GA) may bias the association of GA with a health outcome. Ultrasound-based GA is considered the gold standard and is not readily available in low-resource settings. We corrected for measurement error in GA based on fundal height (FH) and date of last menstrual period (LMP) using ultrasound from the sub-cohort and adjusted for the bias in associating GA with neonatal mortality and low birth weight (
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- 2023
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99. The Virtual Element Method for a Minimal Surface Problem
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Antonietti, Paola Francesca, Bertoluzza, Silvia, Prada, Daniele, and Verani, Marco
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Mathematics - Numerical Analysis - Abstract
In this paper we consider the Virtual Element discretization of a minimal surface problem, a quasi-linear elliptic partial differential equation modeling the problem of minimizing the area of a surface subject to a prescribed boundary condition. We derive optimal error estimate and present several numerical tests assessing the validity of the theoretical results.
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- 2019
100. The virtual element method for linear elastodynamics models. Convergence, stability and dissipation-dispersion analysis
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Antonietti, P. F., Manzini, G., Mazzieri, I., Mourad, H., and Verani, M.
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Mathematics - Numerical Analysis - Abstract
We design the conforming virtual element method for the numerical approximation of the two dimensional elastodynamics problem. We prove stability and convergence of the semi-discrete approximation and derive optimal error estimates under $h$- and $p$-refinement in both the energy and the $L^2$ norms. The performance of the proposed virtual element method is assessed on a set of different computational meshes, including non-convex cells up to order four in the $h$-refinement setting. Exponential convergence is also experimentally observed under p-refinement. Finally, we present a dispersion-dissipation analysis for both the semi-discrete and fully-discrete schemes, showing that polygonal meshes behave as classical simplicial/quadrilateral grids in terms of dispersion-dissipation properties.
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- 2019
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