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Colon cancer is a major human cancer accounting for about a tenth of all cancer cases thus making it among the top three cancers in terms of incidence as well as mortality. Metastasis to distant organs, particularly to liver, is the primary reason for associated mortality. Chemokines, the chemo-attractants for various immune cells, have increasingly been reported to be involved in cancer initiation and progression, including in colon cancer. Here we discuss the available knowledge on the role of several chemokines, such as, CCL2, CCL3, CCL5, CXCL1, CXCL2, CXCL8 in colon cancer progression. CCL20 is one chemokine with emerging evidence for its role in influencing colon cancer tumor microenvironment through the documents effects on fibroblasts, macrophages and immune cells. We focus on CCL20 and its receptor CCR6 as promising factors that affect multiple levels of colon cancer progression. They interact with several cytokines and TLR receptors leading to increased aggressiveness, as supported by multitude of evidence from in vitro, in vivo studies as well as human patient samples. CCL20-CCR6 bring about their biological effects through regulation of several signaling pathways, including, ERK and NF-κB pathways, in addition to the epithelial-mesenchymal transition. Signaling involving CCL20-CCR6 has profound effect on colon cancer hepatic metastasis. Combined with elevated CCL20 levels in colon tumors and metastatic patients, the above information points to a need for further evaluation of chemokines as diagnostic and/or prognostic biomarkers.

Objective: To explore whether there is a specific clinical effect of acupuncture in the treatment of chronic prostatitis. Methods: A total of 52 patients with chronic prostatitis were randomly divided into an acupuncture group (24 cases) and a placebo acupuncture group (28 cases). During the treatment, 1 case was dropped out in the placebo acupuncture group and 51 patients accomplished the clinical trial finally in two groups. In the acupuncture group, Shenshū (肾俞BL23), Zhōngliao (中髎BL33), Huiyang (会阳BL35) and Sānyīnjiāo (三阴交SP6) were selected. In the placebo acupuncture group, the non-meridian points located lateral to BL23, BL33, BL35 and SP6 were selected respectively. The duration of treatment was 8 weeks in each group. In the first 4 weeks of treatment, the treatment was given once every two days, three times weekly. In the last 4 weeks of treatment, the treatment was given once every three days, twice a week. Totally, 20 acupuncture treatments were required in the whole trial. Before treatment, in week 4 and 8 of treatment and in follow-up, National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score and the comprehensive effect were evaluated in the two groups successively. Results: In week 4 and 8 of treatment, NIH-CPSI score in the acupuncture group was lower than that before treatment respectively (both P Conclusion: Acupuncture relieves pelvic pain and urination symptoms and has a certain of long-term effect in patients with chronic prostatitis.

Anion-exchange membrane fuel cells and Zn–air batteries based on non-Pt group metal catalysts typically suffer from sluggish cathodic oxygen reduction. Designing advanced catalyst architectures to improve the catalyst’s oxygen reduction activity and boosting the accessible site density by increasing metal loading and site utilization are potential ways to achieve high device performances. Herein, we report an interfacial assembly strategy to achieve binary single-atomic Fe/Co-Nx with high mass loadings through constructing a nanocage structure and concentrating high-density accessible binary single-atomic Fe/Co–Nx sites in a porous shell. The prepared FeCo-NCH features metal loading with a single-atomic distribution as high as 7.9 wt% and an accessible site density of around 7.6 × 1019 sites g−1, surpassing most reported M–Nx catalysts. In anion exchange membrane fuel cells and zinc–air batteries, the FeCo-NCH material delivers peak power densities of 569.0 or 414.5 mW cm−2, 3.4 or 2.8 times higher than control devices assembled with FeCo-NC. These results suggest that the present strategy for promoting catalytic site utilization offers new possibilities for exploring efficient low-cost electrocatalysts to boost the performance of various energy devices.

The rational design of integrated electrodes and the strategies for improving their performances are reviewed to advance high-rate alkaline water electrolysis. Such electrodes could be extended for other emerging electrocatalytic hydrogen production systems.

The accumulation of gluons inside nucleons, i.e., the gluon condensation, may lead to a characteristic broken power-law gamma-ray spectrum in high-energy nucleon collisions. Here we show that the observed spectra of at least 25 sources in the second Fermi Large Area Telescope Catalog of Gamma-ray Pulsars can be well fitted by such a broken power-law function that has only four free parameters. It strongly indicates that the gamma-ray emission from these pulsars is of hadronic origin, but with gluon condensation inside hadrons. It is well known that the quark-gluon distribution in a free nucleon is different from that in a bound nucleon. This work exposes the nuclear $A$ dependence of the gluon condensation effect, where $A$ refers to the baryon number. Our study reveals the gluon condensation under the condition of $A\to\infty$, which may open a new window for eavesdropping on the structure of compact stars on the subnuclear level., 10 pages, 5 figures, 1 table, typos fixed

Within the framework of quantum statistical mechanics, we have proposed an exact analytical solution to the problem of Bose-Einstein condensation (BEC) of harmonically trapped, two-dimensional, and ideal photons. We utilize this analytical solution to investigate the statistical properties of ideal photons in a two-dimensional dye-filled spherical cap cavity. The results of numerical calculation of the analytical solution agree completely with the foregoing experimental results in the BEC of harmonically trapped, two-dimensional, and ideal photons. The analytical expressions of the critical temperature and the condensate fraction are derived in the thermodynamic limit. It is found that the two-dimensional critical photon number is larger than the one-dimensional critical photon number by two orders of magnitude. The spectral radiance of a two-dimensional spherical cap cavity has a sharp peak at the frequency of the cavity cutoff when the photon number exceeds the critical value determined by a temperature. PACS numbers: 42.50.-p, 03.75.Hh, 67.85.Hj