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Islam is a da’wah religoin that assigns its people to broadcast its teachings to all mankind as rahmatan lil’alamin. Islam guarantees the realization of happiness and prosperty when its teachings become a way og life and implement it consistently and consistently. Today we are faced with the rapid development of the times. The influence og globalization makes the islamic generation drift away in an instant which results in a slow decline so that the Islamic identity and character of Muslims is lost. This makes a Muslim weak and powerless. The author conducted this study aimed at: Knowing the SSG Training program, Knowing the da’wah method used by the SSG Training Program, and knowing yhe supporting and inhibiting factors of the SSG Training Program. This research is a qialitative research with a case study approach. Data collection techniques in the form of interview text, observation, documentation. The object of this research is the Ready-to-Use Santri Training Program which has the aim of creating students with Good and Strong characters and can play a role in the mindst of state and religious problems as agents of change. In building good and strong characters, there are three stages of the program, namely the self destruct stage program, the self building stage of the program, and the team building stage program. The results of the research are the Ready to Use Santri Training program using the Bil Lisan, Bil Hikmah, Bil Al-Mau’izhah Al-Hasanah, and Bil Al-Mujlah Bi-al-Lati Hiya Ahsan da’wah methods. Supporting factors: discipline, da’wah methods, individual students. Inhibiting factors: individual student, environmental factors, and ineffective communication. Abstrak. Islam adalah agama dakwah yang menugaskan umatnya untuk menyiarkan ajarannya kepada seluruh umat manusia sebagai rahmatan lil’alamin. Islam menjamin terwujudnya kebahagiaan dan kesejahteraan manakala ajarannya menjadi pedoman hidup dan melaksanakan secara konsisten serta konsekuen. Dewasa ini kita dihadapkan dengan perkembangan zaman yang cepat. Pengaruh globalisasi menjadikan generasi Islam ikut hanyut dalam keinstanan yang mengakibatkan kemunduran dengan perlahan sehingga hilanglah jati diri dan akhlak Islami muslim. Hal ini menjadikan seorang muslim lemah dan tidak memiliki kekuatan. Penulis melakukan penelitian ini bertujuan untuk: Mengetahui program Diklat SSG, Mengetahui Metode dakwah yang digunakan Program Diklat SSG, dan mengetahui faktor pendukung dan penghambat Program Diklat SSG. Penelitian ini merupakan penelitian kualitiatif dengan pendekatan studi kasus. Teknik pengumpulan data berupa teks wawancara, observasi, dokumentasi. Objek penelitian ini adalah Program Diklat Santri Siap Guna yang memiliki tujuan terciptanya santri berkarakter Baik dan Kuat dan dapat berperan di tengah-tengah permasalahan negara dan agama sebagai agen perubahan. Dalam pembinaan karakter baik dan kuat memiliki tiga tahapan program yaitu program tahap dobrak diri, program tahap bangun diri, dan program tahap bangun tim. Hasil dari penelitian yaitu program Diklat Santri Siap Guna menggunakan metode dakwah Bil Lisan, Bil Hikmah, Bil Al-Mau’izhah Al-Hasanah, dan Bil Al-Mujadalah Bi-al-Lati Hiya Ahsan. Faktor pendukung: Tata tertib, metode dakwah, individu santri. Faktor penghambat: Individu santri, faktor lingkungan, dan komunikasi tidak efektif.

Film is an important medium’s of da’wah, because it is an audio-visual media that can be enjoyed anywhere and anytime. The animated film Nussa and Rarra episode Nussa can tell the story of Nussa's desire to participate in a football match despite her physical limitations. The purpose of this research is to find out the message of aqidah, shari'ah and morals da'wah contained in the film. This study uses a qualitative type with semiotic analysis method Roland Barthes model by examining the signs and markers in the film. The results of the study showed several da'wah messages including: aqidah; Allah does not look at the physical but the heart, accepts everything sincerely. Shari'ah; obligation to wear hijab, start activities with basmallah. Morals; kissing parents' hands, caring for sick parents, knocking on doors before entering, speaking kind words to parents. Abstrak. Film adalah media dakwah yang penting, sebab ia merupakan media audio-visual yang dapat dinikmati dimana saja dan kapan saja. Film animasi Nussa dan Rarra episode Nussa bisa mengisahkan tentang keinginan Nussa untuk mengikuti pertandingan sepak bola walapun dengan keterbatasan fisik yang dimilikinya. Tujuan dari penelitian ini untuk mengetahui pesan dakwah aqidah, syari’ah dan akhlak yang terkandung dalam film tersebut. Penelitian ini menggunakan jenis kualitatif dengan metode anlisis semiotika model Roland Barthes dengan mengkaji tanda dan petanda dalam film tersebut. Hasil penelitian menunjukkan beberapa pesan dakwah diantaranya: aqidah; Allah tidak memandang fisik melainkan hati, menerima segala sesuatu dengan ikhlas. Syari’ah; kewajiban berhijab, memulai aktifitas dengan basmallah. Akhlak; mencium tangan orangtua, merawat orangtua yang sakit, mengetuk pintu sebelum memasukinya, bertutur kata baik kepada orangtua.

The transforming growth factor-β (TGF-β) family of cytokines performs a multifunctional signaling, which is integrated and coordinated in a signaling network that involves other pathways, such as Wintless, Forkhead box-O (FOXO) and Hedgehog and regulates pivotal functions related to cell fate in all tissues. In the hematopoietic system, TGF-β signaling controls a wide spectrum of biological processes, from immune system homeostasis to the quiescence and self-renewal of hematopoietic stem cells (HSCs). Recently an important role in post-transcription regulation has been attributed to two type of ncRNAs: microRNAs and pseudogenes. Ciona robusta, due to its philogenetic position close to vertebrates, is an excellent model to investigate mechanisms of post-transcriptional regulation evolutionarily highly conserved in immune homeostasis. The combined use of NGS and bioinformatic analyses suggests that in the pharynx, the hematopoietic organ of Ciona robusta, the Tgf-β, Wnt, Hedgehog and FoxO pathways are involved in tissue homeostasis, as they are in human. Furthermore, ceRNA network interactions and 3′UTR elements analyses of Tgf-β, Wnt, Hedgehog and FoxO pathways genes suggest that different miRNAs conserved (cin-let-7d, cin-mir-92c, cin-mir-153), species-specific (cin-mir-4187, cin-mir-4011a, cin-mir-4056, cin-mir-4150, cin-mir-4189, cin-mir-4053, cin-mir-4016, cin-mir-4075), pseudogenes (ENSCING00000011392, ENSCING00000018651, ENSCING00000007698) and mRNA 3′UTR elements are involved in post-transcriptional regulation in an integrated way in C. robusta.

Background Dermal scaffolds for tissue regeneration are nowadays an effective alternative in not only wound healing surgeries but also breast reconstruction, abdominal wall reconstruction and tendon reinforcement. The present study describes the development of a decellularization protocol applied to human split-thickness skin from cadaveric donors to obtain dermal matrix using an easy and quick procedure. Methods Complete split-thickness donor was decellularized through the combination of hypertonic and enzymatic methods. To evaluate the absence of epidermis and dermal cells, and ensure the integrity of the extracellular matrix (ECM) structure, histological analysis was performed. Residual genetic content and ECM biomolecules (collagen, elastin, and glycosaminoglycan) were quantified and tensile strength was tested to measure the effect of the decellularization technique on the mechanical properties of the tissue. Results Biomolecules quantification, residual genetic content (below 50 ng/mg dry tissue) and histological structure assessment showed the efficacy of the decellularization process and the preservation of the ECM. The biomechanical tests confirmed the preservation of native properties in the acellular tissue. Conclusions The acellular dermal matrix obtained from whole split-thickness skin donor with the newly developed decellualrization protocol, maintains the desired biomechanical and structural properties and represents a viable treatment option for patients.

The 5' and 3' RACE is a method to obtain full-length 5' and 3' ends of cDNA using known cDNA sequences from expressed sequence tags (ESTs), subtracted cDNA, differential display, or library screening. Here is described the identification of full-length 5' and 3' ends of Ciona robusta Mif1 and Mif2 cDNA by using 5' and 3' RACE method.

Neural models for text generation are often designed in an end-to-end fashion, typically with zero control over intermediate computations, limiting their practical usability in downstream applications. In this work, we incorporate explicit means into neural models to ensure topical continuity, informativeness and content diversity of generated radiology reports. For the purpose we propose a method to compute image representations specific to each sentential context and eliminate redundant content by exploiting diverse sentence states. We conduct experiments to generate radiology reports from medical images of chest x-rays using MIMIC-CXR. Our model outperforms baselines by up to 18% and 29% respective in the evaluation for informativeness and content ordering respectively, relative on objective metrics and 16% on human evaluation.

From an environmental and economic viewpoint, it is a win-win strategy to use materials obtained from renewable resources for the production of high-performance elastomer composites. Lignin, being a renewable biomass, was employed as a functional filler material to obtain an elastomer composite with a higher degree of mechanical performance. In the presence of a suitable coupling agent, an elevated temperature was preferred for the reactive mixing of lignin with polybutadiene rubber (BR). It is quite fascinating that the mechanical performance of this composite was comparable with carbon black-filled composites. The extraordinary reinforcing behavior of lignin in the BR matrix was understood by an available model of rubber reinforcement. In rubber composite preparation, the interfacial interaction between polybutadiene rubber and lignin in the presence of a coupling agent enabled the efficient dispersion of lignin into the rubber matrix, which is responsible for the excellent mechanical properties of the rubber composites. The rubber composites thus obtained may lead to the development of a sustainable and cost-effective end product with reliable performance. This novel approach could be implemented in other type of elastomeric materials, enabling a genuine pathway toward a sustainable globe. publishedVersion

Parathyroidectomy is a standard practice to treat recurrent or persistent hyperparathyroidism. However, this can lead to the onset of hypoparathyroidism, treatable with the autotransplantation of parathyroid tissue (PT). Tissue can be transplanted immediately after parathyroidectomy or cryopreserved and transplanted only in case of necessity. Since 2011, the Cord Blood Bank and Cardiovascular Tissue Bank of Emilia-Romagna has been storing PT for potential autologous transplantation. To date, there are highly variable data about the viability and function of PT after thawing. However, it is not clear if the PT quality is affected by different cryopreservation protocols and/or by the storage time. The aim of this study was to assess the ex vivo function and viability of the PTs of ten patients stored in the Bank. Tissue morphology was evaluated before and after cryopreservation through histological investigations. PT function was analyzed by assessing the ability of cryopreserved PT to synthesize and secrete parathyroid hormone (PTH) in response to different calcium concentrations. Moreover, viability and function were also investigated on tissue-isolated cells in culture. These data show that tested tissues appear to be viable and able to produce PTH even after 5 years of storage, and the histological architecture is well preserved.

Matrix metalloproteinases (MMPs) are a family of endopeptidases collectively able to degrade the components of the extracellular matrix (ECM), with important roles in many biological processes, such as embryogenesis, normal tissue remodelling, angiogenesis and wound healing. New views on the function of MMPs reveal that they regulate inflammatory response and therefore might represent an early step in the evolution of the immune system. MMPs can affect the activity of cytokines involved in inflammation including TGF-β and TNF-α. MMPs are widely distributed in all kingdoms of life and have likely evolved from a single-domain protein which underwent successive rounds of duplications. In this study, we focused on the Ciona robusta (formerly known as Ciona intestinalis) MMP gelatinase homologue. Gene organization, phylogenetic analysis and 3D modeling supported the closest correlation of C. robusta gelatinase with the human MMP-9. Real-time PCR analysis and zymographic assay showed a prompt expression induced by LPS inoculation and an upregulation of enzymatic activity. Furthermore, we showed that before of the well-known increase of TGF-β and TNF-α levels, a MMP- 9like boost occurred, suggesting a possible involvement of MMP-9like in regulating inflammatory response in C. robusta.