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102. Clinical and histopathological profile of oral cancer: a quadrennial analysis of Regional Cancer Centre of Odisha, India.

Author

PANDA, S., PANDA, SAS., MOHANTY, N., GIACOMELLO, M., COLLETTI, L., CORRADINI, C., LUCCHINA, A. GRECO, GOKER, F., MORTELLARO, C., DEL FABBRO, M., and PANDA, SAU.

Abstract

OBJECTIVE: To contribute toward the identification of population-based clinical and histopathological profile of oral squamous cell carcinoma (OSCC), this study was undertaken at the Regional Cancer Centre of Odisha (AHRCC), India. PATIENTS AND METHODS: This retrospective study included all patients diagnosed with OSCC registered at AHRCC, Odisha from 1st January 2015 to 31st December 2018. Demographic, clinical, and pathological data of each patient were retrieved from patient records. Patients with incomplete records were excluded. No postoperative treatment details were collected. RESULTS: The study included 851 cases of OSCC with the mean age of the population found to be 53.8±14.2 years. Male to female ratio was found to be 2.18:1. Gingivobuccal complex was the most common site of OSCC. While 679 patients were reported to undergo incision biopsy only 172 patients underwent excision biopsy in four years. Well differentiation (n=782) is the most common histological grading. The median clinical size of the tumour was 4 cm. Upon analyzing histological parameters in excision specimens lymphovascular and perineural invasion were seen in 38 and 26 cases, respectively. Cervical lymph node metastasis was seen in 42 cases out of 172 excision specimens (24%). 63.23% of cases presented with a depth of invasion between 5 to 10 mm. CONCLUSIONS: This is the largest comprehensive data from the regional cancer center of Odisha population which highlights the demographic, clinical, and histopathological data reported to date. [ABSTRACT FROM AUTHOR]

Published
2023

103. Optical coherence tomography application for assessing variation in bone mineral content: a preclinical study.

Author

KHIJMATGAR, S., PANDA, S., BIAGI, R., ROVATI, M., COLLETTI, L., GOKER, F., LUCCHINA, A. GRECO, MORTELLARO, C., and DEL FABBRO, M.

Abstract

OBJECTIVE: Optical Coherence Tomography (OCT) is a non-invasive imaging technique that produces cross-sectional images through biological tissues, allowing three-dimensional reconstruction and analysis. Aim was to evaluate if OCT may discriminate among tissues with different bone density and composition, by measuring the depth of light penetration in porcine and rat bone samples. MATERIALS AND METHODS: Two carpal bone samples (2 cm length) were harvested from the porcine forelimb and fixed overnight in 3.7% buffered formal saline. Following fixation, one sample was decalcified in a 1:1 mixture of 8% hydrochloric acid and 8% formic acid solution for three days, with solution changes each day. Samples were imaged using an OCT microscope. Furthermore, the calvaria, ulnar, alveolar and basal bone of mandible of 6 male and 6 female rats were cleared of overlying soft tissues and scanned under OCT. The light penetration depth in each sample was measured using the software Image J, and Scattering Attenuation Microscopy. RESULTS: In the mineralized bone the average depth (µm) and standard deviation (SD) of light penetration were 790.1±18.05 and 410.4±21.7 for periosteal and endosteal surface, respectively, and 507.3±21.03 for cross-section surfaces, while it was 858.4±32.03 for periosteal surface, 1150±26.9 for endosteal, and 627.3±31.8 for cross-section bone surfaces in demineralized porcine bone. There was a significant difference (p<0.001) in depth of light penetration between normal and de-mineralized bone for all regions evaluated. No systematic significant difference in light penetration depth between-gender was found at any site evaluated, while there were variations between sites (p<0.001). The OCT detected differences in bone mineral and porosity among gender (p<0.0001) CONCLUSIONS: This study suggests that OCT may represent a valuable technique to estimate local variations in bone mineral content. [ABSTRACT FROM AUTHOR]

Published
2023

104. Efficacy and safety of pangenotypic DAAs for chronic HCV infection: real-world data from the RESIST-HCV cohort

Author

Salomone, F., primary, Cacciola, I., additional, Petta, S., additional, Calvaruso, V., additional, Micek, A., additional, Madonia, S., additional, Grova, M., additional, Distefano, M., additional, Cannavò, M., additional, Di Rosolini, M.A., additional, Digiacomo, A., additional, Di Lorenzo, F., additional, Bertino, G., additional, Licata, A., additional, Latteri, F., additional, Benanti, F., additional, Averna, A., additional, Guarneri, L., additional, Scalisi, I., additional, Iacobello, C., additional, Montineri, A., additional, Colletti, P., additional, Cartabellotta, F., additional, Davì, A., additional, Russello, M., additional, Scifo, G., additional, Squadrito, G., additional, Raimondo, G., additional, Craxì, A., additional, and Di Marco, V., additional

Published
2022
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114. Artificial intelligence for the differentiation between multiple sclerosis and glioma II° or III° using 18F-FET-PET imaging

Author

Rauschenbach, L, Kebir, S, Weber, M, Lazaridis, L, Schmidt, T, Keyvani, K, Schäfer, N, Umutlu, L, Pierscianek, D, Stuschke, M, Forsting, M, Sure, U, Kleinschnitz, C, Antoch, G, Colletti, P, Rubello, D, Herrmann, K, Herrlinger, U, Scheffler, B, Bundschuh, R, and Glas, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: To evaluate the diagnostic significance of 18F-FET-PET imaging for the differentiation between multiple sclerosis (MS) and World Health Organization (WHO) grade 2/3 glioma (glioma II°/III°). Methods: We retrospectively screened for patients in whom 18F-FET-PET imaging[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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117. Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) outbreaks in nursing homes involving residents who had completed a primary coronavirus disease 2019 (COVID-19) vaccine series—13 US jurisdictions, July–November 2021

Author

Wyatt Wilson, W., Keaton, Amelia A., Ochoa, Lucas G., Hatfield, Kelly M., Gable, Paige, Walblay, Kelly A., Teran, Richard A., Shea, Meghan, Khan, Urooj, Stringer, Ginger, Colletti, Joanne G., Grogan, Erin M., Calabrese, Carly, Hennenfent, Andrew, Perlmutter, Rebecca, Janiszewski, Katherine A., Kamal-Ahmed, Ishrat, Strand, Kyle, Berns, Emily, MacFarquhar, Jennifer, Linder, Meghan, Tran, Dat J., Kopp, Patricia, Walker, Rebecca M., Ess, Rebekah, Read, Jennifer S., Yingst, Chelsey, Baggs, James, Jernigan, John A., Kallen, Alex, and Hunter, Jennifer C.

Abstract

AbstractAmong nursing home outbreaks of coronavirus disease 2019 (COVID-19) with ≥3 breakthrough infections when the predominant severe acute respiratory coronavirus virus 2 (SARS-CoV-2) variant circulating was the SARS-CoV-2 δ (delta) variant, fully vaccinated residents were 28% less likely to be infected than were unvaccinated residents. Once infected, they had approximately half the risk for all-cause hospitalization and all-cause death compared with unvaccinated infected residents.

Published
2023
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118. Use, Durability, and Risks for Discontinuation of Initial and Subsequent Biologics in a Large Pediatric-Onset IBD Cohort

Author

Kaplan, Jess L., Liu, Chunyan, King, Eileen C., Bass, Julie A., Patel, Ashish S., Tung, Jeanne, Chen, Shiran, Lissoos, Trevor, Candela, Ninfa, Saeed, Shehzad, Colletti, Richard B., Adler, Jeremy, Baron, Howard I., Cabrera, José M., Dorsey, Jill M., Dykes, Dana M.H., Ebach, Dawn R., Garin-Laflam, Monica P., Gold, Benjamin D., Grunow, John, Higuchi, Leslie M., Jester, Traci W., Lapsia, Sameer P., Leibowitz, Ian, Linvlle, Tiffany M., Morhardt, Tina L., Moses, Jonathan, Moulton, Dedrick, Nasiri-Blomgren, Shaida, Niklinska-Schirtz, B. Joanna, Ogunmola, Nicholas A., Palomo, Pablo J., Park, K.T., Pashankar, Dinesh S., Pasternak, Brad A., Radano, Marcella C., Samson, Charles M., Sandberg, Kelly C., Schaefer, Marc E., Shashidhar, Harohalli, Steiner, Steven J., Sullivan, Jillian S., Tomer, Gitit, and Verstraete, Sophia G.

Published
2023
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119. 3rd IANA (International Academy on Nutrition and Aging) Meeting Nutrition, Exercise & Alzheimer and Clinical Trials on Sarcopenia August 1–2, 2008 Hyatt Regency Tamaya Resort 1300 Tuyuna Trail Santa Ana Pueblo, NM USA

Author

Andrieu, S., Barberger-Gateau, P., Raffaitin, C., Berr, C., Tzourio, C., Dartigues, J. -F., Gin, H., Fitten, L. J., Ortiz, F., Fairbanks, L., Bartzokis, G., Lu, P., Ringman, J., Heyn, P. C., Locher, J. L., Salvà, A., Andrieu, S., Fernández, E., Vellas, B., van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Beekman, A. T. F., Hoefnagels, W. H. L., de Groot, C. P. G. M., Angevaren, M., Aufdemkampe, G., Verhaar, H. J. J., Aleman, A., Vannees, L., Arkin, S., Florez, H., Gerstein, H., Sheridan, P., Bosch, J., Goldberg, R., Kaspar, K. M., Drawert, S. M., Marcus, R. L., Kidde, J., Dibble, L., Addison, O., LaStayo, P. C., Scarmeas, N., Stern, Y., Schupf, N., Luchsinger, J. A., Sharkey, J. R., Laditka, J. N., Laditka, S. B., Liu, R., Hochhalter, A., Robare, J. F., Türner, N., Judge, M., Foster, T. C., Erdos, B., Cudykier, I., Scarpace, P. J., Weiss, L. A., Bergstrom, J., Kritz-Silverstein, D., Barrett-Connor, Elizabeth, Yurko-Mauro, K., Nelson, E., Quinn, J., Sattler, F. R., Castaneda-Sceppa, C., Binder, E. F., Schroeder, E. T., Wang, Y., Bhasin, S., Kawakubo, M., Stewart, Y., Hahn, C., Colletti, P., Roubenoff, R., Yarasheski, K. E., Azen, S. P., Aoki, Y., Yamamoto, T., Otuka, T., Blanc-Bisson, C., Bourdel-Marchasson, I., Bocock, M. A., Keller, H. H., Bowman, G., Baxter, J., Oken, B., Frei, B., Traber, M., Leonard, S., Kaye, J., Shannon, J., Quinn, J., Carlsson, M., Gustafson, Y., Eriksson, S., Littbrand, H., Håglin, L., Danthiir, V., Wilson, C., Nettelbeck, T., Burns, N., Wittert, G., Noakes, M., Clifton, P., DiMaria-Ghalili, R. A., Grieger, J. A., Nowson, C. A., Wattanapenpaiboon, N. T., Holstein, J., Robinson, C., Hartmann, C., Rueb, S., Heffel, L., Dintaman, S., Reynolds, J., Fleming, L., Crull, M., Goldey, J., Serper, L. L., Hubbard, R., Westengard, J., Horning, M., Ishige, Y., Aoki, Y., Keller, H. H., Keller, H. H., LaStayo, P. C., Marcus, R. L., Smith, S., Kidde, J., Dibble, L., Butler, C., Hill, M., LaStayo, P. C., Marcus, R. L., Dibble, L., Kidde, J., Peters, C., Meier, W., Laughlin, G. A., Kritz-Silverstein, D., von Muhlen, D., Barrett-Connor, E., Olariu, L., Petcu, M., Tulcan, C., Pup, M., Otilingam, P., Gate, M., Pasinetti, G. M., Ray, B., Chauhan, N. B., Bailey, J. A., Lahiri, D. K., Shatenstein, B., Kergoat, M. -J., Reid, I., Chicoine, M. -E., Vaz, L., Stewart, R., Sabbah, W., Tsakos, G., D’Aiuto, F., Watt, R. G., Sturman, M., Kelly, J., Fleischman, D., Leurgans, S., Bennett, D., Morris, M. C., Suominen, M. H., Muurinen, S., Soini, H., Pitkälä, K. H., Yamamoto, T., Fujinoki, C., and Aoki, Y.

Published
2008
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120. Perceptions of U = U Among Italian Infectious Diseases Specialists: A Nationwide Survey on Providers' Attitudes Toward the Risk of HIV Transmission in Virologically Suppressed Patients.

Author

Ripamonti, Diego, Poliseno, Mariacristina, Mazzola, Giovanni, Colletti, Pietro, Di Biagio, Antonio, Celesia, Benedetto Maurizio, Gori, Andrea, Bellagamba, Rita, Madeddu, Giordano, Nozza, Silvia, Rusconi, Stefano, Cascio, Antonio, and Lo Caputo, Sergio

Abstract

This survey aimed to understand how far the Italian infectious diseases (ID) specialists are confident in the "Undetectable = Untransmittable" (U = U) message and translate this concept into clinical practice. An anonymous survey was distributed by e-mail to 286 clinicians to collect their opinions regarding six situations potentially at risk of HIV transmission between virologically suppressed patients and seronegative individuals who possibly require postexposure prophylaxis (PEP). Overall, 51% of ID specialists deemed zero risk of HIV transmission through condomless sex for undetectable patients. This answer was more frequent among HIV specialists (30% vs. 21%, p = .01) and clinicians working in teaching hospitals (35% vs. 16%, p = .03). Remarkably, 61% of participants would advise taking PEP for the HIV-negative partner in case of sexual intercourse with a seropositive person with a recent blip occurrence or absence of an HIV RNA test performed within the last 6 months (63%). Seventy-three percent of respondents deemed it essential to know patients' history of adherence to interpreting an HIV RNA test, regardless of its timing. When applying the U = U concept to daily clinical decisions, we observed an overall cautious attitude among physicians. Concerns mainly regarded the timing of the last HIV RNA test to the exposure event, especially in the absence of details on the patient's adherence. Wider diffusion and application of the U = U message are needed. [ABSTRACT FROM AUTHOR]

Published
2022
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121. Bionic ear imaging

Author

Cerini, R., Faccioli, N., Barillari, M., De Iorio, M., Carner, M., Colletti, V., and Pozzi Mucelli, R.

Published
2008
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139. Call to action: empowering patients and families to initiate clinical ethics consultations

Author

Blackler, Liz, Scharf, Amy E, Matsoukas, Konstantina, Colletti, Michelle, and Voigt, Louis P

Abstract

Clinical ethics consultations exist to support patients, families and clinicians who are facing ethical or moral challenges related to patient care. They provide a forum for open communication, where all stakeholders are encouraged to express their concerns and articulate their viewpoints. Ethics consultations can be requested by patients, caregivers or members of a patient’s clinical or supportive team. Although patientsand by extension their families (especially in cases of decisional incapacity) are the common denominators in most ethics consultations, these constituents are the leastlikely to request them. At many healthcare organisations in the USA, ethics consultations are overwhelmingly requested by physicians and other clinicians. We believe it is vital that healthcare institutions bridge the knowledge gaps and power imbalances over access to ethics consultation services through augmented policies, procedures and infrastructure. With enhanced education and support, patients and families may use ethics consultation to elevate their voices and prioritise their unique characteristics and preferences in the delivery of their healthcare. Empowering patients and families to request ethics consultation can only strengthen the patient/family–clinician relationship, enhance the shared decision-making model of care and ultimately lead to improved patient-centred care.

Published
2023
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144. Cross-correlation technique to identify activated pixels in a three-condition fMRI task

Author

Singh, M., Al-Dayeh, L., Jeong, J., Kim, T., and Colletti, P.

Subjects
Magnetic resonance imaging -- Research, Pixels -- Identification and classification, Business, Electronics, Electronics and electrical industries
Abstract

Most fMRI studies are conducted with a stimulus 'on' and a stimulus 'off' or control state to delineate pixels activated during a two-condition presentation. We have developed a multiple reference function based novel cross-correlation technique that is not restricted to two conditions but could be applied to delineate pixels activated in multi-condition tasks. A logic-based analysis to form functional images, where each pixel is uniquely assigned to an image based on which reference function produced the highest correlation-coefficient for that pixel, has also been developed. Both steady-state and event-related fMRI studies have been conducted. Using steady-state motor stimulation as an example with right and left hand movements representing conditions 1 and 2, and no movement representing condition 3, results of images generated through a three-condition processing technique are in good agreement with those generated through two separate two-condition experiments. Similarly, the results of right and left finger flexions in a multicondition event-related study show that the logic based correlation coefficient approach provides unique information about the activation characteristics of individual pixels.

Published
1999

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