Search

Your search keyword '"Derendorf, Hartmut"' showing total 1,299 results
Start Over Author "Derendorf, Hartmut"
1,299 results on '"Derendorf, Hartmut"'

105. Pharmacokinetic and pharmacodynamic properties of inhaled ciclesonide

Author

Derendorf, Hartmut

Subjects
Corticosteroids -- Dosage and administration -- Properties, Asthma -- Drug therapy, Health, Drug therapy, Properties, Dosage and administration
Abstract

Inhaled corticosteroids are recommended first-line therapy for persistent asthma of all severities; however, oropharyngeal and systemic adverse events can be a concern. Inhaled corticosteroids exert their therapeutic and adverse effects [...]

Published
2007

106. Effect of simulated microgravity on the disposition and tissue penetration of ciprofloxacin in healthy volunteers

Author

Schuck, Edgar L., Grant, Maria, and Derendorf, Hartmut

Subjects
Pharmacokinetics -- Research -- Health aspects, Microgravity -- Research -- Health aspects, Ciprofloxacin -- Health aspects -- Research, Health, Research, Health aspects
Abstract

This study evaluated the effects of simulated microgravity (sμG) on the pharmacokinetics of ciprofloxacin. Six healthy volunteers participated in a crossover study to compare the pharmacokinetics of ciprofloxacin after a [...]

Published
2005

107. Dipyridamole bioavailability in subjects with reduced gastric acidity

Author

Derendorf, Hartmut, VanderMaelen, Cam P., Brickl, Rolf-Stefan, MacGregor, Tom R., and Eisert, Wolfgang

Subjects
Aged -- Health aspects -- Research, Stroke (Disease) -- Prevention -- Drug therapy -- Research, Gastric acid -- Drug therapy -- Research -- Health aspects, Dipyridamole -- Dosage and administration -- Research, Health, Drug therapy, Prevention, Research, Dosage and administration, Health aspects
Abstract

Dipyridamole (DP) is an antiplatelet agent that shows decreased oral bioavailability with increased gastric pH that occurs with commonly prescribed antacids. An extended-release (ER) formulation of DP that employs tartaric [...]

Published
2005

108. Penetration of ertapenem into different pulmonary compartments of patients undergoing lung surgery

Author

Burkhardt, Olaf, Majcher-Peszynska, Jolanta, Borner, Klaus, Mundkowski, Ralf, Drewelow, Bernd, Derendorf, Hartmut, and Welte, Tobias

Subjects
Ertapenem (Medication) -- Dosage and administration -- Complications and side effects -- Licensing, certification and accreditation, Bacterial pneumonia -- Drug therapy -- Complications and side effects -- Research, Pharmacokinetics -- Research, Pneumonia -- Drug therapy -- Complications and side effects -- Research, Epithelial cells -- Research, Health, Drug therapy, Complications and side effects, Research, Licensing, certification and accreditation, Dosage and administration
Abstract

Ertapenem is approved for the treatment of community-acquired pneumonia (CAP), but its in vivo penetration into lung tissue (LT), epithelial lining fluid (ELF), and alveolar cells (AC) is unknown. Fifteen [...]

Published
2005

109. Population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction

Author

Bhattaram, Venkatesh Atul, Nagaraja, Nelamangala V., Peters, Tanja, Machnig, Thomas, Kroesser, Sonja, Kovar, Andreas, and Derendorf, Hartmut

Subjects
Heart attack -- Drug therapy -- Research, Pharmacokinetics -- Research, Serotonin uptake inhibitors -- Research, Health, Drug therapy, Research
Abstract

Eniporide (EMD 96 875) is a novel and selective inhibitor of the [Na.sup.+]-[H.sup.+] exchange (NHE-1) inhibitor. The study objectives were to identify a structural model for population pharmacokinetic analysis of [...]

Published
2005

110. Tissue penetration of cefpodoxime and cefixime in healthy subjects

Author

Liu, Ping, Muller, Markus, Grant, Maria, Obermann, Bernd, and Derendorf, Hartmut

Subjects
Pharmacokinetics -- Research, Drug targeting -- Testing -- Research, Cefixime -- Evaluation -- Research, Cefpodoxime -- Evaluation -- Research, Health, Testing, Evaluation, Research
Abstract

Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, [...]

Published
2005

122. Plasma l‐indospicine and 3‐nitropropionic acid in ponies fed creeping indigo: Comparison with results from an episode of presumptive creeping indigo toxicosis.

Author

Darby, Shannon, Sanchez, L. Chris, Mallicote, Martha F., House, Amanda M., Plummer, Caryn E., Nadruz, Veridiana, Benmoha, Rachel H., Roberts, Stephen M., Derendorf, Hartmut, Silva‐Sanchez, Cecilia, Claire, Jami, and MacKay, Robert J.

Abstract

Background: Creeping indigo (Indigofera spicata) toxicosis is an emerging problem among horses in Florida and bordering states. Objectives: To quantify the putative toxins l‐indospicine (IND) and 3‐nitropropionic acid (NPA) in creeping indigo collected from multiple sites and to measure plasma toxin concentrations in ponies fed creeping indigo and horses with presumptive creeping indigo toxicosis. Study design: Experimental descriptive study with descriptive observational field investigation. Methods: Air‐dried creeping indigo was assayed for IND and NPA content. Five ponies were fed chopped creeping indigo containing 1 mg/kg/day of IND and trace amounts of NPA for 5 days, then observed for 28 days. Blood samples from these ponies and from horses involved in a presumptive creeping indigo toxicosis were assayed for IND and NPA. Results: IND in creeping indigo plants was 0.4‐3.5 mg/g dry matter whereas NPA was <0.01 to 0.03 mg/g. During creeping indigo feeding, clinical and laboratory signs were unchanged except for significant weight loss (median 6%, range 2%‐9%; p =.04) and significant increase from baseline plasma protein concentration (median 16 g/L, range 8‐25 g/L; p <.001). These changes could not definitively be ascribed to creeping indigo ingestion. Plasma IND rose to 3.9 ± 0.52 mg/L on day 6. Pharmacokinetic modelling indicated an elimination half‐life of 25 days and a steady state plasma concentration of 22 mg/L. Plasma IND concentration in sick horses during an incident of creeping indigo toxicosis was approximately twice that of clinically normal pasture mates. Plasma NPA was <0.05 mg/L in all samples. Main limitations: Creeping indigo used in the feeding trial may not be representative of plants involved in creeping indigo toxicosis. There was no control group without creeping indigo in the feeding trial. Conclusions: Indospicine can be detected in blood of horses consuming creeping indigo and the toxin accumulates in tissues and clears slowly. The role of NPA in the neurological signs of this syndrome is unclear. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

133. Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for leishmaniasis treatment

Author

Galvão, Juliana G., primary, Santos, Raquel L., additional, Silva, Audrey R.S.T., additional, Santos, Jeferson S., additional, Costa, Amanda M.B., additional, Chandasana, Hardik, additional, Andrade-Neto, Valter V., additional, Torres-Santos, Eduardo Caio, additional, Lira, Ana Amélia M., additional, Dolabella, Silvio, additional, Scher, Ricardo, additional, Kima, Peter E., additional, Derendorf, Hartmut, additional, and Nunes, Rogéria S., additional

Published
2020
Full Text
View/download PDF

134. Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein

Author

do Nascimento, Sara Batista, primary, de Lima Nascimento, Mariana, additional, de Araújo, Laís Lobato, additional, de Oliveira, Flávio Martins, additional, do Carmo Vieira, Maria, additional, Duarte-Almeida, Joaquim Maurício, additional, Siqueira, João Máximo, additional, da Costa César, Isabela, additional, Derendorf, Hartmut, additional, and de Castro, Whocely Victor, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results