101. Association between urine lead levels and cardiovascular disease risk factors, carotid intima-media thickness and metabolic syndrome in adolescents and young adults
- Author
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Chien-Yu Lin, Fung-Chang Sung, Ta-Chen Su, Po-Chin Huang, and Charlene Wu
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,010501 environmental sciences ,Carotid Intima-Media Thickness ,01 natural sciences ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Risk Factors ,Internal medicine ,medicine ,Humans ,Glucose homeostasis ,cardiovascular diseases ,030212 general & internal medicine ,Risk factor ,0105 earth and related environmental sciences ,Metabolic Syndrome ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,medicine.disease ,Blood pressure ,Lead ,Intima-media thickness ,Cardiovascular Diseases ,Cohort ,Environmental Pollutants ,Female ,Metabolic syndrome ,business ,Body mass index - Abstract
Background Environmental lead exposure is a known risk factor of cardiovascular disease (CVD) in animal and human epidemiological studies of adults, but limited research has been conducted in young populations. Moreover, the association between lead level and common carotid artery intima-media thickness (CIMT) has never been documented. Design and Participants: In this study, 738 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between lead levels in urine and CVD risk factors, metabolic syndrome (MS) and CIMT. Results The geometric mean of the urine lead level was 1.50 μg/g creatinine. We found a significant positive association between urine lead levels and CVD risk factors, including diastolic blood pressure (DBP), mean arterial pressure (MAP), as well as markers of glucose homeostasis, such as serum glucose, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), body mass index (BMI) z score, and CIMT. Overall, increased urine lead concentrations were positively correlated with the prevalence of MS, specifically the criteria of waist/BMI and serum HDL-C. The relationship between urine lead levels and CIMT remained unchanged in all subgroups. Conclusion In this study, we found that increased urinary levels of lead were positively associated with CVD risk factors, CIMT, and MS in this cohort. Future research to explore the pathogenic basis of exposure to lead and risk of CVDs and their risk factors are warranted.
- Published
- 2020