271 results on '"Korkmaz, Mehmet Hakan"'
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102. GERİATRİK OBSTRÜKTİF UYKU APNE HİPOPNE SENDROMLU HASTALARDA RİSK FAKTÖRLERİNİN DEGERLENDİRİLMESİ.
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ÜNLÜ, Ceren ERSÖZ, SAYLAM, Güleser, FIRAT, Hikmet, SELÇUK, Ömer Tarık, KORKMAZ, Mehmet Hakan, ARDIÇ, Sadık, and DAĞLI, Muharrem
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SLEEP apnea syndromes ,DISEASE relapse ,RESPIRATORY obstructions ,RETROSPECTIVE studies ,AGE groups ,DISEASE prevalence ,PATIENTS - Abstract
Copyright of Turkish Journal of Geriatrics / Türk Geriatri Dergisi is the property of Turkish Geriatrics Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2012
103. Coincidental Killian-Jamieson Diverticulum During Thyroid Surgery: A Rare Cause of Dysphagia.
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Saylam, Güleser, Keseroğlu, Kemal, Bayır, Ömer, Tatar, Emel Çadallı, and Korkmaz, Mehmet Hakan
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DIVERTICULUM ,THYROID gland surgery ,DEGLUTITION disorders ,TEMPORAL lobectomy ,SURGERY ,THERAPEUTICS - Abstract
Copyright of Turkish Archives of Otolaryngology / Türk Otolarengoloji Arsivi is the property of Turkish Otorhinolaryngology & Head & Neck Surgery Foundation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2016
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104. The Effect of N-Acetyl Cysteine on Biofilm Layer in an Experimental Chronic Otitis Media Model.
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Çallıoğlu, Elif Ersoy, Berçin, Ali Sami, Başdemir, Gülçin, Kiriş, Muzaffer, Tatar, İlkan, Oğuzhan, Tolga, Tüzüner, Arzu, Müderris, Tuba, Sargon, Mustafa, and Korkmaz, Mehmet Hakan
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ACETYLCYSTEINE ,OTITIS media ,SCANNING electron microscopes ,INNER ear ,MIDDLE ear - Abstract
Objective: The aim of this study was to investigate the efficacy of n-acetyl cysteine on the biofilm layer and on the course of the disease in resistant chronic otitis media. Methods: Thirty Wistar albino rats were used. Twenty-five rats were inoculated with 10x6 colonies with Pseudomonas aeruginosa strains through the tympanum. The inoculation was repeated one week later. Then the rats were observed without receiving any treatment. Meanwhile, two rats were lost due to malnutrition. The rats that were induced with chronic otitis media were separated into three groups. In Group 1 (n=18) the right ears of the rats were injected with 0.2% Ciprofloxacin + 0.1% Dexamethasone sodium phosphate + 0.5 mg/mL n-acetyl cysteine solution; in Group 2 (n=18) the left ears of the rats were locally injected with 0.2% Ciprofloxacin+0.1% Dexamethasone sodium phosphate solution. No treatment was applied to the inoculated ears of the rats in Group 3 (n=5, both ears). Group 4 (n= 5, both ears) was the control group with no inoculation or treatment. All rats in all groups were decapitated after a four-week follow-up, and histopathological and scanning electron microscope evaluations were performed. Results: In all rats induced with chronic otitis media, Pseudomonas aeruginosa was identified in the swab cultures taken three weeks after the second inoculation from their external auditory canal. Scanning electron microscope revealed biofilm formation in all chronic otitis media induced groups. No statistically significant differences were seen between Groups 1 and 2 in terms of suppuration levels, fibrosis, inner ear involvement, infection staging and biofilm formation (p>0.05). Suppuration, fibrosis and inner ear involvement were not observed in the control group. Conclusion: The efficacy of n-acetyl cysteine on the biofilm layer in chronic otitis media is controversial due to insufficient number of studies. While no effects of n-acetyl cysteine were found on the biofilm in the histopathological and scanning electron microscopy results of this study, further studies with n-acetyl cysteine at different concentrations are needed on different types of experimental animals to arrive at a conclusion. [ABSTRACT FROM AUTHOR]
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- 2019
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105. Programmed Death-1 Ligand-1 (PD-L1) Expression and Clinicopathologic Correlation in Salivary Gland Tumors.
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Özer, Tuğçe Pütürgeli, Saylam, Güleser, Han, Ünsal, Öcal, Bülent, Bayır, Ömer, and Korkmaz, Mehmet Hakan
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PROGRAMMED death-ligand 1 ,SALIVARY gland cancer ,SALIVARY glands ,SECONDARY primary cancer ,TUMOR classification ,HODGKIN'S disease - Abstract
Objective: Studies on markers such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) that transmit negative signals to cells have gained importance. Immunotherapies using checkpoint inhibitors like Anti-PD-1 and anti-PD-L1 (Programmed death-1 and ligand-1) have changed the management standards and prognoses of the diseases including malignant melanoma, lung cancer, renal cancer, Hodgkin's lymphoma. Accordingly, we planned a prospective study to investigate PD-L1 expression in patients who were operated on in our clinic for salivary gland tumors. Methods: Records of patients who were aged over 18 years and operated on and followed-up for a major or minor primary salivary gland tumor in our Ear Nose and Throat (ENT) and Head and Neck Surgery Clinic of the tertiary healthcare institution in the years from 2008 through 2018 were reviewed. Patients who had a second primary tumor, previously received chemotherapy or radiotherapy for another condition, were receiving immunosuppressive therapy or taking immunomodulatory medication were excluded. In total 80 patients, 70 with malignant pathology and 10 with benign pathology, were included in the study. The cases were grouped by diagnoses. The groups were evaluated in terms of age, gender, smoking, tumor localization, locoregional and distant metastasis (TNM) stage, type of surgery, histopathologic diagnosis, tumor staging, perineural invasion, lymphovascular invasion, need for adjuvant treatment, recurrence or metastasis development. PD-L1 expression was explored in both tumor cells and tumor-infiltrating mononuclear cells placed in formalin-fixed paraffin blocks. Results: Of the 70 malignant primary salivary gland tumors included in our study, 17 (24.3%) stained positive for PD-L1. PD-L1 positivity was observed in 12 (85.7%) of the 14 high grade tumors, two (18.1%) of the 11 intermediate grade tumors, and three (10.7%) ofthe 28 low grade tumors (p=0.004). PD-L1 stained positive in 10 (76.9%) of the 13 patients with lymphovascular invasion (p=0.02). No significant relationship was identified between PD-L1 staining and gender, age, smoking, tumor size, histopathologic diagnosis, perineural invasion of tumor, nodal metastasis, distant metastasis, staging, recurrence and survival (p>0.05). Also, no significant relationship was identified between the PD-L1 expression in tumor-infiltrating mononuclear cells and gender, age, smoking, tumor size, histopathologic diagnosis, perineural or lymphovascular invasion (LVI) of tumor, nodal metastasis, distant metastasis, staging and recurrence (p>0.05). PD-L1 expression in tumor-infiltrating mononuclear cells was observed to be increased as PD-L1 expression increased in tumor cells (p=0.000). Conclusion: In malignant salivary gland tumors, PD-L1 expression is associated with the staging of the tumor and the presence of LVI. Tumor-infiltrating mononuclear cell count was seen to be increased as PD-L1 expression increased. These results suggest that immunomodulation (PD-1/PD-L1 pathway inhibition) may be a treatment option for predicting the prognosis, reducing recurrence risk and increasing survival in selected patients with salivary gland cancer. [ABSTRACT FROM AUTHOR]
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- 2019
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106. Mukoselin eşlik ettiği Cedecea davisae nedeniyle gelişen atrofik rinit
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BAYIR, Ömer, AKSOY YILDIRIM, Gökçe, SAYLAM, Güleser, YÜKSEL, Elvan, ÖZDEK, Ali, and KORKMAZ, Mehmet Hakan
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Atrofik rinit,Cedecea davisae,endoskopik sinüs cerrahisi,mukosel ,Atrophic rhinitis,Cedecea davisae,endoscopic sinus surgery,mucocele - Abstract
Atrofik rinit, ilerleyici nazal mukozal atrofi ile karakterize kronik enflamatuvar bir hastalıktır. Nadir bir patojen olan Cedecea davisae, Enterobacteriaceae ailesinin yeni üyesidir. Bu yazıda, kültür testi Cedecea davisae gösteren bir atrofik rinit hastası sunuldu. Hasta eşlik eden posterior etmoid mukosel nedeniyle ameliyat edildi. İki ay levofloksasin ve nazal irigasyon uygulandı. Ameliyat sonrası altıncı ayda hastanın yakınma ve nazal bulgularında belirgin düzelme görüldü. Sonuç olarak, bu hastada Cedecea davisae’nin atrofik rinite ve mukosele neden olduğu düşünüldü. Hasta basit tedavi ile iyileşti. Bu bakteriler atrofik rinitin nedensel bir ajanı olarak dikkate alınmalıdır, Atrophic rhinitis is a chronic inflammatory disease characterized by progressive atrophy of nasal mucosa. Cedecea davisae, a rare pathogen, is a new member of Enterobacteriaceae family. In this article, we report a patient with atrophic rhinitis whose culture test revealed Cedecea davisae. The patient was operated due to accompanying posterior ethmoid mucocele. Levofloxacin and nasal irrigation were administered for two months. Significant improvement was observed in patient’s complaints and nasal signs at postoperative sixth month. In conclusion, Cedecea davisae has been thought to cause atrophic rhinitis and mucocele in this patient. Patient recovered with simple treatment. These bacteria should be kept in mind as a causative agent for atrophic rhinitis.
107. Aktinomikotik enfeksiyonla birlikte görülen tonsillolit: Olgu sunumu
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ÇADALLI TATAR, Emel, KARAÇAY, Mahmut, SAYLAM, Güleser, KORKMAZ, Mehmet Hakan, and ÖZDEK, Ali
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Actinomycotic infection,tonsillectomy,tonsillolith ,Aktinomikotik enfeksiyon,tonsillektomi,tonsillolit - Abstract
Rutin kulak burun boğaz muayenesinde rastlanan tonsiller kalsifikasyonlar nadir olmayan bir durumdur. Büyüklükleri, zorlukla görülebilecek kadar küçük parçacıklardan bezelye büyüklüğüne kadar değişe- bilmektedir ve bu bölgenin radyoopak lezyonlarının ayırıcı tanısında göz önünde bulundurulmalıdırlar. Bu yazıda sık tekrarlayan tonsil enfeksiyonu yakınmasıy- la başvuran ve tonsiller bölgede aktinomikotik enfek- siyonun eşlik ettiği büyük tonsilloliti olan 42 yaşında- ki erkek hasta sunuldu. Hastanın rutin kulak burun boğaz muayenesinde sağ palatin tonsile yerleşmiş büyük tonsillolit gözlemlendi. Hastaya genel anestezi altında tonsillektomi uygulandı. Histopatolojik sonuç tonsilloliti destekliyordu. Bununla birlikte ilginç şekil- de aktinomikotik enfeksiyon gözlendi. Tonsillolitin patogenezi tam olarak bilinmemektedir. Çoğu araş- tırmacılar tonsillolitlerin tekrarlayan tonsil enfeksi- yonlarına bağlı oluştuklarını öne sürmektedir. Kronik tonsiller bölge patolojilerinin ayırıcı tanısında tonsil- lolit de göz önünde bulundurulmalıdır, Tonsillar calcifications, tonsilloliths, are not rare conditions for routine ear nose throat examinations. Their size vary from barely visible to the pea size and they should be kept in mind in the differential diagnoses of radiopaque lesions in this region. We report a 42-year-old male patient who had a large tonsillolith together with an actinomycotic infection of tonsillar region. The patient complained about recurrent tonsillar infections. In his routine ear nose throat examination a large tonsillolith, lodged in the right palatine tonsil, was observed. The patient underwent tonsillectomy under general anesthesia. Histopathologic evaluation confirmed the diagnosis of tonsillolith. Interestingly, actinomycotic infection was observed. The pathogenesis of tonsilloliths is not completely defined. Many investigators have suggested that tonsilolliths originate as a result of recurrent tonsillar infections. Our purpose is to remind the tonsillolith in the differential diagnoses of chronic tonsillar region pathologies.
108. The outcome of intratympanic steroid therapy as a salvage treatment for sudden sensorineural hearing loss
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TAHİR, Emel, KESEROĞLU, Kemal, ER, Serap, ÖCAL, Bülent, ÖZDEK, Ali, AKIN, İstemihan, BAYIR, Ömer, and KORKMAZ, Mehmet Hakan
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Intratympanic injection,salvage treatment,sudden sensorineural hearing loss - Abstract
Objectives: The aim of this study is to evaluate the outcomes of intratympanic steroid ITS treatment for idiopathic sudden sensorineural hearing loss SSNHL . Patients and Methods: Between January 2014 and November 2016, medical charts of a total of 63 patients 47 males, 16 females; mean age: 44.2±17.5 years; range, 18 to 77 years who were hospitalized due to SSNHL were retrospectively analyzed. The patients were divided into two groups as those who received standard treatment Group 1, n=32 and those who received ITS treatment as a salvage treatment Group 2, n=31 . Treatment modalities and the results of pure tone audiometry tests were recorded. Recovery was assessed according to the Furuhashi criteria. Results: There was no significant difference in the hearing recovery rates between Group 1 and Group 2. In the patients receiving standard treatment, the recovery rate was significant 78% , while it was only 35.4% in the patients receiving ITS treatment p=0.361 . Conclusion: Although recent guidelines strongly recommend ITS treatment, in our study, ITS, which was started on Day 5 of admission, was not found to be superior to standard systemic treatment.
109. Addition of intratympanic steroid or hyperbaric oxygen treatment to systemic steroid treatment in sudden idiopathic sensorineural hearing loss treatment, and long-term results of salvage treatment
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KESEROĞLU, Kemal, TOPTAŞ, Gökhan, ULUAT, Ahmet, BAYIR, Ömer, TATAR, Emel Çadallı, SAYLAM, Güleser, KORKMAZ, Mehmet Hakan, and ÖZDEK, Ali
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Adult ,Male ,Salvage Therapy ,Hyperbaric Oxygenation ,Idiopathic sudden sensorineural hearing loss ,Hearing Loss, Sensorineural ,salvage treatment ,systemic steroid treatment ,Hearing Loss, Sudden ,Middle Aged ,hyperbaric oxygen therapy ,intratympanic steroid treatment ,Article ,Idiopathic sudden sensorineural hearing loss,systemic steroid treatment,hyperbaric oxygen therapy,intratympanic steroid treatment,salvage treatment ,Hearing ,Humans ,Female ,Glucocorticoids ,Aged ,Retrospective Studies - Abstract
Background/aim: This study aims to determine the therapeutic superiority of the addition of intratympanic steroid or hyperbaric oxygen therapy to systemic steroid treatment in idiopathic sudden sensorineural hearing loss as initial treatment, and evaluate the long-term results of salvage treatment. Materials and methods: This study was a retrospective clinical trial with a total of 96 patients with idiopathic sudden sensorineural hearing loss. Patients were divided into 3 groups. Group 1 n: 32 received systemic steroid treatment. Group 2 n: 32 received the Group 1 protocol plus intratympanic steroid treatment. Group 3 n: 32 received the Group 1 protocol plus hyperbaric oxygen treatment. Pretreatment and postinitial audiologic evaluations were performed, and the hearing outcome was analyzed with Furuhashi criteria. All patients, except those who experienced total recovery after initial treatment, were directed to salvage treatment. Audiologic assessment was performed again after salvage treatment and a mean follow-up period of 36.5 months. Results: Each group was homogenous according to demographics, audiologic data, and prognostic factors. There was no statistically significant difference in recovery and success rate within the 3 groups after initial treatment. P: 0.66, P: 0.248, respectively . Successful results were obtained after salvage treatment in only 3 patients 5% . These patients received follow-up treatment at a mean of 36.5 months, but there was no spontaneous recovery after the end of salvage treatment. Conclusion: The addition of intratympanic steroids or hyperbaric oxygen to systemic steroids caused no significant hearing improvement as the initial treatment of idiopathic sudden sensorineural hearing loss. The efficacy of salvage treatment was limited, and there was no spontaneous hearing improvement after the long-term follow-up.
110. Sistemik isotretinoin kullanımının ses üzerindeki etkisi
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ŞAHİN, Mustafa, ÇADALLI TATAR, Emel, CANPOLAT, Filiz, AKSOY YILDIRIM, Gökçe, and KORKMAZ, Mehmet Hakan
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Disfoni,isotretinoin,ses ,Dysphonia,isotretinoin,voice - Abstract
Amaç: Bu çalışmada kronik bir inflamatuvar hastalık olan akne vulgarisin tedavisinde sistemik Isotretionoin Iso kullanımının ses üzerindeki etkisi araştırıldı.Hastalar ve Yöntemler: Mart 2014 - Mayıs 2016 tarihleri arasında, akne vulgaris nedeniyle sistemik Iso kullanımı endikasyonu olan toplam 62 gönüllü hasta 40 kadın, 22 erkek; ort. yaş 22.4±5.5 yıl; dağılım 18-36 yıl çalışmaya dahil edildi. Tedavi öncesinde, tedavinin üçüncü ve altıncı aylarında ve tedavinin bitiminden altı ay sonra kulak burun boğaz muayenesi, videolaringostroboskopi VLS , akustik ses analizi ses basınç seviyesi [SPL], ortalama F0, ilk üç formant, jitter%, shimmer% ve ses harmoni oranı [NHR] yapıldı, maksimum fonasyon zamanı MPT ve s/z oranı ölçüldü. Algısal ses değerlendirilmesinde Ses Handikap İndeksi-10 VHI-10 ve GRBAS kullanıldı.Bulgular: Maksimum fonasyon zamanı, F0, ilk üç formant, SPL, GRBAS tedavi sırasında artış gösterdi , shimmer% değerlerinde ve VLS parametrelerinde istatistiksel olarak anlamlı bir değişiklik saptanmadı. Ses Handikap İndeksi-10, s/z oranı, jitter% ve NHR’nin tedavi sırasında anlamlı olarak arttığı görüldü.Sonuç: Standart klinik dozda altı aylık düzenli sistemik Iso tedavisinin ses kalitesi üzerinde hafif bir olumsuz etki gösterdiği ve bu etkinin tedavi sonlandırıldığında başlangıçtaki duruma döndüğü saptandı. Hastaların, özellikle de ses sanatçılarının, tedavi öncesinde bu olası yan etki açısından bilgilendirilmeleri önerilir, Objectives: This study aims to investigate the effects of oral systemic Isotretinoin Iso treatment of acne vulgaris, as a chronic inflammatory disease, on voice. Patients and Methods: Between March 2014 and May 2016, a total of 62 volunteer patients 40 females, 22 males; mean age 22.4±5.5 years; range 18 to 36 years with systemic Iso therapy indication due to acne vulgaris were included in the study. Ear nose and throat examination, videolaryngostroboscopy VLS and acoustic voice analysis sound pressure level [SPL], mean F0, first three formants, jitter%, shimmer% and noise to harmonic ratio [NHR] were performed, maximum phonation time MPT and s/z ratio were measured at pretreatment, third and sixth months of treatment and sixth month after the treatment was stopped. The Voice Handicap Index VHI-10 and the GRBAS scales were performed for perceptual voice evaluation. Results: There was no statistically significant difference in MPT, F0, the first three formants, SPL, GRBAS increased during the treatment , shimmer% ratings and VLS parameters during the Iso treatment. Voice Handicap Index-10, s/z ratio, jitter% and NHR were observed to have increased significantly during the treatment. Conclusion: Six-month regular systemic Iso treatment at standard clinical doses has mild negative effects on voice quality and this impact returns to baseline after the treatment is stopped. It is recommended that patients, especially vocal artists, to be informed prior to treatment about this possible side effect.
111. Dilde submukozal yerleşimli schwannom
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ULUSOY, Bülent, BOZDEMİR, Kazım, ERSOY ÇALLIOĞLU, Elif, KUTLUHAN, Ahmet, and KORKMAZ, Mehmet Hakan
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Nörilemmoma,oral kavite,schwannom,dil ,Neurilemmoma,oral cavity,schwannoma,tongue - Abstract
Schwannom veya nörilemmoma periferik sinirlerin Schwann hücrelerinden kaynaklanan; yavaş büyüyen, soliter ve kapsüllü bir benign tümördür. Dil schwannomları nadirdir. Kırk altı yaşında bir erkek hasta yaklaşık bir yıldır devam eden, dilin sağ yarısında şişlik yakınması ile başvurdu. Dilin sağ kenarında submukozal yerleşimli yaklaşık 1x1 cm’lik kitle tespit edildi. Submukozal kitle lokal anestezi altında total olarak çıkarıldı. Patolojik inceleme schwannom ile uyumlu idi. Dil schwannomları dil kitlelerinin ayırıcı tanısında dikkate alınmalıdır, Schwannoma or neurilemmoma is a slow growing, solitary, and encapsulated benign tumor originating from Schwann cells of the peripheral nerves. Lingual schwannomas are rare. A 46-year-old male patient admitted with a complaint of swelling on the right half of the tongue for one year. An approximately 1x1 cm submucosal mass was detected on the right side of the tongue. The submucosal mass was totally excised under local anesthesia. Pathological examination was consistent with schwannoma. Lingual schwannomas should be considered in the differential diagnosis of tongue masses.
112. Gebelikte diferansiye tiroid kanseri cerrahisi ve anestezi ilkeleri: Üç olgu sunumu
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BAYIR, Ömer, POLAT, Reyhan, SAYLAM, Güleser, ÖCAL, Bülent, ÇAKAL, Erman, DELİBAŞI, Tuncay, and KORKMAZ, Mehmet Hakan
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Differentiated thyroid cancer,pregnancy,thyroid surgery ,Diferansiye tiroid kanseri,gebelik,tiroid cerrahisi - Abstract
Gebelikte tiroid nodülü gelişmesi nadirdir ancak bu nodülün kanser olma oranı yüksektir. Bu yazıda, diferansiye tiroid karsinomu tanısıyla ameliyat edilen üç gebe kadının tıbbi sonuçları literatür eşliğinde sunuldu. Üç olgunun ultrason bulguları malign özellikler içermesi nedeniyle, ince iğne aspirasyon biyopsisi İİAB yapıldı. Sitolojik inceleme sonucu papiller tiroid karsinom PTK olarak bildirildi. Tüm olgularda cerrahi ikinci trimesterde gerçekleştirildi. Bir olgumuza total tiroidektomi ile birlikte seviye III ve seviye VI boyun diseksiyonu ve iki olguya total tiroidektomi ile seviye VI boyun diseksiyonu uygulandı. Patolojik inceleme sonucu da, PTK olarak bildirildi. Diseksiyon materyallerinde lenf nodu metastazı saptandı. Ameliyat sırası ve ameliyat sonrası erken dönemde komplikasyon gelişmedi ve ameliyat sonrası bir yıllık takip sırasında nüks veya rezidü bulgusuna rastlanmadı. Sonuç olarak, ilk trimesterde doğuştan malformasyonların riski yüksek olduğu için, yapılacak ameliyat elektif ise, ikinci trimesterde gerçekleştirilmelidir. Sonografide malign özellikler içeren ve PTK’nin İİAB ile doğrulandığı gebelere ameliyat öncesi, sırası ve sonrasında gerekli önlemler alınarak güvenle cerrahi uygulanabilir. Bu hastaların anestezisinde premedikasyon yapılmamalı, hastalara uygun pozisyon verilmeli ve teratojenik ajanlar kullanılmamalıdır. Ameliyat sonrasında anne ve fetüs yakından takip edilmelidir, Development of thyroid nodule during pregnancy is rare, however the cancer rate of this nodule is high. Herein, we present medical outcomes of three pregnant women who were operated with the diagnosis of differentiated thyroid carcinoma in the light of literature. As sonographic findings of three cases showed malignant characteristics, fine needle aspiration biopsy FNAB was performed. Cytological examination result was reported as papillary thyroid carcinoma PTC . Surgery was performed in the second trimester in all cases. One case underwent total thyroidectomy with neck dissection at level III and VI and two cases underwent total thyroidectomy with neck dissection at level VI. Pathological examination result was also reported as PTC. Lymph node metastases in the dissected materials were detected. During the intraoperative and early postoperative period, no complications occurred and no findings of recurrence or residues were observed during one-year follow-up following surgery. In conclusion, as the first trimester has an increased risk of congenital malformations, elective surgery should be performed at the second trimester, if applicable. In pregnants with malignant sonographic features and PTC confirmed by FNAB, surgery can be applied safely by taking precautions during pre-/peri- and postoperative period. These patients should not be given premedication for anesthesia, should be properly positioned and teratogenic agents should be avoided. After surgery, mother and fetus should be monitored closely.
113. Kimura hastalığında atipik tablo
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BAYIR, Ömer, KARAGÖZ, Tuğba, ÇADALLI TATAR, Emel, ÖZDEK, Ali, HAN, Ünsal, SAYLAM, Güleser, and KORKMAZ, Mehmet Hakan
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Eozinofilik anjiyolenfoid hiperplazi,kronik hastalık,Kimura hastalığı ,Angiolymphoid hyperplasia with eosinophilia,chronic disease,Kimura’s disease - Abstract
Kimura hastalığı özellikle baş boyun bölgesinde subkütanöz doku ve tükürük bezi tutulumuyla seyreden, etyolojisi tam olarak aydınlatılamamış nadir görülen kronik enflamatuvar bir hastalıktır. Hastalık baş boyun bölgesinde en çok preauriküler bölge, submandibüler bölge, servikal lenf nodları ve majör tükürük bezi tutulumu ile görülmekle beraber, glomerulonefrit gelişimine bağlı olarak nefrotik sendrom da hastalığın ek sistemik patolojisi olarak karşımıza çıkmaktadır. Karakteristik histolojik özellikleri olan foliküler hiperplazi, eozinofil infiltrasyonu ve postkapiller venlerde çoğalması ile ayırıcı tanısı yapılmaktadır. Kimura hastalığı eozinofilik anjiyolenfoid hiperplazi ile zaman zaman karıştırılmaktaysa da her iki hastalık ayrı klinik ve histolojik özelliklere sahiptir. Bu olgu sunumunda, iki yıldır sağ bukkal bölgede yavaş progresyon gösteren kitle ile kliniğimize başvuran, fizik muayenesinde sağ bukkal bölgede yaklaşık 3x3 cm boyutlarında yumuşak kıvamlı kitle palpe edilen, intraoral total kitle eksizyonu uygulanan, histopatolojik incelemesi ‘Kimura hastalığı ile uyumlu’ olarak bildirilen 57 yaşında erkek hastanın kliniği, patolojisi ve tedavisi literatür eşliğinde tartışıldı, Kimura’s disease is a rare chronic inflammatory disorder with an unknown etiology which presents with the involvements of salivary glands and subdermal tissue in the head or neck region, in particular. Besides the most common manifestations of the disease; as the involvements of preauricular region, submandibular region, cervical lymph nodes and major salivary glands, nephrotic syndrome, as an additional systemic pathology, may be also seen due to glomerulonephritis. The differential diagnosis is made with the identification of characteristic histological features as follicular hyperplasia, eosinophil infiltration, and proliferation of the postcapillary venules. Although Kimura’s disease may occasionally resemble angiolymphoid hyperplasia with eosinophilia, both have different clinical and histological features. In this case report, we discuss the clinical, histopathological features and treatment of a 57-year-old male patient admitted with a slowly progressing mass in his right buccal region for almost two years, which was approximately 3x3 cm in diameter and soft to palpation, and was excised completely by an intraoral approach and reported histopatologically as Kimura’s disease in the light of literature.
114. Nazal dorsal müköz kist oluşumu: Rinoplastinin nadir ve önlenebilir komplikasyonu
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ERSÖZ ÜNLÜ, Ceren, SAYLAM, Güleser, KORKMAZ, Mehmet Hakan, ÇADALLI TATAR, Emel, and ÖZDEK, Ali
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Komplikasyon,müköz kist,rinoplasti,cerrahi yaklaşım ,Complication,mucous cyst,rhinoplasty,surgical approach - Abstract
Rinoplasti sonrasında nazal dorsal müköz kist oluşumu kulak burun boğaz alanında nadir görülen ve önlenebilir bir komplikasyondur. Bu komplikas- yonun önlenmesi için kemik, kıkırdak ve mukoza kalıntıları titizlikle çıkarılmalıdır. Kıkırdak insizyo- nu ve osteotomi sırasında mukozal bütünlüğün korunması ve bütün osteotomilerin tamamlanması müköz kist oluşumunun önlenmesinde önem taşı- maktadır. Bu komplikasyonun tedavisi, kistin kap- sülüyle birlikte tamamen çıkarılmasıdır. Bu yazıda, rinoplasti sonrası altı ay içinde gelişen nazal dorsal kist olgusu, kısa bir literatür derlemesi ile sunuldu, Nasal dorsal mucous cyst formation after rhinoplasty is a rare and preventable complication in otorhinolaryngological area. To prevent this complication bony, cartilage, and mucous remnants should be removed meticulously. Maintaining mucosal integrity during cartilage incisions and osteotomy and completing all osteotomies are very important in preventing mucous cyst formation. The treatment of this complication is the complete excision of the cyst with its capsule. In this article, we report a case of nasal dorsal cyst that developed within six months after rhinoplasty with a brief review of the literature.
115. Thiol-disulphide homeostasis in chronic sinusitis without polyposis
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BOZDEMİR, Kazım, SEZGİN, Arife, AKKOZ, Ahmet, EREL, Özcan, and KORKMAZ, Mehmet Hakan
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Chronic sinusitis,homesostasis,thiol-disulphide - Abstract
Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis. Patients and Methods: A total of 60 subjects 30 chronic sinusitis patients and 30 healthy volunteers were included in the study. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu. Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group. The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients had significantly lower native and thiol value than control group p
116. Orbital apseyle seyreden rino-orbital mukormikozis: Olgu sunumu
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ÇADALLI TATAR, Emel, AKPINAR SÜRENOĞLU, Ünzile, IŞIK, Eray, TÜTÜNCÜ, Ediz, and KORKMAZ, Mehmet Hakan
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Early diagnosis,orbital abscess,rhinoorbital mucormycosisi ,Erken tanı,orbital apse,rinoorbital mukormikozis - Abstract
Sinonazal mukormikozis nadir görülen, hayatı tehdit edici ve sinsi bir mantar enfeksiyonudur. Kontrolsüz diyabet ve immünsüpresyon en önemli risk faktörleridir. Klinik olarak burun boşluğunda siyah nekrotik dokular ve krutlanma ile karakterizedir. Akut fulminan rinosinü- zitlerde ve özellikle de mukor türlerinden kaynaklanan enfeksiyonlarda, burun mukozasında izlenen siyah skar dokuları patognomoniktir. Yüksek derecede şüphe uyandıran risk grubunda tanı histopatolojik incelemey- le doğrulanır. Rinoorbital formu daha da nadirdir ve bulgular göz ağrısından oftalmopleji ve körlüğe kadar değişiklik gösterir. Bu yazıda, kliniğimize sol gözde ekzoftalmus, çift görme ve baş ağrısı yakınmaları ile başvuran ve kontrolsüz tip 2 diyabeti bulunan 72 yaşın- da bir kadın hasta sunuldu. Muayenesinde sol orta meatusta pürülan akıntı izlenen hastanın bilgisayarlı tomografisinde sol orbital apse tespit edildi. Acil endos- kopik sinüs cerrahisi uygulandı. Hastada herhangi bir nekrotik doku gözlenmemekle birlikte, granülasyon dokuları görüldü ve orbital kaviteden püy drene oldu. Histopatolojik inceleme sonucu invaziv mukormikozis olarak bildirildi. Bu olgu rinoorbital mukormikozisde erken tanı ve tedavinin önemini vurgulamak amacıyla sunuldu, Sinonasal mucormycosis is a rare, life-threatening and insidious fungal infection. Uncontrolled diabetes mellitus and immunsupression are the most important risk factors. The infection is clinically characterized by black necrotic tissues and crusting in the nasal cavity. In acute fulminant rhinosinusitis and particularly in infections caused by mucor species, black scar tissues seen on the nasal mucosa are pathognomonic. High level of suspicion in the risk group the diagnosis is confirmed by histopathological examination. The rhinoorbital form is even rarer and the findings may range from orbital pain to ophtalmoplegia and blindness. In this report we present a 72-year-old female patient with uncontrolled type 2 diabetes mellitus who was admited with the complaints of exophtalmos in the left eye, diplopia and headache. In the physical examination there was purulent discharge in the middle meatus and left orbital abscess was detected on computed tomography. We performed an emergency endoscopic sinus surgery. While we did not observe any necrotic tissues, granulation tissues were detected and pus was drained from the orbital cavity. The result of the histopathological examination was reported as invasive mucormycosis. We presented this case to emphasize the importance of early diagnosis and treatment of rhinoorbital mucormycosis.
117. İki taraflı burun içi ilerletme/rotasyon flepleri kullanarak nazal septal perforasyon kapama
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ÖZDEK, Ali, BAYIR, Ömer, DÜNDAR, Yusuf, ÇADALLI TATAR, Emel, SAYLAM, Güleser, and KORKMAZ, Mehmet Hakan
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Nazal septum,nazal septum perforasyonu,rekonstrüktif cerrahi işlem,cerrahi flep ,Nasal septum,nasal septum perforation,reconstructive surgical procedure,surgical flap - Abstract
Amaç: Bu çalışmada açık teknik septoplasti yoluyla iki taraflı burun içi ilerletme/rotasyon flepleri kullanılarak uygulanan nazal septal perforasyon NSP onarımındaki deneyimimiz sunuldu.Hastalar ve Yöntemler: Ocak 2009 - Şubat 2013 tarihleri arasında kliniğimizde NSP nedeniyle ameliyat edilen 28 ardışık hastanın tıbbi kayıtları retrospektif olarak incelendi. Hastaların demografik özellikleri ve cerrahi bulguları değerlendirildi.Bulgular: Nazal septal perforasyonun en sık nedeni 18 hastada %64 daha önce geçirilmiş nazal septum cerrahisi idi. En sık görülen semptom 21 hastada %75 burun içerisinde kabuklanma idi. Perforasyon çapı 10-30 mm arasında değişmekteydi. Nazal septal perforasyon tamiri ile birlikte aynı zamanda beş hastada septoplasti, üç hastada septorinoplasti uygulandı. Nazoseptal iskeleti desteklemek amacı ile gerekli olduğu durumlarda nazal septal kartilaj ve aurikula konkal kartilaj kullanıldı. Ameliyat sırası ya da sonrası majör komplikasyon ile karşılaşılmadı. Ameliyat sonrası ortalama takip süresi 23 ay idi. Takip sürecinde beş hastada %18 kolumellar retraksiyon görüldü. Nazal septal perforasyon 24 hastada %86 başarı ile kapatıldı. Pinpoint perforasyon iki hastada görülürken, iki hastada perforasyon 5 mm’nin altında idi. Sonuç: İki taraflı burun içi ilerletme/rotasyon flepleri kullanılarak uygulanan NSP kapama kıyaslanabilir düzeyde yüksek başarı oranına sahiptir. Bu nedenle, bu teknik özellikle küçük ve orta çaplı perforasyonlara kolaylıkla uygulanabilir, Objectives: This study aims to report our experience on surgical repair of nasal septal perforations NSP using bilateral intranasal advancement/rotation flaps with open septoplasty technique. Patients and Methods: Medical records of 28 consecutive patients who were operated for NSP in our clinic between January 2009 and February 2013 were retrospectively analyzed. Demographic features of the patients and surgical results were evaluated. Results: The most common cause of NSP was previous septal surgery in 18 64% of the patients. Nasal crusting was the most common symptom in 21 patients 75% . Perforation size ranged from 10 to 30 mm in diameter. Septoplasty was performed in five patients, while septorhinoplasty was performed in three patients simultaneously to the NSP repair. Nasal septal cartilage and auricular chonchal cartilage were used to support the nasoseptal skeleton, if required. There were no major intra- or postoperative complications. The mean postoperative follow-up period was 23 months. During follow-up, there was mild columellar retraction in five patients 18% . Nasal septal perforation was closed successfully in 24 patients 86% . Pinpoint perforation remained in two patients and perforation size was smaller than 5 mm in two patients. Conclusion: Closing the NSP with bilateral intranasal advancement/rotation flaps has a comparable high success rate. Therefore, this technique can be easily applied to small-medium sized septal perforations.
118. Etmoidektomili veya etmoidektomisiz endoskopik transnazal sfenoidotomi
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ERYILMAZ, Adil, DURSUN, Engin, SAYLAM, Güleser, GÖÇER, Celil, DAĞLI, Muharrem, and KORKMAZ, Mehmet Hakan
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Etmoid kemik/cerrahi,sfenoid sinüzit/cerrahi,endoskopi/yöntem ,Ethmoid bone/surgery,sphenoid sinusitis/ surgery,endoscopy/methods - Abstract
Amaç: Enflamatuvar sfenoid sinüs hastalığında ESSH etmoidektomili veya etmoidektomisiz endoskopik transnazal sfenoidotomi ETNS uygulamasıdeğerlendirildi.Hastalar ve Yöntemler: Çalışmada ESSH nedeniyleetmoidektomili n=37 veya etmoidektomisiz n=5 ETNS uygulanan 42 hasta geriye dönük olarak değerlendirildi. Hastalar bilgisayarlı tomografi bulgularına dayanan evreleme sistemimizle sınıflandırıldı.Bulgular: En yaygın semptom postnazal akıntı idi n=37, %88.1 . Kronik sinüzite 25 hastada sinonazalpolip eşlik etmekteydi %59.5 . Beş hastada %11.9 izole hastalık vardı. On altı hastada %38.1 tutulum tektaraflıydı. Beş olguda %11.9 evre 1, 15 olguda %35.7 evre 2, 22 olguda %52.4 evre 3 hastalık görüldü. Cerrahi 68 tarafa uygulandı. Bunların 63’ündecerrahiye etmoidektomi eklendi. Etmoidektomi uygulanan hastaların sekizinde destekleyici girişime ihtiyaç duyuldu. Sekiz hastada %19 en az bir komplikasyonla karşılaşıldı. Bu komplikasyonlar şunlardı:ciddi perioperatif kanama n=2 , ameliyat sonrası erken dönem kanama n=2 , lamina papiraseada hafifyaralanma n=4 ve sineşi n=5 .Sonuç: İzole ESSH olan hastalarda etmoidektomisizETNS ile direkt yaklaşım tercih edilecek cerrahi tekniktir; diğer paranazal sinüslerde de hastalığı olanlarda ise ETNS’nin etmoidektomi ile birlikte uygulanması gerekir, Objectives: We evaluated endoscopic transnasal sphenoidotomy ETNS with or vvithout ethmoidecto my in patients with inflammatory sphenoid sinüs dis- ease ISSD .Patients and Methods: A retrospective revievv was conducted in 42 patients 17 males, 25 females; mean age 41 years; range 17 to 67 years who undervvent ETNS with n=37 or vvithout n=5 ethmoidectomy tor ISSD. The disase was staged according to our staging System based on computed tomography findings.Results: Postnasal drainage was the most common symptom n=37, 88.1% . Chronic rhinosinusitis was accompanied by sinonasal polyps in 25 patients 59.5% . Five patients 11.9% had isolated sphenoid disease and 16 patients 38.1% had unilateral disease.Five patients 11.9% had stage 1,15 patients 35.7% had stage 2, and 22 patients 52.4% had stage 3 dis ease. Surgery involved 68 sides. Ethmoidectomy was used in 63 sides of 37 patients, eight of whom required a supplementary procedure. At least one complication was seen in eight patients 19% , including severe peri- operative hemorrhage n=2 , early postoperative hem- orrhage n=2 , minör injuries to the lamina papyracea n=4 , and synechiae n=5 .Conclusion: İn patients with isolated ISSD, the direct approach to the sphenoid sinüs by ETNS vvithout eth moidectomy is a favorable technique, vvhereas ETNS with ethmoidectomy is necessary for patients with concurrent disease in other paranasal sinuses.
119. Prognostic role of homeostasis model assessment and oral glucose tolerance test in nondiabetic patients with Bell's palsy
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KARAGÖZ, Tuğba, BAYIR, Ömer, TATAR, Emel Çadallı, ÇAKAL, Erman, ÖZDEK, Ali, KESEROĞLU, Kemal, ŞAHİN, Mustafa, and KORKMAZ, Mehmet Hakan
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Bell's palsy,insulin resistance,prediabetes,HOMA-IR index - Abstract
Background/aim: We aimed to reveal the incidence and predictive role of insulin resistance and distorted oral glucose tolerance test in nondiabetic patients with Bell's Palsy BP . Materials and methods: Eighty-six patients with BP and 28 control subjects; all with normal blood glucose levels and no history of diabetes, were enrolled in the study. We investigated insulin resistance IR in all subjects, in terms of HOMA-IR greater than 2.7. Sixtytwo of the patients also underwent an oral glucose tolerance test OGTT . Results: The mean HOMA-IR value was significantly increased in patients, compared to the control group 3.2 vs 1.6; P < 0.01 . IR was detected more in BP patients than in controls P < 0.05 . The patients with higher HOMA-IR values had more severe facial dysfunction at the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value 75 days vs 42 days; P < 0.05 . Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery time was significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia 68 days, 52 days, and 32 days, respectively; P < 0.01 . Conclusion: There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role of predicting BP prognosis at presentation.
120. Tıkayıcı uyku apnesine neden olan dev retrofarengeal lipom
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KAYA ÇELİK, Elif, BAYIR, Ömer, KESEROĞLU, Kemal, SAYLAM, Güleser, SAKA, Cem, and KORKMAZ, Mehmet Hakan
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Lipoma,obstructive sleep apnea,retropharyngeal space,surgery ,Lipom,tıkayıcı uyku apnesi,retrofarengeal alan,cerrahi - Abstract
Retrofarengeal bölgenin tümörleri sık görülmemekle birlikte, bu bölgede lipomlara oldukça nadir rastlanır. Retrofarengeal bölgede tümörü olan hastalar, bu bölgenin genişleme özelliği nedeniyle, uzun süre asemptomatik olabilir. Bu yazıda, dev retrofarengeal lipom nedeniyle şiddetli düzeyde tıkayıcı uyku apnesi olan bir olgu sunuldu, The tumors of retropharyngeal area are infrequent and lipomas of this region are extremely rarely seen. Patients with tumors of the retropharyngeal area may remain asymptomatic for a long time, due to the expansion ability of this space. Herein, we report a case with severe obstructive sleep apnea due to a huge retropharyngeal lipoma.
121. Identification of Mitochondrial DNA Gene Mutations in a Turkish Head and Neck Squamous Cancer Patient Group.
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MUTLU, Pelin, MUTLU, Murad, YALCIN AZARKAN, Serap, KESEROGLU, Kemal, BAYIR, Omer, SAYLAM, Guleser, and KORKMAZ, Mehmet Hakan
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HEAD & neck cancer , *MITOCHONDRIAL DNA , *GENETIC mutation , *CANCER patients , *ETHNIC groups , *SQUAMOUS cell carcinoma - Abstract
Besides the variations in genomic DNA, mitochondrial DNA (mtDNA) mutations are also responsible for many diseases, including cancer. MtDNA among individuals from the same and different ethnic groups is highly polymorphic. In the present study, we screened mitochondrial CO-1 and ND4 gene sequences of Turkish head and neck squamous cell carcinoma (HNSCC) patient group and examined the possible relationship between CO-1 and ND4 gene mutations and the development of the disease. Sixty unrelated Turkish HNSCC patients and thirty six unrelated healthy volunteers from different geographic regions of Turkey were included in this study. Total DNA isolation from blood samples were carried out and amplification of CO-1 and ND4 gene regions of mtDNA were performed by PCR reaction. PCR products were purified and sequencing was carried out by Sanger sequencing. Two mutations in CO-1 gene were identified and among them A6272d mutation was found as statistically significant in the studied HNSCC patient group with respect to control group (p< 0.05). Also differences in the alpha helix structure of the protein in patients with mutations were observed. Two mutations (A11251G and T11017TA) in the ND4 gene region were identified, however, none of these mutations were seem to be responsible for the disease development (p>0.05). As a conclusion, for the studied Turkish patient group we showed that A6272d mutation in CO-1 gene can be related to HNSCC development (p< 0.05). However, we cannot detect a statistically significant alteration between patient and control groups for ND4 gene (p>0.05). These differences can be due to ethnic differences. [ABSTRACT FROM AUTHOR]
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- 2022
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- View/download PDF
122. Normal bireylerde ve migren tanısı almış bireylerde vestibüler efferent sistemin cvemp cevapları üzerindeki etkisinin değerlendirilmesi
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Turan Dizdar, Handan, Korkmaz, Mehmet Hakan, and Diğer
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Otorhinolaryngology (Ear-Nose-Throat) ,Kulak Burun ve Boğaz - Abstract
Normal Bireylerde ve Migren Tanısı Almış Bireylerde Vestibüler Efferent Sistemin cVEMP Cevapları Üzerindeki Etkisinin DeğerlendirilmesiBu çalışmanın amacı, sağlıklı bireylerde ve auralı/aurasız migren tanısı almış bireylerde görsel uyaranların cVEMP cevaplarına etkisinin araştırılmasıdır. Sağlıklı bireyler, auralı migren ve aurasız migren tanısı almış bireylerden oluşan toplam 68 kişi çalışmaya dahil edilmiştir. Tüm bireylere pursuit ve optokinetik uyaranlar verilerek cVEMP testi yapılmıştır. Sağlıklı bireylerde, görsel uyaran olmadan yapılan cVEMP testi ile karşılaştırıldığında sola doğru optokinetik uyaran verilerek yapılan cVEMP testinde hem solda hem de sağ tarafta P1N1 latansında, sağda N1 amplitüdünde, sağa doğru optokinetik uyaran verildiğinde ise solda P1N1 latansında, pursuit uyaran verildiğinde ise hem N1 hem de P1N1 latansında sağda ve sol tarafta anlamlı farklılık elde edildi (p
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- 2019
123. Kronik otitis media'da video head impulse test (vHIT) bulgularının değerlendirilmesi
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Demir, Gülcan, Korkmaz, Mehmet Hakan, and Kulak Burun Boğaz Anabilim Dalı
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Ear diseases ,Video head impulse test ,Scales ,Otorhinolaryngology (Ear-Nose-Throat) ,Kulak Burun ve Boğaz ,Dizziness ,Otitis media ,Vestibular function tests - Abstract
Bu çalışmanın amacı kronik otitis media'lı (KOM) hastaların vestibüler sistemlerinde hasar olup olmadığının vHIT ile değerlendirilmesi ve sağlıklı bireylerle karşılaştırılmasıdır. Yaşları 18-65 arasında 60 tek taraflı KOM hastası ve 30 sağlıklı birey çalışmaya dahil edilmiştir. Çalışmaya dahil edilen hastaların hepsinde kulak zarı perforasyonu varken 30 aktif akıntılı ve 30 akıntısız KOM hastası olarak alt gruplara ayrılarak incelenmiştir. Tüm bireylere kulak burun boğaz muayenesi, odyolojik değerlendirme, baş dönmesi algısının ölçüldüğü Baş Dönmesi Engellilik Envanteri (BEE) ve vHIT yapılmıştır. Çalışmada elde edilen vHIT sonuçlarında refiksasyon sakkadları sadece 3 kişide görüldüğü için sakkad parametresi analize dahil edilmemiştir. Çalışma ve kontrol grubu arasında lateral kanallarda anlamlı fark saptanmazken posterior ve anterior kanallarda anlamlı fark saptanmıştır. Hasta grubunda hasta kulak ve karşı kulak karşılaştırılmalarında ise yine lateral kanallarda anlamlı fark saptanmamış olup posterior ve anterior kanallarda ise çeşitli yönlerde anlamlı farklılık saptanmıştır. Hastalar aktif akıntılı ve inaktif akıntısız alt gruplara ayrıldığında ise herhangi bir anlamlılık saptanmamıştır. Bireylerin baş dönmesi algısını ölçmek için uygulanan BEE sonuçlarında hasta grubu ve kontrol grubu arasında anlamlı fark saptanmamış olup aktif akıntısı olan bireylerin baş dönmesi algısının anlamlı olarak daha yüksek olduğu saptanmıştır. Sonuç olarak KOM'un anterior ve posterior kanalları etkileyebileceğinin yanında aktif akıntısı olan KOM'lu hastaların baş dönmesi algısının yüksek olduğu saptanmıştır. Ancak anterior ve posterior kanallarda gözlenen tüm bu istatistiksel anlamlı farklılıklar klinik olarak patolojik değildir. Bunun yanında çalışmada anterior ve posterior kanallarda çeşitli istatistiksel anlamlı farlılıkların gözlenmesinden dolayı vHIT testinin KOM hastalarının vestibüler hasarının değerlendirmesinde kullanılabileceği düşünülmektedir. Ayrıca literatür de KOM hastalarında vHIT uygulanan çalışma olmaması yönünden daha ileride yapılacak çalışmalara zemin hazırlayabileceği düşünülmektedir. The aim of this study is; the evaluation of vestibular system with vHIT in patients with chronic otitis media (COM). Sixty unilateral COM patients between the ages of 18-65 and 30 healthy individuals were included in the study. The patients werw subdivided into 2 groups; 30 patients in the first group had COM with active infection and drainge, 30 patients in the second group had no drainge inactive flow-free COM patients. All subjects underwent ear nose examination, audiological evaluation, dizziness handicap inventory (DHI) and vHIT which measured the perception of dizziness. The saccade parameters in vHIT were not included in the analysis since the saccades were seen in only 3 subjects. There was no significant difference between the study and control groups for the lateral semicircullar channels (SCC) but there was a significant difference between the posterior and anterior SCC. In the patient group, there was no significant difference in the lateral SCC between the diseased ear and the opposite normal ear and there were significant differences in the posterior and anterior SCC in various directions. When the patients were subdivided into active ear drainge inactive subgroups, no significant difference was found. No significant difference was found between the patient and control group in the DHI results; which was applied to measure the perception of dizziness. İt was found that the perception of dizziness in the individuals with active discharge was significantly higher. As a result, COM was found to affect the anterior and posterior SCC, but it was found that dizziness of the patients with active dischange was higher. However, all these significant statistical differences observed in the anterior and posterior canals are not clinically pathological. In addition, vHIT test may be used to evaluate the vestibular damage of KOM patients due to the significant differences in the anterior and posterior channels. In addition, it is also considered that our study will be aid to further future studies. 81
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- 2019
124. Multipl sklerozlu hastalarda vestibuler evoked myogenik potansiyel, video head impulse test ve görüntüleme bulgularının değerlendirilmesi
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Barmak, Elife, Korkmaz, Mehmet Hakan, and Kulak Burun Boğaz Anabilim Dalı
- Subjects
Multiple sclerosis ,Vestibule ,Magnetic resonance imaging ,Otorhinolaryngology (Ear-Nose-Throat) ,Evoked potentials ,Kulak Burun ve Boğaz ,Vestibular function tests - Abstract
Çalışmamızda, ataklarla seyreden (Relapsing-Remitting) tipteki MS tanısı konulmuş vakalarda vestibüler sinir, utrikül, sakkül ve yarım daire kanallarından oluşan periferik vestibüler end organ hasarının olup olmadığı VEMP/vHIT testi kullanılarak araştırılmıştır. Ataklarla seyreden tipteki MS hastalarının VEMP/vHIT bulguları sağlıklı bireylerle karşılaştırılmış, VEMP/vHIT parametreleri ve beyin magnetik rezonans görüntüleme (MRG) bulguları araştırılmıştır. Bu amaçla çalışmaya, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Nöroloji Anabilim Dalı'nda Nöroloji hekimi tarafından ataklarla seyreden tipte MS tanısı konulan 18-60 yaşları arasında toplam 50 birey ile aynı yaş grubunda normal işitmesi olan ve denge problemi olmayan 35 normal ve sağlıklı birey dâhil edilmiştir. Grupların değerlendirmesinde kullanılan sVEMP, oVEMP ve vHIT testleri Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz Anabilim Dalı Odyoloji Ünite'sinde yapılmıştır. MS grubunun EDSS ve MRG bulguları nöroloji hekimleri tarafından değerlendirilmiştir.Çalışmada elde edilen verilerin analizi sonucunda, MS grubunda oVEMP'te cevap elde edilme oranları kontrol grubuna göre anlamlı olarak farklı elde edilirken, sVEMP cevapları açısından anlamlı farklılık saptanmamıştır. İki grup arasında sVEMP/oVEMP ortalama latansları ve vHIT kazançları açısından anlamlı farklılık bulunmamıştır. Fakat sVEMP amplitüdleri açısından iki grup karşılaştırıldığında MS grubunda anlamlı derecede düşük elde edilmiştir. MS'li grupta beyin sapı serebellar semptomları, beyin sapı göz hareket bozukluğu semptomları, internükleer oftalmopleji, geçirilmiş optik nevrit atağı, hastalık süresi, EDSS puanı, toplam atak sayısı ile VEMP/ vHIT arasında anlamlı bir ilişki gözlenmemiştir. MS'li grupta anormal oVEMP görülme oranı kontrol grubuna göre anlamlı derecede yüksek bulunurken, anormal sVEMP ve vHIT görülme oranı açısından gruplar arasında anlamlı bulunmamıştır. MS grubunda MRG'de lezyon yerleşim yerine göre mezensefalon, bulbus, pons ve servikal lezyon ile anormal VEMP ve vHIT arasında anlamlı ilişki elde edilmemiştir. MS hastalarının vertigo, dizziness, bulantı, kusma gibi denge ile ilgili ciddi problemler yaşadıklarında tüm vestibüler değerlendirmenin yapılmasının yararlı olabileceği düşünülmektedir.Anahtar Kelimeler: Görüntüleme, multipl skleroz, vestibuler evoked myogenikpotansiyel, video head impulse test In our study, whether or not there was a peripheral vestibular end organ damage composed of vestibular nerve, utricle, saccule, and semicircular canals in cases diagnosed with relapsing-remitting MS was investigated by using the VEMP/vHIT test. The VEMP/vHIT findings of relapsing-remitting type of MS patients were compared with healthy subjects, the VEMP/vHIT parameters and brain magnetic resonance imaging (MRI) findings were investigated.For this purpose, a total of 50 individuals between the ages of 18 and 60 who were diagnosed with relapsing-remitting MS by a neurology physician at the Department of Neurology, Dışkapı Yıldırım Beyazıt Training and Research Hospital and 35 normal and healthy individuals in the same age group with normal hearing and without balance problems were included in the study. The sVEMP, oVEMP and vHIT tests used in the evaluation of the groups were performed in the Audiology Unit of the Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital. EDSS and magnetic resonance imaging findings of the MS group were evaluated by neurology physicians.As a result of the analysis of the data obtained from the study, the rates of obtaining oVEMP response in the MS group were significantly different from the control group, while there was no significant difference in terms of sVEMP responses. There was no significant difference between the two groups in terms of sVEMP/oVEMP mean latencies and vHIT gains. However, when the groups were compared in terms of sVEMP amplitudes, it was found to be significantly lower in the MS group. In the MS group, there was no significant correlation between brain stem-cerebellar symptoms, brain stem eye movement disorder symptoms, internuclear ophthalmoplegia, previous optic neuritic episode, duration of illness, EDSS score, total number of episodes and VEMP/vHIT. Incidence of abnormal oVEMP was significantly higher in the MS group than in the control group, whereas incidence of abnormal sVEMP and vHIT were not significant between groups. In MS group, no significant correlation was found between mesencephalon, bulbus, pons, cervical lesion and abnormal VEMP and vHIT according to lesion localization in MRI.It is thought that it may be useful to perform all vestibular evaluation, when MS patients have serious problems related to balance; such as vertigo, dizziness, nausea, and vomiting.Keywords: Imaging, multiple sclerosis, vestibular evoked myogenic potential, videohead impulse test 86
- Published
- 2018
125. Normal işiten sağlıklı yetişkinlerde ve sensörinöral işitme kayıplı hastalarda LS CE Chirp ve click uyaranları ile yapılan işitsel beyin sapı cevaplarının karşılaştırılması
- Author
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Dağaşar, Yeliz, Korkmaz, Mehmet Hakan, and Diğer
- Subjects
Hearing ,Evoked potentials-auditory-brain stem ,Ear diseases ,Hearing loss-sensorineural ,Hearing loss ,Audiology ,Otorhinolaryngology (Ear-Nose-Throat) ,Evoked potentials-auditory ,Kulak Burun ve Boğaz - Abstract
ABR odyolojik tanıda kullanılan bir testtir. ABR'de click, tone burst ve chirp uyaran kullanılmaktadır. Çalışmamızın amacı; normal işiten sağlıklı bireylerde ve SNİK işitme kayıplı hastalarda LS CE Chirp ve click uyaranları ile yapılan ABR 'nin V. dalga mutlak latans ve amplitüdlerinin karşılaştırılmasıdır. Çalışma 19-55 yaş arasındaki bireylerle yapılmıştır. Normal işiten 36 birey alınmıştır. Bilateral SNİK 'li 60 birey; hafif derecede SNİK'li 20, orta derecede SNİK'li 20, orta- ileri derecede SNİK 'li 20 birey şeklinde 3 gruba ayrılmıştır. Tüm bireylerin odyometrik ve timpanometrik değerlendirmeleri yapılmış ve önce click sonra da aynı cihazda parametre değiştirerek LS CE Chirp ABR testi yapılmıştır. Grupların tümünde; 90, 80, 60 dB şiddet düzeylerinde, ayrıca normal bireylerde 40 ve 20 dB şiddet seviyelerinde click ve LS CE Chirp uyaranları ile elde edilen V. dalga mutlak latans ve amplitüdleri karşılaştırılmıştır. LS CE Chirp ve click uyaranları ile V. dalga mutlak latans karşılaştımasında; sağlıklı bireylerde 90, 80 ve 20 dB şiddetlerinde anlamlı fark saptanmamış (p>0.05), 40 ve 20 dB şiddet düzeylerinde fark saptanmıştır (p0.05). Sağlıklı bireyler ve işitme kayıplı gruplarda tüm şiddet düzeylerinde amplitüdler LS CE Chirp uyaranda, click uyarandan anlamlı şekilde büyük elde edilmiştir (p0.05). The amplitude values of the LS CE Chirp responses were higher than the responses to click stimuli in all subject groups (p
- Published
- 2018
126. Prelingual ve postlingual işitme kayıplı bireylerde koklear implantın işitsel algı test sonuçları üzerine etkisinin değerlendirilmesi
- Author
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Bilgisu Erken, Şeyda, Korkmaz, Mehmet Hakan, and Diğer
- Subjects
Otorhinolaryngology (Ear-Nose-Throat) ,Kulak Burun ve Boğaz - Abstract
Bu çalışmada amacımız; prelingual ve postlingual dönemde işitme kaybı gelişmiş ve koklear implant uygulanan hastaların implantasyon öncesi ve sonrasında işitsel algı test sonuçlarının retrospektif olarak incelenmesidir. Dosyası incelenen 224 hastadan çalışmaya dahil edilme kriterine sahip 99 hastanın verileri değerlendirilmiştir. Hastalar öncelikle konjenital işitme kayıplı prelingual ve postlingual dönemde işitme kaybı gelişen hastalar olmak iki gruba ayrılmıştır. Prelingual 80 hasta ve postlingual 19 hastanın preoperatif ve postoperatif işitsel algı testleri karşılaştırılmıştır. Çalışmaya dahil edilen prelingual ve postlingual işitme kayıplı hastalar; cinsiyetleri, implantın uygulandığı taraf, uygulanan implantın markası, prelingual hastalar; implantasyon yaşları, akraba evliliği varlığı, implantasyon sonrası takip süreleri, operasyon öncesi işitme cihazlı serbest alan ortalamaları ayrıca postlingual işitme kayıplı hastalar işitme cihazı kullanım süreleri, tanı ile implantasyon arasında geçen süre açısından incelenmiş tüm bu parametrelerin preoperatif ve postoperatif işitsel algı test sonuçlarına etkileri değerlendirilmiştir Prelingual ve postlingual dönemde implante olan tüm hastalarda operasyon öncesi ve sonrası işitsel algı test sonuçlarında anlamlı fark bulunmuştur (p0.05). Prelingual ve postlingual hastalarda; cinsiyetin, uygulanan implantın taraf ve markasının, prelingual hastalarda; akraba evliliğinin, operasyon öncesi işitme cihazlı serbest alan ortalamalarının postlingual hastalarda ise işitme cihazı kullanım süresinin, tanı ile implant arasında geçen sürenin istatistiksel olarak anlamlı farka sebep olmadığı saptanmıştır (p>0.05). Prelingual hastalarda, implantasyon öncesi implantasyon yaşlarına göre 48 ay ve üzeri yaş grubunda Ling 6 ses testi, MTP ve MAIS envanterinde diğer yaş grupları ile istatistiksel olarak anlamlı fark bulunurken (p0.05). İmplantlandırma sonrası takip süresi açısından sadece MAIS envanterinde 24 aydan kısa ve uzun takiplerde anlamlı fark saptanmış (p 0.05). In prelingual and postlingual patients; it was found that the gender, the side and brand of the implant applied, and in patients with prelingual hearing loss, the consanguineous marriage, average of free range with hearing device in pre-operative period, and also duration of hearing aid usage in postlingual patients did not cause statistically any significant difference between diagnosis and implantation (p> 0.05).There was a statistically significant difference (p 0.05).In terms of the follow-up time after implantation, there was a significant difference only in the short and long follow-ups of 24 months in the Meaningful Auditory Integration Scale (MAIS) inventory (p
- Published
- 2017
127. Sağlıklı bireylerde farklı frekanslarda tone burst ve chirp uyaranları ile elde edilen servikal vestibüler uyarılmış myojenik potansiyellerin karşılaştırılması
- Author
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Çinar, Handan, Korkmaz, Mehmet Hakan, and Diğer
- Subjects
Vestibule ,Motion ,Equilibrium ,Vestibular nerve ,Ear ,Frequency ,Otorhinolaryngology (Ear-Nose-Throat) ,Evoked potentials ,Evoked potentials-auditory ,Kulak Burun ve Boğaz ,Vestibular diseases ,Vestibular function tests - Abstract
Çalışmamızda sağlıklı bireylerde farklı frekanslarda tone burst ve chirp uyaranları ile elde edilen cVEMP yanıtlarının saptanması ve bu bulguların karşılaştırılması hedeflenmiştir. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Klinik Araştırmalar Etik Kurulu'nun 22.03.2016 tarihli ve 27/04 sayılı kararı ile etik kurul açısından uygun bulunmuştur. Çalışma, 19-65 yaş arası toplam 65 gönüllü katılımcı ile gerçekleştirilmiştir. Çalışmamıza herhangi bir otolojik, nörootolojik ve vestibüler sistem ile ilgili şikâyet ve hastalığı olmayan, normal dış kulak yolu ve timpanik membrana sahip, elektroakustik immitansmetri değerlendirilmesinde, orta kulak basıncı ±50 daPa sınırlarında ve TipA timpanograma sahip ve saf ses ortalaması 125-8000 Hz arasında 15 dB ve daha iyi olan bireyler dâhil edilmiştir. VEMP'in ilk pozitif (P1) ve onu takip eden negatif dalgasının (N1) latansları ve bu iki dalganın tepe noktaları arasında kalan P1-N1 amplitüdleri ve VEMP Asimetri Oranı (VAR) karşılaştırılmıştır. 500 Hz Tone burst uyaran için; P1 latans ortalaması 12.89 ± 0.81 (ms), N1 latans ortalaması 21.13 ± 1.65 (ms), P1-N1 amplitüd değeri 104.99 ± 36.85 (µV)' dir. 500 Hz Frekansa-spesifik chirp uyaran için; P1 latans ortalaması 7,79 ± 0.86 (ms), N1 latans ortalaması 16.16 ± 1.67 (ms), P1-N1 amplitüd değeri 129.32 ± 41.25 (µV)' dir. 1000 Hz Tone burst uyaran için; P1 latans ortalaması 11.72 ± 0.85 (ms), N1 latans ortalaması 19.54 ± 1.62 (ms), P1-N1 amplitüd değeri 88.39 ± 29.65 (µV)' dir. 1000 Hz Frekansa-spesifik chirp uyaran için; P1 latans ortalaması 8.7 ± 0.88 (ms), N1 latans ortalaması 16.7 ± 1.75 (ms), P1-N1 amplitüd değeri 110.07 ± 35.77 (µV)'dir. İki farklı frekansta (500 ve 1000 Hz), chirp uyaran ile tone burst uyaran P1 (ms), N1 (ms) ve P1-N1 (µV) değerleri arasında istatistiksel olarak anlamlı farklılıklar bulunmuştur (p
- Published
- 2016
128. Benign paroksismal pozisyonel vertigoda vestibüler uyarılmış myojenik potansiyel (VEMP) ve video head ımpuls (VHIT)test bulguları
- Author
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Er, Serap, Korkmaz, Mehmet Hakan, and Odyoloji Ana Bilim Dalı
- Subjects
Vestibule ,Nystagmus ,Equilibrium ,Vertigo ,Otorhinolaryngology (Ear-Nose-Throat) ,Evoked potentials-auditory ,Kulak Burun ve Boğaz ,Vestibular diseases ,Vestibular function tests - Abstract
BPPV en yaygın periferik vestibüler sistem hastalığıdır. Kanalolitiazis ve kupulolitiasiz kabul edilen iki teoridir. BPPV'de vestibüler testlerin klinik önemi bilinmektedir. Çalışmamızda posterior kanal BPPV'de cVEMP, oVEMP ve vHIT bulguları incelenmiş ve Epley manevrasının bu testlerde oluşturduğu değişiklikler değerlendirilmiştir. Dışkapı Yıldırım Beyazıt Eğitim Araştırma Hastanesi KBB Kliniği'nde, yürütülen çalışmaya Dix-Hallpike testi (DHT) ile posterior kanal BPPV tanılı 36 hasta alındı. Otolojik ve nörootolojik hastalık hikâyesi olmayan 42 gönüllüden kontrol grubu oluşturuldu. Çalışma ve kontrol grubuna tedavi öncesi cVEMP, oVEMP ve vHIT'leri yapıldı. Testlerden sonra hasta gruba Epley manevrası uygulandı. Manevra sonrası iyileşme gözlenen hastalara testler tekrar edildi. cVEMP testinde; P1 ve N1 dalgaların latansları, P1-N1 amplitüdleri ve iki kulak arasındaki asimetri oranları analiz edildi. oVEMP testinde N1 ve P1 dalgaların latans ve amplitüdleri değerlendirildi. vHIT'de ise; infrared kamera kullanılarak etkilenen posterior kanaldaki kazançlar, tedavi sonrası ve normatif veriler ile karşılaştırıldı.cVEMP testinde tedavi öncesi ile sonrasındaki değerler kontrol grubuna göre karşılaştırıldığında P1ve N1 latanslarında anlamlı farklılık bulunmadı. Tedavi öncesi 84,75 μV ve sonrası 89,64 μV olan P1-N1 amplitüdü kontrol grubundaki 110,39 μV olan P1-N1amplitüdüne göre anlamlı şekilde düşük bulundu. (p
- Published
- 2016
129. OVEMP'te uygulanan farklı uyaranların ('KLİK', 'tone-burst', 'CHIRP') farklı yaş gruplarındaki sağlıklı bireyler üzerinde karşılaştırılması
- Author
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Baş, Banu, Korkmaz, Mehmet Hakan, and Kulak Burun Boğaz Ana Bilim Dalı
- Subjects
Vestibule ,Acoustic impedance tests ,Ear diseases ,Audiology ,Otorhinolaryngology (Ear-Nose-Throat) ,Evoked potentials-auditory ,Kulak Burun ve Boğaz ,Vestibular diseases ,Vestibular function tests - Abstract
ÖZEToVEMP'te Uygulanan Farklı Uyaranların ('klik', 'tone-burst', 'chirp') Farklı Yaş Gruplarındaki Sağlıklı Bireyler Üzerinde KarşılaştırılmasıÇalışmamız Dışkapı Yıldırım Beyazıt Eğitim Araştırma Hastanesi KBB kliniği odyoloji bölümünde gerçekleştirilmiştir. Dışkapı Yıldırım Beyazıt Eğitim Araştırma Hastanesi Etik Kurulu tarafından 22.03.2016 tarih ve 27/06 numaralı kurul kararı ile çalışmanın uygunluğuna karar verilmiştir.Çalışmamızda farklı yaş gruplarında normal işiten sağlıklı yetişkin kişiler de 'klik','chirp','tone-burst' uyaranlar ile elde edilen oVEMP yanıtlarının amplitüd ve latans açısından karşılaştırılması hedeflenmiştir.Çalışma 19-60 yaş arası 66 gönüllü ile gerçekleştirilmiştir. Çalışmaya daha önce vestibüler rahatsızlık yaşamamış, otoskopik muayene bulguları normal, hava yolu saf ses ortalaması (500-2000 Hz) 15 dB'den az olan,akustik immitansmetri sonuçlarında Tip A timpanogram elde edilen ve akustik refleks eşikleri normal olan bireyler dahil edilmiştir. Uygulama sırasında ortaya çıkan ilk negatif dalga (N1) devamında ortaya çıkan pozitif dalga (P1) latansları ve bu iki dalganın tepe noktaları arasında kalan (P1-N1) amplitüdleri karşılaştırılmıştır. Yapılan uygulamalar sonucu Chirp uyaran ile sağ kulak N1 5,9+/- 0,9 ms P1 11,06+/-0,92 ms P1-N1 10,51+/-7,2(μV);sol kulak N1 6,03+/-1,05ms P1 11,3+/-1,07ms P1-N1 11,93+/-7,33(μV) olarak elde edilmiştir. Klik uyaran ile sağ kulak N1 8,68 +/- 1,44 ms P1 12,73+/-1,8 ms P1-N1 2,77+/-2,05(μV); sol kulak N1 8,63+/-1,47ms P1 12,68+/-1,86ms P1-N1 2,86+/-1,94 olarak elde edilmiştir. Tone-burst uyaran ile sağ kulak N1 10,01+/-0,86 ms P1 14,89+/-1,21 ms P1-N1 7,09+/-5(μV) ; sol kulak N1 10,08+/- 0,88 P1 15,09+/-1,17 ms P1-N1 7,5+/-3,5(μV) olarak elde edilmiştir. Elde edilen N1(ms),P1(ms) ve P1-N1(μV) ortalamalarında her üç uyaran tipi arasında istatistiksel olarak anlamlı farklılıklar bulunmuştur.(p
- Published
- 2016
130. Comparisons of the oncological results of transoral laser surgery and radiotherapy for early stage laryngeal squamous cell cancer: single-center long-term results.
- Author
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Doluoglu S, Bayir O, Ocal B, Tatar EC, Korkmaz MH, and Saylam G
- Subjects
- Humans, Male, Female, Retrospective Studies, Middle Aged, Disease-Free Survival, Aged, Laryngectomy methods, Treatment Outcome, Survival Rate, Adult, Follow-Up Studies, Laryngeal Neoplasms radiotherapy, Laryngeal Neoplasms pathology, Laryngeal Neoplasms surgery, Laryngeal Neoplasms mortality, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell mortality, Laser Therapy methods, Neoplasm Recurrence, Local, Neoplasm Staging
- Abstract
Background: In the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used., Objectives: Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT., Design: Retrospective., Settings: Tertiary training and research hospital., Patients and Methods: The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS)., Main Outcome Measures: The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers., Sample Size: 261., Results: The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group ( P =.034, .065, .269, .060, respectively)., Conclusions: TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups ( P =.034)., Limitations: Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.
- Published
- 2024
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131. Which Mask, N95 or Surgical Mask, Causes Hoarseness in Healthcare Workers?
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Altan E, Barmak E, Tatar EÇ, Saylam G, and Korkmaz MH
- Abstract
Objectives: This study aimed to determine the impact of different types of masks on the voices of healthcare professionals who had to wear masks for an extended amount of time during the pandemic period and had a healthy voice., Methods: Our research included 41 healthcare workers. The participants were separated into two groups: surgical (n = 21) and N95 mask users (n = 20). Healthcare workers evaluated masks before and after wearing them for at least 8 hours throughout the workday. All subjects had a videolaryngoscopic examination; the Voice Handicap Index-10 (VHI-10), GRBAS, acoustic voice analysis (F0, jitter%, shimmer%, noise/harmonic ratio, relative average perturbation [RAP]), aerodynamic measures (maximum phonation time, MPT), and blood oxygen saturation were evaluated., Results: Although both groups' VHI-10 scores increased after using the mask, this rise was not statistically significant in our research. According to the GRBAS classification, voice quality deterioration was identified in 9.6% (mild-moderate) of the group using surgical masks and 15% (mild) of the group wearing N95. Only the jitter and RAP values of individuals wearing both surgical and N95 masks were determined to be statistically significant. There was no significant change in MPT following mask wear in either group. Both the surgical and N95 mask-using groups showed a substantial drop in blood oxygen saturation before and after mask usage., Conclusion: There was no change in voice quality between healthcare workers wearing surgical and N95 masks. It has been noticed that voice perception and quality are affected by the mask's barrier effect rather than the kind of mask., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2024
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132. Online Training or Face-to-Face Training from the Perspective of Ear, Nose, and Throat and Head and Neck Surgeons?
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Kaya Çelik E, Doluoğlu S, Güzelküçük Akay H, Çadalli Tatar E, and Korkmaz MH
- Abstract
Purpose: To determine the preferences of Ear, Nose, and Throat (ENT) and Head-Neck Surgery (HNS) specialists and residents undergoing training for online or face-to-face training and the factors affecting the preference., Methods: An 16-item questionnaire was created using Google Forms and was administered to residents undergoing training in ENT departments and to specialists working in the same field. The questionnaires were distributed online and requested to be completed between August and October 2020. The study participants were analyzed in two groups according to the preference for online training or face-to-face training., Results: Evaluation was made of a total of 173 participants, as 68 (39.3%) in online training, and 105 (60.7%) in face-to-face training. Online training comprised 47 (69.1%) females and 21 (30.9%) males with a mean age of 38.9 ± 8years and face-to-face training comprised 68 (64.8%) females and 37 (35.2%) males with a mean age of 37.9 ± 7.5years (gender: P = 0.55, age: P = 0.10). Of the total sample, 39 (22.5%) subjects were single and 134 (77.5%) were married. Face-to-face training was preferred by 61.2% of the married respondents and by 59% of those who were single. While 43.4% stated that visuals and documents were similar in both forms of training, those who stated that documentation was better in face-to-face training constituted 90.2% of the group that preferred face-to-face training (P = 0.0001). Of the total participants, 65.4% stated that concentration was easier in face-to-face training (P = 0.0001). When the groups were compared according to areas of interest, more of those involved in rhinology and head-neck surgery were in face-to-face training, and those with an interest in otology were seen to be in online training (P = 0.002). A wish to continue online training after the pandemic was expressed by 80.9% of the whole sample, and 68.6% wished to continue with face-to-face training (P = 0.0001). Hybrid meetings were determined to have been selected by 86.1% (P = 0.0001)., Conclusion: Online web seminars have an important role as a teaching and learning tool. There is a need for further research to evaluate how these clinically focused seminars can be presented at high quality and how they can provide benefit in training., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2024
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133. Novel clinical screening method to identify patients at risk of obstructive sleep apnea.
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Günay MM, Saylam G, Fırat İH, Akyıldız İ, Bayır Ö, Mutlu M, and Korkmaz MH
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- Humans, Polysomnography methods, Physical Examination, Sleep Apnea, Obstructive diagnosis
- Abstract
Objective: To investigate whether the distance between the two retromolar trigones (RMTs) with the distance between the two posterior plicas (PPs) affects obstructive sleep apnea syndrome (OSAS) and to determine a physical examination method that can be used in the selection of patients to be referred to polysomnography (PSG)., Methods: The study included 86 OSAS patients and 29 healthy controls. RMTs and PPs were measured using a caliper-like device. The values obtained from these measurements were evaluated in both groups., Results: The PPs were narrower, and the RMTs-PPs, RMTs-PPs/RMTs, and RMTs/PPs values were greater in the OSAS group ( p < .05) compared to the control group. The cut-off values were 0.612 for RMTs-PPs/RMTs and 2.589 for RMTs/PPs. The specificity of these values for OSAS was 97%, and sensitivity was 57% and 58%, respectively., Conclusion: The presented method may play a role in preventing unnecessary PSG among patients with suspected OSAS.
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- 2024
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134. Can Cochlear Nerve Size Assessment With Magnetic Resonance Enhance the Understanding of Idiopathic Sudden Sensorineural Hearing Loss?
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Arslan H, Özdemir M, Kavak RP, Keseroğlu K, Mutlu M, and Korkmaz MH
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Background and Objectives: Idiopathic sudden sensorineural hearing loss (ISSHL) is a rapid loss of hearing, exceeding 30 dB in at least 3 consecutive frequencies within 3 days, without any identifiable cause despite thorough investigations. Currently, the etiology and pathogenesis of ISSHL have not been fully elucidated. This study aimed to assess the size of the cochlear nerve in patients with ISSHL and explore its relationship with pretreatment audiograms and treatment response. Subjects and., Methods: A total of 125 patients (59 [47.2%] women; mean age 47.7±13.8 years [minimum-maximum: 21-76]) and 60 healthy participants (27 [45%] women; mean age 45.7±16.8 years [minimum-maximum: 20-76]) as a control group were included in this study. The size of the cochlear nerve was assessed on the affected side, compared to the control group, as well as on the unaffected side. Pretreatment and posttreatment audiological values were also analyzed., Results: The cross-sectional area (CSA), vertical diameter (VD), and horizontal diameter (HD) of the CN were found to be smaller on the affected side of ISSHL patients compared to the control group (p<0.01; p=0.04; p=0.02, respectively). In the study group (affected side of ISSHL patients), there were no significant differences in VD, HD, and CSA values between pretreatment audiogram types (p=0.23; p=0.53; p=0.39, respectively), and initial hearing levels (p=0.16; p=0.22; p=0.23, respectively). Furthermore, there were no significant differences in VD, HD, and CSA values between the recovery groups according to Furuhashi criteria (p=0.18; p=0.37; p=0.27, respectively)., Conclusions: The size of the CN may be a risk factor for ISSHL, but it does not affect the type of audiogram curves and was not prognostic in terms of treatment response.
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- 2024
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135. Impact of the Severity of Reinke's Edema on the Parameters of Voice.
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Barmak E, Altan E, Yılmaz Z, Korkmaz MH, and Çadallı Tatar E
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Objective: This study aimed to classify the degree of edema in patients with Reinke's edema (RE) and examine its impact on their voice parameters using both objective and subjective assessment methods., Methods: Objective and subjective voice data of 104 patients diagnosed with RE between 2018 and 2021 were evaluated retrospectively. RE is classified into 4 groups (types 1, 2, 3, and 4). The evaluation included videolaryngostroboscopic examination, acoustic voice analysis, and aerodynamic measurements, GRBAS, Voice Handicap Index-10 (VHI-10), Voice-Related Quality of Life Scale (V-RQOL), and Reflux Septum Index (RSI)., Results: Patients with type 1 RE had a significantly lower mean age than those with types 3-4. Although there were no significant differences in acoustic and aerodynamic parameters between the groups, it was observed that F0 and the maximum phonation time decreased as the degree of edema increased. The GRBASTotal, G, and R scores of types 1 and 2 were significantly lower than those of types 3 and 4, as were the scores of type 1 S. There were no statistically significant differences between the RE groups in terms of VHI-10, V-RQOL, and RSI scores., Conclusion: It has been observed that as the severity of RE increases, voice perception and quality (especially types 3 and 4) are negatively affected. Determining the degree of edema will guide the clinician in both the planning of the intervention phase and the follow-up phase., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare., (©Copyright 2023 by Turkish Otorhinolaryngology-Head and Neck Surgery Society / Turkish Archives of Otorhinolaryngology is published by Galenos Publishing House.)
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- 2023
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136. Metastatic diffuse follicular variant papillary thyroid cancer without cervical lymph node metastasis presenting with symptoms related to hypopituitarism.
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Kızılgül M, Bayır Ö, Uçan B, Akhanlı P, Düğer H, Sencar ME, Kertmen H, Yılmazer D, Yazılıtaş D, Saylam G, Korkmaz MH, and Çakal E
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- Male, Humans, Aged, Thyroid Cancer, Papillary complications, Thyroid Cancer, Papillary surgery, Lymphatic Metastasis, Sorafenib, Iodine Radioisotopes, Thyroidectomy methods, Thyroid Neoplasms complications, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms pathology, Hypopituitarism diagnostic imaging, Hypopituitarism etiology, Hypopituitarism surgery
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In this article, we present a case of diffuse follicular variant papillary thyroid carcinoma with pituitary metastasis, which is a rare cause of pituitary metastasis. The follicular variant of papillary thyroid carcinoma is an uncommon variant of papillary carcinoma. A 74-year-old male was presented with weakness, fatigue, and a decreased appetite. The patient was diagnosed with secondary adrenal and thyroid insufficiencies. Imaging revealed a pituitary mass with suprasellar extension, right cavernous sinus invasion, and optic chiasm compression. Thyroid ultrasonography revealed a nodule with a maximum size of 7.2cm in the right lobe. Cytological examination via fine-needle aspiration suggested papillary thyroid cancer. Total thyroidectomy with central and right lateral neck dissection confirmed the diagnosis of diffuse follicular variant of papillary thyroid carcinoma. Owing to visual field defects, the patient underwent transsphenoidal surgery. Histological and immunohistochemical evaluations confirmed pituitary metastasis from the papillary thyroid cancer. Radioactive iodine treatment and gamma knife radiotherapy of the pituitary gland were performed. The initiation of sorafenib treatment was deemed appropriate during the follow-up. A significant decrease in the thyroglobulin levels was observed after sorafenib treatment. Pituitary metastasis should be considered in patients diagnosed with hypopituitarism and pituitary lesions at initial evaluation. The presence of visual field defects may be an indication for neurosurgical intervention and guide both diagnosis and treatment. The management of papillary thyroid cancer and the role of treatment modalities in prognosis depend on the biological behavior of the tumor. Early diagnosis and multidisciplinary management are crucial for the treatment of these patients.
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- 2023
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137. Outcomes of Chemotherapy plus Cetuximab as First-line Treatment in Patients with Metastatic, Recurrent, Unresectable Head and Neck Cancers: Real-life Data.
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Yazilitas D, Sahinli H, Saylam G, Imamoglu GI, Korkmaz MH, and Bayir O
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- Humans, Male, Female, Cetuximab therapeutic use, Cetuximab adverse effects, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local pathology, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols, Head and Neck Neoplasms drug therapy, Carcinoma, Squamous Cell pathology
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Objective: To examine the treatment outcomes of the EXTREME regimen as the first-line therapy for recurrent/metastatic squamous cell carcinoma of the head and neck., Study Design: Observational study. Place and Duration of the Study: Department of Medical Oncology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Turkiye, between January 2014 and December 2021., Methodology: A total of 60 patients with recurrent/metastatic head and neck cancers were treated with EXTREME regimen. Survival curves were estimated using the Kaplan-Meier method. Cox proportional hazards regression models were used to determine the factors associated with progression-free survival (PFS) and overall survival (OS)., Results: Patients receiving cetuximab in combination with chemotherapy for metastatic or unresectable disease were obtained from patient files and electronic medical records. Majority of patients were male (78.3%). The median PFS of patients was 7 months. The median survival of the patients was 9.06 months. During follow-up, 55 patients (91.7%) relapsed, and 51 patients (85%) died. The median survival of patients with eastern cooperative oncology group (ECOG) performance status 0, 1, and 2 was 16, 9, and 4 months, respectively. And the survival of patients was found significantly lower with lower ECOG performance scores., Conclusion: OS was determined as 9.06 months. ECOG performance score had an important effect on the survival., Key Words: Cetuximab, Head and neck cancer, Chemotherapy.
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- 2023
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138. Management of deep neck infections in adults and importance of clinical and laboratory findings.
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Arslan H, Bayır Ö, Aksoy Ş, Keseroğlu K, Saka C, Tatar EÇ, Saylam G, and Korkmaz MH
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- Adult, Anti-Bacterial Agents therapeutic use, Blood Sedimentation, Female, Humans, Male, Middle Aged, ROC Curve, Retrospective Studies, Young Adult, C-Reactive Protein, Drainage
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This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38.2±14.5 years) were included in the study. Patients were divided into three groups according to the treatment strategy: group 1 received only antibiotic treatment, group 2 underwent abscess drainage with needle puncture in addition to antibiotic treatment, and group 3 underwent surgical drainage with antibiotic treatment. Laboratory outcomes, imaging methods, duration of hospital stay, treatment strategy, and clinical outcomes were analyzed.According to the laboratory results, complete blood count values did not vary among the three groups, but C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were higher in group 3 (p<0.01). Based on receiver operating characteristic (ROC) analysis, the cut-off levels for CRP and ESR associated with the need for surgical drainage were 133 mg/L and 42.5, respectively. According to radiological imaging results, the number of involved neck spaces was significantly different among the three groups (p=0.03), and group 3 had more spaces involved when compared with groups 1 and 2 (p=0.04). Gas formation in the neck tissues was noted in 10 patients in group 3 and 5 patients in groups 1 and 2 (p=0.02). ESR and CRP levels were higher in patients who underwent surgical drainage. In patients with deep neck space infections, the involvement of two or more neck spaces and gas formation on radiological images might indicate surgical drainage as a treatment strategy., Competing Interests: Competing interests: None declared., (© American Federation for Medical Research 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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139. Prognostic and Clinical Role of Contrast Enhancement on Magnetic Resonance Imaging in Patients with Bell's Palsy.
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Yücel V, Özbal Güneş S, Keseroğlu K, Bayır Ö, Çırakoğlu MF, Çadallı Tatar E, Saylam G, Karahan S, Yılmaz O, and Korkmaz MH
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Objective: To investigate the prognostic value of the magnetic resonance imaging in Bell's palsy patients., Methods: Patients who were diagnosed and treated with Bell's palsy between October 2013 and March 2016 retrospectively selected. House-Brackmann grades, pre- and post-treatment pure tone audiograms, stapedial reflexes were analyzed and magnetic resonance imaging (MRI) scans with gadolinium-based contrast agents were evaluated. Contrast-enhanced segments of the facial nerve were determined. MRI findings were compared statistically with pre- and post-treatment grade, recurrence rate of Bell's palsy, MRI scanning timing, presence of stapes reflexes and posttreatment recovery data., Results: No significant correlation was observed between pretreatment House-Brackmann grades and enhancement (p>0.05). Similarly, there was no significant correlation between clinical recovery and enhancement (p>0.05). Also, no significant correlation was observed between MRI scanning time, the recurrence rate of Bell's palsy and MRI findings (p>0.05). None of the MRIs showed neoplastic contrast enhancement., Conclusion: The routine use of the contrast-enhanced temporal MRI is not recommended in the diagnosis and monitoring of Bell's palsy patients, because the contrast enhancement pattern of the facial nerve has no effect on the prognosis of Bell's palsy. MRI should be used in cases that do not heal despite treatment, for the differential diagnosis of facial nerve tumors and in patients who are candidates for surgical decompression., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare., (©Copyright 2022 by Official Journal of the Turkish Society of Otorhinolaryngology and Head and Neck Surgery.)
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- 2022
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140. How important is the Sphenoseptal cell in identifying the skull base? Recent incidence and demonstration of endoscopic surgical steps
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Saka C, Öcal B, Çadallı Tatar E, Toptaş G, Pütürgeli Özer T, and Korkmaz MH
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- Female, Humans, Retrospective Studies, Tomography, X-Ray Computed, Endoscopy methods, Skull Base diagnostic imaging, Skull Base surgery, Sphenoid Sinus diagnostic imaging, Sphenoid Sinus surgery
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Background/aim: Because of close relations to important anatomical structures such as cavernous sinus and optic nerve, sphenoid sinus variations must be well trained by the otolaryngologist who has an interest in endoscopic sinus surgery. Newly defined sphenoseptal cell (SSC) is one of those variations that may lead to insufficient endoscopic sinus surgery outcomes if not defined preoperatively with imaging studies. The present study aimed to present the main characteristics of this special type of nasal cell., Materials and Methods: In this study, 610 paranasal sinus CT scans were analyzed and reviewed retrospectively between May 2018 and December 2019. Also, endoscopic findings of SSC that cause a surgical catastrophe in identifying skull base and sella are presented during transnasal transsphenoidal pituitary surgery., Results: According to its definition and relation to the sphenoid sinus and the skull base, an SSC was seen in 21 scans of 610 patients (3.4%), 11 were women (55%) and 10 were men (45%)., Conclusion: Although an SSC is a rare variation of nasal air cells, preoperative diagnosis of this cell is of paramount importance in some patients during endoscopic transnasal surgery for the identification of skull base., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2021
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141. Multifrequency multicomponent tympanometry in children with a history of ventilation tube insertion.
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Kaya S, Keseroglu K, Tokgoz SA, Barmak E, Saylam G, and Korkmaz MH
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- Case-Control Studies, Child, Ear, Middle, Humans, Prospective Studies, Acoustic Impedance Tests, Middle Ear Ventilation
- Abstract
Objectives: To use multifrequency multicomponent tympanometry (MF-MCT) for evaluating the middle ear mechano-acoustics of children with a history of ventilation tube (VT) insertion and to determine the effects of tube insertion sequelae on middle ear function., Methods: A prospective case-control study in a tertiary referral center involving 26 children (51 ears) aged 3-15 years. The children had undergone VT insertion surgery at least one-year previously and had no other known ear diseases. In addition, 13 age-matched healthy controls (26 ears) with no prior history of ear disease were included. The patients and control subjects underwent an otoscopic examination, standard 226 Hz tympanometry, and MF-MCT., Results: In 13.7% of cases, the VT was still in place in the operated ears. Post-operative myringosclerosis and/or eardrum retraction were noticed in 30% of ears with intact tympanic membranes in the patient group. While patients exhibited a great variability of tympanometric types (with standard 226 Hz tympanometry and tympanometric patterns with 1000 Hz MF-MCT), all cases in the control group had type A tympanograms and 3B1G patterns., Conclusion: The effects of VT treatment on the mechano-acoustics of the middle ear have been revealed in this study. It has also been determined that VT application may increase the mass effect on the middle ear functions, which can be detected in the tympanometric shape and pattern., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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142. Impact of fetal brain tissue derived mesenchymal stem cell and fibrin glue on facial nerve crash injury
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Bayır Ö, Karagöz T, Alpaslan Pınarlı F, Sarıbaş GS, Özoğul C, Keseroğlu K, Saylam G, Çadallı Tatar E, Karahan S, Öcal B, and Korkmaz MH
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- Animals, Brain, Bromodeoxyuridine, Facial Nerve, Fibrin Tissue Adhesive, Rats, Rats, Sprague-Dawley, Mesenchymal Stem Cells
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Background/aim: To evaluate the clinical and histopathological effects of fetal brain tissue derived mesenchymal stem cells (FBTMSC) and fibrin glue (FG) on the facial nerve (FN) regeneration in rats with traumatic FN injury., Materials and Methods: Twenty-eight Sprague Dawley rats were included in the study and divided into 4 groups. Traumatic FN injury (FP) was created by a surgical clamp compression to the main trunk of left FN in all groups. In the control group (group 1) no treatment was applied, in group 2 (FBTMSC group) 2 × 106 FBTMSC was injected, in group 3 (FG group) only FG was applied, in group 4 (FBTMSC and FG groups) both FBTMSC and FG were applied to the injured section of the nerve. The FN functions were evaluated clinically, immediately after the procedure and at 3rd, 5th, and 8th weeks postoperatively. The FNs of all subjects were excised after the 8th week; then the rats were sacrificed. The presence of stem cells in the injured zone was assessed using bromo-deoxyuridine (BrdU), and apoptosis was determined by the TUNEL method., Results: After the damage, total FP was observed in all subjects. Statistically significant functional improvement was observed in group 4 compared to all other groups (P < 0.005). TUNEL-positive cell count was statistically significantly higher in the control group than the other groups (P < 0.001). TUNEL-positive cell count was statistically significantly lower in group 4 than the other groups. The proportion of BrdU-stained cells in group 4 (5%) was higher than group 2 (2%)., Conclusion: Clinically and histopathologically FBTMSC applied with FG may play a promising role as a regenerative treatment in posttraumatic FP., Competing Interests: No conflict of interest was declared by the authors., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2021
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143. Is There Any Effect of Subjective Tinnitus on Vestibular Evoked Myogenic Potentials.
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Toptas G, Keseroğlu K, Öcal B, Saka C, Er S, and Korkmaz MH
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- Cochlea, Humans, Tinnitus diagnosis, Vestibular Evoked Myogenic Potentials
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Idiopathic subjective tinnitus has a complex pathophysiology in which not only cochlear and central classical auditory pathways but also nonclassical auditory pathways of different parts of the brain are involved. Vestibuloocular and vestibulocollic pathways are the central projections of utricle and saccule used in the vestibular evoked myogenic potential (VEMP) test. Aim of this study was to investigate the effects of idiopathic subjective tinnitus on vestibuloocular and vestibulocollic pathways via VEMP. We prospectively analyzed 30 unilateral idiopathic subjective tinnitus patient's cervical, ocular VEMP tests, tinnitus handicap index scores, symptom duration and compared with contralateral ear and 35 healthy volunteers. The latencies and amplitudes of P1 and N1 waves were recorded and pathologic wave criteria was calculated according to healthy volunteer's data. In cervical VEMP there were significant longer latencies of P1 and N1 waves with respect to contralateral ear and control group. In ocular VEMP test, N1 and P1 latencies and amplitudes were not significantly different. The percentages of pathologic wave of the tinnitus side were not significantly higher in both cervical VEMP and ocular VEMP tests with respect to contralateral side. Tinnitus handicap index scores and symptom duration had no relationship with latency and amplitude of VEMP tests. Although cervical VEMP P1 and N1 latencies were significantly longer, subjective tinnitus did not result in pathological alterations in the VEMP test. Presence of subjective tinnitus is not an influencing factor in the VEMP interpretation.
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- 2021
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144. Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome.
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Ulusoy B, Oğuzhan T, Akyol M, Bozdemir K, Çiftçi B, and Korkmaz MH
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- Adult, Case-Control Studies, Female, Humans, Male, Mean Platelet Volume, Middle Aged, Platelet Count, Prospective Studies, Severity of Illness Index, Blood Platelets physiology, Continuous Positive Airway Pressure methods, Platelet Activation physiology, Sleep Apnea, Obstructive blood, Sleep Apnea, Obstructive therapy
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Background: To analyze the association between obstructive sleep apnea syndrome (OSAS) and some hematological variables such as mean platelet volume (MPV), platelet distribution width (PDW), and the impact of positive airway pressure (PAP) treatment on these parameters., Methods: The participants of the present prospective study consist of 36 OSAS patients diagnosed with polysomnography and recommended PAP treatment and 30 healthy members as the control group. Complete blood analyses were conducted to the patient group twice; before the initiation of the PAP treatment and 1 month after regular PAP use. The control group was administered a complete blood analyses only once. Patient and control group were compared in terms of various parameters such as MPV, PDW, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) values, and platelet counts., Results: MPV value of the patient group was before and after PAP treatment significantly higher than the control group (respectively; Z = 2.246; p = 0.025, and Z = 2.033; p = 0.042). However, there were no statistically significant differences in the values before and after PAP treatment in the patient group (Z = 0.727; p = 0.467). In terms of platelet numbers and PDW values, no significant differences were determined (p > 0.05)., Conclusion: MPV value was significantly elevated in OSAS patients. However, the 1 month of PAP treatment was insufficient in decreasing elevated MPV values.
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- 2020
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145. The effects of choanal atresia on development of the paranasal sinuses and turbinates.
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Terzi S, Dursun E, Çeliker FB, Çeliker M, Beyazal M, Özgür A, Tatar EÇ, and Korkmaz MH
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- Adolescent, Adult, Female, Humans, Male, Retrospective Studies, Choanal Atresia complications, Choanal Atresia diagnostic imaging, Paranasal Sinuses diagnostic imaging, Paranasal Sinuses growth & development, Tomography, X-Ray Computed, Turbinates diagnostic imaging, Turbinates growth & development
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Purpose: The objective of this study was to evaluate the volume of paranasal sinuses (PNS) and turbinate in patients with unilateral choanal atresia (CA)., Materials and Method: Computed tomography images of PNS in 11 individuals with unilateral CA were evaluated retrospectively. Mucosal thickness and volume of the maxillary, frontal and sphenoidal sinuses were determined, in addition to the volume of the middle and inferior turbinate. The unaffected nasal side of patients was used as a control group for the measurements. The results comprised the measurements of the atresic side compared to those of the healthy side., Results: There was no significant difference between the atresic and healthy side of the nose in patients with CA with respect to mucosal thickness and volume of the PNS (the maxillary, frontal and sphenoidal sinuses) and the middle and inferior turbinate (p > 0.050)., Conclusion: The complete absence of nasal unilateral airflow had no effect on the development of the PNS and the middle and inferior turbinate. Moreover, mucosal thickness in the sinuses was similar to that in the control group.
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- 2017
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146. Stentless endoscopic repair of congenital choanal atresia: is it enough for maintaining choanal patency?
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Tatar EÇ, Öcal B, Doğan E, Bayır Ö, Saka C, Özdek A, and Korkmaz MH
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- Adolescent, Child, Preschool, Female, Humans, Infant, Newborn, Male, Middle Aged, Reoperation methods, Treatment Outcome, Choanal Atresia surgery, Constriction, Pathologic diagnosis, Constriction, Pathologic etiology, Natural Orifice Endoscopic Surgery adverse effects, Natural Orifice Endoscopic Surgery instrumentation, Natural Orifice Endoscopic Surgery methods, Nose abnormalities, Nose diagnostic imaging, Nose surgery, Postoperative Complications diagnosis, Postoperative Complications surgery, Stents
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The aim of choanal atresia (CA) surgery is to achieve bilateral nasal patency. Among the different methods of CA repair, the endoscopic transnasal approach has gained recent popularity with the advent of endoscopic instruments and techniques. This article describes our experience regarding CA repair that was done either using or not using a stent in different periods of time in our department. Between February 2006 and February 2016, a total of 29 patients aged 2 days-53 years underwent endoscopic transnasal CA repair. While in early years stents were used to maintain nasal patency, since 2010, all cases were repaired endoscopically without stenting. Of the 29 patients, 8 were excluded because of inadequate follow-up data. The mean follow-up time for the remaining 21 patients after surgery averaged 53 months (range 12-111 months). Intranasal stents were used in 5 of 21 patients for 8 out of 32 operative sides. Of the 8 stented neochoanae, 6 (75%), restenosed at a mean time of 15.2 weeks (5-24). The restenosis rate was 25% (6/24 nasal sides) in 16 patients who underwent stentless repair. In unilateral CA, 2 of 10 (20%) patients underwent atresia repair using stents and only these cases restenosed after surgery in this group. Of the 11 patients with bilateral disease, 5 (45.4%) underwent revision surgeries. In the bilateral group, 2 of 3 (66.6%) stented patients required revision surgeries, whereas 3 of 8 (37.5%) patients who underwent stentless repair relapsed. In one patient, we have experienced an alar cartilage injury intraoperatively caused by drilling. The transnasal endoscopic repair has proved to be effective and yielded long-term satisfactory results. The use of stent seems to have no advantage over a stentless repair regarding maintenance of a patent nasal airway. Patients experienced restenosis more frequently with stenting.
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- 2017
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147. The effects of the stem cell on ciliary regeneration of injured rabbit sinonasal epithelium.
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Kavuzlu A, Tatar EÇ, Karagöz T, Pınarlı FA, Tatar İ, Bayır Ö, and Korkmaz MH
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- Adipose Tissue cytology, Animals, Male, Maxillary Sinus pathology, Maxillary Sinus physiopathology, Maxillary Sinus surgery, Models, Animal, Nasal Surgical Procedures, Rabbits, Treatment Outcome, Cilia physiology, Mesenchymal Stem Cell Transplantation methods, Mesenchymal Stem Cells physiology, Nasal Mucosa injuries, Nasal Mucosa pathology, Nasal Mucosa physiopathology, Wound Healing physiology
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Defects in mucosal healing after sinonasal surgery cause infection, scar formation causing obstruction, relapse of the disease within a shorter period and revision surgery. The present study aimed to create a functional ciliated epithelium using a stem cell and stem cell sheet of adipose tissue origin and to show such regeneration ultra-structurally on experimentally injured rabbit nasal epithelium. This was an experimental animal study and basic research. A total of 18 white New Zealand rabbits were divided into three groups. The medial wall of the maxillary sinus of the subjects was peeled off bilaterally. No additional procedure was applied to the subjects in Group 1. In Group 2, adipose tissue-derived mesenchymal stem cell was implanted on the wound edges of the subjects. In Group 3, a stem cell sheet of three layers was laid onto the defect area. All subjects were killed after 3 weeks. The presence of the stem cell stained with bromo-deoxyuridine was assessed with a light microscope, whereas cilia density, ciliated orientation and cilia structure were evaluated with a scanning electron microscope. Ciliary densities in Group 2 and Group 3 were statistically superior compared to the control group (p < 0.001, p = 0.007). Cilia morphology in Group 2 and Group 3 was also better than the control group (p < 0.01, p = 0.048). Ciliary orientation in Group 2 was scored highest (p < 0.01). The ratio of BrDu-stained cells was observed to be 27% in Group 3 and 8% in Group 2. Sub-epithelial recovery was observed to be better in Group 3. Adipose tissue-derived mesenchymal stem cell increased the healing of the injured maxillary sinus mucosa of the rabbits in terms of cilia presence, density and morphology regardless of the implementation technique. Level of evidence NA.
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- 2017
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148. Protective/restorative Role of the Adipose Tissue-derived Mesenchymal Stem Cells on the Radioiodine-induced Salivary Gland Damage in Rats.
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Saylam G, Bayır Ö, Gültekin SS, Pınarlı FA, Han Ü, Korkmaz MH, Sancaktar ME, Tatar İ, Sargon MF, and Tatar EÇ
- Abstract
Background: To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on
131 I-Radioiodine (RAI)-induced salivary gland damage in rats., Materials and Methods: Study population consisted of controls (n:6) and study groups (n:54): RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI+amifostine (Group 4), concomitant RAI+ADMSC (Group 5) and RAI+ADMSC after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM), and salivary gland scintigraphy (SGS), and analyzed data statistically., Results: We observed the homing of ADMSC in salivary glands at 1st month on LM. RAI exposure affected necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and the total sum score were in a statistically significant manner ( P < 0.05). Intragroup comparisons with LM at 1st and 6th months revealed statistically significant improvements in Group 6 ( P < 0.05) but not in Groups 4 and 5. Intergroup comparisons of the total score showed that Groups 4 and 5 in 1st month and Group 6 in 6th month had the lowest values. TEM showed vacuolization, edema, and fibrosis at 1st month, and an improvement in damage in 6th month in Groups 5 and 6. SGSs revealed significant differences for the maximum secretion ratio (Smax) ( P = 0.01) and the gland-to-background ratio at a maximum count (G/BGmax) ( P = 0. 01) at 1st month, for G/BGmax ( P = 0.01), Smax ( P = 0.01) and the time to reach the maximum count ratio over the time to reach the minimum count (Tmax/Tmin) ( P = 0.03) at 6th month. 1st and 6th month scans showed differences for Smax and G/BGmax ( P = 0.04), but not for Tmax/Tmin ( p > 0.05). We observed a significant deterioration in gland function in group 1, whereas, mild to moderate deteriorations were seen in protective treatment groups., Conclusions: Our results indicated that ADMSC might play a promising role as a protective/regenerative agent against RAI-induced salivary gland dysfunction., Competing Interests: Disclosure: No potential conflicts of interest were disclosed.- Published
- 2017
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149. Laryngeal electromyographic changes in postthyroidectomy patients with normal vocal cord mobility.
- Author
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Keseroglu K, Bayir O, Umay EK, Saylam G, Tatar EC, Ozdek A, and Korkmaz MH
- Subjects
- Adult, Aged, Female, Follow-Up Studies, Humans, Laryngeal Muscles innervation, Laryngeal Muscles physiopathology, Laryngeal Nerve Injuries etiology, Laryngeal Nerve Injuries physiopathology, Male, Middle Aged, Outcome Assessment, Health Care, Postoperative Complications physiopathology, Prospective Studies, Risk Factors, Vocal Cords physiology, Electromyography methods, Laryngeal Nerve Injuries diagnosis, Postoperative Complications diagnosis, Thyroidectomy adverse effects
- Abstract
Thyroidectomy has been used for the treatment of thyroid disease for more than 100 years. In spite of the advancement of surgical techniques, there is still a risk of laryngeal nerve injury. The risk of partial or complete injury still depends on some surgical and disease-related factors. The aim of this study is to show the partial injury and to establish these risk factors via laryngeal electromyographic analysis (LEMG) in postthyroidectomy patients with normal vocal cord motion and mucosal anatomy. Patients who had undergone thyroid surgery were enrolled in this prospective study. LEMG analysis was performed to all patients with normal vocal cord mobility preoperatively and was repeated after the first and the third months of surgery. Thyroarytenoid (TA) and cricothyroid (CT) muscles were used to evaluate recurrent and external branch of superior laryngeal nerves, respectively. Four of the 32 patients had mild-to-moderate degrees of partial LEMG changes during preoperative LEMG analysis of TA and CT muscles on each side. After 3 months of surgery, there was a statistically significant worsening of LEMG findings in the right and left external branches of superior and left recurrent laryngeal nerves. Disease and surgery-related risk factors were analyzed. However, there was no significant relationship on the progression of LEMG findings according to these parameters. This is the first prospective study which supports the risk of progression of LEMG changes in patients with normal laryngoscopic examination after thyroid surgery. No reliable significant risk factor was found influencing the LEMG progression.
- Published
- 2017
- Full Text
- View/download PDF
150. The need of prophylactic central lymph node dissection is controversial in terms of postoperative thyroglobulin follow-up of patients with cN0 papillary thyroid cancer.
- Author
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Korkmaz MH, Öcal B, Saylam G, Çakal E, Bayır Ö, Tutal E, and Tatar EÇ
- Subjects
- Ablation Techniques, Adult, Carcinoma, Papillary blood, Carcinoma, Papillary pathology, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Thyroid Cancer, Papillary, Thyroid Neoplasms blood, Thyroid Neoplasms pathology, Treatment Outcome, Carcinoma, Papillary surgery, Lymph Node Excision, Neck Dissection, Thyroglobulin blood, Thyroid Neoplasms surgery, Thyroidectomy
- Abstract
Purpose: The objective of this study was to investigate whether prophylactic central lymph node dissection (pCLND) facilitates postoperative thyroglobulin (Tg) follow-up in the patients with papillary thyroid carcinoma (PTC). We also questioned whether radioactive iodine (RAI) remnant ablation provides any further advantage in this regard., Methods: The records of patients with low-intermediate risk PTC who underwent either only total thyroidectomy (TT) or TT in conjunction with pCLND were reviewed. Adjuvant RAI ablation was performed depending on tumor diameter, multifocality, the presence of positive lymph nodes and adverse histopathologic features. Pre-ablative and post-ablative Tg levels, post-operative complications and clinico-pathological characteristics were compared between the two groups (TT alone and TT with pCLND)., Results: Among the 302 patients, TT was performed in 140 (46.4%) and TT with pCLND in 162 (53.6%). More than half of all patients in both groups had papillary microcarcinoma (58.0% and 53,1%, respectively). Postoperatively, the median preablative Tg level was higher in the TT only group than that of the TT with pCLND group (0.96 vs 0.27 ng/ml, respectively). The post-ablative Tg levels were undetectable in both groups at the last follow-up visit. Also, a subgroup of patients (19.5%) who did not receive RAI ablation all became athyroglobulinemic at one year after surgery., Conclusions: Although performing pCLND with TT seems to have an advantage over TT alone as to achieve lower Tg levels in the early post-operative period, Tg levels become comparable following RAI ablation. On the other hand, the patients who have not been treated with adjuvant RAI ablation, also became athyroglobulinemic regardless of the surgical method.
- Published
- 2017
- Full Text
- View/download PDF
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