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102. Eosinophil Progenitors in Patients With Non-Asthmatic Eosinophilic Bronchitis, Eosinophilic Asthma, and Normal Controls

Author

Zhan, Chen, primary, Xu, Rong, additional, Li, Bizhou, additional, Liu, Jiaxing, additional, Liang, Wanqin, additional, Zhang, Shengfang, additional, Fang, Liman, additional, Zhong, Shuxin, additional, de Silva, S. Dushinka Shaniya Helen, additional, Sivapalan, Dhinesan, additional, Luo, Wei, additional, Li, Jing, additional, Lai, Kefang, additional, Zhong, Nanshan, additional, Sehmi, Roma, additional, O’Byrne, Paul M., additional, and Chen, Ruchong, additional

Published
2022
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104. Clinical and Inflammatory Characteristics of the Chinese APAC Cough Variant Asthma Cohort

Author

Lai, Kefang, primary, Zhan, Wenzhi, additional, Wu, Feng, additional, Zhang, Yunhui, additional, Lin, Lin, additional, Li, Wen, additional, Yi, Fang, additional, Jiang, Ziyu, additional, Dai, Yuanrong, additional, Li, Suyun, additional, Lin, Jiangtao, additional, Yuan, Yadong, additional, Jiang, Yong, additional, Qiu, Chen, additional, Zhao, Limin, additional, Chen, Meihua, additional, Qiu, Zhongmin, additional, Li, Hu, additional, Chen, Ruchong, additional, Luo, Wei, additional, Xie, Jiaxing, additional, Guo, Chunxing, additional, Jiang, Mei, additional, Yang, Xiaohong, additional, Shi, Guochao, additional, Sun, Dejun, additional, Chen, Rongchang, additional, Chung, Kian Fan, additional, Shen, Huahao, additional, and Zhong, Nanshan, additional

Published
2022
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107. Short-acting beta-2 agonist prescription patterns and clinical outcomes in Chinese patients with asthma: an observational study in mainland China for the SABINA programme

Author

Bao, Wuping, primary, Zhang, Yingying, additional, Hang, Jingqing, additional, Guo, Yubiao, additional, Tang, Wei, additional, Yun, Chunmei, additional, Deng, Jingmin, additional, Jin, Meiling, additional, Lai, Kefang, additional, Yu, Huapeng, additional, Beekman, Maarten, additional, Zhou, Xin, additional, and Zhang, Min, additional

Published
2022
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113. Group 2 innate lymphoid cells in patients with nonasthmatic eosinophilic bronchitis

Author

Zhan, Chen, primary, Liu, Jiaxing, additional, Li, Bizhou, additional, Xu, Rong, additional, Liang, Wanqin, additional, Zhang, Shengfang, additional, Fang, Liman, additional, Zhong, Shuxin, additional, Shaniya Helen de Silva, S. Dushinka, additional, Sivapalan, Dhinesan, additional, Luo, Wei, additional, Wang, Hongyu, additional, Li, Jing, additional, Lai, Kefang, additional, Zhong, Nanshan, additional, Sehmi, Roma, additional, O’Byrne, Paul M, additional, and Chen, Ruchong, additional

Published
2021
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115. Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology – CHEST Guideline and Expert Panel Report

Author

Lee, Kai K., Davenport, Paul, Smith, Jaclyn A., Irwin, Richard S., McGarvey, Lorcan, Mazzone, Stuart B., Birring, Surinder S., Abu Dabrh, Abd Moain, Altman, Kenneth W., Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Brightling, Christopher, Chang, Anne B., El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Iyer, Vivek, Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., other, and, Lee, Kai K., Davenport, Paul, Smith, Jaclyn A., Irwin, Richard S., McGarvey, Lorcan, Mazzone, Stuart B., Birring, Surinder S., Abu Dabrh, Abd Moain, Altman, Kenneth W., Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Brightling, Christopher, Chang, Anne B., El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Iyer, Vivek, Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and other, and

Abstract

The purpose of this state-of-the-art review is to update the American College of Chest Physicians 2006 guideline on global physiology and pathophysiology of cough. A review of the literature was conducted using PubMed and MEDLINE databases from 1951 to 2019 and using prespecified search terms. We describe the basic phenomenology of cough patterns, behaviors, and morphological features. We update the understanding of mechanical and physiological characteristics of cough, adding a contemporary view of the types of cough and their associated behaviors and sensations. New information about acoustic characteristics is presented, and recent insights into cough triggers and the patient cough hypersensitivity phenotype are explored. Lastly, because the clinical assessment of patients largely focuses on the duration rather than morphological features of cough, we review the morphological features of cough that can be measured in the clinic. This is the first of a two-part update to the American College of Chest Physicians 2006 cough guideline; it provides a more global consideration of cough phenomenology, beyond simply the mechanical aspects of a cough. A greater understanding of the typical features of cough, and their variations, may allow a more informed interpretation of cough measurements and the clinical relevance for patients.

Published
2021

117. The spectrum, clinical features and diagnosis of chronic cough due to rare causes

Author

Lai, Kefang, primary, Tang, Jiaman, additional, Zhan, Wenzhi, additional, Li, Hu, additional, Yi, Fang, additional, Long, Li, additional, Zhou, Jianmeng, additional, Chen, Xiaomei, additional, Huang, Lianrong, additional, Sun, Zhangyu, additional, Jiang, Ziyu, additional, Chen, Yuehan, additional, Lu, Hankun, additional, Luo, Wei, additional, Chen, Ruchong, additional, and Zhong, Nanshan, additional

Published
2021
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121. Global Physiology and Pathophysiology of Cough

Author

Lee, Kai K., primary, Davenport, Paul W., additional, Smith, Jaclyn A., additional, Irwin, Richard S., additional, McGarvey, Lorcan, additional, Mazzone, Stuart B., additional, Birring, Surinder S., additional, Abu Dabrh, AbdMoain, additional, Altman, Kenneth W., additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Brightling, Christopher, additional, Chang, Anne B., additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, AdamT., additional, Iyer, Vivek, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, AndrewP., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, MarkA., additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2021
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125. Life-Threatening and Non-Life-Threatening Complications Associated With Coughing

Author

Irwin, Richard S., primary, Dudiki, Natasha, additional, French, Cynthia L., additional, Abu Dabrh, Abd Moain, additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Canning, Brendan, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Irwin, Richard S., additional, Iyer, Vivek, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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128. Chronic Cough Due to Stable Chronic Bronchitis

Author

Malesker, Mark A., primary, Callahan-Lyon, Priscilla, additional, Madison, J. Mark, additional, Ireland, Belinda, additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Birring, Surinder S., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Chang, Anne B., additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Gibson, Peter, additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lim, Kaiser, additional, Lown, Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molassoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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129. Arnold Nerve Reflex

Author

Mai, Yonglin, primary, Zhan, Chen, additional, Zhang, Shengfang, additional, Liu, Jiaxing, additional, Liang, Wanqin, additional, Cai, Jiawei, additional, Lai, Kefang, additional, Zhong, Nanshan, additional, and Chen, Ruchong, additional

Published
2020
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130. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents

Author

Côté, Andreanne, primary, Russell, Richard J., additional, Boulet, Louis-Philippe, additional, Gibson, Peter G., additional, Lai, Kefang, additional, Irwin, Richard S., additional, Brightling, Christopher E., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Bolser, Donald C., additional, Birring, Surinder S., additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Gibson, Peter, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lown, Mark, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Moore, Abigail, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Vertigan, Anne E., additional, and Weinberger, Miles, additional

Published
2020
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132. Managing Chronic Cough as a Symptom in Children and Management Algorithms

Author

Chang, Anne B., primary, Oppenheimer, John J., additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Blackhall, Fiona, additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Keogh, Karina A., additional, Lai, Kefang, additional, Lane, Andrew P., additional, Lilly, Craig, additional, Lim, Kaiser, additional, Lown, Mark, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Oppenheimer, John, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, and Vertigan, Anne E., additional

Published
2020
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133. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients

Author

Smith, Maeve P., primary, Lown, Mark, additional, Singh, Sonal, additional, Ireland, Belinda, additional, Hill, Adam T., additional, Linder, Jeffrey A., additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Blackhall, Fiona, additional, Birring, Surinder S., additional, Bolser, Donald C., additional, Boulet, Louis-Philippe, additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Harding, Susan M., additional, Harnden, Anthony, additional, Kahrilas, Peter J., additional, Kavanagh, Joanne, additional, Lai, Kefang, additional, Lilly, Craig, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Vertigan, Anne E., additional, and Weinberger, Miles, additional

Published
2020
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134. Short-term outcomes of COVID-19 and risk factors for progression

Author

Long, Li, primary, Zeng, Xiansheng, additional, Zhang, Xu, additional, Xiao, Wei, additional, Guo, E, additional, Zhan, Wenzhi, additional, Yang, Xuejiao, additional, Li, Chunyan, additional, Wu, Caiyun, additional, Xu, Tingting, additional, Zhan, Chen, additional, Chen, Yuehan, additional, Jiang, Mei, additional, Zhong, Nanshan, additional, and Lai, Kefang, additional

Published
2020
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135. Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients.

Author

Jiayang Sun, Chen Zhan, Zheng Deng, Wei Luo, Qiaoli Chen, Mei Jiang, Nanshan Zhong, Kefang Lai, Sun, Jiayang, Zhan, Chen, Deng, Zheng, Luo, Wei, Chen, Qiaoli, Jiang, Mei, Zhong, Nanshan, and Lai, Kefang

Subjects
CHRONIC diseases, INTERFERONS, COUGH, T cells, CAPSAICIN
Abstract

Chronic refractory cough (CRC) is characterised by cough hypersensitivity. Interferon-γ (IFN-γ) has been reported to induce calcium influx, action potentials of vagal neurons in vitro and cough response in guinea pigs. While the effect of IFN-γ in CRC patients remains unknown. Here, via flow-cytometry and inhalation cough challenge, we found CRC patients had significantly increased levels of sputum IFN-γ+CD4+ T cells, IFN-γ+CD8+ T cells as well as supernatant of IFN-γ. The average number of coughs in CRC patients increased as the concentration of inhaled IFN-γ went up in IFN-γ cough challenge. Two or more coughs and five or more coughs elicited by inhaled IFN-γ in CRC patients occurred in 7 of 10 and 2 of 10, respectively. Preinhaled IFN-γ (100 µg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers. Targeting IFN-γ may be a potential effective anti-tussive strategy in CRC patients. [ABSTRACT FROM AUTHOR]

Published
2022
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137. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Author

Smith, Maeve P., Lown, Mark, Singh, Sonal, Ireland, Belinda, Hill, Adam T., Linder, Jeffrey A., Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, other, and, Smith, Maeve P., Lown, Mark, Singh, Sonal, Ireland, Belinda, Hill, Adam T., Linder, Jeffrey A., Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Smith, Jaclyn, Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, and other, and

Abstract

Background: Evidence for the diagnosis and management of cough due to acute bronchitis in immunocompetent adult outpatients was reviewed as an update to the 2006 “Chronic Cough Due to Acute Bronchitis: American College of Chest Physicians (ACCP) Evidence-Based Clinical Practice Guidelines.” Methods: Acute bronchitis was defined as an acute lower respiratory tract infection manifested predominantly by cough with or without sputum production, lasting no more than 3 weeks with no clinical or any recent radiographic evidence to suggest an alternative explanation. Two clinical population, intervention, comparison, outcome questions were addressed by systematic review in July 2017: (1) the role of investigations beyond the clinical assessment of patients presenting with suspected acute bronchitis, and (2) the efficacy and safety of prescribing medication for cough in acute bronchitis. An updated search was undertaken in May 2018. Results: No eligible studies relevant to the first question were identified. For the second question, only one relevant study met eligibility criteria. This study found no difference in number of days with cough between patients treated with an antibiotic or an oral nonsteroidal antiinflammatory agent compared with placebo. Clinical suggestions and research recommendations were made based on the consensus opinion of the CHEST Expert Cough Panel. Conclusions: The panelists suggested that no routine investigations be ordered and no routine medications be prescribed in immunocompetent adult outpatients first presenting with cough due to suspected acute bronchitis, until such investigations and treatments have been shown to be safe and effective at making cough less severe or resolve sooner. If the cough due to suspected acute bronchitis persists or worsens, a reassessment and consideration of targeted investigations should be considered.

Published
2020

138. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Author

Malesker, Mark A., Callahan-Lyon, Priscilla, Madison, J. Mark, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Malesker, Mark A., Callahan-Lyon, Priscilla, Madison, J. Mark, Ireland, Belinda, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., and Vertigan, Anne E.

Abstract

Background: Chronic cough due to chronic bronchitis (CB) causes significant impairment in quality of life, and effective treatment strategies are needed. We conducted a systematic review on the management of chronic cough due to CB to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods: This systematic review asked three questions: (1) What are the clinical features of the history that suggest a patient's cough-phlegm syndrome is due to CB? (2) Can treatment of stable CB improve or eliminate chronic cough? (3) Can therapy that targets chronic cough due to CB prevent or reduce the occurrence of acute CB exacerbations? Studies of adult patients with CB were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the CHEST organization methodology. Results: The search strategy used an assortment of descriptors and assessments to identify studies of chronic cough due to CB. Conclusions: The evidence supporting the management of chronic cough due to CB is limited overall and of low quality. This article provides guidance on treatment by presenting suggestions based on the best currently available evidence and identifies gaps in our knowledge and areas for future research.

Published
2020

139. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Expert Panel Report

Author

Côté, Andreanne, Russell, Richard J., Boulet, Louis Philippe, Gibson, Peter G., Lai, Kefang, Irwin, Richard S., Brightling, Christopher, Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, other, and, Côté, Andreanne, Russell, Richard J., Boulet, Louis Philippe, Gibson, Peter G., Lai, Kefang, Irwin, Richard S., Brightling, Christopher, Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, and other, and

Abstract

Background: Asthma and non-asthmatic eosinophilic bronchitis (NAEB) are among the commonest causes of chronic cough in adults. We sought to determine the role of non-invasive measurements of airway inflammation, including induced sputum and fractional exhaled nitric oxide, in the evaluation of cough associated with asthma, and what the best treatment is for cough due to asthma or NAEB. Methods: We undertook three systematic reviews of randomized controlled trials and observational trials of adults and adolescents > 12 years of age with a chronic cough due to asthma or NAEB. Eligible studies were identified in MEDLINE, CENTRAL, and SCOPUS and assessed for relevance and quality. Guidelines were developed and voted upon using CHEST guideline methodology. Results: Of the citations reviewed, 3/1,175, 53/656, and 6/134 were identified as being eligible for inclusion in the three systematic reviews, respectively. In contrast to established guidelines for asthma therapies in general and the inclusion in some guidelines for a role of biomarkers of airway inflammation to guide treatment in severe disease, the evidence of specific benefit related to the use of non-invasive biomarkers in patients with chronic cough due to asthma was weak. The best therapeutic option for cough in asthma or NAEB is inhaled corticosteroids followed by leukotriene receptor antagonism. Conclusions: This guideline offers recommendations on the role of non-invasive measurements of airway inflammation and treatment for cough due to asthma or NAEB based on the available literature, and identifies gaps in knowledge and areas for future research.

Published
2020

140. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report

Author

Chang, Anne B., Oppenheimer, John, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., other, and, Chang, Anne B., Oppenheimer, John, Irwin, Richard S., Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and other, and

Abstract

Background: Cough is one of the most common presenting symptoms to general practitioners. The objective of this article is to collate the pediatric components of the CHEST chronic cough guidelines that have recently updated the 2006 guidelines to assist general and specialist medical practitioners in the evaluation and management of children who present with chronic cough. Methods: We reviewed all current CHEST Expert Cough Panel's statements and extracted recommendations and suggestions relating to children aged ≤ 14 years with chronic cough (> 4 weeks duration). Additionally, we undertook systematic reviews to update other sections we considered relevant and important. Results: The eight recent CHEST guidelines relevant to children, based on systematic reviews, reported some high-quality evidence in the management of chronic cough in children (eg, use of algorithms and management of wet/productive cough using appropriate antibiotics). However, much evidence is still inadequate, particularly in the management of non-specific cough in the community. Conclusions: The recommendations and suggestions related to the management of chronic cough in the pediatric age group have been based upon high-quality systematic reviews and are summarized in this article. Compared to the 2006 Cough Guidelines, there is now high-quality evidence for some aspects of the management of chronic cough in children. However, further studies particularly in primary health care are required.

Published
2020

141. Group 2 innate lymphoid cells in patients with nonasthmatic eosinophilic bronchitis.

Author

Zhan, Chen, Liu, Jiaxing, Li, Bizhou, Xu, Rong, Liang, Wanqin, Zhang, Shengfang, Fang, Liman, Zhong, Shuxin, Shaniya Helen de Silva, S. Dushinka, Sivapalan, Dhinesan, Luo, Wei, Wang, Hongyu, Li, Jing, Lai, Kefang, Zhong, Nanshan, Sehmi, Roma, O'Byrne, Paul M, and Chen, Ruchong

Subjects
INNATE lymphoid cells, COUGH, PULMONARY eosinophilia, BRONCHITIS, TH2 cells
Abstract

In line with a previous study, we found elevated levels of sputum CD4 SP + sp CRth2 SP + sp T cells compared with HC (Figure 1A; Table S2), suggesting a role for Th2 cells in driving airway eosinophilia in NAEB. Steroid treatment is reported to increase ILC2s cell death, reduce capacity for cell proliferation, and cell trans-differentiation. Brightling CE et al2 reported that NAEB patients had increased proportion of interleukin (IL)-4 SP + sp CD4 SP + sp T cells in bronchoalveolar lavage fluid, suggesting the role of Th2 cells in NAEB. [Extracted from the article]

Published
2022
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142. A new simple score of chronic cough: cough evaluation test

Author

Zhan, Wenzhi, primary, Zhang, Liting, additional, Jiang, Mei, additional, Chen, Meihua, additional, Yuan, Xiaoling, additional, Sun, Jianxin, additional, Xu, Pusheng, additional, Wu, Feng, additional, Zhang, Chunlai, additional, Luo, Wei, additional, Chen, Xiaomei, additional, Li, Hu, additional, and Lai, Kefang, additional

Published
2020
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147. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

Author

Morice, Alyn H., primary, Millqvist, Eva, additional, Bieksiene, Kristina, additional, Birring, Surinder S., additional, Dicpinigaitis, Peter, additional, Domingo Ribas, Christian, additional, Hilton Boon, Michele, additional, Kantar, Ahmad, additional, Lai, Kefang, additional, McGarvey, Lorcan, additional, Rigau, David, additional, Satia, Imran, additional, Smith, Jacky, additional, Song, Woo-Jung, additional, Tonia, Thomy, additional, van den Berg, Jan W.K., additional, van Manen, Mirjam J.G., additional, and Zacharasiewicz, Angela, additional

Published
2019
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149. Chronic Cough and Gastroesophageal Reflux in Children

Author

Chang, Anne B., primary, Oppenheimer, John J., additional, Kahrilas, Peter J., additional, Kantar, Ahmad, additional, Rubin, Bruce K., additional, Weinberger, Miles, additional, Irwin, Richard S., additional, Adams, Todd M., additional, Altman, Kenneth W., additional, Azoulay, Elie, additional, Barker, Alan F., additional, Bolser, Donald C., additional, Birring, Surinder S., additional, Braman, Sidney S., additional, Brightling, Christopher, additional, Callahan-Lyon, Priscilla, additional, Chang, Anne B., additional, Cowley, Terrie, additional, Davenport, Paul, additional, El Solh, Ali A., additional, Escalante, Patricio, additional, Field, Stephen K., additional, Fisher, Dina, additional, French, Cynthia T., additional, Grant, Cameron, additional, Gibson, Peter, additional, Harding, Susan M., additional, Gold, Philip, additional, Harnden, Anthony, additional, Hill, Adam T., additional, Kavanagh, Joanne, additional, Lai, Kefang, additional, Lim, Kaiser, additional, Madison, J. Mark, additional, Malesker, Mark A., additional, Mazzone, Stuart, additional, McGarvey, Lorcan, additional, Metlay, Joshua P., additional, Molasoitis, Alex, additional, Murad, M. Hassan, additional, Narasimhan, Mangala, additional, Newcombe, Peter, additional, Oppenheimer, John, additional, Rosen, Mark, additional, Rubin, Bruce, additional, Russell, Richard J., additional, Ryu, Jay H., additional, Singh, Sonal, additional, Smith, Jaclyn, additional, Smith, Maeve P., additional, Tarlo, Susan M., additional, Turmel, Julie, additional, and Vertigan, Anne E., additional

Published
2019
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