1,685 results on '"Mantica, P"'
Search Results
102. Knowledge gap across continents: the andrology and male infertility exposure among urology residents in the United States and Europe
- Author
-
Ghayda, Ramy Abou, Carrion, Diego M., Gomez Rivas, Juan, Esperto, Francesco, Mantica, Guglielmo, Rodriguez-Socarras, Moises E., Mattigk, Angelika, Kathrins, Martin, O’Leary, Michael, and Niederberger, Craig
- Published
- 2021
- Full Text
- View/download PDF
103. Minkowski's question mark measure is UST--regular
- Author
-
Mantica, Giorgio
- Subjects
Mathematics - Classical Analysis and ODEs ,Mathematics - Dynamical Systems ,Mathematics - Number Theory ,42C05, 31A15, 11B57, 28A80, 37A45 - Abstract
We prove the recent conjecture that Minkowski's question mark measure is regular, in the sense of Ullman-Stahl-Totik., Comment: 14 pages, no figures
- Published
- 2016
104. A note on extended Lorentzian recurrent manifolds
- Author
-
Mantica, Carlo Alberto and Molinari, Luca Guido
- Subjects
Mathematics - Differential Geometry ,53B30 - Abstract
Extended recurrent pseudo-Riemannian manifolds were introduced by Mileva Prvanovic'. We reconsider her work in the light of recent results and show that the manifold is conformally flat, and it is a space of quasi-constant curvature. We also show that an extended recurrent Lorentzian manifold, with time-like associated covector, is a perfect fluid Robertson-Walker space-time. We obtain the equation of state; in n = 4 and if the scalar curvature is zero, a model for incoherent radiation is obtained., Comment: Dedicated to the memory of Dr. Mileva Prvanovic'
- Published
- 2016
105. On the Weyl and Ricci tensors of Generalized Robertson-Walker space-times
- Author
-
Mantica, Carlo Alberto and Molinari, Luca Guido
- Subjects
Mathematical Physics ,General Relativity and Quantum Cosmology ,Mathematics - Differential Geometry ,83C20 (Primary) 53B30 (Secondary) - Abstract
We prove theorems about the Ricci and the Weyl tensors on generalized Robertson-Walker space-times of dimension $n\ge 3$. In particular, we show that the concircular vector introduced by Chen decomposes the Ricci tensor as a perfect fluid term plus a term linear in the contracted Weyl tensor. The Weyl tensor is harmonic if and only if it is annihilated by Chen's vector, and any of the two conditions is necessary and sufficient for the GRW space-time to be a quasi-Einstein (perfect fluid) manifold. Finally, the general structure of the Riemann tensor for Robertson-Walker space-times is given, in terms of Chen's vector. A GRW space-time in n = 4 with null conformal divergence is a Robertson-Walker space-time., Comment: 6 pages
- Published
- 2016
- Full Text
- View/download PDF
106. Minkowski's Question Mark Measure
- Author
-
Mantica, Giorgio
- Subjects
Mathematics - Classical Analysis and ODEs ,Mathematics - Dynamical Systems ,Mathematics - Numerical Analysis ,Mathematics - Number Theory ,42C05, 47B36, 11A55, 11B57, 37D40 - Abstract
Minkowski's question mark function is the distribution function of a singular continuous measure: we study this measure from the point of view of logarithmic potential theory and orthogonal polynomials. We conjecture that it is regular, in the sense of Ullman--Stahl--Totik and moreover it belongs to a Nevai class: we provide numerical evidence of the validity of these conjectures. In addition, we study the zeros of its orthogonal polynomials and the associated Christoffel functions, for which asymptotic formulae are derived. Rigorous results and numerical techniques are based upon Iterated Function Systems composed of Mobius maps., Comment: 31 pages, 17 figures 2-nd revision: added section 7.2, upper and lower bounds to the Hausdorff dimension of the measure
- Published
- 2016
107. From women to women—hematuria during therapy for metastatic breast cancer, what to suspect and when to be alarmed; Bladder metastasis from breast cancer—our experience and a systematic literature review
- Author
-
Rafaela Malinaric, Federica Balzarini, Giorgia Granelli, Arianna Ferrari, Giorgia Trani, Francesca Ambrosini, Guglielmo Mantica, Daniele Panarello, Aldo Franco De Rose, and Carlo Terrone
- Subjects
breast cancer ,urinary bladder ,metastasis ,hematuria ,TURB ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Breast cancer is one of the most important causes of premature mortality in women worldwide. Around 12% of breast cancer patients will develop metastatic disease, a stage associated with poor prognosis, and only 26% of patients are likely to survive for at least 5 years after being diagnosed. Although the most common sites where breast cancer tends to spread are bones, lungs, brain, and liver, it is important that physicians consider other less frequent organs and viscera, like the bladder, as a target destination. In this article we report our experience with this rare form of metastases and a systematic literature review. We analyzed case reports, case series, and review articles present in PubMED/MEDLINE up to March 2022. We excluded the nonrelevant articles, editorials, letters to the editor, and articles written in other languages. We identified a total of 302 articles, with 200 articles being removed before screening; therefore, the total number of abstracts reviewed was 102. Fifty-five articles were excluded before full text review because they did not meet the inclusion criteria, and one article was not retrievable. Therefore, we included a total of 45 articles in this review. The intention of this review is to highlight the importance of the early detection of bladder metastases and to facilitate the diagnostic process for the responsible physician. The most common signs and symptoms and breast cancer subtype associated with bladder metastases, as well as overall survival after their detection, were all assessed. Bladder metastases from metastatic breast cancer are prevalent in the invasive, lobular breast cancer subtype; most patients present with hematuria (39.5%) and the relative 5-year survival rate is 2%. The main limitations of this review are the low number of cases reported in the literature, clinical and pathological differences between the individual cases, and absence of the control group. This study was not funded.
- Published
- 2022
- Full Text
- View/download PDF
108. An original mininvasive corporoplasty technique for penile curvature without circumcision
- Author
-
Antonio Rossi, Giovanni Alei, Pietro Viscuso, Antonio Tufano, Marco Frisenda, Guglielmo Mantica, Pierluigi Bove, Rosario Leonardi, Mauro De Dominicis, and Alessandro Calarco
- Subjects
corporoplasty ,induratio penis plastica ,peyronie's disease ,penis disease ,recurvatum ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: We describe an original minimally invasive penile plication technique with scrotal or infrapubic access, not requiring circumcision, for penile curvature of different severity and types. This technique can be used to correct both congenital and acquired curvatures, mono or bidirectional deformities. Materials and methods: Between 2012 and 2018 we treated 134 patients suffering from congenital curvature (33) and acquired curvature from Peyronie's disease (101). The average curvature was 62.2° (± 30.4°). Preoperative evaluation included prostaglandin E1 injection with photographic documentation and measurement of penile angulation, administration of IIEF- 15, vasoactive penile Doppler ultrasound, analysis of thermal and vibratory sensitivity with Genito-Sensory-Analyzer (GSA) and assessment of nocturnal penile stiffness with Rigiscan, performed twice, for a detailed evaluation of patient’s erectile function. Scrotal access was performed in patients with dorsal and/or lateral penile curvature; the infrapubic access was performed in patients with ventral curvature. After preparation and incision of Colles’ fascia, penis was partially degloved and an original plication technique called "binary corporoplasty" was performed at the site or sites established at preoperative assessment, with non-resorbable synthetic multifilament (Premicron®) suture. Results: Complete correction of penile curvature was achieved in 96.8 % of patients. No major complications were reported, and no patients suffered worsening in erectile function or in penile sensitivity. The average shortening of convex side was 1.65 cm (± 0.7 cm) and all patients report easy intercourse after correction. The average time of surgery was 46 minutes (± 11 min) and all procedures were performed as a day-hospital or ambulatory settings, with local anesthesia and light sedation. Overall satisfaction rate is 96%. Conclusions: This is a simple and rapid technique that perfectly corrects even the most severe and complex penile curvatures. In comparison to traditional techniques, such as Nesbit procedure, this technique is associated with low morbidity, a very low recurrence rate and a great aesthetic results. Aesthetic and functional patients’ satisfaction was excellent.
- Published
- 2022
- Full Text
- View/download PDF
109. Penile lenghthening original technique using a pubo-cavernous spacer. Long term results from a series of over 200 patients
- Author
-
Antonio Rossi, Giovanni Alei, Marco Frisenda, Antonio Tufano, Pietro Viscuso, Guglielmo Mantica, Pierluigi Bove, Rosario Leonardi, and Alessandro Calarco
- Subjects
Penile lenghthening ,penile elongation ,pubo-cavernous spacer ,small penis ,supensory ligament release ,Penile augmentation ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: We report our long experience in the surgical treatment of patients requesting penile lengthening by suspensory ligament release and placement of a custom-made soft silicone pubo-cavernous spacer. The aim was to show that with this surgical technique the results obtained are maintained over time. It is crucial to achieve postoperative satisfaction of these patients who show fragility and self-esteem problems. Methods: From 1999 to 2020, we treated 245 patients with congenital or acquired penile brevity. We carefully analysed the preoperative and postoperative (at 6, 12, 24 and 48 months) penile size of the patients to evaluate whether this technique could allow the long-term maintenance of aesthetic results. We also assessed preoperative erectile function and we focused on the psychological aspects to avoid surgery in patients with dysmorphophobia. This original technique involves the section of the suspensory ligament and the implantation of a silicone spacer between the pubic symphysis and the corpora cavernosa. This spacer is conformed to the patient anatomy and maintains the relationship between the anatomical structures unchanged over time. Sexual self-esteem and patient satisfaction were assessed with the APPSSI questionnaire. Results: The mean increase in penile length was about 2.5 cm in flaccid state and 1.9 cm in stretched state. There were no injuries of the neurovascular bundle or urethra, and no erectile dysfunction was noted. These results persisted at 6, 12, 24 and 48 months without significant differences. Over 80% of patients stated that they were completely satisfied with the results obtained. This satisfaction remained stable along follow up. Conclusion: The section of the suspensory ligament and the implant of the soft silicone spacer provide real penis elongation with satisfactory results that persist over time. This technique avoids the frequent complication of short-term shortening due to the scar adhesions of the edges of the dissected ligament. The high aesthetic satisfaction of patients is stable at controls at 6, 12, 24 and 48 months.
- Published
- 2022
- Full Text
- View/download PDF
110. External validation of Resorlu-Unsal stone score in predicting outcomes after retrograde intrarenal surgery. Experience from a single institution
- Author
-
Antonio Tufano, Marco Frisenda, Antonio Rossi, Pietro Viscuso, Guglielmo Mantica, Pierluigi Bove, Rosario Leonardi, and Alessandro Calarco
- Subjects
Stone ,Kidney ,Endoscopic ,RIRS ,Stone free rate. ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: Pre-operative assessment of renal stones is essential in selecting treatment options and achieving high success rates for retrograde intrarenal surgery (RIRS). Several nephrolithometric scoring systems have been developed using pre-operative clinical data and stone characteristics. Resorlu-Unsal stone score (RUSS) is composed of four different parameters, and each of them adds 1 point to the final score. One point is added in patients with stone size > 20 mm, lower calyceal stones and infundibulo-pelvic angle < 45°, stone number > 1, and abnormal anatomy, respec-tively. RUSS categorizes patients into four distinct groups and aims to predict stone-free rates (SFR) after RIRS. We externally validated RUSS and evaluated its predictive accuracy. Materials and Methods: We performed a retrospective analysis of patients who underwent RIRS for renal stones between January 2020 and December 2021. Patient age, pre-operative hydronephrosis, stone size, stone density as Hounsfield Unit (HU), operative time and RUSS were investigated as potential preoperative predictive factors for stone-free status. RUSS was applied to all patients, and the nomogram was externally vali-dated. Area under the curve (AUC) was used for clinical validity assessment. Results: The present study included a total of 79 patients. Mean patient age was 55.1 ± 15.4 years with a mean stone size was 14.2 ± 4.4 mm. Overall, 62/79 (78.4%) patients were stone free after the initial treatment. After applying RUSS, 36 (45.6%), 29 (36.7%), 10 (12.6%), and 4 (5.1%) patients had a score of 0, 1, 2, and 3, respectively. On multivariate logistic regression RUSS (OR = 0.220; 95%CI: 0.086-0.567; p = 0.002) was identified as the only predictor of postoperative stone-free status. Conclusions: RUSS is a user-friendly scoring system that may predict postoperative stone-free rate after RIRS with great effi-cacy and accuracy.
- Published
- 2022
- Full Text
- View/download PDF
111. Organ harvesting as a mandatory training step of all PGY1 and PGY2 surgical residents
- Author
-
Rafaela Malinaric, Guglielmo Mantica, and Carlo Terrone
- Subjects
Transplant ,Residents ,Urology ,Training ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
To the Editor, Good surgical training is essential for the formation of excellent surgeons, consequently providing the best possible care for our patients in the future. Considering the increase in surgeon shortage over the last two decades (estimated between 14,300 and 23,400 by the year 2032 only in the US), it is important for filling the national health system's needs as well [...].
- Published
- 2022
- Full Text
- View/download PDF
112. How long should we follow patients managed for muscle-invasive bladder cancer? Lesson learned from a recent clinical practice
- Author
-
Aldo Franco De Rose, Francesco Vecco, Francesca Ambrosini, Rafaela Malinaric, Guglielmo Mantica, and Carlo Terrone
- Subjects
MIBC ,follow up ,recurrence ,urethra ,ilealconduit ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
To the Editor, The exact time to stop bladder cancer patient’s follow-up is not well known and there is not a clear recommendation on if and when stop to follow a patient managed for muscle invasive bladder cancer (MIBC). Major urological guidelines do not provide a precise indication on the timing of follow-up, and there is currently no real consensus on optimal time schedule [...].
- Published
- 2022
- Full Text
- View/download PDF
113. Extreme value laws for fractal intensity functions in dynamical systems: Minkowski analysis
- Author
-
Mantica, Giorgio and Perotti, Luca
- Subjects
Mathematics - Dynamical Systems ,Mathematical Physics ,Mathematics - Statistics Theory ,Nonlinear Sciences - Chaotic Dynamics ,Physics - Geophysics ,60G70 (Primary), 37C45, 28A80, 26A30 (Secondary) - Abstract
Typically, in the dynamical theory of extremal events, the function that gauges the intensity of a phenomenon is assumed to be convex and maximal, or singular, at a single, or at most a finite collection of points in phase--space. In this paper we generalize this situation to fractal landscapes, i.e. intensity functions characterized by an uncountable set of singularities, located on a Cantor set. This reveals the dynamical r\^ole of classical quantities like the Minkowski dimension and content, whose definition we extend to account for singular continuous invariant measures. We also introduce the concept of extremely rare event, quantified by non--standard Minkowski constants and we study its consequences to extreme value statistics. Limit laws are derived from formal calculations and are verified by numerical experiments., Comment: 20 pages, 13 figures
- Published
- 2015
- Full Text
- View/download PDF
114. Conceptual design of a collimated neutron flux monitor and spectrometer for DTT
- Author
-
Cecconello, M., Conroy, S., Ericsson, G., Eriksson, J., Hjalmarsson, A., Sperduti, A., Casiraghi, I., Mantica, P., Vincenzi, P., Bolzonella, T., Agostinetti, P., and Villari, R.
- Published
- 2021
- Full Text
- View/download PDF
115. Quantum Entropies and Decoherence for the Multiparticle Quantum Arnol’d Cat
- Author
-
Giorgio Mantica
- Subjects
classical and quantum entropies ,chaos ,quantum to classical transition ,Science ,Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
I study the scaling behavior in the physical parameters of dynamical entropies, classical and quantum, in a specifically devised model of collision-induced decoherence in a chaotic system. The treatment is fully canonical and no approximations are involved or infinite limits taken. I present this model in a detailed way, in order to clarify my views in the debate about the nature, definition, and relevance of quantum chaos.
- Published
- 2023
- Full Text
- View/download PDF
116. Spinal versus general anesthesia during retrograde intra-renal surgery: A propensity score matching analysis
- Author
-
Alberto Olivero, Lorenzo Ball, Carlotta Fontaneto, Guglielmo Mantica, Paolo Bottino, Paolo Pelosi, and Carlo Terrone
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract. Background:. The indications for retrograde intra-renal surgery (RIRS) have greatly increased, however, there is still no consensus on the use of spinal anesthesia (SA) during this procedure. The aim of this study was to evaluate the comparability of surgical conditions and outcomes with RIRS performed under SA versus general anesthesia (GA) for renal stones. Materials and methods:. This was a prospective, observational study in patients scheduled for RIRS in a single teaching hospital in Italy. Inclusion criteria were age >18 years and the presence of single or multiple renal stones. We recorded information concerning the site of lithiasis, the number of calculi, total stone burden, and the presence of concomitant ureteral stones or hydronephrosis. A propensity score-matched analysis was performed to evaluate the results in terms of surgical outcome, intraoperative and postoperative complications, and analgesia demand balanced for confounding factors. Patients were followed-up until day 90 from discharge. Results:. We included 120 patients, the propensity score-matched cohort included 40 patients in the SA and 40 in the GA groups. The stone-free rate was 67.5% in the GA group and 70.0% in the SA group (p = 0.81). The use of auxiliary procedures within 90 days did not differ between groups (25.0% vs. 22.5%, p = 0.79). No cases of conversion from SA to GA were recorded. We did not find any differences in intraoperative bleedings, perforations, and abortions. Complication rates were similar in the 2 groups (10.0% in GA vs. 5.0% in SA, p = 0.64). Conclusions:. In our cohort, RIRS performed under SA and GA was equivalent in terms of surgical results and complications.
- Published
- 2021
- Full Text
- View/download PDF
117. Nuclear Physics Exascale Requirements Review: An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Nuclear Physics, June 15 - 17, 2016, Gaithersburg, Maryland
- Author
-
Carlson, Joseph, Savage, Martin J, Gerber, Richard, Antypas, Katie, Bard, Deborah, Coffey, Richard, Dart, Eli, Dosanjh, Sudip, Hack, James, Monga, Inder, Papka, Michael E, Riley, Katherine, Rotman, Lauren, Straatsma, Tjerk, Wells, Jack, Avakian, Harut, Ayyad, Yassid, Bass, Steffen A, Bazin, Daniel, Boehnlein, Amber, Bollen, Georg, Broussard, Leah J, Calder, Alan, Couch, Sean, Couture, Aaron, Cromaz, Mario, Detmold, William, Detwiler, Jason, Duan, Huaiyu, Edwards, Robert, Engel, Jonathan, Fryer, Chris, Fuller, George M, Gandolfi, Stefano, Gavalian, Gagik, Georgobiani, Dali, Gupta, Rajan, Gyurjyan, Vardan, Hausmann, Marc, Heyes, Graham, Hix, W Ralph, ito, Mark, Jansen, Gustav, Jones, Richard, Joo, Balint, Kaczmarek, Olaf, Kasen, Dan, Kostin, Mikhail, Kurth, Thorsten, Lauret, Jerome, Lawrence, David, Lin, Huey-Wen, Lin, Meifeng, Mantica, Paul, Maris, Peter, Messer, Bronson, Mittig, Wolfgang, Mosby, Shea, Mukherjee, Swagato, Nam, Hai Ah, navratil, Petr, Nazarewicz, Witek, Ng, Esmond, O'Donnell, Tommy, Orginos, Konstantinos, Pellemoine, Frederique, Petreczky, Peter, Pieper, Steven C, Pinkenburg, Christopher H, Plaster, Brad, Porter, R Jefferson, Portillo, Mauricio, Pratt, Scott, Purschke, Martin L, Qiang, Ji, Quaglioni, Sofia, Richards, David, Roblin, Yves, Schenke, Bjorn, Schiavilla, Rocco, Schlichting, Soren, Schunck, Nicolas, Steinbrecher, Patrick, Strickland, Michael, Syritsyn, Sergey, Terzic, Balsa, Varner, Robert, Vary, James, Wild, Stefan, Winter, Frank, Zegers, Remco, Zhang, He, Ziegler, Veronique, and Zingale, Michael
- Published
- 2017
118. Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle
- Author
-
Johnson, Carys S., Williams, Matthew, Sham, Kendig, Belluschi, Serena, Ma, Wenjuan, Wang, Xiaonan, Lau, Winnie W. Y., Kaufmann, Kerstin B., Krivdova, Gabriela, Calderbank, Emily F., Mende, Nicole, McLeod, Jessica, Mantica, Giovanna, Li, Juan, Grey-Wilson, Charlotte, Drakopoulos, Michael, Basheer, Shaaezmeen, Sinha, Shubhankar, Diamanti, Evangelia, Basford, Christina, Wilson, Nicola K., Howe, Steven J., Dick, John E., Göttgens, Berthold, Green, Anthony R., Francis, Natalie, and Laurenti, Elisa
- Abstract
•Substantial attrition of HSC function occurs within 24 hours of ex vivo culture independently of cell cycle progression.•Inhibition of JAK/STAT signaling during culture adaptation via ruxolitinib improves HSC function ex vivo.
- Published
- 2024
- Full Text
- View/download PDF
119. A process-based approach to understanding and managing triggered seismicity
- Author
-
Hager, Bradford H., Dieterich, James, Frohlich, Cliff, Juanes, Ruben, Mantica, Stefano, Shaw, John H., Bottazzi, Francesca, Caresani, Federica, Castineira, David, Cominelli, Alberto, Meda, Marco, Osculati, Lorenzo, Petroselli, Stefania, and Plesch, Andreas
- Published
- 2021
- Full Text
- View/download PDF
120. Fast-ion orbit origin of neutron emission spectroscopy measurements in the JET DT campaign
- Author
-
Järleblad, H., Stagner, L., Eriksson, J., Nocente, M., Kirov, K., Rud, M., Schmidt, B.S., Maslov, M., King, D., Keeling, D., Maggi, C., Garcia, J., Lerche, E.A., Mantica, P., Dong, Y., Salewski, M., Järleblad, H., Stagner, L., Eriksson, J., Nocente, M., Kirov, K., Rud, M., Schmidt, B.S., Maslov, M., King, D., Keeling, D., Maggi, C., Garcia, J., Lerche, E.A., Mantica, P., Dong, Y., and Salewski, M.
- Abstract
In the JET DTE2 deuterium-tritium campaign, neutron diagnostics were employed to measure 14 MeV neutrons originating from D(T,n)4He reactions. In discharge 99965, a diamond matrix detector (KM14) and a magnetic proton recoil (MPRu) detector with a vertical and an oblique line-of-sight were used, respectively. At the timepoints of interest, a significant decrease in the expected diagnostic signals can be observed as electromagnetic wave heating in the ion cyclotron range of frequencies (ICRF) is switched off. Utilizing only TRANSP simulation data, the fast-ion distribution is found to have been likely composed mostly of trapped orbits. In contrast, analysis performed using orbit weight functions revealed that the majority of neutrons in the KM14 Ed=9.3 MeV and MPRu Xcm=33 cm measurement bins are to have originated from fast deuterium ions on co-passing orbits. This work explains the perhaps surprising results and shows that the relative signal decrease as ICRF heating is switched off is largest for counter-passing orbits. Finally, for the magnetic equilibria of interest, it is shown how stagnation orbits, corresponding to ∼1 % of the fast-ion distribution, were completely unobservable by the KM14 diagnostic.
- Published
- 2024
121. Extraperitoneal cystectomy with ureterocutaneostomy derivation in fragile patients - should it be performed more often?
- Author
-
Rafaela Malinaric, Guglielmo Mantica, Federica Balzarini, Carlo Terrone, and Massimo Maffezzini
- Subjects
Bladder cancer ,Extraperitoneal cystectomy ,Ureterocutaneostomy ,Frailty ,Feasibility. ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction and objectives: Radical cystectomy (RC) continues to be standard of care for muscle-invasive bladder cancer and recurrent or refractory nonmuscle invasive bladder cancer. Unfortunately, it has high rates of perioperative morbidity and mortality. One of the most important predictors of postoperative outcomes is frailty, while the majority of complications are diversion related. The aim of our study was to evaluate safety of extraperitoneal cystectomy with ureterocutaneostomy in patients considered as frail. Materials and methods: We retrospectively collected data of frail patients who underwent extraperitoneal cystectomy with ureterocutaneostomy from October 2018 to August 2020 in a single center. We evaluated frailty by assessing patients' age, body mass index (BMI), nutritional status by Malnutrition Universal Screening Tool, overall health by RAI (Risk Analysis Index) and ASA (American Society of Anaesthesiologists) score, and laboratory analyses. We observed intraoperative outcomes and rates of perioperative (within 30 days) and early postoperative (within 90 days) complications (Clavien-Dindo classification). We defined extraperitoneal cystectomy with ureterocutaneostomy as safe if patients did not develop Clavien Dindo IIIb, or worse, complication. Results: A total of 34 patients, 3 female and 31 male, were analyzed. The median age was 77, BMI 26, RAI 28, ASA 3 and the majority had preexisting renal insufficiency. Blood analyses revealed presence of severe preoperative hypoalbuminemia and anemia in half of our cohort. Intraoperative median blood loss was 250 cc, whilst operative time 245 min. During perioperative period 60% of our cohort developed Clavien Dindo II complication and during early postoperative period 32% of patients required readmission. One death occurred during early postoperative period (2.9%). After 12 months of follow-up, we observed stability of the renal function for most patients. Conclusions: We believe that extraperitoneal cystectomy with ureterocutaneostomy could be considered as a treatment option for elderly and/or frail patients.
- Published
- 2022
- Full Text
- View/download PDF
122. A condition for a perfect-fluid space-time to be a generalized Robertson-Walker space-time
- Author
-
Mantica, Carlo Alberto, Molinari, Luca Guido, and De, Uday Chand
- Subjects
Mathematics - Differential Geometry ,General Relativity and Quantum Cosmology ,Mathematical Physics ,83F20, 53C30, 53C50 - Abstract
A perfect-fluid space-time of dimension n>3 with 1) irrotational velocity vector field, 2) null divergence of the Weyl tensor, is a generalised Robertson-Walker space-time with Einstein fiber. Condition 1) is verified whenever pressure and energy density are related by an equation of state. The contraction of the Weyl tensor with the velocity vector field is zero. Conversely, a generalized Robertson-Walker space-time with null divergence of the Weyl tensor is a perfect-fluid space-time., Comment: 7 pages. Misprint corrected in Sect III
- Published
- 2015
- Full Text
- View/download PDF
123. Ricci solitons on singly warped product manifolds and applications
- Author
-
De, Uday Chand, Mantica, Carlo Alberto, Shenawy, Sameh, and Unal, Bulent
- Subjects
Mathematics - Differential Geometry ,53C25, 53C40 - Abstract
The purpose of this article is to study implications of a Ricci soliton warped product manifold to its base and fiber manifolds. First, it is proved that if a warped product manifold is Ricci soliton then its factors are Ricci soliton. Then we study Ricci soliton on warped product manifolds admitting either a conformal vector field or a concurrent vector field. Finally, we study Ricci soliton on some warped product space-times.
- Published
- 2015
- Full Text
- View/download PDF
124. Attractors of Iterated Function Systems with uncountably many maps
- Author
-
Mantica, Giorgio and Peirone, Roberto
- Subjects
Mathematics - Dynamical Systems ,Mathematical Physics ,Nonlinear Sciences - Chaotic Dynamics ,28A80, 37C20, 37E05 - Abstract
We study the topological properties of attractors of Iterated Function Systems (I.F.S.) on the real line, consisting of affine maps of homogeneous contraction ratio. These maps define what we call a second generation I.F.S.: they are uncountably many and the set of their fixed points is a Cantor set. We prove that when this latter either is the attractor of a finite, non-singular, hyperbolic, I.F.S. (of first generation), or it possesses a particular dissection property, the attractor of the second generation I.F.S. consists of finitely many closed intervals.
- Published
- 2015
125. Numerical computation of the isospectral torus of finite gap sets and of IFS Cantor sets
- Author
-
Mantica, Giorgio
- Subjects
Mathematics - Spectral Theory ,Mathematical Physics ,Mathematics - Numerical Analysis ,42C05, 31A15, 47B36, 81Q10, 30C30 - Abstract
We describe a numerical procedure to compute the so-called isospectral torus of finite gap sets, that is, the set of Jacobi matrices whose essential spectrum is composed of finitely many intervals. We also study numerically the convergence of specific Jacobi matrices to their isospectral limit. We then extend the analyis to the definition and computation of an "isospectral torus" for Cantor sets in the family of Iterated Function Systems. This analysis is developed with the ultimate goal of attacking numerically the conjecture that the Jacobi matrices of I.F.S. measures supported on Cantor sets are asymptotically almost-periodic., Comment: Contribution to Ed Saff's 70th birthday celebrative volume
- Published
- 2015
126. Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
- Author
-
Guiomar Martín, Yamile Márquez, Federica Mantica, Paula Duque, and Manuel Irimia
- Subjects
Stress responses ,Tissue-specific transcriptomes ,Gene regulation ,Alternative splicing ,Abiotic stress ,Biotic stress ,Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron retention that modulate gene expression. However, a comprehensive study contrasting stress-response and tissue-specific AS patterns and directly comparing them with those of animal models is still missing. Results We generate a massive resource for Arabidopsis thaliana, PastDB, comprising AS and gene expression quantifications across tissues, development and environmental conditions, including abiotic and biotic stresses. Harmonized analysis of these datasets reveals that A. thaliana shows high levels of AS, similar to fruitflies, and that, compared to animals, disproportionately uses AS for stress responses. We identify core sets of genes regulated specifically by either AS or transcription upon stresses or among tissues, a regulatory specialization that is tightly mirrored by the genomic features of these genes. Unexpectedly, non-intron retention events, including exon skipping, are overrepresented across regulated AS sets in A. thaliana, being also largely involved in modulating gene expression through NMD and uORF inclusion. Conclusions Non-intron retention events have likely been functionally underrated in plants. AS constitutes a distinct regulatory layer controlling gene expression upon internal and external stimuli whose target genes and master regulators are hardwired at the genomic level to specifically undergo post-transcriptional regulation. Given the higher relevance of AS in the response to different stresses when compared to animals, this molecular hardwiring is likely required for a proper environmental response in A. thaliana.
- Published
- 2021
- Full Text
- View/download PDF
127. Comparison of Safety, Efficacy and Outcomes of Robot Assisted Laparoscopic Pyeloplasty vs Conventional Laparoscopy
- Author
-
Mantica G, Ambrosini F, Parodi S, Tappero S, and Terrone C
- Subjects
robotic pyeloplasty ,laparoscopic pyeloplasty ,ureteropelvic junction obstruction ,hydronephrosis ,pyeloplasty ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Guglielmo Mantica, Francesca Ambrosini, Stefano Parodi, Stefano Tappero, Carlo Terrone Department of Urology, Policlinico San Martino Hospital, University of Genova, Genova, ItalyCorrespondence: Guglielmo ManticaDepartment of Urology, Policlinico San Martino Hospital, University of Genova, Largo Rosanna Benzi 10, Genova 16132, ItalyTel +39 0105553935Email guglielmo.mantica@gmail.comAbstract: Pyeloplasty is considered the gold standard for the management of ureteropelvic junction obstruction in cases of flank pain, recurrent stone formation or infection, and deteriorating renal function. Over the last two decades, minimally invasive techniques such as robotic (RALP) and laparoscopic pyeloplasty (LP) have become increasingly popular and have been moderately replacing the open approach. This paper aims to provide a comprehensive up-to-date review on safety, efficacy and outcomes regarding robotic repair of UPJO compared to the conventional laparoscopic procedure. RALP represents a viable and innovative alternative to conventional LP with a comparable success and complication rate both in adult and in paediatric fields. The robotic approach seems to add further technical advantages when compared to conventional LP but sustains a higher costs. Currently, the choice to adopt one of the different minimally invasive approaches depends on the surgeon’s preference or experience, and on institutional availability.Keywords: robotic pyeloplasty, laparoscopic pyeloplasty, ureteropelvic junction obstruction, hydronephrosis, pyeloplasty
- Published
- 2020
128. Sexuality during COVID lockdown: a cross-sectional Italian study among hospital workers and their relatives
- Author
-
De Rose, Aldo Franco, Chierigo, Francesco, Ambrosini, Francesca, Mantica, Guglielmo, Borghesi, Marco, Suardi, Nazareno, and Terrone, Carlo
- Published
- 2021
- Full Text
- View/download PDF
129. On conformally recurrent manifolds of dimension greater than 4
- Author
-
Mantica, Carlo A. and Molinari, Luca G.
- Subjects
Mathematics - Differential Geometry ,Mathematical Physics ,53B20, 53C50, 83C20 - Abstract
Conformally recurrent pseudo-Riemannian manifolds of dimension n>4 are investigated. The Weyl tensor is represented as a Kulkarni-Nomizu product. If the square of the Weyl tensor is nonzero, a covariantly constant symmetric tensor is constructed, that is quadratic in the Weyl tensor. Then, by Grycak's theorem, the explicit expression of the traceless part of the Ricci tensor is obtained, up to a scalar function. The Ricci tensor has at most two distinct eigenvalues, and the recurrence vector is an eigenvector. Lorentzian conformally recurrent manifolds are then considered. If the square of the Weyl tensor is nonzero, the manifold is decomposable. A null recurrence vector makes the Weyl tensor of algebraic type IId or higher in the Bel - Debever - Ortaggio classification, while a time-like recurrence vector makes the Weyl tensor purely electric., Comment: Title changed and typos corrected. 14 pages
- Published
- 2014
- Full Text
- View/download PDF
130. Electromagnetic stabilization of tokamak microturbulence in a high-$\beta$ regime
- Author
-
Citrin, J., Garcia, J., Goerler, T., Jenko, F., Mantica, P., Told, D., Bourdelle, C., Hatch, D. R., Hogeweij, G. M. D., Johnson, T., Pueschel, M. J., and Schneider, M.
- Subjects
Physics - Plasma Physics - Abstract
The impact of electromagnetic stabilization and flow shear stabilization on ITG turbulence is investigated. Analysis of a low-$\beta$ JET L-mode discharge illustrates the relation between ITG stabilization, and proximity to the electromagnetic instability threshold. This threshold is reduced by suprathermal pressure gradients, highlighting the effectiveness of fast ions in ITG stabilization. Extensive linear and nonlinear gyrokinetic simulations are then carried out for the high-$\beta$ JET hybrid discharge 75225, at two separate locations at inner and outer radii. It is found that at the inner radius, nonlinear electromagnetic stabilization is dominant, and is critical for achieving simulated heat fluxes in agreement with the experiment. The enhancement of this effect by suprathermal pressure also remains significant. It is also found that flow shear stabilization is not effective at the inner radii. However, at outer radii the situation is reversed. Electromagnetic stabilization is negligible while the flow shear stabilization is significant. These results constitute the high-$\beta$ generalization of comparable observations found at low-$\beta$ at JET. This is encouraging for the extrapolation of electromagnetic ITG stabilization to future devices. An estimation of the impact of this effect on the ITER hybrid scenario leads to a 20% fusion power improvement., Comment: 10 pages, 13 figures. Paper coupled to invited talk at the 41st EPS conference, Berlin, 2014
- Published
- 2014
- Full Text
- View/download PDF
131. Theoretical description of heavy impurity transport and its application to the modelling of tungsten in JET and ASDEX Upgrade
- Author
-
Casson, F. J., Angioni, C., Belli, E. A., Bilato, R., Mantica, P., Odstrcil, T., Puetterich, T., Valisa, M., Garzotti, L., Giroud, C., Hobirk, J., Maggi, C. F., Mlynar, J., Reinke, M. L., contributors, JET EFDA, and team, ASDEX-Upgrade
- Subjects
Physics - Plasma Physics - Abstract
Recent developments in theory-based modelling of core heavy impurity transport are presented, and shown to be necessary for quantitative description of present experiments in JET and ASDEX Upgrade. The treatment of heavy impurities is complicated by their large mass and charge, which result in a strong response to plasma rotation or any small background electrostatic field in the plasma, such as that generated by anisotropic external heating. These forces lead to strong poloidal asymmetries of impurity density, which have recently been added to numerical tools describing both neoclassical and turbulent transport. Modelling predictions of the steady-state two-dimensional tungsten impurity distribution are compared with experimental densities interpreted from soft X-ray diagnostics. The modelling identifies neoclassical transport enhanced by poloidal asymmetries as the dominant mechanism responsible for tungsten accumulation in the central core of the plasma. Depending on the bulk plasma profiles, neoclassical temperature screening can prevent accumulation, and can be enhanced by externally heated species, demonstrated here in ICRH plasmas., Comment: 9 pages, 11 figures, EPS Berlin Plasma Physics 2014, Invited speaker, submitted to Plasma Physics and Controlled Fusion
- Published
- 2014
- Full Text
- View/download PDF
132. Landau-Stark states and cyclotron-Bloch oscillations of a quantum particle
- Author
-
Kolovsky, Andrey R. and Mantica, Giorgio
- Subjects
Quantum Physics ,Condensed Matter - Quantum Gases - Abstract
Recent experimental progress in the creation of synthetic electric and magnetic fields, acting on cold atoms in a two-dimensional lattice, has attracted renewed interest to the problem of a quantum particle in the Hall configuration. The present work contains a detailed analysis of the eigenstates of this system, called Landau-Stark states, and of the associated dynamical phenomenon of cyclotron-Bloch oscillations. It is shown that Landau-Stark states and cyclotron-Bloch oscillations crucially depend on two factors. The first is the orientation of the electric field relative to the primary axes of the lattice. The second is ratio between the frequencies of Bloch and cyclotron oscillations, that is also the ratio between the magnitudes of electric and magnetic fields. The analysis is first carried out in the tight-binding approximation, where the magnetic field is characterized by the Peierls phase entering the hopping matrix elements. Agreement of this analysis with the full quantum theory is also studied., Comment: 39 pages, 26 figures
- Published
- 2014
133. Port-site metastasis and atypical recurrences after robotic-assisted radical cystectomy (RARC): an updated comprehensive and systematic review of current evidences
- Author
-
Mantica, Guglielmo, Smelzo, Salvatore, Ambrosini, Francesca, Tappero, Stefano, Parodi, Stefano, Pacchetti, Andrea, De Marchi, Davide, Gaboardi, Franco, Suardi, Nazareno, and Terrone, Carlo
- Published
- 2020
- Full Text
- View/download PDF
134. Orthogonal polynomials of equilibrium measures supported on Cantor sets
- Author
-
Mantica, Giorgio
- Subjects
Mathematics - Numerical Analysis ,Mathematical Physics ,Mathematics - Complex Variables ,Quantum Physics ,42C05 (Primary) 31A15, 47B36, 81Q10, 30C30 (Secondary) - Abstract
We study the orthogonal polynomials associated with the equilibrium measure, in logarithmic potential theory, living on the attractor of an Iterated Function System. We construct sequences of discrete measures, that converge weakly to the equilibrium measure, and we compute their Jacobi matrices via standard procedures, suitably enhanced for the scope. Numerical estimates of the convergence rate to the limit Jacobi matrix are provided, that show stability and efficiency of the whole procedure. As a secondary result, we also compute Jacobi matrices of equilibrium measures on finite sets of intervals, and of balanced measures of Iterated Function Systems. These algorithms can reach large orders: we study the asymptotic behavior of the orthogonal polynomials and we show that they can be used to efficiently compute Green's functions and conformal mappings of interest in constructive function theory., Comment: 28 pages, 15 figures
- Published
- 2013
- Full Text
- View/download PDF
135. Elasto-viscoplastic modeling of subsidence above gas fields in the Adriatic Sea
- Author
-
F. Gemelli, A. Corradi, G. Volonté, S. Mantica, and M. De Simoni
- Subjects
Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
From the analysis of GPS monitoring data collected above gas fields in the Adriatic Sea, in a few cases subsidence responses have been observed not to directly correlate with the production trend. Such behavior, already described in the literature, may be due to several physical phenomena, ranging from simple delayed aquifer depletion to a much more complex time-dependent mechanical response of subsurface geomaterials to fluid withdrawal. In order to accurately reproduce it and therefore to be able to provide reliable forecasts, in the last years Eni has enriched its 3D finite element geomechanical modeling workflow by adopting an advanced constitutive model (Vermeer and Neher, 1999), which also considers the viscous component of the deformation. While the numerical implementation of such methodology has already been validated at laboratory scale and tested on synthetic hydrocarbon fields, the work herein presents its first application to a real gas field in the Adriatic Sea where the phenomenon has been observed. The results show that the model is capable to reproduce very accurately both GPS data and other available measurements. It is worth remarking that initial runs, characterized by the use of model parameter values directly obtained from the interpretation of mechanical laboratory tests, already provided very good results and only minor tuning operations have been required to perfect the model outcomes. Ongoing R&D projects are focused on a regional scale characterization of the Adriatic Sea basin in the framework of the Vermeer and Neher model approach.
- Published
- 2020
- Full Text
- View/download PDF
136. Blending measurements and numerical models: a novel methodological approach for land subsidence prediction with uncertainty quantification
- Author
-
L. Gazzola, M. Ferronato, M. Frigo, P. Teatini, C. Zoccarato, A. A. I. Corradi, M. C. Dacome, E. Della Rossa, M. De Simoni, and S. Mantica
- Subjects
Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
The use of numerical models for land subsidence prediction above producing hydrocarbon reservoirs has become a common and well-established practice since the early '90s. Usually, uncertainties in the deep rock behavior, which can affect the forecast capability of the models, have been taken into account by running multiple simulations with different constitutive laws and mechanical properties. Then, the most uncertain parameters were calibrated to reproduce available subsidence measurements. The objective of this work is to propose a novel methodological approach for land subsidence prediction and uncertainty quantification by integrating the available monitoring information in numerical models using ad hoc Data Assimilation techniques. The proposed approach allows to: (i) train the model with the available data and improve its accuracy as new information comes in, (ii) quantify the prediction uncertainty by providing confidence intervals and probability measures instead of deterministic outcomes, and (iii) identify the most appropriate rock constitutive model and geomechanical parameters. The methodology is tested in synthetic models of production from hydrocarbon reservoirs. The numerical experiments show that the proposed approach is a promising way to improve the effectiveness and reliability of land subsidence models.
- Published
- 2020
- Full Text
- View/download PDF
137. Numerical simulation of land subsidence above an off-shore Adriatic hydrocarbon reservoir, Italy, by Data Assimilation techniques
- Author
-
M. Frigo, M. Ferronato, L. Gazzola, P. Teatini, C. Zoccarato, M. Antonelli, A. A. I. Corradi, M. C. Dacome, M. De Simoni, and S. Mantica
- Subjects
Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
The numerical prediction of land subsidence above producing reservoirs can be affected by a number of uncertainties, related for instance to the deep rock constitutive behavior, geomechanical properties, boundary and forcing conditions, etc. The quality and the amount of the available observations can help reduce such uncertainties by constraining the numerical model outcome and providing more reliable estimates of the unknown governing parameters. In this work, we address the numerical simulation of land subsidence above a producing hydrocarbon field in the Northern Adriatic, Italy, by integrating the available monitoring data in the computational model with the aid of Data Assimilation strategies. A preliminary model diagnostic analysis, i.e. the χ2-test, allows for identifying the most appropriate forecast ensemble. Then, a Bayesian approach, i.e. the Red Flag technique, and a smoother formulation, i.e. the Ensemble Smoother, provide a significant reduction of the prior uncertainties. The experiment developed on a real-world gas field confirms that the integration of monitoring observations with classical geomechanical models is a valuable approach to improve the reliability of land subsidence predictions and to exploit in a systematic way the increasing amount of available measurement records.
- Published
- 2020
- Full Text
- View/download PDF
138. ρ-Einstein Solitons on Warped Product Manifolds and Applications
- Author
-
Nasser Bin Turki, Sameh Shenawy, H. K. EL-Sayied, N. Syied, and C. A. Mantica
- Subjects
Mathematics ,QA1-939 - Abstract
The purpose of this research is to investigate how a ρ-Einstein soliton structure on a warped product manifold affects its base and fiber factor manifolds. Firstly, the pertinent properties of ρ-Einstein solitons are provided. Secondly, numerous necessary and sufficient conditions of a ρ-Einstein soliton warped product manifold to make its factor ρ-Einstein soliton are examined. On a ρ-Einstein gradient soliton warped product manifold, necessary and sufficient conditions for making its factor ρ-Einstein gradient soliton are presented. ρ-Einstein solitons on warped product manifolds admitting a conformal vector field are also considered. Finally, the structure of ρ-Einstein solitons on some warped product space-times is investigated.
- Published
- 2022
- Full Text
- View/download PDF
139. JET D-T scenario with optimized non-thermal fusion
- Author
-
M. Maslov, E. Lerche, F. Auriemma, E. Belli, C. Bourdelle, C.D. Challis, A. Chomiczewska, A. Dal Molin, J. Eriksson, J. Garcia, J. Hobirk, I. Ivanova-Stanik, Ph. Jacquet, A. Kappatou, Y. Kazakov, D.L. Keeling, D.B. King, V. Kiptily, K. Kirov, D. Kos, R. Lorenzini, E. De La Luna, C.F. Maggi, J. Mailloux, P. Mantica, M. Marin, G. Matthews, I. Monakhov, M. Nocente, G. Pucella, D. Rigamonti, F. Rimini, S. Saarelma, M. Salewski, E.R. Solano, Ž. Štancar, G. Stankunas, H. Sun, M. Tardocchi, D. Van Eester, and JET Contributors
- Subjects
tokamak ,nuclear fusion ,tritium ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
In JET deuterium-tritium (D-T) plasmas, the fusion power is produced through thermonuclear reactions and reactions between thermal ions and fast particles generated by neutral beam injection (NBI) heating or accelerated by electromagnetic wave heating in the ion cyclotron range of frequencies (ICRFs). To complement the experiments with 50/50 D/T mixtures maximizing thermonuclear reactivity, a scenario with dominant non-thermal reactivity has been developed and successfully demonstrated during the second JET deuterium-tritium campaign DTE2, as it was predicted to generate the highest fusion power in JET with a Be/W wall. It was performed in a 15/85 D/T mixture with pure D-NBI heating combined with ICRF heating at the fundamental deuterium resonance. In steady plasma conditions, a record 59 MJ of fusion energy has been achieved in a single pulse, of which 50.5 MJ were produced in a 5 s time window ( P _fus = 10.1 MW) with average Q = 0.33, confirming predictive modelling in preparation of the experiment. The highest fusion power in these experiments, P _fus = 12.5 MW with average Q = 0.38, was achieved over a shorter 2 s time window, with the period of sustainment limited by high-Z impurity accumulation. This scenario provides unique data for the validation of physics-based models used to predict D-T fusion power.
- Published
- 2023
- Full Text
- View/download PDF
140. Isotope mass scaling and transport comparison between JET Deuterium and Tritium L-mode plasmas
- Author
-
T. Tala, A.E. Järvinen, C.F. Maggi, P. Mantica, A. Mariani, A. Salmi, I.S. Carvalho, A. Chomiczewska, E. Delabie, F. Devasagayam, J. Ferreira, W. Gromelski, N. Hawkes, L. Horvath, J. Karhunen, D. King, A. Kirjasuo, E. Kowalska-Strzeciwilk, S. Leerink, M. Lennholm, B. Lomanowski, M. Maslov, S. Menmuir, R.B. Morales, R. Sharma, H. Sun, K. Tanaka, and JET Contributors
- Subjects
isotope mass scaling ,Deuterium and Tritium ,confinement and transport ,JET ,dimensionless scaling ,heat and particle transport ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The dimensionless isotope mass scaling experiment between pure Deuterium and pure Tritium plasmas with matched $\rho^*$ , $\nu^*$ , β _n , q and $T_e/T_i$ has been achieved in JET L-mode with dominant electron heating (NBI+ohmic) conditions. 28% higher scaled energy confinement time $B_t\tau_{E,\mathrm{th}}/A$ is found in favour of the Tritium plasma. This can be cast in the form of the dimensionless energy confinement scaling law as $\Omega_i \tau_{E,\mathrm{th}} \sim A^{0.48 \pm 0.16}$ . This significant isotope mass scaling is consequently seen in the scaled one-fluid heat diffusion coefficient $A \chi_{\mathrm{eff}}/B_t$ which is around 50% lower in the Tritium plasma throughout the whole plasma radius. The isotope mass dependence in the particle transport channel is negligible, supported also by the perturbative particle transport analysis with gas puff modulation. The comparison of the edge particle fuelling or ionisation profiles from the EDGE2D-EIRENE simulations show that the absolute density differences that are necessary for the dimensionless match in the confined plasma dominate over any isotope mass dependencies of particle fuelling and ionization profiles at the plasma edge. Local GENE simulation results indicate a mild anti-gyroBohm effect at $\rho_\mathrm{tor}$ = 0.6 and thereby a small isotope mass dependence in favour of Tritium on heat transport and a negligible effect on particle transport. A significant fraction of the isotope scaling and reduced heat transport observed in the Tritium plasma is not captured in the GENE and ASTRA-TGLF-SAT2 simulations by simply changing the isotope mass for the same input profiles.
- Published
- 2023
- Full Text
- View/download PDF
141. Experiments in high-performance JET plasmas in preparation of second harmonic ICRF heating of tritium in ITER
- Author
-
M.J. Mantsinen, P. Jacquet, E. Lerche, D. Gallart, K. Kirov, P. Mantica, D. Taylor, D. Van Eester, M. Baruzzo, I. Carvalho, C.D. Challis, A. Dal Molin, E. Delabie, E. De La Luna, R. Dumont, P. Dumortier, J. Eriksson, D. Frigione, J. Garcia, L. Garzotti, C. Giroud, R. Henriques, J. Hobirk, A. Kappatou, Y. Kazakov, D. Keeling, D. King, V. Kiptily, M. Lennholm, P. Lomas, C. Lowry, C.F. Maggi, J. Mailloux, M. Maslov, S. Menmuir, I. Monakhov, R.B. Morales, C. Noble, M. Nocente, A. Patel, G. Pucella, C. Reux, D. Rigamonti, F. Rimini, A. Sheikh, S. Silburn, P. Siren, E.R. Solano, Z. Stancar, M. Tardocchi, and JET Contributors
- Subjects
ICRF heating ,fast ions ,computational modelling ,JET tokamak ,H-mode hybrid plasma scenario ,deuterium–tritium fuel mixture ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The reference ion cyclotron resonance frequency (ICRF) heating schemes for ITER deuterium–tritium (D-T) plasmas at the full magnetic field of 5.3 T are second harmonic heating of T and ^3 He minority heating. The wave-particle resonance location for these schemes coincide and are central at a wave frequency of 53 MHz at 5.3 T. Experiments have been carried out in the second major D-T campaign (DTE2) at JET, and in its prior D campaigns, to integrate these ICRF scenarios in JET high-performance plasmas and to compare their performance with the commonly used hydrogen (H) minority heating. In 50:50 D:T plasmas, up to 35% and 5% larger fusion power and diamagnetic energy content, respectively, were obtained with second harmonic heating of T as compared to H minority heating at comparable total input powers and gas injection rates. The core ion temperature was up to 30% and 20% higher with second harmonic T and ^3 He minority heating, respectively, with respect to H minority heating. These are favourable results for the use of these scenarios in ITER and future fusion reactors. According to modelling, adding ICRF heating to neutral beam injection using D and T beams resulted in a 10%–20% increase of on-axis bulk ion heating in the D-T plasmas due to its localisation in the plasma core. Central power deposition was confirmed with the break-in-slope and fast Fourier transform analysis of ion and electron temperature in response to ICRF modulation. The tail temperature of fast ICRF-accelerated tritons, their enhancement of the fusion yield and time behaviour as measured by an upgraded magnetic proton recoil spectrometer and neutral particle analyser were found in agreement with theoretical predictions. No losses of ICRF-accelerated ions were observed by fast ion detectors, which was as expected given the high plasma density of n _e ≈ 7–8 × 10 ^19 m ^−3 in the main heating phase that limited the formation of ICRF-accelerated fast ion tails. ^3 He was introduced in the machine by ^3 He gas injection, and the ^3 He concentration was measured by a high-resolution optical penning gauge in the sub-divertor region. The DTE2 experiments with ^3 He minority heating were carried with a low ^3 He concentration in the range of 2%–4% given the fact that the highest neutron rates with ^3 He minority heating in D plasmas were obtained at low ^3 He concentrations of ∼2%, which also coincided with the highest plasma diamagnetic energy content. In addition to ^3 He introduced by ^3 He gas injection, an intrinsic concentration of ^3 He of the order of 0.2%–0.4% was measured in D-T plasmas before ^3 He was introduced in the device, which is attributed to the radioactive decay of tritium to ^3 He. According to modelling, even such low intrinsic concentrations of ^3 He lead to significant changes in ICRF power partitioning during second harmonic heating of T due to absorption of up to 30% of the wave power by ^3 He.
- Published
- 2023
- Full Text
- View/download PDF
142. Core transport modelling of the DTT full power scenario using different fuelling strategies
- Author
-
B. Baiocchi, L. Aucone, I. Casiraghi, L. Figini, F. Koechl, and P. Mantica
- Subjects
tokamak integrated modelling ,plasma fuelling ,particle transport ,quasi linear transport models ,Electron Cyclotron Resonance Heating ,core transport ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
A theory-based integrated modelling work of plasma response to deuterium fuelling in the new Divertor Tokamak Test facility (DTT) is performed, using the 1.5D transport code JETTO with the quasi-linear anomalous transport model QuaLiKiz for the core region. The full power DTT scenario E1 is investigated. It is characterised by 28.8 MW of Electron Cyclotron Resonance Heating, 10 MW of Neutral Beam Injection and 6 MW of Ion Cyclotron Resonance Heating to the plasma. Plasma density and temperature profile evolution is calculated up to the separatrix using two different fuelling methods, gas puffing and pellet injection, and two different seeding gases, argon and neon. To sustain the desired pedestal density level with gas puffing a big amount of neutral flux at the separatrix is needed. The feasibility limits of the pumping system are exceeded, regardless of the type of impurity introduced, thus making the use of pellets mandatory. The simulations performed with pellet injection as fuelling method predict that the pedestal density is well sustained with realistic parameters foreseen for the DTT pellet injector. Strong dependence of the core density on the electron cyclotron resonance (ECR) power deposition profile is found. Trapped Electron Modes dominance, low outward flux and strongly hollow density in the inner core region are foreseen with central peaked ECR power deposition profile. Ion Temperature Gradient modes dominance, inward flux and robust density sustainment on the whole radial interval are predicted for spread ECR power deposition, though with central density close to the ECR cut-off limit and with peaked impurity densities. An intermediate deposition extension is found to sustain the whole density profile and to obtain flatter core densities, as previously predicted for the reference full power DTT scenario by fixed pedestal simulations. The ECR deposition is negligibly modified by refraction changes both during a single pellet cycle and after several pellet cycles, indicating full compatibility between the ECR system and the pellet injection system.
- Published
- 2023
- Full Text
- View/download PDF
143. How accurate are flux-tube (local) gyrokinetic codes in modeling energetic particle effects on core turbulence?
- Author
-
A. Di Siena, T. Hayward-Schneider, P. Mantica, J. Citrin, F. Vannini, A. Bottino, T. Görler, E. Poli, R. Bilato, O. Sauter, and F. Jenko
- Subjects
fast particles ,turbulence ,gyrokinetics ,nonlinear mode coupling ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Flux-tube (local) gyrokinetic codes are widely used to simulate drift-wave turbulence in magnetic confinement devices. While a large number of studies show that flux-tube codes provide an excellent approximation for turbulent transport in medium-large devices, it still needs to be determined whether they are sufficient for modeling supra-thermal particle effects on core turbulence. This is called into question given the large temperature of energetic particles (EPs), which makes them hardly confined on a single flux-surface, but also due to the radially broad mode structure of EP-driven modes. The primary focus of this manuscript is to assess the range of validity of flux-tube codes in modeling fast ion effects by comparing radially global turbulence simulations with flux-tube results at different radial locations for realistic JET parameters using the gyrokinetic code GENE. To extend our study to a broad range of different plasma scenarios, this comparison is made for four different plasma regimes, which differ only by the profile of the ratio between the plasma kinetic and magnetic pressure. The latter is artificially rescaled to address the (i) electrostatic limit and regimes with (ii) marginally stable, (iii) weakly unstable and (iv) strongly unstable fast ion modes. These EP-driven modes are identified as Alfvénic ion temperature gradient modes (AITG)/kinetic beta-induced Alfvén eigenmodes (KBAE) via linear ORB5 and LIGKA simulations. It is found that the local flux-tube simulations can recover well the global results only in the electrostatic and marginally stable cases. When the AITG/KBAE becomes linearly unstable, the local approximation fails to correctly model the radially broad fast ion mode structure and the consequent global zonal patterns. According to this study, global turbulence simulations are likely required in regimes with linearly unstable AITG/KBAEs. In conditions with different fast ion-driven modes, these results might change.
- Published
- 2023
- Full Text
- View/download PDF
144. Overview of interpretive modelling of fusion performance in JET DTE2 discharges with TRANSP
- Author
-
Ž. Štancar, K.K. Kirov, F. Auriemma, H.-T. Kim, M. Poradziński, R. Sharma, R. Lorenzini, Z. Ghani, M. Gorelenkova, F. Poli, A. Boboc, S. Brezinsek, P. Carvalho, F.J. Casson, C.D. Challis, E. Delabie, D. Van Eester, M. Fitzgerald, J.M. Fontdecaba, D. Gallart, J. Garcia, L. Garzotti, C. Giroud, A. Kappatou, Ye.O. Kazakov, D.B. King, V.G. Kiptily, D. Kos, E. Lerche, E. Litherland-Smith, C.F. Maggi, P. Mantica, M.J. Mantsinen, M. Maslov, S. Menmuir, M. Nocente, H.J.C. Oliver, S.E. Sharapov, P. Sirén, E.R. Solano, H.J. Sun, G. Szepesi, and JET Contributors
- Subjects
deuterium-tritium plasma ,integrated modelling ,fusion performance ,JET ,TRANSP ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
In the paper we present an overview of interpretive modelling of a database of JET-ILW 2021 D-T discharges using the TRANSP code. The main aim is to assess our capability of computationally reproducing the fusion performance of various D-T plasma scenarios using different external heating and D-T mixtures, and to understand the performance driving mechanisms. We find that interpretive simulations confirm a general power-law relationship between increasing external heating power and fusion output, which is supported by absolutely calibrated neutron yield measurements. A comparison of measured and computed D-T neutron rates shows that the calculations’ discrepancy depends on the absolute neutron yield. The calculations are found to agree well with measurements for higher performing discharges with external heating power above ∼20 $\mathrm{MW}$ , while low-neutron shots display an average discrepancy of around +40% compared to measured neutron yields. A similar trend is found for the ratio between thermal and beam-target fusion, where larger discrepancies are seen in shots with dominant beam-driven performance. We compare the observations to studies of JET-ILW D discharges, to find that on average the fusion performance is well modelled over a range of heating power, although an increased unsystematic deviation for lower-performing shots is observed. The ratio between thermal and beam-induced D-T fusion is found to be increasing weakly with growing external heating power, with a maximum value of $\gtrsim$ 1 achieved in a baseline scenario experiment. An evaluation of the fusion power computational uncertainty shows a strong dependence on the plasma scenario type and fusion drive characteristics, varying between ±25% and 35%. D-T fusion alpha simulations show that the ratio between volume-integrated electron and ion heating from alphas is $\lesssim$ 10 for the majority of analysed discharges. Alphas are computed to contribute between ∼15% and 40% to the total electron heating in the core of highest performing D-T discharges. An alternative workflow to TRANSP was employed to model JET D-T plasmas with the highest fusion yield and dominant non-thermal fusion component because of the use of fundamental radio-frequency heating of a large minority in the scenario, which is calculated to have provided ∼10% to the total fusion power.
- Published
- 2023
- Full Text
- View/download PDF
145. Impact of interaction between RF waves and fast NBI ions on the fusion performance in JET DTE2 campaign
- Author
-
K.K. Kirov, C.D. Challis, E. De la Luna, J. Eriksson, D. Gallart, J. Garcia, M. Gorelenkova, J. Hobirk, P. Jacquet, A. Kappatou, Y.O. Kazakov, D. Keeling, D. King, E. Lerche, C. Maggi, J. Mailloux, P. Mantica, M. Mantsinen, M. Maslov, S. Menmuir, P. Siren, Z. Stancar, D. Van Eester, and JET Contributors
- Subjects
RF waves ,fast ions ,DT plasma ,JET ,fusion performance ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
This work presents a study of the interaction between radio frequency (RF) waves used for ion cyclotron resonance heating and the fast deuterium (D) and tritium (T) neutral Beam injected (NBI) ions in DT plasma. The focus is on the effects of this interaction, also referred to as synergistic effects, on the fusion performance in the recent JET DTE2 campaign. Experimental data from dedicated pulses at 3.43 T/2.3 MA heated at (i) 51.4 MHz, giving the central minority H and n = 2 D, and at (ii) 32.2 MHz for the central minority ^3 He and n = 2 T. Resonances are analysed and conclusions are drawn and supported by modelling of the synergistic effects. Modelling with transport code TRANSP runs with and without the RF kick operator predict a moderate increase, of about 10%, in DT rates for the case of the RF wave—fast D NBI ion interactions at the n = 2 harmonic of ion cyclotron resonance, and a negligible impact due to synergistic interaction between fast T NBI ions and RF waves. JETTO modelling gives a 29% enhancement in fusion rates due to the interction between RF waves and fast D NBI ions, and an 18% enhancement in fast T NBI ions. Analysis of experimental neutron rates compared to TRANSP predictions without synergistic effects and magnetic proton recoil neutron spectrometer indicate an enhancement of approximately 25%–28% in fusion rates due to RF interaction with fast D ions, and an enhancement of approximately 5%–8% when RF waves and fast T NBI ions are interacting. The contributions of various heating and fast ion sources are assessed and discussed.
- Published
- 2023
- Full Text
- View/download PDF
146. The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
- Author
-
Chiara Bergaglio, Veronica Giasotto, Michela Marcenaro, Salvina Barra, Marianna Turazzi, Matteo Bauckneht, Alessandro Casaleggio, Francesca Sciabà, Carlo Terrone, Guglielmo Mantica, Marco Borghesi, Alessio Signori, Bruno Spina, Nataniele Piol, Elisa Zanardi, Giuseppe Fornarini, and Jeries Paolo Zawaideh
- Subjects
prostate cancer ,multiparametric MRI ,biochemical recurrence ,Medicine (General) ,R5-920 - Abstract
Background: treated prostate cancer (PCa) patients develop biochemical recurrence (BCR) in 27–53% of cases; the role of MRI in this setting is still controversial. In 2021 a panel of experts proposed a “Prostate Imaging-Recurrence Reporting” (PI-RR) score, aiming to standardize the reporting. The aim of our study is to evaluate the reproducibility of the PI-RR scoring system among readers with different expertise. Methods: in this monocentric, retrospective observational study, the images of patients who underwent MRI with BCR from January 2017 to January 2022 were analyzed by two radiologists and a radiology resident. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were obtained. Interobserver agreement was calculated. The percentage of the PI-RR score of 3 was estimated to find out the proportion of uncertain exams reported among the readers. Results: a total of seventy-six patients were included in our study: eight previously treated with RT and sixty-eight who underwent surgery. The accuracy range was 75–80%, the sensitivity 68.4–71.1%, the specificity 81.6–89.5%, PPV 78.8–87.1%, and NPV 72.1–75.6%. The inter-reader agreement using a binary evaluation (PI-RR ≥ 3 as positive mpMRI) demonstrated a correlation coefficient (k) of 0.74 (95% CI: 0.62–0.87). The percentage for the PI-RR score of 3 was 6.6% for reader one, 14.5% for reader two, and 2.6% for reader three. Conclusion: this study confirmed the good accuracy of mpMRI in the detection of local recurrence of PCa and the good reproducibility of PI-RR score among all readers, confirming it to be a promising tool for the standardization of the assessment of patients with BCR.
- Published
- 2023
- Full Text
- View/download PDF
147. ExOrthist: a tool to infer exon orthologies at any evolutionary distance
- Author
-
Márquez, Yamile, Mantica, Federica, Cozzuto, Luca, Burguera, Demian, Hermoso-Pulido, Antonio, Ponomarenko, Julia, Roy, Scott W., and Irimia, Manuel
- Published
- 2021
- Full Text
- View/download PDF
148. Evaluating the differences in the early laparoscopic donor nephrectomy learning curves of a Swiss high volume transplant program and a South African low volume transplant program after knowledge transfer
- Author
-
van der Merwe, André, Ebinger Mundorf, N. Nicole, van Heerden, H., Bonkat, G., van Deventer, H., Mantica, G., Keyser, Z., and Bachmann, A.
- Published
- 2021
- Full Text
- View/download PDF
149. Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
- Author
-
Martín, Guiomar, Márquez, Yamile, Mantica, Federica, Duque, Paula, and Irimia, Manuel
- Published
- 2021
- Full Text
- View/download PDF
150. PRIMER REPORTE DE Spodoptera eridania (Stoll) (Lepidoptera: Noctuidae) EN EL CENTRO DE LA PROVINCIA DE SANTA FE
- Author
-
A. LUTZ, I. BERTOLACCINI, R. R. SCOTTA, F. MANTICA, M. F. MAGLIANO, P. D. SANCHEZ, and M. C. CURIS
- Subjects
glycine max ,daños ,oruga militar del sur ,argentina ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Este trabajo reporta por primera vez la presencia de Spodoptera eridania (Stoll) en el centro de la Provincia de Santa Fe. Larvas del género Spodoptera fueron recolectadas en un lote de soja Bt y trasladadas a la cámara de cría (FCA-UNL), donde se obtuvo la primera generación. Mediante claves taxonómicas se corroboró que la especie recolectada era S. eridania, plaga de origen tropical presente en el noroeste de Argentina, de hábito polífago que ocasiona daños al alimentarse de hojas y frutos en formación en varios cultivos de importancia económica. Además esta especie es tolerante a la proteína Bt y resistente a insecticidas de uso convencional. Al alimentar las larvas con hojas de soja Bt, completaron su ciclo biológico de manera exitosa. No existe información acerca del comportamiento de esta especie en el centro de la provincia de Santa Fe.
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.