Biomaterials, natural or synthetic materials that have been adapted for clinical use, have been a historically important tool in the development of care regimen for many years. In order to be considered successful, the material must be strong, fit to purpose and biocompatible. Calcium sulphate (CS), a naturally occurring compound, has often been used clinically as a bone cement or void filling biomaterial, precisely due to its biocompatibility, rigidity, and capacity to be fully resorbed. A significant danger to the success of biomaterials as biological implants is that of microbial invasion and adhesion to the surface material which drives infection of the surrounding area, and this can require many lengthy and costly procedures to correct. To address this issue, the resorptive properties of calcium sulphate have often been studied to examine their potential for release of antibacterial compounds to help combat local infection. However, there has been little said for those infections driven by fungal organisms. It was hypothesised that antifungal-loaded CS beads would be successful in eluting antifungal agents, consistently, over a period of 7-days, and would significantly inhibit both planktonic and sessile fungal cells of clinically relevant organisms. Firstly, it was the aim to determine what, if any, concentration of drug was eluted from CS beads and if it was sufficient to provide a minimum inhibitory concentration against clinically relevant fungi. Next, it was an aim to investigate how the CS beads might inhibit pre-grown and developing biofilms. Finally, it was an aim to investigate what, if any, effect beads may have on fungal cells incubated alongside host tissue. To close the loop and explore future directions in the field, the literature relating to wound biofilms was interrogated to provide a quantitative analysis of terms relating to the topic, as well as highlight the relevance of this study to the field. A panel of 16 fungal species were selected an