411 results on '"Nohr, Ellen Aagaard"'
Search Results
102. Perfluoroalkyl acids and time to pregnancy revisited: An update from the Danish National Birth Cohort
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Bach, Cathrine Carlsen, primary, Liew, Zeyan, additional, Bech, Bodil Hammer, additional, Nohr, Ellen Aagaard, additional, Fei, Chunyuan, additional, Bonefeld-Jorgensen, Eva Cecilie, additional, Henriksen, Tine Brink, additional, and Olsen, Jørn, additional
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- 2015
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103. Optimization of heart failure medication after cardiac resynchronization therapy and the impact on long-term survival
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Witt, Christoffer Tobias, primary, Kronborg, Mads Brix, additional, Nohr, Ellen Aagaard, additional, Mortensen, Peter Thomas, additional, Gerdes, Christian, additional, and Nielsen, Jens Cosedis, additional
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- 2015
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104. No Association of Maternal Gestational Weight Gain with Offspring Blood Pressure and Hypertension at Age 18 Years in Male Sibling-Pairs: A Prospective Register-Based Cohort Study
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Scheers Andersson, Elina, primary, Tynelius, Per, additional, Nohr, Ellen Aagaard, additional, Sørensen, Thorkild I. A., additional, and Rasmussen, Finn, additional
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- 2015
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105. Use of Inhaled and Oral Corticosteroids in Pregnancy and the Risk of Malformations or Miscarriage
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Bjørn, Anne-Mette Bay, primary, Ehrenstein, Vera, additional, Nohr, Ellen Aagaard, additional, and Nørgaard, Mette, additional
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- 2015
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106. Maternal Bereavement and Cryptorchidism in Offspring
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Ingstrup, Katja Glejsted, primary, Olsen, Jørn, additional, Wu, Chun Sen, additional, Nohr, Ellen Aagaard, additional, Bech, Bodil Hammer, additional, Li, Jiong, additional, Susser, Ezra, additional, and Jensen, Morten Søndergaard, additional
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- 2015
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- View/download PDF
107. Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review
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Bach, Cathrine Carlsen, primary, Bech, Bodil Hammer, additional, Brix, Nis, additional, Nohr, Ellen Aagaard, additional, Bonde, Jens Peter Ellekilde, additional, and Henriksen, Tine Brink, additional
- Published
- 2014
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108. Use of Corticosteroids in Early Pregnancy is Not Associated With Risk of Oral Clefts and Other Congenital Malformations in Offspring
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Bay Bjørn, Anne-Mette, primary, Ehrenstein, Vera, additional, Hundborg, Heidi Holmager, additional, Nohr, Ellen Aagaard, additional, Sørensen, Henrik Toft, additional, and Nørgaard, Mette, additional
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- 2014
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109. Common variants at 6q22 and 17q21 are associated with intracranial volume
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Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stephanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Jr., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Jr., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Grant, Struan F. A., St Pourcain, Beate, Timpson, Nicholas J., Smith, George Davey, Sovio, Ulla, Nalls, Mike A., Au, Rhoda, Hofman, Albert, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Jaddoe, Vincent W. V., Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Jr., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Adair, Linda S., Ang, Wei, Atalay, Mustafa, vanBeijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Hottenga, Jouke Jan, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpelainen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimaki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcarcel, Beatriz, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sorensen, Thorkild I. A., Wilson, James F., Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stephanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Jr., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Jr., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Grant, Struan F. A., St Pourcain, Beate, Timpson, Nicholas J., Smith, George Davey, Sovio, Ulla, Nalls, Mike A., Au, Rhoda, Hofman, Albert, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Jaddoe, Vincent W. V., Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Jr., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Adair, Linda S., Ang, Wei, Atalay, Mustafa, vanBeijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Hottenga, Jouke Jan, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpelainen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimaki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcarcel, Beatriz, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sorensen, Thorkild I. A., and Wilson, James F.
- Abstract
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size., Erratum published in Nature Genetics 2012 Vol 44 no 6 p732.
- Published
- 2012
- Full Text
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110. Common variants at 12q15 and 12q24 are associated with infant head circumference
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Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Moller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Monica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bonnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J., McMahon, George, Mentch, Frank D., Mueller-Nurasyid, Martina, O'Reilly, Paul F., Prokopenko, Inga, Rivadeneira, Fernando, Steegers, Eric A. P., Sunyer, Jordi, Tiesler, Carla, Yaghootkar, Hanieh, Breteler, Monique M. B., Debette, Stephanie, Fornage, Myriam, Gudnason, Vilmundur, Launer, Lenore J., van der Lugt, Aad, Mosley, Thomas H., Jr., Seshadri, Sudha, Smith, Albert V., Vernooij, Meike W., Blakemore, Alexandra I. F., Chiavacci, Rosetta M., Feenstra, Bjarke, Fernandez-Banet, Julio, Grant, Struan F. A., Hartikainen, Anna-Liisa, van der Heijden, Albert J., Iniguez, Carmen, Lathrop, Mark, McArdle, Wendy L., Molgaard, Anne, Newnham, John P., Palmer, Lyle J., Palotie, Aarno, Pouta, Annneli, Ring, Susan M., Sovio, Ulla, Standl, Marie, Uitterlinden, Andre G., Wichmann, H-Erich, Vissing, Nadja Hawwa, DeCarli, Charles, van Duijn, Cornelia M., McCarthy, Mark I., Koppelman, Gerard H., Estivill, Xavier, Hattersley, Andrew T., Melbye, Mads, Bisgaard, Hans, Pennell, Craig E., Widen, Elisabeth, Hakonarson, Hakon, Smith, George Davey, Heinrich, Joachim, Jarvelin, Marjo-Riitta, Jaddoe, Vincent W. V., Adair, Linda S., Ang, Wei, Atalay, Mustafa, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Hottenga, Jouke Jan, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpelainen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimaki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcarcel, Beatriz, White, Scott, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sorensen, Thorkild I. A., Wilson, James F., Schmidt, Reinhold, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Coker, Laura H., Longstreth, W. T., Jr., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Jr., Nalls, Mike A., Au, Rhoda, Gudnason, Haukur, Harris, Tamara B., Meeks, William M., van Buchem, Mark A., Catellier, Diane, Windham, B. Gwen, Wolf, Philip A., Schmidt, Helena, Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Moller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Monica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bonnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J., McMahon, George, Mentch, Frank D., Mueller-Nurasyid, Martina, O'Reilly, Paul F., Prokopenko, Inga, Rivadeneira, Fernando, Steegers, Eric A. P., Sunyer, Jordi, Tiesler, Carla, Yaghootkar, Hanieh, Breteler, Monique M. B., Debette, Stephanie, Fornage, Myriam, Gudnason, Vilmundur, Launer, Lenore J., van der Lugt, Aad, Mosley, Thomas H., Jr., Seshadri, Sudha, Smith, Albert V., Vernooij, Meike W., Blakemore, Alexandra I. F., Chiavacci, Rosetta M., Feenstra, Bjarke, Fernandez-Banet, Julio, Grant, Struan F. A., Hartikainen, Anna-Liisa, van der Heijden, Albert J., Iniguez, Carmen, Lathrop, Mark, McArdle, Wendy L., Molgaard, Anne, Newnham, John P., Palmer, Lyle J., Palotie, Aarno, Pouta, Annneli, Ring, Susan M., Sovio, Ulla, Standl, Marie, Uitterlinden, Andre G., Wichmann, H-Erich, Vissing, Nadja Hawwa, DeCarli, Charles, van Duijn, Cornelia M., McCarthy, Mark I., Koppelman, Gerard H., Estivill, Xavier, Hattersley, Andrew T., Melbye, Mads, Bisgaard, Hans, Pennell, Craig E., Widen, Elisabeth, Hakonarson, Hakon, Smith, George Davey, Heinrich, Joachim, Jarvelin, Marjo-Riitta, Jaddoe, Vincent W. V., Adair, Linda S., Ang, Wei, Atalay, Mustafa, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Hottenga, Jouke Jan, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpelainen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimaki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcarcel, Beatriz, White, Scott, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sorensen, Thorkild I. A., Wilson, James F., Schmidt, Reinhold, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Coker, Laura H., Longstreth, W. T., Jr., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Jr., Nalls, Mike A., Au, Rhoda, Gudnason, Haukur, Harris, Tamara B., Meeks, William M., van Buchem, Mark A., Catellier, Diane, Windham, B. Gwen, Wolf, Philip A., and Schmidt, Helena
- Abstract
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
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- 2012
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111. Maternal Recreational Exercise during Pregnancy in relation to Children's BMI at 7 Years of Age
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Schou Andersen, Camilla, Juhl, Mette, Gamborg, Michael, Sørensen, Thorkild I A, Nohr, Ellen Aagaard, Schou Andersen, Camilla, Juhl, Mette, Gamborg, Michael, Sørensen, Thorkild I A, and Nohr, Ellen Aagaard
- Abstract
Exposures during fetal life may have long-term health consequences including risk of childhood overweight. We investigated the associations between maternal recreational exercise during early and late pregnancy and the children's body mass index (BMI) and risk of overweight at 7 years. Data on 40,280 mother-child pairs from the Danish National Birth Cohort was used. Self-reported information about exercise was obtained from telephone interviews around gestational weeks 16 and 30. Children's weight and height were reported in a 7-year follow-up and used to calculate BMI and overweight status. Data was analyzed using multiple linear and logistic regression models. Recreational exercise across pregnancy was inversely related to children's BMI and risk of overweight, but all associations were mainly explained by smoking habits, socioeconomic status, and maternal pre-pregnancy BMI. Additionally, we did not find exercise intensity or changes in exercise habits in pregnancy related to the children's BMI or risk of overweight.
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- 2012
112. Genome-wide population-based association study of extremely overweight young adults--the GOYA study
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Paternoster, Lavinia, Evans, David M, Nohr, Ellen Aagaard, Holst, Claus, Gaborieau, Valerie, Brennan, Paul, Gjesing, Anette Prior, Grarup, Niels, Witte, Daniel R, Jørgensen, Torben, Linneberg, Allan René, Lauritzen, Torsten, Sandbaek, Anelli, Hansen, Torben, Pedersen, Oluf Borbye, Elliott, Katherine S, Kemp, John P, St Pourcain, Beate, McMahon, George, Zelenika, Diana, Hager, Jörg, Lathrop, Mark, Timpson, Nicholas J, Smith, George Davey, Sørensen, Thorkild I A, Paternoster, Lavinia, Evans, David M, Nohr, Ellen Aagaard, Holst, Claus, Gaborieau, Valerie, Brennan, Paul, Gjesing, Anette Prior, Grarup, Niels, Witte, Daniel R, Jørgensen, Torben, Linneberg, Allan René, Lauritzen, Torsten, Sandbaek, Anelli, Hansen, Torben, Pedersen, Oluf Borbye, Elliott, Katherine S, Kemp, John P, St Pourcain, Beate, McMahon, George, Zelenika, Diana, Hager, Jörg, Lathrop, Mark, Timpson, Nicholas J, Smith, George Davey, and Sørensen, Thorkild I A
- Abstract
Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.
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- 2011
113. Weight gain in different periods of pregnancy and offspring's body mass index at 7 years of age
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Andersen, Camilla Schou, Gamborg, Michael, Sørensen, Thorkild I A, Nohr, Ellen Aagaard, Andersen, Camilla Schou, Gamborg, Michael, Sørensen, Thorkild I A, and Nohr, Ellen Aagaard
- Abstract
We investigated how average weekly gestational weight gain rates during three periods of pregnancy were related to the offspring's body mass index (BMI) at 7 years of age.
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- 2011
114. Use of prescribed drugs among primiparous women: an 11-year population-based study in Denmark
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Bjørn,Anne-Mette Bay, Nørgaard,Mette, Hundborg,Heidi Holmager, Nohr,Ellen Aagaard, Ehrenstein,Vera, Bjørn,Anne-Mette Bay, Nørgaard,Mette, Hundborg,Heidi Holmager, Nohr,Ellen Aagaard, and Ehrenstein,Vera
- Abstract
Anne-Mette Bay Bjørn1, Mette Nørgaard1, Heidi Holmager Hundborg1, Ellen Aagaard Nohr2, Vera Ehrenstein11Department of Clinical Epidemiology, Aarhus University Hospital, 2Department of Epidemiology, Institute of Public Health, University of Aarhus, DenmarkPurpose: To describe patterns of prescribed drug use over time among primiparous women in Denmark.Methods: Through the Danish Medical Birth Registry, we identified all primiparous women giving live birth or stillbirth at ≥ 22 gestational weeks in northern Denmark, from 1999 to 2009. From the Aarhus University Prescription Database we obtained information on the women's prescriptions for reimbursed drugs filled from 30 days before conception until delivery.Results: Among 85,710 primiparous women, 47,982 (56.0%) redeemed at least one prescription from 30 days before conception until delivery. Women aged 35 years and older had the highest overall prevalence of prescription drug use (61.1%). Age-standardized prevalence of drug use was 54.7% in 1999 and 61.2% in 2009, prevalence ratio (PR) of 1.13 (95% confidence interval 1.10; 1.16), adjusted for age and smoking.Conclusion: Over the 11-year period from 1999 to 2009, we found a modest increase in overall use of drugs by primiparous women in Denmark. This increase was not, however, explained by an increasing proportion of older first-time mothers. We noted changes in patterns of use of anti-infective drugs and antidepressants.Keywords: drug utilization, epidemiology, pregnancy
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- 2011
115. Socio-occupational status and congenital anomalies
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Varela, María M Morales-Suárez, Nohr, Ellen Aagaard, Llopis-González, Agustin, Andersen, Ann-Marie Nybo, Olsen, Jorn, Varela, María M Morales-Suárez, Nohr, Ellen Aagaard, Llopis-González, Agustin, Andersen, Ann-Marie Nybo, and Olsen, Jorn
- Abstract
The aim of this study is to investigate the association between socio-occupational status and the frequency of major congenital anomalies in offspring.
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- 2009
116. Foot pronation is not associated with increased injury risk in novice runners wearing a neutral shoe: a 1-year prospective cohort study
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Nielsen, Rasmus Oestergaard, primary, Buist, Ida, additional, Parner, Erik Thorlund, additional, Nohr, Ellen Aagaard, additional, Sørensen, Henrik, additional, Lind, Martin, additional, and Rasmussen, Sten, additional
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- 2013
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117. Predictors of Running-Related Injuries Among 930 Novice Runners
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Nielsen, Rasmus Oestergaard, primary, Buist, Ida, additional, Parner, Erik Thorlund, additional, Nohr, Ellen Aagaard, additional, Sørensen, Henrik, additional, Lind, Martin, additional, and Rasmussen, Sten, additional
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- 2013
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118. Adding the implantable cardioverter-defibrillator to cardiac resynchronization therapy is associated with improved long-term survival in ischaemic, but not in non-ischaemic cardiomyopathy.
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Tobias Witt, Christoffer, Kronborg, Mads Brix, Nohr, Ellen Aagaard, Mortensen, Peter Thomas, Gerdes, Christian, Jensen, Henrik Kjærulf, Nielsen, Jens Cosedis, and Witt, Christoffer Tobias
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CORONARY heart disease complications ,HEART failure treatment ,TREATMENT of cardiomyopathies ,CARDIAC pacemakers ,CARDIAC pacing ,CHI-squared test ,COMPARATIVE studies ,CORONARY disease ,CAUSES of death ,LEFT heart ventricle ,HEART physiology ,ELECTRIC countershock ,HEART failure ,IMPLANTABLE cardioverter-defibrillators ,RESEARCH methodology ,MEDICAL cooperation ,MULTIVARIATE analysis ,CARDIOMYOPATHIES ,RESEARCH ,TIME ,EVALUATION research ,TREATMENT effectiveness ,ACQUISITION of data ,PROPORTIONAL hazards models ,RETROSPECTIVE studies ,STROKE volume (Cardiac output) ,EQUIPMENT & supplies - Abstract
Aims: Cardiac resynchronization therapy (CRT) improves symptoms, left ventricular function, and survival in patients with heart failure (HF) and wide QRS. The benefit of adding implantable cardioverter-defibrillator (ICD) backup is debated. We analysed the long-term outcome of patients with HF due to ischaemic cardiomyopathy (ICM) or non-ischaemic cardiomyopathy (NICM) treated with a CRT device with or without defibrillator backup.Methods and Results: In this observational study, consecutive patients with an ejection fraction ≤35% and QRS width ≥120 ms receiving a CRT device at Aarhus University Hospital, Denmark from 2000 to 2010 were included. Baseline characteristics were retrieved from patient files and survival data were obtained from the Danish Civil Registration System. The primary outcome was all-cause mortality. The effect of ICD backup was estimated using Cox proportional hazards model, and the multivariate analyses were adjusted for a priori selected variables. We included 917 HF patients, 427 with NICM, and 490 with ICM. Median follow-up was 4.0 years. Adjusted hazard ratio (aHR) for all-cause mortality was 0.76 [95% confidence interval (95% CI), 0.60-0.97; P = 0.03] in all patients; 0.96 (95% CI, 0.60-1.51; P = 0.85) in patients with NICM, and 0.74 (95% CI, 0.56-0.97; P = 0.03) in patients with ICM. In patients with NICM, ICD backup seemed to be associated with improved survival among non-responders to CRT (P = 0.08), but not among responders (P = 0.61).Conclusion: Adding an ICD backup is associated with better survival in CRT recipients. This effect was evident among patients with ICM, but not in patients with NICM. [ABSTRACT FROM AUTHOR]- Published
- 2016
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119. Maternal Recreational Exercise during Pregnancy in relation to Children’s BMI at 7 Years of Age
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Schou Andersen, Camilla, primary, Juhl, Mette, additional, Gamborg, Michael, additional, Sørensen, Thorkild I. A., additional, and Nohr, Ellen Aagaard, additional
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- 2012
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120. Estimating Bias From Loss to Follow-up in the Danish National Birth Cohort
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Greene, Naomi, primary, Greenland, Sander, additional, Olsen, Jørn, additional, and Nohr, Ellen Aagaard, additional
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- 2011
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121. Risk factors for lead complications in cardiac pacing: A population-based cohort study of 28,860 Danish patients
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Kirkfeldt, Rikke Esberg, primary, Johansen, Jens Brock, additional, Nohr, Ellen Aagaard, additional, Moller, Mogens, additional, Arnsbo, Per, additional, and Nielsen, Jens Cosedis, additional
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- 2011
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122. Obesity and age at menarche
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Shrestha, Anshu, primary, Olsen, Jørn, additional, Ramlau-Hansen, Cecilia Høst, additional, Bech, Bodil Hammer, additional, and Nohr, Ellen Aagaard, additional
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- 2011
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123. Weight gain in different periods of pregnancy and offspring's body mass index at 7 years of age
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Andersen, Camilla Schou, primary, Gamborg, Michael, additional, Sørensen, Thorkild I. A., additional, and Nohr, Ellen Aagaard, additional
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- 2011
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124. The effect on the birth experience of women and partners of giving birth in a "birth environment room": A secondary analysis of a randomised controlled trial.
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Hansen, Merete Lausten, Lorentzen, Iben Prentow, Andersen, Charlotte S., Jensen, Henriette Svenstrup, Fogsgaard, Ann, Foureur, Maralyn, Jepsen, Ingrid, and Nohr, Ellen Aagaard
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To evaluate women and partners' experience of birth in a "birth environment room" compared to a standard birth room. A single centre parallel randomised controlled trial. Women and partners were enrolled during a 3-year period (May 2015 to March 2018). The Department of Obstetrics and Gynaecology at Herning Hospital, Denmark. A total of 680 Danish speaking nulliparous women, more than 18 years old, with a singleton pregnancy in cephalic presentation, and a spontaneous onset of labour, and their partners were randomly assigned to give birth in a "birth environment room" (n = 340) or in a standard birth room (n = 340) on arrival at the birth unit. Outcomes were the overall birth experience and overall satisfaction with care, measured on a Likert scale, obtained in the postpartum questionnaire sent to the women 6 weeks after birth and to their partners 1/2 weeks after birth. Other outcomes were "staff support for partner", "undisturbed contact with new-born", "feeling of being listened to", "level of information", "attention to psychological needs", "suggestions for pain-relief", "participation in decision-making", "midwife present when wanted", "support from midwife", "birth wishes were met", "loss of internal control" (only women), "loss of external control", "support from partner" (partners: "being supportive for partner"), "importance of physical environment for birth" and "importance of physical environment for staff´s ability to involve the women" (only women). All outcomes were prespecified. We applied Mann Whitney U test for comparing the two groups. Data were collected from 326 women and 236 partners in the intervention group and from 315 women and 209 partners in the control group. The intention-to-treat analysis revealed no difference in the overall experience of birth for women or partners (p 0.81 and p 0.17, respectively). Partners in the intervention group reported more overall satisfaction with care compared to partners in the control group (p 0.048). In the intervention group, fewer women and partners responded they had not had the opportunity for undisturbed contact with their new-born in the first hours after birth (RR 0.19 (95% CI 0.04-0.87) and OR 0.00 CI (0.00–0.83), respectively). Otherwise, there were no differences between groups. The thematic analysis revealed that many women and partners felt they were not able to benefit from the features in "the birth environment room" in the most intense hours of birth. "The birth environment room" did not improve the overall experience of birth for women and partners. Partners in the intervention group were overall more satisfied with care. These findings are of importance in the developing of physical birth environments that support the mental/emotional process of labour. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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125. Chronic Hypertension Related to Risk for Preterm and Term Small for Gestational Age Births
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Catov, Janet M., primary, Nohr, Ellen Aagaard, additional, Olsen, Jorn, additional, and Ness, Roberta B., additional
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- 2008
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126. Research: Children's Health. Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort.
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Liew, Zeyan, Ritz, Beate, von Ehrenstein, Ondine S., Bech, Bodil Hammer, Nohr, Ellen Aagaard, Fei, Chunyuan, Bossi, Rossana, Henriksen, Tine Brink, Bonefeld-Jørgensen, Eva Cecilie, and Olsen, Jørn
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RISK factors of attention-deficit hyperactivity disorder ,AUTISM risk factors ,ATTENTION-deficit hyperactivity disorder ,AUTISM ,CONFIDENCE intervals ,FLUOROCARBONS ,RESEARCH funding ,RELATIVE medical risk ,CASE-control method ,DATA analysis software ,STATISTICAL models ,DESCRIPTIVE statistics ,ODDS ratio ,CHILDREN ,FETUS ,PREGNANCY - Abstract
Background: Perfluoroalkyl substances (PFASs) are persistent pollutants found to be endocrine disruptive and neurotoxic in animals. Positive correlations between PFASs and neurobehavioral problems in children were reported in cross-sectional data, but findings from prospective studies are limited. Objectives: We investigated whether prenatal exposure to PFASs is associated with attention deficit/hyperactivity disorder (ADHD) or childhood autism in children. Methods: Among 83,389 mother-child pairs enrolled in the Danish National Birth Cohort during 1996-2002, we identified 890 ADHD cases and 301 childhood autism cases from the Danish National Hospital Registry and the Danish Psychiatric Central Registry. From this cohort, we randomly selected 220 cases each of ADHD and autism, and we also randomly selected 550 controls frequency matched by child's sex. Sixteen PFASs were measured in maternal plasma collected in early or mid-pregnancy. We calculated risk ratios (RRs) using generalized linear models, taking into account sampling weights. Results: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in all samples; four other PFASs were quantified in ≥ 90% of the samples. We did not find consistent evidence of associations between mother's PFAS plasma levels and ADHD [per natural log nanograms per milliliter increase: PFOS RR = 0.87 (95% CI: 0.74, 1.02); PFOA RR = 0.98 (95% CI: 0.82, 1.16)] or autism [per natural log nanograms per milliliter increase: PFOS RR = 0.92 (95% CI: 0.69, 1.22); PFOA RR = 0.98 (95% CI: 0.73, 1.31)]. We found positive as well as negative associations between higher PFAS quartiles and ADHD in models that simultaneously adjusted for all PFASs, but these estimates were imprecise. Conclusions: In this study we found no consistent evidence to suggest that prenatal PFAS exposure increases the risk of ADHD or childhood autism in children. Citation: Liew Z, Ritz B, von Ehrenstein OS, Bech BH, Nohr EA, Fei CY, Bossi R, Henriksen TB, Bonefeld-Jørgensen EC, Olsen J. 2015. Attention deficit/hyperactivity disorder and childhood autism in association with prenatal exposure to perfluoroalkyl substances: a nested case–control study in the Danish National Birth Cohort. Environ Health Perspect 123:367-373; http://dx.doi.org/10.1289/ehp.1408412 [ABSTRACT FROM AUTHOR]
- Published
- 2015
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127. Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review.
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Bach, Cathrine Carlsen, Bech, Bodil Hammer, Brix, Nis, Nohr, Ellen Aagaard, Bonde, Jens Peter Ellekilde, and Henriksen, Tine Brink
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PERFLUORO compounds ,FETAL development ,EPIDEMIOLOGY ,BIRTH weight ,GESTATIONAL age ,PUBLIC health - Abstract
Background: Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. However, the results of human studies are inconsistent. Objectives: To summarize the evidence of an association between exposure to PFASs, particularly PFOS and PFOA, and human fetal growth. Methods: Systematic literature searches were performed in MEDLINE and EMBASE. We included original studies on pregnant women with measurements of PFOA or PFOS in maternal blood during pregnancy or the umbilical cord and associations with birth weight or related outcomes according to the PFAS level. Citations and references from the included articles were investigated to locate more relevant articles. Study characteristics and results were extracted to structured tables. The completeness of reporting as well as the risk of bias and confounding were assessed. Results: Fourteen studies were eligible. In utero PFOA exposure was associated with decreased measures of continuous birth weight in all studies, even though the magnitude of the association differed and many results were statistically insignificant. PFOS exposure and birth weight were associated in some studies, while others found no association. Conclusions: Higher PFOS and PFOA concentrations were associated with decreased average birth weight in most studies, but only some results were statistically significant. The impact on public health is unclear, but the global exposure to PFASs warrants further investigation. [ABSTRACT FROM AUTHOR]
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- 2015
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128. Does Low Participation in Cohort Studies Induce Bias?
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Nohr, Ellen Aagaard, primary, Frydenberg, Morten, additional, Henriksen, Tine Brink, additional, and Olsen, Jorn, additional
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- 2006
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129. Prepregnancy Obesity and Fetal Death: A Study Within the Danish National Birth Cohort
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Nohr, Ellen Aagaard, primary, Bech, Bodil Hammer, additional, Davies, Michael John, additional, Frydenberg, Morten, additional, Henriksen, Tine Brink, additional, and Olsen, Jorn, additional
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- 2006
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130. Prepregnancy Obesity and Fetal Death
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Nohr, Ellen Aagaard, primary, Bech, Bodil Hammer, additional, Davies, Michael John, additional, Frydenberg, Morten, additional, Henriksen, Tine Brink, additional, and Olsen, Jorn, additional
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- 2005
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131. Maternal Recreational Exercise during Pregnancy in relation to Children's BMI at 7 Years of Age.
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Andersen, Camilla Schou, Juhl, Mette, Gamborg, Michael, Sørensen, Thorkild I. A., and Nohr, Ellen Aagaard
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MATERNAL health ,EXERCISE ,PREGNANCY ,BODY mass index ,INFANT health ,SOCIAL status - Abstract
Exposures during fetal life may have long-term health consequences including risk of childhood overweight. We investigated the associations between maternal recreational exercise during early and late pregnancy and the children's body mass index (BMI) and risk of overweight at 7 years. Data on 40,280 mother-child pairs from the Danish National Birth Cohort was used. Self-reported information about exercise was obtained from telephone interviews around gestational weeks 16 and 30. Children's weight and height were reported in a 7-year follow-up and used to calculate BMI and overweight status. Data was analyzed using multiple linear and logistic regression models. Recreational exercise across pregnancy was inversely related to children's BMI and risk of overweight, but all associations were mainly explained by smoking habits, socioeconomic status, and maternal pre-pregnancy BMI. Additionally, we did not find exercise intensity or changes in exercise habits in pregnancy related to the children's BMI or risk of overweight. [ABSTRACT FROM AUTHOR]
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- 2012
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132. Screening of substance use in pregnancy: A Danish cross‐sectional study.
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Rausgaard, Nete Lundager Klokker, Ibsen, Inge Olga, Fruekilde, Palle Bach Nielsen, Nohr, Ellen Aagaard, Damkier, Per, and Ravn, Pernille
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SUBSTANCE abuse in pregnancy , *LIQUID chromatography-mass spectrometry , *PREGNANT women , *SUBSTANCE abuse , *CROSS-sectional method - Abstract
Introduction: There is a paucity of objectively verified data on substance use among Danish pregnant women. We estimated the prevalence of substance use including alcohol and nicotine among the general population of Danish pregnant women. Material and Methods: In this anonymous, national, cross‐sectional, descriptive study, pregnant women were invited when attending an ultrasound scan between November 2019 and December 2020 at nine Danish hospitals. Women submitted a urine sample and filled out a questionnaire. Urine samples were screened on‐site with a qualitative urine dipstick for 15 substances including alcohol, nicotine, opioids, amphetamines, cannabis, and benzodiazepines. All screen‐positive urine samples underwent secondary quantitative analyses with gold standard, liquid chromatography‐tandem mass spectrometry (LC–MS/MS) analysis. Results were compared to questionnaire information to analyze the validity of self‐reporting and to examine possible cross‐reactions. Results: A total of 1903 of 2154 invited pregnant women participated (88.3%). The prevalence of dipstick‐positive urine samples was 25.0%. 44.0% of these were confirmed positive, resulting in a total confirmed prevalence of 10.8%. The prevalence of nicotine use was 10.1%—and for all other substances, <0.5%. Nicotine use was more prevalent among younger pregnant women, while other substance use appeared evenly distributed over age groups. Self‐reporting of use of nicotine products was high (71.1%), but low for cannabis and alcohol intake (0% and 33.3%, respectively). Prescription medication explained almost all cases of oxycodone, methylphenidate, and benzodiazepine use. Conclusions: Substance use among pregnant women consisted mainly of nicotine. Dipstick screening involved risks of false negatives and false positives. Except for alcohol intake and cannabis use, dipstick analyses did not seem to provide further information than self‐reporting. LC–MS/MS analyses remain gold standard, and future role of dipstick screenings should be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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133. Mode of birth and long‐term maternal mental health: A follow‐up study in the Danish National Birth Cohort.
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Hjorth, Sarah, Skov, Stina Kruse, Kirkegaard, Helene, Olsen, Jørn, and Nohr, Ellen Aagaard
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SELF-evaluation , *CESAREAN section , *SCALE analysis (Psychology) , *DELIVERY (Obstetrics) , *MENTAL health , *RESEARCH funding , *MOTHERS , *QUESTIONNAIRES , *INTERVIEWING , *POSTNATAL care , *PRENATAL care , *LONGITUDINAL method , *SURVEYS , *PSYCHOLOGICAL stress , *CONFIDENCE intervals , *REGRESSION analysis , *MENTAL depression - Abstract
Background: Cesarean birth has been associated with increased risks of short‐term mental health problems. Little is known about whether these associations persist in the long term. This study aimed to estimate the associations between mode of birth and maternal mental health in midlife while considering mental health before and during pregnancy. Methods: Cohort study among mothers in the Danish National Birth Cohort. Birth mode for each woman's entire reproductive history was obtained from Danish national registries. Symptoms of depression and stress in midlife were self‐reported using validated scales. Log binomial regression was used to calculate risk ratios (RR) with 95% confidence intervals (CI) for the association between birth mode and depressive symptoms. Linear regression was used to calculate mean difference in stress score by birth mode. Results: Among 42,872 women, 15.5% reported depressive symptoms at follow‐up, where they were, on average, 43.9 years and 11.2 years after their last birth. Compared with women who only ever had spontaneous vaginal births, women who only had cesarean births, or had both cesarean and vaginal births with the last birth by cesarean, reported slightly more symptoms of depression (RR 1.10, 95% CI 1.01;1.20) and stress (mean difference 0.68 on a 100‐point scale, 95% CI 0.10;1.26). Conclusion: Whether due to the birth experience or underlying factors, depression and stress in midlife were more frequent in women with only cesarean births or whose last birth was by cesarean compared with women with vaginal births. [ABSTRACT FROM AUTHOR]
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- 2024
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134. Reproductive history of parous women and urinary incontinence in midlife: A National Birth Cohort follow‐up study.
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Kjeldsen, Anne Cathrine, Taastrøm, Katja Albert, Gommesen, Ditte, Hjorth, Sarah, Axelsen, Susanne, and Nohr, Ellen Aagaard
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Objective Design Setting Population Methods Main outcome measures Results Conclusions To investigate how reproductive history was associated with urinary incontinence in midlife.A follow‐up study.Denmark.A total of 39 977 mothers who participated in the Maternal Follow up (2013–2014) in the Danish National Birth Cohort. National registries provided their reproductive history.How parity, mode of birth and obstetric tears associated with urinary incontinence were estimated with adjusted odds ratios (OR) and 95% CI using logistic regression.Self‐reported urinary incontinence including subtypes stress, urge and mixed urinary incontinence.At an average age of 44 years, the prevalence of any urinary incontinence was 32% (21% stress, 2% urge, and 8% mixed urinary incontinence). Women with two births more often had urinary incontinence than women with one birth (OR 1.20, 95% CI 1.10–1.31). Compared with women with only spontaneous births, a history of only caesarean sections was associated with much lower odds of urinary incontinence (OR 0.39, 95% CI 0.35–0.42) and a history of instrumental births with slightly lower odds (OR 0.92, 95% CI 0.86–0.98). Compared with no tear/first‐degree tear as the largest tear, episiotomy was associated with less urinary incontinence (OR 0.91, 95% CI 0.86–0.97) whereas third/fourth‐degree tears were associated with more (OR 1.14, 95% CI 1.04–1.25). Findings were mainly explained by similar associations with stress and mixed urinary incontinence.Vaginal birth was associated with a higher risk of long‐term urinary incontinence, but our results indicate that this risk may be reduced by shortening the second stage of birth. [ABSTRACT FROM AUTHOR]
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- 2024
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135. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
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Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C., Küpers, Leanne K., Kho, Alvin T., Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O., Kazmi, Nabila, Salas, Lucas A., Rezwan, Faisal I., Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L., Melton, Phillip E., Lawlor, Debbie A., Pershagen, Göran, Breton, Carrie V., Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S., Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L., Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M., Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A., Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L., Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W., Sørensen, Thorkild I. A., Vrijheid, Martine, Arshad, S. Hasan, Holloway, John W., Håberg, Siri E., Magnus, Per, Dwyer, Terence, Binder, Elisabeth B., DeMeo, Dawn L., Vonk, Judith M., Newnham, John, Tantisira, Kelan G., Kull, Inger, Wiemels, Joseph L., Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C., Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T., Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E., Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F., Koppelman, Gerard H., London, Stephanie J., and Melén, Erik
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3. Good health
136. Common variants at 6q22 and 17q21 are associated with intracranial volume
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Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stéphanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Grant, Struan F. A., Pourcain, Beate St, Timpson, Nicholas J., Smith, George Davey, Sovio, Ulla, Nalls, Mike A., Au, Rhoda, Hofman, Albert, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Jaddoe, Vincent W. V., Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Adair, Linda S., Ang, Wei, Atalay, Mustafa, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Jan Hottenga, Jouke, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpeläinen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimäki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcárcel, Beatriz, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sørensen, Thorkild I. A., Wilson, James F., Ikram, M. Arfan, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stéphanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Taal, H. Rob, Mook-Kanamori, Dennis O., Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Rivadeneira, Fernando, Uitterlinden, Andre G., Knopman, David S., Hartikainen, Anna-Liisa, Pennell, Craig E., Thiering, Elisabeth, Steegers, Eric A. P., Hakonarson, Hakon, Heinrich, Joachim, Palmer, Lyle J., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Grant, Struan F. A., Pourcain, Beate St, Timpson, Nicholas J., Smith, George Davey, Sovio, Ulla, Nalls, Mike A., Au, Rhoda, Hofman, Albert, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Jaddoe, Vincent W. V., Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Adair, Linda S., Ang, Wei, Atalay, Mustafa, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Davis, Oliver S. P., Elliott, Paul, Flexeder, Claudia, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Goh, Liang-Kee, Haworth, Claire M. A., Hadley, Dexter, Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Jan Hottenga, Jouke, Horikoshi, Momoko, Huikari, Ville, Hypponen, Elina, Kilpeläinen, Tuomas O., Kirin, Mirna, Kowgier, Matthew, Lakka, Hanna-Maaria, Lange, Leslie A., Lawlor, Debbie A., Lehtimäki, Terho, Lewin, Alex, Lindgren, Cecilia, Lindi, Virpi, Maggi, Reedik, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Murray, Jeffrey C., Nivard, Michel, Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Rodriguez, Alina, Salem, Rany M., Sebert, Sylvain, Siitonen, Niina, Strachan, David P., Teo, Yik-Ying, Valcárcel, Beatriz, Willemsen, Gonneke, Zeggini, Eleftheria, Boomsma, Dorret I., Cooper, Cyrus, Gillman, Matthew, Hocher, Berthold, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Power, Chris, Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sørensen, Thorkild I. A., and Wilson, James F.
- Abstract
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10−8) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10−11), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10−12), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10−3 for 6q22 and 1.2 × 10−3 for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.
137. Common variants at 12q15 and 12q24 are associated with infant head circumference
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Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J., McMahon, George, Mentch, Frank D., Müller-Nurasyid, Martina, O'Reilly, Paul F., Prokopenko, Inga, Rivadeneira, Fernando, Steegers, Eric A. P., Sunyer, Jordi, Tiesler, Carla, Yaghootkar, Hanieh, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stéphanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Nalls, Mike A., Au, Rhoda, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Mosley, Thomas, Ang, Wei, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Elliott, Paul, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Hadley, Dexter, Hottenga, Jouke Jan, Huikari, Ville, Hypponen, Elina, Kowgier, Matthew, Lawlor, Debbie A., Lewin, Alex, Lindgren, Cecilia, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Nivard, Michel, Palmer, Lyle J., Rodriguez, Alina, Sebert, Sylvain, Standl, Marie, Strachan, David P., Uitterlinden, Andre G., Valcárcel, Beatriz, White, Scott, Willemsen, Gonneke, Boomsma, Dorret I., Grant, Struan F. A., Hakonarson, Hakon, Hattersley, Andrew T., Heinrich, Joachim, Jaddoe, Vincent W. V., McCarthy, Mark I., Pennell, Craig E., Power, Chris, Widen, Elisabeth, Blakemore, Alexandra I. F., Chiavacci, Rosetta M., Feenstra, Bjarke, Fernandez-Banet, Julio, Hartikainen, Anna-Liisa, van der Heijden, Albert J., Iñiguez, Carmen, Lathrop, Mark, McArdle, Wendy L., Mølgaard, Anne, Newnham, John P., Palotie, Aarno, Pouta, Annneli, Ring, Susan M., Sovio, Ulla, Wichmann, H-Erich, Vissing, Nadja Hawwa, Koppelman, Gerard H., Melbye, Mads, Bisgaard, Hans, Smith, George Davey, Adair, Linda S., Atalay, Mustafa, Davis, Oliver S. P., Flexeder, Claudia, Goh, Liang-Kee, Haworth, Claire M. A., Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Horikoshi, Momoko, Kilpeläinen, Tuomas O., Kirin, Mirna, Lakka, Hanna-Maaria, Lange, Leslie A., Lehtimäki, Terho, Lindi, Virpi, Maggi, Reedik, Murray, Jeffrey C., Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Salem, Rany M., Siitonen, Niina, Teo, Yik-Ying, Zeggini, Eleftheria, Cooper, Cyrus, Estivill, Xavier, Gillman, Matthew, Hocher, Berthold, Jarvelin, Marjo-Riitta, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sørensen, Thorkild I. A., Wilson, James F., Taal, H. Rob, St Pourcain, Beate, Thiering, Elisabeth, Das, Shikta, Mook-Kanamori, Dennis O., Warrington, Nicole M., Kaakinen, Marika, Kreiner-Møller, Eskil, Bradfield, Jonathan P., Freathy, Rachel M., Geller, Frank, Guxens, Mònica, Cousminer, Diana L., Kerkhof, Marjan, Timpson, Nicholas J., Ikram, M. Arfan, Beilin, Lawrence J., Bønnelykke, Klaus, Buxton, Jessica L., Charoen, Pimphen, Chawes, Bo Lund Krogsgaard, Eriksson, Johan, Evans, David M., Hofman, Albert, Kemp, John P., Kim, Cecilia E., Klopp, Norman, Lahti, Jari, Lye, Stephen J., McMahon, George, Mentch, Frank D., Müller-Nurasyid, Martina, O'Reilly, Paul F., Prokopenko, Inga, Rivadeneira, Fernando, Steegers, Eric A. P., Sunyer, Jordi, Tiesler, Carla, Yaghootkar, Hanieh, Fornage, Myriam, Smith, Albert V., Seshadri, Sudha, Schmidt, Reinhold, Debette, Stéphanie, Vrooman, Henri A., Sigurdsson, Sigurdur, Ropele, Stefan, Coker, Laura H., Longstreth, W. T., Niessen, Wiro J., DeStefano, Anita L., Beiser, Alexa, Zijdenbos, Alex P., Struchalin, Maksim, Jack, Clifford R., Nalls, Mike A., Au, Rhoda, Gudnason, Haukur, van der Lugt, Aad, Harris, Tamara B., Meeks, William M., Vernooij, Meike W., van Buchem, Mark A., Catellier, Diane, Gudnason, Vilmundur, Windham, B. Gwen, Wolf, Philip A., van Duijn, Cornelia M., Mosley, Thomas H., Schmidt, Helena, Launer, Lenore J., Breteler, Monique M. B., DeCarli, Charles, Mosley, Thomas, Ang, Wei, van Beijsterveldt, Toos, Bergen, Nienke, Benke, Kelly, Berry, Diane, Coin, Lachlan, Elliott, Paul, Frayling, Tim, Gaillard, Romy, Groen-Blokhuis, Maria, Hadley, Dexter, Hottenga, Jouke Jan, Huikari, Ville, Hypponen, Elina, Kowgier, Matthew, Lawlor, Debbie A., Lewin, Alex, Lindgren, Cecilia, Marsh, Julie, Middeldorp, Christel, Millwood, Iona, Nivard, Michel, Palmer, Lyle J., Rodriguez, Alina, Sebert, Sylvain, Standl, Marie, Strachan, David P., Uitterlinden, Andre G., Valcárcel, Beatriz, White, Scott, Willemsen, Gonneke, Boomsma, Dorret I., Grant, Struan F. A., Hakonarson, Hakon, Hattersley, Andrew T., Heinrich, Joachim, Jaddoe, Vincent W. V., McCarthy, Mark I., Pennell, Craig E., Power, Chris, Widen, Elisabeth, Blakemore, Alexandra I. F., Chiavacci, Rosetta M., Feenstra, Bjarke, Fernandez-Banet, Julio, Hartikainen, Anna-Liisa, van der Heijden, Albert J., Iñiguez, Carmen, Lathrop, Mark, McArdle, Wendy L., Mølgaard, Anne, Newnham, John P., Palotie, Aarno, Pouta, Annneli, Ring, Susan M., Sovio, Ulla, Wichmann, H-Erich, Vissing, Nadja Hawwa, Koppelman, Gerard H., Melbye, Mads, Bisgaard, Hans, Smith, George Davey, Adair, Linda S., Atalay, Mustafa, Davis, Oliver S. P., Flexeder, Claudia, Goh, Liang-Kee, Haworth, Claire M. A., Hedebrand, Johannes, Hinney, Anke, Hirschhorn, Joel N., Holloway, John W., Holst, Claus, Horikoshi, Momoko, Kilpeläinen, Tuomas O., Kirin, Mirna, Lakka, Hanna-Maaria, Lange, Leslie A., Lehtimäki, Terho, Lindi, Virpi, Maggi, Reedik, Murray, Jeffrey C., Nohr, Ellen Aagaard, Ntalla, Ioanna, Oken, Emily, Panoutsopoulou, Kalliope, Pararajasingham, Jennifer, Salem, Rany M., Siitonen, Niina, Teo, Yik-Ying, Zeggini, Eleftheria, Cooper, Cyrus, Estivill, Xavier, Gillman, Matthew, Hocher, Berthold, Jarvelin, Marjo-Riitta, Lakka, Timo A., Mohlke, Karen L., Dedoussis, George V., Ong, Ken K., Pearson, Ewan R., Price, Thomas S., Raitakari, Olli T., Saw, Seang-Mei, Scherag, Andre, Simell, Olli, Sørensen, Thorkild I. A., and Wilson, James F.
- Abstract
To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10−9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10−10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height1, their effects on infant head circumference were largely independent of height (P = 3.8 × 10−7 for rs7980687 and P = 1.3 × 10−7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10−6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume2, Parkinson's disease and other neurodegenerative diseases3, 4, 5, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
138. Use of opioids among pregnant women 1997–2016: A Danish drug utilization study.
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Rausgaard, Nete Lundager Klokker, Broe, Anne, Bliddal, Mette, Nohr, Ellen Aagaard, Ibsen, Inge Olga, Albertsen, Trine Lynge, Ravn, Pernille, and Damkier, Per
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PREGNANT women , *DRUG utilization , *PAIN clinics , *OPIOIDS , *OBESITY in women - Abstract
• Overall use of opioids during pregnancy remained stable between 1997 and 2016. • A substantial increase in filled tramadol prescriptions was identified. • Age, social status, smoking, and obesity were associated with opioid use. Use of opioids in pregnancy is of concern yet little is known on opioid prescription patterns in Denmark. The aim of this drug utilization study was to describe prescription patterns for opioids during pregnancy in Denmark from 1997 to 2016. Using the nationwide health care registers, we obtained information on all women with a registered pregnancy in the period 1 January 1997 to 31 December 2016. Opioids were grouped in four: opioids (N02A except codeines), opioid dependency medications (N07BC), cough medications (R05DA except codeines), and codeines (N02AJ06, N02AJ07, N02BA75, and R05DA04). We used logistic regression analyses to identify factors associated with opioid use in pregnancy and cumulative oral morphine equivalent (OMEQ) to estimate volume of use in pregnancy. Prescription patterns were similar for women with live births, non-live births, and terminations. Total use of opioids among women with live born deliveries remained stable at 19.8 per 1000 pregnancies from 1997 to 2016. Codeine use declined from 2008 onwards, while use of other opioids increased from 2007 onwards. This was dominated by a threefold increase in tramadol use (2.0–7.6 per 1000 pregnancies with live births). Codeine was the most used opioid, followed by tramadol and codeine combined with paracetamol. The number of women, who used opioids before pregnancy and continued into their pregnancy, was reduced as the pregnancy progressed. The cumulative oral morphine equivalent during pregnancy was stable until 2007, after which, use prior to pregnancy and during the first two trimesters increased. The odds ratios for opioid use were higher in pregnancies of women of lower socioeconomic status or older age. For live births, odds ratios for opioid use in pregnancy were higher among women with obesity or smoking. Overall use of opioids was stable from 2007 to 2016. This covers a decline in the use of codeine, but a 3-fold increase in tramadol. The number of pregnant women who continued use throughout pregnancy decreased, while OMEQ among persistent users increased. The real-world data suggest an unmet need of specific focus in local Danish Outpatient Clinics and Multidisciplinary Pain Centers both pre-conceptionally and during pregnancy. [ABSTRACT FROM AUTHOR]
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- 2023
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139. How do reproductive history and anthropometry in midlife relate to later risk of pelvic organ prolapse? A prospective cohort study.
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Brülle, Anne-Line, Wu, Chunsen, Rasch, Vibeke, Simonsen, Mette Kildevæld, Schøyen, Ine Schmidt, Dahl, Carina, and Nohr, Ellen Aagaard
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PELVIC organ prolapse , *REPRODUCTIVE history , *MIDDLE age , *OBESITY in women , *LONGITUDINAL method - Abstract
Introduction and hypothesis: The objective was to examine the association between reproductive and anthropometric factors and later risk of pelvic organ prolapse (POP). Methods: We carried out a prospective cohort study including 11,114 female nurses > 44 years from the Danish Nurse Cohort. In 1993, the study population was recruited through the Danish Nurse Organization and self-reported data on age, height, weight, age at menarche, age at first birth and number of childbirths were obtained. POP diagnosis was obtained from the National Patient Registry. Risk of POP was estimated using COX regression and presented as hazard ratios (HR) with 95% confidence intervals (CI). Results: Overall, 10% of the women received a diagnosis of POP within a median follow-up of 22 years. A 4% increase in risk of POP was seen for each increasing BMI (kg/m2) unit at baseline. Compared to women of normal weight, higher risks of POP were seen in overweight (HR 1.18: 1.02–1.36) and obese women (HR 1.33: 1.02–1.74), while underweight had a lower risk (HR 0.51: 0.27–0.95). Compared to women with one childbirth, women with no childbirths had a reduced risk of 57% while increased risks of 46%, 78% and 137% were observed in women with two, three and four childbirths. Women with menarche before the age of 12 tended to have a higher risk of POP as did women who were 30–33 years at their first childbirth. Conclusions: POP is a common health problem in women, and BMI and number of childbirths are strong predictors. [ABSTRACT FROM AUTHOR]
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- 2022
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140. Cardiovascular and metabolic morbidity in women with previous gestational diabetes mellitus: a nationwide register-based cohort study.
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Christensen, Maria Hornstrup, Rubin, Katrine Hass, Petersen, Tanja Gram, Nohr, Ellen Aagaard, Vinter, Christina Anne, Andersen, Marianne Skovsager, and Jensen, Dorte Moeller
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GESTATIONAL diabetes , *DYSLIPIDEMIA , *TRANSIENT ischemic attack , *PERINATAL period , *PREGNANCY outcomes , *MYOCARDIAL ischemia - Abstract
Background: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and has maternal health implications reaching beyond the perinatal period. We aimed to investigate the incidence and severity of cardiovascular and metabolic morbidity in women with previous GDM in a Danish population and to study whether proxies of impaired beta cell function—insulin treatment during GDM pregnancy and development of subsequent manifest diabetes mellitus—influence incident risk of cardiovascular and metabolic morbidity. Methods: A nationwide register-based cohort study was conducted on the complete cohort of 700,648 women delivering in Denmark during 1997–2018. The exposure variable was GDM and primary outcome was overall cardiovascular and metabolic morbidity. Secondary outcomes were major cardiovascular disease (ischemic heart disease, heart failure, and/or stroke/transient cerebral ischemia), hypertension, dyslipidemia, and venous thrombosis. Severity of morbidity was assessed using number of hospital contacts with diagnosis codes related to cardiovascular and metabolic morbidity and number of redemptions of prescribed medication related to cardiovascular and metabolic morbidity in women who developed cardiovascular and metabolic morbidity after pregnancy. Results: The median follow-up period was 10.2–11.9 years with a total range of 0–21.9 years. GDM was associated with increased risk of any cardiovascular and metabolic morbidity (adjusted HR 2.13 [95% CI 2.07–2.20]), major cardiovascular disease (adjusted HR 1.69 [95% CI 1.55–1.84]), hypertension (adjusted HR 1.89 [95% CI 1.82–1.96], dyslipidemia (adjusted HR 4.48 [95% CI 4.28–4.69]), and venous thrombosis (adjusted HR 1.32 [95% CI 1.16–1.50]). Insulin treatment during pregnancy and subsequent development of manifest diabetes exacerbated the risk estimates. Previous GDM was associated with more hospital contacts and more redeemed prescriptions in women developing cardiovascular and metabolic morbidity (p < 0.001). Conclusions: Previous GDM was associated with significantly higher risk of cardiovascular and metabolic morbidity, especially incident dyslipidemia. Risks were exacerbated by proxies of beta cell impairment. Severity of morbidity was significantly worse if GDM preceded cardiovascular and metabolic morbidity. [ABSTRACT FROM AUTHOR]
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- 2022
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141. The FACAM study: protocol for a randomized controlled study of an early interdisciplinary intervention to support women in vulnerable positions through pregnancy and the first 5 years of motherhood.
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Pontoppidan, Maiken, Nygaard, Lene, Thorsager, Mette, Friis-Hansen, Mette, Davis, Deborah, and Nohr, Ellen Aagaard
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Background: Inequality in health can have profound short- and long-term effects on a child's life. Infants develop in a responsive environment, and the relationship between mother and infant begins to develop during pregnancy. The mother's ability to bond with the fetus and newborn child may be challenged by mental health issues which can cause impaired functioning and poorer health outcomes. Families with complex problems need interdisciplinary interventions starting in early pregnancy to be prepared for motherhood and to ensure healthy child development. This study aims to examine the effects of an early and coordinated intervention (the Family Clinic and Municipality (FACAM) intervention) offered to vulnerable pregnant women during pregnancy and the child's first year of life on the mother-child relationship, maternal social functioning, mental health, reflective functioning, well-being, parental stress, and the development and well-being of the child.Methods: The study is a prospective randomized controlled trial where we will randomize 320 pregnant women enrolled to receive antenatal care at the family clinic at Odense University Hospital, to either FACAM intervention or usual care. The FACAM intervention consists of extra support by a health nurse or family therapist during pregnancy and until the child starts school. The intervention is most intensive in the first 12 months and also includes attachment-based support provided either individually or in groups. The participants are assessed at baseline, and when the infant is 3 and 12 months old. The primary outcome is maternal sensitivity measured by the Coding Interactive Behavior (CIB) instrument. Secondary outcomes include prenatal parental reflective functioning, mental well-being, depressive symptoms, breastfeeding duration, maternal satisfaction, child development, parent competence, parental stress, and activities with the child.Discussion: The trial is expected to contribute knowledge about the effect of early coordinated support in antenatal and postnatal care for vulnerable pregnant women and their families.Trial Registration: ClinicalTrials.gov NCT03659721 . Registered on September 6, 2018. [ABSTRACT FROM AUTHOR]- Published
- 2022
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142. Concerns about transmission, changed services and place of birth in the early COVID-19 pandemic: a national survey among Danish pregnant women. The COVIDPregDK study.
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Schrøder, Katja, Stokholm, Lonny, Rubin, Katrine Hass, Jørgensen, Jan Stener, Nohr, Ellen Aagaard, Petersen, Lone Kjeld, and Bliddal, Mette
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COVID-19 pandemic , *INFECTIOUS disease transmission , *MATERNAL health , *HOSPITAL maternity services , *CHILDBIRTH at home - Abstract
Background: The outbreak of the COVID-19 pandemic caused great uncertainty about causes, treatment and mortality of the new virus. Constant updates of recommendations and restrictions from national authorities may have caused great concern for pregnant women. Reports suggested an increased number of pregnant women choosing to give birth at home, some even unassisted ('freebirth') due to concerns of transmission in hospital or reduction in birthplace options. During April and May 2020, we aimed to investigate i) the level of concern about coronavirus transmission in Danish pregnant women, ii) the level of concern related to changes in maternity services due to the pandemic, and iii) implications for choice of place of birth.Methods: We conducted a nationwide cross-sectional online survey study, inviting all registered pregnant women in Denmark (n = 30,009) in April and May 2020.Results: The response rate was 60% (n = 17,995). Concerns of transmission during pregnancy and birth were considerable; 63% worried about getting severely ill whilst pregnant, and 55% worried that virus would be transmitted to their child. Thirtyeight percent worried about contracting the virus at the hospital. The most predominant concern related to changes in maternity services during the pandemic was restrictions on partners' attendance at birth (81%). Especially nulliparous women were concerned about whether cancelled antenatal classes or fewer physical midwifery consultations would affect their ability to give birth or care for their child postpartum.. The proportion of women who considered a home birth was equivalent to pre-pandemic home birth rates in Denmark (3%). During the temporary discontinue of public home birth services, 18% of this group considered a home birth assisted by a private midwife (n = 125), and 6% considered a home birth with no midwifery assistance at all (n = 41).Conclusion: Danish pregnant womens' concerns about virus transmission to the unborn child and worries about contracting the virus during hospital appointments were considerable during the early pandemic. Home birth rates may not be affected by the pandemic, but restrictions in home birth services may impose decisions to freebirth for a small proportion of the population. [ABSTRACT FROM AUTHOR]- Published
- 2021
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143. Incidence and prevalence of keratoconus in Denmark.
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Nielsen, Kim, Hjortdal, Jesper, Nohr, Ellen Aagaard, and Ehlers, Niels
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KERATOCONUS , *CORNEA diseases , *EYE diseases , *PUBLIC health ,DENMARK. National Board of Health - Abstract
Purpose: To estimate the prevalence and incidence of hospitalized keratoconus (KC) in Denmark. Methods: Data extracts from the National Patient Registry under the National Board of Health (which covers the entire Danish population) were analysed. Results: The prevalence of KC was estimated at 86 patients per 100 000 residents and the incidence at 1.3 per 100 000 per year. Conclusion: KC is rather widespread in Denmark, with more than 4600 affected individuals. [ABSTRACT FROM AUTHOR]
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- 2007
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144. Fractures in Childhood and Young Adulthood According to Maternal Smoking in Late Pregnancy. A Danish Cohort Study.
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Rasmussen JB, Rath SM, Wu C, Weile LKK, Schmal H, Olsen J, Bech BH, and Nohr EA
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- Humans, Female, Pregnancy, Denmark epidemiology, Child, Adolescent, Adult, Young Adult, Male, Cohort Studies, Risk Factors, Fractures, Bone epidemiology, Fractures, Bone etiology, Prenatal Exposure Delayed Effects epidemiology, Smoking epidemiology, Smoking adverse effects
- Abstract
Fractures account for the most frequent cause of hospitalization during childhood and numbers have increased over time. Of all fractures in childhood and young adulthood, 66% are recurrent fractures, suggesting that some people are predestined for fractures. The aim of this study was to investigate the association between maternal smoking during late pregnancy and the risk of fractures in the children.The study included 11,082 mothers and their children from the cohort "Healthy Habits for Two" born between 1984 and 1987. Information about maternal smoking during pregnancy came from questionnaires filled out in pregnancy, while information about fractures was derived from the Danish National Patient Registry. Over a follow-up of 24 years (1994-2018), Cox regression with multiple failures was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for fractures in childhood and young adulthood according to maternal smoking in late pregnancy. Information about body mass index (BMI) and smoking status in young adulthood was included as time variant covariates.During an age span of 8-32 years, 6,420 fractures were observed. Of the mothers, 39.1% smoked during late pregnancy. Compared to children of mothers who did not smoke, children of mothers who smoked 1-9 cigarettes per day and 10+ cigarettes per day had an increased risk of fractures (HR 1.14 [CI: 1.06; 1.21] and HR 1.14 [CI: 1.07; 1.22], respectively). After adjusting for BMI and smoking status in young adulthood, the findings were slightly strengthened, showing an increased risk of fractures of 23 and 25% in children of mothers smoking 1-9 cigarettes per day and 10+ cigarettes per day, respectively.Maternal smoking during late pregnancy was associated with a higher risk of fractures in the child. This result indicates that exposure to cigarette smoke in utero may play a role in lifelong bone health., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
- Published
- 2024
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145. Adherence to different forms of plant-based diets and pregnancy outcomes in the Danish National Birth Cohort: A prospective observational study.
- Author
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Hedegaard S, Nohr EA, Olsen SF, Halldorsson TI, and Renault KM
- Subjects
- Humans, Female, Pregnancy, Prospective Studies, Denmark epidemiology, Adult, Infant, Newborn, Birth Weight, Pregnancy Complications epidemiology, Infant, Small for Gestational Age, Cohort Studies, Diet, Plant-Based, Diet, Vegetarian, Pregnancy Outcome epidemiology
- Abstract
Introduction: The number of people adhering to plant-based diets has been increasing dramatically in recent years, fueled by both environmental and animal welfare concerns. Beneficial or possible adverse consequences of such diets, particularly the most restrictive forms during pregnancy, have been minimally explored. The aim of this prospective observational study was to examine associations between different forms of plant-based diets during pregnancy with birth outcomes and pregnancy complications., Material and Methods: The Danish National Birth Cohort included 100 413 pregnancies to 91 381 women in 1996-2002. The population consisted of 66 738 pregnancies, about which sufficient dietary data were available and included in the study. Dietary and supplemental intake was assessed by Food Frequency Questionnaire in gestational week 25 and women were characterized as fish/poultry-vegetarians, lacto/ovo-vegetarians, vegans or omnivorous, based on their self-report in gestational week 30. Main outcome measures were pregnancy and birth complications, birthweight and small for gestational age., Results: A total of 98.7% (n = 65 872) of participants were defined as omnivorous, whereas 1.0% (n = 666), 0.3% (n = 183) and 0.03% (n = 18) identified themselves as fish/poultry vegetarians, lacto/ovo-vegetarians or vegans, respectively. Protein intake was lower among lacto/ovo-vegetarians (13.3%) and vegans (10.4%) than among omnivorous participants (15.4%). Intake of micronutrients was also considerably lower among vegans, but when dietary supplements were taken into consideration, no major differences were observed. Compared with omnivorous mothers, vegans had a higher prevalence of preeclampsia and their offspring had on average -240 g (95% confidence interval -450 to -30) lower birthweight., Conclusions: The women reporting that they adhered to vegan diets during pregnancy had offspring with lower mean birthweight and higher risk of preeclampsia compared with omnivorous mothers. Low protein intake might be one plausible explanation for the observed association with birthweight., (© 2024 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).)
- Published
- 2024
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146. Effects on Child Development and Parent-Child Interaction of the FACAM Intervention: A Randomized Controlled Study of an Interdisciplinary Intervention to Support Women in Vulnerable Positions through Pregnancy and Early Motherhood.
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Pontoppidan M, Nygaard L, Hirani JC, Thorsager M, Friis-Hansen M, Davis D, and Nohr EA
- Subjects
- Humans, Female, Pregnancy, Infant, Adult, Child, Preschool, Mothers psychology, Vulnerable Populations psychology, Child Development, Parent-Child Relations
- Abstract
Health inequality can have a profound impact on a child's life. Maternal mental health challenges can hinder bonding, leading to impaired functioning and poorer child outcomes. To provide extra support for vulnerable pregnant women, the FACAM intervention offers the services of a health nurse or family therapist from pregnancy until the child starts school. This study examined the effects of FACAM intervention on pregnant women in vulnerable positions and their children until the child turned two years old. We randomly assigned 331 pregnant women to either FACAM intervention or care as usual and assessed them at baseline and when the infant was 3-6, 12-13.5, and 24 months old. The primary outcome was maternal sensitivity measured by Coding Interactive Behavior (CIB). Secondary outcomes included the parent-child relationship, child social-emotional development, child developmental progress, parent-child interaction, and child development. Our findings indicate that care-as-usual children were significantly more involved than FACAM children when the child was 4-6 months old (b = -0.25, [-0.42; -0.08] d = -0.42). However, we suspect this result is due to a biased dropout. We did not find any significant differences in any other outcomes. Therefore, the study suggests that the FACAM intervention is not superior to care as usual regarding child development and parent-child interaction outcomes.
- Published
- 2024
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147. Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.
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Crawley C, Sander SD, Nohr EA, Nybo Andersen AM, and Husby S
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- Female, Humans, Adolescent, Cohort Studies, Prospective Studies, Risk Factors, Denmark epidemiology, Celiac Disease epidemiology, Celiac Disease etiology, Celiac Disease diagnosis
- Abstract
Objectives: Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC)., Design: The study was designed as a prospective cohort study, nested in DNBC PARTICIPANTS: The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis., Results: Viral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods., Conclusion: In this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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148. Working life, health and well-being of parents: a joint effort to uncover hidden treasures in European birth cohorts.
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Ubalde-Lopez M, Garani-Papadatos T, Scelo G, Casas M, Lissåker C, Peters S, Nohr EA, Albin M, Lucas R, Papantoniou K, Polańska K, Ramlau-Hansen CH, Šarac J, Selander J, Skröder H, Vasileiou E, Kogevinas M, Bültmann U, Mehlum IS, and Maule M
- Subjects
- Databases, Factual, Europe, Female, Humans, Infant, Newborn, Pregnancy, Birth Cohort, Employment
- Abstract
Objective: Birth cohorts collect valuable and under-utilized information on employment and health of parents before and during pregnancy, at birth, and sometimes after birth. In this discussion paper, we examine how these data could be exploited to study the complex relationships and interactions between parenthood, work, and health among parents themselves., Methods: Using a web-based database of birth cohorts, we summarize information on maternal employment and health conditions and other potentially related variables in cohorts spread throughout Europe. This provided information on what data are available and could be used in future studies, and what was missing if specific questions are to be addressed, exploiting the opportunity to explore work-health associations across heterogenous geographical and social contexts., Results: We highlight the many potentialities provided by birth cohorts and identify gaps that need to be addressed to adopt a life-course approach and investigate topics specific to the peri-pregnancy period, such as psychosocial aspects. We address the technical difficulties implied by data harmonization and the ethical challenges related to the repurposing of data, and provide scientific, ecological and economic arguments in favor of improving the value of data already available as a result of a serious investment in human and material resources., Conclusions: There is a hidden treasure in birth cohorts that deserves to be brought out to study the relationships between employment and health among working parents in a time when the boundaries between work and life are being stretched more than ever before.
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- 2021
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149. Does giving birth in a "birth environment room" versus a standard birth room lower augmentation of labor? - Results from a randomized controlled trial.
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Lorentzen IP, Andersen CS, Jensen HS, Fogsgaard A, Foureur M, Lauszus FF, and Nohr EA
- Abstract
Objective: In the last decade, there has been an increased interest in exploring the impact of the physical birth environment on midwifery practice and women's birth experiences. This study is based on the hypothesis that the environment for birth needs greater attention to improve some of the existing challenges in modern obstetric practice, for example the increasing use of augmentation and number of interventions during delivery., Study Design: A randomized controlled trial was carried out to study the effect of giving birth in a specially designed "birth environment room" on the use of augmentation during labor. The study took place at the Department of Obstetrics and Gynecology, Herning Hospital, Denmark and included 680 nulliparous women in spontaneous labor at term with a fetus in cephalic presentation. Women were randomly allocated to either the "birth environment room" or a standard birth room. The primary outcome was augmentation of labor by use of oxytocin. Secondary outcomes were duration of labor, use of pharmacological pain relief, and mode of birth. Differences were estimated as relative risks (RR) and presented with 95% confidence intervals., Results: No difference was found on the primary outcome, augmentation of labor (29.1% in the "birth environment room" versus 30.6% in the standard room, RR 0.97; 0.89-1.08). More women in the "birth environment room" used the bathtub (60.6% versus 52.4%, RR 1.18; 1.02-1.37), whereas a tendency to lower use of epidural analgesia (22.6% versus 28.2%) did not reach statistical significance (RR 0.87; 0.74-1.02). The chance of an uncomplicated birth was almost similar in the two groups (70.6% in the "birth environment room" versus 72.6% in the standard room, RR 0.97; 0.88-1.07) as were duration of labor (mean 7.9 hours in both groups)., Conclusions: Birthing in a specially designed physical birth environment did not lower use of oxytocin for augmentation of labor. Neither did it have any effect on duration of labor, use of pharmacological pain relief, and chance of birthing without complications. We recommend that future trials are conducted in birth units with greater improvement potentials., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 Published by Elsevier B.V.)
- Published
- 2021
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150. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
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Merid SK, Novoloaca A, Sharp GC, Küpers LK, Kho AT, Roy R, Gao L, Annesi-Maesano I, Jain P, Plusquin M, Kogevinas M, Allard C, Vehmeijer FO, Kazmi N, Salas LA, Rezwan FI, Zhang H, Sebert S, Czamara D, Rifas-Shiman SL, Melton PE, Lawlor DA, Pershagen G, Breton CV, Huen K, Baiz N, Gagliardi L, Nawrot TS, Corpeleijn E, Perron P, Duijts L, Nohr EA, Bustamante M, Ewart SL, Karmaus W, Zhao S, Page CM, Herceg Z, Jarvelin MR, Lahti J, Baccarelli AA, Anderson D, Kachroo P, Relton CL, Bergström A, Eskenazi B, Soomro MH, Vineis P, Snieder H, Bouchard L, Jaddoe VW, Sørensen TIA, Vrijheid M, Arshad SH, Holloway JW, Håberg SE, Magnus P, Dwyer T, Binder EB, DeMeo DL, Vonk JM, Newnham J, Tantisira KG, Kull I, Wiemels JL, Heude B, Sunyer J, Nystad W, Munthe-Kaas MC, Räikkönen K, Oken E, Huang RC, Weiss ST, Antó JM, Bousquet J, Kumar A, Söderhäll C, Almqvist C, Cardenas A, Gruzieva O, Xu CJ, Reese SE, Kere J, Brodin P, Solomon O, Wielscher M, Holland N, Ghantous A, Hivert MF, Felix JF, Koppelman GH, London SJ, and Melén E
- Subjects
- Adolescent, Child, Child, Preschool, DNA blood, Female, Genetic Loci, Humans, Infant, Newborn, Infant, Premature, Male, DNA Methylation, Epigenome, Fetal Development genetics, Premature Birth genetics
- Abstract
Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children., Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung., Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10
- 7 , of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels., Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.- Published
- 2020
- Full Text
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