101. Comparison of central corneal thickness measured by standard ultrasound pachymetry, corneal topography, tono-pachymetry and anterior segment optical coherence tomography
- Author
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Ángelx Sánchez García, José Manuel González Méijome, Javier González-Pérez, Juan Queiruga Piñeiro, and Universidade do Minho
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Corneal Pachymetry ,genetic structures ,Intraclass correlation ,Ciências Naturais::Ciências Físicas ,Ciências Físicas [Ciências Naturais] ,Central corneal thickness ,Cornea ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,symbols.namesake ,Young Adult ,0302 clinical medicine ,Anterior segment optical coherence tomography ,Optical coherence tomography ,Ophthalmology ,Linear regression ,Ultrasound pachymetry ,medicine ,Scheimpflug camera ,Humans ,Prospective Studies ,Interchangeability ,Science & Technology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Non-contact tono-pachymetry ,Corneal Topography ,Reproducibility of Results ,Corneal topography ,Sensory Systems ,Pearson product-moment correlation coefficient ,Healthy Volunteers ,eye diseases ,Contact lens ,Cross-Sectional Studies ,030221 ophthalmology & optometry ,symbols ,Female ,sense organs ,business ,030217 neurology & neurosurgery ,Tomography, Optical Coherence - Abstract
Purpose: To compare central corneal thickness (CCT) measured by standard ultrasound pachymetry (USP), and three non-contact devices in healthy eyes. Methods: A cross-sectional study of CCT measurement in 52 eyes of 52 healthy volunteers was done by a single examiner at Ocular Surface and Contact Lens Laboratory. Three consecutive measurements were done by standard USP, non-contact tono-pachymeter, Pentacam corneal topographer, and Anterior Segment Optical Coherence Tomography (AS-OCT). The mean values were used for assessment. The results were compared using multivariate ANOVA, linear regression, and Pearson correlation. Agreement among the devices was analyzed using mean differences and Bland–Altman analysis with 95% limits of agreement (LoA). Finally, reliability was analyzed using intraclass correlation coefficient (ICC). Results: Mean CCT by ultrasound pachymeter, tono-pachymeter, corneal topographer and AS-OCT were 558.9 ± 31.2 µm, 525.8 ± 43.1 µm, 550.4 ± 30.5 µm, and 545.9 ± 30.5 µm respectively. There was a significant positive correlation between AS-OCT and USP (Pearson correlation = 0.957, p < 0.001), corneal topography and USP (Pearson correlation = 0.965, p < 0.001), and corneal topography and AS-OCT (Pearson correlation = 0.965, p < 0.001). There was a lower correlation between CT-1P tono-pachymeter and the other three modalities. Intraclass correlation coefficients show an excellent reliability between pairs except for CT-1P against the other three instruments that were found moderate. Conclusions: CT-1P tono-pachymeter underestimates CCT measurements compared to Scheimpflug system, AS-OCT device, and USP. Mean CCT among USP, Pentacam and AS-OCT were comparable and had significant linear correlations. In clinical practice, these three modalities could be interchangeable in healthy patients, info:eu-repo/semantics/publishedVersion
- Published
- 2018