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The different slurry transport properties in horizontal pipeline are investigated using a steady three-dimensional hydrodynamic model based on the kinetic theory of granular flow. The flow velocity...

In this study, we carried out an amplified luminescent proximity homogeneous assay (AlphaLISA) to detect sulfonamides (SAs) antibiotic residues in plasma, milk, pork, chicken, and fish. The SAs AlphaLISA method can detect 13 SAs with half‐inhibitory concentration (IC50) 2.11–29.77 ng/ml. The detection level of those SAs was 0.3–41.12 ng/ml in matrices, which satisfied the maximum residue limit (MRL) of the European Union, United States, and China. Our recoveries are in the range of 88% to 116.8% with a coefficient of variation less than 9.3% for different spiked food samples. We observed a good correlation between the AlphaLISA and liquid chromatography–tandem mass spectrometry (LC‐MS/MS) with blood samples from injected rabbits. The established AlphaLISA method provided a no‐washing, rapid, high‐throughput screening tool for SAs in food quality control, which is suitable for small‐volume samples., An amplified luminescent proximity homogeneous assay (AlphaLISA) was carried out in the detection of 13 SAs antibiotic residues in foods with the half‐inhibitory concentration (IC50) values from 2.11 to 29.77 ng/ml. Good correlations were observed between the AlphaLISA and liquid chromatography–tandem mass spectrometry (LC‐MS/MS) results for blood samples from injected rabbits.

The aim of this work was to study an improved solvent evaporation method to prepare poly (lactic acid) (PLA) microspheres via foam-transfer. Since the foaming process and its transfer were critical to the improved method, they have been studied. Additionally, the delivery capability of foams was studied as a function of the oil/water ratio, the stirring rate, the concentration of polyvinyl alcohol (PVA) and ethanol (EtOH) in the aqueous phase (ωPVA, ωEtOH). It was found that foaming varied during the preparation process and it influenced the properties of PLA microspheres. When the oil/water ratio (w/w) ≥ 3:10, stirring rate ≥ 600 r/min, ωPVA ≥ 1 wt%, and ωEtOH = 0 wt%, solvent evaporation was able to produce enough foams for foam-transfer, which helped to deliver more than 89 wt% PLA microspheres to the receiving vessel. However, ωPVA ≤ 0.3 wt% and ωEtOH = 20 wt% were unfavorable for maintaining the spherical shape of PLA microspheres and caused the aggregation. The methodology was further used to prepare azoxystrobin-loaded PLA microspheres successfully with a high encapsulation efficiency of 86.54%. This work is meaningful since it enables an efficient and continuous route to prepare functional biodegradable polymer microspheres.

In this study, vacuum low-pressure carburizing heat treatments were carried out on 18Cr2Ni4WA case-carburized alloy steel. The evolution and phase transformation mechanism of the microstructure of the carburized layer during low-temperature tempering and its effect on the surface hardness were studied. The results showed that the carburized layer of the 18Cr2Ni4WA steel was composed of a large quantity of martensite and retained austenite. The type of martensite matrix changed from acicular martensite to lath martensite from the surface to the core. The hardness of the carburized layer gradually decreased as the carbon content decreased. A thermodynamic model was used to show that the low-carbon retained austenite was easier to transform into martensite at lower temperatures, since the high-carbon retained austenite was more thermally stable than the low-carbon retained austenite. The mechanical stability&mdash, not the thermal stability&mdash, of the retained austenite in the carburized layer dominated after carburizing and quenching, and cryogenic treatment had a limited effect on promoting the martensite formation. During low-temperature tempering, the solid-solution carbon content of the martensite decreased, the compressive stress on the retained austenite was reduced and the mechanical stability of the retained austenite decreased. Therefore, during cooling after low-temperature tempering, the low-carbon retained austenite transformed into martensite, whereas the high-carbon retained austenite still remained in the microstructure. The changes in the martensite matrix hardness had a far greater effect than the transformation of the retained austenite to martensite on the case hardness of the carburized layer.

A solvent evaporation self-motivated synthetic methodology based on foaming-transfer has been developed to fabricate porous polymer microspheres. The novel method is a technical improvement for the traditional solvent evaporation method, in which solvent evaporation enables foam formation and foaming-transfer. Foaming-transfer helps deliver oil droplets from the aqueous phase to the receiving vessel, while phase separation takes place in oil droplets between polymer and porogen to produce porous polymer microspheres. Because of foaming-transfer, the novel method enables a continuous production of polymer microspheres via continuous feeding. Additionally, high efficiency has been observed since solvent evaporation in foams is much quicker than that in the aqueous phase. The methodology was further developed to prepare versatile porous polymer microspheres by introducing extra organic solvents, including ethanol (EtOH), acetone and ethyl acetate. Solvents like EtOH and acetone that have relatively poor compatibilities with oil phase were able to control structure, surface morphology and particle size of polymer microspheres when varying the concentration of solvents; while introducing solvents like ethyl acetate having good miscibility with oil phase hardly changed these properties. It was mainly because the difference on the compatibilities led to different distributions of solvent molecules in the system, which altered the evaporation process of solvent and the surface tension of the system, leading to the variation on structure, particle size and surface roughness. This work is meaningful since it developed an efficient, continuous and versatile method for the production of porous polymer microspheres.

This study has developed a method to produce porous polymeric microspheres in a foam phase. And, the foam phase was a mixture of polymer, organic solvent, porogen and emulsion stabilizer. The process was comprised of a series of constant steps homogenization of the materials, growth of the foam phase and collection of the products. The growth of the foam phase was the key which combined mechanical agitation, solvent evaporation and oil droplets development under increasing temperature. The method has been seen time-saving, high yield and continuous process and it could be useful for industrial production of porous polymer microspheres in a continuous process.