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Purpose: To construct, apply, and evaluate a multidisciplinary approach in teaching radiology to Canadian medical students. Methods: A multidisciplinary team of radiology and other disciplines experts designed an online 5-session course that was delivered to medical students. The topics of each session were clinical cases involving different systems. The target audience was medical students of Canadian schools. Pretests and post-tests were administered before and after each session respectively. An evaluation survey was distributed at the end of the course to gauge students’ perceptions of this experience. Results: An average of 425 medical students attended the live sessions. For each session, 405 students completed both the pre-tests and post-tests. In general, students scored an average of 56% higher on the post-test than on the pre-test. The final course survey was completed by 469 students. The survey results show that more than 98% of students found the course to meet or exceed their expectations. Over 80% of students agreed that the course increased their interest in radiology and about 81% agree that the topics presented were excellent and clinically important. The ratings in the final survey results also indicate that students increased their confidence in basic radiology skills after completing the course. Conclusions: The implementation of an integrative clinical approach to teaching radiology in a virtual setting is achievable. It provides efficient use of educational resources while being accessible by a large number of students across different medical schools.

In this modern era, many technologies have boom but still there are many problems to be deal with and one of the problems we are trying to solve is to help blind people to recognize the currency notes so as to help them avoid any fraudulent and scam by any shopkeeper or by any other means. To overcome this problem, we will build a system which will tell them the amount of the notes and a total amount that they have shown. In our system, we’ve applied Artificial Neural Network (ANNs). The classifier has Convolutional Neural Network (CNN) layers to extract features from the input image. With those features we will classify the images into 7 classes i.e., currency notes. The output will be provided with the help of a speakers that will tell the user the amount as well as the total amount they have shown to the system. Keywords: Currency, Notes, detector, ML, Machine learning, DL. Deep Learning, RaspberryPi

Ground anchors are applicable to Sea-walls, transmission tower, buried pipeline, etc. in which they are subjected to uplift force or tension. The resistance of such uplift or pullout force is obtained using theory of plasticity. The pullout capacity of soil anchor is due to shear strength of surrounding soil, embedded depth, dead weight of plate, etc. Meyerhof and many other has given formulation for such allowable capacity. Many testing methods have been used to study the behavior of anchors (in both sand & clay), including field tests, laboratory tests, numerical analyses (Finite element method), & analytical solutions. Laboratory experiments were performed on relatively large-scale model to find out Ultimate uplift capacity Qu and breakout factor Nq of cohesion less medium. The load-displacement relationship, variation in peak uplift load with varying embedment ratios, and variation in breakout factor with embedding ratio were the core issues of the experiment. Results are compared with the analytical methods to analyze relevance of empirical formula’s results are higher or lower than actual value so it is useful for design of soil anchor plates of Laboratory test shows that as the Embedment ratio & Relative density increases the Uplift load increase. Meyerhof and Adam’s theory give nearer value of ultimate uplift load for loose sand but it gives higher value of ultimate uplift load in medium dense & dense condition of soil in compared with model test’s results in laboratory., {"references":["Akbar K.B. Parmar S.P., Experimental and Analytical study of the uplift capacity of a horizontal plate anchor embedded in geo-reinforced sand.proceedings of first Indian geotechnical Geo-environmental Engineering conf. (2021).","Bhattacharya P, Kumar J.Uplift capacity of anchors in layered sand using finite-element limit analysis: formulation and results. Int J. Geomech 16(3):04015078 (2016).","Adams, J. I. and Hayes, D. C. (1967). \"The uplift capacity of shallow foundations.\" Ont. Hydro Res. Q, Vol. 19, No. 1, pp. 1–13.","Braja M. Das, \"EARTH ANCHORS\", Elsevier (1990).","Das, B. M., and Seeley, G. R., Breakout Resistance of shallow horizontal anchors. Journal of Geotechnical Engineering, Division, ASCE, 101(9), 999-1003(1975).","Deshmukh V.B. Dewaikar D. and Deepankar C . Analysis of rectangular and square anchors in cohesionless soil. Int. Journal of Geotechnical Engg., 04 (1): 79-87 (2010).","Hamed Niroumand and Khairul Anuar Kassim, \"Design and construction of soil anchor Plates\", Elsevier (2016).","IS: 2720 – Part IV, (1985). \"Grain Size Analysis\".","IS: 2720 – Part III/See 2, (1980). \"Determination of Specific Gravity for fine, medium & coarse grain soil\".","IS: 2720 – Part XIV, (1983). \"Determination of Density Index (Relative Density) of Cohesionless Soil\"."]}

Transformer architecture, which is based on self-attention mechanism, revolutionised the field of NLP in 2017. It overcame many of the limitations of sequential and iterative approach of the previous popular architectures like LSTM. Generative Pretrained Transformer (GPT), which is a type of transformer model, is one of the most powerful neural network architectures for the purpose of text summarisation. This paper elaborates how and why GPT-2 can be used for financial news summarisation.

PurposeThe COVID-19 pandemic and technological advancements have enabled employees to telework. Referring to this emerging phenomenon, the authors aim to examine how employees' levels of trust in management mediated by psychological well-being impact their performance as they telework. Deploying the theoretical lens of person-environment misfit, the authors also explore the role of technostress in the trust-wellbeing-performance relationship.Design/methodology/approachThe data was collected from 511 full-time service sector employees across Indian organizations through a structured survey questionnaire. The proposed moderation-mediation model for this study was tested using structural equation modeling and bootstrapping method.FindingsStructural equation modeling results indicate that trust in management significantly impacts employee performance while teleworking. While psychological well-being was observed as a significant mediator, technostress played the moderator role in the trust-performance relationship. The moderated-mediation effect of psychological well-being in the trust-performance relationship was stronger when technostress was low and weaker when technostress was high.Research limitations/implicationsThe authors extend the person-environment misfit theory in the context of telework, highlighting the role of technostress that may impact the trust-wellbeing- performance relationship in such work settings.Practical implicationsThe study informs leaders and managers on balancing delicate aspects such as employee trust and well-being that significantly impact performance as they telework. The authors also highlight the critical role of managers in respecting employees' personal and professional boundaries to alleviate technostress.Originality/valueThe authors make a novel theoretical contribution to the emerging literature on teleworking by examining the trust-psychological wellbeing-performance link and the role of technostress in this relationship.

Ameloblastoma is an aggressively growing jaw tumor with high recurrent properties. Reports on global and racial distribution of ameloblastoma are variable and inconclusive. The role of race and ethnicity on ameloblastoma growth characteristics, genetic mutational profile, and recurrence is also still unclear. The primary aim of this systematic review was to assess genetic, racial, and ethnic distribution of primary and recurrent ameloblastoma from published literature. The secondary aim was to assess potential correlations between ethnicity, genetic mutation, and disparities in ameloblastoma treatment outcomes in Afro-descendants and non-Afro-descendants. Twenty-three eligible articles were selected based on preferred reporting items for systematic review and meta-analysis (PRISMA), and a total of 169 ameloblastoma cases were evaluated. Data on patient demographics, ameloblastoma growth characteristics, and genetic status were collected for quantitative analysis. Among a total of 169 ameloblastoma cases, Afro-descendant patients had higher primary and recurrent ameloblastomas at 15.5% and 4.7% respectively compared to non-Afro-descendant at 10.7% and 1.8% respectively. Additionally, BRAF V600E was positively associated with 48.8% of all ameloblastomas and strong predilection for Afro-descendants. Despite the paucity of information on genetic profile of ameloblastomas in the Afro-descendant patient cohort, this ethnic group still accounted for 2.95% of all BRAF V600E-positive tumors. These suggest that Afro-descendants are understudied regarding ameloblastoma characteristics, genetic profile, and recurrence profile. Mutational analysis of ameloblastoma tumors in Afro-descendants should be promoted.

Background and objective Over the past few decades, new infectious diseases have emerged, and these have played a key role in changing behavior and lifestyle in all age groups. More recently, with the emergence of the coronavirus disease 2019 (COVID-19) pandemic, governments around the world have made unprecedented efforts to contain the epidemic by implementing quarantine measures, social distancing, and isolating infected individuals. Social behavioral adaptations (e.g., social distancing, isolation, etc.) impact children's and adolescents' lifestyle activities and lead to increased incidence of psychosocial problems, worsening of preexisting mental illness, and fears of infection, uncertainty, isolation, and stress. In light of this, this study aimed to assess the impact of COVID-19 on the behaviors and lifestyles of the children and adolescent population of Pakistan. Methodology A cross-sectional study was conducted involving 323 children and adolescents by targeting parents of children and adolescents in the age group of 4-18 years living in Pakistan. The study was conducted from April 2021 to September 2021. A well-designed structured questionnaire was used to collect data about the sociodemographic profile, attitudes, and behavioral factors impacted by COVID-19 in children and adolescents. SPSS Statistics version 23 (IBM, Armonk, NY) was used to enter and analyze data. Results Parents or caregivers of a total of 189 male and 134 female children aged between four and 18 years took part in this study. During COVID-19, the consumption of fast food and fried foods by children and adolescents increased significantly. In this study, out of 323 participants, almost all (289, 89.5%) had increased their screen time significantly. Nearly half of the total individuals experienced the feeling of depression and loneliness during the pandemic. Additionally, some children and adolescents felt fearful when leaving home. COVID-19 lockdowns have led to many changes in children's and adolescents' lifestyle habits. They reduced physical contact with others due to the fear of transmission of COVID-19. Based on our findings, the pandemic and its containment strategies have adversely affected the behaviors, lifestyles, and attitudes of children and adolescents. Conclusion Governments around the world have imposed social distancing during the COVID-19 pandemic, leading to adverse short-term and long-term negative mental health issues such as unhappiness, fear, worry, irritability, depressive symptoms, anxiety, and post-traumatic stress disorder (PTSD). Interventions are needed to focus on building resilience in children and adolescents, addressing their fears and concerns through better communication, encouraging routine and physical activity, and taking measures to alleviate loneliness.

Introduction Communication is the exchange of information through speaking, writing, and other mediums. Speech is the expression of thoughts in spoken words. Language is the principal method that humans use for relaying information; consisting of words conveyed by speech, writing, or gestures. Language is the conceptual processing of communication. Problems in communication or oral motor function are called speech and language disorders. Developmental delay is diagnosed when a child does not attain normal developmental milestones at the expected age. Speech and/or language disorders are amongst the most common developmental difficulties in childhood. Such difficulties are termed 'primary' if they have no known etiology, and 'secondary' if they are caused by another condition such as hearing and neurological impairment, and developmental, behavioral, or emotional difficulties. Objectives The objective of our study was to observe the risk factors for speech and language delay in the children presenting to the speech therapy clinic of a tertiary care hospital in a large urban center. Methodology A cross-sectional study was conducted on 150 children presenting at the speech therapy clinic of Lahore General Hospital from July to August 2021. A well-designed questionnaire was used to collect data about the sociodemographic profile, and biological, developmental, and environmental risk factors of speech and language delay in children. SPSS, version 25 (IBM Corp., Armonk, NY) was used to enter and analyze the data. Results Parents or caretakers of a total of 98 male and 52 female children took part in this study aged 2-11 years. The average age of speech and language delay among the children was 5.65 years, 66.7% of which went to normal school while 31.3% went to special school; 66.7% were from urban areas. Around 60% had middle ear infections, and 34.7% were found to have oropharyngeal anomalies. A history of intrapartum complications was found in 68.4% of children; 46.7% of children had a history of use of a pacifier and 38% had a history of thumb sucking. Nearly 39% of children belonged to a multilingual family environment and 66.7% had a family history of screen viewing for more than two hours. Conclusion The major risk factors contributing to speech and language delay in children are family history of speech and language delay, prolonged sucking habits, male gender, oropharyngeal anomalies, hearing problems, and middle ear infections. Measures should be taken to educate people regarding risk factors, courses, and management of speech and language delay in children.

PurposeDrawing from the Job Demands–Resources (JD-R) theory, this paper aims to identify unique job demands, job resources and personal resources in the context of Indian women flexpatriates (IWFs) and understand how they manage to perform in their short-term international assignments (SIAs).Design/methodology/approachThis study takes a qualitative approach by conducting in-depth interviews of 15 IWFs.FindingsThematic analysis reveals dual-role workload, emotional demands and diluted importance of the assignments as job demands; opportunity for professional growth, social support and combination of work and leisure as job resources, and building up of self-esteem and self-efficacy as personal resources. Also, the unique Indian family structure, Indian women's desire to have “me-time” and zeal to strengthen their identity emerge as differentiating factors for IWFs that enhance their performance.Practical implicationsIWFs are enthusiastic to take up SIAs as it gives them opportunity to enhance their career and strengthen their identity. In addition to their willingness to travel, advance planning of SIAs and profiling of women based on marital status, family type and children can be done for selection.Social implicationsDespite hailing from paternalistic and male-dominating society and facing familial challenges, IWFs find SIAs liberating, which gives them an opportunity to spend some “me-time,” strengthen their identity and enhance their professional growth.Originality/valueThis is the first qualitative study contextualizing flexpatriation with gender and region by studying Indian women professionals.

PurposeThis study examines how emerging market multinational enterprises operating in the service sector manage knowledge and team members in their overseas subsidiaries and what role expatriates play in their operations.Design/methodology/approachThe authors use a multiple case study design and interview 20 senior managers representing 16 Indian IT firm's subsidiaries in Australia. The onsite-offshore concept and the SECI model are used to explain the knowledge management process.FindingsThe findings show that Indian IT firms mostly transfer knowledge from their headquarters in the parent country to their subsidiaries in the host country using the onsite-offshore model where work is divided and coordinated between team members situated between the two locations. Furthermore, the host country subsidiaries have limited independence in decision-making due to a forward, one-way diffusion of knowledge, thus limiting a two-way interaction between the HQ and the subsidiary for opportunities to create and exchange new knowledge.Originality/valueThe study is one of the few to investigate the onsite-offshore phenomenon in service-based emerging market multinational enterprises.

Introduction: Almost 10 million patients suffer from tuberculosis all over the world. Miliary tuberculosis accounts for hardly 1-2 % of total tuberculosis cases but is usually fatal if left untreated. With global epidemic of human immunodeficiency virus (HIV) infection chances of developing tuberculosis disease has also increased. In last few decades MTB has shifted to young adults and elderly who are the most productive members of the society. Fifteen adults were diagnosed to have military tuberculosis during last one year and their data were analysed. Persons living with HIV(PLHIV) accounted for 46% of all cases of military TB. Twelve out of 15 were males. None had meningeal involvement. There was no mortality during hospital stay or follow up till date. High index of suspicion in classical clinical settings and early institution of anti-TB treatment can save lives of patients. Sputum for CBNAAT is very helpful in reaching the diagnosis.

PurposeThis article aims to examine the challenges faced by highly skilled expatriates (i.e. professionals and managers) from the Indian subcontinent (i.e. India and neighboring countries) as they attempt to advance their careers in Australia. Extant literature has revealed significant gaps between policies for skilled migration proposed by governments in developed countries and the response to policies by organizations in those countries. By employing the theories of habitus, disembedding, sensemaking and acculturation as frameworks for analysis, the authors explore and explain how these expatriates settle and integrate into their new lives and careers as they resolve their experience of habitus.Design/methodology/approachThis study employed phenomenology and narrative research techniques using 21 in-depth, semistructured interviews with expatriate professionals from India, Pakistan, Sri Lanka and Bangladesh to explore and examine their expatriation experiences and their occupational progress in Australia.FindingsThe findings reveal that on migrating to Australia, expatriate professionals are uprooted from their home country habitus and thrust into new conditions that cause them to lose their cultural, economic, intellectual and social capital, which further leads them into a state of “disembeddedness.” These highly skilled expatriates then rely on sensemaking and acculturation to resolve their crisis of habitus. The authors also found that gender is a significant factor in this process, as female expatriates faced more career-related barriers compared to their male counterparts.Originality/valueThis article brings into focus previously unexamined avenues of expatriation research and proposes a novel theoretical framework that is instrumental in explaining the settlement and integration process of highly skilled professionals from emerging nations.

Most diseases in society have a complicated epidemiology including various chemical influences such as biology, diet and environmental pollution (EP). “The most dangerous contaminants included particulate matter (PMs), nitrogen oxides, polycyclic aromatic hydrocarbons (PAHs), heavy metals, pesticides, hormones, and polychlorinated biphenyls (PCBs)”. Indeed, there are countless potential contaminants and most have never been assessed as toxic and health hazards, particularly when new chemicals are constantly being developed as a result of interactions with existing chemicals. The effects of these new substances on wellbeing are almost difficult to assess. Previous reports show a wide range of pollution-related diseases. EP has been linked to an elevated prevalence of some malignancies, an increase in all-cause mortality, coronary disease progression, recurring illnesses, “disrupted intellectual and psychomotor development in infants, type 2 diabetes, breathing and immune system as well as brain-degenerative disorders.” EP is a significant reason of mortality and morbidity around the globe, initiating high expenditures in health care. Ecological, biological and toxicological testing is needed to determine the environmental toxins and at what amounts are most dangerous to animals and humans. It will only be possible to enhance environmental security by interdisciplinary collaboration and public awareness-raising programs.

According to the World Health Organization (WHO), particulate matter (PM) contamination causes around 800,000 premature deaths per year, ranking 13th in the world in terms of mortality. However, several findings revealed that the correlation is much stronger and more complicated than previously believed. PM is an element of emissions comprised of very small, acidic, organic compounds, metals, and particulate soil or dust particles or fluid droplets. The most consistent air quality component linked to human illness is PM, which is categorized by size. PM is likely to develop cardiovascular and cerebrovascular disorders due to the mechanisms of inflammation, overt and indirect coagulation activation, and direct translocation to the systemic circulation. The evidence on the cardiovascular system that shows a PM effect is strong. Coronary incidence and mortality rates in populations prone to long-term PM toxicity were significantly higher. Short-term acute emissions increase coronary incidence rates subtly within days of the pollution peak. While some evidence and associated mechanisms show a smaller outcome, the findings for PM’s cortical disease symptoms are not as promising. Respiratory infections are aggravated by exposure to PM. More analysis is needed to clarify the effects of structure, chemistry, and PM for vulnerable groups. The existing research indicates that PM toxicity causes a minor but significant increase in human morbidity and mortality. Air conditioners and particulate matter filters reduced internal heating, and cooking combustion and smoking cessation will reduce indoor PM exposure. These fundamental improvements can be beneficial to patients with acute and chronic cardiovascular and respiratory symptoms. This article provides an overview of the effects of atmospheric airborne suspended particulate matter on population morbidity and mortality. This critical review concludes with public health recommendations based on a summary of the published literature’s findings.

Background: The two most common SARS-CoV-2 vaccines in the UK, BNT162b2 (Pfizer-BioNTech) and ChAdOx1 nCoV-19 (Oxford-AstraZeneca), employ different immunogenic mechanisms. Compared to BNT162b2, two-dose immunisation with ChAdOx1 induces substantially lower peak anti-spike antibody (anti-S) levels and is associated with a higher risk of breakthrough infections. To provide preliminary indication of how a third booster BNT162b2 dose impacts anti-S levels, we performed a cross-sectional analysis using capillary blood samples from vaccinated adults participating in Virus Watch, a prospective community cohort study in England and Wales. Methods: Blood samples were analysed using Roche Elecsys Anti-SARS-CoV-2 S immunoassay. We analysed anti-S levels by week since the third dose for vaccines administered on or after 1 September 2021 and stratified the results by second-dose vaccine type (ChAdOx1 or BNT162b2), age, sex and clinical vulnerability. Results: Anti-S levels peaked at two weeks post-booster for BNT162b2 (22,185 U/mL; 95%CI: 21,406-22,990) and ChAdOx1 second-dose recipients (19,203 U/mL; 95%CI: 18,094-20,377). These were higher than the corresponding peak antibody levels post-second dose for BNT162b2 (12,386 U/mL; 95%CI: 9,801-15,653, week 2) and ChAdOx1 (1,192 U/mL; 95%CI: 818-1735, week 3). No differences emerged by second dose vaccine type, age, sex or clinical vulnerability. Anti-S levels declined post-booster for BNT162b2 (half-life=44 days) and ChAdOx1 second dose recipients (half-life=40 days). These rates of decline were steeper than those post-second dose for BNT162b2 (half-life=54 days) and ChAdOx1 (half-life=80 days). Conclusions: Our findings suggest that peak anti-S levels are higher post-booster than post-second dose, but levels are projected to be similar after six months for BNT162b2 recipients. Higher peak anti-S levels post-booster may partially explain the increased effectiveness of booster vaccination compared to two-dose vaccination against symptomatic infection with the Omicron variant. Faster waning trajectories post-third dose may have implications for the timing of future booster campaigns or four-dose vaccination regimens for the clinically vulnerable.

Plant microRNAs (miRNAs) are short, noncoding RNA molecules that restrict gene expression via posttranscriptional regulation and function in several essential pathways, including development, growth, and stress responses. Accurately identifying miRNAs in populations of small RNA sequencing libraries is a computationally intensive process that has resulted in the misidentification of inaccurately annotated miRNA sequences. In recent years, criteria for miRNA annotation have been refined with the aim to reduce these misannotations. Here, we describe miRador, a miRNA identification tool that utilizes the most up-to-date, community-established criteria for accurate identification of miRNAs in plants. We combined target prediction and Parallel Analysis of RNA Ends (PARE) data to assess the precision of the miRNAs identified by miRador. We compared miRador to other commonly used miRNA prediction tools and found that miRador is at least as precise as other prediction tools while being substantially faster than other tools. miRador should be broadly useful for the plant community to identify and annotate miRNAs in plant genomes.

BackgroundOccupational disparities in COVID-19 vaccine uptake can impact the effectiveness of vaccination programmes and introduce particular risk for vulnerable workers and those with high workplace exposure. This study aimed to investigate COVID-19 vaccine uptake by occupation, including for vulnerable groups and by occupational exposure status.MethodsWe used data from employed or self-employed adults who provided occupational information as part of the Virus Watch prospective cohort study (n=19,595) and linked this to study-obtained information about vulnerability-relevant characteristics (age, medical conditions, obesity status) and work-related COVID-19 exposure based on the Job Exposure Matrix. Participant vaccination status for the first, second, and third dose of any COVID-19 vaccine was obtained based on linkage to national records and study records. We calculated proportions and Sison-Glaz multinomial 95% confidence intervals for vaccine uptake by occupation overall, by vulnerability-relevant characteristics, and by job exposure.FindingsVaccination uptake across occupations ranged from 89-96% for the first dose, 87-94% for the second dose, and 75-86% for the third dose, with transport, trade, service and sales workers persistently demonstrating the lowest uptake. Vulnerable workers tended to demonstrate fewer between-occupational differences in uptake than non-vulnerable workers, although clinically vulnerable transport workers (76%-89% across doses) had lower uptake than several other occupational groups (maximum across doses 86-96%). Workers with low SARS-CoV-2 exposure risk had higher vaccine uptake (86%-96% across doses) than those with elevated or high risk (81-94% across doses).InterpretationDifferential vaccination uptake by occupation, particularly amongst vulnerable and highly-exposed workers, is likely to worsen occupational and related socioeconomic inequalities in infection outcomes. Further investigation into occupational and non-occupational factors influencing differential uptake is required to inform relevant interventions for future COVID-19 booster rollouts and similar vaccination programmes.

Trichilemmal cysts (TCs) are the most common cystic lesions arising on the scalp and up to 2% give rise to a proliferating trichilemmal tumor (PTT). A rare subset of PTTs are termed malignant due to their histologic characteristics, aggressive behavior and potential for metastasis. The histological hallmark of TCs and PTTs is the absence of a granular layer resulting in abrupt trichilemmal keritanization.

Background Cerebral arterial thromboses or ischemic strokes may be caused by cumulative or independent effects of a variety of risk factors. High factor VIII level is one of those important but less known risk factors for arterial and venous thrombosis. We hereby provide a comprehensive review of the role of high factor VIII levels as a risk factor of arterial thrombosis. Moreover, we present our views on inclusion of factor VIII testing in the etiology workup protocol of young patients with ischemic strokes and their treatment with anticoagulant therapy. Case presentation We illustrate a case of 32-year-old North Indian female patient with Ischemic stroke whose only identifiable risk factor was revealed to be an elevated factor VIII level. She was treated with oral anticoagulant with an uneventful follow-up of 6 months. Conclusions Elevated factor VIII levels have their independent and additive effects in causation and prognosis of arterial strokes. We herein discuss the mechanism of this association, the feasibility and yield of routine testing, appropriate cut-off levels, and further treatment protocol especially in young stroke patients.

Two mixed ligand MOFs, {[Zn2(5NO2-IP)2(L)2](H2O)}n (ADES-1) and {[Cd2(5NO2-IP)2(L)2(H2O)4](L)(H2O)(CH3OH)6}n (ADES-2) (where 5NO2-IP = 5-nitroisophthalate and L = (E)-N′-(pyridin-3-ylmethylene)nicotinohydrazide), have been synthesized and characterized via various analytical methods, including SXRD analysis. SXRD analysis revealed that both MOFs adopt an identical two-dimensional network topology. ADES-1 with bulk phase purity has been synthesized via a conventional reflux method and its potential applications as a functional material for reversible dye adsorption and as an efficient heterogeneous catalyst for the Biginelli reaction were exploited. ADES-1 exhibited the rapid and efficient adsorption of both cationic and anionic dye molecules with a slight preference for methyl violet (86%) compared to the other dyes that were investigated. A separation study involving a mixture of dyes and the application of ADES-1 as a column filler for the separation of organic dyes from water are also demonstrated. Moreover, the catalytic performance of ADES-1 towards a multi-component Biginelli reaction to yield 3,4-dihydropyrimidin-2(1H)-ones (DHPM) derivative has been studied. Finally, studies of the utilization of ADES-1 for dye adsorption and its catalytic activity revealed good stability and reusability, enabling it to be a potential functional material, and possible dye adsorption and Biginelli reaction mechanisms are also proposed.

Controlling the product selectivity of a ring-opening hydrolysis reaction remains a great challenge with mineral acids and to an extent with homogeneous catalysts. In addition, even trace amounts of metal impurities in a bioactive product hinder the reaction progress. This has necessitated the development of robust and metal-free catalysts to offer an alternative sustainable route. We report a nitrogen-rich sulfonated carbon as a catalyst derived from an inexpensive precursor for the synthesis of bioactive vicinal diols of spiro-oxindole derivatives. The well-characterized catalyst shows wide generality with different electronic and steric substituents in the substrates under mild reaction conditions. Hot filtration test confirms no leaching of the acid moiety and the catalyst could be reused for four cycles with retention of activities.

In these modern times, the requirement of the energy is not always constant but often periodic. In a hot climatic country like India, a large amount of energy is consumed in cooling application. A heat-exchanger which can store the thermal energy during off-peak hours and use the same energy during peak hours for cooling applications may flatten the periodic energy requirements. Water has a very high value of latent heat of fusion. This latent heat can be utilized to store the thermal energy and use it at a later stage for cooling purposes. The cooling temperature management will be more effective during the phase change process due to the constant fluid temperature. The present study analyzes the heat transfer performance of Ice-Freezing type phase change material (PCM) based heat-exchanger (HEX) during the solidification process. The prediction of solidification time and variation of heat transfer coefficient (HTC) under various configurations is performed. commercialized computational fluid dynamics (CFD) software, Fluent 19 is used to analyze the solidification phenomenon in water. To evaluate the optimum element size, Mesh-independent study is conducted on a single block. Initially, the single block is considered for analyzing the solidification process. The simulations are performed on multiple pipe with varying pitch. The results indicated a drastic change in solidification time as the pitch is decreased. An optimum pitch has to be decided based on the application. The transient variation of the HTC during the solidification process is studied. Initially, during the sensible cooling stage, the HTC decreases at a faster rate. While during the solidification process, the transient variation in HTC is less.

When Virginia expanded Medicaid, many citizens still faced barriers to enrolling in Medicaid. In response, a student-led Medicaid Enrollment Team was created at the HOPES free clinic to provide comprehensive enrollment assistance. In reviewing this program, this paper outlines steps taken that may be used by future enrollment efforts.

Aim: To compare and analyze the clinical adequacy of two topical anesthetic gels, Precaine (8% lidocaine + 0.8% dibucaine) and Precaine B (20% benzocaine) in children before intraoral local anesthetic injections. Materials and Methods: This clinical study included thirty children who needed an inferior alveolar nerve block. They were divided into three groups: Group A: Precaine topical gel group, Group B: Precaine B topical gel Group, Group C: no anesthetic topical gel group (control group). These two effective topical gels were applied before giving intraoral local anesthesia, and afterward, the child's pain response was surveyed utilizing the Wong-Baker Faces Pain Rating Scale. The scores obtained were subjected to statistical analysis. Results: Intergroup comparison showed a significant mean difference between the control group and Precaine group (P > 0.05) as well as Precaine B group (P > 0.05). However, there is no significant difference obtained between Group A and Group B (P < 0.05). Conclusion: It is psychologically and clinically beneficial to apply a topical anesthetic agent before injecting any intraoral anesthesia. In this study, both anesthetic gels showed a nonsignificant difference in reducing inferior alveolar injection pain, but Precaine B shows more promising results than Precaine.

The development of high-efficiency and durable bifunctional electrocatalysts is an important and challenging topic in the area of energy storage/conversion. Herein, we prepared metallic cobalt nanoparticle decorated N-doped graphitic sheets (Co@NGr) by adopting facile pyrolysis of a mixed ligand cobalt-based MOF (CoMOF-2) as a sacrificial template displaying good OER and HER activity. The catalytic material harvested at three different pyrolytic temperatures was characterized by various analytical methods such as PXRD, SEM, TEM, Raman, and XPS analyses. The catalytic activity of the obtained hybrid composite materials towards oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) was studied. Co@NGr-900 was found to be an efficient bifunctional electrocatalyst and 10 mA cm−2 current density was afforded at an overpotential of 390 mV for OER and 340 mV for HER respectively. This study provides insight for the development of cost-effective nonprecious element-based electrocatalysts for water splitting which has relevance in energy storage and conversion. Catalytic performance is governed by the synergistic compositional effect of metallic cobalt/nitrogen-doping in the graphitic carbon increasing the electrical conductivity/active sites of the composite material.

The aim of this research work is to optimize material removal process parameters using CNC turning operation to get the desired value of the surface roughness. With an orthogonal array of L27, the Taguchi approach is used where three levels of each parameter are taken into account, which are cutting speed, feed and nose radius. The experiments were done on EN8D carbon steel and a carbide insert was used for a total run of 27 experiments. Using the surface roughness tester, the roughness values were obtained. Analysis of variance (ANOVA) was executed on Minitab software to recognize the impact of individual machining parameter on surface roughness. Regression equation is prepared from the experimental data and validated by performing random experiment.

Background: Ankle fracture is important in sense that ankle is distal most weight bearing joint and locomotion depends upon stability of ankle mortise. The best option for management of distal fibula fracture remains unclear due to availabity of various implant and different types of fractures. Aim: This study was conducted to know the indication for the two modalities of surgical fixation as this comparative study between close reduction internal fixation and open reduction internal fixation in lower fibula (at syndesmotic level: Weber type B) with lower tibia or medial malleolar fracture. Aim of the study was to perform randomised controlled trial to compare complication and functional modalities in fixation of fibula Materials and Methods: This was a randomised prospective and comparative study for the methods used for management of the lower fibula fracture (Weber type B) done In dept. of orthopaedics, civil hospital, Ahmedabad within time of 1st may 2019 to 1st may 2020 in total of 62 patient in which 39 patient were operated by CRIF and 23 patient operated by ORIF Results: There was significant difference in rate of union as platting was found superior to nailing there were less complication in nailing as compare to platting and better functional score found with nailing. Conclusion: Nailing in lower fibula fracture is a better technique with comminuted ankle fractures that provides better functional outcome with fewer complication than platting. By the syndesmotic point of view there is no such diffrence between crif and orif method for post weight bearing syndesmotic failure. There seems higher chances of ankle stiffness perticularly at syndesmotic level seen after orif method. Keywords: There was no significant difference in syndesmotic diastasis during cyclic loading or at maximal external rotation between the rod and plate groups. Post-cycle external rotation stiffness across the syndesmosis was significantly higher for the locking pla

Watching sound die out A gas of strongly interacting fermionic atoms can serve as a model for systems with densities and energies spanning many orders of magnitude. This universality of physics comes about thanks to a property known as scale invariance. Patel et al. exploited this concept to draw universal conclusions about the attenuation of sound in such systems by studying a homogeneous gas of lithium-6 atoms at very low temperatures (see the Perspective by Schaefer). They found that below the superfluid transition, the sound diffusivity behaved not unlike what has been observed in helium-4, a fluid of strongly interacting bosons. Science , this issue p. 1222 ; see also p. 1162

PurposeThis research examines Indian service managers' perceptions on impact of convergent technologies on their work and resultant organisational performance. The research uses four dimensions – task productivity, task innovation, customer satisfaction and management control – taken together, to investigate the perceived impact of convergent technologies adoption in service organisations context and further examines the resultant organisational performance, based on these dimensions.Design/methodology/approachThe study used partial least squares (PLS) approach to evaluate the measurement model and the structural model. The study was conducted in service industry firms that have made a significant progression towards adopting convergent technologies.FindingsThe results of the study demonstrated higher levels of perceived impact of adoption of convergent technologies on all the four dimensions (i.e. task productivity, task innovation, customer satisfaction and management control). The results of the study also indicate that all the impact dimensions positively influence organisational performance.Research limitations/implicationsThe results of the study suggest that all the impact dimensions positively influence organisation, therefore the service sector managers should be aware about the role of adopting latest convergent technologies so as to enhance the task productivity, innovation, customer satisfaction and management control in their job roles.Practical implicationsThe practical implications of this research are derived on the basis of Future of Work, Labour Market Information Systems, Productivity, Enterprise Development, Enhancing skills of service employees and Employability themes.Originality/valueTo researchers best knowledge is to first study of its kind to evaluate the perceived impact of convergent technologies on organisational performance in Indian context.

Hydrogenation of CO2 to energy-rich products over heterogeneous metal catalysts has gained much attention due to their commercial applications. Specifically, the first-row transition metal catalysts are very rarely reported and discussed for the production of formic acid from the hydrogenation of CO2. Herein, hydrotalcite supported copper metal has shown activity and efficiency to produce formic acid from the hydrogenation of CO2, without adding any additional base or promoter and was effectively recycled 4 times after separating by simple filtration without compromising the formic acid yield. Hydrotalcite supported copper-based catalyst (Cu-HT) was synthesized through the coprecipitation method and used as a heterogeneous catalyst for the hydrogenation of CO2. The precise copper metal content determined by ICP in Cu-HT is 0.00944 mmol. The catalyst afforded maximum TOF, 124 h-1 under the employed reaction conditions: 100 mg catalyst, 60 °C, 60 bar total pressure of CO2/H2 (1:1, p/p) with 60 mL of mixed methanol:water (5:1, v/v) solvent. Cu-HT catalyst was synthesised and thoroughly characterized by FT-IR, PXRD, SEM, TEM, XPS and BET surface area. The first-order kinetic dependence with respect to the catalyst amount, partial pressures of CO2, and of H2 was observed and a plausible reaction mechanism is suggested. Background: CO2 hydrogenation to energy-rich products over heterogeneous metal catalysts has gained much attention due to their commercial applications. Specifically, the first-row transition metal catalysts are very rarely reported and discussed for the production of formic acid from the hydrogenation of CO2. Objective: he aim is to investigate the heterogeneous catalyst systems, using solid soft base hydrotalcite supported Cu metal-based catalyst for effective and selective hydrogenation of CO2 to formic acid. Methods: The Cu –HT catalyst was synthesized and characterized by FT-IR, PXRD, SEM, TEM, XPS and BET surface area in which the precise copper content was 0.00944 mmol. The Cu-HT catalysed hydrogenation of CO2 was carried out in the autoclave. Results: The Cu-HT catalyst afforded maximum TOF of 124 h-1 under the employed reaction conditions: 100 mg catalyst, 60 °C, 60 bar total pressure of CO2/H2 (1:1, p/p) with 60 mL of mixed methanol: water (5:1, v/v) solvent, without adding any additional base or promoter and was recycled 4 times by simple filtration without compromising the formic acid yield. Formation of formic acid was observed to depend on the amount of the catalyst, partial pressures of CO2 and H2, total pressure, temperature and time. Conclusion: Cu-HT based heterogeneous catalyst was found to be efficient for selective hydrogenation of CO2 to formic acid and was effectively recycled four times after elegantly separating by simple filtration.

Traditional in-person discussion alone is often used for preoperative education in Mohs micrographic surgery (MMS). The appropriate use of more modern education techniques is not well defined in the MMS literature. The authors aim to evaluate patient education techniques for MMS, address education in special populations, and highlight opportunities for improvement. We performed a PubMed literature search with keywords “Mohs” and “education”, “teaching”, “understanding”, “explanation”, “preoperative”, or “consent” with no restriction on publication time frame due to literature scarcity. Teledermatology consultation, MMS videos, 3D models, pamphlets/online materials, and shared medical appointments appear to be effective techniques (GRADE B). Analogies are also anecdotally helpful when integrated into traditional verbal education (GRADE C). The role of preoperative educational phone calls is more controversial (GRADE C). Regardless of the education technique utilized, no singular technique entirely replaces the traditional in-person discussion. Having access to multiple modalities can be beneficial for patients, allowing them options to choose their preferred method(s) of education. MMS is a difficult topic to conceptualize, and further research into educational techniques is needed to provide clear guidelines for Mohs surgeons.

The risk and determinants of HCC in patients with primary biliary cholangitis (PBC) are unclear. We conducted a systematic review and meta-analysis of the incidence of HCC and risk factors associated with HCC risk among patients with PBC. We searched PubMed, EMBASE, MEDLINE, Cochrane databases and reference lists from relevant articles to identify cohort studies that examined incidence of HCC in patients with PBC from inception through November 2019. A total of 29 studies including 22,615 patients met the eligibility criteria. The median cohort size was 292 patients followed for an average of 76 months. The pooled incidence rate for patients with PBC was 4.17 per 1000 patient-years (95% CI 3.17–5.47). On subgroup analysis, the incidence of HCC in patients with PBC cirrhosis was 15.7 per 1000 patient-years (95% CI 8.73–28.24). The HCC incidence rate was 9.82 per 1000 person-years (95% CI 5.92–16.28) in men and 3.82 per 1000 person-years (95% CI 2.85–5.11) in women. Cirrhosis is the strongest risk factor for HCC in patients with PBC. Male gender was also a risk factor. Our meta-analysis supports current recommendations of HCC surveillance in patients with PBC cirrhosis. Further studies are needed to evaluate risk factors in this population.

It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case–control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p