151. Survival of patients with early-stage cervical cancer after abdominal or laparoscopic radical hysterectomy: a nationwide cohort study and literature review
- Author
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Hans Trum, Hans H B Wenzel, Ronald P. Zweemer, J.J. Beltman, Petra L.M. Zusterzeel, Hans W. Nijman, Constantijne H. Mom, Ramon G. V. Smolders, Valery E.P.P. Lemmens, Maaike A. van der Aa, Ruud L.M. Bekkers, R. Yigit, Sandrina Lambrechts, Gynecological Oncology, Public Health, Obstetrics and gynaecology, CCA - Cancer Treatment and quality of life, and Amsterdam Reproduction & Development (AR&D)
- Subjects
0301 basic medicine ,Adult ,Cancer Research ,medicine.medical_specialty ,PELVIC LYMPHADENECTOMY ,Uterine cervical neoplasms ,Survival ,Hysterectomy ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Abdomen ,medicine ,Humans ,Radical hysterectomy ,Registries ,Radical Hysterectomy ,Aged ,Neoplasm Staging ,Netherlands ,Retrospective Studies ,Gynecology ,Cervical cancer ,OUTCOMES ,Laparotomy ,Proportional hazards model ,business.industry ,Hazard ratio ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Survival Analysis ,Cancer registry ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,030104 developmental biology ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,Laparoscopy ,business ,Cohort study - Abstract
Contains fulltext : 220978.pdf (Publisher’s version ) (Open Access) AIM: Recently, the safety of laparoscopic radical hysterectomy (LRH) has been called into question in early-stage cervical cancer. This study aimed to evaluate overall survival (OS) and disease-free survival (DFS) in patients treated with abdominal radical hysterectomy (ARH) and LRH for early-stage cervical cancer and to provide a literature review. METHODS: Patients diagnosed between 2010 and 2017 with International Federation of Gynaecology and Obstetrics (2009) stage IA2 with lymphovascular space invasion, IB1 and IIA1, were identified from the Netherlands Cancer Registry. Cox regression with propensity score, based on inverse probability treatment weighting, was applied to examine the effect of surgical approach on 5-year survival and calculate hazard ratios (HR) and 95% confidence intervals (CIs). Literature review included observational studies with (i) analysis on tumours /=30 months (iii) >/=5 events per predictor parameter in multivariable analysis or a propensity score. RESULTS: Of the 1109 patients, LRH was performed in 33%. Higher mortality (9.4% vs. 4.6%) and recurrence (13.1% vs. 7.3%) were observed in ARH than LRH. However, adjusted analyses showed similar DFS (89.4% vs. 90.2%), HR 0.92 [95% CI: 0.52-1.60]) and OS (95.2% vs. 95.5%), HR 0.94 [95% CI: 0.43-2.04]). Analyses on tumour size (/=2 cm) also gave similar survival rates. Review of nine studies showed no distinct advantage of ARH, especially in tumours
- Published
- 2020