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Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in cattle raised in North America. At the feedlot, cattle are subject to metaphylactic treatment with macrolides to prevent BRD, a practice that may promote antimicrobial resistance and has resulted in an urgent need for novel strategies. Mannheimia haemolytica is one of the major bacterial agents of BRD. The inhibitory effects of two amphipathic, α-helical (PRW4, WRL3) and one β-sheet (WK2) antimicrobial peptides were evaluated against multidrug-resistant (MDR) M. haemolytica isolated from Alberta feedlots. WK2 was not cytotoxic against bovine turbinate (BT) cells by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. All three peptides inhibited M. haemolytica, with WK2 being the most efficacious against multiple isolates. At 8–16 µg/mL, WK2 was bactericidal against Mh 330 in broth, and at 32 µg/mL in the presence of BT cells, it reduced the population by 3 logs CFU/mL without causing cytotoxic effects. The membrane integrity of Mh 330 was examined using NPN (1-N-phenylnaphthylamine) and ONPG (o-Nitrophenyl β-D-galactopyranoside), with both the inner and outer membranes being compromised. Thus, WK2 may be a viable alternative to the use of macrolides as part of BRD prevention and treatment strategies. [ABSTRACT FROM AUTHOR]

Background: Evidence of associations between prenatal cannabis use (PCU) and maternal and infant health outcomes remains conflicting amid broad legalization of cannabis across Canada and 40 American states. A critical limitation of existing evidence lies in the non-standardized and crude measurement of prenatal cannabis use (PCU), resulting in high risk of misclassification bias. We developed a standardized tool to comprehensively measure prenatal cannabis use in pregnant populations for research purposes. Methods: We conducted a mixed-methods, patient-oriented tool development and validation study, using a bias-minimizing process. Following an environmental scan and critical appraisal of existing prenatal substance use tools, we recruited pregnant participants via targeted social media advertising and obstetric clinics in Alberta, Canada. We conducted individual in-depth interviews and cognitive interviewing in separate sub-samples, to develop and refine our tool. We assessed convergent and discriminant validity internal consistency and 3-month test–retest reliability, and validated the tool externally against urine-THC bioassays. Results: Two hundred fifty four pregnant women participated. The 9-item Cannabis Exposure in Pregnancy Tool (CEPT) had excellent discriminant (Cohen's kappa = -0.27–0.15) and convergent (Cohen's kappa = 0.72–1.0) validity; as well as high internal consistency (Chronbach's alpha = 0.92), and very good test–retest reliability (weighted Kappa = 0.92, 95% C.I. [0.86–0.97]). The CEPT is valid against urine THC bioassay (sensitivity = 100%, specificity = 82%). Conclusion: The CEPT is a novel, valid and reliable measure of frequency, timing, dose, and mode of PCU, in a contemporary sample of pregnant women. Using CEPT (compared to non-standardized tools) can improve measurement accuracy, and thus the quality of research examining PCU and maternal and child health outcomes. [ABSTRACT FROM AUTHOR]

Background: The COVID-19 (C19) pandemic shocked primary care systems around the world. Those systems responded by supporting patients in the community, and acute care facilities in crisis. In Canada, the Patient Medical Home (PMH) is a widely adopted care model that aims to operationalize the tenets and principles of Primary Health Care (PHC) as developed since the Alma-Ata Declaration. This paper describes how personnel working in and with Primary Care Networks (PCNs) in Alberta, Canada deployed the PMH model and its underlying PHC principles to frame and respond to the C19 shock. Methods: Using purposive and snowball sampling techniques, we interviewed 57 participants who worked in public health and primary care, including community-based family physicians. We used interpretive description to analyze the interviews. Results: PCN staff and physicians described how the PMH model was foundational to normal operations, and how C19 responses were framed by the patient-centric, team-delivered, and continuous care principles the model shares with PHC. Specifically, participants described ensuring access to care, addressing the social determinants of health, being patient centered, and redeploying and expanding PHC teams to accomplish these goals. Discussion: Delivering PHC through the PMH allowed physicians and allied health staff to deliver patient-centered, team-based, holistic bio-medical services to Albertans. In tailoring services to meet the specific social and health needs of the populations served by each PCN, healthcare providers were able to ensure relevant support remained available and accessible. [ABSTRACT FROM AUTHOR]

Background: With increased attention to the importance of integrating the One Health approach into zoonotic disease surveillance and response, a greater understanding of the mechanisms to support effective communication and information sharing across animal and human health sectors is needed. The objectives of this qualitative case study were to describe the communication channels used between human and animal health stakeholders and to identify the elements that have enabled the integration of the One Health approach. Methods: We combined documentary research with interviews with fifteen stakeholders to map the communication channels used in human and swine influenza surveillance in Alberta, Canada, as well as in the response to a human case of H1N2v in 2020. A thematic analysis of the interviews was also used to identify the barriers and facilitators to communication among stakeholders from the animal and human health sectors. Results: When a human case of swine influenza emerged, the response led by the provincial Chief Medical Officer of Health involved players at various levels of government and in the human and animal health sectors. The collaboration of public and animal health laboratories and of the swine sector, in addition to the information available through the surveillance systems in place, was swift and effective. Elements identified as enabling smooth communication between the human and animal health systems included preexisting relationships between the various stakeholders, a relationship of trust between them (e.g., the swine sector and their perception of government structures), the presence of stakeholders acting as permanent liaisons between the ministries of health and agriculture, and stakeholders' understanding of the importance of the One Health approach. Conclusions: Information flows through formal and informal channels and both structural and relational features that can support rapid and effective communication in infectious disease surveillance and outbreak response. [ABSTRACT FROM AUTHOR]

The article offers information on Australian parents' perspectives on commercial packaged toddler snack foods. Topics include the influence of on-pack claims on parental perceptions of healthiness, the impact of marketing claims on product preferences and purchase intentions, and the need for clearer labeling to enable parents to make more informed food choices for their toddlers.

Embedded morphemes are thought to become available during the processing of multi-morphemic words, and impact access to the whole word. According to the edge-aligned embedded word activation theory Grainger & Beyersmann, (2017), embedded morphemes receive activation when the whole word can be decomposed into constituent morphemes. Thus, interfering with morphological decomposition also interferes with access to the embedded morphemes. Numerous studies have examined the effects of interfering with boundary and constituent-internal letters on morphological decomposition by comparing the effect of transposing letters at the morphemic boundary to constituent-internal letters. These studies, which report inconsistent findings, have typically used derived multi-morphemic words (e.g., cleaner), and sometimes use a control replacement letter condition that is not matched to the transposed letter conditions in terms of location. Across five experiments, we test the edge-aligned activation theory by examining the effects of replacing and transposing boundary and constituent-internal letters of compounds. Our findings suggest that replacing boundary letters interferes with access to both embedded constituents, while replacing constituent-internal letters still allows for access to the unaltered constituent, thus compensating for the interference in the altered constituent. Our findings are consistent with the edge-aligned theory with respect to letter replacement, and also imply that letter replacement must match the position of letter transposition when it is used as a control condition. [ABSTRACT FROM AUTHOR]

Energy companies in the Athabasca Oil Sands Region in Alberta, Canada are evaluating the viability of incorporating pit lakes into reclamation closure designs to both sequester tailings and re-integrate the mining lease into the broader natural landscape. Lake Miwasin is a pilot-scale oil sands pit lake encompassed by a constructed catchment where the volume of the water cap is not actively managed. This study compared the water balance during the open water season over two consecutive years with contrasting levels of summertime precipitation. The first year had above average rainfall triggering surface water inflow events that diluted the over-winter water volume by ~ 25%. Flushing of the deepest layers of the water column was restricted from May – September as thermal stratification inhibited complete lake mixing. The second year had below average rainfall resulting in minimal surface water inflow and a drop in lake stage of ~ 30 cm. As the constructed catchment lacks both natural water bodies and connectivity to a legacy groundwater system, freshwater additions to the lake during the summer season were governed by rainfall. This research highlights challenges with constructing sustainable reclamation landscapes within a region characterised by variations in interannual and decadal water cycles. [ABSTRACT FROM AUTHOR]

Aim: To characterize the impact of the COVID‐19 pandemic on diabetes diagnosis using data from Alberta's Tomorrow Project (ATP), a population‐based cohort study of chronic diseases in Alberta, Canada. Materials and Methods: The ATP participants who were free of diabetes on 1 April 2018 were included in the study. A time‐segmented regression model was used to compare incidence rates of diabetes before the COVID‐19 pandemic, during the first two COVID‐19 states of emergency, and in the period when the state of emergency was relaxed, after adjusting for seasonality, sociodemographic factors, socioeconomic status, and lifestyle behaviours. Results: Among 43 705 ATP participants free of diabetes (65.5% females, age 60.4 ± 9.5 years in 2018), the rate of diabetes was 4.75 per 1000 person‐year (PY) during the COVID‐19 pandemic (up to 31 March 2021), which was 32% lower (95% confidence interval [CI] 21%, 42%; p < 0.001) than pre‐pandemic (6.98 per 1000 PY for the period 1 April 2018 to 16 March 2020). In multivariable regression analysis, the first COVID‐19 state of emergency (first wave) was associated with an 87.3% (95% CI −98.6%, 13.9%; p = 0.07) reduction in diabetes diagnosis; this decreasing trend was sustained to the second COVID‐19 state of emergency and no substantial rebound (increase) was observed when the COVID‐19 state of emergency was relaxed. Conclusions: The COVID‐19 public health emergencies had a negative impact on diabetes diagnosis in Alberta. The reduction in diabetes diagnosis was likely due to province‐wide health service disruptions during the COVID‐19 pandemic. Systematic plans to close the post‐COVID‐19 diagnostic gap are required in diabetes to avoid substantial downstream sequelae of undiagnosed disease. [ABSTRACT FROM AUTHOR]

Aim: Canadian guidelines recommend metformin as first‐line therapy for incident uncomplicated type 2 diabetes and the vast majority of patients are treated accordingly. However, only 54% 65% remain on treatment after 1 year, with the highest discontinuation rates within the first 3 months. The purpose of this study was: (a) to identify individual and clinical factors associated with metformin discontinuation among patients with newly diagnosed uncomplicated type 2 diabetes in Alberta, Canada, and (b) describe glycated haemoglobin (HbA1c) trajectories in the first 12 months after initiation of pharmacotherapy, stratified by metformin usage pattern. Materials and Methods: We conducted a retrospective cohort study using linked administrative datasets from 2012 to 2017 to define a cohort of individuals with uncomplicated incident type 2 diabetes. Using logistic regression, we determined individual and clinical characteristics associated with metformin discontinuation. We categorized individuals based on patterns of metformin use and then used mean HbA1c measurements over a 12‐month follow‐up period to determine glycaemic trajectories for each pattern. Results: Characteristics associated with metformin discontinuation were younger age, lower baseline HbA1c and having fewer comorbidities. Sex, income and location (urban/rural) were not significantly associated with metformin discontinuation. Individuals who continued metformin with higher adherence and individuals who discontinued metformin entirely had lowest HbA1c values at 12 months from treatment initiation. Those who changed therapy or had additional therapies added had higher HbA1c values at 12 months. Conclusion: Identifying characteristics associated with discontinuation of metformin and individuals' medication usage patterns provide an opportunity for targeted interventions to support patients' glycaemic management. [ABSTRACT FROM AUTHOR]

Sedimentological and ichnological descriptions of fluvio‐tidal translating point bars are rare, and complex physico‐chemical processes make highly detailed but concise facies descriptions challenging. Herein, mesofacies are defined to describe and interpret three ancient translating point bars from the Lower Cretaceous McMurray Formation, Alberta, Canada. Twenty‐three mesofacies are defined, based on their recurring sedimentological and ichnological characteristics. These mesofacies form the building blocks of beds and bedsets that make up three depositional facies. Facies 1 reflects sand dune migration at the channel base, which grades into inclined heterolithic stratification of Facies 2 and 3. Facies 2 occurs in the centre and seaward portions of the translating point bars and records tide‐dominated deposition of sand and muddy sand during periods of reduced river discharge. Ichnological suites and bioturbation intensities in these beds reflect persistent but variable brackish‐water conditions, fluctuating deposition rates and the deposition of mud. Mud beds are derived from flows with high suspended‐sediment concentrations. Tidally derived mud beds are typically bioturbated with trace fossil suites indicative of slow deposition rates and brackish‐water conditions. Mud deposited during elevated river discharge is burrowed after the dewatering of the bed. Facies 3 occurs at the landward apex of the translating point bar and is marked by sand‐rich and mud‐rich dune deposits with abundant soft‐sediment deformation, indicative of elevated flow velocities and deposition rates. Bioturbation is rare and sporadically distributed owing to unstable substrates. The distribution of the facies reflect the hydrodynamic variations that occurred vertically and laterally across the bar in response to temporal variations in fluvial and tidal flow interaction, as recorded by their mesofacies. The detailed facies analysis strongly suggests that deposition of the three McMurray Formation translating point bars occurred in proximity to the turbidity maximum zone of a fluvio‐tidal channel system. [ABSTRACT FROM AUTHOR]

Background Temozolomide (TMZ) is an oral, systemic chemotherapy used chiefly for treating high-grade glioma. Due to the rising costs of systemic chemotherapy, many jurisdictions have replaced brand name with generic formulations. The aim of this study was to determine whether or not there was difference in the incidence of grade 3 or 4 bone marrow toxicity and median overall survival in patients treated with brand name versus generic TMZ in the province of Alberta, Canada. The province suspended the use of generic TMZ based on preliminary data pointing to excess toxicity. Methods This multicenter, retrospective study included data from patients with newly diagnosed high-grade glioma that received treatment with TMZ in Alberta. Multivariate logistic regression analysis was performed to determine the association between grade 3 or 4 toxicity to generic versus brand name TMZ exposure, ECOG score, and age. Kaplan–Meier survival estimates and log-rank testing were used to determine differences in overall survival between the brand name and generic TMZ cohorts, as well as the cytopenic versus non-cytopenic patients. Furthermore, a screening analysis for grade 3 or 4 bone marrow toxicity was conducted on all de novo glioma patients treated with brand name TMZ after Alberta preemptively stopped generic TMZ. Results Grade 3 or 4 neutropenia and thrombocytopenia were observed in 15% and 19% of patients treated with generic TMZ (n = 156) as compared to 3% and 5% of patients (n = 100) treated with brand name TMZ-treated patients; P=.003 and.001. A trend toward increased median overall survival in glioblastoma patients treated with generic TMZ (13.7 months) versus brand name (15.8 months, P =.178.) was also observed through meeting statistical significance. Based on these results, the province stopped the use of generic TMZ and reverted to the Merck TMZ. An initial review of all new glioma patients (n = 89) treated with Merck TMZ since the province stopped the generic drug demonstrated 3.4% and 10.1% grade 3 or 4 neutropenia, respectively. Conclusions The statistically significant difference in toxicity profile has prompted the province of Alberta to replace generic TMZ with brand name TMZ in high-grade glioma patients pending more detailed analysis. Our study provides evidence supporting the importance of conducting prospective studies on long-term safety for generic chemotherapies. [ABSTRACT FROM AUTHOR]

Summary: Glyphosate‐resistant wheat plants were discovered in southern Alberta in 2017, representing an unauthorized GM release in Canada. The Canadian Food Inspection Agency undertook a series of experiments to characterize and identify this unknown GM wheat, as well as to develop and validate construct‐specific and event‐specific qPCR assays. Results of PCR‐based assays and Sanger sequencing indicated the presence of CaMV 35S promoter (p35S), Rice Actin 1 intron (RactInt1), CP4‐EPSPS gene and nopaline synthase terminator (tNOS) elements in the unknown GM wheat. Genome walking and bead capture strategies, combined with high‐throughput sequencing, were used to identify the 5′ and 3′ wheat junctions and the subsequent mapping of the insert to chromosome 3B of the wheat genome. A probable transformation vector, pMON25497, was recognized, and further testing identified the unknown GM wheat as MON71200 event, one of two events obtained with the pMON25497 vector. The two construct‐specific assays targeted the junctions of the RactInt1 and the CP4‐EPSPS elements and the CP4‐EPSPS and tNOS elements, while the event‐specific assay was located at the 3′ junction into the wheat genome. Both construct‐specific and event‐specific assays had limits of detection of 0.10% of MON71200 in a seed pool. As expected, the two construct‐specific assays cross‐reacted with other wheat and corn events containing the same elements in the same order. No cross‐reactivity was observed for the event‐specific assay. The integrated strategy employed in this study can serve as a model for other cases when facing similar challenges involving unknown GM events. [ABSTRACT FROM AUTHOR]

This article introduces the special issue of REPCS dedicated to the analysis of the restructuring of higher education in Alberta, Canada. It describes the acceleration of the processes of commodification of education and research and the corporatization of institutional governance under the government that took office in April 2019. The Alberta case is situated within the political economy of this petro-state, governed by a right-wing populist party, as well as in relation to the global trends in post-secondary education driven by neoliberal regimes. Further, the article highlights the cracks in the foundations of modern universities that have deeper historical origins than neoliberalism, and that are widening as the governance and raison d'etre of these institutions are challenged by global socio-ecological crises and Indigenous-led decolonization and climate justice movements. Drawing upon firsthand knowledge, as a participant in the struggles at the University of Alberta, as well as extensive research into the government's restructuring agenda and the impacts on the post-secondary sector, the author outlines proposals for reform of the legislative framework governing the relationship between universities and the state, as well as the internal governance of the institution, and assesses the current terrain of agency for such transformation. [ABSTRACT FROM AUTHOR]

This paper presents a new methodology to assist geophysicists in determining the first-break event in a 3-D seismic data set using the well-known technique called dynamic time warping algorithm (DTW), which is usually used to find the optimal alignment between two time-series. We used the optimal path from the cost matrix to identify the first break in the seismogram using a few picks (seeds) made by an interpreter as a reference to perform this task. Furthermore, the data were pre-conditioned by the topographic and linear moveout to improve the method's accuracy. To demonstrate the technique's robustness, first, we applied the methodology in a synthetic seismic data. After demonstrating the efficiency of the algorithm, we applied the aforementioned methodology in the Polo-Miranga 3-D seismic cube located in the Recôncavo sedimentary basin, Bahia-Brazil, and in the seismic data acquired from the Blackfoot field in Alberta, Canada. The high-quality results showed consistency in determining the first break in all ranges of offsets, demonstrating an alternative way to accelerate this seismic processing step. Furthermore, we compared the results obtained by the proposed methodology with an algorithm based on comparing the short-time averages with long-time averages. Finally, we performed the static correction calculation to ensure that the time distortion resulting from the terrain and the low-velocity layer was mitigated in shoot gathers and in the stacked section. [ABSTRACT FROM AUTHOR]

Simple Summary: Cancer is the most common medical condition among Canadians who receive Medical Assistance in Dying (MAID). We aimed to evaluate if people who choose MAID have worse symptoms compared to those who do not. Using data from cancer patients in Alberta who died between July 2017 and January 2019, we carefully compared two groups: those who received MAID (n = 149) and those who did not receive MAID (n = 149). Both groups had worsening symptoms in the year before death. Those who received MAID had slightly worse anxiety and slightly worse lack of appetite than those who did not receive MAID. Overall, our results showed that symptoms between the groups were similar, and that those who received MAID did not have worse overall symptoms. This study highlights the importance of regular symptom screening and early symptom intervention for all patients with advancing cancer. Cancer is the primary underlying condition for most Canadians who are provided Medical Assistance in Dying (MAID). However, it is unknown whether cancer patients who are provided MAID experience disproportionally higher symptom burden compared to those who are not provided MAID. Thus, we used a propensity-score-matched cohort design to evaluate longitudinal symptom trajectories over the last 12 months of patients' lives, comparing cancer patients in Alberta who were and were not provided MAID. We utilized routinely collected retrospective Patient-Reported Outcomes (PROs) data from the Edmonton Symptom Assessment System (ESAS-r) reported by Albertans with cancer who died between July 2017 and January 2019. The data were analyzed using mixed-effect models for repeated measures to compare differences in symptom trajectories between the cohorts over time. Both cohorts experienced increasing severity in all symptoms in the year prior to death (β from 0.086 to 0.231, p ≤.001 to.002). Those in the MAID cohort reported significantly greater anxiety (β = −0.831, p =.044) and greater lack of appetite (β = −0.934, p =.039) compared to those in the non-MAID cohort. The majority (65.8%) of patients who received MAID submitted their request for MAID within one month of their death. Overall, the MAID patients did not experience disproportionally higher symptom burden. These results emphasize opportunities to address patient suffering for all patients with cancer through routine collection of PROs as well as targeted and early palliative approaches to care. [ABSTRACT FROM AUTHOR]

Background and purpose: Influenza vaccination is associated with a longer‐term protective effect against stroke; however, it has a short‐term inflammatory response which may increase short‐term risk of stroke. The aim was to investigate the association between influenza vaccination and short‐term risk of stroke in adults. Methods: Administrative data were obtained from the Alberta Health Care Insurance Plan for all adults in Alberta, Canada, from September 2009 to December 2018. The hazard of any stroke (acute ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage and transient ischaemic attack) within 3, 7, 14, 21 and 30 days of influenza vaccination compared to unexposed time was analysed using Andersen−Gill Cox models, with adjustment for age, sex, anticoagulant use, atrial fibrillation, chronic obstructive pulmonary disease, diabetes, hypertension, income quintile, and rural or urban home location. Results: In the entire cohort consisting of 4,141,209 adults (29,687,899 person‐years), 1,769,565 (42.7%) individuals received at least one vaccination. In total 38,126 stroke events were recorded with 1309 occurring within 30 days of a vaccination event. Influenza vaccination was associated with a significantly reduced hazard of stroke within 3 days (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.73–0.93), 7 days (HR 0.87, 95% CI 0.80–0.95), 14 days (HR 0.87, 95% CI 0.81–0.93), 21 days (HR 0.85, 95% CI 0.80–0.91) and 30 days (HR 0.66, 95% CI 0.65–0.68). Conclusions: An increased early risk associated with vaccination was not observed. The risk of stroke was reduced at all time points within 30 days after influenza vaccination. [ABSTRACT FROM AUTHOR]

Our study encompasses the Oil Sands Area (OSA) within northern Alberta, Canada, which has experienced substantial environmental changes over the last decades, in association with natural and anthropogenic disturbances. Using composites of Landsat imagery for 5-year intervals between 2000 and 2020, we performed two parallel geospatial analyses to assess environmental changes, examining landscape metrics and spectral indices. Landscape metrics were calculated from land use/land cover maps derived from a Random Forest supervised classification. Spectral indices included Normalized Difference Vegetation Index (NDVI) and Normalised Difference Built-up Index (NDBI), among others. Both hierarchical zonal analysis of spectral indices and zonal landscape metrics were calculated based upon two different aggregations of nested drainage basin features from hydrologic unit code (HUC - Watersheds of Alberta). Spatial contiguity of changes was evaluated by hotspot analysis. HUCs determined to experience significant changes at coarse aggregation level were examined at finer level. The combination of landscape metrics and zonal analysis provided evidence of substantial, yet localized, areas of changing trends. Mixed forest experienced the most significant changes; urban/barren areas initially increased and later decreased, indicating change both in agricultural and humanmade areas. [ABSTRACT FROM AUTHOR]

BACKGROUND: Insufficient sleep is a growing public health concern. Thirty percent of Canadian children and youth are not meeting national sleep recommendations. Inadequate sleep can negatively influence students' academics and physical and psychosocial health. Schools have been identified as ideal health promotion settings to influence children's health including their sleep behaviors. The objective of this study was to explore teachers' perspectives on sleep behaviors and their role in school‐based sleep promotion. METHODS: Nineteen elementary teachers were purposively sampled from the greater Edmonton area, Alberta, Canada. Interpretive description was used as the guiding method, and data were generated through one‐on‐one semi‐structured interviews. Inductive descriptive thematic analysis was used to identify interview themes. RESULTS: Three themes related to teachers' perspectives on sleep behaviors and school‐based sleep promotion were identified: the importance of students' sleep, prioritizing sleep as part of teaching and learning, and a culture of healthy sleep habits. CONCLUSIONS: This study found that teachers considered sleep to be essential for elementary students' academic success and wellbeing, and a whole school approach was necessary to support a healthy sleep culture in schools. [ABSTRACT FROM AUTHOR]

Objectives: To compare treated to self-reported prevalence of chronic pain (CP) and to estimate health services utilization (HSU) costs of patients treated for CP in Alberta, Canada. Methods: Patients treated for CP were identified by the physician billing codes of health services for CP from the practitioner claims database in fiscal year 2021/22. The treated prevalence of CP (number of these patients divided by the population) was compared to the self-reported prevalence of CP previously estimated (doi:10.1371/journal.pone.0272638). Costs of patients' HSU included costs for general practitioner (GP), specialist, inpatient, emergency department, outpatient clinic services, and prescription drugs. Results: The treated prevalence of CP was 6.0% (4.4% among males and 7.8% among females) which was 30% to 41% of the self-reported prevalence. The highest treated prevalence (7.2%) was found in the age group of 18–64 years, followed by age groups of >64 years (7.0%) and <18 years (2.1%). The average cost per patient per year was $5096 ($5878 for males and $4652 for females), of which hospitalizations accounted for 65.0%, outpatient clinic visits 16.4%, ED visits 9.5%, prescription drugs 4.7%, GP visits 3.9%, and specialist visits 0.4%. The total cost of patients with CP for the health system was $1.37 billion (∼7% of total health expenditure), of which males accounted for 41.7% and females for 58.3%. Discussion: Our findings suggest that the economic burden of CP is considerable and that many people with self-reported CP do not use the public healthcare services. This can be multifactorial, including lack of availability and accessibility of publicly funded services, people's lack of awareness of available services, lower utilization due to COVID-19 pandemic, and reliance on self-management, private services, and alternative treatments. Further studies are warranted to inform future policies and health system initiatives aiming to reduce the burden of CP and improve lives of people living with it. [ABSTRACT FROM AUTHOR]

Prenatal depression is a serious maternal-child health concern. Risk factors and health consequences appear more prevalent in Indigenous communities and ethnic minority groups; however, research on these populations is limited. We examined the following questions: (A) How do pregnant Indigenous women, ethnic minority women, and White women compare on levels of depressive symptoms and possible clinical depression, and on major risk and protective factors? (B) Is non-dominant (non-White) race associated with higher depressive symptoms and possible clinical depression? (C) What factors mediate and moderate the relationship between race and depression? Data were from the All Our Families study (n = 3354 pregnant women from Alberta, Canada). Depressive symptoms were measured with the Edinburgh Postnatal Depression Scale (EPDS). Descriptive statistics and multivariable regression methods were used to assess the hypotheses that Indigenous and ethnic minority women would have significantly higher mean EPDS score estimates and higher proportions scoring above cut-offs for possible clinical depression, relative to White women. The association between race and depressive symptoms was hypothesised to be partially mediated by risk factors of socioeconomics, health background, discrimination, domestic violence, and psychosocial stress. Potential confounders were age, marital status, and parity. Diet and social support were hypothesised as protective buffers between stress and depressive symptoms. A higher proportion of White women were married, had family income over $80,000, were employed, and had adequate social support, relative to other women. They had significantly lower mean depressive symptom score, and a smaller proportion scored above cut-offs for possible clinical depression. The positive association between race and depressive symptoms appeared to be partially mediated by socioeconomic factors and psychosocial stress. Social support appeared to moderate the association between stress and depressive symptoms. Strategies to address socioeconomic status, stress, and social support among racialized minority women may reduce the risk for prenatal depression. [ABSTRACT FROM AUTHOR]

Canola (Brassica napus L.) production is threatened by blackleg disease caused by Leptosphaeria maculans. Disease outcome is determined by interactions among pathogens, plants, farming practices, and environmental factors. Although the gene-for-gene interactions between the pathogen and its plant host are relatively clear, how precisely the pathogen interacts with the environment and farming practices is still poorly understood, making disease forecasting challenging for commercial farmlands. In recent years, artificial intelligence (AI) has been successful in forecasting disease risks based on environmental factors. In this study, we evaluated two AI methods and a data augmentation method to forecast disease risk using a dataset collected from 116 farmlands in Alberta in 2021 and 2022. We first assessed a machine learning model (support vector machine or SVM) and a deep-learning model (convolutional neural network or CNN) to predict blackleg severity based on five weather variables, flea beetle damage, root maggot damage, and crop-rotation variables. Both SVM and CNN predicted the disease risk with an accuracy of over 66%. The data augmentation method did not improve model performance. Flea beetle feeding and maggot damage contribute little to the model's performance, and omitting these data did not appear to affect the results. In contrast, crop rotation contributes substantially to model performance. The five weather variables contribute roughly equally to the model's performance, and removing any of the individual weather variables did not impact prediction ability for both models. [ABSTRACT FROM AUTHOR]

Background: The application of synthetic chemical inputs in current agricultural practices has significantly increased crop production, but their use has caused severe negative consequences on the environment. Humalite is an organic soil amendment that is rich in humic acid and found in large deposits in southern Alberta, Canada. Humic products can enhance nutrient uptake and assimilation in plants by reducing nutrient losses and enhancing bioavailability in the soil. Aim: Here, we evaluated the effects of different humalite rates in the presence of nitrogen, phosphorus, potassium (NPK) at recommended rates on soil nitrogen availability, wheat growth, grain yield, seed nutritional quality, and nitrogen use efficiency (NUE) under controlled environmental conditions. Methods: A series of studies were conducted by applying five different rates of humalite (0, 200, 400, 800, and 1600 kg ha−1) with NPK at recommended rates. Soil nitrogen availability and shoot and root growth parameters were recorded at flowering stage. NUE was calculated based on the grain yield at maturity stage. Results: Plants grown in the presence of humalite augmented root morphological parameters (root length, volume, and surface area), plant biomass (shoot and root), and nutrient uptake (N, P, K, and S) compared to the plants supplied with recommended fertilizer alone. Furthermore, humalite application significantly increased grain yield (14%–19%), seed protein content (23%–30%), and NUE (14%–60%) compared to the fertilizer application alone. Conclusion: These findings suggest that humalite can be used as an organic soil amendment to reduce synthetic fertilizer application and improve plant growth and yield while enhancing fertilizer use efficiency. [ABSTRACT FROM AUTHOR]

Objectives Experience of psychosocial environments by workers entering trade apprenticeships may differ by gender. We aimed to document perceived harassment and to investigate whether this related to mental ill-health. Methods Cohorts of workers in welding and electrical trades were established, women recruited across Canada and men from Alberta. Participants were recontacted every 6 months for up to 3 years (men) or 5 years (women). At each contact, they were asked about symptoms of anxiety and depression made worse by work. After their last regular contact, participants received a "wrap-up" questionnaire that included questions on workplace harassment. In Alberta, respondents who consented were linked to the administrative health database that recorded diagnostic codes for each physician contact. Results One thousand eight hundred and eighty five workers were recruited, 1,001 in welding trades (447 women), and 884 in electrical trades (438 women). One thousand four hundred and nineteen (75.3%) completed a "wrap up" questionnaire, with 1,413 answering questions on harassment. Sixty percent of women and 32% of men reported that they had been harassed. Those who reported harassment had more frequently recorded episodes of anxiety and depression made worse by work in prospective data. In Alberta, 1,242 were successfully matched to administrative health records. Those who reported harassment were more likely to have a physician record of depression since starting their trade. Conclusions Tradeswomen were much more likely than tradesmen to recall incidents of harassment. The results from record linkage, and from prospectively collected reports of anxiety and depression made worse by work, support a conclusion that harassment resulted in poorer mental health. [ABSTRACT FROM AUTHOR]

Noise from oil and gas development is pervasive across many landscapes and creates a novel soundscape that wildlife must adapt to or avoid. In response to anthropogenic noise, many wildlife species alter their vocalizations. Some adjusted vocalizations may promote effective communication in the presence of noise by improving detection and preserving information about the sender's status. However, if adjusted vocalizations fail to improve communication in noise, both missed detections and misinterpretations of vocalizations could impact the fitness of individuals and ultimately contribute to population declines. Baird's sparrow is a species at risk in Canada that adjusts its songs in response to oil well drilling noise by altering whole-song elements such as decreasing the peak frequency of songs (Curry et al., 2017, Bioacoustics, 27 (2), 105–130). We examined the efficacy of these adjusted songs in the mixed-grass prairies of southern Alberta, Canada during the Baird's sparrow breeding season (May–July 2018 and 2019) using a repeated measures study design (N = 69 dyads) in which we simulated territorial intrusions by broadcasting adjusted songs and unadjusted songs in the presence and absence of oil well drilling noise recordings. We found that focal male behaviour was mainly mediated by noise treatment when compared to song treatment. In noisy trials, males sang less, called more and performed more flybys, regardless of song treatment type. However, in noisy trials, males displayed longer song latency in response to unadjusted songs compared to adjusted songs. The results of our novel study suggest that the presence of oil well drilling noise elicits more aggressive territorial defence behaviour in Baird's sparrows or hinders the ability of individuals to locate or assess rivals. Additionally, our results suggest that adjusted songs only partially restore effective communication in noise. • Focal male behaviour was mainly influenced by the presence or absence of noise. • Noise may have caused increased aggression or impaired detection in focal males. • Focal males did not generally discriminate between adjusted and unadjusted songs. • Adjusted songs may partially improve acoustic detection in noise. • Unadjusted songs may experience partial acoustic masking in noise. [ABSTRACT FROM AUTHOR]

Pope Francis's dream for a synodal Church has implications for Catholic schools globally, but what exactly are these consequences? This paper explores Francis's vision in the context of Canadian Catholic schools in Alberta, Saskatchewan, and the Northwest Territories (NWT), where these schools are fully-funded by the government and enroll nearly a quarter million students. Ten exploratory interviews with chief superintendents from these schools—which formed the basis of a larger study—were analyzed to understand potential connections to Francis's vision and his four commitments to synodality: focusing on relationships, a culture of encounter, the essentials of the Christian faith, and local decision-making. The pope differentiates synodality from democratic forms of leadership and demands a communal form of listening and discerning God's Spirit. While the superintendents' style of leadership appeared to mirror synodality in many ways, predominant issues remain to be explored: an emphasis on relationships upends the status quo and gives new directions for the schools; encountering others will inevitably demand prophetic leadership by the system leaders; leading with the essentials of faith will not please everyone in Catholic schooling; and shared authority among the superintendents, bishops, and trustees requires further dialogue. [ABSTRACT FROM AUTHOR]

To determine the minimum effect of strychnine baits placed for wolves in winter during a program targetting Gray Wolf (Canis lupus) in west-central Alberta from 2005 to 2020, I present a summary of all recorded species killed (n = 522). Fewer wolves (n = 245) were killed compared with non-target animals (n = 277), which included 10 mammal and four bird species. These data provide context on the environmental and ethical impacts of using poison as a component of wildlife management. [ABSTRACT FROM AUTHOR]

Research has examined COVID-19's impacts on parks, but little research has studied the pandemic's impact on in-person interpretation. Based on responses from 431 visitors to Alberta's provincial parks before and during the pandemic, this paper investigates how the pandemic affected visitor intentions to attend personal interpretation programs. Intentions to attend programs decreased after the pandemic started, but were greater for respondents who had attended programs the previous season. Key reasons for not attending programs were not to become infected and not to infect others. Intentions to attend programs were greater for males than females, and greater for respondents with an increased education and a larger household income. Despite pandemic concerns, 53% of respondents said that programs should be offered, with highest support for amphitheater shows, followed by guided hikes, point duties, and family events. Park managers should clearly communicate the benefits and safety measures employed for interpretation programs. [ABSTRACT FROM AUTHOR]

Objective: Translocations have increased in recent years to aid in species recovery efforts. This includes translocations outside of species' historical distribution, where threats are less severe. One candidate species for translocation is the Bull Trout Salvelinus confluentus, but few examples of successful translocations (re-establishment or range expansion) have been documented. Here, we describe an example in which 63 Bull Trout were translocated in 1987 to establish a population in fishless Marie Lake, Alberta. Methods: The translocation was monitored through multiple sampling events over the course of 33 years. Sampling techniques included backpack electrofishing, angling, and water quality and habitat assessments. Result: A population estimate suggested that Bull Trout increased by at least fourfold over the first 12 years; fish reached large sizes (692 mm fork length) and old ages (13 years), and the population had multiple age-and length-classes, including juveniles. Bull Trout also had become established within at least 13 km of river outside of Marie Lake by 2019. Conclusion: Although a naturally reproducing population of this at-risk species was established, numerous factors were not considered within this translocation initiative. Most importantly, nonadfluvial Bull Trout from a disparate source population located about 4000 river kilometers away were used for the translocation. Our case study represents a rare example of a successful Bull Trout translocation and highlights considerations that should occur prior to future translocations that are intended to aid in species recovery and preservation. [ABSTRACT FROM AUTHOR]

Granular urea fertilizer applied at planting is prone to nitrogen (N) losses in certain environments. Enhanced efficiency fertilizers (EEFs) are developed to mitigate losses and optimize plant uptake. To determine the benefits of EEFs in grain yield and quality enhancement in Canada Western Red Spring (CWRS) wheat, an experiment was conducted from 2019 to 2022 at eight sites in Alberta and Saskatchewan, Canada. The effects of five N sources [urea; urea + urease inhibitor, N-(n-butyl)thiophosphoric triamide (NBPT); urea + nitrification inhibitor, nitrapyrin; urea + dual-inhibitor, NBPT + dicyandiamide; and polymer-coated urea, ESN® (Environmentally Smart Nitrogen®)] and four N rates (60, 120, 180, and 240 kg N ha−1) on CWRS wheat production were examined. Results indicated that N source affected grain yield in Dark Brown Chernozem soils but not in Black Chernozem or Dark Grey Luvisol soils. In Dark Brown Chernozem soils, a dual inhibitor increased grain yield by 3.1% and 3.9% relative to urea and polymer-coated urea, respectively, while all other EEFs attained similar results. The use of a dual inhibitor EEF led to greater net returns compared to urea and polymer-coated urea in the Dark Brown Chernozem soils. Grain protein concentration increased linearly with increasing N rate from 60 to 240 kg N ha−1. Generally, a rate of 120 kg N ha−1 was optimal for CWRS wheat grown in Canadian prairie conditions when coupled with EEFs, particularly a dual inhibitor, and grain yield and protein were often responsive. [ABSTRACT FROM AUTHOR]

Herbicide resistance in western Canada has increased interest in alternative weed management strategies. Physical impact mills, a form of harvest weed seed control, have been identified as a strategy that may be well suited for Canadian use. The efficacy of the Harrington Seed Destructor, a physical impact mill, was evaluated in 20 producer fields in Alberta on a wide spectrum of weed species over 3 years. Significant differences in weed densities between the physical impact mill treatment and the regular harvest densities were few; however, some population density reductions were observed. Measurable reductions in weed densities may have been limited by the short timeframe of the experiment, the high initial densities of the weeds, or the targeted weed species having dormancy or longer term seedbanks. Additionally, identified knowledge gaps on how best to optimize physical impact mill efficacy may have reduced the efficacy of the physical impact mill in this study. This study showed no conclusive evidence for the efficacy of a physical impact mill on tested weed species under field conditions. However, it did provide a number of important considerations for future studies. [ABSTRACT FROM AUTHOR]

Background: Alcohol use disorder (AUD), the problematic consumption of alcohol, affects 107 million people worldwide. Individuals with AUD experience high morbidity and increased mortality. Nurses practicing in acute care are ideally positioned to deliver quality interventions to patients with AUD, including screening and brief intervention; formal training and assessment of baseline knowledge, attitudes, and perceptions are necessary. Aims and Objectives: The aim of this study was to explore the knowledge, attitudes, and perceptions of acute care nurses caring for patients with AUD. Design: This study used a cross-sectional survey design. Methods: The Survey of Attitudes and Perceptions was completed by 93 nurses working in six acute care centers (seven medicine units) across Alberta. Data were analyzed using descriptive and inferential statistics. Results: Few participants reported receiving any prior structured training on AUD, with the majority reporting limited knowledge of alcohol and the effects of alcohol consumption. Although most participants said that caring for patients with AUD was a part of their professional role, few felt satisfied or motivated to work with this group of patients. Responses to individual questions or subdomains of the survey did not significantly differ by length of time in professional role, employment status, or sex. Conclusion: Our results indicate that nurses need to learn more about caring for patients with AUD. Developing tailored educational interventions that are mindful of the importance of knowledge, support, satisfaction, and motivation is necessary to improve the quality of care for patients with AUD. [ABSTRACT FROM AUTHOR]

In this article, we look at discourses stemming from the legacy of 'Western Hospitality' in the Young Canadians program offered by the Calgary Stampede in Alberta, Canada.Calgary Stampede is an international known rodeo shows organized every July in the province. The Young Canadians, the program examined in this article, is a program where youth learn performance skills in vocals and dance culminating each year with a performance at the Grandstand Show at the Calgary Stampede each July. Youth also follow a curriculum developed by the Calgary Stampede Foundation called the Youth Development Framework, which includes students learning what it means to be a good human. Using a photovoice methodology in addition to interviews with the participants, we looked and gained an understanding of how students were using the idea of being a good human in their everyday lives. In this small study, students explained what it means to be a good human, including being respectful of others, following the rules, and being kind. In using Bourdieu's notion of habitus, field, cultural reproduction and power, we noticed that our participants are also part of a privileged group that is recruited and trained in a specific way in order to reproduce the notion of being a good human amid a discourse of 'Western Hospitality' in a white, middle-class and patriarchal culture. From our critical lens, the legacy of 'Western Hospitality' perpetuated through the Calgary Stampede discourse, needs to open up and intentionally welcome a more diverse and inclusive space to better represent a more realistic view of Canadians. [ABSTRACT FROM AUTHOR]

During space weather events, geomagnetic disturbances (GMDs) induce geoelectric fields which drive geomagnetically induced currents (GICs) through electrically-grounded power transmission lines. Alberta, Canada--located near the auroral zone and thus prone to large GMDs--has a dense network of magnetometer stations and surface impedance measurements to better characterize the GMD and ground conductivity, respectively. GIC monitoring devices were recently installed at five substation transformer neutrals, providing a unique opportunity to compare data to modeled GICs. GICs are modeled across the >240 kV provincial power transmission network during a moderate GMD event on 24 April 2023. GIC monitoring devices measured larger neutral-to-ground currents than expected up to 117 Amps during peak storm time, providing unequivocal evidence linking network GICs with GMDs. The model performs reasonably well (correlation coefficients >0.5; performance parameter >0.15) at four of five substations, but generally underestimates peak GIC values (sometimes by a factor >2), suggesting that the present model underrepresents overall network risk. The model performs poorly at one of the five substations (correlation = 0.46; performance parameter = 0.10), the reasons for which may be due to simplifications and/or unknowns in network parameters. Despite these underestimates, during this GMD, the model predicts the largest GIC at substations located in the northeastern part of the province (240 kV) or around Edmonton (500 kV)--regions which have significant electrical and industrial infrastructure. Further refinement of the network model with transformer resistances, more line and earthing resistances, and/or including lower voltage levels is necessary to improve data fit. [ABSTRACT FROM AUTHOR]

Maps showing the thickness of sediments above the bedrock (depth to bedrock, or DTB) are important for many geoscience studies and are necessary for many hydrogeological, engineering, mining, and forestry applications. However, it can be difficult to accurately estimate DTB in areas with varied topography, like lowland and mountainous terrain, because traditional methods of predicting bedrock elevation often underestimate or overestimate the elevation in rugged or incised terrain. Here, we describe a machine learning spatial prediction approach that uses information from traditional digital elevation model derived estimates of terrain morphometry and satellite imagery, augmented with spatial feature engineering techniques to predict DTB across Alberta, Canada. First, compiled measurements of DTB from borehole lithologs were used to train a natural language model to predict bedrock depth across all available lithologs, significantly increasing the dataset size. The combined data were then used for DTB modelling employing several algorithms (XGBoost, Random forests, and Cubist) and spatial feature engineering techniques, using a combination of geographic coordinates, proximity measures, neighbouring points, and spatially lagged DTB estimates. Finally, the results were contrasted with DTB predictions based on modelled relationships with the auxiliary variables, as well as conventional spatial interpolations using inverse-distance weighting and ordinary kriging methods. The results show that the use of spatially lagged variables to incorporate information from the spatial structure of the training data significantly improves predictive performance compared to using auxiliary predictors and/or geographic coordinates alone. Furthermore, unlike some of the other tested methods such as using neighbouring point locations directly as features, spatially lagged variables did not generate spurious spatial artifacts in the predicted raster maps. The proposed method is demonstrated to produce reliable results in several distinct physiographic sub-regions with contrasting terrain types, as well as at the provincial scale, indicating its broad suitability for DTB mapping in general. [ABSTRACT FROM AUTHOR]

In this study, we intensively measured the longitudinal productivity and survival of 362 commercially managed honey bee colonies in Canada, over a two-year period. A full factorial experimental design was used, whereby two treatments were repeated across apiaries situated in three distinct geographic regions: Northern Alberta, Southern Alberta and Prince Edward Island, each having unique bee management strategies. In the protein supplemented treatment, colonies were continuously provided a commercial protein supplement containing 25% w/w pollen, in addition to any feed normally provided by beekeepers in that region. In the fumagillin treatment, colonies were treated with the label dose of Fumagilin-B® each year during the fall. Neither treatment provided consistent benefits across all sites and dates. Fumagillin was associated with a large increase in honey production only at the Northern Alberta site, while protein supplementation produced an early season increase in brood production only at the Southern Alberta site. The protein supplement provided no long-lasting benefit at any site and was also associated with an increased risk of death and decreased colony size later in the study. Differences in colony survival and productivity among regions, and among colonies within beekeeping operations, were far larger than the effects of either treatment, suggesting that returns from extra feed supplements and fumagillin were highly contextually dependent. We conclude that use of fumagillin is safe and sometimes beneficial, but that beekeepers should only consider excess protein supplementation when natural forage is limiting. [ABSTRACT FROM AUTHOR]

Alberta is located in Western Canada, and is bordered by British Columbia to the west, and Saskatchewan to the east. The province has a history of employing restorative justice practices that date back many years. Today, Alberta has many restorative justice platforms operating across the province. The present study sought to uncover the genesis of restorative justice in Alberta, and specifically, what has contributed to the growth of restorative justice in this province. To do this, we conducted a qualitative study, in which we interviewed 13 Key Informants from across Alberta. Responses to the question of what contributed to the growth of restorative justice in Alberta were coded and analyzed. The findings of this study are categorized into three major themes: Community, Justice System, and Government. Each of these themes explores several topics, such as community engagement and the push from grassroots organizations, the role of courts, RCMP, judges, and other leaders in the justice system, as well as government funding and programming. This presentation also explores the 'restorativeness' of specialized courts such as the Calgary Indigenous Court; a topic that is becoming especially important in recent years. This paper ends with limitations and areas for future research. [ABSTRACT FROM AUTHOR]

Introduction: The 2021 Canadian Cardiovascular Society (CCS) guidelines recommend intensive low-density lipoprotein cholesterol (LDL-C) reduction for patients with atherosclerotic cardiovascular disease (ASCVD). For patients above LDL-C threshold on maximally tolerated statins, adding ezetimibe and/or a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) is recommended. This population-based, real-world study examined cardiovascular (CV) events in patients with ASCVD who are on statins and above current guideline threshold LDL-C levels. Methods: Using administrative health data in Alberta, Canada, we identified patients with myocardial infarction (MI), ischemic stroke (IS), or peripheral artery disease with LDL-C > 1.8 mmol/L on statins between April 1, 2010 and March 31, 2016. Exploratory subgroups included very high-risk patients with ASCVD shown to derive the most benefit from PCSK9i intensification as identified by the CCS guidelines, including those with acute coronary syndrome (ACS) or recent MI. Frequencies and rates of individual and composite CV events (primary outcome: MI, IS, hospitalization for unstable angina, coronary revascularization, cardiovascular death; secondary outcome: MI, IS, CV death) were calculated over follow-up. Results: The study included 32,984 patients with a mean (standard deviation) follow-up of 40.8 (21.0) months. Overall, 17.7% and 15.6% experienced a primary and secondary outcome, respectively, with rates of 5.58 and 4.83 per 100 patient-years, respectively. CV death and MI were the most common events. Subgroups with recurrent MI and comorbid diabetes exhibited higher CV event rates (23.6% and 22.2% had a primary outcome, respectively). Rates of CV events were notably high in patients with ACS or recent MI (49.4% and 54.0% had a primary outcome, respectively). Conclusion: This real-world study confirms that statin-treated high-risk patients with ASCVD and above-threshold LDL-C levels have substantial incidence of recurrent CV events. These findings reinforce the opportunity for lipid-lowering therapy intensification in high-risk patients to levels below guideline-recommended threshold in order to reduce CV risk. [ABSTRACT FROM AUTHOR]

Electrokinetic (EK) consolidation has been proven to effectively consolidate ultra-soft geomaterials, such as coal washeries, mine tailings, oil sands tailings and so on. The conventional consolidation model based on the small strain theory encountered difficulties with these geomaterials due to continuous changes in material properties during consolidation. This research developed a one-dimensional large strain EK (LSEK-1D) consolidation model for ultra-soft geomaterials. The model is validated using experimental laboratory results regarding settlements and times on mature fine oil sand tailings (MFT), a major environmental challenge for the oil industry in Northern Alberta, Canada. Moreover, the effects of initial sample heights and applied current densities on consolidation times are evaluated. The experimental data on consolidation times of MFT is consistent with the LSEK-1D model. The LSEK-1D model was used to find the scale effect of drainage path on the EK consolidation behaviour of MFT. The model can also be used for other ultra-soft geomaterials and to facilitate the geotechnical engineering design for EK application. [ABSTRACT FROM AUTHOR]

Purpose: Unsupervised item-response theory (IRT) models such as polytomous IRT based on recursive partitioning (IRTrees) and mixture IRT (MixIRT) models can be used to assess differential item functioning (DIF) in patient-reported outcome measures (PROMs) when the covariates associated with DIF are unknown a priori. This study examines the consistency of results for IRTrees and MixIRT models. Methods: Data were from 4478 individuals in the Alberta Provincial Project on Outcome Assessment in Coronary Heart Disease registry who received cardiac angiography in Alberta, Canada, and completed the Hospital Anxiety and Depression Scale (HADS) depression subscale items. The partial credit model (PCM) based on recursive partitioning (PCTree) and mixture PCM (MixPCM) were used to identify covariates associated with differential response patterns to HADS depression subscale items. Model covariates included demographic and clinical characteristics. Results: The median (interquartile range) age was 64.5(15.7) years, and 3522(78.5%) patients were male. The PCTree identified 4 terminal nodes (subgroups) defined by smoking status, age, and body mass index. A 3-class PCM fits the data well. The MixPCM latent classes were defined by age, disease indication, smoking status, comorbid diabetes, congestive heart failure, and chronic obstructive pulmonary disease. Conclusion: PCTree and MixPCM were not consistent in detecting covariates associated with differential interpretations of PROM items. Future research will use computer simulations to assess these models' Type I error and statistical power for identifying covariates associated with DIF. [ABSTRACT FROM AUTHOR]

Human alveolar echinococcosis is increasingly documented in Alberta, Canada. Its causative agent, Echinococcus multilocularis (Em), can be transmitted to humans by infected dogs. We assessed the prevalence and associated risk factors for Em infections in domestic dogs in Calgary, Alberta, Canada. In this cross-sectional study that coupled collection and assessment of dog feces with a survey on potential risk factors, 13 of 696 (Bayesian true prevalence, 2.4%; 95% CrI: 1.3–4.0%) individual dogs' feces collected during August and September 2012 were qPCR positive for Em. Sequencing two of these cases indicated that both were from the same Em European strain responsible for human infections in Alberta. Likelihood of intestinal Em was 5.6-times higher in hounds than other breeds, 4.6-times higher in dogs leashed at dog parks than those allowed off-leash, 3.1-times higher in dogs often kept in the backyard during spring and summer months than those rarely in the yard, and 3.3-times higher in dogs living in neighbourhoods bordering Bowmont park than those in other areas of Calgary. This situation warrants surveillance of dog infections as a preventative measure to reduce infections in North America. [ABSTRACT FROM AUTHOR]

Background: Since March 2023, hundreds of fires have burned from coast to coast throughout the country, placing Canada on track to have the worst wildfire season ever recorded. From East to West, provinces such as Quebec, Ontario, Nova Scotia, Alberta, and British Columbia have been particularly affected by large and uncontrollable wildfires. Objectives: The objective of this study was to determine the prevalence of depression symptoms and predictors among residents living in extreme climate conditions during the Canadian wildfires of 2023 in Alberta and Nova Scotia and to update the literature with data related to those wildfires. Methods: A cross-sectional quantitative survey was conducted in this study. REDCap was used to administer an online survey between 14 May and 23 June 2023. Through the Text4Hope program, participants subscribe to receive supportive SMS messages daily. As part of the initial welcome message, participants were invited to complete an online questionnaire, containing demographic information, wildfire-related information, and responses to the Patient Health Questionnaire-9 (PHQ-9) for depression assessment. SPSS version 25 was used to analyze the data. Descriptive, univariate, and multivariate regression analyses were employed. Results: A total of 298 respondents completed the survey out of 1802 who self-subscribed to the Text4Hope program in Alberta and Nova Scotia and received a link to the online survey, producing a response rate of 16.54%. Most of the respondents were females (85.2%, 253), below 40 years of age (28.3%, 84), employed (63.6%, 189), and in a relationship (56.4%, 167). A historical depression diagnosis (OR = 3.15; 95% CI: 1.39–7.14) was a significant predictor of moderate to severe MDD in our study. The unemployed individuals were two times more likely to report moderate to severe symptoms of MDD than employed individuals (OR = 2.46; 95% CI: 1.06–5.67). Among the total sample population, the moderate to severe MDD prevalence was 50.4%, whereas it was 56.1% among those living in areas affected by wildfires. Conclusion: Based on our study findings, unemployment and a history of depression diagnosis were independently significant risk factors associated with the developing moderate to severe MDD symptoms during wildfire disasters. Further research is required to identify robust predictors of mental health disorders in disaster survivors and provide appropriate interventions to the most vulnerable communities and individuals. [ABSTRACT FROM AUTHOR]

The phrase "severely normal" was often used by Premier Ralph Klein in 1990s' Alberta to describe the Albertans he wished to interpellate, and it has had enduring power as a dog whistle by the political right in the province. Against commentators who see it as only a facile populist gesture, in this article the author deploys Foucault's lectures on "racism against the abnormal," together with Ladelle McWhorter's interpretation, to argue that there is a historical and conceptual continuity to "severely normal" that ties back to Alberta's infamous eugenic history. Articulating this genealogy enables the connection of political struggles on the part of sexual minorities, disabled people, members of non-normative families, and Indigenous people and illuminates the biopolitical rhetoric of successive Conservative governments. [ABSTRACT FROM AUTHOR]

Introduction: The aim of the study was to investigate the impact of time interval between start of intravenous thrombolysis (IVT) to start of endovascular thrombectomy (EVT) on stroke outcomes. Methods: Data from the Quality Improvement and Clinical Research (QuICR) provincial stroke registry from Alberta, Canada, were used to identify stroke patients who received IVT and EVT from January 2015 to December 2019. We assessed the impact of the time interval between IVT bolus to EVT puncture (needle-to-puncture times [NPT]) on outcomes. Radiological outcomes included successful initial recanalization (revised Arterial Occlusive Lesion 2b–3), successful initial and final reperfusion (modified thrombolysis in cerebral infarction 2b–3). Clinical outcomes were 90-day modified Rankin Scale (mRS) and mortality. Results: Of the 680 patients, 233 patients (median age: 73, 41% females) received IVT + EVT. Median NPT was 38 min (IQR, 24–60). Arrival during working hours was independently associated with shorter NPT (p < 0.001). Successful initial recanalization and initial and final reperfusion were observed in 12%, 10%, and 83% of patients, respectively. NPT was not associated with initial successful recanalization (OR 0.97 for every 10-min increase of NPT, 95% CI: 0.91–1.04), initial successful reperfusion (OR 1.01, 95% CI: 0.96–1.07), or final successful reperfusion (OR: 1.03, 95% CI: 0.97–1.08). Every 10-min delay in NPT was associated with lower odds of functional independence at 90 days (mRS ≤2; OR: 0.93; 95% CI, 0.88–0.97). Patients with shorter NPT (≤38 min) had lower 90-day mRS scores (median 1 vs. 3; OR: 0.54 [0.31–0.91]) and had lower mortality (6.1% vs. 21.2%; OR, 0.23 [0.10–0.57]) than the longer NPT group. Conclusion: Shorter NPT did not impact reperfusion outcomes but was associated with better clinical outcome. [ABSTRACT FROM AUTHOR]

Background: Staff in long‐term care (LTC) homes have long‐standing stressors, such as short staffing and high workloads. These stressors increased during the COVID‐19 pandemic; better resources are needed to help staff manage stress and well‐being. The purpose of this study was to evaluate the effect of a simple stress management strategy (coherent breathing). Methods: We conducted a pre–post intervention study to evaluate a self‐managed coherent breathing intervention from February to September 2022. The intervention included basic (breathing only) and comprehensive (breathing plus a biofeedback device) groups. Six hundred eighty‐six participants were initially recruited (359 and 327 in the comprehensive and basic groups respectively) from 31 LTC homes in Alberta, Canada. Two hundred fifty‐four participants completed pre‐and post‐intervention questionnaires (142 [55.9%] in comprehensive and 112 [44.1%] in basic). Participants were asked to use coherent breathing based on a schedule increasing from 2 to 10 min daily, 5–7 times a week over 8 weeks. Participants completed self‐administered online questionnaires pre‐ and post‐intervention to assess outcomes—stress, psychological distress, anxiety, depression, resilience, insomnia, compassion satisfaction, compassion fatigue, and burnout. We used a mixed‐effects regression model to test the main effect of time (pre‐ and post‐intervention) and group while testing the interaction between time and group and controlling for covariates. Results: We found statistically significant changes from pre‐ to post‐intervention in stress (b = −2.5, p < 0.001, 95% CI = −3.1, −1.9), anxiety (b = −0.5, p < 0.001, 95% CI = −0.7, −0.3), depression (b = −0.4, p < 0.001, 95% CI = −0.6, −0.2), insomnia (b = −1.5, p < 0.001, 95% CI = −2.1, −0.9), and resilience (b = 0.2, p < 0.001, 95% CI = 0.1, 0.2). We observed no statistically significant differences between the two intervention groups on any outcome. Conclusions: Our findings suggest that coherent breathing is a promising strategy for improving stress‐related outcomes and resilience. This intervention warrants further, more rigorous testing. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Infectious complications after transrectal prostate biopsy have been increasing, driven in large part, by rates of antibiotic resistance to conventional prophylaxis, such as ciprofloxacin. This study was designed to compare conventional antibiotic prophylaxis (oral ciprofloxacin) with ciprofloxacin and fosfomycin combination therapy prior to biopsy. METHODS: This was a retrospective study looking at men between September 2021 and April 2023, who underwent transrectal prostate biopsy at several institutions in Alberta. The primary outcome was infectious complications within 30 days of prostate biopsy. Secondary outcomes included Clostridium difficile infections, urinary retention, gross hematuria, diarrhea, emergency room (ER) visits, hospital admissions, and intensive care unit (ICU) admissions. Data was collected on resistance patterns and pathogens isolated in culture. RESULTS: During the study period, 2168 men underwent transrectal prostate biopsy. A total of 1216 men received ciprofloxacin alone and 877 received fosfomycin and ciprofloxacin. Infectious complications were significantly higher in the ciprofloxacin alone group (5.8% vs. 0.5%, p<0.0001). Thirty-day complications (7.2% vs. 2.1%, p<0.0001), 30-day ER visits (7.1% vs. 1.8%, p<0.0001), and 30-day hospitalizations (2.7% vs. 0.7%, p<0.001) were all higher in the ciprofloxacin alone group. The most isolated pathogen was E. coli in 54/60 (90%). Ciprofloxacin resistance in the isolated pathogens was high, with 52/60 (87%) showing resistance to ciprofloxacin and 51/54 (94%) E. coli strains resistant. No difference was seen in retention, C. difficile infections, bleeding, or diarrhea. CONCLUSIONS: The addition of fosfomycin for antibiotic prophylaxis prior to transrectal prostate biopsy was associated with significant improvement in infectious complications and healthcare utilization. [ABSTRACT FROM AUTHOR]

Background: Low back pain (LBP) is a common condition causing disability and high healthcare costs. Alberta faces challenges with unnecessary referrals to specialists and long wait times. A province‐wide standardized clinical care pathway based on evidence‐based best practices can improve efficiency, reduce wait times, and enhance patient outcomes. Implementing such pathways has shown success in other areas of healthcare in Alberta. This study developed a clinical decision‐making pathway to standardize care and minimize uncertainty in assessment, diagnosis, and management. Methods: A systematic rapid review identified existing tools and evidence that could support a comprehensive LBP clinical decision‐making tool. Forty‐seven healthcare professionals participated in four rounds of a modified Delphi approach to reach consensus on the assessment, diagnosis, and management of patients presenting to primary care with LBP in Alberta, Canada. This project was a collaborative effort between Alberta Health Services' Bone and Joint Health Strategic Clinical Network (BJHSCN) and the Alberta Bone and Joint Health Institute (ABJHI). Results: A province‐wide expert panel consisting of professionals from different health disciplines and regions collaborated to develop an LBP clinical decision‐making tool. This tool presents clinical care pathways for acute, subacute, and chronic LBP. It also provides guidance for history‐taking, physical examination, patient education, and management. Conclusions: This clinical decision‐making tool will help to standardize care, provide guidance on the diagnosis and management of LBP, and assist in clinical decision‐making for primary care providers in both public and private sectors. [ABSTRACT FROM AUTHOR]

Over half of all new cancer cases in Alberta are diagnosed among people aged 65+ years, a group that encompasses vast variation. Patient-reported experience measures are routinely collected within Cancer Care Alberta; however, the specific consideration of the needs and concerns of older Albertans with cancer is lacking. In 2021, 2204 adults who had received treatment at a cancer centre in Alberta completed the Ambulatory Oncology Patient Satisfaction Survey (AOPSS). In this study, we explored the age differences in satisfaction across six dimensions of person-centred care and in the proportions of unmet needs across eight types of issues, with specific attention to older adults. Using three age groups (18–39, 40–64, 65+), only the physical comfort dimension showed significantly lower satisfaction among those aged 65+ years. Using five age groups (18–39, 40–64, 65–74, 75–84, 85+), significantly lower levels of satisfaction were found related to 'physical comfort' for those aged 65–74 and 75–84, 'coordination and continuity of care' for those aged 75–84 and 85+, and 'information, communication, and education' for those aged 85+. Therefore, grouping together all older adults aged 65+ years obscured lower levels of satisfaction with some dimensions of person-centred care among those aged 75–84 and 85+ years. Unmet needs generally increased with age for all types of issues, with significant differences across age groups for emotional, financial, social/family, and sexual health issues. The lower levels of satisfaction and higher proportions of unmet needs call for tailored interventions to promote optimal care experiences and outcomes among older adults receiving cancer care in Alberta and their families. [ABSTRACT FROM AUTHOR]

This commentary provides a detailed overview of the extensive stakeholder engagement efforts critical to the development of the Future of Cancer Impact (FOCI) in Alberta report. The overarching aim of the FOCI report was to support informed and strategic discussions and actions that will help key stakeholders in the province prepare for a future with increasing cancer incidence and survival. Employing a comprehensive approach and a diverse range of engagement activities, insights from a wide spectrum of stakeholders were gathered and subsequently used to shape the content of the report. This inclusive process ensured broad representation of perspectives, contributing to a deeper understanding of the complexities in cancer care. The outcome is a robust, consensus-driven report with recommendations set to drive significant transformations within the healthcare system. These efforts highlight the critical role of extensive, inclusive, and collaborative engagement in shaping healthcare initiatives and advancing discussions crucial for the future of cancer care in Alberta. [ABSTRACT FROM AUTHOR]

(1) Background: This observational cohort study describes the frequency, content, and satisfaction with advance care planning (ACP) conversations with healthcare providers (HCPs), as reported by patients with advanced colorectal cancer. (2) Methods: The patients were recruited from two tertiary cancer centers in Alberta, Canada. Using the My Conversations survey with previously validated questions, the patients were asked about specific ACP elements discussed, with which HCPs these elements were discussed, their satisfaction with these conversations, and whether they had a goals of care designation (GCD) order. We surveyed and analyzed data from the following four time points: enrollment, months 1, 2, and 3. (3) Results: In total, 131 patients were recruited. At enrollment, 24% of patients reported discussing at least one ACP topic. From enrollment to month 3, patients reported a high frequency of discussions (80.2% discussed fears, 71.0% discussed prognosis, 54.2% discussed treatment preferences at least once); however, only 44.3% of patients reported discussing what is important to them in considering health care preferences. Patients reported having ACP conversations most often with their oncologists (84.7%) and cancer clinic nurses (61.8%). Patients reported a high level of satisfaction with their ACP conversations, with over 80% of patients reported feeling heard and understood. From enrollment to month 3, there was an increase in the number of patients with a GCD order from 53% to 74%. (4) Conclusions: Patients reported more frequent conversations compared to the literature and clinical documentation. While the satisfaction with these conversations is high, there is room for quality improvement, particularly in eliciting patients' personal goals for their treatment. [ABSTRACT FROM AUTHOR]

The Community Helpers Programme (CHP) is a peer-helping programme providing youth and young adults with tools to support their peers to problem solve and seek mental health and suicide prevention support. This study aims to evaluate the effectiveness of the provincial programme (primary outcomes = knowledge, self-efficacy; secondary outcome = awareness of stigma) and describe the experience of participants, coordinators, and others. The mixed methods evaluation included a longitudinal panel design outcome evaluation along with follow-up interviews. A series of three surveys collecting participant characteristics, knowledge, self-efficacy, and awareness of stigma at pre-training (T0), post-training (T1), and six-months follow-up (T2) were conducted. Mean group scores were calculated for completers (T0 and T1 completers and T0, T1, and T2 completers). Friedman tests were conducted to assess change over time and follow-up Wilcoxon Signed Rank tests determined the significance of changes in scores between each timepoint. Content analysis was conducted on qualitative data. Participants' knowledge of mental health, suicide, and available supports along with self-efficacy increased from T0 to T1, and declined at T2. Awareness of stigma was high at all timepoints. Themes from the qualitative analysis included skill and knowledge development facilitators (e.g., consideration of learner needs, passionate coordinators, engaged learning approaches), sustaining community helper connectedness (e.g., helpers' network, awareness of and communication with local resources), and role and impact of CHP (e.g., addressing stigma, success stories). This evaluation demonstrated that CHP was effective and offered feedback on experiences, including suggestions on CHP strengths and aspects to explore. [ABSTRACT FROM AUTHOR]