Search

Your search keyword '"Van der Eycken, Erik"' showing total 1,465 results
Start Over Author "Van der Eycken, Erik"
1,465 results on '"Van der Eycken, Erik"'

201. A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

Author

Ermolat'ev, Denis S. and Van der Eycken, Erik V.

Subjects
Amino compounds -- Chemical properties, Imidazole -- Chemical properties, Carbonyl compounds -- Chemical properties, Biological sciences, Chemistry
Abstract

The readily available 2-aminopyrimidines and [alpha]-bromocarbonyl compounds were used as starting material for a new divergent and efficient synthesis of substituted 2-aminoimidazoles. The developed synthetic method could be applied to prepare analogues of different bioactive marine alkaloids bearing a 2-aminoimidazole skeleton.

Published
2008

217. A One-Pot Synthesis of Triazolodiazepines

Author

Hooyberghs, Geert, Van Hove, Sofie, Jacobs, Jeroen, Van Meervelt, Luc, and Van der Eycken, Erik

Abstract

A one-pot sequential A3-coupling-azidation-cyclisation approach leading to potentially biologically active diazepine analogues has been developed. The implementation of the A3-coupling reaction ensures diversity. Attention is given to this so far rarely studied structural motif of fused heterocyclic diazepines. ispartof: European Journal of Organic Chemistry vol:2015 issue:21 pages:4726-4731 status: published

Published
2015
Full Text
View/download PDF

218. Gold and Silver Catalyzed 7-endo-dig Cyclizations for the Synthesis of Oxazepines

Author

Peshkov, Anatoly, Nechaev, Anton, Pereshivko, Olga, Goeman, Jan, Van der Eycken, Johan, Peshkov, Vsevolod, and Van der Eycken, Erik

Abstract

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium-ring oxazepine core. A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. ispartof: European Journal of Organic Chemistry vol:19 issue:19 pages:4190-4197 status: published

Published
2015

219. Diversity-oriented synthesis of β-lactams and γ-lactams via a post-Ugi nucleophilic cyclization: Lewis acids as regioselective switch

Author

Li, Zhenghua, Sharma, Upendra K, Liu, Zhen, Sharma, Nandini, Harvey, Jeremy, and Van der Eycken, Erik

Abstract

Heterocyclic fused α-methylene β-lactams were successfully synthesized by a post-Ugi InIII-catalyzed intramolecular addition reaction. Switching from InCl3 to AlCl3 led to the regioselective synthesis of α,β-unsaturated γ-lactams. Moreover, replacing terminal alkynes by substituted alkynes in the Ugi adducts resulted in the exclusive formation of γ-lactams with both catalytic systems. ispartof: European Journal of Organic Chemistry vol:2015 issue:18 pages:3957-3962 status: published

Published
2015

220. Photoredox-Catalyzed Hydrosulfonylation of Arylallenes

Author

Storozhenko, Olga A., Festa, Alexey A., Detistova, Galina I., Rybakov, Victor B., Varlamov, Alexey V., Van der Eycken, Erik V., and Voskressensky, Leonid G.

Abstract

(Het)Arylallenes undergo hydrosulfonylation under photoredox-catalyzed conditions. The reaction gives vinyl sulfones in a regio- and diastereoselective manner, employing sodium sulfinates as the sulfonyl source and eosin Y as the photocatalyst. Indol-1-yl, pyrrol-1-yl, phenyl, and naphtylallenes might be used. Aliphatic allenes are incompatible with the reaction conditions.

Published
2020
Full Text
View/download PDF

224. Modulation of the Substitution Pattern of 5-Aryl-2-Aminoimidazoles Allows Fine-Tuning of Their Antibiofilm Activity Spectrum and Toxicity

Author

Peeters, Elien, primary, Hooyberghs, Geert, additional, Robijns, Stijn, additional, Waldrant, Kai, additional, De Weerdt, Ami, additional, Delattin, Nicolas, additional, Liebens, Veerle, additional, Kucharíková, Soňa, additional, Tournu, Hélène, additional, Verstraeten, Natalie, additional, Dovgan, Barbara, additional, Girandon, Lenart, additional, Fröhlich, Mirjam, additional, De Brucker, Katrijn, additional, Van Dijck, Patrick, additional, Michiels, Jan, additional, Cammue, Bruno P. A., additional, Thevissen, Karin, additional, Vanderleyden, Jozef, additional, Van der Eycken, Erik, additional, and Steenackers, Hans P., additional

Published
2016
Full Text
View/download PDF

243. Gold-catalyzed post-MCR transformations towards complex (poly)heterocycles.

Author

Sharma, Upendra K., Tian, Guilong, Voskressensky, Leonid G., and Van der Eycken, Erik V.

Subjects
HETEROCYCLIC compounds, GOLD catalysts, PEPTIDES, CHEMICAL reactions, CATALYSIS
Abstract

Graphical abstract This review highlights the recent advances towards post-MCR transformations towards complex (poly)heterocycles based on gold-catalyzed key steps. Post multicomponent reaction (MCR) transformations are one of the most successful methods leading to high structural diversity and molecular complexity. A well-known MCR, the Ugi reaction typically affords a linear peptide backbone, enabling post-Ugi transformations as an elegant solution to rigidify the Ugi adduct into more drug-like species. Not surprisingly, the development of such transformations leading to new structural frameworks has expanded rapidly over the last few years. These reactions have reached an impressive level of performance and versatility, particularly in amalgamation with gold catalysis. This review outlines the developments achieved in the past decade, highlighting the modifications that are performed in a sequential or domino fashion with emphasis on major concepts, synthetic applications of the derived products as well as mechanistic aspects. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

245. A Gold-Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks.

Author

He, Yi, Li, Zhenghua, Robeyns, Koen, Van Meervelt, Luc, and Van der Eycken, Erik V.

Subjects
GOLD catalysts, AROMATIC compound derivatives, PYRAZOLES, PYRAZOLE derivatives, HETEROCYCLIC compounds synthesis, RING formation (Chemistry), REGIOSELECTIVITY (Chemistry)
Abstract

We report herein an efficient gold(I)-catalyzed post-Ugi domino dearomatization/ ipso-cyclization/Michael sequence that enables access to libraries of diverse (hetero)arene-annulated tricyclic heterocycles. This process affords novel complex polycyclic scaffolds in moderate to good yields from readily available acyclic precursors with excellent chemo-, regio-, and diastereoselectivity. The power of this strategy has been demonstrated by the rapid synthesis of 40 highly functionalized polyheterocycles bearing indole, pyrrole, (benzo)furan, (benzo)thiophene, pyrazole, and electron-rich arene groups in two operational steps. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

248. Synthetic Strategies for the Construction of Indolizines and Indolizine‐fused Compounds: Thienoindolizines and Indolizinoindoles

Author

Nevskaya, Alisa A., Zinoveva, Anna D., Van der Eycken, Erik V., and Voskressensky, Leonid G.

Abstract

This paper provides a review on various methodologies developed for the synthesis of different indolizine derivatives and an overview of their application. These include thienoindolizine and indolizino[8,7‐b]indole derivatives. The indolizine nucleus occurs as privileged scaffold of many natural and synthetic molecules with significant biological activity. Fused‐indolizines such as thienoindolizines and indolizinoindole derivatives are of great interest, due to their antitumor, antimicrobial and enzyme inhibitor activity. Because of their widespread use in chemical, medicinal, biological, and materials science research, indolizines and their fused derivatives are attractive synthetic targets in the search for efficient methods for their construction. The approaches to the synthesis, properties and application of various indolizine derivatives and its fused derivatives such as thienoindolizines and indolizinoindoles are summarized in this review. The study focuses on the recent articles on the topics of indolizines and indolizino[8,7‐b]indoles continuing previous works as well as it includes a general review on thienoindolizine derivatives.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results