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2,007 results on '"Zhang, Ya-Nan"'

201. CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination

Author

Wu, Jun-Jun, primary, Chen, Fang-Yuan, additional, Han, Bei-Bei, additional, Zhang, Hong-Qing, additional, Zhao, Lang, additional, Zhang, Zhe-Rui, additional, Li, Juan-Juan, additional, Zhang, Bo-Dou, additional, Zhang, Ya-Nan, additional, Yue, Yu-Xin, additional, Hu, Hong-Guo, additional, Li, Wen-Hao, additional, Zhang, Bo, additional, Chen, Yong-Xiang, additional, Guo, Dong-Sheng, additional, and Li, Yan-Mei, additional

Published
2023
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206. Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response

Author

Liu, Jing, primary, Hu, Yan-Yan, additional, Zhang, Qiu-Yan, additional, Zhang, Ya-Nan, additional, Li, Na, additional, Zhang, Zhe-Rui, additional, Zhan, Shun-Li, additional, Gao, Lei, additional, Deng, Cheng-Lin, additional, Li, Xiao-Dan, additional, Yuan, Shao-Peng, additional, He, Yuan-Qiao, additional, Ye, Han-Qing, additional, and Zhang, Bo, additional

Published
2023
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207. Comparative analysis of the vaginal microbiome of healthy and polycystic ovary syndrome women: a large cross-sectional study

Author

Jin, Congcong, primary, Qin, Lang, additional, Liu, Zheng, additional, Li, Xiao, additional, Gao, Xuan, additional, Cao, Yongzhi, additional, Zhao, Shigang, additional, Wang, Jiaojiao, additional, Han, Ting, additional, Yan, Lei, additional, Song, Jialun, additional, Zhang, Fangfang, additional, Liu, Feifei, additional, Zhang, Yousheng, additional, Huang, Yuzhen, additional, Song, Yuping, additional, Liu, Yanjun, additional, Yao, Zhina, additional, Chen, Honglei, additional, Zhang, Zhenzhen, additional, Zhao, Shengrui, additional, Feng, Yuhan, additional, Zhang, Ya-nan, additional, Qian, Yu, additional, Sun, Tianyong, additional, Feng, Qiang, additional, and Zhao, Han, additional

Published
2023
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209. An Optical Fiber Optofluidic Laser Biosensor for Rapid Hemoglobin Detection Using Organic Dye

Author

Zhang, Hongrui, Han, Bo, Li, Xuegang, Zhao, Yong, and Zhang, Ya-Nan

Abstract

In this article, we reported an optical fiber optofluidic laser (FOFL) biosensor based on thin-walled hollow optical fiber (HOF). HOFs with wall thickness of several microns were fabricated, which integrated both whispering gallery mode (WGM) optical microcavity and microfluid channel for FOFL. Based on the fluorescence quenching caused by the interaction between rhodamine 6G (R6G) and hemoglobin (Hb), FOFL was used to amplify such quenching effect and an FOFL biosensor was constructed to detect Hb concentration. The experimental results showed that the limit of detection (LOD) of 0.7 nM and the dynamic range of three orders of magnitude were obtained within a short assay time on the order of seconds, which were both great improvements over fluorescence detection results. In addition, the designed sensor has the advantages of low-volume sample consumption, simple homogeneous and wash-free process, and reusability. This work may provide a new approach for Hb detection in blood and has the potential to be applied in the diagnosis of some related diseases.

Published
2024
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210. Ultra-Sensitive Optical Fiber Glucose Sensor Based on In-Fiber MZI With Vernier Effect

Author

Zhao, Yong, Li, Like, Han, Bo, Zheng, Wanlu, Li, Xuegang, and Zhang, Ya-nan

Abstract

In this article, an ultra-sensitive optical sensor based on vernier effect for glucose concentration measurement is reported. First of all, the structure of lateral offset single side-hole optical fiber (SSHF) is designed, which can ingeniously excite two integrated parallel Mach-Zehnder interferometers (MZIs) with significantly different free spectral ranges (FSRs). Then, according to the optical path difference (OPD) theory, a novel FSR regulation scheme is proposed to solve the problem that the FSRs of two parallel MZIs are quite different. Finally, two integrated parallel MZIs with similar FSRs are constructed, which are respectively used as reference MZI and sensing MZI, and then vernier effect is formed in this in-fiber structure. An ultra-high refractive index (RI) sensitivity of more than 10, 0000 nm/RIU has been confirmed theoretically and experimentally. In addition, this ultra-sensitive configuration is used for direct measurement of clinically relevant glucose concentration. In the linear range of 0–30 mM, the glucose sensitivity is up to −2.47 nm/mM. The sensing configuration behaves the merits of simple preparation, high sensitivity and compact structure, and has great application potential in biochemical analysis, clinical diagnosis, dynamic process monitoring and other fields.

Published
2024
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214. RNAi‐mediated silencing of SlitPer disrupts sex pheromone communication behavior in Spodoptera litura.

Author

Yang, Hui‐Hui, Li, Jian‐Qiao, Ma, Sai, Yao, Wei‐Chen, Chen, Yu‐Wen, El Wakil, Abeer, Dewer, Youssef, Zhu, Xiu‐Yun, Sun, Liang, and Zhang, Ya‐Nan

Subjects
SPODOPTERA littoralis, PHEROMONES, RNA interference, MOLECULAR clock, INSECT communication, CLOCK genes, FEMALES
Abstract

Background: The 24‐h circadian rhythm is considered crucial for insect sexual communication. However, its molecular mechanisms and signaling pathways, particularly the roles of the clock gene period (Per), remain largely unclear. The sex pheromone communication behavior of Spodoptera litura displays typical circadian rhythm characteristics. Thus, it represents an excellent model for functional analyses of the clock gene Per. Results: In this study, we investigated the potential roles of SlitPer in regulating sex pheromone communication in S. litura using RNA interference, quantitative real‐time polymerase chain reactions (qPCR), gas chromatography, and behavioral assays. The qPCR results showed that the expression levels of SlitPer and two desaturase genes (SlitDes5 and SlitDes11) in the siPer group differed significantly at most time points from those in the siNC group. Dynamic variation in the three major sex pheromone titers and calling behavior of S. litura females in the siPer group was disordered. In addition, the mating rates of siPer S. litura females decreased significantly by 33.33%. Oviposition by mated siPer females was substantially reduced by 84.84%. Conclusion: These findings provide a fundamental basis for elucidating the molecular mechanism by which Per regulates sex pheromone communication behavior in lepidopteran species. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Published
2023
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215. Advances in Optical Fiber Aptasensor for Biochemical Sensing Applications.

Author

Li, Like, Zhang, Ya‐nan, Zhang, Hongrui, Li, Xuegang, and Zhao, Yong

Subjects
*APTAMERS, *OPTICAL fibers, *OPTICAL fiber detectors, *INTELLIGENT sensors, *ELECTROMAGNETIC interference
Abstract

Optical fiber biochemical sensing technology, as a cutting‐edge, multidisciplinary, and universal sensing technology, is gradually becoming the research focus in the field of biochemical sensing. They enjoy distinctive characteristics such as high cost‐effectiveness, flexibility, resistance to electromagnetic interference, and small size and can be used to detect biochemical analytes at ultra‐low concentrations with ultra‐low sample consumption, even when these biochemical analytes are in hard‐to‐reach environments. An aptamer is a DNA or RNA oligonucleotide fragment with a high affinity for the target selected from random sequences. Due to their advantages of simple synthesis, low cost, good stability, good specificity, and strong affinity, they are gradually becoming ideal recognition elements and may replace antibodies as next‐generation target receptors. Therefore, aptamers, as functional materials, are integrated into optical fiber sensors, which are called optical fiber aptasensors, providing new opportunities for the construction of high‐performance and intelligent biochemical sensors. This article aims to review the recent research progress of fiber‐optic aptamer biochemical sensors, with a focus on their sensing mechanisms and applications. Finally, based on the existing deficiencies of fiber‐optic aptamer biochemical sensors and practical requirements, their future development trends are briefly discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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216. Tailoring the Phonon Polaritons in α‐MoO3 via Proton Irradiation.

Author

Zhang, Ya‐Nan, Tang, Yuanjun, Qi, Liujian, Feng, Yanze, Li, Mengda, An, Junru, Wang, Lei, Zhu, Huiping, Li, Bo, Li, Dabing, and Li, Shaojuan

Subjects
*POLARITONS, *PHONONS, *PROTONS, *IRRADIATION, *DIELECTRIC function
Abstract

Phonon polaritons (PhPs) provide new prospects for the development of next generation nanophotonic devices due to the high optical confinement, low optical losses, and long lifetime. It is crucial to modulate the PhPs in already discovered materials in order to utilize PhPs efficiently and increase the device operability. In this work, oriented particle trace structures in α‐MoO3 are generated where the dielectric functions are broken by proton irradiation. Those particle trace structures act as in‐plane boundaries, launching and reflecting PhPs. In‐plane needle‐like PhPs in the intermediate state are obtained and finally the switching‐off of PhPs via increasing the irradiation fluences is achieved. Furthermore, the switching‐off PhPs are partly restored to original state by annealing. The method provides an opportunity to manipulate light at the nanoscale and construct in‐plane PhPs reflectors with the potential to be used for polaritonic devices and circuits. [ABSTRACT FROM AUTHOR]

Published
2023
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217. Ten-Year Outcomes of IMRT With Chemotherapy Versus IMRT Alone for Stage Ⅱ-Ⅳa Nasopharyngeal Carcinoma: A Retrospective Study

Author

Wang Xiao-li, Sun Da-qing, Yang Hui, Li Yang, Li Xiu-feng, Chang Xiao-long, Meng Xiang-di, Zhang Ya-nan, Zhang Yun-xiang, Hao Fu-rong, and Li Jian-wen

Abstract

Background Concurrent chemoradiotherapy (CCRT) is the cornerstone of treatment for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). However, a 10-year survival rate was rarely reported. Methods Clinical efficacies and acute hematologic toxicities of 177 patients newly diagnosed with locoregionally moderate or advanced NPC and treated with intensity-modulated radiation therapy (IMRT) were analyzed retrospectively. The patients were divided into three groups: IMRT alone, CCRT [neoadjuvant chemotherapy (NC) + CCRT, CCRT, NC + CCRT + adjuvant chemotherapy (AC)], and non-CCRT (NC + IMRT + AC, IMRT + AC). Results The median follow-up time was 48.4 months (range, 3.0–178.9 months). The most common acute hematologic toxicities were limited to grade 0–2 (153 cases, 86.4%). The 10-year overall survival (OS), progression-free survival (PFS), locoregional recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were 66.6%, 77.9%, 92.9%, and 83.0%, respectively. A significant difference in OS among the three groups was observed (P = 0.01). CCRT and non-CCRT significantly improved OS compared with IMRT alone, with a 29.9% and 25.8% increase in 10-year OS (P = 0.01), respectively. Conclusions In the era of IMRT, acute hematologic toxicities were well tolerated with chemoradiotherapy for treating NPC, while distant metastasis was the most common failure pattern, especially for patients with N3 stage disease. Compared with IMRT alone, the CCRT scheme (CCRT, NC + CCRT + AC, NC + CCRT) may improve the OS of patients newly diagnosed with locoregionally moderate or advanced NPC, and non-CCRT (NC + IMRT + AC, IMRT + AC) may be an alternative scheme. Additional randomized trials are warranted to confirm the findings.

Published
2023

222. Psychological and neurological predictors of acupuncture effect in patients with chronic pain: a randomized controlled neuroimaging trial

Author

Wang, Xu, primary, Li, Jin-Ling, additional, Wei, Xiao-Ya, additional, Shi, Guang-Xia, additional, Zhang, Na, additional, Tu, Jian-Feng, additional, Yan, Chao-Qun, additional, Zhang, Ya-Nan, additional, Hong, Yue-Ying, additional, Yang, Jing-Wen, additional, Wang, Li-Qiong, additional, and Liu, Cun-Zhi, additional

Published
2023
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226. Occurrence, Distribution, and Ecological Risk Assessment of Pharmaceuticals and Personal Care Products in the Surface Water: A Case Study of Lipu River, Guilin, China

Author

Zhang, Ya-Nan, primary, Huang, Gui-Bin, additional, Zhang, Qin, additional, Bi, Xiao-Qian, additional, Chu, Hang, additional, Liu, Zi-Xuan, additional, Luo, Jun, additional, Bai, Shao-Yuan, additional, Mo, Shengpeng, additional, Jiang, Xin, additional, Wang, Hui, additional, and Fu, mingming, additional

Published
2023
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234. Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster

Author

Zhang, Ya-Nan, primary, Zhang, Hong-Qing, additional, Wang, Gui-Feng, additional, Zhang, Zhe-Rui, additional, Li, Jia-Qi, additional, Chen, Xiao-Ling, additional, Hu, Yan-Yan, additional, Zeng, Xiang-Yue, additional, Shi, Yu-Jia, additional, Wang, Jing, additional, Li, Ying-Hua, additional, Li, Xiao-Dan, additional, Wang, Chun-He, additional, Zhu, Bing, additional, and Zhang, Bo, additional

Published
2023
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238. Potential roles of oxidative distress on neurodegeneration in Parkinson's disease with neuropsychiatric symptoms

Author

Li, Dan-ning, primary, Lian, Teng-hong, additional, Zhang, Wei-Jiao, additional, Zhang, Ya-nan, additional, Guo, Peng, additional, Guan, Hui-ying, additional, Li, Jing-hui, additional, He, Ming-yue, additional, Zhang, Wen-jing, additional, Zhang, Wei-jia, additional, Luo, Dong-mei, additional, Wang, Xiao-min, additional, and Zhang, Wei, additional

Published
2022
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239. Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer

Author

Zhang, Yi-Ming, primary, Zhang, Li-Ying, additional, Li, Yang-Yang, additional, Zhou, Heng, additional, Miao, Zhi-Ming, additional, Liu, Zhi-Wei, additional, Zhou, Gu-Cheng, additional, Zhou, Ting, additional, Niu, Fan, additional, Li, Jing, additional, Hong, Tao, additional, He, Jin-Peng, additional, Ding, Nan, additional, Zhang, Ya-Nan, additional, Hua, Jun-Rui, additional, Wang, Ju-Fang, additional, and Liu, Yong-Qi, additional

Published
2022
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245. Additional file 1 of Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis

Author

Zhang, Caiyun, Wang, Peng, Zhang, Ya’ nan, Lu, Pengpeng, Huang, Xiaodan, Wang, Yinfeng, Ran, Lang, Xin, Huan, Xu, Xiaotong, Gao, Wenjuan, Sun, Yu, Zhang, Li, and Zhang, Guilong

Abstract

Additional file 1: Figure S1. A) The hydrodynamic size of FePt, MOFePt, pLMOFePt-TGO. B) Hydrodynamic size change of pLMOFePt-TGO pLMOFePt-TGO in a different medium. Figure S2.The particle size and polymer dispersity index (PDI) change of pLMOFePt-TGO in (A) distilled water, (B) PBS, and (C) DMEM with standing time. Figure S3. A-F) XPS high-resolution spectra of Fe2p, Pt4f, Si2p, S2p C1s, and full spectra in pLMOFePt-TGO. Figure S4. Zeta potential of FePt, MOFePt,pLMOFePt-TGO. Figure S5. A) Fourier transform infrared spectroscopy of pLMOFePt-TGO. B) Thermogravimetric curve of TAM, MOFePt, and MOFeP-T. C) The UV-vis standard curve of GOx. D) The loading rate of FePt and GOx calculated by ICP-MS analysis and UV-vis standard curve of GOx in E). Figure S6. A) pH value change of different concentration glucose solution treated with pLMOFePt-TGO. B) Cumulative release profile of FePt from pLMOFePt in various pH solutions. The internalization of pLMOFePt in MCF-7 cells: C) low magnification of Bio-TEM observation and D) high magnification of Bio-TEM observation. Figure S7. A) Pharmacokinetic curves of FePt and pLMOFePt analyzed by ICP-MS. B) The standard curve of intracellular acidity obtained by fluorescent probe BCECF-AM. C) The fluorescence spectrum of MCF-7 cells stained with BCECF-AM to assess cellular acidity. Figure S8. The viability of MCF-7 cells treated with pLMOFePt-TGO at the absence and presence of (A) DFOM, (B) Fer-1, (C) NAC, and (D) Z-VAD-FMK. Figure S9. The images of 4T1 cells stained with JC-1 A) and BODIPY B), respectively after treatment with FePt and pLMOFePt-TGO. Figure S10. (A) The tube formation of C166 cells treated with different concentrations of pLMOFePt-TGO; (B) corresponding number of tube formation. Figure S11. H&E staining images of the vital organs in different treatment groups. Figure S12. Ki67 staining images of MCF-7 tumor-bearing mice treated with different samples.

Published
2023
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