201. The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease
- Author
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Andrea Zatelli, Eric Zini, Michele Berlanda, Xavier Roura, Paola D'Ippolito, University of Zurich, and Zatelli, A
- Subjects
medicine.medical_specialty ,10253 Department of Small Animals ,040301 veterinary sciences ,3400 General Veterinary ,030232 urology & nephrology ,Urology ,Benazepril ,ACE-I, CKD, Diet, Proteinuria ,Urine ,urologic and male genital diseases ,0403 veterinary science ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,ACE-I ,CKD ,Diet ,Proteinuria ,Veterinary (all) ,Enalapril ,Blood urea nitrogen ,Creatinine ,Kidney ,630 Agriculture ,General Veterinary ,business.industry ,04 agricultural and veterinary sciences ,medicine.disease ,female genital diseases and pregnancy complications ,Endocrinology ,medicine.anatomical_structure ,chemistry ,QL1-991 ,570 Life sciences ,biology ,Original Article ,medicine.symptom ,business ,Zoology ,medicine.drug ,Kidney disease - Abstract
Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin -converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days. Thereafter, they were randomly assigned to one of 2 groups. Dogs in group A (n=22) received enalapril (0.5 mg/kg, q12h) and in group B (n=22) benazepril (0.5 mg/kg, q24h); in both groups, dogs were fed the same renal diet. After randomization, dogs were monitored for 120 days. Body weight and body condition score (BCS), serum concentrations of creatinine, blood urea nitrogen (BUN), albumin and total proteins, and urine protein-to creatinine (UPC) ratio were compared at different time-points. After 30 days of renal diet, creatinine, BUN and UPC ratio decreased significantly (p
- Published
- 2016