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203. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials

Author

EARLY BREAST CANCER TRIALISTS' COLLABORATIVE GROUP (EBCTCG), Darby, S., Mcgale, P., Correa, C., Taylor, C., Arriagada, R., Clarke, M., Cutter, D., Davies, C., Ewertz, M., Godwin, J., Gray, R., Pierce, L., Whelan, T., Wang, Y., Peto, R., Albain, K, Anderson, S, Arriagada, R, Barlow, W, Bergh, J, Bliss, J, Buyse, M, Cameron, D, Carrasco, E, Clarke, M, Correa, C, Coates, A, Collins, R, Costantino, J, Cutter, D, Cuzick, J, Darby, S, Davidson, N, Davies, C, Davies, K, Delmestri, A, Di Leo, A, Dowsett, M, Elphinstone, P, Evans, V, Ewertz, M, Gelber, R, Gettins, L, Geyer, C, Goldhirsch, A, Godwin, J, Gray, R, Gregory, C, Hayes, D, Hill, C, Ingle, J, Jakesz, R, James, S, Kaufmann, M, Kerr, A, Mackinnon, E, Mcgale, P, Mchugh, T, Norton, L, Ohashi, Y, Paik, S, Pan, Hc, Perez, E, Peto, R, Piccart, M, Pierce, L, Pritchard, K, Pruneri, G, Raina, V, Ravdin, P, Robertson, J, Rutgers, E, Shao, Yf, Swain, S, Taylor, C, Valagussa, P, Viale, G, Whelan, T, Winer, E, Wang, Y, Wood, W, Abe, O, Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Haybittle, Jl, Leonard, Cf, Calais, G, Geraud, P, Collett, V, Sayer, J, Harvey, Vj, Holdaway, Im, Kay, Rg, Mason, Bh, Forbes, Jf, Wilcken, N, Bartsch, R, Dubsky, P, Fesl, C, Fohler, H, Gnant, M, Greil, R, Lang, A, Luschin-Ebengreuth, G, Marth, C, Mlineritsch, B, Samonigg, H, Singer, Cf, Steger, Gg, Stöger, H, Canney, P, Yosef, Hm, Focan, C, Peek, U, Oates, Gd, Powell, J, Durand, M, Mauriac, L, Dolci, S, Larsimont, D, Nogaret, Jm, Philippson, C, Piccart, Mj, Masood, Mb, Parker, D, Price, Jj, Lindsay, Ma, Mackey, J, Martin, M, Hupperets, Ps, Bates, T, Blamey, Rw, Chetty, U, Ellis, Io, Mallon, E, Morgan, Da, Patnick, J, Pinder, S, Olivotto, I, Ragaz, J, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Weiss, Rb, Abu-Zahra, Ht, Portnoj, Sm, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett-Lee, Pj, Mansel, Re, Monypenny, Ij, Gordon, Nh, Davis, Hl, Lehingue, Y, Romestaing, P, Dubois, Jb, Delozier, T, Griffon, B, Mace Lesec'h, J, Rambert, P, Mustacchi, G, Petruzelka, Pribylova, O, Owen, Jr, Harbeck, N, Jänicke, F, Meisner, C, Schmitt, M, Thomssen, C, Meier, P, Shan, Y, Wang, X, Zhao, Db, Chen, Zm, Howell, A, Swindell, R, Burrett, Ja, Hermans, D, Hicks, C, Lay, M, Albano, J, de Oliveira CF, Gervásio, H, Gordilho, J, Johansen, H, Mouridsen, Ht, Gelman, Rs, Harris, Jr, Henderson, C, Shapiro, Cl, Christiansen, P, Ejlertsen, B, Jensen, Mb, Møller, S, Carstensen, B, Palshof, T, Trampisch, Hj, Dalesio, O, de Vries EG, Rodenhuis, S, van Tinteren, H, Comis, Rl, Davidson, Ne, Robert, N, Sledge, G, Solin, Lj, Sparano, Ja, Tormey, Dc, Dixon, Jm, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, Jg, Treurniet-Donker, Ad, van Putten WL, Rotmensz, N, Veronesi, U, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, Jp, van de Velde CJ, Cunningham, Mp, Huovinen, R, Joensuu, H, Costa, A, Tinterri, C, Bonadonna, G, Gianni, L, Goldstein, Lj, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Luporsi, E, Namer, M, Eiermann, W, Hilfrich, J, Jonat, W, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, Ju, Costa, Sd, Eidtmann, H, Gerber, G, Jackisch, C, Loibl, S, von Minckwitz, G, de Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, Mc, Sacco, M, Valentini, M, Mcardle, Cs, Smith, Dc, Stallard, S, Dent, Dm, Gudgeon, Ca, Hacking, A, Murray, E, Panieri, E, Werner, Id, Segui, Ma, Galligioni, E, Lopez, M, Erazo, A, Medina, Jy, Horiguchi, J, Takei, H, Fentiman, Is, Hayward, Jl, Rubens, Rd, Skilton, D, Scheurlen, H, Sohn, Hc, Untch, M, Dafni, U, Markopoulos, C, Dafni, D, Fountzilas, G, Mavroudis, D, Klefstrom, P, Saarto, T, Gallen, M, Margreiter, R, de Lafontan, B, Mihura, J, Roché, H, Asselain, B, Salmon, Rj, Vilcoq, Jr, Bourgier, C, Koscielny, S, Laplanche, A, Lê, Mg, Spielmann, M, A'Hern, R, Ellis, P, Kilburn, L, Yarnold, Jr, Benraadt, J, Kooi, M, van de Velde AO, van Dongen JA, Vermorken, Jb, Castiglione, M, Colleoni, M, Collins, J, Forbes, J, Gelber, Rd, Lindtner, J, Price, Kn, Regan, Mm, Rudenstam, Cm, Senn, Hj, Thuerlimann, B, Bliss, Jm, Chilvers, Ce, Coombes, Rc, Hall, E, Marty, M, Possinger, K, Schmid, P, Wallwiener, D, Foster, L, George, Wd, Stewart, Hj, Stroner, P, Borovik, R, Hayat, H, Inbar, Mj, Robinson, E, Bruzzi, P, Del Mastro, L, Pronzato, P, Sertoli, Mr, Venturini, M, Camerini, T, De Palo, G, Di Mauro MG, Formelli, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Cocconi, G, Colozza, A, Passalacqua, R, Aogi, K, Takashima, S, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, van de Water, W, van Nes JG, Christiaens, R, Neven, P, Paridaens, R, Van den Bogaert, W, Braun, S, Janni, W, Martin, P, Romain, S, Janauer, M, Seifert, M, Sevelda, P, Zielinski, Cc, Hakes, T, Hudis, Ca, Wittes, R, Giokas, G, Kondylis, D, Lissaios, B, de la Huerta, R, Sainz, Mg, Altemus, R, Camphausen, K, Cowan, K, Danforth, D, Lichter, A, Lippman, M, O'Shaughnessy, J, Pierce, Lj, Steinberg, S, Venzon, D, Zujewski, Ja, D'Amico, C, Lioce, M, Paradiso, A, Chapman, Ja, Gelmon, K, Goss, Pe, Levine, Mn, Meyer, R, Parulekar, W, Pater, Jl, Pritchard, Ki, Shepherd, Le, Tu, D, Ohno, S, Anderson, A, Bass, G, Brown, A, Bryant, J, Dignam, J, Fisher, B, Mamounas, Ep, Redmond, C, Wickerham, L, Wolmark, N, Baum, M, Jackson, Im, Palmer, Mk, Ingle, Jn, Suman, Vj, Bengtsson, No, Emdin, S, Jonsson, H, Lythgoe, Jp, Kissin, M, Erikstein, B, Hannisdal, E, Jacobsen, Ab, Varhaug, Je, Gundersen, S, Hauer-Jensen, M, Høst, H, Nissen-Meyer, R, Mitchell, Ak, Robertson, Jf, Ueo, H, Di Palma, M, Mathé, G, Misset, Jl, Levine, M, Morimoto, K, Takatsuka, Y, Crossley, E, Harris, A, Talbot, D, Taylor, M, Martin, Al, di Blasio, B, Ivanov, V, Paltuev, R, Semiglazov, V, Brockschmidt, J, Cooper, Mr, Falkson, Ci, Ashley, S, Makris, A, Powles, Tj, Smith, Ie, Gazet, Jc, Browne, L, Graham, P, Corcoran, N, Deshpande, N, di Martino, L, Douglas, P, Lindtner, A, Notter, G, Bryant, Aj, Ewing, Gh, Firth, La, Krushen-Kosloski, Jl, Anderson, H, Killander, F, Malmström, P, Rydén, L, Arnesson, Lg, Carstensen, J, Dufmats, M, Fohlin, H, Nordenskjöld, B, Söderberg, M, Carpenter, Jt, Murray, N, Royle, Gt, Simmonds, Pd, Crowley, J, Gralow, J, Green, S, Hortobagyi, G, Livingston, R, Martino, S, Osborne, Ck, Adolfsson, J, Bondesson, T, Celebioglu, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Göransson, E, Iiristo, M, Johansson, U, Lenner, E, Löfgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, af Trampe, E, Wadström, C, Maibach, R, Thürlimann, B, Hakama, M, Holli, K, Isola, J, Rouhento, K, Saaristo, R, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, Ah, Fyles, A, Meakin, Jw, Panzarella, T, Bahi, J, Reid, M, Spittle, M, Bishop, H, Bundred, Nj, Forsyth, S, Pinder, Se, Sestak, I, Deutsch, Gp, Kwong, Dl, Pai, Vr, Senanayake, F, Boccardo, F, Rubagotti, A, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, Js, Carlomagno, C, De Laurentiis, M, De Placido, S, Williams, L, Broglio, K, Buzdar, Au, Love, Rr, Ahlgren, J, Garmo, H, Holmberg, L, Liljegren, G, Lindman, H, Wärnberg, F, Asmar, L, Jones, Se, Gluz, O, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, Bk, Chlebowski, Rt, Caffier, H, Mcgale, P, Correa, C, Taylor, C, Arriagada, R, Clarke, M, Cutter, D, Davies, C, Ewertz, M, Godwin, J, Gray, R, Pierce, L, Whelan, T, Wang, Y, Peto, R, Early Breast Cancer Trialists' Collaborative, Group, DE LAURENTIIS, Michelino, DE PLACIDO, Sabino, Carlomagno, Chiara, Darby, S, McGale, P, Interne Geneeskunde, RS: GROW - School for Oncology and Reproduction, Other departments, CCA -Cancer Center Amsterdam, and Radiotherapy

Subjects
Oncology, medicine.medical_specialty, Neoplasm Recurrence, Local - epidemiology, medicine.medical_treatment, Population, Breast Neoplasms, Mastectomy, Segmental, Breast cancer, breast cancer, Internal medicine, medicine, Breast-conserving surgery, Humans, education, skin and connective tissue diseases, radiotherapy, Randomized Controlled Trials as Topic, education.field_of_study, business.industry, Estrogen Antagonists - therapeutic use, Mortality rate, Age Factors, Estrogen Antagonists, General Medicine, Breast Neoplasms - mortality - therapy, medicine.disease, Surgery, Unilateral Breast Neoplasms, Radiation therapy, Clinical trial, meta-analysis, Tamoxifen, Receptors, Estrogen, Lymphatic Metastasis, Female, Radiotherapy, Adjuvant, Neoplasm Grading, Neoplasm Recurrence, Local, business, Mastectomy
Abstract

BACKGROUND: After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk. METHODS: We undertook a meta-analysis of individual patient data for 10,801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease. FINDINGS: Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant) first recurrence from 35.0% to 19.3% (absolute reduction 15.7%, 95% CI 13.7-17.7, 2p/=20%), intermediate (10-19%), or lower (, link_to_OA_fulltext

Published
2011

204. 1801 Neoadjuvant chemotherapy with trastuzumab or lapatinib: Survival analysis of the HER2-positive cohort of the GeparQuinto study (GBG 44)

Author

Untch, M., primary, Von Minckwitz, G., additional, Gerber, B., additional, Eidtmann, H., additional, Rezai, M., additional, Fasching, P.A., additional, Tesch, H., additional, Eggemann, H., additional, Schrader, I., additional, Kittel, K., additional, Hanusch, C., additional, Huober, J., additional, Solbach, C., additional, Jackisch, C., additional, Kunz, G., additional, Blohmer, J., additional, Hauschild, M., additional, Fehm, T., additional, Nekljudova, V., additional, and Loibl, S., additional

Published
2015
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205. Primärtherapie bei Patientinnen mit Mammakarzinom: Evidenz, Kontroversen, Konsens

Author

Untch, M., additional, Harbeck, N., additional, Huober, J., additional, von Minckwitz, G., additional, Gerber, B., additional, Kreipe, H.-H., additional, Liedtke, C., additional, Marschner, N., additional, Möbus, V., additional, Scheithauer, H., additional, Schneeweiss, A., additional, Thomssen, C., additional, Jackisch, C., additional, Beckmann, M., additional, Blohmer, J.-U., additional, Costa, S.-D., additional, Decker, T., additional, Diel, I., additional, Fasching, P., additional, Fehm, T., additional, Janni, W., additional, Lück, H.-J., additional, Maass, N., additional, Scharl, A., additional, and Loibl, S., additional

Published
2015
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206. Primary Therapy of Patients with Early Breast Cancer: Evidence, Controversies, Consensus

Author

Untch, M., additional, Harbeck, N., additional, Huober, J., additional, von Minckwitz, G., additional, Gerber, B., additional, Kreipe, H.-H., additional, Liedtke, C., additional, Marschner, N., additional, Möbus, V., additional, Scheithauer, H., additional, Schneeweiss, A., additional, Thomssen, C., additional, Jackisch, C., additional, Beckmann, M., additional, Blohmer, J.-U., additional, Costa, S.-D., additional, Decker, T., additional, Diel, I., additional, Fasching, P., additional, Fehm, T., additional, Janni, W., additional, Lück, H.-J., additional, Maass, N., additional, Scharl, A., additional, and Loibl, S., additional

Published
2015
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214. International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fifth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2013)

Author

Amoroso, V., primary, Generali, D., additional, Buchholz, T., additional, Cristofanilli, M., additional, Pedersini, R., additional, Curigliano, G., additional, Daidone, M. G., additional, Di Cosimo, S., additional, Dowsett, M., additional, Fox, S., additional, Harris, A. L., additional, Makris, A., additional, Vassalli, L., additional, Ravelli, A., additional, Cappelletti, M. R., additional, Hatzis, C., additional, Hudis, C. A., additional, Pedrazzoli, P., additional, Sapino, A., additional, Semiglazov, V., additional, Von Minckwitz, G., additional, Simoncini, E. L., additional, Jacobs, M. A., additional, Barry, P., additional, Kuhn, T., additional, Darby, S., additional, Hermelink, K., additional, Symmans, F., additional, Gennari, A., additional, Schiavon, G., additional, Dogliotti, L., additional, Berruti, A., additional, and Bottini, A., additional

Published
2015
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222. [Preoperative chemotherapy in breast cancer and the development of new predictive markers]

Author

Carsten Denkert, Schickling O, and von Minckwitz G

Subjects
Chemotherapy, Adjuvant, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Breast Neoplasms, Female, Combined Modality Therapy
Abstract

Neoadjuvant chemotherapy provides today a valid option for many patients with primary breast cancer. For evaluation of treatment response as well as for biomarker studies for prediction of response, an efficient collaboration between pathologists and gynaecological oncologists is essential. This report reflects aims and indication according to the current opinion, describes advantages and disadvantages in comparison to the conventional adjuvant approach and provides guidelines on how to conduct the whole treatment concept of neoadjuvant therapy. Current and projected study concepts of preoperative and following postsurgical treatments in Germany are introduced. While the basic principles of histopathological evaluation of tumour specimens from neo-adjuvant breast cancer studies are similar to conventional surgical therapy, some aspects of histopathological management are of special importance in these studies.

Published
2007

226. The AURORA initiative for metastatic breast cancer

Author

Zardavas, D, primary, Maetens, M, additional, Irrthum, A, additional, Goulioti, T, additional, Engelen, K, additional, Fumagalli, D, additional, Salgado, R, additional, Aftimos, P, additional, Saini, K S, additional, Sotiriou, C, additional, Campbell, P, additional, Dinh, P, additional, von Minckwitz, G, additional, Gelber, R D, additional, Dowsett, M, additional, Di Leo, A, additional, Cameron, D, additional, Baselga, J, additional, Gnant, M, additional, Goldhirsch, A, additional, Norton, L, additional, and Piccart, M, additional

Published
2014
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227. Efficacy and Safety in Tania, a Randomised Phase III Trial of Continued or Reintroduced Bevacizumab (Bev) After 1St-Line Bev for Her2-Negative Locally Recurrent/Metastatic Breast Cancer (Lr/Mbc)

Author

von Minckwitz, G., primary, Puglisi, F., additional, Cortes, J., additional, Vrdoljak, E., additional, Marschner, N., additional, Zielinski, C., additional, Villanueva, C.B., additional, Romieu, G., additional, Láng, I., additional, Ciruelos, E., additional, De Laurentiis, M., additional, Veyret, C., additional, De Ducla, S., additional, Freudensprung, U., additional, Srock, S., additional, and Gligorov, J., additional

Published
2014
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228. Dual Blockade with Afatinib and Trastuzumab As Neoadjuvant Treatment for Patients with Locally Advanced or Operable Breast Cancer Receiving Taxane-Anthracycline Containing Chemotherapy (Dafne)-Gbg70 – Efficacy and Safety Analysis

Author

Hanusch, C., primary, Schneeweiss, A., additional, Untch, M., additional, Paepke, S., additional, Kümmel, S., additional, Jackisch, C., additional, Huober, J., additional, Hilfrich, J., additional, Gerber, B., additional, Eidtmann, H., additional, Denkert, C., additional, Costa, S., additional, Blohmer, J.U., additional, Loibl, S., additional, Burchardi, N., additional, and von Minckwitz, G., additional

Published
2014
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229. Intense Dose-Dense Epirubicin (E), Paclitaxel (T), Cyclophosphamide (C) (Iddetc) is Highly Effective in Adjuvant Therapy of Node-Positive Breast Cancer Patients (Pts). an Analysis of the Gbg, Ago-B, and Noggo Study Groups

Author

Thomssen, C., primary, von Minckwitz, G., additional, Jackisch, C., additional, Lueck, H.J., additional, Schneeweiss, A., additional, Tesch, H., additional, Elling, D., additional, Harbeck, N., additional, Conrad, B., additional, Fehm, T., additional, Huober, J., additional, Müller, V., additional, Bauerfeind, I., additional, Loibl, S., additional, Nekljudova, V., additional, Untch, M., additional, and Moebus, V., additional

Published
2014
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230. Gain2: Adjuvant Phase III Trial Comparing an Intensified Dose-Dense Adjuvant Therapy with Enpc Compared with a Dose-Dense, Dose-Adapted Therapy with Dtec Dtdocetaxel in Patients with Primary Breast Cancer and a High Risk of Recurrence

Author

Noeding, S., primary, Forstbauer, H., additional, Wachsmann, G., additional, Ober, A., additional, Schneeweiss, A., additional, Christensen, B., additional, von Abel, E., additional, Grischke, E., additional, Höffkes, H., additional, Klare, P., additional, Ko, Y., additional, Schmatloch, S., additional, Burchardi, N., additional, Loibl, S., additional, von Minckwitz, G., additional, and Möbus, V., additional

Published
2014
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231. 2. Internationale Konsensuskonferenz zum fortgeschrittenen Mammakarzinom (ABC2), Lissabon, 09.11.2013 – ABC2-Konsensus: Bewertung durch eine deutsche Expertengruppe

Author

Harbeck, N., additional, Marschner, N., additional, Untch, M., additional, Decker, T., additional, Hegewisch-Becker, S., additional, Jackisch, C., additional, Huober, J., additional, Lück, H., additional, von Minckwitz, G., additional, Scharl, A., additional, Schneeweiss, A., additional, Tesch, H., additional, Welt, A., additional, Würstlein, R., additional, and Thomssen, C., additional

Published
2014
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233. 273P - A randomized phase II study to determine the efficacy and tolerability of two doses of eribulin plus lapatinib in trastuzumab pre-treated patients with Her2-positive metastatic breast cancer - E-Vita -

Author

Bischoff, J., Barinoff, J., Mundhenke, C., Bauerschlag, D., Costa, S.D., Herr, D., Lübe, K., Marmé, F., Maass, N., von Minckwitz, G., Grischke, E.-M., Müller, V., Schmidt, M., Gerber, B., Kümmel, S., Schumacher, C., Krabisch, P., Thill, M., Nekljudova, V., and Loibl, S.

Published
2016
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235. Abstract OT2-6-11: PENELOPE: Phase III study evaluating palbociclib (PD-0332991), a cyclin-dependent kinase (CDK) 4/6 inhibitor in patients with hormone-receptor-positive, HER2-normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy (GBG-78/BIG1-13)

Author

von Minckwitz, G, primary, Bear, H, additional, Bonnefoi, H, additional, Colleoni, M, additional, Gelmon, K, additional, Gnant, M, additional, Kim, S-B, additional, Loibl, S, additional, Makris, A, additional, Martin, M, additional, Nekljudova, V, additional, Rugo, H, additional, Saini, KS, additional, Toi, M, additional, Untch, M, additional, and Werutsky, G, additional

Published
2013
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236. Abstract S5-05: Postneoadjuvant treatment with zoledronate in patients with tumor residuals after anthracyclines-taxane-based chemotherapy for primary breast cancer – The phase III NATAN study (GBG 36/ABCSG XX)

Author

von Minckwitz, G, primary, Rezai, M, additional, Eidtmann, H, additional, Tesch, H, additional, Huober, J, additional, Gerber, B, additional, Zahn, DM, additional, Costa, S, additional, Gnant, M, additional, Blohmer, JU, additional, Denkert, C, additional, Hanusch, C, additional, Jackisch, C, additional, Kümmel, S, additional, Fasching, PA, additional, Schneeweiss, A, additional, Paepke, S, additional, Untch, M, additional, Nekljudova, V, additional, Mehta, K, additional, and Loibl, S, additional

Published
2013
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237. Abstract P5-17-01: A definition of a high-risk early-breast cancer population based on data from the collaborative trials in neoadjuvant breast cancer (CTNeoBC) meta-analysis

Author

Cortazar, P, primary, Zhang, L, additional, Untch, M, additional, Mehta, K, additional, Constantino, J, additional, Wolmark, N, additional, Bonnefoi, H, additional, Piccart, M, additional, Gianni, L, additional, Valagussa, P, additional, Zujewski, JA, additional, Justice, R, additional, Loibl, S, additional, Swain, SM, additional, Bogaerts, J, additional, Baselga, J, additional, Prowell, TM, additional, Rastogi, P, additional, Sridhara, R, additional, Tang, S, additional, Pazdur, R, additional, Mamounas, E, additional, and von Minckwitz, G, additional

Published
2013
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240. Abstract S1-06: Increased tumor-associated lymphocytes predict benefit from addition of carboplatin to neoadjuvant therapy for triple-negative and HER2-positive early breast cancer in the GeparSixto trial (GBG 66)

Author

Denkert, C, primary, Loibl, S, additional, Salat, C, additional, Sinn, BV, additional, Schem, C, additional, Endris, V, additional, Klare, P, additional, Schmitt, WD, additional, Blohmer, J-U, additional, Weichert, W, additional, Tesch, H, additional, Darb-Esfahani, S, additional, Kümmel, S, additional, Sinn, P, additional, Stenzinger, A, additional, Jackisch, C, additional, Dietel, M, additional, Reimer, T, additional, Loi, S, additional, Mehta, K, additional, Gade, S, additional, Untch, M, additional, and von Minckwitz, G, additional

Published
2013
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242. Abstract OT1-1-06: A phase 3, randomized, open-label trial comparing trastuzumab emtansine and trastuzumab as adjuvant therapy for HER2-positive primary breast cancer with residual invasive tumor in the breast or axillary lymph nodes following preoperative therapy (KATHERINE)

Author

Geyer, CE, primary, Loibl, S, additional, Mamounas, EP, additional, Untch, M, additional, Wolmark, N, additional, Huang, C-S, additional, Mano, M, additional, Zheng, M, additional, Smitt, M, additional, and von Minckwitz, G, additional

Published
2013
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243. Abstract S4-06: PIK3CA mutation predicts resistance to anti-HER2/chemotherapy in primary HER2-positive/hormone-receptor-positive breast cancer – Prospective analysis of 737 participants of the GeparSixto and GeparQuinto studies

Author

Loibl, S, primary, Denkert, C, additional, Schneeweis, A, additional, Paepke, S, additional, Lehmann, A, additional, Rezai, M, additional, Zahm, D-M, additional, Sinn, P, additional, Khandan, F, additional, Eidtmann, H, additional, Dohnal, K, additional, Huober, J, additional, Loi, S, additional, Pfitzner, B, additional, Fasching, PA, additional, Andre, F, additional, Lindner, J, additional, Sotiriou, C, additional, Guo, S, additional, Gade, S, additional, Nekljudova, V, additional, Untch, M, additional, and von Minckwitz, G, additional

Published
2013
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244. Abstract P3-14-04: The choice of the indicator lesion impacts on the pCR rate – An analysis of 114 bilateral breast cancer patients treated within neoadjuvant trials

Author

Loibl, S, primary, Mergler, B, additional, Eppel, A, additional, Solbach, C, additional, Lübbe, KM, additional, Eidtmann, H, additional, Rezai, M, additional, Hanusch, C, additional, Fehm, T, additional, Bartzke, G, additional, Burgmann, D-M, additional, Krabisch, P, additional, Untch, M, additional, Nekljudova, V, additional, and von Minckwitz, G, additional

Published
2013
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246. Abstract PD2-2: Body mass index (BMI) and treatment outcome of breast cancer patients receiving neoadjuvant therapy (NACT)

Author

Fontanella, C, primary, von Minckwitz, G, additional, Mergler, B, additional, Neven, P, additional, Blohmer, JU, additional, Costa, SD, additional, Denkert, C, additional, Eidtmann, H, additional, Gerber, B, additional, Vanoppen, M, additional, Hanusch, C, additional, Hilfrich, J, additional, Huober, J, additional, Schneeweiss, A, additional, Paepke, S, additional, Jackisch, C, additional, Keyur, M, additional, Nekljudova, V, additional, Untch, M, additional, and Loibl, S, additional

Published
2013
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247. Abstract S4-07: Effects of bisphosphonate treatment on recurrence and cause-specific mortality in women with early breast cancer: A meta-analysis of individual patient data from randomised trials

Author

Coleman, R, primary, Gnant, M, additional, Paterson, A, additional, Powles, T, additional, von Minckwitz, G, additional, Pritchard, K, additional, Bergh, J, additional, Bliss, J, additional, Gralow, J, additional, Anderson, S, additional, Evans, V, additional, Pan, H, additional, Bradley, R, additional, Davies, C, additional, and Gray, R, additional

Published
2013
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248. Abstract OT2-6-08: Phase II, randomized, parallel-cohort study of neoadjuvant buparlisib (BKM120) in combination with trastuzumab and paclitaxel in women with HER2-positive, PIK3CA mutant and PIK3CA wild-type primary breast cancer – NeoPHOEBE

Author

Loi, S, primary, Loibl, S, additional, Di Cosimo, S, additional, Nekljudova, V, additional, Flamen, P, additional, Saini, KS, additional, Michiels, S, additional, de la Pena, L, additional, Nanni, S, additional, Urban, P, additional, Piccart, M, additional, von Minckwitz, G, additional, and Baselga, J, additional

Published
2013
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249. Ki67 levels as predictive and prognostic parameters in pretherapeutic breast cancer core biopsies: a translational investigation in the neoadjuvant GeparTrio trial

Author

Denkert, C., primary, Loibl, S., additional, Müller, B.M., additional, Eidtmann, H., additional, Schmitt, W.D., additional, Eiermann, W., additional, Gerber, B., additional, Tesch, H., additional, Hilfrich, J., additional, Huober, J., additional, Fehm, T., additional, Barinoff, J., additional, Jackisch, C., additional, Prinzler, J., additional, Rüdiger, T., additional, Erbstößer, E., additional, Blohmer, J.U., additional, Budczies, J., additional, Mehta, K.M., additional, and von Minckwitz, G., additional

Published
2013
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250. Trastuzumab Improves the Efficacy of Chemotherapy in Breast Cancer Treatment beyond Progression

Author

Uhlig M, Pirvulescu C, and von Minckwitz G

Subjects
Oncology, medicine.medical_specialty, Chemotherapy, Reports · Mitteilungen, business.industry, medicine.medical_treatment, medicine.disease, Metastatic breast cancer, Capecitabine, Breast cancer, Trastuzumab, Internal medicine, medicine, Surgery, skin and connective tissue diseases, business, neoplasms, medicine.drug
Abstract

The GBG 26 — TBP study of the German Breast Group addressed the question of whether the treatment of women with HER2-positive metastatic breast cancer with trastuzumab is effective beyond progression (Trastuzumab Beyond Progression TBP). In this study, women with metastatic HER2-positive breast cancer who had progressed on prior trastuzumab treatment were treated either with a combination of trastuzumab (Herceptin(r), Roche Pharma AG, Grenzach-Whylen, Germany) and capecitabine (Xeloda(r), Roche Pharma AG) or capecitabine alone.

Published
2008

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