251. Neuroprotection after a first episode of mania: a randomized controlled maintenance trial comparing the effects of lithium and quetiapine on grey and white matter volume
- Author
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Benny Liberg, Michael Berk, Sue M. Cotton, Murat Yücel, Christos Pantelis, Kelly Allott, Paul Klauser, Lisa Henry, Alex Fornito, Patrick D. McGorry, Orwa Dandash, Craig Macneil, Chao Suo, Rothanthi Daglas, and Melissa K. Hasty
- Subjects
Male ,medicine.medical_specialty ,Bipolar Disorder ,Internal capsule ,Lithium (medication) ,Grey matter ,Neuroprotection ,Maintenance Chemotherapy ,White matter ,Quetiapine Fumarate ,Young Adult ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Antimanic Agents ,medicine ,Humans ,Single-Blind Method ,Gray Matter ,Psychiatry ,Biological Psychiatry ,First episode ,business.industry ,Organ Size ,White Matter ,030227 psychiatry ,3. Good health ,Psychiatry and Mental health ,Neuroprotective Agents ,medicine.anatomical_structure ,Anesthesia ,Lithium Compounds ,Quetiapine ,Female ,Original Article ,medicine.symptom ,Corrigendum ,Psychology ,business ,Mania ,030217 neurology & neurosurgery ,Antipsychotic Agents ,medicine.drug - Abstract
Lithium and quetiapine are effective treatments for bipolar disorder, but their potential neuroprotective effects in humans remain unclear. A single blinded equivalence randomized controlled maintenance trial was conducted in a prospective cohort of first-episode mania (FEM) patients (n=26) to longitudinally compare the putative protective effects of lithium and quetapine on grey and white matter volume. A healthy control sample was also collected (n=20). Using structural MRI scans, voxel-wise grey and white matter volumes at baseline and changes over time in response to treatment were investigated. Patients were assessed at three time points (baseline, 3 and 12-month follow-up), whereas healthy controls were assessed at two time points (baseline and 12-month follow-up). Patients were randomized to lithium (serum level 0.6 mmol l−1, n=20) or quetiapine (flexibly dosed up to 800 mg per day, n=19) monotherapy. At baseline, compared with healthy control subjects, patients with FEM showed reduced grey matter in the orbitofrontal cortex, anterior cingulate, inferior frontal gyrus and cerebellum. In addition, patients had reduced internal capsule white matter volume bilaterally (t1,66>3.20, P2,112=8.54, PPost hoc testing showed that, compared with baseline, lithium was more effective than quetiapine in slowing the progression of white matter volume reduction after 12 months (t1,24=3.76, P
- Published
- 2017